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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-148a-3p A4GNT -0.75 0 -1.24 0.00042 MirTarget -0.73 0 NA
2 hsa-miR-148a-5p ABCB5 -0.77 0 1.74 1.0E-5 mirMAP -0.57 0 NA
3 hsa-miR-148a-5p ABCC5 -0.77 0 1.23 0 mirMAP -0.21 0 NA
4 hsa-miR-148a-5p ABI2 -0.77 0 0.14 0.17339 miRNATAP -0.24 0 NA
5 hsa-miR-148a-3p ACHE -0.75 0 0.07 0.84522 miRNATAP -0.64 0 NA
6 hsa-miR-148a-3p ACSL4 -0.75 0 2.07 0 miRNATAP -0.65 0 NA
7 hsa-miR-148a-5p ACTG1 -0.77 0 -0.12 0.20938 MirTarget; miRNATAP -0.17 0 NA
8 hsa-miR-148a-5p ACTR3 -0.77 0 0.05 0.43435 mirMAP -0.12 0 NA
9 hsa-miR-148a-3p ACVR1 -0.75 0 -0.44 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.0001 NA
10 hsa-miR-148a-3p ADAM10 -0.75 0 -0 0.9783 MirTarget -0.11 0.02275 NA
11 hsa-miR-148a-3p ADAM19 -0.75 0 -0.32 0.02321 mirMAP -0.33 0 NA
12 hsa-miR-148a-3p ADAM22 -0.75 0 1.17 0.00038 MirTarget; miRNATAP -0.57 0 NA
13 hsa-miR-148a-3p ADAM23 -0.75 0 1.53 0.00013 MirTarget -0.47 0.00032 NA
14 hsa-miR-148a-3p ADAMTS15 -0.75 0 -0.88 0.00206 MirTarget; miRNATAP -0.41 1.0E-5 NA
15 hsa-miR-148a-5p ADAMTS15 -0.77 0 -0.88 0.00206 mirMAP -0.4 1.0E-5 NA
16 hsa-miR-148a-3p ADAMTS18 -0.75 0 1.44 1.0E-5 miRNATAP -0.21 0.04667 NA
17 hsa-miR-148a-3p ADAMTS5 -0.75 0 -0.16 0.36499 miRNATAP -0.31 0 NA
18 hsa-miR-148a-5p ADAMTS5 -0.77 0 -0.16 0.36499 mirMAP; miRNATAP -0.31 0 NA
19 hsa-miR-148a-3p ADM2 -0.75 0 1.72 0 mirMAP -0.43 0 NA
20 hsa-miR-148a-3p ADPRH -0.75 0 -0.13 0.2674 MirTarget -0.25 0 NA
21 hsa-miR-148a-5p ADSS -0.77 0 0.31 0.00033 MirTarget -0.11 4.0E-5 NA
22 hsa-miR-148a-5p AGPAT4 -0.77 0 0.87 7.0E-5 mirMAP -0.25 0.00016 NA
23 hsa-miR-148a-3p AHDC1 -0.75 0 -0.23 0.02626 miRNATAP -0.12 0.00053 NA
24 hsa-miR-148a-5p ALPK3 -0.77 0 1.32 0 mirMAP -0.3 0.00022 NA
25 hsa-miR-148a-3p AMZ1 -0.75 0 -1.28 0.00014 mirMAP -0.44 6.0E-5 NA
26 hsa-miR-148a-3p ANK2 -0.75 0 -0.94 8.0E-5 MirTarget; miRNATAP -0.44 0 NA
27 hsa-miR-148a-5p ANK2 -0.77 0 -0.94 8.0E-5 MirTarget; miRNATAP -0.3 4.0E-5 NA
28 hsa-miR-148a-3p ANKRD27 -0.75 0 0.9 0 mirMAP -0.18 0 NA
29 hsa-miR-148a-3p ANKRD52 -0.75 0 1.46 0 mirMAP; miRNATAP -0.25 0 NA
30 hsa-miR-148a-5p ANKRD52 -0.77 0 1.46 0 miRNATAP -0.2 0 NA
31 hsa-miR-148a-3p ANKS6 -0.75 0 0.76 0.01521 mirMAP -0.63 0 NA
32 hsa-miR-148a-3p ANXA4 -0.75 0 -0.2 0.167 MirTarget -0.36 0 NA
33 hsa-miR-148a-3p ARAP2 -0.75 0 -1.13 0 MirTarget -0.26 0 NA
34 hsa-miR-148a-5p ARHGAP31 -0.77 0 -0.42 0.00347 mirMAP -0.14 0.00129 NA
35 hsa-miR-148a-3p ARHGEF17 -0.75 0 0.06 0.69914 miRNATAP -0.46 0 NA
36 hsa-miR-148a-5p ARHGEF18 -0.77 0 0.5 0 MirTarget; miRNATAP -0.12 0 NA
37 hsa-miR-148a-5p ARID5B -0.77 0 -0.52 0.00012 mirMAP -0.17 3.0E-5 NA
38 hsa-miR-148a-5p ASAH1 -0.77 0 -0.44 0.00056 MirTarget; miRNATAP -0.22 0 NA
39 hsa-miR-148a-3p ATG4D -0.75 0 0.24 0.03588 MirTarget -0.18 0 NA
40 hsa-miR-148a-3p ATP11A -0.75 0 0.19 0.15998 MirTarget -0.17 0.00011 NA
41 hsa-miR-148a-3p ATP2B4 -0.75 0 0.27 0.06736 MirTarget; miRNATAP -0.11 0.02111 NA
42 hsa-miR-148a-3p ATP7A -0.75 0 0.25 0.01885 MirTarget; miRNATAP -0.12 0.00074 NA
43 hsa-miR-148a-3p AURKB -0.75 0 3.49 0 miRNAWalker2 validate -0.53 0 NA
44 hsa-miR-148a-3p B4GALT2 -0.75 0 0.26 0.00786 miRNATAP -0.13 3.0E-5 NA
45 hsa-miR-148a-3p B4GALT5 -0.75 0 -0.52 0 MirTarget; miRNATAP -0.33 0 NA
46 hsa-miR-148a-3p BAZ2A -0.75 0 0.46 0 mirMAP; miRNATAP -0.15 0 NA
47 hsa-miR-148a-3p BCL2 -0.75 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 21455217; 23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a
48 hsa-miR-148a-3p BCL9L -0.75 0 0.49 7.0E-5 mirMAP -0.25 0 NA
49 hsa-miR-148a-5p BDNF -0.77 0 0.05 0.83189 mirMAP -0.26 0.00044 NA
50 hsa-miR-148a-3p BHLHE41 -0.75 0 -0.4 0.15906 MirTarget -0.82 0 NA
51 hsa-miR-148a-5p BICD1 -0.77 0 0.8 0.0004 mirMAP -0.4 0 NA
52 hsa-miR-148a-3p BMF -0.75 0 0.48 0.01823 mirMAP -0.31 0 NA
53 hsa-miR-148a-3p BTBD10 -0.75 0 0.28 2.0E-5 MirTarget; miRNATAP -0.17 0 NA
54 hsa-miR-148a-3p BTBD3 -0.75 0 0.3 0.00861 miRNAWalker2 validate; miRNATAP -0.17 1.0E-5 NA
55 hsa-miR-148a-3p C1orf116 -0.75 0 -1.07 0.0053 mirMAP -0.61 0 NA
56 hsa-miR-148a-5p C3orf14 -0.77 0 -0.24 0.47117 mirMAP -0.29 0.00417 NA
57 hsa-miR-148a-5p C5AR1 -0.77 0 -1.17 0 mirMAP -0.18 0.00087 NA
58 hsa-miR-148a-3p C5orf30 -0.75 0 0.91 0.00049 miRNATAP -0.74 0 NA
59 hsa-miR-148a-5p CA12 -0.77 0 2.34 0 MirTarget -0.98 0 NA
60 hsa-miR-148a-5p CACNA1D -0.77 0 0.08 0.77567 MirTarget; miRNATAP -0.49 0 NA
61 hsa-miR-148a-3p CACNA1E -0.75 0 1.61 4.0E-5 mirMAP -0.55 2.0E-5 NA
62 hsa-miR-148a-5p CACNA1E -0.77 0 1.61 4.0E-5 mirMAP -0.5 3.0E-5 NA
63 hsa-miR-148a-3p CASZ1 -0.75 0 0.04 0.75925 miRNATAP -0.22 0 NA
64 hsa-miR-148a-3p CBFA2T2 -0.75 0 1.21 0 mirMAP -0.14 8.0E-5 NA
65 hsa-miR-148a-5p CBFA2T2 -0.77 0 1.21 0 mirMAP -0.11 0.00103 NA
66 hsa-miR-148a-3p CBX5 -0.75 0 0.35 0.00158 mirMAP -0.15 2.0E-5 NA
67 hsa-miR-148a-3p CCDC6 -0.75 0 0.05 0.48713 MirTarget -0.16 0 NA
68 hsa-miR-148a-5p CCDC6 -0.77 0 0.05 0.48713 MirTarget -0.13 0 NA
69 hsa-miR-148a-3p CCDC85A -0.75 0 0.74 9.0E-5 miRNATAP -0.16 0.00895 NA
70 hsa-miR-148a-5p CCDC93 -0.77 0 1.03 0 mirMAP -0.16 0 NA
71 hsa-miR-148a-3p CCT6A -0.75 0 0.81 0 MirTarget -0.14 0 NA
72 hsa-miR-148a-5p CD109 -0.77 0 1.84 0 mirMAP -0.35 4.0E-5 NA
73 hsa-miR-148a-5p CD2AP -0.77 0 0.18 0.04226 mirMAP -0.14 0 NA
74 hsa-miR-148a-5p CD44 -0.77 0 -0.09 0.71793 mirMAP -0.31 2.0E-5 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity
75 hsa-miR-148a-5p CD93 -0.77 0 0.15 0.24648 mirMAP -0.24 0 NA
76 hsa-miR-148a-3p CDC25B -0.75 0 0.8 0 miRNAWalker2 validate; miRNATAP -0.29 0 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor
77 hsa-miR-148a-3p CDK19 -0.75 0 0.12 0.29406 miRNAWalker2 validate; MirTarget; miRNATAP -0.24 0 NA
78 hsa-miR-148a-3p CDK5R1 -0.75 0 1.08 0 MirTarget; miRNATAP -0.17 0.00187 NA
79 hsa-miR-148a-3p CDS1 -0.75 0 -0.32 0.40167 miRNATAP -0.62 0 NA
80 hsa-miR-148a-5p CECR6 -0.77 0 0.39 0.03999 mirMAP -0.36 0 NA
81 hsa-miR-148a-3p CELSR1 -0.75 0 0.36 0.10713 MirTarget -0.21 0.00487 NA
82 hsa-miR-148a-3p CENPP -0.75 0 1.59 0 mirMAP -0.15 0.0069 NA
83 hsa-miR-148a-3p CEP55 -0.75 0 2.87 0 MirTarget -0.76 0 NA
84 hsa-miR-148a-3p CHST1 -0.75 0 0.69 0.00199 MirTarget -0.73 0 NA
85 hsa-miR-148a-3p CHST3 -0.75 0 -0.2 0.3013 mirMAP -0.54 0 NA
86 hsa-miR-148a-3p CIITA -0.75 0 0.27 0.18011 mirMAP -0.26 5.0E-5 NA
87 hsa-miR-148a-3p CIT -0.75 0 0.47 0.00991 miRNATAP -0.15 0.0119 NA
88 hsa-miR-148a-3p CNIH4 -0.75 0 1.01 0 MirTarget -0.1 0.00643 NA
89 hsa-miR-148a-5p CNIH4 -0.77 0 1.01 0 mirMAP -0.11 0.00201 NA
90 hsa-miR-148a-3p CNN1 -0.75 0 0.41 0.09282 miRNATAP -0.5 0 NA
91 hsa-miR-148a-5p CNNM1 -0.77 0 0.34 0.46754 MirTarget -0.48 0.00081 NA
92 hsa-miR-148a-3p CNTN4 -0.75 0 -2.24 0 miRNATAP -0.27 0.00181 NA
93 hsa-miR-148a-3p COL4A1 -0.75 0 1.65 0 miRNATAP -0.51 0 NA
94 hsa-miR-148a-5p COL5A2 -0.77 0 0.52 0.00488 MirTarget -0.43 0 NA
95 hsa-miR-148a-3p CPD -0.75 0 0.6 0 MirTarget; miRNATAP -0.14 0.00104 NA
96 hsa-miR-148a-5p CPD -0.77 0 0.6 0 mirMAP -0.21 0 NA
97 hsa-miR-148a-3p CS -0.75 0 0.63 0 miRNATAP -0.15 0 NA
98 hsa-miR-148a-3p CSF1 -0.75 0 -0.59 0.00153 miRNATAP -0.26 2.0E-5 NA
99 hsa-miR-148a-5p CSNK1E -0.77 0 0.61 0 miRNATAP -0.25 0 NA
100 hsa-miR-148a-5p CSNK1G1 -0.77 0 0.52 0 mirMAP -0.11 1.0E-5 NA
101 hsa-miR-148a-3p CSPG4 -0.75 0 2.21 0 miRNATAP -0.47 0 NA
102 hsa-miR-148a-3p CTTNBP2NL -0.75 0 0.03 0.8194 MirTarget; miRNATAP -0.4 0 NA
103 hsa-miR-148a-5p CXorf23 -0.77 0 0.43 1.0E-5 miRNATAP -0.11 0.00024 NA
104 hsa-miR-148a-3p CYTH3 -0.75 0 0.61 0 MirTarget; miRNATAP -0.29 0 NA
105 hsa-miR-148a-5p CYTIP -0.77 0 -1.31 0 MirTarget -0.17 0.02059 NA
106 hsa-miR-148a-5p DDR1 -0.77 0 0.19 0.48336 miRNATAP -0.67 0 NA
107 hsa-miR-148a-3p DMPK -0.75 0 0.66 0 MirTarget -0.31 0 NA
108 hsa-miR-148a-3p DNAJC18 -0.75 0 0.38 0.00786 MirTarget -0.48 0 NA
109 hsa-miR-148a-3p DNER -0.75 0 1.29 0.00336 MirTarget; miRNATAP -1.04 0 NA
110 hsa-miR-148a-5p DNM3 -0.77 0 1.37 0 mirMAP -0.18 0.0012 NA
111 hsa-miR-148a-3p DNMT1 -0.75 0 1.07 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.22 0 25865490; 26111756; 25950085; 22167392 miR 148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1; We additionally show that miR-148a exerts this effect partially by attenuating expression of DNA methyltransferase 1 DNMT1;Moreover we found that miR-148a appeared to be a target of bufalin and miR-148a further regulated DNMT1 and p27 to control the stemness of OS cells;The Interplay Between miR 148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy; We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased; In ASPC-1 cancer cells the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells; Interestingly it was shown that the DNMT1 inhibition enhanced the expression of miR-148a; In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1;Studies have shown that microRNA-148a miR-148a was proved to be silenced while DNA methyltransferase 1 DNMT1 was over-expressed in gastric cancer; But the mechanism of aberrant expression of miR-148a and DNMT1 and their relationships in gastric cancer are still unknown; The aims of this study were to investigate the expression profile of miR-148a and DNMT1 and reveal whether they have any relationships; We used reverse-transcriptase quantitative real-time PCR methylation-specific PCR and Western blot to measure the level of miR-148a expression DNA methylation level and DNMT1 expression respectively; DNMT1 was over-expressed in primary tumors and cell lines while knockdown of DNMT1 using siRNA could decrease methylation level of miR-148a promoter and restore its expression; Furthermore ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation but no obvious change was found in apoptosis rate; These results suggest that miR-148a is inactivated by DNA hypermethylation of promoter region in gastric cancer which is mediated through DNMT1 over-expression; Additionally the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer and this may in turn result in over-expression of DNMT1 and promote DNA hypermethylation
112 hsa-miR-148a-5p DNMT3A -0.77 0 1.19 0 mirMAP -0.12 0.00479 NA
113 hsa-miR-148a-3p DNMT3B -0.75 0 1.62 0 miRNAWalker2 validate; miRTarBase -0.19 0.00195 20841507 Low ERG expressers presented with down-regulation of genes involved in the DNA-methylation machinery and up-regulation of miR-148a which targets DNMT3B
114 hsa-miR-148a-3p DOCK3 -0.75 0 1.9 0 miRNATAP -0.28 0.00024 NA
115 hsa-miR-148a-3p DOCK6 -0.75 0 0.92 0 MirTarget -0.24 0 NA
116 hsa-miR-148a-3p DOT1L -0.75 0 0.59 0 mirMAP -0.11 0.0049 NA
117 hsa-miR-148a-3p DPP3 -0.75 0 0.37 1.0E-5 miRNATAP -0.13 0 NA
118 hsa-miR-148a-3p DSTYK -0.75 0 1.01 0 miRNAWalker2 validate -0.2 0 NA
119 hsa-miR-148a-3p DTNA -0.75 0 1.85 0 miRNATAP -0.42 1.0E-5 NA
120 hsa-miR-148a-5p DTNA -0.77 0 1.85 0 mirMAP -0.47 0 NA
121 hsa-miR-148a-5p DTX3 -0.77 0 0.08 0.67413 mirMAP -0.35 0 NA
122 hsa-miR-148a-3p DYRK1B -0.75 0 0.43 0.00067 miRNATAP -0.23 0 NA
123 hsa-miR-148a-3p E2F3 -0.75 0 0.68 0 miRNATAP -0.29 0 NA
124 hsa-miR-148a-3p E2F7 -0.75 0 3.07 0 miRNATAP -0.24 0.00995 NA
125 hsa-miR-148a-5p ECT2 -0.77 0 2.35 0 miRNATAP -0.32 0 NA
126 hsa-miR-148a-5p EDA -0.77 0 -0.45 0.10078 mirMAP -0.5 0 NA
127 hsa-miR-148a-5p EDNRA -0.77 0 -0.02 0.89416 mirMAP -0.46 0 NA
128 hsa-miR-148a-5p EFHC1 -0.77 0 0.85 0 mirMAP -0.23 0 NA
129 hsa-miR-148a-3p EFNB2 -0.75 0 0.1 0.47703 MirTarget; miRNATAP -0.19 4.0E-5 NA
130 hsa-miR-148a-3p EGR3 -0.75 0 -2.49 0 MirTarget -0.21 0.01299 NA
131 hsa-miR-148a-3p ELFN2 -0.75 0 2.87 0 mirMAP -0.48 0.00248 NA
132 hsa-miR-148a-5p ELK3 -0.77 0 -0.37 0.06773 MirTarget -0.21 0.00069 NA
133 hsa-miR-148a-5p ENAH -0.77 0 1.4 0 mirMAP -0.28 0 NA
134 hsa-miR-148a-3p ENTPD1 -0.75 0 0.55 0 mirMAP -0.3 0 NA
135 hsa-miR-148a-5p ENTPD1 -0.77 0 0.55 0 mirMAP -0.24 0 NA
136 hsa-miR-148a-3p EPB41L1 -0.75 0 0.13 0.60566 MirTarget -0.3 0.00034 NA
137 hsa-miR-148a-5p EPCAM -0.77 0 -1.91 0.00205 miRNATAP -1.19 0 NA
138 hsa-miR-148a-5p EPHA3 -0.77 0 -1.76 0 mirMAP -0.54 0 NA
139 hsa-miR-148a-3p EPN2 -0.75 0 0.04 0.69334 MirTarget; miRNATAP -0.12 6.0E-5 NA
140 hsa-miR-148a-3p ERC2 -0.75 0 1.32 2.0E-5 MirTarget -0.31 0.00232 NA
141 hsa-miR-148a-3p ERMP1 -0.75 0 0.54 1.0E-5 MirTarget -0.26 0 NA
142 hsa-miR-148a-3p ETV5 -0.75 0 -0.15 0.35537 MirTarget; miRNATAP -0.3 0 NA
143 hsa-miR-148a-5p EXT1 -0.77 0 -0.12 0.33701 mirMAP -0.25 0 NA
144 hsa-miR-148a-3p F3 -0.75 0 -1.78 0 MirTarget -0.59 0 NA
145 hsa-miR-148a-5p FAM102B -0.77 0 -0.16 0.25601 MirTarget -0.29 0 NA
146 hsa-miR-148a-5p FAM117B -0.77 0 0.1 0.44264 MirTarget -0.28 0 NA
147 hsa-miR-148a-3p FAM160B2 -0.75 0 0.17 0.05405 mirMAP -0.16 0 NA
148 hsa-miR-148a-3p FAM53B -0.75 0 0.97 0 mirMAP -0.29 0 NA
149 hsa-miR-148a-3p FBXL19 -0.75 0 1.09 0 miRNATAP -0.38 0 NA
150 hsa-miR-148a-5p FBXO41 -0.77 0 0.4 0.10243 mirMAP -0.45 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 77 1402 2.025e-14 9.424e-11
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 84 1672 1.537e-13 2.766e-10
3 REGULATION OF CELL DIFFERENTIATION 78 1492 1.784e-13 2.766e-10
4 CELL DEVELOPMENT 74 1426 1.209e-12 1.406e-09
5 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 57 957 3.233e-12 3.008e-09
6 TISSUE DEVELOPMENT 75 1518 9.072e-12 7.036e-09
7 NEURON PROJECTION DEVELOPMENT 39 545 5.885e-11 3.912e-08
8 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 65 1275 7.55e-11 4.391e-08
9 NEURON DIFFERENTIATION 51 874 1.048e-10 5.419e-08
10 TISSUE MORPHOGENESIS 38 533 1.17e-10 5.442e-08
11 MORPHOGENESIS OF AN EPITHELIUM 32 400 2.08e-10 8.405e-08
12 REGULATION OF CELL DEVELOPMENT 49 836 2.168e-10 8.405e-08
13 NEURON PROJECTION MORPHOGENESIS 32 402 2.361e-10 8.451e-08
14 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 54 1021 1.02e-09 3.389e-07
15 REGULATION OF NEURON DIFFERENTIATION 37 554 1.273e-09 3.947e-07
16 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 44 750 1.891e-09 5.5e-07
17 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 2.125e-09 5.815e-07
18 CELLULAR COMPONENT MORPHOGENESIS 49 900 2.556e-09 6.25e-07
19 CELL PROJECTION ORGANIZATION 49 902 2.748e-09 6.25e-07
20 CARDIOVASCULAR SYSTEM DEVELOPMENT 45 788 2.821e-09 6.25e-07
21 CIRCULATORY SYSTEM DEVELOPMENT 45 788 2.821e-09 6.25e-07
22 NEURON PROJECTION GUIDANCE 21 205 3.88e-09 8.206e-07
23 EPITHELIUM DEVELOPMENT 50 945 4.463e-09 9.029e-07
24 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 56 1142 7.355e-09 1.426e-06
25 NEURON DEVELOPMENT 40 687 1.332e-08 2.478e-06
26 LOCOMOTION 54 1114 2.076e-08 3.716e-06
27 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 33 513 2.558e-08 4.408e-06
28 CELL PART MORPHOGENESIS 37 633 4.342e-08 7.216e-06
29 BIOLOGICAL ADHESION 50 1032 7.426e-08 1.192e-05
30 PROTEIN PHOSPHORYLATION 47 944 8.505e-08 1.319e-05
31 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 61 1395 9.722e-08 1.459e-05
32 TUBE DEVELOPMENT 33 552 1.432e-07 2.082e-05
33 TUBE MORPHOGENESIS 24 323 1.6e-07 2.19e-05
34 CENTRAL NERVOUS SYSTEM DEVELOPMENT 44 872 1.564e-07 2.19e-05
35 ACTIN FILAMENT BASED PROCESS 29 450 1.768e-07 2.351e-05
36 POSITIVE REGULATION OF CELL DIFFERENTIATION 42 823 2.254e-07 2.913e-05
37 POSITIVE REGULATION OF NEURON DIFFERENTIATION 23 306 2.368e-07 2.978e-05
38 REGULATION OF CELL ADHESION 35 629 3.31e-07 4.054e-05
39 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 337 3.485e-07 4.158e-05
40 BLOOD VESSEL MORPHOGENESIS 25 364 3.918e-07 4.558e-05
41 POSITIVE REGULATION OF CELL DEVELOPMENT 29 472 4.77e-07 5.414e-05
42 CELL MOTILITY 41 835 8.589e-07 9.294e-05
43 LOCALIZATION OF CELL 41 835 8.589e-07 9.294e-05
44 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 27 437 1.071e-06 0.0001133
45 VASCULATURE DEVELOPMENT 28 469 1.328e-06 0.0001373
46 ANGIOGENESIS 21 293 1.708e-06 0.0001728
47 REGULATION OF NEURON PROJECTION DEVELOPMENT 25 408 3.12e-06 0.0003024
48 EXTRACELLULAR STRUCTURE ORGANIZATION 21 304 3.062e-06 0.0003024
49 REGULATION OF CELL MORPHOGENESIS 30 552 3.765e-06 0.0003576
50 REGULATION OF EPITHELIAL CELL PROLIFERATION 20 285 4.149e-06 0.0003861
51 HEAD DEVELOPMENT 35 709 5.012e-06 0.0004573
52 NEURON RECOGNITION 7 33 5.41e-06 0.000484
53 ORGAN MORPHOGENESIS 39 841 6.27e-06 0.0005505
54 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 34 689 6.922e-06 0.0005964
55 MUSCLE STRUCTURE DEVELOPMENT 25 432 8.451e-06 0.000715
56 REGULATION OF CELLULAR COMPONENT MOVEMENT 36 771 1.245e-05 0.001035
57 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 62 1656 1.317e-05 0.001075
58 SYNAPSE ORGANIZATION 13 145 1.588e-05 0.001274
59 AGING 18 264 1.846e-05 0.001456
60 PHOSPHORYLATION 49 1228 2.372e-05 0.00184
61 NEURON MIGRATION 11 110 2.577e-05 0.001966
62 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 12 131 2.706e-05 0.002031
63 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 21 352 2.847e-05 0.002079
64 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 10 92 2.904e-05 0.002079
65 UROGENITAL SYSTEM DEVELOPMENT 19 299 2.899e-05 0.002079
66 HEART DEVELOPMENT 25 466 3.021e-05 0.00213
67 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 9 75 3.292e-05 0.002286
68 REGULATION OF CELL PROJECTION ORGANIZATION 28 558 3.377e-05 0.002311
69 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 64 1784 3.504e-05 0.002363
70 REGULATION OF CELL PROLIFERATION 56 1496 3.641e-05 0.002421
71 AXONAL FASCICULATION 5 20 5.389e-05 0.003531
72 EMBRYO DEVELOPMENT 38 894 5.572e-05 0.003601
73 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 68 1977 7.151e-05 0.004558
74 INTRACELLULAR SIGNAL TRANSDUCTION 57 1572 7.408e-05 0.004621
75 REGULATION OF AXONOGENESIS 13 168 7.449e-05 0.004621
76 TAXIS 24 464 7.695e-05 0.004653
77 REGULATION OF CALCIUM ION IMPORT 10 103 7.701e-05 0.004653
78 TISSUE MIGRATION 9 84 8.136e-05 0.004853
79 CONNECTIVE TISSUE DEVELOPMENT 14 194 8.477e-05 0.004993
80 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 40 983 9.13e-05 0.00531
81 REGULATION OF SEQUESTERING OF CALCIUM ION 10 107 0.0001063 0.005958
82 AMINOGLYCAN BIOSYNTHETIC PROCESS 10 107 0.0001063 0.005958
83 NEGATIVE REGULATION OF CELL ADHESION 15 223 0.0001057 0.005958
84 MUCOPOLYSACCHARIDE METABOLIC PROCESS 10 108 0.0001149 0.006365
85 NEGATIVE REGULATION OF GENE EXPRESSION 54 1493 0.0001243 0.006803
86 REGULATION OF CELL GROWTH 21 391 0.0001276 0.006903
87 REGULATION OF OSSIFICATION 13 178 0.0001338 0.007154
88 CELL CELL SIGNALING 33 767 0.0001384 0.007318
89 SKIN EPIDERMIS DEVELOPMENT 8 71 0.0001415 0.007396
90 SYNAPTIC SIGNALING 22 424 0.0001454 0.007518
91 CYTOSKELETON ORGANIZATION 35 838 0.0001544 0.007896
92 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 5 25 0.000169 0.008546
93 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 14 208 0.0001771 0.00886
94 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 13 184 0.000186 0.009209
95 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 10 115 0.0001936 0.009431
96 ACTION POTENTIAL 9 94 0.0001946 0.009431
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN KINASE ACTIVITY 32 640 9.966e-06 0.004629
2 SH3 DOMAIN BINDING 12 116 7.842e-06 0.004629
3 CYTOSKELETAL PROTEIN BINDING 37 819 1.935e-05 0.005993
4 PROTEIN DOMAIN SPECIFIC BINDING 30 624 3.932e-05 0.009132
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 58 1151 1.406e-09 8.214e-07
2 ANCHORING JUNCTION 29 489 9.806e-07 0.0002863
3 CONTRACTILE FIBER 17 211 3.515e-06 0.0006843
4 CYTOSKELETON 72 1967 5.216e-06 0.0007526
5 CELL SUBSTRATE JUNCTION 24 398 6.444e-06 0.0007526
6 I BAND 12 121 1.211e-05 0.001179
7 CELL PROJECTION 65 1786 1.935e-05 0.001614
8 NEURON PROJECTION 40 942 3.612e-05 0.002344
9 CELL CELL JUNCTION 22 383 3.28e-05 0.002344
10 AXON 23 418 4.253e-05 0.002484
11 CELL SURFACE 34 757 4.761e-05 0.002528
12 NEURON PART 47 1265 0.0001916 0.009324

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 TGF_beta_signaling_pathway_hsa04350 6 84 0.009577 0.1589
2 Ferroptosis_hsa04216 4 40 0.01054 0.1589
3 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 8 139 0.01061 0.1589
4 Ras_signaling_pathway_hsa04014 11 232 0.01222 0.1589
5 Hedgehog_signaling_pathway_hsa04340 4 47 0.01829 0.1618
6 Hippo_signaling_pathway_hsa04390 8 154 0.01867 0.1618
7 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.02398 0.1782
8 cGMP_PKG_signaling_pathway_hsa04022 7 163 0.06338 0.317
9 HIF_1_signaling_pathway_hsa04066 5 100 0.06514 0.317
10 cAMP_signaling_pathway_hsa04024 8 198 0.06554 0.317
11 Focal_adhesion_hsa04510 8 199 0.06707 0.317
12 Cell_adhesion_molecules_.CAMs._hsa04514 6 145 0.09403 0.347
13 Wnt_signaling_pathway_hsa04310 6 146 0.09639 0.347
14 Calcium_signaling_pathway_hsa04020 7 182 0.09949 0.347
15 ECM_receptor_interaction_hsa04512 4 82 0.101 0.347
16 MAPK_signaling_pathway_hsa04010 10 295 0.1068 0.347
17 Endocytosis_hsa04144 8 244 0.1583 0.4476
18 Tight_junction_hsa04530 6 170 0.1618 0.4476
19 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.1636 0.4476
20 Adherens_junction_hsa04520 3 72 0.2027 0.5142
21 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.2077 0.5142
22 PI3K_Akt_signaling_pathway_hsa04151 10 352 0.2302 0.544
23 ABC_transporters_hsa02010 2 45 0.253 0.5719
24 Notch_signaling_pathway_hsa04330 2 48 0.277 0.5798
25 Cell_cycle_hsa04110 4 124 0.2787 0.5798
26 FoxO_signaling_pathway_hsa04068 4 132 0.3175 0.635
27 Mitophagy_animal_hsa04137 2 65 0.4101 0.771
28 Phagosome_hsa04145 4 152 0.4151 0.771
29 Cellular_senescence_hsa04218 4 160 0.4535 0.813
30 Sphingolipid_signaling_pathway_hsa04071 3 118 0.469 0.813
31 Autophagy_animal_hsa04140 3 128 0.5231 0.8221
32 ErbB_signaling_pathway_hsa04012 2 85 0.5497 0.8221
33 Gap_junction_hsa04540 2 88 0.5686 0.8221
34 Apelin_signaling_pathway_hsa04371 3 137 0.5691 0.8221
35 Rap1_signaling_pathway_hsa04015 4 206 0.6513 0.9154
36 TNF_signaling_pathway_hsa04668 2 108 0.6795 0.926
37 Cytokine_cytokine_receptor_interaction_hsa04060 5 270 0.6945 0.926
38 AMPK_signaling_pathway_hsa04152 2 121 0.7384 0.9391
39 Oocyte_meiosis_hsa04114 2 124 0.7506 0.9391
40 Apoptosis_hsa04210 2 138 0.8012 0.9391
41 mTOR_signaling_pathway_hsa04150 2 151 0.8399 0.9391
42 Jak_STAT_signaling_pathway_hsa04630 2 162 0.8671 0.9391
43 Necroptosis_hsa04217 2 164 0.8716 0.9391
44 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.9408 0.9592

Quest ID: b98726afd253dec32b18062adbba5404