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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p ABHD2 -0.31 0.3708 0.63 0.15716 miRanda; mirMAP -0.27 0.00546 NA
2 hsa-miR-125a-5p ABHD3 -0.31 0.3708 0.21 0.58467 PITA; miRanda -0.18 0.02803 NA
3 hsa-miR-141-3p ABL1 1.13 0.09667 -0.28 0.25357 MirTarget -0.12 0 NA
4 hsa-miR-19a-3p ABL1 -1.4 0.00391 -0.28 0.25357 mirMAP -0.11 0.00272 NA
5 hsa-miR-29a-3p ABL1 -0.39 0.22665 -0.28 0.25357 miRNAWalker2 validate; miRNATAP -0.21 0.00019 NA
6 hsa-miR-29a-5p ABL1 -0.6 0.06643 -0.28 0.25357 MirTarget -0.12 0.02372 NA
7 hsa-miR-29b-3p ABL1 -0.39 0.34358 -0.28 0.25357 miRNATAP -0.19 1.0E-5 NA
8 hsa-miR-29c-3p ABL1 -0.13 0.74361 -0.28 0.25357 miRNATAP -0.15 0.0004 NA
9 hsa-miR-30b-5p ABL1 -0.68 0.07316 -0.28 0.25357 MirTarget; miRNATAP -0.17 0.0002 NA
10 hsa-miR-30d-5p ABL1 -0.01 0.97473 -0.28 0.25357 MirTarget; miRNATAP -0.15 0.01552 NA
11 hsa-miR-423-5p ABL1 -0.67 0.05556 -0.28 0.25357 MirTarget -0.12 0.017 NA
12 hsa-miR-125a-5p ACPP -0.31 0.3708 0.84 0.23008 MirTarget; miRanda -0.61 6.0E-5 NA
13 hsa-miR-125a-5p ACTBL2 -0.31 0.3708 1.45 0.14365 miRanda -0.65 0.00258 NA
14 hsa-miR-125a-5p ACTG2 -0.31 0.3708 0.67 0.55281 miRanda -0.66 0.00735 NA
15 hsa-miR-125a-5p ACTL6A -0.31 0.3708 0.27 0.19205 miRanda -0.18 2.0E-5 NA
16 hsa-miR-125a-5p ACTN4 -0.31 0.3708 0.21 0.5222 mirMAP -0.22 0.0019 NA
17 hsa-miR-125a-5p ADAM9 -0.31 0.3708 0.41 0.38674 PITA; miRanda -0.25 0.01649 NA
18 hsa-miR-125a-5p ADAMTS14 -0.31 0.3708 -0.08 0.91758 miRanda; mirMAP -0.68 2.0E-5 NA
19 hsa-miR-125a-5p ADAMTS9 -0.31 0.3708 -0.6 0.25854 miRanda -0.26 0.02448 NA
20 hsa-miR-125a-5p ADAP1 -0.31 0.3708 1.46 0.03319 mirMAP -0.78 0 NA
21 hsa-miR-125a-5p ADH5 -0.31 0.3708 0.05 0.76619 miRanda -0.11 0.00468 NA
22 hsa-miR-125a-5p ADM2 -0.31 0.3708 0.38 0.58067 mirMAP -0.82 0 NA
23 hsa-miR-125a-5p AEN -0.31 0.3708 0.28 0.32652 miRanda -0.18 0.00325 NA
24 hsa-miR-125a-5p AGTRAP -0.31 0.3708 -0.09 0.79335 miRNAWalker2 validate; miRanda -0.2 0.00471 NA
25 hsa-miR-125a-5p AIFM1 -0.31 0.3708 0.08 0.68492 miRanda -0.11 0.00731 NA
26 hsa-miR-125a-5p AKAP13 -0.31 0.3708 -0.44 0.16463 miRanda -0.23 0.00085 NA
27 hsa-miR-125a-5p ALDH1A3 -0.31 0.3708 0.26 0.72786 miRanda -0.38 0.02042 NA
28 hsa-miR-125a-5p ALPK1 -0.31 0.3708 -0.37 0.36057 miRanda -0.52 0 NA
29 hsa-miR-26b-5p ANAPC1 -1.22 0.00085 0.14 0.57801 miRNAWalker2 validate -0.16 0.00096 NA
30 hsa-miR-100-5p ANAPC11 1.03 0.03044 0.33 0.27929 miRNAWalker2 validate -0.29 0 NA
31 hsa-miR-766-3p ANAPC11 -1.21 0.00153 0.33 0.27929 MirTarget -0.22 0.00013 NA
32 hsa-miR-542-3p ANAPC2 -0.89 0.02064 -0.2 0.38656 miRanda -0.14 0.00174 NA
33 hsa-miR-30a-5p ANAPC5 -0.59 0.17531 -0.12 0.49214 miRNAWalker2 validate -0.11 8.0E-5 NA
34 hsa-miR-30c-2-3p ANAPC7 -0.62 0.13013 -0.02 0.91567 MirTarget -0.12 0.0001 NA
35 hsa-miR-125a-5p ANKS6 -0.31 0.3708 0.39 0.20456 MirTarget -0.17 0.00994 NA
36 hsa-miR-125a-5p ANO6 -0.31 0.3708 0.05 0.90255 miRanda -0.4 0 NA
37 hsa-miR-125a-5p ANPEP -0.31 0.3708 -0.43 0.66538 PITA; miRanda; miRNATAP -0.59 0.00702 NA
38 hsa-miR-125a-5p ANTXR2 -0.31 0.3708 0.45 0.35344 PITA -0.51 0 NA
39 hsa-miR-125a-5p ANXA11 -0.31 0.3708 0.21 0.52584 mirMAP -0.38 0 NA
40 hsa-miR-125a-5p APOD -0.31 0.3708 0.71 0.376 miRanda -0.44 0.01111 NA
41 hsa-miR-125a-5p ARHGAP11B -0.31 0.3708 0.43 0.4759 miRanda -0.3 0.02232 NA
42 hsa-miR-125a-5p ARHGAP27 -0.31 0.3708 0.33 0.47834 miRanda -0.4 0.0001 NA
43 hsa-miR-125a-5p ARHGEF2 -0.31 0.3708 0.01 0.98121 miRanda -0.29 2.0E-5 NA
44 hsa-miR-125a-5p ARMC7 -0.31 0.3708 0.14 0.58061 MirTarget; miRanda -0.14 0.00867 NA
45 hsa-miR-125a-5p ARPC5 -0.31 0.3708 -0.13 0.53299 miRNAWalker2 validate -0.11 0.01232 NA
46 hsa-miR-125a-5p ARSD -0.31 0.3708 0.54 0.1225 miRanda -0.2 0.00707 NA
47 hsa-miR-125a-5p ARSI -0.31 0.3708 -0.05 0.95343 MirTarget; miRanda -0.58 0.0005 NA
48 hsa-miR-125a-5p ASPH -0.31 0.3708 0.98 0.03201 miRanda -0.37 0.00021 NA
49 hsa-miR-125a-5p ATL2 -0.31 0.3708 -0 0.9982 miRNAWalker2 validate; miRanda -0.11 0.03608 NA
50 hsa-miR-18a-5p ATM -1.18 0.00436 -0.78 0.04275 miRNAWalker2 validate; miRTarBase; MirTarget -0.15 0.03076 23437304; 25963391; 23857602; 23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
51 hsa-miR-455-5p ATM -0.23 0.54044 -0.78 0.04275 miRanda -0.3 7.0E-5 NA
52 hsa-miR-301a-3p ATR -0.76 0.09613 -0.04 0.82153 mirMAP -0.1 0.00132 NA
53 hsa-miR-125a-5p B2M -0.31 0.3708 -0.36 0.22342 miRanda -0.2 0.0024 NA
54 hsa-miR-125a-5p B3GALNT2 -0.31 0.3708 0.28 0.24769 MirTarget; miRanda; miRNATAP -0.13 0.01209 NA
55 hsa-miR-125a-5p B3GNT3 -0.31 0.3708 4.44 0 MirTarget -0.81 1.0E-5 NA
56 hsa-miR-125a-5p B3GNT7 -0.31 0.3708 0.91 0.22431 mirMAP -0.73 1.0E-5 NA
57 hsa-miR-125a-5p B4GALT1 -0.31 0.3708 -0.2 0.59693 miRanda -0.47 0 NA
58 hsa-miR-125a-5p BAK1 -0.31 0.3708 0.35 0.26822 miRNAWalker2 validate; PITA; miRanda; miRNATAP -0.39 0 NA
59 hsa-miR-125a-5p BATF2 -0.31 0.3708 0 0.99425 miRanda -0.21 0.04307 NA
60 hsa-miR-125a-5p BAZ1A -0.31 0.3708 -0.22 0.53161 miRanda -0.33 1.0E-5 NA
61 hsa-miR-125a-5p BCAT1 -0.31 0.3708 -0.37 0.61191 MirTarget -0.43 0.00705 NA
62 hsa-miR-125a-5p BCKDK -0.31 0.3708 -0.01 0.94665 miRanda -0.15 0.00057 NA
63 hsa-miR-125a-5p BCL2L12 -0.31 0.3708 -0.07 0.87268 miRanda; miRNATAP -0.51 0 NA
64 hsa-miR-125a-5p BCL2L14 -0.31 0.3708 1.55 0.10771 MirTarget; PITA; miRanda -1.31 0 NA
65 hsa-miR-125a-5p BIK -0.31 0.3708 0.91 0.17202 miRanda -0.48 0.00101 NA
66 hsa-miR-125a-5p BLZF1 -0.31 0.3708 0.7 0.01024 miRanda -0.15 0.01388 NA
67 hsa-miR-125a-5p BMP1 -0.31 0.3708 -0.01 0.9761 mirMAP -0.19 0.03832 NA
68 hsa-miR-125a-5p BMPR1B -0.31 0.3708 0.22 0.768 MirTarget; miRNATAP -0.92 0 NA
69 hsa-miR-125a-5p BRCC3 -0.31 0.3708 0.28 0.1857 miRanda -0.1 0.02579 NA
70 hsa-miR-125a-5p BTN2A2 -0.31 0.3708 -1.12 0.00207 miRanda -0.25 0.00172 NA
71 hsa-miR-139-5p BUB1 -1.64 0.00654 0.75 0.2317 miRanda -0.35 0 NA
72 hsa-miR-324-5p BUB1 -0.99 0.00957 0.75 0.2317 MirTarget -0.27 0.02734 NA
73 hsa-miR-495-3p BUB1 -0.82 0.09306 0.75 0.2317 MirTarget -0.39 3.0E-5 NA
74 hsa-miR-543 BUB1 -1.03 0.07135 0.75 0.2317 miRanda -0.31 9.0E-5 NA
75 hsa-miR-543 BUB1B -1.03 0.07135 0.73 0.18404 miRanda -0.21 0.00376 NA
76 hsa-miR-125a-5p C1RL -0.31 0.3708 -0.35 0.31475 miRanda -0.34 0 NA
77 hsa-miR-125a-5p C2 -0.31 0.3708 -0.78 0.18449 miRanda -0.61 0 NA
78 hsa-miR-125a-5p CANT1 -0.31 0.3708 0.64 0.0479 mirMAP -0.36 0 NA
79 hsa-miR-125a-5p CASP10 -0.31 0.3708 -0.18 0.62889 mirMAP -0.33 2.0E-5 NA
80 hsa-miR-125a-5p CASP6 -0.31 0.3708 0.22 0.45531 miRanda -0.34 0 NA
81 hsa-miR-125a-5p CBLB -0.31 0.3708 -0.33 0.19169 miRanda -0.19 0.00051 NA
82 hsa-let-7b-5p CCNA1 0.13 0.6518 -0.49 0.55046 miRNAWalker2 validate -0.8 0.00011 NA
83 hsa-miR-30a-5p CCNA1 -0.59 0.17531 -0.49 0.55046 MirTarget -0.31 0.02677 NA
84 hsa-miR-129-5p CCNA2 1.01 0.36712 0.67 0.16545 miRanda -0.18 0 NA
85 hsa-miR-132-3p CCNA2 -0.19 0.63856 0.67 0.16545 miRNAWalker2 validate -0.36 5.0E-5 NA
86 hsa-miR-212-3p CCNA2 -0.37 0.45016 0.67 0.16545 miRNAWalker2 validate -0.21 0.004 NA
87 hsa-miR-218-5p CCNA2 -0.69 0.12531 0.67 0.16545 MirTarget -0.26 0.00083 NA
88 hsa-miR-29c-3p CCNA2 -0.13 0.74361 0.67 0.16545 MirTarget -0.28 0.00167 NA
89 hsa-miR-301a-3p CCNA2 -0.76 0.09613 0.67 0.16545 miRNATAP -0.2 0.00997 NA
90 hsa-miR-374a-5p CCNA2 -0.77 0.02145 0.67 0.16545 mirMAP -0.21 0.04649 NA
91 hsa-miR-98-5p CCNA2 -0.22 0.42277 0.67 0.16545 miRNAWalker2 validate -0.32 0.01832 NA
92 hsa-miR-132-3p CCNB1 -0.19 0.63856 1.05 0.01857 miRNAWalker2 validate -0.26 0.00151 NA
93 hsa-miR-139-5p CCNB1 -1.64 0.00654 1.05 0.01857 miRanda -0.24 0 NA
94 hsa-miR-212-3p CCNB1 -0.37 0.45016 1.05 0.01857 miRNAWalker2 validate -0.18 0.00662 NA
95 hsa-miR-496 CCNB1 -0.26 0.66888 1.05 0.01857 miRanda -0.13 0.0144 NA
96 hsa-miR-543 CCNB1 -1.03 0.07135 1.05 0.01857 miRanda -0.14 0.01214 NA
97 hsa-miR-23b-3p CCNB2 0.01 0.97527 0.8 0.25181 miRNAWalker2 validate -0.65 0.00469 NA
98 hsa-miR-135a-5p CCND1 -0.2 0.83089 1.04 0.01709 mirMAP -0.1 0.00282 NA
99 hsa-miR-142-3p CCND1 -2.4 4.0E-5 1.04 0.01709 miRanda -0.11 0.04224 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil
100 hsa-miR-150-5p CCND1 -1.91 0.02035 1.04 0.01709 mirMAP -0.1 0.00937 NA
101 hsa-miR-15a-5p CCND1 -0.74 0.01074 1.04 0.01709 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.36 0.00124 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR
102 hsa-miR-16-5p CCND1 -1.02 0.00033 1.04 0.01709 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.35 0.00208 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
103 hsa-miR-186-5p CCND1 -0.77 0.00203 1.04 0.01709 mirMAP -0.5 0.00012 NA
104 hsa-miR-195-5p CCND1 -0.69 0.07175 1.04 0.01709 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.23 0.00668 21350001; 26631043; 25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma
105 hsa-miR-20b-5p CCND1 -1.45 0.00948 1.04 0.01709 MirTarget; miRNATAP -0.15 0.00755 NA
106 hsa-miR-296-5p CCND1 -1.02 0.0303 1.04 0.01709 miRNAWalker2 validate -0.19 0.00651 20485139 Downregulation of miR-296 might inhibit growth of esophageal cancer cells in vitro and in vivo through regulation of cyclin D1 and p27
107 hsa-miR-29c-3p CCND1 -0.13 0.74361 1.04 0.01709 mirMAP -0.24 0.00236 NA
108 hsa-miR-330-3p CCND1 0.23 0.63792 1.04 0.01709 mirMAP -0.22 0.00098 NA
109 hsa-miR-338-3p CCND1 0.51 0.34448 1.04 0.01709 miRNAWalker2 validate; miRTarBase; miRanda -0.13 0.0237 NA
110 hsa-miR-33a-3p CCND1 -1.71 0.00034 1.04 0.01709 MirTarget -0.14 0.03887 NA
111 hsa-miR-340-5p CCND1 -0.87 0.0362 1.04 0.01709 mirMAP -0.26 0.00064 NA
112 hsa-miR-374a-5p CCND1 -0.77 0.02145 1.04 0.01709 MirTarget -0.36 0.0002 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression
113 hsa-miR-374b-5p CCND1 -0.94 0.0014 1.04 0.01709 miRNAWalker2 validate; MirTarget -0.35 0.00167 NA
114 hsa-miR-495-3p CCND1 -0.82 0.09306 1.04 0.01709 MirTarget -0.22 0.00064 NA
115 hsa-miR-497-5p CCND1 -0.81 0.02071 1.04 0.01709 MirTarget; miRNATAP -0.18 0.04981 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer
116 hsa-miR-590-3p CCND1 -0.92 0.03456 1.04 0.01709 mirMAP -0.23 0.00179 NA
117 hsa-miR-7-1-3p CCND1 -0.73 0.0834 1.04 0.01709 mirMAP -0.34 1.0E-5 NA
118 hsa-miR-769-3p CCND1 -0.42 0.40382 1.04 0.01709 mirMAP -0.2 0.0019 NA
119 hsa-miR-9-5p CCND1 -0.04 0.94649 1.04 0.01709 miRNAWalker2 validate -0.16 0.00122 NA
120 hsa-let-7b-3p CCND2 -0.41 0.16777 -0.32 0.53544 mirMAP -0.39 0.00252 NA
121 hsa-miR-10a-3p CCND2 -0.28 0.53841 -0.32 0.53544 mirMAP -0.3 0.00038 NA
122 hsa-miR-16-2-3p CCND2 -1.03 0.00735 -0.32 0.53544 mirMAP -0.21 0.03069 NA
123 hsa-miR-17-5p CCND2 -0.67 0.04231 -0.32 0.53544 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.37 0.00132 NA
124 hsa-miR-181a-2-3p CCND2 -0.83 0.04338 -0.32 0.53544 mirMAP -0.45 0 NA
125 hsa-miR-196a-5p CCND2 2.84 0.01406 -0.32 0.53544 miRNAWalker2 validate -0.14 2.0E-5 NA
126 hsa-miR-20a-5p CCND2 -0.39 0.26959 -0.32 0.53544 miRNAWalker2 validate; miRTarBase; miRNATAP -0.33 0.00206 NA
127 hsa-miR-21-3p CCND2 -0.44 0.44935 -0.32 0.53544 mirMAP -0.26 6.0E-5 NA
128 hsa-miR-224-3p CCND2 -0.91 0.10932 -0.32 0.53544 mirMAP -0.25 0.00011 NA
129 hsa-miR-2355-3p CCND2 -0.91 0.0288 -0.32 0.53544 miRNATAP -0.36 7.0E-5 NA
130 hsa-miR-28-5p CCND2 -0.53 0.03042 -0.32 0.53544 miRanda -0.49 0.00234 NA
131 hsa-miR-29a-3p CCND2 -0.39 0.22665 -0.32 0.53544 MirTarget; miRNATAP -0.24 0.04604 22330340; 24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC
132 hsa-miR-30a-3p CCND2 -0.7 0.13951 -0.32 0.53544 mirMAP -0.23 0.00501 NA
133 hsa-miR-708-3p CCND2 -0.29 0.54382 -0.32 0.53544 mirMAP -0.17 0.03697 NA
134 hsa-miR-93-5p CCND2 -0.47 0.13146 -0.32 0.53544 miRNATAP -0.35 0.00536 NA
135 hsa-let-7b-5p CCND3 0.13 0.6518 0.09 0.75989 miRNAWalker2 validate -0.25 0.0004 NA
136 hsa-miR-26a-5p CCNE1 -0.6 0.02459 0.83 0.08087 miRNAWalker2 validate; miRTarBase; miRNATAP -0.38 0.00465 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen
137 hsa-miR-874-3p CCNE1 -0.13 0.77247 0.83 0.08087 MirTarget -0.16 0.03199 NA
138 hsa-miR-30b-5p CCNE2 -0.68 0.07316 0.43 0.30154 miRNAWalker2 validate; miRTarBase -0.16 0.04889 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2
139 hsa-miR-369-3p CCNE2 -0.83 0.17364 0.43 0.30154 PITA -0.14 0.00391 NA
140 hsa-miR-23a-3p CCNH -0.22 0.39943 -0.01 0.96731 MirTarget -0.14 0.00863 NA
141 hsa-miR-23b-3p CCNH 0.01 0.97527 -0.01 0.96731 MirTarget -0.12 0.04997 NA
142 hsa-miR-125a-5p CCT2 -0.31 0.3708 0.18 0.4333 miRanda -0.12 0.01365 NA
143 hsa-miR-125a-5p CD248 -0.31 0.3708 0.06 0.91415 PITA; miRanda; miRNATAP -0.3 0.01514 NA
144 hsa-miR-125a-5p CD276 -0.31 0.3708 -0.03 0.92101 miRanda -0.27 0.00013 NA
145 hsa-miR-125a-5p CD300LF -0.31 0.3708 -1.89 0.00608 miRNATAP -0.3 0.0488 NA
146 hsa-miR-125a-5p CDA -0.31 0.3708 1.34 0.11216 miRanda -0.54 0.00357 NA
147 hsa-let-7a-3p CDC14A -0.95 0.00672 -0.8 0.05646 mirMAP -0.24 0.00658 NA
148 hsa-miR-141-3p CDC14A 1.13 0.09667 -0.8 0.05646 TargetScan; miRNATAP -0.23 0 NA
149 hsa-miR-192-5p CDC14A 2.1 0.00233 -0.8 0.05646 miRNAWalker2 validate -0.15 0.00099 NA
150 hsa-miR-194-5p CDC14A 2.55 0.00024 -0.8 0.05646 miRNATAP -0.14 0.00173 NA
NumGOOverlapSizeP ValueAdj. P Value
1 MITOTIC CELL CYCLE 89 766 7.005e-34 3.259e-30
2 CELL CYCLE 116 1316 7.187e-33 1.672e-29
3 CELL CYCLE PROCESS 104 1081 1.603e-32 2.486e-29
4 REGULATION OF CELL CYCLE 93 949 1.371e-29 1.595e-26
5 REGULATION OF CELL CYCLE PHASE TRANSITION 53 321 1.27e-27 1.181e-24
6 REGULATION OF MITOTIC CELL CYCLE 61 468 6.407e-26 4.969e-23
7 CELL CYCLE PHASE TRANSITION 46 255 8.788e-26 5.842e-23
8 CELL CYCLE G1 S PHASE TRANSITION 32 111 5.777e-25 2.987e-22
9 G1 S TRANSITION OF MITOTIC CELL CYCLE 32 111 5.777e-25 2.987e-22
10 REGULATION OF CELL CYCLE PROCESS 64 558 4.738e-24 2.205e-21
11 CELL CYCLE CHECKPOINT 38 194 8.294e-23 3.508e-20
12 NEGATIVE REGULATION OF CELL CYCLE 52 433 1.437e-20 5.573e-18
13 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 36 199 1.892e-20 6.771e-18
14 CELL DIVISION 53 460 4.005e-20 1.331e-17
15 MITOTIC CELL CYCLE CHECKPOINT 30 139 1.613e-19 5.003e-17
16 NEGATIVE REGULATION OF CELL CYCLE PROCESS 36 214 2.332e-19 6.783e-17
17 REGULATION OF TRANSFERASE ACTIVITY 76 946 5.925e-19 1.622e-16
18 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 30 146 7.1e-19 1.835e-16
19 DNA INTEGRITY CHECKPOINT 28 146 7.189e-17 1.76e-14
20 POSITIVE REGULATION OF CELL CYCLE 40 332 4.179e-16 9.722e-14
21 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 23 103 1.31e-15 2.903e-13
22 MITOTIC NUCLEAR DIVISION 41 361 1.414e-15 2.991e-13
23 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 20 77 4.154e-15 8.404e-13
24 REGULATION OF LIGASE ACTIVITY 24 130 2.943e-14 5.706e-12
25 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 21 98 5.501e-14 1.024e-11
26 POSITIVE REGULATION OF LIGASE ACTIVITY 22 110 6.258e-14 1.096e-11
27 REGULATION OF PROTEIN MODIFICATION PROCESS 97 1710 6.362e-14 1.096e-11
28 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 38 351 7.467e-14 1.241e-11
29 REGULATION OF PROTEIN CATABOLIC PROCESS 40 393 1.244e-13 1.996e-11
30 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 24 139 1.384e-13 2.146e-11
31 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 28 196 1.751e-13 2.628e-11
32 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 51 616 1.82e-13 2.647e-11
33 ORGANELLE FISSION 45 496 2.179e-13 2.982e-11
34 POSITIVE REGULATION OF PROTEOLYSIS 38 363 2.164e-13 2.982e-11
35 G1 DNA DAMAGE CHECKPOINT 18 73 2.652e-13 3.526e-11
36 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 33 280 3.18e-13 3.999e-11
37 POSITIVE REGULATION OF CELL CYCLE PROCESS 31 247 3.109e-13 3.999e-11
38 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 71 1087 3.785e-13 4.634e-11
39 REGULATION OF CELL PROLIFERATION 87 1496 4.171e-13 4.976e-11
40 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 50 616 6.745e-13 7.846e-11
41 MITOTIC DNA INTEGRITY CHECKPOINT 20 100 8.745e-13 9.925e-11
42 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 32 274 9.417e-13 1.043e-10
43 POSITIVE REGULATION OF CATALYTIC ACTIVITY 86 1518 2.41e-12 2.607e-10
44 NEGATIVE REGULATION OF CELL PROLIFERATION 50 643 3.329e-12 3.521e-10
45 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 23 147 3.803e-12 3.847e-10
46 PROTEASOMAL PROTEIN CATABOLIC PROCESS 31 271 3.727e-12 3.847e-10
47 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 19 96 3.978e-12 3.938e-10
48 REGULATION OF CELL DIVISION 31 272 4.108e-12 3.982e-10
49 POSITIVE REGULATION OF CELL CYCLE ARREST 18 85 4.375e-12 4.154e-10
50 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 19 97 4.83e-12 4.495e-10
51 POSITIVE REGULATION OF MOLECULAR FUNCTION 95 1791 6.105e-12 5.57e-10
52 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 69 1135 2.264e-11 2.026e-09
53 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 25 192 2.824e-11 2.479e-09
54 REGULATION OF CELL CYCLE ARREST 19 108 3.513e-11 3.027e-09
55 REGULATION OF PROTEOLYSIS 51 711 3.901e-11 3.301e-09
56 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 29 263 4.615e-11 3.835e-09
57 CELL CYCLE ARREST 22 154 7.077e-11 5.777e-09
58 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 81 1492 9.714e-11 7.793e-09
59 REGULATION OF SISTER CHROMATID SEGREGATION 15 67 1.165e-10 9.187e-09
60 REGULATION OF ORGANELLE ORGANIZATION 68 1178 3.025e-10 2.346e-08
61 REGULATION OF CATABOLIC PROCESS 50 731 3.234e-10 2.467e-08
62 REGULATION OF CHROMOSOME SEGREGATION 16 85 4.414e-10 3.312e-08
63 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 13 53 6.038e-10 4.39e-08
64 POSITIVE REGULATION OF CELL DEATH 44 605 6.017e-10 4.39e-08
65 SISTER CHROMATID SEGREGATION 22 176 9.714e-10 6.954e-08
66 TISSUE DEVELOPMENT 79 1518 1.237e-09 8.723e-08
67 REGULATION OF NUCLEAR DIVISION 21 163 1.34e-09 9.307e-08
68 REGULATION OF FIBROBLAST PROLIFERATION 15 81 1.971e-09 1.349e-07
69 CELLULAR RESPONSE TO STRESS 80 1565 2.176e-09 1.468e-07
70 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 18 127 4.36e-09 2.898e-07
71 CELL PROLIFERATION 45 672 5.034e-09 3.266e-07
72 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 47 720 5.054e-09 3.266e-07
73 REGULATION OF KINASE ACTIVITY 49 776 6.875e-09 4.323e-07
74 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 58 1004 6.854e-09 4.323e-07
75 POSITIVE REGULATION OF RESPONSE TO STIMULUS 91 1929 7.768e-09 4.819e-07
76 REGULATION OF CELL DEATH 75 1472 8.643e-09 5.292e-07
77 RESPONSE TO OXYGEN LEVELS 28 311 1.004e-08 6.07e-07
78 INTRACELLULAR SIGNAL TRANSDUCTION 78 1572 1.322e-08 7.885e-07
79 REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE 9 27 1.416e-08 8.339e-07
80 CELL DEATH 57 1001 1.554e-08 8.956e-07
81 REGULATION OF CHROMOSOME ORGANIZATION 26 278 1.559e-08 8.956e-07
82 CELL CYCLE G2 M PHASE TRANSITION 18 138 1.665e-08 9.447e-07
83 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 87 1848 1.957e-08 1.097e-06
84 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 50 829 2.106e-08 1.167e-06
85 NUCLEAR CHROMOSOME SEGREGATION 23 228 2.608e-08 1.428e-06
86 RESPONSE TO GROWTH FACTOR 35 475 2.646e-08 1.432e-06
87 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 13 71 2.734e-08 1.462e-06
88 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 85 1805 2.907e-08 1.52e-06
89 DNA REPLICATION INITIATION 9 29 2.89e-08 1.52e-06
90 PROTEIN PHOSPHORYLATION 54 944 3.298e-08 1.705e-06
91 RESPONSE TO ABIOTIC STIMULUS 57 1024 3.418e-08 1.747e-06
92 REGULATION OF CELLULAR PROTEIN LOCALIZATION 38 552 4.033e-08 2.04e-06
93 IMMUNE SYSTEM DEVELOPMENT 39 582 5.452e-08 2.728e-06
94 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 29 360 6.401e-08 3.169e-06
95 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 34 470 6.558e-08 3.212e-06
96 EPITHELIUM DEVELOPMENT 53 945 8.458e-08 4.1e-06
97 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 19 171 9.278e-08 4.451e-06
98 G2 DNA DAMAGE CHECKPOINT 9 33 1.015e-07 4.821e-06
99 DNA REPLICATION 21 208 1.039e-07 4.883e-06
100 APOPTOTIC SIGNALING PATHWAY 25 289 1.354e-07 6.302e-06
101 PROTEIN CATABOLIC PROCESS 38 579 1.384e-07 6.323e-06
102 POSITIVE REGULATION OF CATABOLIC PROCESS 30 395 1.386e-07 6.323e-06
103 REGULATION OF IMMUNE SYSTEM PROCESS 69 1403 1.439e-07 6.5e-06
104 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 82 1784 1.507e-07 6.743e-06
105 CHROMOSOME SEGREGATION 24 272 1.672e-07 7.408e-06
106 DNA METABOLIC PROCESS 45 758 1.751e-07 7.686e-06
107 POSITIVE REGULATION OF CELL COMMUNICATION 73 1532 2.059e-07 8.956e-06
108 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 9 36 2.314e-07 9.971e-06
109 REGULATION OF PROTEIN LOCALIZATION 52 950 2.414e-07 1.031e-05
110 PROTEIN K11 LINKED UBIQUITINATION 8 27 2.602e-07 1.101e-05
111 DIGESTIVE SYSTEM DEVELOPMENT 17 148 2.723e-07 1.142e-05
112 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 54 1008 2.761e-07 1.147e-05
113 NEGATIVE REGULATION OF CELL DIVISION 11 60 3.188e-07 1.313e-05
114 PROTEOLYSIS 61 1208 3.404e-07 1.39e-05
115 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 16 134 3.584e-07 1.437e-05
116 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 8 28 3.561e-07 1.437e-05
117 RESPONSE TO OXYGEN CONTAINING COMPOUND 67 1381 3.662e-07 1.456e-05
118 INTRINSIC APOPTOTIC SIGNALING PATHWAY 17 152 4.002e-07 1.578e-05
119 REGULATION OF PHOSPHORUS METABOLIC PROCESS 75 1618 4.041e-07 1.58e-05
120 IMMUNE SYSTEM PROCESS 87 1984 4.567e-07 1.742e-05
121 NEGATIVE REGULATION OF MOLECULAR FUNCTION 56 1079 4.543e-07 1.742e-05
122 GLAND DEVELOPMENT 29 395 4.549e-07 1.742e-05
123 RESPONSE TO GAMMA RADIATION 10 50 4.701e-07 1.764e-05
124 CATABOLIC PROCESS 80 1773 4.664e-07 1.764e-05
125 MITOTIC SISTER CHROMATID SEGREGATION 13 91 5.648e-07 2.103e-05
126 POSITIVE REGULATION OF GENE EXPRESSION 78 1733 7.336e-07 2.709e-05
127 REGULATION OF DNA REPLICATION 17 161 9.078e-07 3.326e-05
128 SISTER CHROMATID COHESION 14 111 9.869e-07 3.587e-05
129 RESPONSE TO ENDOGENOUS STIMULUS 68 1450 1.005e-06 3.626e-05
130 RESPONSE TO IONIZING RADIATION 16 145 1.051e-06 3.763e-05
131 REGULATION OF CELL GROWTH 28 391 1.178e-06 4.164e-05
132 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 9 43 1.181e-06 4.164e-05
133 PHOSPHORYLATION 60 1228 1.268e-06 4.404e-05
134 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 40 684 1.267e-06 4.404e-05
135 REGULATION OF ORGAN MORPHOGENESIS 21 242 1.295e-06 4.463e-05
136 DNA DEPENDENT DNA REPLICATION 13 99 1.512e-06 5.172e-05
137 REGULATION OF MEMBRANE PERMEABILITY 11 70 1.597e-06 5.423e-05
138 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 8 34 1.816e-06 6.124e-05
139 NEGATIVE REGULATION OF NUCLEAR DIVISION 9 46 2.155e-06 7.214e-05
140 SPINDLE CHECKPOINT 7 25 2.286e-06 7.598e-05
141 RESPONSE TO ORGANIC CYCLIC COMPOUND 48 917 2.518e-06 8.309e-05
142 REGULATION OF APOPTOTIC SIGNALING PATHWAY 26 363 2.826e-06 9.259e-05
143 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 8 36 2.894e-06 9.415e-05
144 POSITIVE REGULATION OF CELL PROLIFERATION 44 814 2.966e-06 9.55e-05
145 PEPTIDYL AMINO ACID MODIFICATION 45 841 2.976e-06 9.55e-05
146 MACROMOLECULE CATABOLIC PROCESS 48 926 3.288e-06 0.0001048
147 POSITIVE REGULATION OF MITOTIC CELL CYCLE 14 123 3.419e-06 0.0001082
148 LEUKOCYTE ACTIVATION 28 414 3.568e-06 0.0001122
149 REGENERATION 16 161 4.205e-06 0.0001304
150 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 32 514 4.183e-06 0.0001304
151 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 9 50 4.473e-06 0.0001378
152 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 13 109 4.524e-06 0.0001382
153 RESPONSE TO UV 14 126 4.552e-06 0.0001382
154 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 51 1021 4.575e-06 0.0001382
155 CELL ACTIVATION 34 568 4.912e-06 0.0001475
156 REGULATION OF EPITHELIAL CELL PROLIFERATION 22 285 5.013e-06 0.0001495
157 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 12 95 5.759e-06 0.0001707
158 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 29 6.79e-06 0.000198
159 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 29 6.79e-06 0.000198
160 ORGAN MORPHOGENESIS 44 841 6.807e-06 0.000198
161 TUBE DEVELOPMENT 33 552 6.961e-06 0.0002012
162 REPLICATIVE SENESCENCE 5 12 7.5e-06 0.0002154
163 RESPONSE TO DRUG 28 431 7.622e-06 0.0002176
164 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 15 150 7.748e-06 0.0002198
165 REGULATION OF GROWTH 36 633 8.086e-06 0.000228
166 REGULATION OF DNA METABOLIC PROCESS 24 340 8.691e-06 0.0002436
167 LYMPHOCYTE ACTIVATION 24 342 9.588e-06 0.0002671
168 RESPONSE TO RADIATION 27 413 9.883e-06 0.0002737
169 NEGATIVE REGULATION OF DNA REPLICATION 9 55 1.013e-05 0.0002789
170 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 29 465 1.143e-05 0.0003129
171 RESPONSE TO LIPID 45 888 1.196e-05 0.0003254
172 CELLULAR RESPONSE TO RADIATION 14 137 1.209e-05 0.000327
173 CELLULAR CATABOLIC PROCESS 60 1322 1.265e-05 0.0003403
174 NEGATIVE REGULATION OF PHOSPHORYLATION 27 422 1.455e-05 0.000389
175 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 54 1152 1.465e-05 0.0003896
176 CHROMOSOME ORGANIZATION 49 1009 1.501e-05 0.0003946
177 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 33 573 1.5e-05 0.0003946
178 CELLULAR RESPONSE TO ABIOTIC STIMULUS 20 263 1.669e-05 0.0004362
179 PROTEIN POLYUBIQUITINATION 19 243 1.835e-05 0.0004769
180 POSITIVE REGULATION OF TRANSPORT 46 936 2.063e-05 0.0005333
181 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 34 2.094e-05 0.0005383
182 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I 11 91 2.149e-05 0.0005495
183 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 41 799 2.218e-05 0.0005639
184 MITOCHONDRIAL MEMBRANE ORGANIZATION 11 92 2.386e-05 0.0006033
185 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 17 207 2.686e-05 0.0006756
186 DIGESTIVE TRACT MORPHOGENESIS 8 48 2.753e-05 0.0006886
187 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 60 1360 2.917e-05 0.0007258
188 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 31 541 2.993e-05 0.0007369
189 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 31 541 2.993e-05 0.0007369
190 REGULATION OF INTRACELLULAR TRANSPORT 34 621 3.143e-05 0.0007696
191 POSITIVE REGULATION OF CHROMOSOME SEGREGATION 6 25 3.269e-05 0.0007964
192 REGULATION OF CELLULAR LOCALIZATION 57 1277 3.391e-05 0.0008217
193 REGULATION OF STEM CELL DIFFERENTIATION 12 113 3.429e-05 0.0008268
194 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 24 370 3.472e-05 0.0008328
195 NEGATIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 9 64 3.575e-05 0.0008402
196 TUBE MORPHOGENESIS 22 323 3.53e-05 0.0008402
197 CARDIOVASCULAR SYSTEM DEVELOPMENT 40 788 3.562e-05 0.0008402
198 CIRCULATORY SYSTEM DEVELOPMENT 40 788 3.562e-05 0.0008402
199 EPITHELIAL CELL DIFFERENTIATION 29 495 3.622e-05 0.0008468
200 POSITIVE REGULATION OF CELL DIVISION 13 132 3.647e-05 0.0008485
201 REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 5 16 3.798e-05 0.0008749
202 CELLULAR RESPONSE TO ANTIBIOTIC 5 16 3.798e-05 0.0008749
203 RESPONSE TO STEROID HORMONE 29 497 3.895e-05 0.0008927
204 REGULATION OF RESPONSE TO STRESS 63 1468 4.144e-05 0.0009453
205 CELLULAR RESPONSE TO UV 9 66 4.592e-05 0.001037
206 ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I 9 66 4.592e-05 0.001037
207 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 11 99 4.761e-05 0.001065
208 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 11 99 4.761e-05 0.001065
209 GLIOGENESIS 15 175 4.842e-05 0.001078
210 GLIAL CELL DIFFERENTIATION 13 136 4.99e-05 0.001106
211 CELLULAR RESPONSE TO IONIZING RADIATION 8 52 5.017e-05 0.001106
212 ORGAN REGENERATION 10 83 5.217e-05 0.001121
213 POSITIVE REGULATION OF NEURON DEATH 9 67 5.185e-05 0.001121
214 REGULATION OF HYDROLASE ACTIVITY 58 1327 5.189e-05 0.001121
215 RESPONSE TO ESTROGEN 17 218 5.177e-05 0.001121
216 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 17 218 5.177e-05 0.001121
217 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 11 100 5.227e-05 0.001121
218 NEGATIVE REGULATION OF CELL AGING 5 17 5.267e-05 0.001124
219 SKELETAL SYSTEM DEVELOPMENT 27 455 5.392e-05 0.001146
220 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 9 68 5.842e-05 0.001236
221 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 69 1672 5.907e-05 0.001244
222 REGULATION OF MICROTUBULE BASED PROCESS 18 243 6.155e-05 0.00129
223 REGULATION OF TRANSPORT 73 1804 6.608e-05 0.001379
224 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 24 387 7.052e-05 0.001465
225 POSITIVE REGULATION OF DNA REPLICATION 10 86 7.091e-05 0.001466
226 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 15 181 7.125e-05 0.001467
227 NEGATIVE REGULATION OF CELL COMMUNICATION 53 1192 7.183e-05 0.001472
228 LEUKOCYTE DIFFERENTIATION 20 292 7.339e-05 0.001491
229 CELLULAR COMPONENT DISASSEMBLY 29 515 7.331e-05 0.001491
230 NEGATIVE REGULATION OF CELL DEATH 42 872 7.487e-05 0.001515
231 CRANIAL SKELETAL SYSTEM DEVELOPMENT 8 55 7.588e-05 0.001528
232 ANGIOGENESIS 20 293 7.693e-05 0.001543
233 ENDODERM DEVELOPMENT 9 71 8.248e-05 0.001647
234 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 13 144 9.011e-05 0.001792
235 POSITIVE REGULATION OF DNA METABOLIC PROCESS 15 185 9.127e-05 0.001807
236 APOPTOTIC MITOCHONDRIAL CHANGES 8 57 9.846e-05 0.001941
237 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 23 372 0.0001039 0.00204
238 MESONEPHROS DEVELOPMENT 10 90 0.0001045 0.002044
239 INTERSPECIES INTERACTION BETWEEN ORGANISMS 34 662 0.0001101 0.002134
240 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 34 662 0.0001101 0.002134
241 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 30 554 0.0001111 0.002145
242 EMBRYONIC PATTERN SPECIFICATION 8 58 0.0001117 0.002147
243 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 13 148 0.0001191 0.00228
244 NEGATIVE REGULATION OF CELLULAR SENESCENCE 4 11 0.0001232 0.00235
245 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 12 129 0.0001254 0.002381
246 CELLULAR RESPONSE TO NITROGEN COMPOUND 28 505 0.0001263 0.002389
247 PROTEIN COMPLEX SUBUNIT ORGANIZATION 63 1527 0.0001284 0.00242
248 RESPONSE TO REACTIVE OXYGEN SPECIES 15 191 0.0001305 0.002448
249 NEGATIVE REGULATION OF CELL GROWTH 14 170 0.0001317 0.002451
250 DNA REPAIR 27 480 0.0001314 0.002451
251 ANTIGEN PROCESSING AND PRESENTATION 16 213 0.0001324 0.002454
252 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 11 111 0.0001356 0.002504
253 EXOCRINE SYSTEM DEVELOPMENT 7 45 0.0001384 0.002545
254 SALIVARY GLAND DEVELOPMENT 6 32 0.0001436 0.00261
255 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 8 60 0.0001425 0.00261
256 REGULATION OF BINDING 19 283 0.0001433 0.00261
257 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 12 131 0.0001452 0.002628
258 REGULATION OF DNA BIOSYNTHETIC PROCESS 10 94 0.0001508 0.00272
259 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 7 46 0.0001596 0.002868
260 MITOCHONDRION ORGANIZATION 31 594 0.000166 0.002971
261 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 16 218 0.000173 0.003084
262 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 4 12 0.0001811 0.003204
263 POSITIVE REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 4 12 0.0001811 0.003204
264 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 7 47 0.0001835 0.003233
265 MITOCHONDRIAL TRANSPORT 14 177 0.0002013 0.003517
266 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN 14 177 0.0002013 0.003517
267 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 13 156 0.0002018 0.003517
268 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 7 48 0.0002101 0.003647
269 RESPONSE TO CYTOKINE 35 714 0.0002142 0.003705
270 SKELETAL SYSTEM MORPHOGENESIS 15 201 0.0002285 0.003939
271 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 76 1977 0.0002343 0.004023
272 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 10 100 0.0002518 0.004307
273 MITOTIC CELL CYCLE ARREST 4 13 0.0002563 0.004369
274 MACROMOLECULAR COMPLEX DISASSEMBLY 14 182 0.0002686 0.004561
275 NEGATIVE REGULATION OF KINASE ACTIVITY 17 250 0.0002724 0.004609
276 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 8 66 0.0002797 0.004698
277 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 8 66 0.0002797 0.004698
278 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 11 121 0.0002908 0.004867
279 RESPONSE TO INORGANIC SUBSTANCE 26 479 0.0003033 0.005059
280 REPRODUCTION 54 1297 0.0003212 0.005337
281 REGULATION OF CYTOPLASMIC TRANSPORT 26 481 0.0003233 0.005353
282 REGULATION OF CYTOKINE PRODUCTION 29 563 0.0003322 0.005462
283 POSITIVE REGULATION OF CHROMATIN MODIFICATION 9 85 0.0003321 0.005462
284 POSITIVE REGULATION OF KINASE ACTIVITY 26 482 0.0003337 0.005467
285 LEUKOCYTE CELL CELL ADHESION 17 255 0.000343 0.0056
286 POSITIVE REGULATION OF MITOTIC SISTER CHROMATID SEPARATION 4 14 0.0003516 0.005622
287 POSITIVE REGULATION OF MITOTIC METAPHASE ANAPHASE TRANSITION 4 14 0.0003516 0.005622
288 CELLULAR RESPONSE TO LIPID 25 457 0.000351 0.005622
289 POSITIVE REGULATION OF METAPHASE ANAPHASE TRANSITION OF CELL CYCLE 4 14 0.0003516 0.005622
290 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 10 104 0.0003466 0.005622
291 LYMPHOCYTE DIFFERENTIATION 15 209 0.0003477 0.005622
292 RESPONSE TO LIGHT STIMULUS 18 280 0.0003604 0.005743
293 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 9 86 0.0003626 0.005759
294 CELLULAR RESPONSE TO TOXIC SUBSTANCE 5 25 0.0003816 0.005938
295 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 5 25 0.0003816 0.005938
296 CARBOHYDRATE DERIVATIVE BIOSYNTHETIC PROCESS 30 595 0.0003769 0.005938
297 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 22 381 0.0003788 0.005938
298 MITOTIC SPINDLE ORGANIZATION 8 69 0.0003807 0.005938
299 IRON ION HOMEOSTASIS 8 69 0.0003807 0.005938
300 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 6 38 0.000384 0.005956
301 TISSUE REMODELING 9 87 0.0003954 0.006052
302 MORPHOGENESIS OF A BRANCHING STRUCTURE 13 167 0.0003926 0.006052
303 INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR 7 53 0.0003938 0.006052
304 MYELOID CELL DIFFERENTIATION 14 189 0.0003947 0.006052
305 RESPONSE TO ESTRADIOL 12 146 0.0003984 0.006078
306 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 126 0.0004126 0.006274
307 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 14 190 0.0004164 0.00631
308 RESPONSE TO METAL ION 20 333 0.0004196 0.006338
309 RESPONSE TO EXTERNAL STIMULUS 70 1821 0.0004244 0.006381
310 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 15 213 0.0004252 0.006381
311 RESPONSE TO NITROGEN COMPOUND 39 859 0.0004415 0.006605
312 B CELL DIFFERENTIATION 9 89 0.0004684 0.006961
313 SENSORY ORGAN DEVELOPMENT 26 493 0.0004693 0.006961
314 ACTIVATION OF ANAPHASE PROMOTING COMPLEX ACTIVITY 4 15 0.0004697 0.006961
315 HEPATICOBILIARY SYSTEM DEVELOPMENT 11 128 0.000472 0.006973
316 VASCULATURE DEVELOPMENT 25 469 0.0005137 0.007563
317 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 15 217 0.0005169 0.007587
318 REGULATION OF MITOCHONDRION ORGANIZATION 15 218 0.0005423 0.007935
319 CELLULAR RESPONSE TO LIGHT STIMULUS 9 91 0.0005521 0.008052
320 SMAD PROTEIN SIGNAL TRANSDUCTION 7 56 0.0005545 0.008063
321 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 12 152 0.0005733 0.008311
322 REGULATION OF DNA DEPENDENT DNA REPLICATION 6 41 0.000586 0.008468
323 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 15 220 0.0005963 0.00859
324 REGULATION OF CYTOSKELETON ORGANIZATION 26 502 0.0006142 0.008821
325 RESPONSE TO AMINO ACID 10 112 0.0006264 0.008968
326 POSITIVE REGULATION OF HYDROLASE ACTIVITY 40 905 0.0006319 0.009019
327 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 12 154 0.0006443 0.009169
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 93 1737 6.383e-12 5.93e-09
2 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE REGULATOR ACTIVITY 10 28 9.978e-10 4.635e-07
3 PROTEIN COMPLEX BINDING 56 935 3.585e-09 1.11e-06
4 KINASE BINDING 39 606 1.569e-07 3.643e-05
5 MACROMOLECULAR COMPLEX BINDING 68 1399 2.766e-07 5.14e-05
6 PROTEIN KINASE ACTIVITY 38 640 1.64e-06 0.0002539
7 IDENTICAL PROTEIN BINDING 58 1209 3.418e-06 0.0004536
8 UBIQUITIN LIKE PROTEIN LIGASE BINDING 21 264 5.154e-06 0.0005985
9 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 5 12 7.5e-06 0.0007742
10 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 7 30 8.661e-06 0.0008046
11 TRANSCRIPTION FACTOR BINDING 31 524 1.621e-05 0.001369
12 CORE PROMOTER BINDING 14 152 3.91e-05 0.002622
13 KINASE ACTIVITY 42 842 3.396e-05 0.002622
14 DOUBLE STRANDED DNA BINDING 39 764 3.952e-05 0.002622
15 SMAD BINDING 9 72 9.214e-05 0.005046
16 PROTEIN DIMERIZATION ACTIVITY 51 1149 0.0001032 0.005046
17 KINASE REGULATOR ACTIVITY 15 186 9.698e-05 0.005046
18 PROTEIN SERINE THREONINE KINASE ACTIVITY 26 445 9.508e-05 0.005046
19 CORE PROMOTER PROXIMAL REGION DNA BINDING 23 371 9.982e-05 0.005046
20 I SMAD BINDING 4 11 0.0001232 0.005725
21 REGULATORY REGION NUCLEIC ACID BINDING 39 818 0.0001669 0.007046
22 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 45 992 0.0001646 0.007046
23 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 32 629 0.0002069 0.008009
24 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 6 34 0.0002041 0.008009
25 R SMAD BINDING 5 23 0.0002521 0.009369
26 PROTEIN HOMODIMERIZATION ACTIVITY 35 722 0.0002639 0.009382
27 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 7 50 0.0002727 0.009382
28 RIBONUCLEOTIDE BINDING 72 1860 0.0002848 0.009436
29 ENZYME REGULATOR ACTIVITY 43 959 0.0002946 0.009436
NumGOOverlapSizeP ValueAdj. P Value
1 ANAPHASE PROMOTING COMPLEX 10 22 5.649e-11 3.299e-08
2 NUCLEAR UBIQUITIN LIGASE COMPLEX 12 42 4.008e-10 1.17e-07
3 TRANSCRIPTION FACTOR COMPLEX 26 298 6.404e-08 9.35e-06
4 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 9 31 5.557e-08 9.35e-06
5 CHROMOSOMAL REGION 27 330 1.336e-07 1.318e-05
6 SPINDLE 25 289 1.354e-07 1.318e-05
7 ANCHORING JUNCTION 34 489 1.684e-07 1.405e-05
8 NUCLEAR CHROMOSOME 34 523 7.95e-07 5.804e-05
9 CELL SUBSTRATE JUNCTION 28 398 1.668e-06 0.0001082
10 CHROMOSOME 47 880 1.867e-06 0.000109
11 SPINDLE POLE 14 126 4.552e-06 0.0002215
12 MCM COMPLEX 5 11 4.47e-06 0.0002215
13 CULLIN RING UBIQUITIN LIGASE COMPLEX 14 150 3.375e-05 0.001516
14 SPINDLE MIDZONE 6 27 5.231e-05 0.002182
15 MITOTIC SPINDLE 8 55 7.588e-05 0.002664
16 TRANSFERASE COMPLEX 36 703 7.355e-05 0.002664
17 CHROMATIN 26 441 8.212e-05 0.002664
18 CHROMOSOME TELOMERIC REGION 14 162 7.858e-05 0.002664
19 PROTEIN KINASE COMPLEX 10 90 0.0001045 0.003214
20 COHESIN COMPLEX 4 11 0.0001232 0.003427
21 MHC CLASS I PROTEIN COMPLEX 4 11 0.0001232 0.003427
22 NUCLEAR CHROMOSOME TELOMERIC REGION 12 132 0.000156 0.004142
23 CONDENSED CHROMOSOME 15 195 0.0001641 0.004166
24 CONDENSED CHROMOSOME OUTER KINETOCHORE 4 12 0.0001811 0.004407
25 PERINUCLEAR REGION OF CYTOPLASM 32 642 0.0002969 0.006936
26 CONDENSED NUCLEAR CHROMOSOME 9 85 0.0003321 0.007459

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 85 124 6.009e-107 3.125e-105
2 Cellular_senescence_hsa04218 39 160 3.808e-27 9.902e-26
3 Oocyte_meiosis_hsa04114 29 124 6.074e-20 1.053e-18
4 p53_signaling_pathway_hsa04115 18 68 6.917e-14 8.992e-13
5 FoxO_signaling_pathway_hsa04068 22 132 3.046e-12 3.168e-11
6 TGF_beta_signaling_pathway_hsa04350 17 84 3.733e-11 3.236e-10
7 Hippo_signaling_pathway_hsa04390 20 154 2.877e-09 2.137e-08
8 PI3K_Akt_signaling_pathway_hsa04151 29 352 3.93e-08 2.554e-07
9 Wnt_signaling_pathway_hsa04310 16 146 1.153e-06 6.664e-06
10 ErbB_signaling_pathway_hsa04012 12 85 1.749e-06 9.096e-06
11 Adherens_junction_hsa04520 10 72 1.48e-05 6.995e-05
12 HIF_1_signaling_pathway_hsa04066 11 100 5.227e-05 0.0002265
13 Focal_adhesion_hsa04510 16 199 5.941e-05 0.0002376
14 Jak_STAT_signaling_pathway_hsa04630 14 162 7.858e-05 0.0002919
15 Apoptosis_hsa04210 12 138 0.000237 0.0007926
16 MAPK_signaling_pathway_hsa04010 19 295 0.0002439 0.0007926
17 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 0.0009421 0.002882
18 Ferroptosis_hsa04216 4 40 0.01898 0.05348
19 Calcium_signaling_pathway_hsa04020 10 182 0.01954 0.05348
20 Endocytosis_hsa04144 12 244 0.02444 0.06354
21 Hedgehog_signaling_pathway_hsa04340 4 47 0.03223 0.07982
22 Notch_signaling_pathway_hsa04330 4 48 0.03448 0.08149
23 Cytokine_cytokine_receptor_interaction_hsa04060 12 270 0.04718 0.1067
24 Tight_junction_hsa04530 8 170 0.07272 0.1576
25 Ras_signaling_pathway_hsa04014 10 232 0.0775 0.1612
26 Rap1_signaling_pathway_hsa04015 9 206 0.08522 0.1656
27 Mitophagy_animal_hsa04137 4 65 0.08596 0.1656
28 Regulation_of_actin_cytoskeleton_hsa04810 9 208 0.08918 0.1656
29 Apelin_signaling_pathway_hsa04371 6 137 0.1419 0.2544
30 ECM_receptor_interaction_hsa04512 4 82 0.1602 0.2776
31 Gap_junction_hsa04540 4 88 0.1906 0.3146
32 mTOR_signaling_pathway_hsa04150 6 151 0.1936 0.3146
33 AMPK_signaling_pathway_hsa04152 5 121 0.201 0.3167
34 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.2281 0.3489
35 Necroptosis_hsa04217 6 164 0.247 0.3616
36 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.2504 0.3616
37 TNF_signaling_pathway_hsa04668 4 108 0.3018 0.4242
38 Cell_adhesion_molecules_.CAMs._hsa04514 5 145 0.317 0.4294
39 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.322 0.4294
40 Phagosome_hsa04145 5 152 0.3525 0.4583
41 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.4087 0.5183
42 VEGF_signaling_pathway_hsa04370 2 59 0.4501 0.5573
43 Lysosome_hsa04142 3 123 0.6159 0.7117
44 Sphingolipid_signaling_pathway_hsa04071 2 118 0.8104 0.8966
45 Autophagy_animal_hsa04140 2 128 0.8447 0.915
46 cAMP_signaling_pathway_hsa04024 3 198 0.887 0.9225
47 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.9942 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

UCA1

hsa-miR-103a-3p;hsa-miR-1224-5p;hsa-miR-136-5p;hsa-miR-140-3p;hsa-miR-148b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-185-5p;hsa-miR-191-5p;hsa-miR-26a-5p;hsa-miR-3065-5p;hsa-miR-33b-5p;hsa-miR-340-5p;hsa-miR-362-5p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-500a-5p;hsa-miR-539-5p;hsa-miR-582-5p;hsa-miR-671-5p;hsa-miR-7-1-3p 21 CDK6 Sponge network 1.481 0.28957 0.112 0.76976 0.48
2

EGOT

hsa-miR-103a-3p;hsa-miR-1224-5p;hsa-miR-136-5p;hsa-miR-137;hsa-miR-148b-3p;hsa-miR-148b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-185-5p;hsa-miR-29b-3p;hsa-miR-33b-5p;hsa-miR-340-5p;hsa-miR-421;hsa-miR-501-3p;hsa-miR-7-1-3p 15 CDK6 Sponge network -1.196 0.1622 0.112 0.76976 0.394
3 RFPL1S hsa-let-7a-3p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-224-3p;hsa-miR-224-5p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-28-3p;hsa-miR-34a-5p;hsa-miR-429;hsa-miR-92a-3p;hsa-miR-93-5p 19 SMAD4 Sponge network -0.457 0.43621 -0.501 0.1224 0.384
4

UCA1

hsa-miR-101-5p;hsa-miR-125a-5p;hsa-miR-126-5p;hsa-miR-132-3p;hsa-miR-153-3p;hsa-miR-154-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-299-3p;hsa-miR-340-5p;hsa-miR-495-3p;hsa-miR-590-3p;hsa-miR-7-1-3p 14 TFDP2 Sponge network 1.481 0.28957 0.25 0.34904 0.372
5

UCA1

hsa-miR-135a-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-20b-5p;hsa-miR-296-5p;hsa-miR-340-5p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-495-3p;hsa-miR-590-3p;hsa-miR-7-1-3p 12 CCND1 Sponge network 1.481 0.28957 1.037 0.01709 0.349
6

DIO3OS

hsa-let-7g-3p;hsa-miR-132-3p;hsa-miR-15a-5p;hsa-miR-188-5p;hsa-miR-212-3p;hsa-miR-29b-2-5p;hsa-miR-330-3p;hsa-miR-501-5p;hsa-miR-671-5p;hsa-miR-769-5p 10 SMAD3 Sponge network 1.18 0.0997 -0.053 0.89869 0.344
7

HCG11

hsa-miR-148b-3p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-500b-5p;hsa-miR-590-3p 10 TGFB2 Sponge network -0.31 0.48859 -0.527 0.43869 0.319
8

PART1

hsa-miR-146a-5p;hsa-miR-146b-5p;hsa-miR-155-5p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-199b-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-214-5p;hsa-miR-224-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-27a-5p;hsa-miR-28-3p;hsa-miR-28-5p;hsa-miR-34a-5p;hsa-miR-34c-5p;hsa-miR-425-5p;hsa-miR-450b-5p;hsa-miR-508-3p;hsa-miR-92a-3p;hsa-miR-93-5p 23 SMAD4 Sponge network 2.634 0.03419 -0.501 0.1224 0.314
9

H19

hsa-miR-107;hsa-miR-136-3p;hsa-miR-148b-3p;hsa-miR-200a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-454-3p;hsa-miR-495-3p;hsa-miR-589-3p 10 TGFB2 Sponge network -0.02 0.98077 -0.527 0.43869 0.304
10

HCG11

hsa-let-7a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-340-5p;hsa-miR-362-5p;hsa-miR-664a-3p 10 GSK3B Sponge network -0.31 0.48859 -0.018 0.92408 0.254

Quest ID: ba6417b758fa06fd85dc57ed1c7d272a