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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-493-5p ABR 0.85 0.00529 -0.82 1.0E-5 miRNATAP -0.13 1.0E-5 NA
2 hsa-miR-493-5p ACVR2A 0.85 0.00529 -0.44 0.02646 miRNATAP -0.12 0.00011 NA
3 hsa-miR-140-5p ADAM10 0.84 4.0E-5 0.67 0.00766 MirTarget; PITA; miRanda -0.12 0.04176 NA
4 hsa-miR-155-5p ADAM10 1.2 0.00086 0.67 0.00766 miRNAWalker2 validate -0.11 0.00135 NA
5 hsa-miR-199a-3p ADAM10 0.64 0.03803 0.67 0.00766 MirTarget -0.1 0.01088 NA
6 hsa-miR-199b-3p ADAM10 0.64 0.03717 0.67 0.00766 MirTarget -0.1 0.01105 NA
7 hsa-miR-374b-5p ADAM10 0.07 0.72267 0.67 0.00766 MirTarget; mirMAP -0.2 0.00316 NA
8 hsa-miR-655-3p ADAM10 0.49 0.13701 0.67 0.00766 MirTarget -0.12 0.0015 27259866 MicroRNA 655 3p functions as a tumor suppressor by regulating ADAM10 and β catenin pathway in Hepatocellular Carcinoma; MiR-655-3p might functions as a tumor suppressor by directly targeting ADAM10 and indirectly regulating β-catenin pathway in the development of progression of HCC
9 hsa-miR-92b-3p ADAM10 1.2 0 0.67 0.00766 MirTarget -0.11 0.0222 NA
10 hsa-miR-493-5p ADCY6 0.85 0.00529 -0.13 0.52489 miRNATAP -0.12 0.0003 NA
11 hsa-miR-493-5p AKAP1 0.85 0.00529 -0.34 0.0302 miRNATAP -0.11 1.0E-5 NA
12 hsa-miR-493-5p ANKRD50 0.85 0.00529 -0.88 0.00174 miRNATAP -0.17 0.00014 NA
13 hsa-miR-493-5p AR 0.85 0.00529 -3.3 0 miRNATAP -0.31 0.00377 NA
14 hsa-miR-493-5p ARID1B 0.85 0.00529 -0.47 0.00056 MirTarget -0.1 0 NA
15 hsa-miR-493-5p ATP1B1 0.85 0.00529 -0.24 0.50233 miRNATAP -0.14 0.01309 NA
16 hsa-miR-493-5p BBX 0.85 0.00529 -0.51 0.00131 MirTarget; mirMAP; miRNATAP -0.11 1.0E-5 NA
17 hsa-miR-493-5p BCOR 0.85 0.00529 -0.51 0.01107 MirTarget; miRNATAP -0.14 1.0E-5 NA
18 hsa-miR-493-5p BHLHE41 0.85 0.00529 -0.07 0.8646 MirTarget; miRNATAP -0.24 0.0002 NA
19 hsa-miR-493-5p BTAF1 0.85 0.00529 -0.16 0.37827 MirTarget; miRNATAP -0.12 7.0E-5 NA
20 hsa-miR-493-5p CAMK2N1 0.85 0.00529 0.6 0.15571 MirTarget; miRNATAP -0.18 0.00899 NA
21 hsa-miR-493-5p CCNT2 0.85 0.00529 0.05 0.80346 miRNATAP -0.12 0.00026 NA
22 hsa-miR-493-5p CITED2 0.85 0.00529 -0.85 0.00024 miRNATAP -0.15 3.0E-5 NA
23 hsa-miR-493-5p COBLL1 0.85 0.00529 -0.74 0.01674 miRNATAP -0.16 0.00122 NA
24 hsa-miR-493-5p CPEB2 0.85 0.00529 -1.81 0 miRNATAP -0.1 0.00995 NA
25 hsa-miR-493-5p CTDSPL 0.85 0.00529 -0.64 0.00013 MirTarget; miRNATAP -0.11 2.0E-5 NA
26 hsa-miR-493-5p CTNND2 0.85 0.00529 -1.47 0.02616 MirTarget -0.24 0.02279 NA
27 hsa-miR-493-5p DAB2IP 0.85 0.00529 -0.66 0.00125 MirTarget; miRNATAP -0.15 0 NA
28 hsa-miR-493-5p DENND4C 0.85 0.00529 -0.64 0.00049 MirTarget -0.11 0.00032 NA
29 hsa-miR-493-5p ESRRG 0.85 0.00529 -2.26 0.0002 miRNATAP -0.32 0.001 NA
30 hsa-miR-493-5p FLNB 0.85 0.00529 0.26 0.22575 mirMAP -0.12 0.00032 NA
31 hsa-miR-493-5p FLRT1 0.85 0.00529 -0.96 0.00237 miRNATAP -0.15 0.00399 NA
32 hsa-miR-493-5p GATA2 0.85 0.00529 -0.15 0.72083 MirTarget; miRNATAP -0.26 8.0E-5 NA
33 hsa-miR-493-5p HAPLN1 0.85 0.00529 1.71 0.00405 mirMAP -0.25 0.00975 NA
34 hsa-miR-493-5p IRF2 0.85 0.00529 -0.05 0.72117 miRNATAP -0.12 0 NA
35 hsa-miR-493-5p KLHL24 0.85 0.00529 0.03 0.87663 MirTarget -0.1 0.0008 NA
36 hsa-miR-493-5p LIMCH1 0.85 0.00529 -1.22 0.00258 MirTarget; miRNATAP -0.27 3.0E-5 NA
37 hsa-miR-493-5p LRP1B 0.85 0.00529 -0.99 0.12166 miRNATAP -0.34 0.00105 NA
38 hsa-miR-493-5p MBD5 0.85 0.00529 -1.15 0 mirMAP -0.15 0 NA
39 hsa-miR-493-5p MBNL3 0.85 0.00529 -1.4 8.0E-5 MirTarget; mirMAP; miRNATAP -0.17 0.00235 NA
40 hsa-miR-493-5p MECOM 0.85 0.00529 -0.11 0.77709 miRNATAP -0.2 0.00131 NA
41 hsa-miR-493-5p NFIA 0.85 0.00529 -2.1 0 miRNATAP -0.15 0.00041 NA
42 hsa-miR-493-5p NR2C2 0.85 0.00529 -0.08 0.70827 MirTarget -0.12 0.00059 NA
43 hsa-miR-493-5p NUDT4 0.85 0.00529 -0.29 0.20205 MirTarget; miRNATAP -0.11 0.00268 NA
44 hsa-miR-493-5p OCRL 0.85 0.00529 -0.47 0.00073 MirTarget -0.11 0 NA
45 hsa-miR-493-5p PDE4D 0.85 0.00529 -2.17 0 miRNATAP -0.12 0.00536 NA
46 hsa-miR-493-5p PHC3 0.85 0.00529 -0.45 0.00181 MirTarget -0.1 1.0E-5 NA
47 hsa-miR-493-5p PIK3R1 0.85 0.00529 -1.16 0 MirTarget; miRNATAP -0.14 0.00029 NA
48 hsa-miR-493-5p PLEKHA5 0.85 0.00529 -0.52 0.00633 MirTarget -0.12 9.0E-5 NA
49 hsa-miR-493-5p RAB11FIP2 0.85 0.00529 -0.86 1.0E-5 MirTarget -0.1 0.00098 NA
50 hsa-miR-493-5p RAI1 0.85 0.00529 -0.03 0.88192 miRNATAP -0.14 0 NA
51 hsa-miR-493-5p RALGPS1 0.85 0.00529 -0.48 0.13317 MirTarget; miRNATAP -0.11 0.02731 NA
52 hsa-miR-493-5p RPS6KA5 0.85 0.00529 -1.71 0 MirTarget -0.22 0 NA
53 hsa-miR-493-5p SEMA3E 0.85 0.00529 -3.86 0 MirTarget -0.22 0.02918 NA
54 hsa-miR-493-5p SLC25A12 0.85 0.00529 -0.95 0 MirTarget -0.11 9.0E-5 NA
55 hsa-miR-493-5p SLFN5 0.85 0.00529 -0.76 0.00885 mirMAP -0.14 0.0032 NA
56 hsa-miR-493-5p SLITRK6 0.85 0.00529 -0.74 0.30223 MirTarget -0.37 0.00126 NA
57 hsa-miR-493-5p SNX1 0.85 0.00529 -0.53 0 mirMAP -0.12 0 NA
58 hsa-miR-493-5p SOS2 0.85 0.00529 -0.54 3.0E-5 miRNATAP -0.11 0 NA
59 hsa-miR-493-5p SVIL 0.85 0.00529 -2.04 0 miRNATAP -0.1 0.03039 NA
60 hsa-miR-493-5p TRIM2 0.85 0.00529 -1.25 0.00011 mirMAP -0.17 0.0008 NA
61 hsa-miR-493-5p USP12 0.85 0.00529 -1.45 0 miRNATAP -0.1 0.02019 NA
62 hsa-miR-493-5p ZDHHC21 0.85 0.00529 -0.41 0.07107 MirTarget -0.11 0.00164 NA
63 hsa-miR-493-5p ZMIZ1 0.85 0.00529 -0.41 0.03473 MirTarget; miRNATAP -0.12 0.00016 NA
64 hsa-miR-493-5p ZNF33A 0.85 0.00529 0.02 0.91924 mirMAP -0.11 0 NA
65 hsa-miR-493-5p ZNF780B 0.85 0.00529 -0.23 0.21612 mirMAP -0.14 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1004 9.439e-07 0.004392
NumGOOverlapSizeP ValueAdj. P Value
1 MACROMOLECULAR COMPLEX BINDING 15 1399 9.266e-06 0.008608
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cAMP_signaling_pathway_hsa04024 4 198 0.002773 0.1018
2 TNF_signaling_pathway_hsa04668 3 108 0.003997 0.1018
3 Oocyte_meiosis_hsa04114 3 124 0.005873 0.1018
4 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.009193 0.1163
5 MAPK_signaling_pathway_hsa04010 4 295 0.01118 0.1163
6 Focal_adhesion_hsa04510 3 199 0.02098 0.181
7 ErbB_signaling_pathway_hsa04012 2 85 0.02612 0.181
8 Gap_junction_hsa04540 2 88 0.02785 0.181
9 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.03457 0.1998
10 FoxO_signaling_pathway_hsa04068 2 132 0.05796 0.275
11 Apoptosis_hsa04210 2 138 0.06267 0.275
12 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.06346 0.275
13 mTOR_signaling_pathway_hsa04150 2 151 0.0733 0.2898
14 Jak_STAT_signaling_pathway_hsa04630 2 162 0.08271 0.2898
15 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.08359 0.2898
16 Rap1_signaling_pathway_hsa04015 2 206 0.1236 0.384
17 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.1255 0.384
18 Ras_signaling_pathway_hsa04014 2 232 0.1496 0.4211
19 Endocytosis_hsa04144 2 244 0.162 0.4211
20 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.2785 0.6026

Quest ID: b7ca1af12f4c1351702aa5a35b191fdd