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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-32-5p ABI3BP 0 0 0 0 miRNATAP -0.45 0 NA
2 hsa-miR-32-5p ABLIM1 0 0 0 0 mirMAP -0.22 0 NA
3 hsa-miR-32-5p ACACB 0 0 0 0 mirMAP -0.59 0 NA
4 hsa-miR-32-5p ACTC1 0 0 0 0 MirTarget -0.22 0.00254 NA
5 hsa-miR-32-5p ADAM10 0 0 0 0 MirTarget -0.15 0 NA
6 hsa-miR-32-5p ADAM22 0 0 0 0 mirMAP -0.33 0 NA
7 hsa-miR-32-5p ADAM23 0 0 0 0 miRNATAP -0.25 1.0E-5 NA
8 hsa-miR-32-5p ADAMTSL1 0 0 0 0 miRNATAP -0.28 0 NA
9 hsa-miR-32-5p ADAMTSL3 0 0 0 0 MirTarget; miRNATAP -0.26 0 NA
10 hsa-miR-32-5p ADCY1 0 0 0 0 mirMAP -0.29 5.0E-5 NA
11 hsa-miR-32-5p ADCY5 0 0 0 0 mirMAP -0.58 0 NA
12 hsa-miR-32-5p ADCY9 0 0 0 0 mirMAP -0.13 1.0E-5 NA
13 hsa-miR-32-5p ADCYAP1R1 0 0 0 0 mirMAP -0.77 0 NA
14 hsa-miR-32-5p ADM 0 0 0 0 miRNATAP -0.22 7.0E-5 NA
15 hsa-miR-32-5p AFF2 0 0 0 0 mirMAP -0.27 0 NA
16 hsa-miR-32-5p AFF3 0 0 0 0 MirTarget -0.41 0 NA
17 hsa-miR-32-5p AFF4 0 0 0 0 mirMAP; miRNATAP -0.16 0 NA
18 hsa-miR-32-5p AKAP10 0 0 0 0 miRNATAP -0.15 0 NA
19 hsa-miR-32-5p AKAP12 0 0 0 0 mirMAP -0.63 0 NA
20 hsa-miR-32-5p ALDH1L2 0 0 0 0 mirMAP -0.1 0.01731 NA
21 hsa-miR-32-5p ALPK3 0 0 0 0 miRNATAP -0.24 0 NA
22 hsa-miR-32-5p ANGPTL2 0 0 0 0 miRNATAP -0.43 0 NA
23 hsa-miR-32-5p ANKRD12 0 0 0 0 MirTarget -0.1 6.0E-5 NA
24 hsa-miR-32-5p APCDD1L 0 0 0 0 mirMAP -0.35 0 NA
25 hsa-miR-32-5p ARHGAP24 0 0 0 0 MirTarget -0.23 0 NA
26 hsa-miR-32-5p ARHGAP29 0 0 0 0 MirTarget -0.27 0 NA
27 hsa-miR-32-5p ARHGEF17 0 0 0 0 miRNATAP -0.19 0 NA
28 hsa-miR-32-5p ARL10 0 0 0 0 mirMAP -0.24 0 NA
29 hsa-miR-32-5p ARRDC3 0 0 0 0 MirTarget; miRNATAP -0.21 0 NA
30 hsa-miR-32-5p ARRDC4 0 0 0 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.22 0 NA
31 hsa-miR-32-5p ASB1 0 0 0 0 mirMAP -0.15 0 NA
32 hsa-miR-32-5p ATP2B4 0 0 0 0 MirTarget -0.19 0 NA
33 hsa-miR-32-5p ATP7A 0 0 0 0 miRNATAP -0.14 0 NA
34 hsa-miR-32-5p ATP8A2 0 0 0 0 mirMAP -0.25 0.00012 NA
35 hsa-miR-32-5p ATP8B1 0 0 0 0 miRNATAP -0.11 0.00287 NA
36 hsa-miR-32-5p ATRX 0 0 0 0 MirTarget; miRNATAP -0.14 0 NA
37 hsa-miR-32-5p ATXN1 0 0 0 0 miRNAWalker2 validate; miRNATAP -0.13 0 NA
38 hsa-miR-32-5p ATXN1L 0 0 0 0 miRNATAP -0.15 0 NA
39 hsa-miR-32-5p B3GALT2 0 0 0 0 MirTarget; miRNATAP -0.17 0.00024 NA
40 hsa-miR-32-5p BAZ2B 0 0 0 0 miRNATAP -0.18 0 NA
41 hsa-miR-32-5p BBX 0 0 0 0 mirMAP -0.12 0 NA
42 hsa-miR-32-5p BCL2L2 0 0 0 0 mirMAP -0.14 0 NA
43 hsa-miR-32-5p BMPR2 0 0 0 0 miRNATAP -0.17 0 NA
44 hsa-miR-32-5p BSN 0 0 0 0 MirTarget; miRNATAP -0.13 0.00398 NA
45 hsa-miR-32-5p BTG2 0 0 0 0 MirTarget; miRNATAP -0.29 0 22266859 Androgen regulated miR 32 targets BTG2 and is overexpressed in castration resistant prostate cancer; In conclusion androgen-regulated miR-32 is overexpressed in CRPC leading to reduced expression of BTG2
46 hsa-miR-32-5p C1orf64 0 0 0 0 mirMAP -0.78 0 NA
47 hsa-miR-32-5p C20orf194 0 0 0 0 miRNATAP -0.25 0 NA
48 hsa-miR-32-5p C2CD2 0 0 0 0 mirMAP -0.21 0 NA
49 hsa-miR-32-5p C2orf72 0 0 0 0 mirMAP -0.21 0.01171 NA
50 hsa-miR-32-5p C6orf120 0 0 0 0 mirMAP -0.1 0 NA
51 hsa-miR-32-5p CACNB4 0 0 0 0 mirMAP -0.3 0 NA
52 hsa-miR-32-5p CADM2 0 0 0 0 MirTarget; mirMAP; miRNATAP -0.47 0 NA
53 hsa-miR-32-5p CALN1 0 0 0 0 miRNATAP -0.69 0 NA
54 hsa-miR-32-5p CBLN4 0 0 0 0 MirTarget; miRNATAP -0.59 0 NA
55 hsa-miR-32-5p CCDC50 0 0 0 0 mirMAP -0.16 0 NA
56 hsa-miR-32-5p CCNJL 0 0 0 0 MirTarget; miRNATAP -0.1 0.02581 NA
57 hsa-miR-32-5p CDC42BPA 0 0 0 0 miRNATAP -0.17 0 NA
58 hsa-miR-32-5p CDKN1C 0 0 0 0 MirTarget; miRNATAP -0.3 0 NA
59 hsa-miR-32-5p CEBPA 0 0 0 0 miRNATAP -0.19 0 NA
60 hsa-miR-32-5p CELF2 0 0 0 0 miRNATAP -0.22 0 NA
61 hsa-miR-32-5p CFL2 0 0 0 0 miRNATAP -0.22 0 NA
62 hsa-miR-32-5p CHD9 0 0 0 0 miRNATAP -0.23 0 NA
63 hsa-miR-32-5p CHST7 0 0 0 0 MirTarget -0.1 0.00016 NA
64 hsa-miR-32-5p CHSY3 0 0 0 0 miRNATAP -0.16 0 NA
65 hsa-miR-32-5p CLDN11 0 0 0 0 MirTarget -0.6 0 NA
66 hsa-miR-32-5p CNTN1 0 0 0 0 miRNATAP -0.66 0 NA
67 hsa-miR-32-5p CNTN4 0 0 0 0 miRNATAP -0.46 0 NA
68 hsa-miR-32-5p COL12A1 0 0 0 0 miRNATAP -0.15 0.00211 NA
69 hsa-miR-32-5p COL1A2 0 0 0 0 MirTarget; miRNATAP -0.11 0.03098 NA
70 hsa-miR-32-5p CPEB1 0 0 0 0 miRNATAP -0.55 0 NA
71 hsa-miR-32-5p CPEB2 0 0 0 0 miRNATAP -0.24 0 NA
72 hsa-miR-32-5p CPEB3 0 0 0 0 MirTarget; miRNATAP -0.17 0 NA
73 hsa-miR-32-5p CPEB4 0 0 0 0 miRNAWalker2 validate; miRNATAP -0.17 0 NA
74 hsa-miR-32-5p CPNE8 0 0 0 0 miRNATAP -0.13 0.0007 NA
75 hsa-miR-32-5p CREB5 0 0 0 0 miRNAWalker2 validate -0.33 0 NA
76 hsa-miR-32-5p CSMD1 0 0 0 0 miRNATAP -0.5 0 NA
77 hsa-miR-32-5p CSRNP3 0 0 0 0 mirMAP -0.59 0 NA
78 hsa-miR-32-5p CTTNBP2 0 0 0 0 miRNATAP -0.56 0 NA
79 hsa-miR-32-5p CXXC5 0 0 0 0 MirTarget -0.12 0.00272 NA
80 hsa-miR-32-5p DAAM1 0 0 0 0 miRNATAP -0.18 0 NA
81 hsa-miR-32-5p DAB2IP 0 0 0 0 MirTarget; miRNATAP -0.14 0 26622795 microRNA 32 induces radioresistance by targeting DAB2IP and regulating autophagy in prostate cancer cells; miR-32 expression was upregulated or overexpressed in PCa and miR-32 inhibited DAB2IP expression through a direct binding site within the DAB2IP 3' untranslated region; More significantly the overexpression of miR-32 and the knockdown of DAB2IP enhanced autophagy in the IR-treated PCa cells; In conclusion these data provide novel insights into the mechanisms governing the regulation of DAB2IP expression by miR-32 and their possible contribution to autophagy and radioresistance in PCa
82 hsa-miR-32-5p DCX 0 0 0 0 miRNATAP -0.24 0.02025 NA
83 hsa-miR-32-5p DDI2 0 0 0 0 mirMAP -0.21 8.0E-5 NA
84 hsa-miR-32-5p DDX3X 0 0 0 0 miRNATAP -0.1 0 NA
85 hsa-miR-32-5p DENND2C 0 0 0 0 mirMAP -0.27 0 NA
86 hsa-miR-32-5p DENND5B 0 0 0 0 mirMAP -0.21 0 NA
87 hsa-miR-32-5p DIO2 0 0 0 0 mirMAP -0.12 0.0263 NA
88 hsa-miR-32-5p DKK3 0 0 0 0 MirTarget -0.37 0 NA
89 hsa-miR-32-5p DLG2 0 0 0 0 mirMAP -0.32 0 NA
90 hsa-miR-32-5p DMXL1 0 0 0 0 MirTarget; miRNATAP -0.2 0 NA
91 hsa-miR-32-5p DOCK5 0 0 0 0 MirTarget -0.12 0.00116 NA
92 hsa-miR-32-5p DOCK9 0 0 0 0 miRNAWalker2 validate; MirTarget -0.17 0 NA
93 hsa-miR-32-5p DOK6 0 0 0 0 mirMAP -0.3 0 NA
94 hsa-miR-32-5p DSC3 0 0 0 0 miRNAWalker2 validate -0.46 1.0E-5 NA
95 hsa-miR-32-5p DSCAML1 0 0 0 0 MirTarget; miRNATAP -0.31 1.0E-5 NA
96 hsa-miR-32-5p DSEL 0 0 0 0 mirMAP -0.45 0 NA
97 hsa-miR-32-5p DST 0 0 0 0 miRNAWalker2 validate; mirMAP -0.47 0 NA
98 hsa-miR-32-5p DUSP19 0 0 0 0 mirMAP -0.11 0 NA
99 hsa-miR-32-5p EGR2 0 0 0 0 miRNATAP -0.38 0 NA
100 hsa-miR-32-5p EIF5A2 0 0 0 0 mirMAP -0.11 0.00024 NA
101 hsa-miR-32-5p ESRRG 0 0 0 0 miRNATAP -0.19 0.00553 NA
102 hsa-miR-32-5p FAM110B 0 0 0 0 MirTarget -0.12 0.00428 NA
103 hsa-miR-32-5p FAM124A 0 0 0 0 mirMAP -0.12 0.00217 NA
104 hsa-miR-32-5p FAM135A 0 0 0 0 MirTarget; miRNATAP -0.11 0.00339 NA
105 hsa-miR-32-5p FAM150B 0 0 0 0 MirTarget -0.28 0.00216 NA
106 hsa-miR-32-5p FAM160B1 0 0 0 0 miRNATAP -0.13 0 NA
107 hsa-miR-32-5p FAM189A1 0 0 0 0 mirMAP -0.26 0.00072 NA
108 hsa-miR-32-5p FAM198A 0 0 0 0 mirMAP -0.13 0.00859 NA
109 hsa-miR-32-5p FAT3 0 0 0 0 mirMAP -0.56 0 NA
110 hsa-miR-32-5p FCHO2 0 0 0 0 miRNATAP -0.16 0 NA
111 hsa-miR-32-5p FEM1B 0 0 0 0 mirMAP -0.12 0 NA
112 hsa-miR-32-5p FGF2 0 0 0 0 miRNAWalker2 validate -0.6 0 NA
113 hsa-miR-32-5p FHL2 0 0 0 0 miRNATAP -0.25 0 NA
114 hsa-miR-32-5p FITM2 0 0 0 0 mirMAP -0.16 0 NA
115 hsa-miR-32-5p FLI1 0 0 0 0 miRNATAP -0.15 0 NA
116 hsa-miR-32-5p FMN2 0 0 0 0 miRNATAP -0.41 0 NA
117 hsa-miR-32-5p FNIP1 0 0 0 0 MirTarget; miRNATAP -0.16 0 NA
118 hsa-miR-32-5p FOXN3 0 0 0 0 miRNATAP -0.25 0 NA
119 hsa-miR-32-5p FOXP1 0 0 0 0 miRNATAP -0.12 0 NA
120 hsa-miR-32-5p FOXP2 0 0 0 0 miRNATAP -0.52 0 NA
121 hsa-miR-32-5p FRMPD2 0 0 0 0 mirMAP -0.57 0 NA
122 hsa-miR-32-5p FRY 0 0 0 0 MirTarget; miRNATAP -0.34 0 NA
123 hsa-miR-32-5p FRYL 0 0 0 0 miRNATAP -0.11 1.0E-5 NA
124 hsa-miR-32-5p FTO 0 0 0 0 mirMAP -0.18 0 NA
125 hsa-miR-32-5p FYCO1 0 0 0 0 mirMAP -0.23 0 NA
126 hsa-miR-32-5p FZD10 0 0 0 0 miRNATAP -0.12 0.01564 NA
127 hsa-miR-32-5p FZD4 0 0 0 0 mirMAP -0.39 0 NA
128 hsa-miR-32-5p GAP43 0 0 0 0 miRNATAP -0.2 7.0E-5 NA
129 hsa-miR-32-5p GATA2 0 0 0 0 MirTarget; miRNATAP -0.26 0 NA
130 hsa-miR-32-5p GFPT2 0 0 0 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.12 0.00274 NA
131 hsa-miR-32-5p GLCE 0 0 0 0 miRNATAP -0.11 0.00026 NA
132 hsa-miR-32-5p GLDN 0 0 0 0 mirMAP -0.43 0 NA
133 hsa-miR-32-5p GLI3 0 0 0 0 mirMAP -0.29 0 NA
134 hsa-miR-32-5p GNAQ 0 0 0 0 MirTarget -0.12 0 NA
135 hsa-miR-32-5p GPC6 0 0 0 0 MirTarget -0.24 1.0E-5 NA
136 hsa-miR-32-5p GPRIN2 0 0 0 0 mirMAP -0.18 0.04787 NA
137 hsa-miR-32-5p GRAMD3 0 0 0 0 MirTarget; miRNATAP -0.23 0 NA
138 hsa-miR-32-5p GRIA3 0 0 0 0 MirTarget; miRNATAP -0.43 0 NA
139 hsa-miR-32-5p GRIK3 0 0 0 0 mirMAP -0.52 0 NA
140 hsa-miR-32-5p GRK5 0 0 0 0 miRNATAP -0.17 0 NA
141 hsa-miR-32-5p GTF2A1 0 0 0 0 MirTarget; miRNATAP -0.19 3.0E-5 NA
142 hsa-miR-32-5p HAND2 0 0 0 0 miRNATAP -0.29 0 NA
143 hsa-miR-32-5p HAS3 0 0 0 0 miRNATAP -0.46 0 NA
144 hsa-miR-32-5p HERC2 0 0 0 0 MirTarget -0.11 0 NA
145 hsa-miR-32-5p HFE 0 0 0 0 mirMAP -0.24 0 NA
146 hsa-miR-32-5p HIPK3 0 0 0 0 MirTarget; miRNATAP -0.31 0 NA
147 hsa-miR-32-5p HMBOX1 0 0 0 0 miRNATAP -0.18 0 NA
148 hsa-miR-32-5p HOXA9 0 0 0 0 miRNATAP -0.42 0 NA
149 hsa-miR-32-5p HOXB8 0 0 0 0 miRNATAP -0.24 3.0E-5 NA
150 hsa-miR-32-5p HOXC8 0 0 0 0 miRNATAP -0.11 0.00026 NA
NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 73 1402 1.503e-15 3.497e-12
2 NEURON DIFFERENTIATION 56 874 9.109e-16 3.497e-12
3 CELL DEVELOPMENT 72 1426 1.179e-14 1.828e-11
4 NEURON DEVELOPMENT 44 687 1.504e-12 1.749e-09
5 CENTRAL NERVOUS SYSTEM DEVELOPMENT 50 872 2.482e-12 2.309e-09
6 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 77 1805 7.153e-12 4.775e-09
7 POSITIVE REGULATION OF GENE EXPRESSION 75 1733 7.183e-12 4.775e-09
8 HEAD DEVELOPMENT 43 709 1.637e-11 9.52e-09
9 REGULATION OF CELL DIFFERENTIATION 67 1492 2.423e-11 1.253e-08
10 FOREBRAIN DEVELOPMENT 28 357 2.366e-10 1.101e-07
11 NEURON PROJECTION DEVELOPMENT 35 545 3.135e-10 1.216e-07
12 BEHAVIOR 34 516 2.908e-10 1.216e-07
13 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 69 1672 4.722e-10 1.617e-07
14 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 72 1784 4.866e-10 1.617e-07
15 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 13 70 5.736e-10 1.779e-07
16 RESPONSE TO ENDOGENOUS STIMULUS 62 1450 1.082e-09 3.146e-07
17 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 18 166 2.725e-09 7.46e-07
18 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 48 1008 3.745e-09 9.68e-07
19 PALLIUM DEVELOPMENT 17 153 5.206e-09 1.188e-06
20 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 50 1087 5.362e-09 1.188e-06
21 REGULATION OF PHOSPHORUS METABOLIC PROCESS 65 1618 4.852e-09 1.188e-06
22 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 39 740 8.243e-09 1.743e-06
23 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 47 1004 9.442e-09 1.91e-06
24 HIPPOCAMPUS DEVELOPMENT 12 73 1.138e-08 2.206e-06
25 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 32 541 1.358e-08 2.378e-06
26 NEURON PROJECTION MORPHOGENESIS 27 402 1.423e-08 2.378e-06
27 TELENCEPHALON DEVELOPMENT 20 228 1.431e-08 2.378e-06
28 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 32 541 1.358e-08 2.378e-06
29 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 61 1517 1.521e-08 2.44e-06
30 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 15 126 1.632e-08 2.531e-06
31 POSITIVE REGULATION OF NEURON DIFFERENTIATION 23 306 2.204e-08 3.309e-06
32 CELLULAR COMPONENT MORPHOGENESIS 43 900 2.392e-08 3.478e-06
33 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 34 616 2.596e-08 3.66e-06
34 NEGATIVE REGULATION OF MOLECULAR FUNCTION 48 1079 3.173e-08 4.343e-06
35 POSITIVE REGULATION OF CATALYTIC ACTIVITY 60 1518 3.774e-08 5.017e-06
36 CARDIOVASCULAR SYSTEM DEVELOPMENT 39 788 4.479e-08 5.633e-06
37 CIRCULATORY SYSTEM DEVELOPMENT 39 788 4.479e-08 5.633e-06
38 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 44 957 4.938e-08 5.849e-06
39 NEGATIVE REGULATION OF GENE EXPRESSION 59 1493 5.032e-08 5.849e-06
40 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 30 513 5.052e-08 5.849e-06
41 LIMBIC SYSTEM DEVELOPMENT 13 100 5.154e-08 5.849e-06
42 RESPONSE TO HORMONE 42 893 5.471e-08 6.061e-06
43 CELLULAR RESPONSE TO HORMONE STIMULUS 31 552 7.479e-08 8.093e-06
44 REGULATION OF NEURON DIFFERENTIATION 31 554 8.109e-08 8.575e-06
45 REGULATION OF PROTEIN MODIFICATION PROCESS 64 1710 9.318e-08 9.635e-06
46 POSITIVE REGULATION OF MOLECULAR FUNCTION 66 1791 1.006e-07 9.961e-06
47 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 19 232 9.878e-08 9.961e-06
48 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 24 368 1.591e-07 1.542e-05
49 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 48 1142 1.755e-07 1.667e-05
50 CELL PROJECTION ORGANIZATION 41 902 1.99e-07 1.852e-05
51 RHYTHMIC PROCESS 21 298 2.692e-07 2.456e-05
52 INTRACELLULAR SIGNAL TRANSDUCTION 59 1572 2.945e-07 2.635e-05
53 SINGLE ORGANISM BEHAVIOR 24 384 3.465e-07 3.042e-05
54 REGULATION OF CELL DEATH 56 1472 4.014e-07 3.459e-05
55 REGULATION OF HYDROLASE ACTIVITY 52 1327 4.53e-07 3.833e-05
56 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 38 829 4.669e-07 3.879e-05
57 EMBRYONIC MORPHOGENESIS 29 539 4.859e-07 3.966e-05
58 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 37 799 5.222e-07 4.189e-05
59 NEGATIVE REGULATION OF PHOSPHORYLATION 25 422 5.344e-07 4.215e-05
60 REGULATION OF CELL DEVELOPMENT 38 836 5.741e-07 4.452e-05
61 SKELETAL SYSTEM DEVELOPMENT 26 455 6.271e-07 4.77e-05
62 REGULATION OF GTPASE ACTIVITY 33 673 6.356e-07 4.77e-05
63 POSITIVE REGULATION OF AXONOGENESIS 10 69 6.514e-07 4.811e-05
64 ORGAN MORPHOGENESIS 38 841 6.642e-07 4.829e-05
65 HEART DEVELOPMENT 26 466 9.825e-07 7.033e-05
66 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 25 437 1.014e-06 7.146e-05
67 POSITIVE REGULATION OF CELL DIFFERENTIATION 37 823 1.06e-06 7.359e-05
68 RESPONSE TO NITROGEN COMPOUND 38 859 1.11e-06 7.596e-05
69 POSITIVE REGULATION OF CELL DEVELOPMENT 26 472 1.247e-06 8.409e-05
70 NEGATIVE REGULATION OF KINASE ACTIVITY 18 250 1.421e-06 9.444e-05
71 RESPONSE TO OXYGEN CONTAINING COMPOUND 52 1381 1.496e-06 9.723e-05
72 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 36 801 1.504e-06 9.723e-05
73 NEGATIVE REGULATION OF CELL DEATH 38 872 1.591e-06 0.0001014
74 CARDIOCYTE DIFFERENTIATION 11 96 1.993e-06 0.0001253
75 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 34 750 2.472e-06 0.0001533
76 MUSCLE STRUCTURE DEVELOPMENT 24 432 2.782e-06 0.0001703
77 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 33 724 3.115e-06 0.0001883
78 VASCULATURE DEVELOPMENT 25 469 3.587e-06 0.000214
79 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 25 470 3.724e-06 0.0002193
80 POSITIVE REGULATION OF HYDROLASE ACTIVITY 38 905 3.815e-06 0.0002219
81 REGULATION OF CELLULAR COMPONENT BIOGENESIS 34 767 4.02e-06 0.0002309
82 CELL PART MORPHOGENESIS 30 633 4.137e-06 0.000234
83 APPENDAGE DEVELOPMENT 14 169 4.224e-06 0.000234
84 LIMB DEVELOPMENT 14 169 4.224e-06 0.000234
85 REGULATION OF TRANSFERASE ACTIVITY 39 946 4.358e-06 0.0002385
86 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 51 1395 4.427e-06 0.0002385
87 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 40 983 4.458e-06 0.0002385
88 CEREBRAL CORTEX DEVELOPMENT 11 105 4.839e-06 0.0002558
89 TISSUE DEVELOPMENT 54 1518 4.993e-06 0.000261
90 REGULATION OF KINASE ACTIVITY 34 776 5.164e-06 0.0002645
91 RESPONSE TO ORGANIC CYCLIC COMPOUND 38 917 5.174e-06 0.0002645
92 NEGATIVE REGULATION OF CELL DIFFERENTIATION 29 609 5.487e-06 0.0002775
93 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 19 303 5.58e-06 0.0002792
94 CELLULAR RESPONSE TO LIPID 24 457 7.234e-06 0.0003434
95 EMBRYO DEVELOPMENT 37 894 7.132e-06 0.0003434
96 TUBE DEVELOPMENT 27 552 7.177e-06 0.0003434
97 CELL FATE COMMITMENT 16 227 7.16e-06 0.0003434
98 GLAND DEVELOPMENT 22 395 6.971e-06 0.0003434
99 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 27 554 7.664e-06 0.0003602
100 LOCOMOTORY BEHAVIOR 14 181 9.343e-06 0.0004304
101 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 6 27 9.266e-06 0.0004304
102 ADULT BEHAVIOR 12 135 1.001e-05 0.0004567
103 REPRODUCTIVE SYSTEM DEVELOPMENT 22 408 1.159e-05 0.0005183
104 REGULATION OF NEURON PROJECTION DEVELOPMENT 22 408 1.159e-05 0.0005183
105 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 1.205e-05 0.0005341
106 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 162 1.31e-05 0.0005752
107 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 52 1492 1.347e-05 0.0005856
108 RESPONSE TO LIPID 36 888 1.491e-05 0.0006425
109 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 43 1152 1.63e-05 0.0006958
110 MUSCLE TISSUE DEVELOPMENT 17 275 2.082e-05 0.0008806
111 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 60 1848 2.323e-05 0.0009738
112 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 337 2.491e-05 0.001035
113 CHEMICAL HOMEOSTASIS 35 874 2.541e-05 0.001044
114 REGULATION OF CIRCADIAN RHYTHM 10 103 2.558e-05 0.001044
115 CELLULAR RESPONSE TO ACID CHEMICAL 13 175 2.978e-05 0.001205
116 NEURON RECOGNITION 6 33 3.151e-05 0.001264
117 FOREBRAIN GENERATION OF NEURONS 8 66 3.337e-05 0.001316
118 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 27 602 3.327e-05 0.001316
119 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 39 1036 3.438e-05 0.001333
120 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 39 1036 3.438e-05 0.001333
121 CELLULAR RESPONSE TO NITROGEN COMPOUND 24 505 3.69e-05 0.001419
122 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 19 351 4.336e-05 0.001654
123 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 47 1360 4.497e-05 0.001701
124 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 5 22 4.745e-05 0.00178
125 POSITIVE REGULATION OF LOCOMOTION 21 420 5.507e-05 0.002048
126 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 38 1021 5.545e-05 0.002048
127 RESPONSE TO ABIOTIC STIMULUS 38 1024 5.899e-05 0.002161
128 CIRCADIAN RHYTHM 11 137 6.006e-05 0.002183
129 CARDIAC MUSCLE TISSUE DEVELOPMENT 11 140 7.314e-05 0.002638
130 REGULATION OF EPITHELIAL CELL MIGRATION 12 166 7.807e-05 0.002724
131 PERIPHERAL NERVOUS SYSTEM NEURON DIFFERENTIATION 4 13 7.845e-05 0.002724
132 LOCOMOTION 40 1114 7.674e-05 0.002724
133 PERIPHERAL NERVOUS SYSTEM NEURON DEVELOPMENT 4 13 7.845e-05 0.002724
134 REGULATION OF CYTOPLASMIC TRANSLATION 4 13 7.845e-05 0.002724
135 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 22 465 8.293e-05 0.002837
136 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 44 1275 8.284e-05 0.002837
137 CYCLIC NUCLEOTIDE METABOLIC PROCESS 7 57 9.555e-05 0.003245
138 IN UTERO EMBRYONIC DEVELOPMENT 17 311 9.666e-05 0.003259
139 FORELIMB MORPHOGENESIS 6 40 9.767e-05 0.003269
140 REGULATION OF ACTIN FILAMENT BASED PROCESS 17 312 0.0001005 0.003316
141 REGULATION OF LIPID METABOLIC PROCESS 16 282 0.0001003 0.003316
142 LAYER FORMATION IN CEREBRAL CORTEX 4 14 0.0001082 0.003472
143 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 7 58 0.0001069 0.003472
144 REGULATION OF SYSTEM PROCESS 23 507 0.0001076 0.003472
145 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 4 14 0.0001082 0.003472
146 REGULATION OF LIPID STORAGE 6 41 0.0001126 0.003589
147 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 13 204 0.000143 0.004526
148 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 103 0.0001471 0.004624
149 BIOLOGICAL ADHESION 37 1032 0.0001485 0.004636
150 NEGATIVE REGULATION OF LOCOMOTION 15 263 0.0001553 0.004817
151 NEGATIVE REGULATION OF CELL COMMUNICATION 41 1192 0.0001574 0.00485
152 REGULATION OF CELLULAR COMPONENT MOVEMENT 30 771 0.0001614 0.004921
153 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 11 153 0.0001618 0.004921
154 ODONTOGENESIS 9 105 0.0001704 0.005148
155 REGULATION OF CELL PROJECTION ORGANIZATION 24 558 0.0001715 0.005149
156 SEX DIFFERENTIATION 15 266 0.0001758 0.005243
157 MUSCLE CELL DIFFERENTIATION 14 237 0.000178 0.005276
158 EPIDERMIS MORPHOGENESIS 5 29 0.0001919 0.005513
159 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 11 156 0.0001919 0.005513
160 RESPONSE TO ARSENIC CONTAINING SUBSTANCE 5 29 0.0001919 0.005513
161 RESPONSE TO SALT 4 16 0.0001909 0.005513
162 REGULATION OF FATTY ACID BETA OXIDATION 4 16 0.0001909 0.005513
163 RESPONSE TO WOUNDING 24 563 0.0001958 0.00559
164 RESPONSE TO STEROID HORMONE 22 497 0.0002138 0.006013
165 HORMONE MEDIATED SIGNALING PATHWAY 11 158 0.0002145 0.006013
166 BLOOD VESSEL MORPHOGENESIS 18 364 0.0002128 0.006013
167 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 6 46 0.0002167 0.006037
168 POSITIVE REGULATION OF CELL DEATH 25 605 0.0002324 0.006437
169 CAMP BIOSYNTHETIC PROCESS 4 17 0.0002459 0.006692
170 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 4 17 0.0002459 0.006692
171 NEGATIVE REGULATION OF CELL PROLIFERATION 26 643 0.000245 0.006692
172 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 7 67 0.0002674 0.007192
173 NEURON FATE COMMITMENT 7 67 0.0002674 0.007192
174 RESPONSE TO PEPTIDE 19 404 0.0002703 0.007229
175 MUSCLE ORGAN DEVELOPMENT 15 277 0.0002722 0.007237
176 REGULATION OF BODY FLUID LEVELS 22 506 0.0002742 0.00725
177 REGULATION OF OSTEOBLAST DIFFERENTIATION 9 112 0.0002775 0.007296
178 HINDBRAIN DEVELOPMENT 10 137 0.0002822 0.007337
179 POSITIVE REGULATION OF CAMP METABOLIC PROCESS 8 89 0.0002816 0.007337
180 RESPONSE TO OXYGEN LEVELS 16 311 0.0003054 0.007852
181 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 25 616 0.0003045 0.007852
182 NEGATIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 5 32 0.0003107 0.007921
183 REGULATION OF B CELL APOPTOTIC PROCESS 4 18 0.0003115 0.007921
184 REGULATION OF ENDOTHELIAL CELL MIGRATION 9 114 0.0003168 0.008011
185 WATER HOMEOSTASIS 7 70 0.0003512 0.008833
186 FEMALE SEX DIFFERENTIATION 9 116 0.0003605 0.009018
187 REGULATION OF AXONOGENESIS 11 168 0.0003643 0.009064
188 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 51 1656 0.0003671 0.009066
189 REGULATION OF EPITHELIAL CELL PROLIFERATION 15 285 0.0003682 0.009066
190 RESPIRATORY SYSTEM DEVELOPMENT 12 197 0.0003862 0.009457
191 RESPONSE TO ACID CHEMICAL 16 319 0.0004043 0.009848
192 FOREBRAIN NEURON DEVELOPMENT 5 34 0.0004162 0.009931
193 RENAL WATER HOMEOSTASIS 5 34 0.0004162 0.009931
194 CAMP METABOLIC PROCESS 5 34 0.0004162 0.009931
195 REGULATION OF CELL PROLIFERATION 47 1496 0.0004114 0.009931
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 56 1199 3.232e-10 3.003e-07
2 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 37 629 1.091e-09 3.475e-07
3 SEQUENCE SPECIFIC DNA BINDING 50 1037 1.122e-09 3.475e-07
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 25 328 4.006e-09 9.304e-07
5 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 22 315 1.629e-07 3.027e-05
6 DOUBLE STRANDED DNA BINDING 36 764 4.979e-07 7.71e-05
7 MACROMOLECULAR COMPLEX BINDING 53 1399 9.739e-07 0.0001292
8 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 17 226 1.532e-06 0.0001779
9 REGULATORY REGION NUCLEIC ACID BINDING 36 818 2.433e-06 0.0002347
10 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 29 588 2.779e-06 0.0002347
11 TRANSCRIPTION FACTOR BINDING 27 524 2.754e-06 0.0002347
12 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 19 303 5.58e-06 0.0004319
13 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 12 133 8.59e-06 0.0005788
14 PROTEIN DOMAIN SPECIFIC BINDING 29 624 8.723e-06 0.0005788
15 ENZYME BINDING 58 1737 1.443e-05 0.000894
16 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 6 30 1.772e-05 0.001029
17 MOLECULAR FUNCTION REGULATOR 48 1353 1.908e-05 0.001042
18 X14 3 3 PROTEIN BINDING 5 19 2.195e-05 0.001133
19 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 10 104 2.784e-05 0.001361
20 PHOSPHATIDYLSERINE BINDING 6 33 3.151e-05 0.001463
21 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 14 228 0.0001187 0.005252
22 PHOSPHOLIPID BINDING 18 360 0.0001858 0.007847
23 KINASE BINDING 25 606 0.0002383 0.00942
24 MODIFIED AMINO ACID BINDING 7 66 0.0002434 0.00942
25 CORE PROMOTER PROXIMAL REGION DNA BINDING 18 371 0.0002681 0.009964
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 49 942 1.302e-10 7.606e-08
2 NEURON PART 55 1265 6.13e-09 1.79e-06
3 CELL PROJECTION 66 1786 9.068e-08 1.765e-05
4 CELL JUNCTION 48 1151 2.212e-07 3.23e-05
5 AXON 25 418 4.481e-07 5.234e-05
6 SOMATODENDRITIC COMPARTMENT 31 650 2.502e-06 0.0002435
7 EXCITATORY SYNAPSE 15 197 5.449e-06 0.0004546
8 SYNAPSE 33 754 7.31e-06 0.0005336
9 CYTOPLASMIC REGION 17 287 3.581e-05 0.002323
10 CELL CORTEX 15 238 5.084e-05 0.002814
11 DENDRITE 22 451 5.3e-05 0.002814
12 NEURONAL POSTSYNAPTIC DENSITY 7 53 5.943e-05 0.002892
13 CELL BODY 23 494 7.305e-05 0.003282
14 POSTSYNAPSE 19 378 0.0001157 0.004814
15 CELL PROJECTION PART 35 946 0.0001236 0.004814

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Hippo_signaling_pathway_hsa04390 11 154 0.0001714 0.00499
2 Hippo_signaling_pathway_multiple_species_hsa04392 5 29 0.0001919 0.00499
3 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 10 139 0.0003172 0.005255
4 cAMP_signaling_pathway_hsa04024 12 198 0.0004043 0.005255
5 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.001101 0.01039
6 Apelin_signaling_pathway_hsa04371 9 137 0.001199 0.01039
7 Oocyte_meiosis_hsa04114 8 124 0.002484 0.01845
8 ECM_receptor_interaction_hsa04512 5 82 0.01959 0.118
9 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.02047 0.118
10 Calcium_signaling_pathway_hsa04020 8 182 0.0227 0.118
11 Gap_junction_hsa04540 5 88 0.02569 0.1214
12 Neuroactive_ligand_receptor_interaction_hsa04080 10 278 0.03932 0.1582
13 FoxO_signaling_pathway_hsa04068 6 132 0.03955 0.1582
14 Wnt_signaling_pathway_hsa04310 6 146 0.05913 0.2196
15 Focal_adhesion_hsa04510 7 199 0.08431 0.2923
16 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.1005 0.3268
17 p53_signaling_pathway_hsa04115 3 68 0.1376 0.421
18 TNF_signaling_pathway_hsa04668 4 108 0.1482 0.4281
19 mTOR_signaling_pathway_hsa04150 5 151 0.1584 0.4334
20 Sphingolipid_signaling_pathway_hsa04071 4 118 0.1847 0.4636
21 Rap1_signaling_pathway_hsa04015 6 206 0.1959 0.4636
22 AMPK_signaling_pathway_hsa04152 4 121 0.1962 0.4636
23 TGF_beta_signaling_pathway_hsa04350 3 84 0.2122 0.4797
24 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.288 0.6205
25 Phospholipase_D_signaling_pathway_hsa04072 4 146 0.2983 0.6205
26 Mitophagy_animal_hsa04137 2 65 0.3486 0.6716
27 PI3K_Akt_signaling_pathway_hsa04151 8 352 0.3487 0.6716
28 Tight_junction_hsa04530 4 170 0.401 0.7447
29 Autophagy_animal_hsa04140 3 128 0.4367 0.783
30 ErbB_signaling_pathway_hsa04012 2 85 0.4794 0.7974
31 Apoptosis_hsa04210 3 138 0.4856 0.7974
32 Endocytosis_hsa04144 5 244 0.4907 0.7974
33 Phagosome_hsa04145 3 152 0.5504 0.8671
34 Cellular_senescence_hsa04218 3 160 0.5852 0.8671
35 MAPK_signaling_pathway_hsa04010 5 295 0.6582 0.925
36 Cell_cycle_hsa04110 2 124 0.6829 0.9345
37 Jak_STAT_signaling_pathway_hsa04630 2 162 0.8139 1
38 Ras_signaling_pathway_hsa04014 3 232 0.8174 1

Quest ID: b8fdab1dcb003ec38ef164f6e25533f1