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show label of nodes with degree >=

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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-34c-3p CLCA4 0.24 0.31147 0.31 0.70539 miRNATAP -0.65 0.00744 NA
2 hsa-miR-186-5p CXCL13 -0.1 0.92207 0.06 0.90943 miRNATAP -0.74 0.00287 NA
3 hsa-miR-26b-5p CXCL13 0 0.99905 0.06 0.90943 miRNAWalker2 validate -0.71 0.00243 NA
4 hsa-miR-429 CXCL13 -0.24 0.83536 0.06 0.90943 miRanda -0.69 0 NA
5 hsa-miR-491-5p CXCL13 -0.3 0.18904 0.06 0.90943 miRanda -0.55 0.00041 NA
6 hsa-let-7d-5p DSC3 -0.04 0.96726 0.17 0.81099 miRNAWalker2 validate -1 0.00437 NA
7 hsa-miR-10a-3p DSC3 -0.04 0.92309 0.17 0.81099 mirMAP -0.44 0.01139 NA
8 hsa-miR-186-5p DSC3 -0.1 0.92207 0.17 0.81099 mirMAP -0.98 0.00125 NA
9 hsa-miR-320a DSC3 -0.11 0.93187 0.17 0.81099 miRanda -0.61 0.01729 NA
10 hsa-miR-320b DSC3 -0.03 0.97282 0.17 0.81099 miRanda -0.59 0.0108 NA
11 hsa-miR-338-3p DSC3 0.26 0.82352 0.17 0.81099 miRanda -0.49 0.00218 NA
12 hsa-miR-338-5p DSC3 0.25 0.53407 0.17 0.81099 miRNATAP -0.5 0.00132 NA
13 hsa-miR-33a-3p DSC3 -0.48 0.04738 0.17 0.81099 mirMAP -0.56 0.00222 NA
14 hsa-miR-33a-5p DSC3 -0.13 0.85242 0.17 0.81099 miRNAWalker2 validate -0.26 0.02388 NA
15 hsa-miR-374b-3p DSC3 -0.08 0.72231 0.17 0.81099 mirMAP -0.58 0.015 NA
16 hsa-miR-576-5p DSC3 -0.06 0.88424 0.17 0.81099 mirMAP -0.67 0.00205 NA
17 hsa-miR-577 DSC3 -0.71 0.30987 0.17 0.81099 mirMAP -0.43 0.0001 NA
18 hsa-miR-584-5p DSC3 -0.16 0.88888 0.17 0.81099 mirMAP -0.36 0.01358 NA
19 hsa-miR-590-3p DSC3 0.08 0.81071 0.17 0.81099 miRanda; miRNATAP -0.46 0.01156 NA
20 hsa-miR-7-1-3p DSC3 -0.13 0.84642 0.17 0.81099 mirMAP -0.68 0.00116 NA
21 hsa-let-7f-1-3p LPAR1 -0.11 0.81783 0.26 0.54395 mirMAP -0.54 4.0E-5 NA
22 hsa-miR-16-2-3p LPAR1 0.02 0.95282 0.26 0.54395 MirTarget; mirMAP -0.26 0.00131 NA
23 hsa-miR-188-5p LPAR1 -0.02 0.94896 0.26 0.54395 MirTarget -0.31 0 NA
24 hsa-miR-200b-3p LPAR1 -0.18 0.90839 0.26 0.54395 MirTarget; TargetScan -0.39 0 NA
25 hsa-miR-200c-3p LPAR1 -0.17 0.92932 0.26 0.54395 miRNAWalker2 validate; MirTarget; miRNATAP -0.41 0 NA
26 hsa-miR-20a-3p LPAR1 0 0.99335 0.26 0.54395 MirTarget -0.26 2.0E-5 NA
27 hsa-miR-221-5p LPAR1 0.27 0.49183 0.26 0.54395 MirTarget; miRNATAP -0.16 0.01095 NA
28 hsa-miR-23a-3p LPAR1 -0.02 0.99063 0.26 0.54395 MirTarget; miRNATAP -0.53 0.00103 NA
29 hsa-miR-26b-5p LPAR1 0 0.99905 0.26 0.54395 miRNATAP -0.36 0.00227 NA
30 hsa-miR-32-3p LPAR1 0.17 0.57537 0.26 0.54395 mirMAP -0.26 3.0E-5 NA
31 hsa-miR-324-5p LPAR1 -0.09 0.86082 0.26 0.54395 miRanda -0.44 0 NA
32 hsa-miR-335-3p LPAR1 -0.17 0.87115 0.26 0.54395 mirMAP -0.37 0 NA
33 hsa-miR-339-5p LPAR1 -0.01 0.98813 0.26 0.54395 miRanda -0.35 0 NA
34 hsa-miR-361-5p LPAR1 -0.16 0.88875 0.26 0.54395 miRanda -0.44 0.00266 NA
35 hsa-miR-374a-5p LPAR1 -0.23 0.75404 0.26 0.54395 MirTarget -0.26 0.03587 NA
36 hsa-miR-374b-5p LPAR1 -0.27 0.75538 0.26 0.54395 MirTarget -0.46 0.00011 NA
37 hsa-miR-421 LPAR1 -0.23 0.52658 0.26 0.54395 miRanda -0.37 1.0E-5 NA
38 hsa-miR-429 LPAR1 -0.24 0.83536 0.26 0.54395 MirTarget; miRanda; miRNATAP -0.35 0 NA
39 hsa-miR-452-5p LPAR1 -0.04 0.96894 0.26 0.54395 MirTarget -0.28 0.00088 NA
40 hsa-miR-501-5p LPAR1 -0.1 0.73625 0.26 0.54395 MirTarget; miRNATAP -0.25 7.0E-5 NA
41 hsa-miR-576-5p LPAR1 -0.06 0.88424 0.26 0.54395 mirMAP -0.33 0.00012 NA
42 hsa-miR-671-5p LPAR1 0.01 0.95984 0.26 0.54395 MirTarget -0.34 0.00015 NA
43 hsa-miR-7-1-3p LPAR1 -0.13 0.84642 0.26 0.54395 MirTarget -0.28 0.00091 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

hsa-let-7f-1-3p;hsa-miR-16-2-3p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-221-5p;hsa-miR-26b-5p;hsa-miR-32-3p;hsa-miR-324-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-452-5p;hsa-miR-576-5p;hsa-miR-671-5p;hsa-miR-7-1-3p 18 LPAR1 Sponge network 0.3 0.65988 0.256 0.54395 0.347
2 MIAT hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-221-5p;hsa-miR-26b-5p;hsa-miR-339-5p;hsa-miR-421;hsa-miR-452-5p;hsa-miR-671-5p 10 LPAR1 Sponge network 0.29 0.50324 0.256 0.54395 0.316
3 CECR7 hsa-let-7f-1-3p;hsa-miR-16-2-3p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-221-5p;hsa-miR-23a-3p;hsa-miR-26b-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-361-5p;hsa-miR-429;hsa-miR-452-5p;hsa-miR-671-5p;hsa-miR-7-1-3p 16 LPAR1 Sponge network -0.206 0.73331 0.256 0.54395 0.297

Quest ID: b8020d00c1202bd9ed304dee5be872f5