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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p CCND2 0.62 3.0E-5 -2.43 0 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.5 0.0001
2 hsa-let-7b-5p CCND2 0.6 0.0014 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.0002
3 hsa-let-7b-5p NFATC1 0.6 0.0014 -1.85 0 miRNAWalker2 validate -0.2 0.02177
4 hsa-let-7e-5p DAAM1 0.86 6.0E-5 -0.94 0.00028 miRNAWalker2 validate -0.16 0.0074
5 hsa-let-7f-5p MYC 0.5 0.00356 -1.77 0 miRNAWalker2 validate -0.3 0.00594
6 hsa-let-7g-5p MYC 1.2 0 -1.77 0 miRNAWalker2 validate; miRTarBase -0.65 0
7 hsa-miR-101-3p FZD6 0.52 0.00376 0.39 0.09232 miRNAWalker2 validate; MirTarget -0.15 0.01797
8 hsa-miR-101-3p JUN 0.52 0.00376 -2.05 0 miRNAWalker2 validate -0.36 0
9 hsa-miR-103a-3p AXIN2 1.44 0 -1.7 6.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.43 2.0E-5
10 hsa-miR-106b-5p APC 2.47 0 -0.6 0.00012 miRNAWalker2 validate; miRTarBase -0.09 0.00265 23087084 miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma
11 hsa-miR-106b-5p CCND1 2.47 0 0.08 0.84033 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 0.01301 23087084 Furthermore miR-106b upregulation in hepatoma cells modulated entry into the G1/S transitional phase by upregulating cyclin D1 and downregulating APC
12 hsa-miR-106b-5p CCND2 2.47 0 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.72 0
13 hsa-miR-106b-5p MAPK9 2.47 0 -0.27 0.00867 miRNAWalker2 validate; miRNATAP -0.05 0.00427
14 hsa-miR-10a-5p MAPK8 1.15 0.00372 -0.08 0.76049 miRNAWalker2 validate -0.09 0.00367
15 hsa-miR-10b-5p PPP3CB -0.16 0.55501 -1.04 0 miRNAWalker2 validate -0.09 0.00054
16 hsa-miR-125a-5p MAPK8 0.6 0.01023 -0.08 0.76049 miRNAWalker2 validate -0.2 7.0E-5
17 hsa-miR-125a-5p PPP2R5E 0.6 0.01023 -0.28 0.05538 miRNAWalker2 validate -0.2 0
18 hsa-miR-125b-5p FRAT2 -1.16 0.00029 0.83 0 miRNAWalker2 validate; miRNATAP -0.14 0
19 hsa-miR-1301-3p CREBBP 2.55 0 -0.45 0.00069 miRNAWalker2 validate -0.06 0.0021
20 hsa-miR-1301-3p SKP1 2.55 0 -0.42 5.0E-5 miRNAWalker2 validate -0.06 0.00051
21 hsa-miR-130a-3p SMAD4 2.02 0 -0.59 0 miRNAWalker2 validate; miRNATAP -0.07 0.00035
22 hsa-miR-140-3p MAPK8 0.06 0.72772 -0.08 0.76049 miRNAWalker2 validate -0.14 0.03794
23 hsa-miR-140-5p EP300 0.84 4.0E-5 -0.26 0.13065 miRNAWalker2 validate -0.12 0.00415
24 hsa-miR-141-3p TCF7L1 5.02 0 -1.3 0.00022 miRNAWalker2 validate -0.29 0
25 hsa-miR-146a-5p SMAD4 1.2 0.00157 -0.59 0 miRNAWalker2 validate; miRTarBase -0.08 0
26 hsa-miR-148a-3p APC 1.27 0 -0.6 0.00012 miRNAWalker2 validate -0.12 2.0E-5
27 hsa-miR-148b-3p FBXW11 1.98 0 -0.61 0 miRNAWalker2 validate -0.15 0
28 hsa-miR-148b-3p ROCK1 1.98 0 -1.03 0 miRNAWalker2 validate -0.28 0 23233531 miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5 ROCK1 PIK3CA NRAS and CSF1
29 hsa-miR-149-5p JUN 2.94 0 -2.05 0 miRNAWalker2 validate; miRNATAP -0.16 1.0E-5
30 hsa-miR-150-5p EP300 -0.11 0.79935 -0.26 0.13065 miRNAWalker2 validate -0.08 0.00013
31 hsa-miR-155-5p APC 1.2 0.00086 -0.6 0.00012 miRNAWalker2 validate; miRTarBase; miRNATAP -0.06 0.0034
32 hsa-miR-155-5p SMAD2 1.2 0.00086 -0.22 0.04969 miRNAWalker2 validate; miRTarBase; MirTarget; mirMAP -0.05 0.0002 25283513; 22426647; 22426647 MiR-155 which targeted the SMAD2-3'UTR decreased the expression and function of SMAD2;Overexpression of miR-155 significantly reduced the protein levels of SMAD2 and repressed the activity of a luciferase reporter containing one of the two predicted miR-155 binding sites in SMAD2 3'-UTR indicating that SMAD2 may be a miR-155 target gene;Taken together these data suggest that miR-155 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting SMAD2 and its downregulation in gastric cancer cells may be partly ascribed to DNA methylation
33 hsa-miR-155-5p SMAD3 1.2 0.00086 -0.15 0.56924 miRNAWalker2 validate -0.17 0
34 hsa-miR-155-5p SMAD4 1.2 0.00086 -0.59 0 miRNAWalker2 validate -0.09 0
35 hsa-miR-15a-5p BTRC 2.35 0 -0.2 0.10365 miRNAWalker2 validate; MirTarget; miRNATAP -0.06 0.01057
36 hsa-miR-15a-5p CCND2 2.35 0 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.56 0
37 hsa-miR-15a-5p JUN 2.35 0 -2.05 0 miRNAWalker2 validate -0.32 0
38 hsa-miR-15b-5p CCND1 1.57 0 0.08 0.84033 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.27 0.0019
39 hsa-miR-16-5p AXIN2 1.76 0 -1.7 6.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.75 0
40 hsa-miR-16-5p BTRC 1.76 0 -0.2 0.10365 miRNAWalker2 validate; MirTarget; miRNATAP -0.07 0.00757
41 hsa-miR-16-5p CAMK2G 1.76 0 -0.52 0.0078 miRNAWalker2 validate -0.19 1.0E-5
42 hsa-miR-16-5p CCND2 1.76 0 -2.43 0 miRNAWalker2 validate; miRNATAP -0.62 0
43 hsa-miR-16-5p FBXW11 1.76 0 -0.61 0 miRNAWalker2 validate -0.1 5.0E-5
44 hsa-miR-16-5p JUN 1.76 0 -2.05 0 miRNAWalker2 validate -0.38 0
45 hsa-miR-16-5p PPP2R5C 1.76 0 -0.52 0 miRNAWalker2 validate; miRNATAP -0.08 0.00057
46 hsa-miR-17-3p PRKCA 2.27 0 -1.04 0.00033 miRNAWalker2 validate -0.16 0.00493
47 hsa-miR-17-5p CCND2 3.27 0 -2.43 0 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.58 0
48 hsa-miR-17-5p NFAT5 3.27 0 -0.39 0.03775 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.13 0
49 hsa-miR-17-5p PRICKLE1 3.27 0 -1.64 0.00013 miRNAWalker2 validate -0.49 0
50 hsa-miR-17-5p SMAD3 3.27 0 -0.15 0.56924 miRNAWalker2 validate -0.07 0.04926
51 hsa-miR-181b-5p EP300 2.49 0 -0.26 0.13065 miRNAWalker2 validate -0.09 0.00117
52 hsa-miR-182-5p CCND2 3.54 0 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.42 0
53 hsa-miR-185-5p RHOA 2.34 0 -0.23 0.03059 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.08 0.00062
54 hsa-miR-185-5p WNT5B 2.34 0 -2.11 3.0E-5 miRNAWalker2 validate -0.61 0
55 hsa-miR-186-5p APC 1.47 0 -0.6 0.00012 miRNAWalker2 validate -0.2 0
56 hsa-miR-186-5p CSNK1A1 1.47 0 -0.45 0.00045 miRNAWalker2 validate; miRNATAP -0.13 4.0E-5
57 hsa-miR-186-5p SMAD4 1.47 0 -0.59 0 miRNAWalker2 validate; mirMAP -0.11 0.00087
58 hsa-miR-18a-5p DAAM2 3.79 0 -2.23 0 miRNAWalker2 validate -0.33 0
59 hsa-miR-18a-5p SMAD3 3.79 0 -0.15 0.56924 miRNAWalker2 validate -0.14 6.0E-5
60 hsa-miR-192-5p FZD1 2.69 0 -0.43 0.07997 miRNAWalker2 validate -0.16 1.0E-5
61 hsa-miR-192-5p FZD4 2.69 0 -0.83 0.00068 miRNAWalker2 validate; mirMAP -0.08 0.0167
62 hsa-miR-192-5p FZD7 2.69 0 -2.08 0 miRNAWalker2 validate -0.26 0
63 hsa-miR-192-5p PRICKLE1 2.69 0 -1.64 0.00013 miRNAWalker2 validate -0.46 0
64 hsa-miR-192-5p TBL1X 2.69 0 -1.42 0 miRNAWalker2 validate -0.11 0.00416
65 hsa-miR-193b-3p BTRC 2.26 0 -0.2 0.10365 miRNAWalker2 validate -0.06 0.00079
66 hsa-miR-193b-3p EP300 2.26 0 -0.26 0.13065 miRNAWalker2 validate -0.11 8.0E-5
67 hsa-miR-193b-3p PRKCA 2.26 0 -1.04 0.00033 miRNAWalker2 validate -0.18 6.0E-5
68 hsa-miR-193b-3p SMAD3 2.26 0 -0.15 0.56924 miRNAWalker2 validate -0.09 0.03101
69 hsa-miR-195-5p CCND1 -1.45 0 0.08 0.84033 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.23 0.00278 21350001; 19441017 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;Silencing of cyclin D1 CDK6 or E2F3 phenocopied the effect of miR-195 whereas overexpression of these proteins attenuated miR-195-induced G1 arrest
70 hsa-miR-199a-5p SMAD4 0.59 0.06748 -0.59 0 miRNAWalker2 validate; miRTarBase; miRanda -0.07 0.00013
71 hsa-miR-19a-3p CCND1 3.42 0 0.08 0.84033 miRNAWalker2 validate; miRTarBase; miRNATAP -0.13 0.03027 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression
72 hsa-miR-19a-3p SMAD4 3.42 0 -0.59 0 miRNAWalker2 validate; miRTarBase; mirMAP; miRNATAP -0.05 0.00319
73 hsa-miR-19b-1-5p CCND1 2.58 0 0.08 0.84033 miRNAWalker2 validate; miRTarBase -0.15 0.02853
74 hsa-miR-19b-3p CCND2 2.5 0 -2.43 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.64 0
75 hsa-miR-19b-3p DAAM2 2.5 0 -2.23 0 miRNAWalker2 validate -0.6 0
76 hsa-miR-19b-3p PRKACB 2.5 0 -1.12 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.27 0
77 hsa-miR-200a-3p CTNNB1 4.59 0 -0.22 0.11826 miRNAWalker2 validate; miRTarBase; miRNATAP -0.06 0
78 hsa-miR-200a-3p TCF7L1 4.59 0 -1.3 0.00022 miRNAWalker2 validate -0.32 0
79 hsa-miR-200b-3p TCF7L1 3.78 0 -1.3 0.00022 miRNAWalker2 validate -0.34 0
80 hsa-miR-200c-3p RHOA 3.5 0 -0.23 0.03059 miRNAWalker2 validate; MirTarget; miRNATAP -0.08 0
81 hsa-miR-200c-3p TCF7L1 3.5 0 -1.3 0.00022 miRNAWalker2 validate -0.32 0
82 hsa-miR-20a-5p CCND2 3.16 0 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.55 0
83 hsa-miR-21-5p APC 2.74 0 -0.6 0.00012 miRNAWalker2 validate -0.21 0
84 hsa-miR-21-5p DAAM1 2.74 0 -0.94 0.00028 miRNAWalker2 validate -0.3 0
85 hsa-miR-21-5p NFAT5 2.74 0 -0.39 0.03775 miRNAWalker2 validate; mirMAP -0.14 0.00102
86 hsa-miR-21-5p PRICKLE2 2.74 0 -2.5 0 miRNAWalker2 validate; MirTarget -0.32 1.0E-5
87 hsa-miR-214-3p TP53 -0.18 0.64249 0.17 0.48779 miRNAWalker2 validate; miRTarBase -0.09 0.00577 22241525; 22927443 Six differentially expressed miRNAs affected the TP53 pathway miR-122 miR-214 miR-372 miR-15b let-7e miR-17 P < 0.001;Enforcing expression of miR-214 increases whereas knockdown of miR-214 decreases OCSC population and self-renewal as well as the Nanog level preferentially in wild-type p53 cell lines
88 hsa-miR-215-5p FZD1 2.31 0 -0.43 0.07997 miRNAWalker2 validate -0.05 0.03905
89 hsa-miR-215-5p FZD7 2.31 0 -2.08 0 miRNAWalker2 validate -0.15 0
90 hsa-miR-215-5p PRICKLE1 2.31 0 -1.64 0.00013 miRNAWalker2 validate -0.25 0
91 hsa-miR-221-3p DVL2 0.45 0.09098 0.08 0.50594 miRNAWalker2 validate -0.07 0.00167 21487968; 21487968 MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2;We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP
92 hsa-miR-221-3p LRP6 0.45 0.09098 -0.43 0.00843 miRNAWalker2 validate -0.1 0.00114
93 hsa-miR-221-3p TP53 0.45 0.09098 0.17 0.48779 miRNAWalker2 validate -0.12 0.01057 20880178; 20880178; 20880178; 20880178; 25431954; 25431954; 24324033; 24324033; 24324033; 24324033 Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression;The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed;The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression;The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma;We explored the regulation of p53 by Notch3 signalling in three HCC cell lines HepG2 SNU398 and Hep3B.We found that Notch3 regulates p53 at post-transcriptional level controlling both Cyclin G1 expression and the feed-forward circuit involving p53 miR-221 and MDM2;In this study MDM2 E3 ubiquitin-protein ligase homolog a known p53 TP53 modulator is identified as a direct target of miR-221 and a feed-forward loop is described that sustains miR-221 aberrant expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression;Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines;These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation
94 hsa-miR-222-3p TP53 0.85 0.00267 0.17 0.48779 miRNAWalker2 validate -0.12 0.0059
95 hsa-miR-23a-3p NLK 1 0 0.77 0 miRNAWalker2 validate; MirTarget -0.12 0.00269
96 hsa-miR-24-2-5p PRKCA 2.07 0 -1.04 0.00033 miRNAWalker2 validate -0.19 0.00038
97 hsa-miR-24-3p FZD4 1 0 -0.83 0.00068 miRNAWalker2 validate -0.36 0
98 hsa-miR-26a-5p CTBP1 0.05 0.75263 0.31 0.00466 miRNAWalker2 validate -0.11 0.00326
99 hsa-miR-26a-5p LRP6 0.05 0.75263 -0.43 0.00843 miRNAWalker2 validate -0.11 0.03549
100 hsa-miR-26b-5p JUN 0.89 0 -2.05 0 miRNAWalker2 validate -0.25 0.00101 21901137 When c-Jun N-terminal kinase activity was inhibited using SP600125 expression of miR-26b was induced following γ-irradiation in H1299 cells
101 hsa-miR-26b-5p PLCB4 0.89 0 -3.77 0 miRNAWalker2 validate -0.77 0
102 hsa-miR-26b-5p SFRP4 0.89 0 -1.42 0.14414 miRNAWalker2 validate -1.21 0
103 hsa-miR-27a-3p APC 1.67 0 -0.6 0.00012 miRNAWalker2 validate; miRTarBase; miRNATAP -0.07 0.02856
104 hsa-miR-27b-3p CCND3 0.2 0.29563 0.14 0.39731 miRNAWalker2 validate -0.13 0.00231
105 hsa-miR-27b-3p CUL1 0.2 0.29563 -0.12 0.21523 miRNAWalker2 validate -0.05 0.03163
106 hsa-miR-29c-3p JUN -0.01 0.971 -2.05 0 miRNAWalker2 validate -0.27 0
107 hsa-miR-301a-3p CCND2 2.81 0 -2.43 0 miRNAWalker2 validate -0.49 0
108 hsa-miR-30a-5p CTNNB1 -0.88 0.00051 -0.22 0.11826 miRNAWalker2 validate -0.06 0.03989
109 hsa-miR-30a-5p PPP2R5C -0.88 0.00051 -0.52 0 miRNAWalker2 validate -0.06 0.00148
110 hsa-miR-30c-2-3p RAC3 -1.67 0 2.75 0 miRNAWalker2 validate -0.12 0.03934
111 hsa-miR-320a CCND2 0.44 0.03902 -2.43 0 miRNAWalker2 validate; mirMAP; miRNATAP -0.37 4.0E-5
112 hsa-miR-320a MYC 0.44 0.03902 -1.77 0 miRNAWalker2 validate -0.27 0.00203
113 hsa-miR-320b MYC 1.56 0 -1.77 0 miRNAWalker2 validate -0.21 0.00143
114 hsa-miR-324-3p CCND2 2.09 0 -2.43 0 miRNAWalker2 validate -0.57 0
115 hsa-miR-324-3p CSNK1A1 2.09 0 -0.45 0.00045 miRNAWalker2 validate -0.05 0.01109
116 hsa-miR-335-5p CCND2 1.77 0 -2.43 0 miRNAWalker2 validate -0.2 8.0E-5
117 hsa-miR-335-5p DAAM1 1.77 0 -0.94 0.00028 miRNAWalker2 validate; MirTarget; miRNATAP -0.09 0.00741
118 hsa-miR-335-5p FZD1 1.77 0 -0.43 0.07997 miRNAWalker2 validate -0.07 0.02585
119 hsa-miR-335-5p MYC 1.77 0 -1.77 0 miRNAWalker2 validate -0.16 0.00141
120 hsa-miR-335-5p PPP2R5A 1.77 0 -0.9 0 miRNAWalker2 validate -0.06 0.00119
121 hsa-miR-335-5p PRICKLE2 1.77 0 -2.5 0 miRNAWalker2 validate -0.22 0
122 hsa-miR-335-5p SFRP1 1.77 0 -4.72 0 miRNAWalker2 validate -0.22 0.01515
123 hsa-miR-335-5p TBL1X 1.77 0 -1.42 0 miRNAWalker2 validate -0.09 0.00574
124 hsa-miR-335-5p WNT9A 1.77 0 -2.07 0 miRNAWalker2 validate -0.22 9.0E-5
125 hsa-miR-338-3p CCND1 0.45 0.14458 0.08 0.84033 miRNAWalker2 validate; miRTarBase; miRanda -0.15 0.02359
126 hsa-miR-342-3p JUN 1.49 0 -2.05 0 miRNAWalker2 validate -0.13 0.00731
127 hsa-miR-34a-5p AXIN2 1.9 0 -1.7 6.0E-5 miRNAWalker2 validate; miRTarBase -0.32 9.0E-5 23624843; 23624843 Suppression of Axin2 by p53 or miR-34 increases nuclear GSK-3β abundance and leads to decreased Snail expression in colorectal cancer cells;Conversely expression of the non-coding UTR of Axin2 causes depletion of endogenous miR-34 via the miR-sponge effect together with increased Axin2 function supporting that the RNA-RNA interactions with Axin2 transcripts act as an endogenous decoy for miR-34
128 hsa-miR-34a-5p CTNNB1 1.9 0 -0.22 0.11826 miRNAWalker2 validate -0.07 0.01098
129 hsa-miR-34a-5p MAP3K7 1.9 0 -0.05 0.70227 miRNAWalker2 validate -0.08 0.00085
130 hsa-miR-34a-5p MYC 1.9 0 -1.77 0 miRNAWalker2 validate; miRTarBase -0.36 0 22235332; 22235332; 22235332; 22235332; 22159222; 22159222; 22159222; 22159222 MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells;miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays;Overexpression of c-Myc reversed miR-34a suppression of RhoA expression suggesting that miR-34a inhibits invasion by suppressing RhoA through c-Myc miR-34a was also found to repress c-Myc-pTEFB transcription elongation complex indicating one of the mechanisms by which miR-34a has profound effects on cellular function;This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex;MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma;miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays;Overexpression of c-Myc reversed miR-34a suppression of RhoA expression and inhibition of cell invasion suggesting that miR-34a inhibits invasion by suppressing RhoA through c-Myc miR-34a was also found to repress the c-Myc-P-TEFb transcription elongation complex indicating one of the mechanisms by which miR-34a has profound effects on cellular functions;Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc
131 hsa-miR-34a-5p PPP3R1 1.9 0 -0.03 0.76057 miRNAWalker2 validate -0.07 2.0E-5
132 hsa-miR-361-3p NFATC3 1.07 0 -0.34 0.00548 miRNAWalker2 validate -0.19 0
133 hsa-miR-365a-3p CCND1 -0.04 0.85911 0.08 0.84033 miRNAWalker2 validate; miRTarBase -0.21 0.02249
134 hsa-miR-374b-5p CCND1 0.07 0.72267 0.08 0.84033 miRNAWalker2 validate; MirTarget -0.42 0.00013
135 hsa-miR-375 PRKCA 1.14 0.05123 -1.04 0.00033 miRNAWalker2 validate -0.06 0.02003 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A
136 hsa-miR-378a-3p CCND2 -0.11 0.71619 -2.43 0 miRNAWalker2 validate -0.26 2.0E-5
137 hsa-miR-421 PPP2CB 1.18 1.0E-5 -0.78 0 miRNAWalker2 validate; miRanda -0.09 0.00054
138 hsa-miR-423-5p CCND2 0.96 0 -2.43 0 miRNAWalker2 validate -0.68 0
139 hsa-miR-423-5p MYC 0.96 0 -1.77 0 miRNAWalker2 validate -0.59 0
140 hsa-miR-425-5p PPP2CB 3.07 0 -0.78 0 miRNAWalker2 validate -0.19 0
141 hsa-miR-429 MYC 4.49 0 -1.77 0 miRNAWalker2 validate -0.27 0 21684154; 21684154; 21684154 miR-429 modulates the expression of c-myc in human gastric carcinoma cells;SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots;miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells
142 hsa-miR-429 TCF7L1 4.49 0 -1.3 0.00022 miRNAWalker2 validate -0.31 0
143 hsa-miR-450a-5p FBXW11 2 0 -0.61 0 miRNAWalker2 validate -0.11 0
144 hsa-miR-454-3p SMAD4 2.47 0 -0.59 0 miRNAWalker2 validate; miRNATAP -0.07 0.00169
145 hsa-miR-484 CAMK2D 1.82 0 -0.89 3.0E-5 miRNAWalker2 validate -0.18 3.0E-5
146 hsa-miR-484 PPP2R5A 1.82 0 -0.9 0 miRNAWalker2 validate -0.17 0
147 hsa-miR-484 SMAD2 1.82 0 -0.22 0.04969 miRNAWalker2 validate -0.06 0.01266
148 hsa-miR-505-3p PRKCA 1.45 0 -1.04 0.00033 miRNAWalker2 validate -0.17 0.00317
149 hsa-miR-584-5p ROCK1 2.73 0 -1.03 0 miRNAWalker2 validate; miRTarBase -0.08 8.0E-5
150 hsa-miR-590-3p PPP2R5A 2.59 0 -0.9 0 miRNAWalker2 validate -0.15 0
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 71 351 3.368e-97 1.567e-93
2 CANONICAL WNT SIGNALING PATHWAY 34 95 1.156e-53 2.689e-50
3 REGULATION OF WNT SIGNALING PATHWAY 45 310 6.758e-52 1.048e-48
4 NON CANONICAL WNT SIGNALING PATHWAY 36 140 7.969e-51 9.27e-48
5 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 32 197 4.625e-38 4.304e-35
6 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 33 236 5.225e-37 4.052e-34
7 POSITIVE REGULATION OF RESPONSE TO STIMULUS 63 1929 2.423e-34 1.611e-31
8 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 48 1021 4.922e-32 2.863e-29
9 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 55 1492 7.468e-32 3.861e-29
10 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 57 1672 2.074e-31 9.651e-29
11 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 26 162 9.692e-31 4.1e-28
12 POSITIVE REGULATION OF GENE EXPRESSION 57 1733 1.374e-30 5.326e-28
13 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 17 39 9.366e-29 3.352e-26
14 POSITIVE REGULATION OF CELL COMMUNICATION 52 1532 3.919e-28 1.302e-25
15 REGULATION OF PROTEIN MODIFICATION PROCESS 54 1710 7.853e-28 2.436e-25
16 REGULATION OF ORGAN MORPHOGENESIS 26 242 4.847e-26 1.41e-23
17 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 53 1805 1.032e-25 2.824e-23
18 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 44 1135 1.147e-25 2.965e-23
19 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 20 110 6.601e-25 1.617e-22
20 NEGATIVE REGULATION OF CELL COMMUNICATION 44 1192 8.391e-25 1.952e-22
21 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 46 1360 1.93e-24 4.276e-22
22 REGULATION OF PHOSPHORUS METABOLIC PROCESS 49 1618 4.327e-24 9.151e-22
23 REGULATION OF CELL DIFFERENTIATION 47 1492 1.033e-23 2.089e-21
24 TISSUE DEVELOPMENT 47 1518 2.148e-23 4.165e-21
25 EPITHELIUM DEVELOPMENT 38 945 1.703e-22 3.169e-20
26 POSITIVE REGULATION OF MOLECULAR FUNCTION 49 1791 3.7e-22 6.621e-20
27 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 39 1036 4.311e-22 7.164e-20
28 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 39 1036 4.311e-22 7.164e-20
29 TISSUE MORPHOGENESIS 30 533 9.54e-22 1.531e-19
30 MORPHOGENESIS OF AN EPITHELIUM 27 400 1.267e-21 1.966e-19
31 TUBE MORPHOGENESIS 25 323 1.717e-21 2.578e-19
32 INTRACELLULAR SIGNAL TRANSDUCTION 45 1572 6.331e-21 9.206e-19
33 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 46 1656 6.583e-21 9.282e-19
34 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 39 1142 1.369e-20 1.874e-18
35 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 39 1152 1.862e-20 2.475e-18
36 REGULATION OF CELL CYCLE 36 949 2.016e-20 2.606e-18
37 TUBE DEVELOPMENT 29 552 3.404e-20 4.168e-18
38 REGULATION OF CELLULAR PROTEIN LOCALIZATION 29 552 3.404e-20 4.168e-18
39 ORGAN MORPHOGENESIS 34 841 4.119e-20 4.914e-18
40 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 11 22 8.421e-20 9.796e-18
41 REGULATION OF EMBRYONIC DEVELOPMENT 17 114 9.663e-20 1.097e-17
42 POSITIVE REGULATION OF CELL DIFFERENTIATION 33 823 2.131e-19 2.361e-17
43 REGULATION OF CELL PROLIFERATION 42 1496 4.291e-19 4.643e-17
44 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 28 554 4.684e-19 4.953e-17
45 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 24 365 5.432e-19 5.617e-17
46 CARDIOVASCULAR SYSTEM DEVELOPMENT 32 788 5.823e-19 5.765e-17
47 CIRCULATORY SYSTEM DEVELOPMENT 32 788 5.823e-19 5.765e-17
48 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 45 1784 9.311e-19 9.026e-17
49 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 35 1004 1.143e-18 1.085e-16
50 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 40 1395 1.929e-18 1.795e-16
51 EMBRYO DEVELOPMENT 33 894 2.576e-18 2.351e-16
52 EMBRYONIC MORPHOGENESIS 27 539 2.776e-18 2.484e-16
53 NEURON DIFFERENTIATION 32 874 1.196e-17 1.05e-15
54 REGULATION OF PROTEIN LOCALIZATION 33 950 1.575e-17 1.357e-15
55 NEUROGENESIS 39 1402 1.677e-17 1.419e-15
56 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 33 957 1.958e-17 1.627e-15
57 FC EPSILON RECEPTOR SIGNALING PATHWAY 16 142 1.254e-16 1.024e-14
58 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 21 323 1.362e-16 1.092e-14
59 HEART DEVELOPMENT 24 466 1.452e-16 1.145e-14
60 PATTERN SPECIFICATION PROCESS 23 418 1.609e-16 1.248e-14
61 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 337 3.205e-16 2.445e-14
62 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 16 152 3.777e-16 2.834e-14
63 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 18 220 4.357e-16 3.218e-14
64 REGULATION OF RESPONSE TO STRESS 38 1468 5.319e-16 3.867e-14
65 REGULATION OF CELL DEATH 38 1472 5.813e-16 4.161e-14
66 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 29 801 7.322e-16 5.162e-14
67 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 42 1848 8.939e-16 6.208e-14
68 REGULATION OF TRANSFERASE ACTIVITY 31 946 9.39e-16 6.426e-14
69 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 15 134 1.312e-15 8.85e-14
70 REGULATION OF CELLULAR RESPONSE TO STRESS 27 691 1.367e-15 9.084e-14
71 POSITIVE REGULATION OF CATALYTIC ACTIVITY 38 1518 1.581e-15 1.036e-13
72 REGULATION OF CELLULAR LOCALIZATION 35 1277 1.945e-15 1.257e-13
73 REGULATION OF BINDING 19 283 2.424e-15 1.545e-13
74 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 21 381 3.727e-15 2.343e-13
75 CELL PROLIFERATION 26 672 6.33e-15 3.927e-13
76 PROTEIN PHOSPHORYLATION 30 944 6.831e-15 4.128e-13
77 NEURAL TUBE FORMATION 13 94 6.803e-15 4.128e-13
78 CELL DEVELOPMENT 36 1426 8.651e-15 5.16e-13
79 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 37 1517 9.572e-15 5.638e-13
80 CELL FATE COMMITMENT 17 227 1.324e-14 7.7e-13
81 REGIONALIZATION 19 311 1.355e-14 7.786e-13
82 REGULATION OF JNK CASCADE 15 159 1.734e-14 9.84e-13
83 TUBE FORMATION 14 129 1.901e-14 1.066e-12
84 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 15 162 2.293e-14 1.27e-12
85 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 16 197 2.353e-14 1.288e-12
86 NEGATIVE REGULATION OF GENE EXPRESSION 36 1493 3.509e-14 1.896e-12
87 REGULATION OF CYTOPLASMIC TRANSPORT 22 481 3.546e-14 1.896e-12
88 FC RECEPTOR SIGNALING PATHWAY 16 206 4.743e-14 2.483e-12
89 POSITIVE REGULATION OF CELL DEATH 24 605 4.749e-14 2.483e-12
90 SENSORY ORGAN DEVELOPMENT 22 493 5.848e-14 3.023e-12
91 REGULATION OF CELL CYCLE PROCESS 23 558 7.749e-14 3.962e-12
92 REGULATION OF INTRACELLULAR TRANSPORT 24 621 8.377e-14 4.237e-12
93 DORSAL VENTRAL AXIS SPECIFICATION 8 20 1.033e-13 5.169e-12
94 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 22 513 1.306e-13 6.466e-12
95 REGULATION OF CELL DEVELOPMENT 27 836 1.364e-13 6.682e-12
96 REGULATION OF PROTEIN IMPORT 15 183 1.4e-13 6.785e-12
97 NEURAL TUBE DEVELOPMENT 14 149 1.441e-13 6.862e-12
98 REGULATION OF PROTEIN TARGETING 18 307 1.445e-13 6.862e-12
99 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 20 406 1.487e-13 6.987e-12
100 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 13 119 1.568e-13 7.295e-12
101 NEGATIVE REGULATION OF CELL PROLIFERATION 24 643 1.779e-13 8.198e-12
102 REGULATION OF KINASE ACTIVITY 26 776 1.808e-13 8.249e-12
103 CELL CYCLE 33 1316 1.892e-13 8.547e-12
104 CELL CYCLE PROCESS 30 1081 2.357e-13 1.055e-11
105 GASTRULATION 14 155 2.497e-13 1.106e-11
106 ANTERIOR POSTERIOR PATTERN SPECIFICATION 15 194 3.303e-13 1.45e-11
107 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 25 740 4.758e-13 2.069e-11
108 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 7 14 5.386e-13 2.299e-11
109 CONVERGENT EXTENSION 7 14 5.386e-13 2.299e-11
110 REGULATION OF CELL MORPHOGENESIS 22 552 5.676e-13 2.401e-11
111 RESPONSE TO OXYGEN CONTAINING COMPOUND 33 1381 7.21e-13 3.022e-11
112 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 39 1977 1.323e-12 5.498e-11
113 NEGATIVE REGULATION OF MOLECULAR FUNCTION 29 1079 1.435e-12 5.907e-11
114 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 15 218 1.808e-12 7.378e-11
115 REGULATION OF TRANSPORT 37 1804 1.948e-12 7.883e-11
116 REGULATION OF STEM CELL DIFFERENTIATION 12 113 1.987e-12 7.97e-11
117 REGULATION OF MITOTIC CELL CYCLE 20 468 2.049e-12 8.149e-11
118 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 18 360 2.147e-12 8.465e-11
119 REGULATION OF MAPK CASCADE 23 660 2.506e-12 9.799e-11
120 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 25 799 2.571e-12 9.969e-11
121 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 26 876 2.859e-12 1.099e-10
122 CELLULAR RESPONSE TO RETINOIC ACID 10 65 3.334e-12 1.272e-10
123 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 12 121 4.531e-12 1.714e-10
124 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 10 67 4.575e-12 1.717e-10
125 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 22 616 4.967e-12 1.849e-10
126 PHOSPHORYLATION 30 1228 6.041e-12 2.223e-10
127 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 27 983 6.068e-12 2.223e-10
128 POSITIVE REGULATION OF CELL CYCLE 17 332 6.357e-12 2.311e-10
129 SENSORY ORGAN MORPHOGENESIS 15 239 6.803e-12 2.454e-10
130 MITOTIC CELL CYCLE 24 766 7.367e-12 2.637e-10
131 REGULATION OF CELLULAR COMPONENT BIOGENESIS 24 767 7.571e-12 2.689e-10
132 REGULATION OF HYDROLASE ACTIVITY 31 1327 7.761e-12 2.736e-10
133 CELL DEATH 27 1001 9.212e-12 3.22e-10
134 REGULATION OF PROTEIN CATABOLIC PROCESS 18 393 9.273e-12 3.22e-10
135 REGULATION OF ORGANELLE ORGANIZATION 29 1178 1.231e-11 4.243e-10
136 CELLULAR RESPONSE TO LIPID 19 457 1.248e-11 4.269e-10
137 EMBRYONIC ORGAN DEVELOPMENT 18 406 1.589e-11 5.397e-10
138 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 12 135 1.676e-11 5.649e-10
139 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 15 258 2.028e-11 6.739e-10
140 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 19 470 2.024e-11 6.739e-10
141 POSITIVE REGULATION OF CELL DEVELOPMENT 19 472 2.178e-11 7.187e-10
142 RESPONSE TO GROWTH FACTOR 19 475 2.428e-11 7.957e-10
143 RESPONSE TO LIPID 25 888 2.522e-11 8.207e-10
144 EPITHELIAL TO MESENCHYMAL TRANSITION 9 56 2.791e-11 9.017e-10
145 REGULATION OF IMMUNE SYSTEM PROCESS 31 1403 3.211e-11 1.03e-09
146 REGULATION OF JUN KINASE ACTIVITY 10 81 3.243e-11 1.033e-09
147 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 23 750 3.316e-11 1.05e-09
148 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 17 370 3.512e-11 1.104e-09
149 PROTEASOMAL PROTEIN CATABOLIC PROCESS 15 271 4.07e-11 1.271e-09
150 NEGATIVE REGULATION OF CELL CYCLE 18 433 4.578e-11 1.42e-09
151 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 14 228 4.793e-11 1.477e-09
152 EMBRYONIC ORGAN MORPHOGENESIS 15 279 6.135e-11 1.878e-09
153 STEM CELL DIFFERENTIATION 13 190 6.373e-11 1.938e-09
154 CELL ACTIVATION 20 568 6.712e-11 2.028e-09
155 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 15 282 7.131e-11 2.141e-09
156 REGULATION OF IMMUNE RESPONSE 24 858 7.723e-11 2.304e-09
157 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 20 573 7.84e-11 2.324e-09
158 REGULATION OF PROTEOLYSIS 22 711 7.979e-11 2.35e-09
159 SEGMENTATION 10 89 8.451e-11 2.473e-09
160 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 19 514 9.346e-11 2.718e-09
161 AXIS SPECIFICATION 10 90 9.463e-11 2.735e-09
162 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 7 26 9.759e-11 2.803e-09
163 BETA CATENIN TCF COMPLEX ASSEMBLY 8 43 1.067e-10 3.046e-09
164 NEGATIVE REGULATION OF CELL DEATH 24 872 1.075e-10 3.051e-09
165 REGULATION OF CATENIN IMPORT INTO NUCLEUS 7 27 1.311e-10 3.698e-09
166 RHYTHMIC PROCESS 15 298 1.546e-10 4.332e-09
167 NEGATIVE REGULATION OF CELL DIFFERENTIATION 20 609 2.294e-10 6.392e-09
168 HEART MORPHOGENESIS 13 212 2.495e-10 6.911e-09
169 POSITIVE REGULATION OF KINASE ACTIVITY 18 482 2.608e-10 7.18e-09
170 DIGESTIVE TRACT MORPHOGENESIS 8 48 2.712e-10 7.422e-09
171 CELLULAR RESPONSE TO ABIOTIC STIMULUS 14 263 3.172e-10 8.631e-09
172 RESPONSE TO DRUG 17 431 3.735e-10 1.01e-08
173 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 8 50 3.822e-10 1.028e-08
174 REGULATION OF CELL CYCLE PHASE TRANSITION 15 321 4.344e-10 1.162e-08
175 FAT CELL DIFFERENTIATION 10 106 4.884e-10 1.299e-08
176 RESPONSE TO ABIOTIC STIMULUS 25 1024 5.073e-10 1.341e-08
177 INOSITOL PHOSPHATE MEDIATED SIGNALING 6 18 5.272e-10 1.386e-08
178 RESPONSE TO RETINOIC ACID 10 107 5.362e-10 1.402e-08
179 SOMITE DEVELOPMENT 9 78 6.053e-10 1.573e-08
180 DEVELOPMENTAL GROWTH 15 333 7.207e-10 1.863e-08
181 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 34 7.687e-10 1.976e-08
182 REGULATION OF CATABOLIC PROCESS 21 731 8.736e-10 2.234e-08
183 MESENCHYME DEVELOPMENT 12 190 9.052e-10 2.302e-08
184 POSITIVE REGULATION OF CELL PROLIFERATION 22 814 1.022e-09 2.585e-08
185 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 14 289 1.085e-09 2.728e-08
186 CELLULAR COMPONENT MORPHOGENESIS 23 900 1.182e-09 2.956e-08
187 VASCULATURE DEVELOPMENT 17 469 1.351e-09 3.361e-08
188 POSITIVE REGULATION OF MAPK CASCADE 17 470 1.395e-09 3.453e-08
189 MIDBRAIN DEVELOPMENT 9 90 2.214e-09 5.452e-08
190 REGULATION OF CELLULAR COMPONENT MOVEMENT 21 771 2.261e-09 5.537e-08
191 SOMITOGENESIS 8 62 2.274e-09 5.54e-08
192 DORSAL VENTRAL PATTERN FORMATION 9 91 2.446e-09 5.927e-08
193 POSITIVE REGULATION OF JUN KINASE ACTIVITY 8 63 2.593e-09 6.251e-08
194 REGULATION OF GROWTH 19 633 3.008e-09 7.214e-08
195 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 3.027e-09 7.224e-08
196 HEAD DEVELOPMENT 20 709 3.17e-09 7.526e-08
197 REGULATION OF PROTEIN BINDING 11 168 3.224e-09 7.616e-08
198 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 13 263 3.481e-09 8.18e-08
199 NEGATIVE REGULATION OF BINDING 10 131 3.928e-09 9.184e-08
200 CELLULAR RESPONSE TO ACID CHEMICAL 11 175 4.954e-09 1.153e-07
201 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 13 274 5.698e-09 1.319e-07
202 REGULATION OF CELL GROWTH 15 391 6.401e-09 1.475e-07
203 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 11 181 7.053e-09 1.617e-07
204 PEPTIDYL THREONINE MODIFICATION 7 46 7.23e-09 1.649e-07
205 RESPONSE TO ENDOGENOUS STIMULUS 28 1450 7.36e-09 1.671e-07
206 MACROMOLECULAR COMPLEX DISASSEMBLY 11 182 7.471e-09 1.687e-07
207 REGULATION OF EPITHELIAL CELL PROLIFERATION 13 285 9.126e-09 2.051e-07
208 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 9 106 9.545e-09 2.135e-07
209 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 10 144 9.826e-09 2.188e-07
210 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 15 404 9.923e-09 2.199e-07
211 DOPAMINERGIC NEURON DIFFERENTIATION 6 28 1.021e-08 2.253e-07
212 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 19 684 1.057e-08 2.32e-07
213 REPRODUCTIVE SYSTEM DEVELOPMENT 15 408 1.132e-08 2.473e-07
214 GROWTH 15 410 1.208e-08 2.627e-07
215 DIGESTIVE SYSTEM DEVELOPMENT 10 148 1.279e-08 2.769e-07
216 POSITIVE REGULATION OF TRANSPORT 22 936 1.314e-08 2.83e-07
217 REGULATION OF OSTEOBLAST DIFFERENTIATION 9 112 1.552e-08 3.329e-07
218 NEGATIVE REGULATION OF PROTEIN BINDING 8 79 1.62e-08 3.457e-07
219 POSITIVE REGULATION OF CELL CYCLE PROCESS 12 247 1.749e-08 3.717e-07
220 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 11 199 1.891e-08 3.999e-07
221 POSITIVE REGULATION OF PROTEOLYSIS 14 363 1.989e-08 4.187e-07
222 PROTEIN COMPLEX SUBUNIT ORGANIZATION 28 1527 2.257e-08 4.73e-07
223 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 117 2.279e-08 4.755e-07
224 CELL CYCLE PHASE TRANSITION 12 255 2.491e-08 5.174e-07
225 OUTFLOW TRACT MORPHOGENESIS 7 56 2.989e-08 6.181e-07
226 REGULATION OF CHROMATIN BINDING 5 17 3.227e-08 6.644e-07
227 REGULATION OF MAP KINASE ACTIVITY 13 319 3.466e-08 7.104e-07
228 CELLULAR RESPONSE TO EXTERNAL STIMULUS 12 264 3.652e-08 7.452e-07
229 CELLULAR COMPONENT DISASSEMBLY 16 515 3.744e-08 7.606e-07
230 CELLULAR RESPONSE TO STRESS 28 1565 3.816e-08 7.721e-07
231 EMBRYONIC PATTERN SPECIFICATION 7 58 3.839e-08 7.733e-07
232 EYE DEVELOPMENT 13 326 4.47e-08 8.964e-07
233 CALCIUM MEDIATED SIGNALING 8 90 4.569e-08 9.084e-07
234 MESONEPHROS DEVELOPMENT 8 90 4.569e-08 9.084e-07
235 NEGATIVE REGULATION OF CELL GROWTH 10 170 4.801e-08 9.466e-07
236 SKELETAL SYSTEM DEVELOPMENT 15 455 4.784e-08 9.466e-07
237 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 22 1008 4.912e-08 9.644e-07
238 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 171 5.075e-08 9.922e-07
239 REGULATION OF PROTEIN STABILITY 11 221 5.553e-08 1.081e-06
240 REGULATION OF CELL SUBSTRATE ADHESION 10 173 5.665e-08 1.098e-06
241 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 9 131 6.104e-08 1.179e-06
242 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 15 465 6.356e-08 1.221e-06
243 LOCOMOTION 23 1114 6.374e-08 1.221e-06
244 REGULATION OF CHROMOSOME ORGANIZATION 12 278 6.436e-08 1.227e-06
245 REGULATION OF MUSCLE ADAPTATION 7 63 6.901e-08 1.311e-06
246 WOUND HEALING 15 470 7.306e-08 1.382e-06
247 MESENCHYMAL CELL DIFFERENTIATION 9 134 7.426e-08 1.399e-06
248 CENTRAL NERVOUS SYSTEM DEVELOPMENT 20 872 9.858e-08 1.85e-06
249 COCHLEA MORPHOGENESIS 5 21 1.042e-07 1.947e-06
250 NEGATIVE REGULATION OF GROWTH 11 236 1.083e-07 2.015e-06
251 REGULATION OF CELL JUNCTION ASSEMBLY 7 68 1.181e-07 2.181e-06
252 POSITIVE REGULATION OF GROWTH 11 238 1.179e-07 2.181e-06
253 RESPONSE TO WOUNDING 16 563 1.269e-07 2.334e-06
254 IMMUNE SYSTEM PROCESS 31 1984 1.311e-07 2.401e-06
255 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 103 1.318e-07 2.405e-06
256 POSITIVE REGULATION OF PROTEIN IMPORT 8 104 1.421e-07 2.583e-06
257 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 724 1.429e-07 2.587e-06
258 MORPHOGENESIS OF AN EPITHELIAL SHEET 6 43 1.542e-07 2.781e-06
259 REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 363 1.556e-07 2.795e-06
260 MUSCLE STRUCTURE DEVELOPMENT 14 432 1.71e-07 3.048e-06
261 SCF DEPENDENT PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 5 23 1.708e-07 3.048e-06
262 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 9 148 1.745e-07 3.088e-06
263 PEPTIDYL SERINE MODIFICATION 9 148 1.745e-07 3.088e-06
264 POSITIVE REGULATION OF HYDROLASE ACTIVITY 20 905 1.793e-07 3.16e-06
265 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 22 1087 1.828e-07 3.21e-06
266 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 10 197 1.915e-07 3.35e-06
267 FORMATION OF PRIMARY GERM LAYER 8 110 2.197e-07 3.829e-06
268 RESPONSE TO ORGANIC CYCLIC COMPOUND 20 917 2.213e-07 3.843e-06
269 LEUKOCYTE CELL CELL ADHESION 11 255 2.36e-07 4.083e-06
270 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 9 154 2.45e-07 4.222e-06
271 REGULATION OF CELLULAR RESPONSE TO HEAT 7 76 2.566e-07 4.405e-06
272 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 7 77 2.809e-07 4.805e-06
273 RESPONSE TO ACID CHEMICAL 12 319 2.849e-07 4.856e-06
274 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 16 602 3.128e-07 5.312e-06
275 CELL CELL SIGNALING 18 767 3.342e-07 5.655e-06
276 SECOND MESSENGER MEDIATED SIGNALING 9 160 3.39e-07 5.715e-06
277 SINGLE ORGANISM CELL ADHESION 14 459 3.561e-07 5.981e-06
278 MESODERM DEVELOPMENT 8 118 3.778e-07 6.323e-06
279 DEVELOPMENTAL INDUCTION 5 27 4.023e-07 6.685e-06
280 AXIS ELONGATION 5 27 4.023e-07 6.685e-06
281 POSITIVE REGULATION OF CATABOLIC PROCESS 13 395 4.082e-07 6.76e-06
282 APPENDAGE DEVELOPMENT 9 169 5.382e-07 8.849e-06
283 LIMB DEVELOPMENT 9 169 5.382e-07 8.849e-06
284 PALATE DEVELOPMENT 7 85 5.554e-07 9.099e-06
285 REGULATION OF CELL ADHESION 16 629 5.608e-07 9.155e-06
286 KIDNEY EPITHELIUM DEVELOPMENT 8 125 5.877e-07 9.562e-06
287 RESPONSE TO CYTOKINE 17 714 6.025e-07 9.768e-06
288 RESPONSE TO UV 8 126 6.246e-07 1.009e-05
289 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 4 13 6.88e-07 1.108e-05
290 REGULATION OF STEM CELL PROLIFERATION 7 88 7.043e-07 1.13e-05
291 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 129 7.474e-07 1.195e-05
292 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 10 229 7.661e-07 1.221e-05
293 APOPTOTIC SIGNALING PATHWAY 11 289 8.168e-07 1.297e-05
294 REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 5 31 8.315e-07 1.312e-05
295 REGULATION OF OSSIFICATION 9 178 8.319e-07 1.312e-05
296 RESPONSE TO EXTERNAL STIMULUS 28 1821 8.736e-07 1.373e-05
297 EPITHELIAL CELL DIFFERENTIATION 14 495 8.772e-07 1.374e-05
298 INNER EAR MORPHOGENESIS 7 92 9.539e-07 1.489e-05
299 PROTEIN CATABOLIC PROCESS 15 579 1.042e-06 1.621e-05
300 RESPONSE TO ALCOHOL 12 362 1.087e-06 1.685e-05
301 EYE MORPHOGENESIS 8 136 1.117e-06 1.726e-05
302 UROGENITAL SYSTEM DEVELOPMENT 11 299 1.14e-06 1.756e-05
303 EMBRYONIC AXIS SPECIFICATION 5 33 1.151e-06 1.762e-05
304 BLOOD VESSEL MORPHOGENESIS 12 364 1.151e-06 1.762e-05
305 CHONDROCYTE DIFFERENTIATION 6 60 1.17e-06 1.78e-05
306 REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 6 60 1.17e-06 1.78e-05
307 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 95 1.186e-06 1.787e-05
308 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 7 95 1.186e-06 1.787e-05
309 CELLULAR RESPONSE TO RADIATION 8 137 1.18e-06 1.787e-05
310 EMBRYONIC DIGIT MORPHOGENESIS 6 61 1.292e-06 1.939e-05
311 MITOTIC CELL CYCLE CHECKPOINT 8 139 1.317e-06 1.97e-05
312 REGULATION OF PROTEIN DEACETYLATION 5 34 1.343e-06 1.99e-05
313 REGULATION OF MESENCHYMAL CELL PROLIFERATION 5 34 1.343e-06 1.99e-05
314 PROTEIN DESTABILIZATION 5 34 1.343e-06 1.99e-05
315 REGULATION OF SMOOTHENED SIGNALING PATHWAY 6 62 1.424e-06 2.103e-05
316 PROTEIN DEPHOSPHORYLATION 9 190 1.433e-06 2.11e-05
317 REGULATION OF EPIDERMIS DEVELOPMENT 6 63 1.567e-06 2.299e-05
318 IN UTERO EMBRYONIC DEVELOPMENT 11 311 1.672e-06 2.447e-05
319 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 7 100 1.679e-06 2.449e-05
320 RESPONSE TO NITROGEN COMPOUND 18 859 1.706e-06 2.473e-05
321 CONNECTIVE TISSUE DEVELOPMENT 9 194 1.703e-06 2.473e-05
322 REGULATION OF ACTIN FILAMENT BASED PROCESS 11 312 1.725e-06 2.49e-05
323 PARAXIAL MESODERM DEVELOPMENT 4 16 1.728e-06 2.49e-05
324 CAMERA TYPE EYE MORPHOGENESIS 7 101 1.796e-06 2.579e-05
325 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 36 1.803e-06 2.582e-05
326 RESPIRATORY SYSTEM DEVELOPMENT 9 197 1.933e-06 2.759e-05
327 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 18 867 1.945e-06 2.768e-05
328 CELLULAR RESPONSE TO UV 6 66 2.066e-06 2.887e-05
329 REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 103 2.049e-06 2.887e-05
330 REGULATION OF CIRCADIAN RHYTHM 7 103 2.049e-06 2.887e-05
331 MESODERM MORPHOGENESIS 6 66 2.066e-06 2.887e-05
332 REGULATION OF MUSCLE ORGAN DEVELOPMENT 7 103 2.049e-06 2.887e-05
333 LENS DEVELOPMENT IN CAMERA TYPE EYE 6 66 2.066e-06 2.887e-05
334 NEGATIVE REGULATION OF TRANSPORT 13 458 2.132e-06 2.97e-05
335 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 7 104 2.187e-06 3.037e-05
336 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 17 2.25e-06 3.098e-05
337 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 4 17 2.25e-06 3.098e-05
338 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 15 616 2.24e-06 3.098e-05
339 SKELETAL SYSTEM MORPHOGENESIS 9 201 2.281e-06 3.131e-05
340 MESENCHYME MORPHOGENESIS 5 38 2.379e-06 3.256e-05
341 REGULATION OF FAT CELL DIFFERENTIATION 7 106 2.485e-06 3.374e-05
342 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 541 2.487e-06 3.374e-05
343 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 541 2.487e-06 3.374e-05
344 ACTIVATION OF INNATE IMMUNE RESPONSE 9 204 2.577e-06 3.485e-05
345 GLAND DEVELOPMENT 12 395 2.688e-06 3.625e-05
346 NEURON PROJECTION DEVELOPMENT 14 545 2.709e-06 3.643e-05
347 COCHLEA DEVELOPMENT 5 39 2.717e-06 3.643e-05
348 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 7 108 2.817e-06 3.767e-05
349 POSITIVE REGULATION OF MAP KINASE ACTIVITY 9 207 2.905e-06 3.873e-05
350 REGULATION OF MEMBRANE PERMEABILITY 6 70 2.927e-06 3.891e-05
351 RESPONSE TO HORMONE 18 893 2.946e-06 3.905e-05
352 POSITIVE REGULATION OF CELL MATRIX ADHESION 5 40 3.091e-06 4.086e-05
353 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 9 209 3.143e-06 4.143e-05
354 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 71 3.182e-06 4.183e-05
355 REGULATION OF NEURON DIFFERENTIATION 14 554 3.274e-06 4.291e-05
356 RESPONSE TO INORGANIC SUBSTANCE 13 479 3.482e-06 4.552e-05
357 REPRODUCTION 22 1297 3.5e-06 4.562e-05
358 EAR MORPHOGENESIS 7 112 3.592e-06 4.669e-05
359 POSITIVE REGULATION OF PROTEIN EXPORT FROM NUCLEUS 4 19 3.633e-06 4.708e-05
360 LYMPHOCYTE ACTIVATION 11 342 4.172e-06 5.393e-05
361 RESPONSE TO RADIATION 12 413 4.244e-06 5.47e-05
362 LEUKOCYTE ACTIVATION 12 414 4.35e-06 5.591e-05
363 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 5 43 4.461e-06 5.702e-05
364 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 43 4.461e-06 5.702e-05
365 POSITIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 4 20 4.521e-06 5.763e-05
366 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 17 829 4.565e-06 5.803e-05
367 POSITIVE REGULATION OF LOCOMOTION 12 420 5.036e-06 6.385e-05
368 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 8 167 5.188e-06 6.56e-05
369 CHROMATIN ORGANIZATION 15 663 5.47e-06 6.898e-05
370 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 4 21 5.56e-06 6.992e-05
371 PROTEIN COMPLEX BIOGENESIS 20 1132 5.722e-06 7.157e-05
372 PROTEIN COMPLEX ASSEMBLY 20 1132 5.722e-06 7.157e-05
373 REGULATION OF CYTOSKELETON ORGANIZATION 13 502 5.789e-06 7.221e-05
374 ACTIVATION OF IMMUNE RESPONSE 12 427 5.956e-06 7.41e-05
375 REGULATION OF DEVELOPMENTAL GROWTH 10 289 6.159e-06 7.641e-05
376 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 7 122 6.339e-06 7.844e-05
377 SOMATIC STEM CELL DIVISION 4 22 6.766e-06 8.35e-05
378 REGULATION OF FIBROBLAST PROLIFERATION 6 81 6.885e-06 8.475e-05
379 ANGIOGENESIS 10 293 6.948e-06 8.53e-05
380 KIDNEY MORPHOGENESIS 6 82 7.394e-06 9.054e-05
381 ANTERIOR POSTERIOR AXIS SPECIFICATION 5 48 7.757e-06 9.449e-05
382 POSITIVE REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 5 48 7.757e-06 9.449e-05
383 RESPONSE TO EXTRACELLULAR STIMULUS 12 441 8.249e-06 0.0001002
384 REGULATION OF PHOSPHATASE ACTIVITY 7 128 8.698e-06 0.0001051
385 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 7 128 8.698e-06 0.0001051
386 MUSCLE CELL DIFFERENTIATION 9 237 8.716e-06 0.0001051
387 NEGATIVE REGULATION OF CELL DEVELOPMENT 10 303 9.317e-06 0.0001117
388 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 10 303 9.317e-06 0.0001117
389 REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 50 9.512e-06 0.0001138
390 REGULATION OF HISTONE DEACETYLATION 4 24 9.742e-06 0.0001153
391 POSITIVE REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 4 24 9.742e-06 0.0001153
392 POSITIVE REGULATION OF CELL JUNCTION ASSEMBLY 4 24 9.742e-06 0.0001153
393 REGULATION OF PROTEIN PHOSPHATASE TYPE 2A ACTIVITY 4 24 9.742e-06 0.0001153
394 REGULATION OF PROTEIN COMPLEX ASSEMBLY 11 375 9.969e-06 0.0001177
395 PROTEIN STABILIZATION 7 131 1.013e-05 0.0001193
396 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 5 51 1.05e-05 0.000123
397 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 5 51 1.05e-05 0.000123
398 MAINTENANCE OF CELL NUMBER 7 132 1.064e-05 0.0001244
399 RESPONSE TO OXYGEN LEVELS 10 311 1.169e-05 0.0001363
400 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 9 246 1.175e-05 0.0001367
401 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 135 1.233e-05 0.000143
402 CHROMATIN MODIFICATION 13 539 1.237e-05 0.0001432
403 REGULATION OF CELL MATRIX ADHESION 6 90 1.267e-05 0.0001463
404 MESONEPHRIC TUBULE MORPHOGENESIS 5 53 1.271e-05 0.0001464
405 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 8 190 1.335e-05 0.0001533
406 CELLULAR RESPONSE TO LIGHT STIMULUS 6 91 1.35e-05 0.0001547
407 CELL PROJECTION ORGANIZATION 17 902 1.377e-05 0.0001574
408 CELL CYCLE G2 M PHASE TRANSITION 7 138 1.423e-05 0.0001623
409 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 8 192 1.44e-05 0.000163
410 MITOCHONDRIAL MEMBRANE ORGANIZATION 6 92 1.438e-05 0.000163
411 PROTEIN AUTOPHOSPHORYLATION 8 192 1.44e-05 0.000163
412 PROTEOLYSIS 20 1208 1.487e-05 0.000168
413 CELL CYCLE CHECKPOINT 8 194 1.552e-05 0.0001749
414 CHROMOSOME ORGANIZATION 18 1009 1.57e-05 0.0001765
415 RESPONSE TO LITHIUM ION 4 27 1.588e-05 0.000178
416 REGULATION OF MUSCLE SYSTEM PROCESS 8 195 1.611e-05 0.0001802
417 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 95 1.728e-05 0.0001929
418 REGULATION OF CELL PROJECTION ORGANIZATION 13 558 1.783e-05 0.0001985
419 CARDIAC CHAMBER DEVELOPMENT 7 144 1.876e-05 0.0002083
420 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 262 1.938e-05 0.0002147
421 REGULATION OF CYTOKINE PRODUCTION 13 563 1.958e-05 0.0002158
422 POSITIVE REGULATION OF IMMUNE RESPONSE 13 563 1.958e-05 0.0002158
423 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 7 146 2.051e-05 0.0002256
424 RESPONSE TO METAL ION 10 333 2.106e-05 0.0002311
425 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 2.13e-05 0.0002316
426 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 2.13e-05 0.0002316
427 STEM CELL DIVISION 4 29 2.13e-05 0.0002316
428 BIOLOGICAL ADHESION 18 1032 2.121e-05 0.0002316
429 CARTILAGE DEVELOPMENT 7 147 2.143e-05 0.0002319
430 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 7 147 2.143e-05 0.0002319
431 SEX DIFFERENTIATION 9 266 2.184e-05 0.0002356
432 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 6 99 2.188e-05 0.0002356
433 POSITIVE REGULATION OF CELL GROWTH 7 148 2.239e-05 0.0002406
434 STEM CELL PROLIFERATION 5 60 2.343e-05 0.0002512
435 PROTEIN LOCALIZATION 25 1805 2.369e-05 0.0002534
436 RESPONSE TO X RAY 4 30 2.447e-05 0.0002612
437 REGULATION OF CHROMATIN ORGANIZATION 7 152 2.659e-05 0.0002831
438 RESPONSE TO MECHANICAL STIMULUS 8 210 2.744e-05 0.0002916
439 IMMUNE SYSTEM DEVELOPMENT 13 582 2.766e-05 0.0002932
440 COVALENT CHROMATIN MODIFICATION 10 345 2.848e-05 0.0003012
441 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 11 2.879e-05 0.0003037
442 CARDIAC CHAMBER MORPHOGENESIS 6 104 2.895e-05 0.000304
443 CELL CYCLE ARREST 7 154 2.892e-05 0.000304
444 REGULATION OF CARTILAGE DEVELOPMENT 5 63 2.975e-05 0.0003111
445 NEGATIVE REGULATION OF PHOSPHORYLATION 11 422 2.972e-05 0.0003111
446 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 8 213 3.037e-05 0.0003168
447 NEGATIVE REGULATION OF CELL CYCLE PROCESS 8 214 3.14e-05 0.0003263
448 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 7 156 3.142e-05 0.0003263
449 CELLULAR RESPONSE TO NITROGEN COMPOUND 12 505 3.155e-05 0.0003269
450 PATTERNING OF BLOOD VESSELS 4 32 3.183e-05 0.0003284
451 EMBRYONIC FORELIMB MORPHOGENESIS 4 32 3.183e-05 0.0003284
452 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 20 1275 3.226e-05 0.000332
453 RESPONSE TO LIGHT STIMULUS 9 280 3.266e-05 0.0003355
454 REGULATION OF DEPHOSPHORYLATION 7 158 3.409e-05 0.0003494
455 REGULATION OF MITOCHONDRION ORGANIZATION 8 218 3.583e-05 0.0003657
456 REGULATION OF CELL CYCLE ARREST 6 108 3.584e-05 0.0003657
457 REGULATION OF PROTEIN EXPORT FROM NUCLEUS 4 33 3.606e-05 0.0003664
458 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 4 33 3.606e-05 0.0003664
459 NEURON DEVELOPMENT 14 687 3.66e-05 0.000371
460 SOMATIC STEM CELL POPULATION MAINTENANCE 5 66 3.731e-05 0.0003774
461 MACROMOLECULAR COMPLEX ASSEMBLY 21 1398 3.76e-05 0.0003795
462 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 3 12 3.822e-05 0.0003841
463 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 3 12 3.822e-05 0.0003841
464 DEPHOSPHORYLATION 9 286 3.853e-05 0.0003864
465 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 5 67 4.014e-05 4e-04
466 CELLULAR RESPONSE TO DRUG 5 67 4.014e-05 4e-04
467 REGULATION OF SISTER CHROMATID SEGREGATION 5 67 4.014e-05 4e-04
468 BRAIN MORPHOGENESIS 4 34 4.069e-05 0.0004045
469 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 11 437 4.083e-05 0.000405
470 CELL CYCLE G1 S PHASE TRANSITION 6 111 4.182e-05 0.0004132
471 G1 S TRANSITION OF MITOTIC CELL CYCLE 6 111 4.182e-05 0.0004132
472 CELL CELL ADHESION 13 608 4.341e-05 0.0004279
473 BONE REMODELING 4 35 4.574e-05 0.0004499
474 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 7 166 4.671e-05 0.0004585
475 WHITE FAT CELL DIFFERENTIATION 3 13 4.948e-05 0.0004807
476 HEMATOPOIETIC STEM CELL PROLIFERATION 3 13 4.948e-05 0.0004807
477 REGULATION OF SKELETAL MUSCLE ADAPTATION 3 13 4.948e-05 0.0004807
478 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 10 368 4.91e-05 0.0004807
479 REGULATION OF CELL FATE SPECIFICATION 3 13 4.948e-05 0.0004807
480 NEURAL PRECURSOR CELL PROLIFERATION 5 70 4.963e-05 0.0004811
481 RESPONSE TO CARBOHYDRATE 7 168 5.04e-05 0.0004876
482 CELLULAR RESPONSE TO ALCOHOL 6 115 5.102e-05 0.0004915
483 NEPHRON DEVELOPMENT 6 115 5.102e-05 0.0004915
484 POSITIVE REGULATION OF CYTOKINE PRODUCTION 10 370 5.138e-05 0.000494
485 ENDODERM DEVELOPMENT 5 71 5.315e-05 0.0005099
486 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 6 117 5.619e-05 0.000538
487 REGULATION OF MUSCLE HYPERTROPHY 4 37 5.719e-05 0.0005464
488 REGULATION OF VASCULATURE DEVELOPMENT 8 233 5.734e-05 0.0005467
489 POSITIVE REGULATION OF CELL ADHESION 10 376 5.877e-05 0.0005593
490 REGULATION OF MONOCYTE DIFFERENTIATION 3 14 6.272e-05 0.0005955
491 CELL DIVISION 11 460 6.476e-05 0.0006137
492 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 7 175 6.525e-05 0.0006171
493 MITOCHONDRIAL TRANSPORT 7 177 7.01e-05 0.0006602
494 TAXIS 11 464 6.997e-05 0.0006602
495 MACROMOLECULE CATABOLIC PROCESS 16 926 7.144e-05 0.0006715
496 CELLULAR RESPONSE TO HORMONE STIMULUS 12 552 7.424e-05 0.0006953
497 T CELL DIFFERENTIATION 6 123 7.427e-05 0.0006953
498 NEGATIVE REGULATION OF DENDRITE MORPHOGENESIS 3 15 7.807e-05 0.0007268
499 FORELIMB MORPHOGENESIS 4 40 7.81e-05 0.0007268
500 REGULATION OF MESODERM DEVELOPMENT 3 15 7.807e-05 0.0007268
501 REGULATION OF BMP SIGNALING PATHWAY 5 77 7.849e-05 0.000729
502 CELL MOTILITY 15 835 7.962e-05 0.0007366
503 LOCALIZATION OF CELL 15 835 7.962e-05 0.0007366
504 RENAL TUBULE DEVELOPMENT 5 78 8.349e-05 0.0007708
505 OSTEOBLAST DIFFERENTIATION 6 126 8.49e-05 0.0007807
506 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 126 8.49e-05 0.0007807
507 PEPTIDYL AMINO ACID MODIFICATION 15 841 8.624e-05 0.0007915
508 REGULATION OF MYELOID CELL DIFFERENTIATION 7 183 8.642e-05 0.0007916
509 HEPATICOBILIARY SYSTEM DEVELOPMENT 6 128 9.263e-05 0.0008435
510 CELL JUNCTION ORGANIZATION 7 185 9.25e-05 0.0008435
511 MUSCLE CELL DEVELOPMENT 6 128 9.263e-05 0.0008435
512 NEGATIVE REGULATION OF KINASE ACTIVITY 8 250 9.376e-05 0.0008521
513 CELLULAR RESPONSE TO MECHANICAL STIMULUS 5 80 9.421e-05 0.0008545
514 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 9.569e-05 0.0008645
515 ORGAN INDUCTION 3 16 9.569e-05 0.0008645
516 OSSIFICATION 8 251 9.639e-05 0.0008692
517 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 7 188 0.0001023 0.0009188
518 NEURON PROJECTION MORPHOGENESIS 10 402 0.0001022 0.0009188
519 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 4 43 0.0001041 0.0009314
520 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 4 43 0.0001041 0.0009314
521 REGULATION OF PEPTIDE TRANSPORT 8 256 0.0001105 0.0009868
522 NIK NF KAPPAB SIGNALING 5 83 0.0001123 0.001001
523 LABYRINTHINE LAYER DEVELOPMENT 4 44 0.000114 0.001012
524 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 4 44 0.000114 0.001012
525 CELLULAR RESPONSE TO LITHIUM ION 3 17 0.0001157 0.001022
526 ESTABLISHMENT OF TISSUE POLARITY 3 17 0.0001157 0.001022
527 REGULATION OF NEURON PROJECTION DEVELOPMENT 10 408 0.0001154 0.001022
528 POSITIVE REGULATION OF OSSIFICATION 5 84 0.0001188 0.001047
529 REGULATION OF GTPASE ACTIVITY 13 673 0.0001209 0.001063
530 THYMOCYTE AGGREGATION 4 45 0.0001246 0.001092
531 T CELL DIFFERENTIATION IN THYMUS 4 45 0.0001246 0.001092
532 CARDIAC SEPTUM DEVELOPMENT 5 85 0.0001257 0.001093
533 REGULATION OF CHROMOSOME SEGREGATION 5 85 0.0001257 0.001093
534 POSITIVE REGULATION OF CHROMATIN MODIFICATION 5 85 0.0001257 0.001093
535 POSITIVE REGULATION OF CELL CYCLE ARREST 5 85 0.0001257 0.001093
536 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 7 195 0.0001284 0.001113
537 EAR DEVELOPMENT 7 195 0.0001284 0.001113
538 NEGATIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 6 136 0.0001294 0.001119
539 NEGATIVE REGULATION OF LOCOMOTION 8 263 0.0001331 0.001149
540 REGULATION OF CHONDROCYTE DIFFERENTIATION 4 46 0.0001358 0.00117
541 REGULATION OF CELL MATURATION 3 18 0.0001383 0.001181
542 G PROTEIN COUPLED RECEPTOR SIGNALING PATHWAY 18 1193 0.0001377 0.001181
543 PERICARDIUM DEVELOPMENT 3 18 0.0001383 0.001181
544 POST ANAL TAIL MORPHOGENESIS 3 18 0.0001383 0.001181
545 SIGNAL TRANSDUCTION INVOLVED IN REGULATION OF GENE EXPRESSION 3 18 0.0001383 0.001181
546 PLACENTA DEVELOPMENT 6 138 0.0001401 0.001194
547 REGULATION OF DNA METABOLIC PROCESS 9 340 0.0001445 0.001229
548 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 88 0.0001481 0.001255
549 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 47 0.0001478 0.001255
550 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 6 141 0.0001576 0.001334
551 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 19 0.0001635 0.001381
552 PLATELET ACTIVATION 6 142 0.0001638 0.001381
553 ENDOTHELIUM DEVELOPMENT 5 90 0.0001646 0.001385
554 REGULATION OF CELL DIVISION 8 272 0.0001676 0.001407
555 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 0.0001702 0.001422
556 RAS PROTEIN SIGNAL TRANSDUCTION 6 143 0.0001702 0.001422
557 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 6 143 0.0001702 0.001422
558 CARDIAC SEPTUM MORPHOGENESIS 4 49 0.0001741 0.001451
559 NEURON PROJECTION GUIDANCE 7 205 0.0001749 0.001455
560 MEMBRANE ORGANIZATION 15 899 0.0001795 0.001492
561 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 9 351 0.0001833 0.00152
562 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 9 352 0.0001872 0.00155
563 POSITIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 50 0.0001884 0.001554
564 RHO PROTEIN SIGNAL TRANSDUCTION 4 50 0.0001884 0.001554
565 TONGUE DEVELOPMENT 3 20 0.0001916 0.001573
566 NEPHRON EPITHELIUM DEVELOPMENT 5 93 0.0001921 0.001573
567 REGULATION OF DNA BINDING 5 93 0.0001921 0.001573
568 TRACHEA DEVELOPMENT 3 20 0.0001916 0.001573
569 LYMPHOCYTE DIFFERENTIATION 7 209 0.0001969 0.00161
570 MALE SEX DIFFERENTIATION 6 148 0.0002052 0.001675
571 REGULATION OF INNATE IMMUNE RESPONSE 9 357 0.0002079 0.001691
572 FOREBRAIN DEVELOPMENT 9 357 0.0002079 0.001691
573 SKIN DEVELOPMENT 7 211 0.0002087 0.001695
574 BONE RESORPTION 3 21 0.0002226 0.001804
575 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 4 53 0.0002364 0.001908
576 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 0.0002364 0.001908
577 REGULATION OF MUSCLE CELL DIFFERENTIATION 6 152 0.000237 0.001908
578 INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 152 0.000237 0.001908
579 POSITIVE REGULATION OF DEFENSE RESPONSE 9 364 0.0002401 0.001929
580 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 5 98 0.0002454 0.001967
581 PALLIUM DEVELOPMENT 6 153 0.0002456 0.001967
582 MODULATION OF TRANSCRIPTION IN OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 3 22 0.0002567 0.002041
583 POSITIVE REGULATION OF MUSCLE HYPERTROPHY 3 22 0.0002567 0.002041
584 POSITIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY 3 22 0.0002567 0.002041
585 REGULATION OF STRIATED MUSCLE CELL APOPTOTIC PROCESS 3 22 0.0002567 0.002041
586 LEUKOCYTE DIFFERENTIATION 8 292 0.000271 0.002152
587 SMAD PROTEIN SIGNAL TRANSDUCTION 4 56 0.0002926 0.00232
588 NEGATIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 3 23 0.0002939 0.002322
589 REGULATION OF OSTEOBLAST PROLIFERATION 3 23 0.0002939 0.002322
590 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 102 0.0002955 0.002331
591 MYOTUBE DIFFERENTIATION 4 57 0.0003133 0.002463
592 APOPTOTIC MITOCHONDRIAL CHANGES 4 57 0.0003133 0.002463
593 REGENERATION 6 161 0.000323 0.00253
594 REGULATION OF DNA REPLICATION 6 161 0.000323 0.00253
595 MODULATION OF SYNAPTIC TRANSMISSION 8 301 0.0003322 0.002598
596 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 3 24 0.0003345 0.002612
597 CEREBRAL CORTEX DEVELOPMENT 5 105 0.000338 0.002635
598 CELLULAR RESPONSE TO BIOTIC STIMULUS 6 163 0.0003451 0.002685
599 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 4 59 0.0003579 0.002775
600 VASCULOGENESIS 4 59 0.0003579 0.002775
601 REGULATION OF LEUKOCYTE DIFFERENTIATION 7 232 0.0003711 0.002868
602 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 7 232 0.0003711 0.002868
603 LENS FIBER CELL DIFFERENTIATION 3 25 0.0003786 0.002907
604 SPINDLE CHECKPOINT 3 25 0.0003786 0.002907
605 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 3 25 0.0003786 0.002907
606 NEGATIVE REGULATION OF SMOOTHENED SIGNALING PATHWAY 3 25 0.0003786 0.002907
607 NEGATIVE REGULATION OF CELL DIVISION 4 60 0.0003818 0.002917
608 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 7 233 0.0003808 0.002917
609 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 4 60 0.0003818 0.002917
610 CATABOLIC PROCESS 22 1773 0.0003867 0.00295
611 INTERSPECIES INTERACTION BETWEEN ORGANISMS 12 662 0.0003975 0.003022
612 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 12 662 0.0003975 0.003022
613 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 5 109 0.0004017 0.003044
614 RESPONSE TO HYDROGEN PEROXIDE 5 109 0.0004017 0.003044
615 POSITIVE REGULATION OF STEM CELL PROLIFERATION 4 61 0.0004068 0.003078
616 REGULATION OF HORMONE LEVELS 10 478 0.0004102 0.003098
617 HEMOSTASIS 8 311 0.000413 0.003114
618 SYSTEM PROCESS 22 1785 0.0004243 0.003195
619 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 3 26 0.0004262 0.003198
620 REGULATION OF CELL FATE COMMITMENT 3 26 0.0004262 0.003198
621 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 9 397 0.0004524 0.00339
622 STRIATED MUSCLE CELL DIFFERENTIATION 6 173 0.0004736 0.003543
623 SKELETAL MUSCLE TISSUE REGENERATION 3 27 0.0004775 0.003549
624 REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 3 27 0.0004775 0.003549
625 NEGATIVE REGULATION OF FIBROBLAST PROLIFERATION 3 27 0.0004775 0.003549
626 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 3 27 0.0004775 0.003549
627 RESPONSE TO INTERLEUKIN 1 5 115 0.0005136 0.003805
628 RESPONSE TO CALCIUM ION 5 115 0.0005136 0.003805
629 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 0.0005325 0.003908
630 GASTRULATION WITH MOUTH FORMING SECOND 3 28 0.0005325 0.003908
631 PLACENTA BLOOD VESSEL DEVELOPMENT 3 28 0.0005325 0.003908
632 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 3 28 0.0005325 0.003908
633 NEGATIVE REGULATION OF DENDRITE DEVELOPMENT 3 28 0.0005325 0.003908
634 MORPHOGENESIS OF A POLARIZED EPITHELIUM 3 28 0.0005325 0.003908
635 RESPONSE TO STEROID HORMONE 10 497 0.0005556 0.004065
636 MAMMARY GLAND DEVELOPMENT 5 117 0.0005557 0.004065
637 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 12 689 0.0005671 0.004143
638 POSITIVE REGULATION OF NEURON DEATH 4 67 0.000582 0.004244
639 EMBRYONIC HINDLIMB MORPHOGENESIS 3 29 0.0005915 0.004307
640 CELLULAR MACROMOLECULE LOCALIZATION 17 1234 0.0006142 0.004465
641 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 4 68 0.0006157 0.004469
642 REGULATION OF SECRETION 12 699 0.0006438 0.004666
643 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 121 0.0006475 0.004681
644 REGULATION OF SYSTEM PROCESS 10 507 0.0006479 0.004681
645 POSITIVE REGULATION OF AXONOGENESIS 4 69 0.0006507 0.004687
646 SYNAPSE ASSEMBLY 4 69 0.0006507 0.004687
647 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE BY P53 CLASS MEDIATOR 3 30 0.0006545 0.004693
648 NEGATIVE REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 3 30 0.0006545 0.004693
649 MYOTUBE CELL DEVELOPMENT 3 30 0.0006545 0.004693
650 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 5 122 0.0006721 0.004811
651 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 4 70 0.0006871 0.004911
652 EPITHELIAL CELL DEVELOPMENT 6 186 0.0006935 0.004949
653 POSITIVE REGULATION OF MITOTIC CELL CYCLE 5 123 0.0006975 0.00497
654 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 4 71 0.000725 0.005134
655 SKIN EPIDERMIS DEVELOPMENT 4 71 0.000725 0.005134
656 SYNAPTIC SIGNALING 9 424 0.0007244 0.005134
657 CELL FATE SPECIFICATION 4 71 0.000725 0.005134
658 ENDOTHELIAL CELL DIFFERENTIATION 4 72 0.0007643 0.005396
659 REGULATION OF HORMONE SECRETION 7 262 0.0007642 0.005396
660 REGULATION OF ORGAN FORMATION 3 32 0.000793 0.005574
661 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 0.000793 0.005574
662 POSITIVE REGULATION OF EPIDERMIS DEVELOPMENT 3 32 0.000793 0.005574
663 NEGATIVE REGULATION OF MAP KINASE ACTIVITY 4 73 0.0008051 0.005625
664 PANCREAS DEVELOPMENT 4 73 0.0008051 0.005625
665 EMBRYONIC HEART TUBE DEVELOPMENT 4 73 0.0008051 0.005625
666 G1 DNA DAMAGE CHECKPOINT 4 73 0.0008051 0.005625
667 REGULATION OF DENDRITE MORPHOGENESIS 4 74 0.0008474 0.005885
668 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 4 74 0.0008474 0.005885
669 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 0.0008474 0.005885
670 CELL CELL JUNCTION ASSEMBLY 4 74 0.0008474 0.005885
671 REGULATION OF REPRODUCTIVE PROCESS 5 129 0.0008648 0.005988
672 CELL JUNCTION ASSEMBLY 5 129 0.0008648 0.005988
673 NEURAL CREST CELL DIFFERENTIATION 4 75 0.0008912 0.006162
674 ORGAN FORMATION 3 34 0.0009489 0.006541
675 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 3 34 0.0009489 0.006541
676 CELL PART MORPHOGENESIS 11 633 0.0009867 0.006791
677 REGULATION OF GASTRULATION 3 35 0.001034 0.007093
678 RESPONSE TO MINERALOCORTICOID 3 35 0.001034 0.007093
679 ACTIN FILAMENT BASED PROCESS 9 450 0.0011 0.00754
680 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 3 36 0.001123 0.007672
681 HEAD MORPHOGENESIS 3 36 0.001123 0.007672
682 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 7 280 0.001125 0.007676
683 HINDBRAIN DEVELOPMENT 5 137 0.001132 0.007714
684 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 4 81 0.001188 0.008084
685 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 207 0.001207 0.008196
686 HINDLIMB MORPHOGENESIS 3 37 0.001217 0.00823
687 MYOBLAST DIFFERENTIATION 3 37 0.001217 0.00823
688 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 0.001217 0.00823
689 JNK CASCADE 4 82 0.001244 0.0084
690 REGULATION OF SYNAPTIC PLASTICITY 5 140 0.001247 0.008408
691 REGULATION OF CALCIUM ION TRANSPORT 6 209 0.001268 0.008523
692 REGULATION OF PEPTIDE SECRETION 6 209 0.001268 0.008523
693 HAIR CYCLE 4 83 0.001301 0.008711
694 EMBRYONIC PLACENTA DEVELOPMENT 4 83 0.001301 0.008711
695 MOLTING CYCLE 4 83 0.001301 0.008711
696 REGULATION OF DEFENSE RESPONSE 12 759 0.00131 0.008759
697 CELLULAR CATABOLIC PROCESS 17 1322 0.001314 0.008769
698 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 3 38 0.001316 0.008771
699 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 4 84 0.00136 0.009042
700 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 4 84 0.00136 0.009042
701 ENDOMEMBRANE SYSTEM ORGANIZATION 9 465 0.001381 0.009166
702 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 6 213 0.001396 0.009255
703 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 144 0.001413 0.009351
704 POSITIVE REGULATION OF VIRAL TRANSCRIPTION 3 39 0.001419 0.009354
705 NEGATIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 3 39 0.001419 0.009354
706 TRABECULA MORPHOGENESIS 3 39 0.001419 0.009354
707 EPHRIN RECEPTOR SIGNALING PATHWAY 4 85 0.001421 0.009354
708 RESPONSE TO IONIZING RADIATION 5 145 0.001457 0.009546
709 SYNAPSE ORGANIZATION 5 145 0.001457 0.009546
710 NEGATIVE REGULATION OF MAPK CASCADE 5 145 0.001457 0.009546
711 HOMEOSTATIC PROCESS 17 1337 0.001483 0.009708
712 RESPONSE TO ESTRADIOL 5 146 0.001502 0.009785
713 T CELL RECEPTOR SIGNALING PATHWAY 5 146 0.001502 0.009785
714 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 6 216 0.001499 0.009785
715 APICAL JUNCTION ASSEMBLY 3 40 0.001528 0.009918
716 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.001528 0.009918
717 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 3 40 0.001528 0.009918
NumGOOverlapSizeP ValueAdj. P Value
1 FRIZZLED BINDING 16 36 2.759e-27 2.563e-24
2 WNT PROTEIN BINDING 15 31 2.332e-26 1.083e-23
3 BETA CATENIN BINDING 19 84 1.165e-25 3.609e-23
4 WNT ACTIVATED RECEPTOR ACTIVITY 13 22 1.577e-24 3.662e-22
5 ENZYME BINDING 44 1737 2.279e-18 4.235e-16
6 TRANSCRIPTION FACTOR BINDING 24 524 2.008e-15 3.11e-13
7 PROTEIN SERINE THREONINE KINASE ACTIVITY 20 445 8.129e-13 1.079e-10
8 G PROTEIN COUPLED RECEPTOR BINDING 16 259 1.637e-12 1.901e-10
9 KINASE BINDING 22 606 3.602e-12 3.718e-10
10 RECEPTOR BINDING 32 1476 2.312e-11 2.148e-09
11 UBIQUITIN LIKE PROTEIN LIGASE BINDING 15 264 2.81e-11 2.373e-09
12 PROTEIN KINASE ACTIVITY 21 640 7.784e-11 6.026e-09
13 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 10 104 4.04e-10 2.887e-08
14 REGULATORY REGION NUCLEIC ACID BINDING 22 818 1.12e-09 7.43e-08
15 SIGNAL TRANSDUCER ACTIVITY 32 1731 1.336e-09 8.277e-08
16 PROTEIN DOMAIN SPECIFIC BINDING 19 624 2.379e-09 1.381e-07
17 ARMADILLO REPEAT DOMAIN BINDING 5 13 6.835e-09 3.735e-07
18 SMAD BINDING 8 72 7.68e-09 3.963e-07
19 KINASE ACTIVITY 21 842 1.063e-08 5.197e-07
20 RECEPTOR AGONIST ACTIVITY 5 16 2.288e-08 1.063e-06
21 CORE PROMOTER PROXIMAL REGION DNA BINDING 14 371 2.613e-08 1.156e-06
22 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 13 315 2.988e-08 1.262e-06
23 MOLECULAR FUNCTION REGULATOR 26 1353 3.167e-08 1.279e-06
24 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 17 629 1.014e-07 3.923e-06
25 PROTEIN DIMERIZATION ACTIVITY 23 1149 1.114e-07 4.141e-06
26 R SMAD BINDING 5 23 1.708e-07 5.958e-06
27 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 21 992 1.732e-07 5.958e-06
28 RHO GTPASE BINDING 7 78 3.072e-07 1.019e-05
29 I SMAD BINDING 4 11 3.204e-07 1.026e-05
30 GAMMA CATENIN BINDING 4 12 4.784e-07 1.482e-05
31 CALMODULIN BINDING 9 179 8.718e-07 2.531e-05
32 ACTIVATING TRANSCRIPTION FACTOR BINDING 6 57 8.602e-07 2.531e-05
33 MAP KINASE ACTIVITY 4 14 9.59e-07 2.68e-05
34 RECEPTOR ACTIVATOR ACTIVITY 5 32 9.81e-07 2.68e-05
35 CHROMATIN BINDING 13 435 1.206e-06 3.2e-05
36 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 15 588 1.262e-06 3.256e-05
37 DOUBLE STRANDED DNA BINDING 17 764 1.525e-06 3.828e-05
38 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 5 36 1.803e-06 4.409e-05
39 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 11 328 2.796e-06 6.66e-05
40 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 21 1199 3.687e-06 8.562e-05
41 PROTEIN PHOSPHATASE TYPE 2A REGULATOR ACTIVITY 4 21 5.56e-06 0.0001241
42 RECEPTOR REGULATOR ACTIVITY 5 45 5.611e-06 0.0001241
43 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 226 5.941e-06 0.0001276
44 SEQUENCE SPECIFIC DNA BINDING 19 1037 6.043e-06 0.0001276
45 RECEPTOR SIGNALING PROTEIN ACTIVITY 8 172 6.449e-06 0.0001331
46 PDZ DOMAIN BINDING 6 90 1.267e-05 0.0002559
47 IDENTICAL PROTEIN BINDING 20 1209 1.505e-05 0.0002975
48 CALMODULIN DEPENDENT PROTEIN KINASE ACTIVITY 4 28 1.844e-05 0.000357
49 ENZYME REGULATOR ACTIVITY 17 959 3.01e-05 0.0005706
50 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 5 64 3.212e-05 0.0005969
51 MACROMOLECULAR COMPLEX BINDING 21 1399 3.799e-05 0.000692
52 RIBONUCLEOTIDE BINDING 25 1860 3.912e-05 0.000699
53 P53 BINDING 5 67 4.014e-05 0.0007036
54 PHOSPHORIC ESTER HYDROLASE ACTIVITY 10 368 4.91e-05 0.0008447
55 TRANSCRIPTION COACTIVATOR ACTIVITY 9 296 5.029e-05 0.0008494
56 PROTEIN HOMODIMERIZATION ACTIVITY 14 722 6.256e-05 0.001038
57 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 7 178 7.263e-05 0.001184
58 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 3 15 7.807e-05 0.00125
59 ADENYL NUCLEOTIDE BINDING 21 1514 0.0001178 0.001855
60 PHOSPHATASE REGULATOR ACTIVITY 5 87 0.0001403 0.002172
61 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 5 92 0.0001826 0.00278
62 ENHANCER BINDING 5 93 0.0001921 0.002878
63 GTPASE BINDING 8 295 0.0002903 0.004281
64 REPRESSING TRANSCRIPTION FACTOR BINDING 4 57 0.0003133 0.004548
65 MITOGEN ACTIVATED PROTEIN KINASE BINDING 3 24 0.0003345 0.004781
66 PROTEIN HETERODIMERIZATION ACTIVITY 10 468 0.0003474 0.00489
67 HORMONE RECEPTOR BINDING 6 168 0.0004054 0.005538
68 DRUG BINDING 5 109 0.0004017 0.005538
69 BHLH TRANSCRIPTION FACTOR BINDING 3 28 0.0005325 0.00717
70 NF KAPPAB BINDING 3 30 0.0006545 0.008687
71 PROTEIN C TERMINUS BINDING 6 186 0.0006935 0.009074
72 PHOSPHOLIPASE C ACTIVITY 3 31 0.0007217 0.009312
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALOSOME 9 11 2.507e-19 1.464e-16
2 BETA CATENIN DESTRUCTION COMPLEX 9 14 8.998e-18 2.627e-15
3 PHOSPHATASE COMPLEX 10 48 1.32e-13 2.57e-11
4 CATALYTIC COMPLEX 28 1038 3.485e-12 5.088e-10
5 PROTEIN PHOSPHATASE TYPE 2A COMPLEX 7 20 1.183e-11 1.382e-09
6 TRANSCRIPTION FACTOR COMPLEX 15 298 1.546e-10 1.504e-08
7 NUCLEAR CHROMATIN 13 291 1.17e-08 9.666e-07
8 LATERAL PLASMA MEMBRANE 7 50 1.324e-08 9.666e-07
9 ENDOCYTIC VESICLE MEMBRANE 10 152 1.653e-08 1.072e-06
10 CHROMOSOME 21 880 2.28e-08 1.332e-06
11 CHROMATIN 15 441 3.174e-08 1.685e-06
12 TRANSCRIPTIONAL REPRESSOR COMPLEX 7 74 2.132e-07 1.037e-05
13 ENDOCYTIC VESICLE 11 256 2.455e-07 1.103e-05
14 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 8 127 6.635e-07 2.768e-05
15 SCF UBIQUITIN LIGASE COMPLEX 5 34 1.343e-06 4.903e-05
16 SYNAPSE 17 754 1.274e-06 4.903e-05
17 EXTRACELLULAR MATRIX 12 426 5.816e-06 0.0001982
18 PROTEINACEOUS EXTRACELLULAR MATRIX 11 356 6.109e-06 0.0001982
19 LAMELLIPODIUM 8 172 6.449e-06 0.0001982
20 NUCLEAR CHROMOSOME 13 523 8.983e-06 0.0002623
21 TRANSFERASE COMPLEX 15 703 1.1e-05 0.0003059
22 PROTEIN KINASE COMPLEX 6 90 1.267e-05 0.0003364
23 CYTOSKELETAL PART 22 1436 1.755e-05 0.0004455
24 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 6 101 2.451e-05 0.0005965
25 INTRACELLULAR VESICLE 19 1259 8.747e-05 0.002043
26 CYTOSKELETON 25 1967 9.739e-05 0.002187
27 MICROTUBULE CYTOSKELETON 17 1068 0.0001137 0.00246
28 VESICLE MEMBRANE 11 512 0.0001664 0.00347
29 NUCLEOPLASM PART 13 708 0.000199 0.004007
30 CELL SURFACE 13 757 0.0003789 0.007376
31 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 7 237 0.0004218 0.007946
32 CHROMOSOME CENTROMERIC REGION 6 174 0.0004883 0.008642
33 CENTROSOME 10 487 0.0004745 0.008642

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 114 151 4.167e-269 7.376e-267
2 hsa04916_Melanogenesis 38 101 3.655e-61 3.235e-59
3 hsa04114_Oocyte_meiosis 21 114 3.012e-26 1.777e-24
4 hsa04720_Long.term_potentiation 17 70 1.254e-23 5.549e-22
5 hsa04520_Adherens_junction 17 73 2.775e-23 9.824e-22
6 hsa04340_Hedgehog_signaling_pathway 15 56 1.123e-21 3.312e-20
7 hsa04662_B_cell_receptor_signaling_pathway 15 75 1.441e-19 3.645e-18
8 hsa04010_MAPK_signaling_pathway 21 268 3.008e-18 6.656e-17
9 hsa04370_VEGF_signaling_pathway 14 76 8.59e-18 1.689e-16
10 hsa04912_GnRH_signaling_pathway 15 101 1.666e-17 2.949e-16
11 hsa04360_Axon_guidance 16 130 2.968e-17 4.775e-16
12 hsa04350_TGF.beta_signaling_pathway 14 85 4.553e-17 6.715e-16
13 hsa04660_T_cell_receptor_signaling_pathway 14 108 1.503e-15 2.023e-14
14 hsa04510_Focal_adhesion 17 200 1.6e-15 2.023e-14
15 hsa04110_Cell_cycle 14 128 1.703e-14 2.01e-13
16 hsa04650_Natural_killer_cell_mediated_cytotoxicity 14 136 4.009e-14 4.435e-13
17 hsa04012_ErbB_signaling_pathway 12 87 8.064e-14 8.396e-13
18 hsa04020_Calcium_signaling_pathway 15 177 8.554e-14 8.411e-13
19 hsa04971_Gastric_acid_secretion 11 74 3.9e-13 3.634e-12
20 hsa04722_Neurotrophin_signaling_pathway 12 127 8.091e-12 7.161e-11
21 hsa04380_Osteoclast_differentiation 12 128 8.886e-12 7.49e-11
22 hsa04062_Chemokine_signaling_pathway 12 189 8.52e-10 6.855e-09
23 hsa04270_Vascular_smooth_muscle_contraction 10 116 1.193e-09 9.179e-09
24 hsa04330_Notch_signaling_pathway 7 47 8.455e-09 6.236e-08
25 hsa04664_Fc_epsilon_RI_signaling_pathway 8 79 1.62e-08 1.147e-07
26 hsa04730_Long.term_depression 7 70 1.447e-07 9.85e-07
27 hsa04710_Circadian_rhythm_._mammal 5 23 1.708e-07 1.119e-06
28 hsa04670_Leukocyte_transendothelial_migration 8 117 3.539e-07 2.237e-06
29 hsa04210_Apoptosis 7 89 7.609e-07 4.489e-06
30 hsa04970_Salivary_secretion 7 89 7.609e-07 4.489e-06
31 hsa04540_Gap_junction 7 90 8.212e-07 4.689e-06
32 hsa04530_Tight_junction 8 133 9.428e-07 5.215e-06
33 hsa04972_Pancreatic_secretion 7 101 1.796e-06 9.631e-06
34 hsa03015_mRNA_surveillance_pathway 6 83 7.934e-06 4.13e-05
35 hsa04620_Toll.like_receptor_signaling_pathway 6 102 2.593e-05 0.0001311
36 hsa04810_Regulation_of_actin_cytoskeleton 8 214 3.14e-05 0.0001544
37 hsa04115_p53_signaling_pathway 5 69 4.629e-05 0.0002214
38 hsa04070_Phosphatidylinositol_signaling_system 5 78 8.349e-05 0.0003889
39 hsa04910_Insulin_signaling_pathway 6 138 0.0001401 0.0006208
40 hsa04914_Progesterone.mediated_oocyte_maturation 5 87 0.0001403 0.0006208
41 hsa04120_Ubiquitin_mediated_proteolysis 6 139 0.0001458 0.0006294
42 hsa04630_Jak.STAT_signaling_pathway 6 155 0.0002634 0.00111
43 hsa04621_NOD.like_receptor_signaling_pathway 4 59 0.0003579 0.001473
44 hsa04141_Protein_processing_in_endoplasmic_reticulum 6 168 0.0004054 0.001631
45 hsa04622_RIG.I.like_receptor_signaling_pathway 4 71 0.000725 0.002852
46 hsa04666_Fc_gamma_R.mediated_phagocytosis 4 95 0.002139 0.008232
47 hsa04742_Taste_transduction 3 52 0.003253 0.01225
48 hsa00562_Inositol_phosphate_metabolism 3 57 0.004219 0.01556
49 hsa04920_Adipocytokine_signaling_pathway 3 68 0.006907 0.02495
50 hsa04740_Olfactory_transduction 6 388 0.02378 0.08297
51 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.02391 0.08297
52 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.02607 0.08708
53 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.02607 0.08708
54 hsa04976_Bile_secretion 2 71 0.06207 0.2034
55 hsa03008_Ribosome_biogenesis_in_eukaryotes 2 81 0.07805 0.2512
56 hsa04144_Endocytosis 3 203 0.1099 0.3474

Quest ID: bb7ee088f5236f1d0acd75285ff60648