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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-942-5p ACADL 1.91 0 -4.56 0 MirTarget -0.64 0.0003 NA
2 hsa-miR-199a-3p ACOX1 0.85 0.00036 -0.89 0.00024 PITA -0.4 0 NA
3 hsa-miR-199b-3p ACOX1 0.86 0.00032 -0.89 0.00024 PITA -0.4 0 NA
4 hsa-miR-23a-3p ACOX1 1.11 0 -0.89 0.00024 mirMAP -0.46 0 NA
5 hsa-miR-409-3p ACOX1 0.65 0.05151 -0.89 0.00024 mirMAP -0.15 0.00302 NA
6 hsa-miR-424-5p ACOX1 1.09 0.00042 -0.89 0.00024 miRNATAP -0.16 0.00524 NA
7 hsa-miR-708-3p ACOX1 0.62 0.27536 -0.89 0.00024 mirMAP -0.2 0 NA
8 hsa-miR-429 ACOX2 1.4 0.009 -1.9 8.0E-5 miRanda; miRNATAP -0.21 0.00122 NA
9 hsa-miR-590-3p ACOX2 1.12 0.00016 -1.9 8.0E-5 miRanda -0.35 0.00303 NA
10 hsa-miR-455-5p ACOX3 1.2 7.0E-5 -1 4.0E-5 miRanda -0.2 0.00044 NA
11 hsa-miR-130b-3p ACSL1 1.33 5.0E-5 -0.82 0.0037 MirTarget; miRNATAP -0.17 0.00551 NA
12 hsa-miR-181b-5p ACSL1 1.64 0 -0.82 0.0037 MirTarget -0.22 0.00084 NA
13 hsa-miR-191-5p ACSL1 0.96 0.00071 -0.82 0.0037 miRNAWalker2 validate -0.36 0 NA
14 hsa-miR-2110 ACSL1 0.76 0.0724 -0.82 0.0037 MirTarget -0.15 0.00173 NA
15 hsa-miR-301a-3p ACSL1 1.45 1.0E-5 -0.82 0.0037 MirTarget; miRNATAP -0.17 0.00736 NA
16 hsa-miR-335-5p ACSL1 1.6 6.0E-5 -0.82 0.0037 miRNAWalker2 validate -0.17 0.00066 NA
17 hsa-miR-454-3p ACSL1 0.63 0.01349 -0.82 0.0037 MirTarget -0.23 0.00374 NA
18 hsa-miR-93-3p ACSL1 1.89 0 -0.82 0.0037 miRNAWalker2 validate -0.19 0.00106 NA
19 hsa-miR-421 ACSL3 1.81 0 -0.82 2.0E-5 miRanda -0.1 0.00915 NA
20 hsa-miR-224-3p ACSL4 1.52 0.0065 0.01 0.96386 MirTarget -0.12 0.00051 NA
21 hsa-miR-3065-3p ACSL4 -1.04 0.02184 0.01 0.96386 MirTarget; miRNATAP -0.1 0.00804 NA
22 hsa-miR-378a-3p ACSL4 -0.19 0.5308 0.01 0.96386 miRNAWalker2 validate -0.21 0.0002 NA
23 hsa-miR-24-3p ACSL6 1.09 0 -1.14 0.09998 MirTarget -0.84 0.00014 NA
24 hsa-miR-455-3p ACSL6 2.3 0 -1.14 0.09998 PITA -0.4 0.0002 NA
25 hsa-miR-455-5p ACSL6 1.2 7.0E-5 -1.14 0.09998 miRanda -0.46 0.00437 NA
26 hsa-miR-21-3p ADIPOQ 1.75 0 -5.93 0 MirTarget -0.77 4.0E-5 NA
27 hsa-miR-320b ADIPOQ 1.11 0.0005 -5.93 0 miRanda -0.58 0.00065 NA
28 hsa-miR-3662 ADIPOQ 1.83 0.0054 -5.93 0 mirMAP; miRNATAP -0.33 0.00215 NA
29 hsa-miR-429 ADIPOQ 1.4 0.009 -5.93 0 miRanda -0.37 0.00026 NA
30 hsa-miR-940 ADIPOQ 1.64 0.00069 -5.93 0 MirTarget -0.38 0.00425 NA
31 hsa-miR-214-3p AQP7 1.01 0.00625 -1.85 0.0207 mirMAP -0.61 7.0E-5 NA
32 hsa-miR-335-5p CD36 1.6 6.0E-5 -2.35 2.0E-5 miRNAWalker2 validate -0.53 0 NA
33 hsa-miR-361-5p CD36 0.41 0.01813 -2.35 2.0E-5 miRanda -0.98 3.0E-5 NA
34 hsa-miR-3662 CD36 1.83 0.0054 -2.35 2.0E-5 mirMAP -0.3 0.0001 NA
35 hsa-miR-421 CD36 1.81 0 -2.35 2.0E-5 miRanda -0.43 9.0E-5 NA
36 hsa-miR-629-3p CD36 1.4 0.0001 -2.35 2.0E-5 MirTarget -0.44 4.0E-5 NA
37 hsa-miR-96-5p CD36 1.14 0.00943 -2.35 2.0E-5 MirTarget -0.28 0.00282 NA
38 hsa-miR-543 CPT1B 0.03 0.92946 -0.52 0.05906 PITA -0.17 0.00428 NA
39 hsa-miR-218-5p FABP1 -0.99 0.01083 2.57 0.08106 mirMAP -2.01 0 NA
40 hsa-miR-342-3p FABP1 0.32 0.26915 2.57 0.08106 miRanda -1.04 0.00458 NA
41 hsa-miR-34c-5p FABP1 2.21 0.00038 2.57 0.08106 miRanda -1.01 0 NA
42 hsa-miR-199a-5p FABP2 0.37 0.23266 2.01 0.07561 miRanda -1.01 9.0E-5 NA
43 hsa-miR-944 FABP2 3.33 0.01778 2.01 0.07561 mirMAP -0.48 0 NA
44 hsa-miR-335-5p FABP4 1.6 6.0E-5 -2.71 0.01064 miRNAWalker2 validate -1.04 0 NA
45 hsa-miR-338-5p FABP4 -1.2 0.01003 -2.71 0.01064 miRNATAP -0.69 2.0E-5 NA
46 hsa-miR-589-3p FABP4 1.02 0.00578 -2.71 0.01064 MirTarget -0.8 7.0E-5 NA
47 hsa-miR-217 FABP5 -0.01 0.98082 1.56 0.04444 miRanda -0.46 3.0E-5 NA
48 hsa-miR-2110 FADS2 0.76 0.0724 0.87 0.08837 miRNATAP -0.26 0.00326 NA
49 hsa-miR-944 GK 3.33 0.01778 1.1 0.00224 MirTarget; PITA -0.12 0 NA
50 hsa-miR-199a-5p HMGCS2 0.37 0.23266 -4.27 0.00932 miRanda -1.91 0 NA
51 hsa-miR-185-3p ILK 1.34 3.0E-5 -0.7 0.00014 MirTarget; miRNATAP -0.12 0.00261 NA
52 hsa-miR-222-3p ILK 1.39 0 -0.7 0.00014 miRNAWalker2 validate -0.19 3.0E-5 NA
53 hsa-miR-335-3p ILK 2.52 0 -0.7 0.00014 MirTarget -0.13 2.0E-5 NA
54 hsa-miR-342-5p ILK 0.69 0.031 -0.7 0.00014 miRNATAP -0.12 0.00265 NA
55 hsa-miR-142-3p ME1 1.32 0.00015 -0.01 0.9842 PITA; miRanda -0.24 0.00327 NA
56 hsa-miR-30a-5p ME1 -1.72 0 -0.01 0.9842 miRNATAP -0.28 0.00074 NA
57 hsa-miR-30c-5p ME1 -0.98 5.0E-5 -0.01 0.9842 miRNATAP -0.37 0.00135 NA
58 hsa-miR-145-5p MMP1 -1.75 2.0E-5 4.95 0 miRNAWalker2 validate -0.56 2.0E-5 NA
59 hsa-miR-326 OLR1 -0.43 0.26299 3.54 0 miRanda -0.36 0.00309 NA
60 hsa-miR-199a-5p PCK1 0.37 0.23266 0.61 0.61617 miRanda -0.88 0.00165 NA
61 hsa-miR-22-5p PDPK1 0.8 0.0008 -0.59 4.0E-5 miRNATAP -0.13 0.00306 NA
62 hsa-miR-24-3p PDPK1 1.09 0 -0.59 4.0E-5 miRNAWalker2 validate -0.14 0.00295 NA
63 hsa-miR-27a-3p PDPK1 1.3 0 -0.59 4.0E-5 miRNATAP -0.13 0.00311 NA
64 hsa-miR-424-5p PDPK1 1.09 0.00042 -0.59 4.0E-5 mirMAP -0.13 0.00011 NA
65 hsa-miR-542-3p PDPK1 0.76 0.00211 -0.59 4.0E-5 mirMAP -0.16 0.00014 NA
66 hsa-let-7i-5p PPARA 0.8 3.0E-5 -0.65 0.00315 miRNATAP -0.4 0 NA
67 hsa-miR-106b-5p PPARA 1.71 0 -0.65 0.00315 miRNATAP -0.14 0.00437 NA
68 hsa-miR-127-5p PPARA 0.68 0.02163 -0.65 0.00315 mirMAP -0.24 1.0E-5 NA
69 hsa-miR-136-3p PPARA -0.64 0.02189 -0.65 0.00315 mirMAP -0.16 0.00585 NA
70 hsa-miR-136-5p PPARA -0.39 0.19926 -0.65 0.00315 mirMAP -0.15 0.0038 NA
71 hsa-miR-146b-3p PPARA 1.1 4.0E-5 -0.65 0.00315 mirMAP -0.19 0.00083 NA
72 hsa-miR-146b-5p PPARA 1.55 0 -0.65 0.00315 mirMAP -0.19 0.0005 NA
73 hsa-miR-181a-2-3p PPARA 0.9 0.00083 -0.65 0.00315 mirMAP -0.2 0.00051 NA
74 hsa-miR-181b-5p PPARA 1.64 0 -0.65 0.00315 miRNATAP -0.14 0.00575 NA
75 hsa-miR-18a-5p PPARA 2.2 0 -0.65 0.00315 mirMAP -0.11 0.00985 NA
76 hsa-miR-193b-5p PPARA 0.61 0.13924 -0.65 0.00315 mirMAP -0.17 1.0E-5 NA
77 hsa-miR-21-5p PPARA 1.75 0 -0.65 0.00315 miRNAWalker2 validate; miRTarBase; miRNATAP -0.25 0.00183 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways
78 hsa-miR-218-5p PPARA -0.99 0.01083 -0.65 0.00315 mirMAP -0.11 0.00611 NA
79 hsa-miR-24-3p PPARA 1.09 0 -0.65 0.00315 MirTarget -0.38 0 NA
80 hsa-miR-27a-3p PPARA 1.3 0 -0.65 0.00315 MirTarget; miRNATAP -0.29 1.0E-5 NA
81 hsa-miR-369-3p PPARA 0.32 0.35899 -0.65 0.00315 mirMAP -0.2 1.0E-5 NA
82 hsa-miR-382-5p PPARA 0.59 0.04514 -0.65 0.00315 mirMAP -0.23 1.0E-5 NA
83 hsa-miR-409-3p PPARA 0.65 0.05151 -0.65 0.00315 mirMAP -0.13 0.00519 NA
84 hsa-miR-409-5p PPARA 1.11 0.00089 -0.65 0.00315 MirTarget -0.22 0 NA
85 hsa-miR-421 PPARA 1.81 0 -0.65 0.00315 miRanda; mirMAP -0.12 0.00869 NA
86 hsa-miR-455-5p PPARA 1.2 7.0E-5 -0.65 0.00315 miRanda -0.16 0.0018 NA
87 hsa-miR-543 PPARA 0.03 0.92946 -0.65 0.00315 miRanda -0.18 0.00016 NA
88 hsa-miR-654-3p PPARA -0.18 0.60394 -0.65 0.00315 mirMAP -0.15 0.00086 NA
89 hsa-miR-940 PPARA 1.64 0.00069 -0.65 0.00315 mirMAP -0.17 0 NA
90 hsa-miR-129-5p PPARD -2.57 0 -0.04 0.8611 miRanda -0.11 0.00037 NA
91 hsa-miR-148a-3p PPARD -1.54 4.0E-5 -0.04 0.8611 mirMAP -0.15 0.00111 NA
92 hsa-miR-30b-3p PPARD -0.27 0.40085 -0.04 0.8611 mirMAP -0.15 0.00807 NA
93 hsa-miR-326 PPARD -0.43 0.26299 -0.04 0.8611 miRanda; mirMAP -0.12 0.00819 NA
94 hsa-miR-423-5p PPARD 0.83 0.00079 -0.04 0.8611 MirTarget; mirMAP -0.28 7.0E-5 NA
95 hsa-miR-454-3p PPARD 0.63 0.01349 -0.04 0.8611 mirMAP -0.19 0.00667 NA
96 hsa-miR-497-5p PPARD -0.8 0.0036 -0.04 0.8611 mirMAP -0.17 0.00665 NA
97 hsa-miR-625-3p PPARD -0.19 0.62622 -0.04 0.8611 mirMAP -0.14 0.00179 NA
98 hsa-miR-127-3p PPARG 0.21 0.46101 -0.72 0.33883 miRanda -0.72 0.00011 NA
99 hsa-miR-130a-3p PPARG 0.15 0.63374 -0.72 0.33883 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -1.01 0 NA
100 hsa-miR-199a-5p PPARG 0.37 0.23266 -0.72 0.33883 miRanda -0.69 5.0E-5 NA
101 hsa-miR-27a-3p PPARG 1.3 0 -0.72 0.33883 MirTarget; miRNATAP -1.49 0 NA
102 hsa-miR-27b-3p PPARG 0.08 0.72527 -0.72 0.33883 miRNAWalker2 validate; MirTarget; miRNATAP -1.09 0 NA
103 hsa-miR-34c-5p PPARG 2.21 0.00038 -0.72 0.33883 miRanda -0.5 0 NA
104 hsa-miR-455-5p PPARG 1.2 7.0E-5 -0.72 0.33883 miRanda -0.79 0 NA
105 hsa-let-7g-3p RXRG 0.65 0.01031 -3.75 0 MirTarget; miRNATAP -0.99 0 NA
106 hsa-miR-10a-5p SCD -0.47 0.1488 1.71 3.0E-5 miRNAWalker2 validate -0.34 0.00021 NA
107 hsa-miR-192-5p SCD 0.08 0.94106 1.71 3.0E-5 miRNAWalker2 validate -0.12 0 NA
108 hsa-miR-30a-5p SCD -1.72 0 1.71 3.0E-5 miRNAWalker2 validate -0.41 0 NA
109 hsa-miR-664a-5p SCD -0.13 0.62435 1.71 3.0E-5 MirTarget -0.4 0.00023 NA
110 hsa-miR-126-5p SCD5 0.42 0.07532 -1.16 0.00344 mirMAP -0.44 0.0003 NA
111 hsa-miR-140-3p SCD5 -0.3 0.12754 -1.16 0.00344 miRNAWalker2 validate -0.41 0.0061 NA
112 hsa-miR-150-5p SCD5 0.15 0.75372 -1.16 0.00344 MirTarget -0.24 9.0E-5 NA
113 hsa-miR-17-5p SCD5 1.66 0 -1.16 0.00344 TargetScan -0.24 0.00677 NA
114 hsa-miR-320a SCD5 0.59 0.0119 -1.16 0.00344 miRanda -0.34 0.00522 NA
115 hsa-miR-330-3p SCD5 0.8 0.00747 -1.16 0.00344 PITA -0.33 0.00053 NA
116 hsa-miR-339-5p SCD5 0.77 0.00817 -1.16 0.00344 miRanda -0.25 0.00965 NA
117 hsa-miR-362-3p SCD5 -0.03 0.91378 -1.16 0.00344 miRanda -0.36 6.0E-5 NA
118 hsa-miR-421 SCD5 1.81 0 -1.16 0.00344 miRanda -0.22 0.00702 NA
119 hsa-miR-590-5p SCD5 1.04 0.00027 -1.16 0.00344 miRanda -0.26 0.00994 NA
120 hsa-miR-592 SCD5 0.78 0.2045 -1.16 0.00344 MirTarget -0.22 1.0E-5 NA
121 hsa-miR-92a-3p SCD5 1.22 1.0E-5 -1.16 0.00344 miRNAWalker2 validate -0.27 0.00986 NA
122 hsa-miR-127-5p SCP2 0.68 0.02163 -0.54 0.0021 PITA; miRNATAP -0.2 0 NA
123 hsa-miR-146b-5p SCP2 1.55 0 -0.54 0.0021 miRanda -0.13 0.00335 NA
124 hsa-miR-193b-3p SCP2 0.28 0.45126 -0.54 0.0021 MirTarget -0.17 0 NA
125 hsa-miR-28-5p SCP2 -0.24 0.16732 -0.54 0.0021 miRanda -0.2 0.00868 NA
126 hsa-miR-452-5p SCP2 2.09 0.00026 -0.54 0.0021 MirTarget -0.12 0 NA
127 hsa-miR-769-5p SCP2 1.15 0 -0.54 0.0021 miRNAWalker2 validate -0.15 0.0039 NA
128 hsa-miR-18a-5p SLC27A1 2.2 0 -0.62 0.01517 mirMAP -0.16 0.00056 NA
129 hsa-miR-324-5p SLC27A1 1.09 3.0E-5 -0.62 0.01517 miRanda -0.22 0.0015 NA
130 hsa-miR-421 SLC27A1 1.81 0 -0.62 0.01517 miRanda; mirMAP -0.21 4.0E-5 NA
131 hsa-miR-940 SLC27A1 1.64 0.00069 -0.62 0.01517 MirTarget -0.18 4.0E-5 NA
132 hsa-let-7b-5p SLC27A2 0.06 0.7814 2.11 0.00358 miRNAWalker2 validate -1.14 0 NA
133 hsa-miR-125a-5p SLC27A4 -0.88 0.00021 0.39 0.15278 mirMAP; miRNATAP -0.44 0 NA
134 hsa-miR-125b-5p SLC27A4 -0.51 0.13327 0.39 0.15278 mirMAP; miRNATAP -0.25 1.0E-5 NA
135 hsa-miR-335-5p SLC27A6 1.6 6.0E-5 -1.91 0.0441 miRNAWalker2 validate -0.48 0.00446 NA
136 hsa-miR-577 SLC27A6 0.91 0.22561 -1.91 0.0441 MirTarget -0.55 0 NA
137 hsa-miR-590-3p SLC27A6 1.12 0.00016 -1.91 0.0441 miRanda; mirMAP -0.81 0.00034 NA
138 hsa-let-7a-3p SORBS1 0.5 0.04111 -3.44 0 miRNATAP -0.77 0 NA
139 hsa-let-7b-3p SORBS1 0.22 0.29604 -3.44 0 miRNATAP -0.85 1.0E-5 NA
140 hsa-let-7g-3p SORBS1 0.65 0.01031 -3.44 0 miRNATAP -1.02 0 NA
141 hsa-miR-142-5p SORBS1 1.56 1.0E-5 -3.44 0 PITA; miRNATAP -0.51 1.0E-5 NA
142 hsa-miR-146b-5p SORBS1 1.55 0 -3.44 0 miRanda -0.55 5.0E-5 NA
143 hsa-miR-186-5p SORBS1 0.15 0.43471 -3.44 0 mirMAP -0.76 0.0004 NA
144 hsa-miR-19b-1-5p SORBS1 1.39 0 -3.44 0 mirMAP -0.89 0 NA
145 hsa-miR-205-5p SORBS1 3.14 0.02932 -3.44 0 miRNATAP -0.12 3.0E-5 NA
146 hsa-miR-22-5p SORBS1 0.8 0.0008 -3.44 0 mirMAP -0.73 1.0E-5 NA
147 hsa-miR-3065-5p SORBS1 -0.24 0.63312 -3.44 0 mirMAP -0.32 0.0001 NA
148 hsa-miR-320a SORBS1 0.59 0.0119 -3.44 0 miRNAWalker2 validate; mirMAP -0.54 0.00184 NA
149 hsa-miR-320b SORBS1 1.11 0.0005 -3.44 0 mirMAP -0.66 0 NA
150 hsa-miR-320c SORBS1 0.46 0.24061 -3.44 0 mirMAP -0.39 0.00138 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELLULAR LIPID METABOLIC PROCESS 28 913 5.965e-30 2.776e-26
2 FATTY ACID METABOLIC PROCESS 21 296 4.227e-29 9.834e-26
3 LIPID METABOLIC PROCESS 29 1158 9.237e-29 1.433e-25
4 MONOCARBOXYLIC ACID METABOLIC PROCESS 22 503 6.306e-26 7.335e-23
5 FATTY ACID TRANSPORT 13 56 7.428e-25 6.913e-22
6 ORGANIC ACID METABOLIC PROCESS 23 953 2.382e-21 1.848e-18
7 CELLULAR LIPID CATABOLIC PROCESS 14 151 8.746e-21 5.814e-18
8 MONOCARBOXYLIC ACID TRANSPORT 13 124 4.982e-20 2.897e-17
9 LONG CHAIN FATTY ACID METABOLIC PROCESS 12 88 5.954e-20 3.078e-17
10 LONG CHAIN FATTY ACID TRANSPORT 10 42 2.372e-19 1.104e-16
11 SMALL MOLECULE METABOLIC PROCESS 26 1767 3.192e-19 1.35e-16
12 LIPID CATABOLIC PROCESS 14 247 9.856e-18 3.822e-15
13 LIPID LOCALIZATION 14 264 2.516e-17 9.005e-15
14 LIPID OXIDATION 10 70 6.17e-17 2.051e-14
15 FATTY ACID CATABOLIC PROCESS 10 73 9.627e-17 2.986e-14
16 FATTY ACID BETA OXIDATION 9 51 3.333e-16 9.693e-14
17 ORGANIC ACID TRANSPORT 13 261 9.561e-16 2.617e-13
18 MONOCARBOXYLIC ACID CATABOLIC PROCESS 10 96 1.697e-15 4.387e-13
19 ORGANIC ANION TRANSPORT 14 387 5.182e-15 1.269e-12
20 LIPID BIOSYNTHETIC PROCESS 15 539 2.072e-14 4.82e-12
21 ANION TRANSPORT 14 507 2.098e-13 4.649e-11
22 NEUTRAL LIPID METABOLIC PROCESS 8 85 3.349e-12 7.083e-10
23 CARBOXYLIC ACID CATABOLIC PROCESS 10 205 3.782e-12 7.332e-10
24 ORGANIC ACID CATABOLIC PROCESS 10 205 3.782e-12 7.332e-10
25 LIPID MODIFICATION 10 210 4.808e-12 8.948e-10
26 SINGLE ORGANISM CATABOLIC PROCESS 16 957 5.502e-12 9.847e-10
27 SMALL MOLECULE CATABOLIC PROCESS 11 328 1.584e-11 2.729e-09
28 OXIDATION REDUCTION PROCESS 15 898 3.18e-11 5.285e-09
29 CELLULAR CATABOLIC PROCESS 17 1322 6.04e-11 9.69e-09
30 SINGLE ORGANISM BIOSYNTHETIC PROCESS 17 1340 7.468e-11 1.158e-08
31 REGULATION OF LIPID METABOLIC PROCESS 10 282 8.84e-11 1.327e-08
32 ION TRANSPORT 16 1262 3.405e-10 4.95e-08
33 SMALL MOLECULE BIOSYNTHETIC PROCESS 11 443 3.908e-10 5.511e-08
34 FATTY ACYL COA METABOLIC PROCESS 6 51 5.262e-10 7.201e-08
35 CATABOLIC PROCESS 18 1773 6.267e-10 8.332e-08
36 ACYL COA BIOSYNTHETIC PROCESS 6 54 7.515e-10 9.451e-08
37 THIOESTER BIOSYNTHETIC PROCESS 6 54 7.515e-10 9.451e-08
38 RESPONSE TO NUTRIENT 8 191 2.286e-09 2.799e-07
39 COENZYME BIOSYNTHETIC PROCESS 7 127 3.776e-09 4.505e-07
40 RESPONSE TO INSULIN 8 205 3.992e-09 4.53e-07
41 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 7 128 3.989e-09 4.53e-07
42 RESPONSE TO EXTRACELLULAR STIMULUS 10 441 6.679e-09 7.4e-07
43 FATTY ACID BETA OXIDATION USING ACYL COA OXIDASE 4 13 7.823e-09 8.272e-07
44 ALPHA LINOLENIC ACID METABOLIC PROCESS 4 13 7.823e-09 8.272e-07
45 THIOESTER METABOLIC PROCESS 6 83 1.055e-08 1.068e-06
46 ACYL COA METABOLIC PROCESS 6 83 1.055e-08 1.068e-06
47 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.22e-08 1.208e-06
48 REGULATION OF FATTY ACID METABOLIC PROCESS 6 87 1.404e-08 1.361e-06
49 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 10 482 1.555e-08 1.476e-06
50 GLYCEROLIPID METABOLIC PROCESS 9 356 1.677e-08 1.561e-06
51 HORMONE MEDIATED SIGNALING PATHWAY 7 158 1.727e-08 1.575e-06
52 COFACTOR BIOSYNTHETIC PROCESS 7 166 2.429e-08 2.174e-06
53 MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS 7 172 3.103e-08 2.725e-06
54 FATTY ACID BETA OXIDATION USING ACYL COA DEHYDROGENASE 4 18 3.325e-08 2.865e-06
55 ORGANIC HYDROXY COMPOUND BIOSYNTHETIC PROCESS 7 175 3.496e-08 2.958e-06
56 RESPONSE TO HORMONE 12 893 5.394e-08 4.46e-06
57 UNSATURATED FATTY ACID METABOLIC PROCESS 6 109 5.463e-08 4.46e-06
58 CELLULAR RESPONSE TO HORMONE STIMULUS 10 552 5.576e-08 4.473e-06
59 LIPID HOMEOSTASIS 6 110 5.771e-08 4.551e-06
60 TRIGLYCERIDE CATABOLIC PROCESS 4 21 6.477e-08 5.023e-06
61 NEUTRAL LIPID CATABOLIC PROCESS 4 26 1.607e-07 1.206e-05
62 ACYLGLYCEROL CATABOLIC PROCESS 4 26 1.607e-07 1.206e-05
63 RESPONSE TO ENDOGENOUS STIMULUS 14 1450 1.922e-07 1.42e-05
64 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 12 1008 2.017e-07 1.466e-05
65 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 4 28 2.195e-07 1.547e-05
66 REGULATION OF FATTY ACID OXIDATION 4 28 2.195e-07 1.547e-05
67 VERY LONG CHAIN FATTY ACID METABOLIC PROCESS 4 29 2.543e-07 1.766e-05
68 CHEMICAL HOMEOSTASIS 11 874 4.242e-07 2.902e-05
69 POSITIVE REGULATION OF FATTY ACID METABOLIC PROCESS 4 33 4.357e-07 2.938e-05
70 RESPONSE TO FATTY ACID 5 83 4.911e-07 3.265e-05
71 COENZYME METABOLIC PROCESS 7 265 5.885e-07 3.857e-05
72 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 36 6.246e-07 4.037e-05
73 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 7 270 6.672e-07 4.196e-05
74 ORGANIC ACID BIOSYNTHETIC PROCESS 7 270 6.672e-07 4.196e-05
75 GLYCEROLIPID CATABOLIC PROCESS 4 37 6.994e-07 4.339e-05
76 RESPONSE TO PEPTIDE 8 404 7.441e-07 4.556e-05
77 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 6 173 8.427e-07 5.093e-05
78 REGULATION OF LIPID TRANSPORT 5 95 9.64e-07 5.751e-05
79 NEGATIVE REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 3 13 1.786e-06 0.0001039
80 REGULATION OF CHOLESTEROL STORAGE 3 13 1.786e-06 0.0001039
81 RESPONSE TO ABIOTIC STIMULUS 11 1024 2.017e-06 0.0001159
82 ALCOHOL BIOSYNTHETIC PROCESS 5 111 2.086e-06 0.0001184
83 SULFUR COMPOUND BIOSYNTHETIC PROCESS 6 203 2.139e-06 0.0001199
84 POSITIVE REGULATION OF FATTY ACID OXIDATION 3 14 2.27e-06 0.0001258
85 COFACTOR METABOLIC PROCESS 7 334 2.751e-06 0.0001506
86 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 3 16 3.484e-06 0.0001885
87 ALCOHOL METABOLIC PROCESS 7 348 3.607e-06 0.0001929
88 HOMEOSTATIC PROCESS 12 1337 4.019e-06 0.0002125
89 BILE ACID BIOSYNTHETIC PROCESS 3 20 7.055e-06 0.0003688
90 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 8.001e-06 0.0004136
91 REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 3 21 8.22e-06 0.0004203
92 REGULATION OF DEFENSE RESPONSE 9 759 9.433e-06 0.0004771
93 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 5 168 1.58e-05 0.0007906
94 RESPONSE TO OXYGEN LEVELS 6 311 2.446e-05 0.001211
95 CARBOHYDRATE TRANSPORT 4 95 3.115e-05 0.001526
96 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 4 100 3.811e-05 0.001828
97 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 3.811e-05 0.001828
98 BILE ACID METABOLIC PROCESS 3 35 3.971e-05 0.001886
99 RESPONSE TO ORGANIC CYCLIC COMPOUND 9 917 4.221e-05 0.001984
100 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY 3 37 4.702e-05 0.002166
101 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 37 4.702e-05 0.002166
102 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 6 351 4.81e-05 0.002194
103 REGULATION OF STEROL TRANSPORT 3 38 5.099e-05 0.002281
104 REGULATION OF CHOLESTEROL TRANSPORT 3 38 5.099e-05 0.002281
105 SULFUR COMPOUND METABOLIC PROCESS 6 359 5.452e-05 0.002416
106 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 5 218 5.503e-05 0.002416
107 STEROID BIOSYNTHETIC PROCESS 4 114 6.364e-05 0.002739
108 REGULATION OF LIPID STORAGE 3 41 6.417e-05 0.002739
109 FATTY ACID BIOSYNTHETIC PROCESS 4 114 6.364e-05 0.002739
110 RESPONSE TO COLD 3 43 7.41e-05 0.003134
111 GLUCOSE METABOLIC PROCESS 4 119 7.522e-05 0.003153
112 STEROID METABOLIC PROCESS 5 237 8.172e-05 0.003395
113 REGULATION OF PLASMA LIPOPROTEIN PARTICLE LEVELS 3 45 8.498e-05 0.003499
114 RESPONSE TO EXTERNAL STIMULUS 12 1821 8.945e-05 0.003651
115 STEROID HORMONE MEDIATED SIGNALING PATHWAY 4 125 9.105e-05 0.003684
116 REGULATION OF LIPID BIOSYNTHETIC PROCESS 4 128 9.982e-05 0.004004
117 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 12 1848 0.0001031 0.004068
118 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 48 0.0001032 0.004068
119 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 8 799 0.0001055 0.004126
120 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 3 49 0.0001098 0.004256
121 REGULATION OF RESPONSE TO WOUNDING 6 413 0.0001179 0.004536
122 MONOSACCHARIDE TRANSPORT 3 54 0.0001468 0.005553
123 REGULATION OF PHOSPHORUS METABOLIC PROCESS 11 1618 0.0001457 0.005553
124 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 0.0001531 0.005746
125 NEGATIVE REGULATION OF DEFENSE RESPONSE 4 144 0.0001573 0.005855
126 CELLULAR RESPONSE TO PEPTIDE 5 274 0.0001613 0.005958
127 RESPONSE TO NITROGEN COMPOUND 8 859 0.000174 0.006353
128 RESPONSE TO TEMPERATURE STIMULUS 4 148 0.0001748 0.006353
129 UNSATURATED FATTY ACID BIOSYNTHETIC PROCESS 3 58 0.0001817 0.006553
130 POSITIVE REGULATION OF MEMBRANE INVAGINATION 2 11 0.0001913 0.006691
131 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 6 450 0.0001881 0.006691
132 LOW DENSITY LIPOPROTEIN PARTICLE CLEARANCE 2 11 0.0001913 0.006691
133 POSITIVE REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 11 0.0001913 0.006691
134 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 4 153 0.0001985 0.006893
135 CELLULAR RESPONSE TO LIPID 6 457 0.0002045 0.007048
136 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 289 0.0002067 0.007071
137 ORGANIC HYDROXY COMPOUND TRANSPORT 4 155 0.0002086 0.007086
138 RESPONSE TO LIPID 8 888 0.0002183 0.00718
139 CARBOHYDRATE METABOLIC PROCESS 7 662 0.0002176 0.00718
140 GENERATION OF PRECURSOR METABOLITES AND ENERGY 5 292 0.0002168 0.00718
141 HEXOSE METABOLIC PROCESS 4 157 0.0002191 0.00718
142 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 4 156 0.0002138 0.00718
143 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 0.0002246 0.007256
144 REGULATION OF INFLAMMATORY RESPONSE 5 294 0.0002238 0.007256
145 REGULATION OF SEQUESTERING OF TRIGLYCERIDE 2 12 0.0002292 0.007306
146 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 12 0.0002292 0.007306
147 WHITE FAT CELL DIFFERENTIATION 2 13 0.0002706 0.008176
148 CELL SUBSTRATE ADHESION 4 164 0.0002589 0.008176
149 LIPOPROTEIN TRANSPORT 2 13 0.0002706 0.008176
150 REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 13 0.0002706 0.008176
151 LIPOPROTEIN LOCALIZATION 2 13 0.0002706 0.008176
152 REGULATION OF PHOSPHOLIPID BIOSYNTHETIC PROCESS 2 13 0.0002706 0.008176
153 NEGATIVE REGULATION OF CARDIAC MUSCLE CELL APOPTOTIC PROCESS 2 13 0.0002706 0.008176
154 REGULATION OF MEMBRANE INVAGINATION 2 13 0.0002706 0.008176
155 POSITIVE REGULATION OF KINASE ACTIVITY 6 482 0.0002724 0.008177
156 RESPONSE TO CARBOHYDRATE 4 168 0.0002838 0.008464
157 REGULATION OF PHAGOCYTOSIS 3 68 0.0002912 0.008631
158 GLUCOSE HOMEOSTASIS 4 170 0.0002968 0.008687
159 CARBOHYDRATE HOMEOSTASIS 4 170 0.0002968 0.008687
160 RESPONSE TO ACTIVITY 3 69 0.0003041 0.008842
161 RESPONSE TO LOW DENSITY LIPOPROTEIN PARTICLE 2 14 0.0003153 0.009001
162 LINOLEIC ACID METABOLIC PROCESS 2 14 0.0003153 0.009001
163 POSITIVE REGULATION OF TRANSPORT 8 936 0.000312 0.009001
164 RESPONSE TO STEROID HORMONE 6 497 0.000321 0.009106
165 RESPONSE TO ACID CHEMICAL 5 319 0.000326 0.009194
166 REGULATION OF TRANSFERASE ACTIVITY 8 946 0.0003352 0.009396
NumGOOverlapSizeP ValueAdj. P Value
1 LONG CHAIN FATTY ACID COA LIGASE ACTIVITY 8 13 9.861e-20 9.161e-17
2 FATTY ACID LIGASE ACTIVITY 8 16 9.821e-19 4.562e-16
3 FATTY ACID BINDING 8 31 5.901e-16 1.827e-13
4 LIGASE ACTIVITY FORMING CARBON SULFUR BONDS 8 40 5.684e-15 1.32e-12
5 MONOCARBOXYLIC ACID BINDING 8 65 3.608e-13 6.703e-11
6 ORGANIC ACID BINDING 10 209 4.585e-12 7.098e-10
7 FATTY ACID TRANSPORTER ACTIVITY 5 12 1.477e-11 1.96e-09
8 FATTY ACYL COA BINDING 5 31 3.087e-09 3.585e-07
9 ACYL COA DEHYDROGENASE ACTIVITY 4 17 2.59e-08 2.673e-06
10 LIPID TRANSPORTER ACTIVITY 6 108 5.17e-08 4.803e-06
11 LIPID BINDING 10 657 2.812e-07 2.375e-05
12 LIGASE ACTIVITY 8 406 7.723e-07 5.979e-05
13 COENZYME BINDING 6 179 1.029e-06 7.35e-05
14 LONG CHAIN FATTY ACID BINDING 3 14 2.27e-06 0.0001318
15 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 4 48 2.03e-06 0.0001318
16 ELECTRON CARRIER ACTIVITY 5 112 2.18e-06 0.0001318
17 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH CH GROUP OF DONORS 4 57 4.071e-06 0.0002224
18 STEROID HORMONE RECEPTOR ACTIVITY 4 59 4.677e-06 0.0002414
19 COFACTOR BINDING 6 263 9.472e-06 0.0004631
20 FLAVIN ADENINE DINUCLEOTIDE BINDING 4 74 1.159e-05 0.0005382
21 OXIDOREDUCTASE ACTIVITY 8 719 5.04e-05 0.00223
22 DRUG BINDING 4 109 5.342e-05 0.002256
23 SULFUR COMPOUND BINDING 5 234 7.695e-05 0.003108
24 TRANSPORTER ACTIVITY 10 1276 9.827e-05 0.003804
NumGOOverlapSizeP ValueAdj. P Value
1 MICROBODY PART 10 93 1.22e-15 7.126e-13
2 MICROBODY 10 134 5.226e-14 1.526e-11
3 MICROBODY MEMBRANE 6 58 1.171e-09 2.28e-07
4 MICROBODY LUMEN 5 45 2.178e-08 3.179e-06
5 MITOCHONDRION 15 1633 1.141e-07 1.333e-05
6 OUTER MEMBRANE 6 190 1.456e-06 0.0001417
7 MITOCHONDRIAL ENVELOPE 9 691 4.417e-06 0.0003685
8 MITOCHONDRIAL PART 9 953 5.695e-05 0.004158
9 NUCLEAR OUTER MEMBRANE ENDOPLASMIC RETICULUM MEMBRANE NETWORK 9 1005 8.583e-05 0.00557
10 ENVELOPE 9 1090 0.0001594 0.008462
11 ENDOPLASMIC RETICULUM 11 1631 0.0001564 0.008462

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03320_PPAR_signaling_pathway 38 70 1.715e-99 3.088e-97
2 hsa04920_Adipocytokine_signaling_pathway 10 68 4.534e-17 4.08e-15
3 hsa00071_Fatty_acid_metabolism 8 43 1.067e-14 6.404e-13
4 hsa04146_Peroxisome 9 79 2.174e-14 9.782e-13
5 hsa01040_Biosynthesis_of_unsaturated_fatty_acids 5 21 3.749e-10 1.35e-08
6 hsa04975_Fat_digestion_and_absorption 4 46 1.707e-06 5.121e-05
7 hsa00592_alpha.Linolenic_acid_metabolism 3 20 7.055e-06 0.0001814
8 hsa00120_Primary_bile_acid_biosynthesis 2 16 0.0004148 0.009333
9 hsa04910_Insulin_signaling_pathway 3 138 0.002272 0.04545
10 hsa00620_Pyruvate_metabolism 2 40 0.00262 0.04716
11 hsa04145_Phagosome 2 156 0.03538 0.4899
12 hsa04510_Focal_adhesion 2 200 0.0553 0.5876
13 hsa04151_PI3K_AKT_signaling_pathway 2 351 0.1432 1

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

PCA3

 hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7g-3p;hsa-miR-186-5p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-22-5p;hsa-miR-320b;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-944 11 SORBS1 Sponge network -2.778 8.0E-5 -3.437 0 0.628
2 CASC2 hsa-miR-127-5p;hsa-miR-136-3p;hsa-miR-136-5p;hsa-miR-193b-5p;hsa-miR-218-5p;hsa-miR-24-3p;hsa-miR-27a-3p;hsa-miR-369-3p;hsa-miR-382-5p;hsa-miR-654-3p;hsa-miR-940 11 PPARA Sponge network -0.561 0.05962 -0.648 0.00315 0.262

Quest ID: bc9b731af385c16d5472ad9f36d46871