Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p AKT3 -0.2 0.80221 0.46 0.53933 miRNATAP -0.55 0 NA
2 hsa-miR-106b-5p AKT3 -0.3 0.86929 0.46 0.53933 miRNATAP -0.91 0 NA
3 hsa-miR-107 AKT3 -0.04 0.98836 0.46 0.53933 PITA; miRanda -0.55 0.00017 NA
4 hsa-miR-1275 AKT3 -0.83 0.08038 0.46 0.53933 PITA -0.27 0 NA
5 hsa-miR-142-3p AKT3 -0.15 0.9461 0.46 0.53933 miRanda -0.2 0.00627 NA
6 hsa-miR-15a-5p AKT3 -0.07 0.96484 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.72 0 NA
7 hsa-miR-15b-5p AKT3 -0.27 0.87097 0.46 0.53933 miRNATAP -0.67 0 NA
8 hsa-miR-16-5p AKT3 0.01 0.99448 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.75 0 NA
9 hsa-miR-17-3p AKT3 0.1 0.96011 0.46 0.53933 miRNATAP -0.52 0 NA
10 hsa-miR-17-5p AKT3 -0.18 0.93454 0.46 0.53933 TargetScan; miRNATAP -0.63 0 NA
11 hsa-miR-181b-5p AKT3 0.16 0.93018 0.46 0.53933 miRNATAP -0.27 0.00963 NA
12 hsa-miR-20a-5p AKT3 -0.18 0.92812 0.46 0.53933 miRNATAP -0.53 0 NA
13 hsa-miR-28-3p AKT3 -0.23 0.93535 0.46 0.53933 miRNATAP -0.52 0.00719 NA
14 hsa-miR-29a-3p AKT3 0.01 0.99698 0.46 0.53933 miRNATAP -0.81 0 NA
15 hsa-miR-29b-3p AKT3 -0.1 0.95899 0.46 0.53933 miRNATAP -0.68 0 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
16 hsa-miR-32-3p AKT3 -0.57 0.13133 0.46 0.53933 mirMAP -0.56 0 NA
17 hsa-miR-320a AKT3 -0.42 0.8402 0.46 0.53933 PITA; miRanda; miRNATAP -0.33 0.00138 NA
18 hsa-miR-320b AKT3 -0.24 0.85922 0.46 0.53933 PITA; miRanda; miRNATAP -0.25 0.00855 NA
19 hsa-miR-335-3p AKT3 -0.24 0.8845 0.46 0.53933 mirMAP -0.58 0 NA
20 hsa-miR-33a-3p AKT3 -0.79 0.01052 0.46 0.53933 mirMAP -0.49 0 NA
21 hsa-miR-340-5p AKT3 -0 0.99757 0.46 0.53933 mirMAP -0.28 0.006 NA
22 hsa-miR-362-3p AKT3 -0.72 0.03459 0.46 0.53933 miRanda -0.42 0 NA
23 hsa-miR-362-5p AKT3 -0.27 0.75202 0.46 0.53933 PITA; TargetScan; miRNATAP -0.52 0 NA
24 hsa-miR-369-3p AKT3 0.12 0.8323 0.46 0.53933 mirMAP -0.23 0.00901 NA
25 hsa-miR-374a-5p AKT3 -0.34 0.76692 0.46 0.53933 mirMAP -0.58 0 NA
26 hsa-miR-374b-5p AKT3 -0.29 0.8357 0.46 0.53933 mirMAP -0.68 0 NA
27 hsa-miR-421 AKT3 -0.18 0.7347 0.46 0.53933 miRanda; mirMAP -0.46 0 NA
28 hsa-miR-424-5p AKT3 0.25 0.87015 0.46 0.53933 miRNATAP -0.24 0.00104 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth
29 hsa-miR-501-3p AKT3 -0.75 0.55276 0.46 0.53933 miRNATAP -0.5 0 NA
30 hsa-miR-502-3p AKT3 -0.48 0.5143 0.46 0.53933 miRNATAP -0.64 0 NA
31 hsa-miR-502-5p AKT3 -0.71 0.02613 0.46 0.53933 PITA; miRNATAP -0.41 0 NA
32 hsa-miR-505-3p AKT3 -0.47 0.69038 0.46 0.53933 mirMAP -0.77 0 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
33 hsa-miR-548o-3p AKT3 -0.19 0.51773 0.46 0.53933 mirMAP -0.31 8.0E-5 NA
34 hsa-miR-577 AKT3 -1.06 0.32606 0.46 0.53933 mirMAP -0.38 0 NA
35 hsa-miR-663b AKT3 0.1 0.81499 0.46 0.53933 PITA -0.25 1.0E-5 NA
36 hsa-miR-769-5p AKT3 -0.31 0.7357 0.46 0.53933 PITA; miRNATAP -0.84 0 NA
37 hsa-miR-93-5p AKT3 -0.61 0.8253 0.46 0.53933 miRNATAP -0.76 0 NA
38 hsa-miR-146b-5p BRAF -0.4 0.83751 -0.04 0.94896 miRanda -0.12 0.00232 21874046; 26883911; 20406109; 21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF
39 hsa-miR-199a-5p BRAF 0.16 0.9358 -0.04 0.94896 miRanda -0.1 0.00848 NA
40 hsa-miR-199b-5p BRAF -0.04 0.97717 -0.04 0.94896 miRanda -0.12 0.0002 NA
41 hsa-miR-539-5p CAB39 0.12 0.80107 -0.14 0.92657 mirMAP -0.11 1.0E-5 NA
42 hsa-miR-155-5p CAB39L -0.41 0.82867 0.88 0.38138 miRNAWalker2 validate -0.57 0 NA
43 hsa-miR-342-3p CAB39L -0.37 0.77314 0.88 0.38138 miRanda -0.35 0.00145 NA
44 hsa-miR-582-5p CAB39L -0.4 0.58123 0.88 0.38138 miRNATAP -0.68 0 NA
45 hsa-miR-590-3p CAB39L -0.28 0.59127 0.88 0.38138 miRanda -0.33 0.00021 NA
46 hsa-miR-7-1-3p CAB39L -0.46 0.6659 0.88 0.38138 mirMAP -0.35 0.00083 NA
47 hsa-miR-101-3p DDIT4 0.01 0.99704 0.41 0.80745 miRNAWalker2 validate; MirTarget; miRNATAP -0.33 0.00086 NA
48 hsa-miR-181d-5p DDIT4 0.15 0.888 0.41 0.80745 MirTarget -0.15 0.00566 NA
49 hsa-miR-217 DDIT4 0.34 0.761 0.41 0.80745 miRanda -0.2 6.0E-5 NA
50 hsa-miR-195-5p EIF4B 0.34 0.74962 -0.02 0.99375 MirTarget; miRNATAP -0.1 0.00113 NA
51 hsa-miR-497-5p EIF4B -0.01 0.98915 -0.02 0.99375 miRNATAP -0.14 0.00012 NA
52 hsa-miR-130a-3p EIF4E 0.09 0.9291 -0.02 0.98745 mirMAP -0.12 0.00106 NA
53 hsa-miR-139-5p EIF4E -0.08 0.92869 -0.02 0.98745 miRanda -0.11 0.00314 NA
54 hsa-miR-145-5p EIF4E 0.04 0.98758 -0.02 0.98745 miRNAWalker2 validate; miRTarBase -0.13 8.0E-5 NA
55 hsa-miR-29c-3p EIF4E 0.16 0.94272 -0.02 0.98745 mirMAP -0.11 0.00551 NA
56 hsa-miR-30a-3p EIF4E 0.25 0.91709 -0.02 0.98745 mirMAP -0.13 0.00696 NA
57 hsa-miR-485-3p EIF4E -0.08 0.84013 -0.02 0.98745 MirTarget; mirMAP -0.11 0.00075 NA
58 hsa-miR-125b-5p EIF4EBP1 0.04 0.98059 -0.18 0.89152 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.14 0.00144 17891175; 26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression
59 hsa-miR-106a-5p HIF1A -0.2 0.80221 -0.18 0.90824 MirTarget -0.21 0 NA
60 hsa-miR-106b-5p HIF1A -0.3 0.86929 -0.18 0.90824 MirTarget -0.24 0 NA
61 hsa-miR-143-5p HIF1A 0.11 0.93336 -0.18 0.90824 MirTarget -0.16 9.0E-5 NA
62 hsa-miR-17-5p HIF1A -0.18 0.93454 -0.18 0.90824 miRTarBase; MirTarget; TargetScan -0.22 0 NA
63 hsa-miR-18a-5p HIF1A -0.5 0.61264 -0.18 0.90824 miRNAWalker2 validate; MirTarget -0.15 1.0E-5 25069832 Last clinically relevant correlations between miR-18a HIF1A hypoxia-responsive gene expression and distant metastasis-free survival DMFS were assessed using published expression array breast tumors data sets; We identified HIF1A as a direct target of miR-18a; Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors and that within this subtype miR-18a expression is inversely correlated with hypoxic gene expression; The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors
64 hsa-miR-18b-5p HIF1A -0.05 0.89998 -0.18 0.90824 MirTarget -0.12 0.00029 NA
65 hsa-miR-20a-5p HIF1A -0.18 0.92812 -0.18 0.90824 miRNAWalker2 validate; miRTarBase; MirTarget -0.19 0 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha
66 hsa-miR-28-5p HIF1A -0.11 0.9406 -0.18 0.90824 miRanda -0.42 0.00044 NA
67 hsa-miR-33a-5p HIF1A -0.21 0.85331 -0.18 0.90824 miRNAWalker2 validate -0.13 0 NA
68 hsa-miR-361-5p HIF1A -0.14 0.9415 -0.18 0.90824 miRanda -0.36 0 NA
69 hsa-miR-424-5p HIF1A 0.25 0.87015 -0.18 0.90824 miRNAWalker2 validate; miRTarBase -0.13 0.00059 NA
70 hsa-miR-660-5p HIF1A -0.48 0.69408 -0.18 0.90824 MirTarget -0.21 0 NA
71 hsa-miR-93-5p HIF1A -0.61 0.8253 -0.18 0.90824 MirTarget -0.14 0.00488 NA
72 hsa-let-7a-3p IGF1 -0.22 0.85543 0.01 0.98747 mirMAP -1.08 0 NA
73 hsa-let-7f-1-3p IGF1 -0.31 0.69341 0.01 0.98747 mirMAP -1.34 0 NA
74 hsa-miR-1275 IGF1 -0.83 0.08038 0.01 0.98747 MirTarget; PITA -0.38 5.0E-5 NA
75 hsa-miR-130b-3p IGF1 -0.22 0.82466 0.01 0.98747 MirTarget -1.33 0 NA
76 hsa-miR-148a-5p IGF1 -0.45 0.74842 0.01 0.98747 mirMAP -0.73 0 NA
77 hsa-miR-15b-3p IGF1 -0.56 0.60918 0.01 0.98747 mirMAP -1.37 0 NA
78 hsa-miR-16-1-3p IGF1 0.15 0.73374 0.01 0.98747 mirMAP -0.87 0 NA
79 hsa-miR-186-5p IGF1 -0.32 0.85413 0.01 0.98747 mirMAP -1.35 0 NA
80 hsa-miR-19a-3p IGF1 -0.21 0.84464 0.01 0.98747 MirTarget -0.99 0 NA
81 hsa-miR-19b-1-5p IGF1 -0.01 0.98851 0.01 0.98747 mirMAP -0.96 0 NA
82 hsa-miR-19b-3p IGF1 -0.03 0.98666 0.01 0.98747 MirTarget -1.19 0 NA
83 hsa-miR-20a-3p IGF1 0.46 0.57674 0.01 0.98747 mirMAP -0.83 0 NA
84 hsa-miR-224-3p IGF1 0.11 0.74909 0.01 0.98747 mirMAP -0.32 0.00753 NA
85 hsa-miR-26b-5p IGF1 -0.02 0.99038 0.01 0.98747 mirMAP -1.33 0 NA
86 hsa-miR-27a-3p IGF1 -0.12 0.9588 0.01 0.98747 miRNAWalker2 validate; miRTarBase -1.33 0 NA
87 hsa-miR-29a-3p IGF1 0.01 0.99698 0.01 0.98747 MirTarget -1.22 0 NA
88 hsa-miR-29b-3p IGF1 -0.1 0.95899 0.01 0.98747 MirTarget -1.13 0 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b
89 hsa-miR-301a-3p IGF1 -0.11 0.83169 0.01 0.98747 MirTarget -0.72 0 NA
90 hsa-miR-32-3p IGF1 -0.57 0.13133 0.01 0.98747 mirMAP -0.85 0 NA
91 hsa-miR-320a IGF1 -0.42 0.8402 0.01 0.98747 miRNATAP -0.53 0.00309 NA
92 hsa-miR-33a-3p IGF1 -0.79 0.01052 0.01 0.98747 MirTarget -0.71 0 NA
93 hsa-miR-361-5p IGF1 -0.14 0.9415 0.01 0.98747 PITA; mirMAP -0.76 0.00313 NA
94 hsa-miR-362-5p IGF1 -0.27 0.75202 0.01 0.98747 mirMAP -0.69 0 NA
95 hsa-miR-369-3p IGF1 0.12 0.8323 0.01 0.98747 mirMAP -0.42 0.00732 NA
96 hsa-miR-374b-3p IGF1 -0.05 0.86075 0.01 0.98747 mirMAP -0.9 0 NA
97 hsa-miR-376b-3p IGF1 -0.01 0.98243 0.01 0.98747 mirMAP -0.4 0.00219 NA
98 hsa-miR-377-3p IGF1 -0.04 0.89351 0.01 0.98747 mirMAP -0.35 0.00945 NA
99 hsa-miR-421 IGF1 -0.18 0.7347 0.01 0.98747 PITA -0.68 0 NA
100 hsa-miR-450b-5p IGF1 -0.01 0.98315 0.01 0.98747 MirTarget; PITA; mirMAP; miRNATAP -0.44 0.00527 NA
101 hsa-miR-452-5p IGF1 -0.05 0.97387 0.01 0.98747 MirTarget; mirMAP -0.39 0.00722 NA
102 hsa-miR-454-3p IGF1 -0.1 0.84355 0.01 0.98747 MirTarget -1.21 0 NA
103 hsa-miR-486-5p IGF1 -0.55 0.6964 0.01 0.98747 PITA; miRNATAP -0.28 0.00602 NA
104 hsa-miR-576-5p IGF1 -0.51 0.41719 0.01 0.98747 PITA; mirMAP; miRNATAP -1.08 0 NA
105 hsa-miR-577 IGF1 -1.06 0.32606 0.01 0.98747 PITA -0.61 0 NA
106 hsa-miR-590-3p IGF1 -0.28 0.59127 0.01 0.98747 MirTarget; miRanda; mirMAP; miRNATAP -0.9 0 NA
107 hsa-miR-592 IGF1 -0.18 0.85623 0.01 0.98747 mirMAP -0.18 0.00559 NA
108 hsa-miR-629-5p IGF1 -0.39 0.79854 0.01 0.98747 mirMAP -0.58 3.0E-5 NA
109 hsa-miR-940 IGF1 -0.23 0.68006 0.01 0.98747 MirTarget; PITA; miRNATAP -0.57 0 NA
110 hsa-miR-22-5p PDPK1 -0.08 0.9317 -0 0.99893 miRNATAP -0.11 0.00108 NA
111 hsa-miR-429 PGF -0.46 0.80624 0.25 0.74206 miRNATAP -0.16 0.0028 NA
112 hsa-let-7f-1-3p PIK3CA -0.31 0.69341 0.02 0.97942 mirMAP -0.12 0.00648 NA
113 hsa-miR-148a-5p PIK3CA -0.45 0.74842 0.02 0.97942 mirMAP -0.11 7.0E-5 NA
114 hsa-miR-148b-3p PIK3CA -0.2 0.91188 0.02 0.97942 miRNAWalker2 validate -0.12 0.00491 NA
115 hsa-miR-16-2-3p PIK3CA -0.37 0.54685 0.02 0.97942 mirMAP -0.1 9.0E-5 NA
116 hsa-miR-17-5p PIK3CA -0.18 0.93454 0.02 0.97942 miRNAWalker2 validate -0.12 0 NA
117 hsa-miR-186-5p PIK3CA -0.32 0.85413 0.02 0.97942 mirMAP -0.15 0.00027 NA
118 hsa-miR-32-3p PIK3CA -0.57 0.13133 0.02 0.97942 mirMAP -0.11 0 NA
119 hsa-miR-335-5p PIK3CA -0.03 0.97338 0.02 0.97942 miRNAWalker2 validate -0.1 0.0001 NA
120 hsa-miR-339-5p PIK3CA -0.3 0.71291 0.02 0.97942 miRanda -0.1 1.0E-5 NA
121 hsa-miR-374b-5p PIK3CA -0.29 0.8357 0.02 0.97942 mirMAP -0.14 0.00032 NA
122 hsa-miR-501-5p PIK3CA -0.83 0.05827 0.02 0.97942 mirMAP -0.11 0 NA
123 hsa-miR-576-5p PIK3CA -0.51 0.41719 0.02 0.97942 PITA -0.11 7.0E-5 NA
124 hsa-miR-582-3p PIK3CA -0.23 0.89768 0.02 0.97942 miRNATAP -0.14 0 NA
125 hsa-miR-590-3p PIK3CA -0.28 0.59127 0.02 0.97942 miRanda; mirMAP -0.12 0 NA
126 hsa-miR-590-5p PIK3CA -0.55 0.47274 0.02 0.97942 miRanda -0.14 0 NA
127 hsa-miR-96-5p PIK3CA 0.09 0.92309 0.02 0.97942 TargetScan -0.13 0 NA
128 hsa-miR-1468-5p PIK3CD -0.2 0.68841 -0.05 0.94703 MirTarget -0.29 0.00025 NA
129 hsa-miR-29a-3p PIK3CD 0.01 0.99698 -0.05 0.94703 mirMAP -0.35 0.00244 NA
130 hsa-miR-29b-3p PIK3CD -0.1 0.95899 -0.05 0.94703 mirMAP -0.26 0.00266 NA
131 hsa-miR-30b-5p PIK3CD -0.01 0.99462 -0.05 0.94703 MirTarget -0.4 0 NA
132 hsa-miR-30c-5p PIK3CD -0.3 0.86581 -0.05 0.94703 MirTarget; miRNATAP -0.42 0.00071 NA
133 hsa-miR-30d-5p PIK3CD -0.17 0.95173 -0.05 0.94703 MirTarget; miRNATAP -0.36 0.00123 NA
134 hsa-miR-421 PIK3CD -0.18 0.7347 -0.05 0.94703 miRanda -0.49 0 NA
135 hsa-miR-484 PIK3CD -0.18 0.88633 -0.05 0.94703 MirTarget; miRNATAP -0.35 0.00143 NA
136 hsa-miR-7-5p PIK3CD 0.21 0.77371 -0.05 0.94703 miRTarBase; MirTarget; miRNATAP -0.2 0.00035 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway
137 hsa-miR-942-5p PIK3CD -0.51 0.50778 -0.05 0.94703 MirTarget -0.19 0.00863 NA
138 hsa-miR-126-3p PIK3CG -0.11 0.96367 -0.36 0.46972 miRTarBase -0.53 0.00048 NA
139 hsa-miR-26b-5p PIK3CG -0.02 0.99038 -0.36 0.46972 miRNAWalker2 validate -0.8 0 NA
140 hsa-miR-29b-3p PIK3CG -0.1 0.95899 -0.36 0.46972 miRTarBase -0.67 0 NA
141 hsa-miR-335-3p PIK3CG -0.24 0.8845 -0.36 0.46972 mirMAP -0.56 0 NA
142 hsa-miR-421 PIK3CG -0.18 0.7347 -0.36 0.46972 miRanda -0.44 0.00013 NA
143 hsa-miR-502-5p PIK3CG -0.71 0.02613 -0.36 0.46972 miRNATAP -0.34 0.00065 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells
144 hsa-miR-590-3p PIK3CG -0.28 0.59127 -0.36 0.46972 miRanda -0.44 1.0E-5 NA
145 hsa-miR-132-3p PIK3R1 -0.24 0.87175 -0.11 0.93752 MirTarget -0.19 0.0073 NA
146 hsa-miR-15a-5p PIK3R1 -0.07 0.96484 -0.11 0.93752 MirTarget -0.22 9.0E-5 NA
147 hsa-miR-15b-5p PIK3R1 -0.27 0.87097 -0.11 0.93752 MirTarget -0.14 0.00644 NA
148 hsa-miR-16-5p PIK3R1 0.01 0.99448 -0.11 0.93752 MirTarget -0.19 0.00026 NA
149 hsa-miR-185-5p PIK3R1 -0.29 0.82059 -0.11 0.93752 miRNATAP -0.24 0.00027 NA
150 hsa-miR-21-5p PIK3R1 -0.15 0.97024 -0.11 0.93752 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 4.0E-5 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHORYLATION 21 1228 5.272e-18 2.453e-14
2 PROTEIN PHOSPHORYLATION 19 944 2.34e-17 5.445e-14
3 INTRACELLULAR SIGNAL TRANSDUCTION 22 1572 3.621e-17 5.616e-14
4 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 22 1977 4.584e-15 4.43e-12
5 INOSITOL LIPID MEDIATED SIGNALING 10 124 4.76e-15 4.43e-12
6 REGULATION OF PHOSPHORUS METABOLIC PROCESS 19 1618 4.382e-13 3.398e-10
7 POSITIVE REGULATION OF RESPONSE TO STIMULUS 20 1929 7.371e-13 4.9e-10
8 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 25 2.16e-12 1.256e-09
9 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 1656 9.497e-12 4.91e-09
10 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 12 498 1.099e-11 5.114e-09
11 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 74 2.808e-11 1.168e-08
12 RESPONSE TO INSULIN 9 205 3.265e-11 1.168e-08
13 NEGATIVE REGULATION OF CELL DEATH 14 872 3.058e-11 1.168e-08
14 CELLULAR RESPONSE TO HORMONE STIMULUS 12 552 3.631e-11 1.207e-08
15 CELLULAR RESPONSE TO INSULIN STIMULUS 8 146 7.91e-11 2.454e-08
16 PEPTIDYL SERINE MODIFICATION 8 148 8.823e-11 2.566e-08
17 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 1.659e-10 4.541e-08
18 REGULATION OF CELL DEATH 16 1472 2.402e-10 6.21e-08
19 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 1036 2.983e-10 6.939e-08
20 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1036 2.983e-10 6.939e-08
21 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 12 689 4.641e-10 1.028e-07
22 REGULATION OF GLUCOSE IMPORT 6 60 5.864e-10 1.24e-07
23 RESPONSE TO PEPTIDE 10 404 6.191e-10 1.245e-07
24 RESPONSE TO HORMONE 13 893 6.421e-10 1.245e-07
25 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 7 120 8.806e-10 1.639e-07
26 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.137e-09 2.035e-07
27 REGULATION OF TOR SIGNALING 6 68 1.27e-09 2.189e-07
28 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 2.492e-09 4.142e-07
29 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 13 1008 2.803e-09 4.497e-07
30 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 5 36 3.238e-09 5.022e-07
31 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 5.054e-09 7.586e-07
32 CELLULAR RESPONSE TO NITROGEN COMPOUND 10 505 5.297e-09 7.702e-07
33 RESPONSE TO NITROGEN COMPOUND 12 859 5.628e-09 7.935e-07
34 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 12 867 6.244e-09 8.545e-07
35 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 16 1848 6.723e-09 8.689e-07
36 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 6 89 6.581e-09 8.689e-07
37 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 5 42 7.254e-09 8.883e-07
38 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 5 42 7.254e-09 8.883e-07
39 CELLULAR RESPONSE TO PEPTIDE 8 274 1.156e-08 1.38e-06
40 LIPID PHOSPHORYLATION 6 99 1.254e-08 1.459e-06
41 REGULATION OF GLUCOSE TRANSPORT 6 100 1.333e-08 1.513e-06
42 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 1.439e-08 1.558e-06
43 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 17 1.439e-08 1.558e-06
44 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 5 49 1.613e-08 1.668e-06
45 REGULATION OF ATP METABOLIC PROCESS 5 49 1.613e-08 1.668e-06
46 REGULATION OF COENZYME METABOLIC PROCESS 5 50 1.79e-08 1.772e-06
47 REGULATION OF COFACTOR METABOLIC PROCESS 5 50 1.79e-08 1.772e-06
48 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 296 2.109e-08 2.044e-06
49 RESPONSE TO ENDOGENOUS STIMULUS 14 1450 2.298e-08 2.182e-06
50 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 7 193 2.414e-08 2.247e-06
51 REGULATION OF KINASE ACTIVITY 11 776 2.476e-08 2.259e-06
52 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 6 118 3.609e-08 3.229e-06
53 RESPONSE TO ABIOTIC STIMULUS 12 1024 3.974e-08 3.489e-06
54 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 4.185e-08 3.606e-06
55 LIPID MODIFICATION 7 210 4.314e-08 3.65e-06
56 GLYCEROLIPID BIOSYNTHETIC PROCESS 7 211 4.457e-08 3.703e-06
57 CELL MOTILITY 11 835 5.24e-08 4.204e-06
58 LOCALIZATION OF CELL 11 835 5.24e-08 4.204e-06
59 CELLULAR RESPONSE TO STRESS 14 1565 6.026e-08 4.753e-06
60 POSITIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 24 6.374e-08 4.862e-06
61 POSITIVE REGULATION OF ATP METABOLIC PROCESS 4 24 6.374e-08 4.862e-06
62 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 8 354 8.4e-08 6.304e-06
63 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 5 68 8.624e-08 6.369e-06
64 PHOSPHOLIPID BIOSYNTHETIC PROCESS 7 235 9.314e-08 6.771e-06
65 LOCOMOTION 12 1114 1.002e-07 7.174e-06
66 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 27 1.049e-07 7.397e-06
67 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 1135 1.229e-07 8.533e-06
68 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 12 1142 1.314e-07 8.991e-06
69 POSITIVE REGULATION OF CELL ADHESION 8 376 1.334e-07 8.994e-06
70 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 14 1672 1.379e-07 9.166e-06
71 LIPID BIOSYNTHETIC PROCESS 9 539 1.52e-07 9.959e-06
72 NEGATIVE REGULATION OF TOR SIGNALING 4 30 1.633e-07 1.055e-05
73 REGULATION OF PROTEIN MODIFICATION PROCESS 14 1710 1.824e-07 1.162e-05
74 REGULATION OF TRANSFERASE ACTIVITY 11 946 1.856e-07 1.167e-05
75 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 1.961e-07 1.217e-05
76 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 2.828e-07 1.731e-05
77 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 13 1492 2.928e-07 1.77e-05
78 POSITIVE REGULATION OF LOCOMOTION 8 420 3.101e-07 1.839e-05
79 GLUCOSE HOMEOSTASIS 6 170 3.161e-07 1.839e-05
80 CARBOHYDRATE HOMEOSTASIS 6 170 3.161e-07 1.839e-05
81 REGULATION OF LIPID METABOLIC PROCESS 7 282 3.21e-07 1.844e-05
82 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 3.448e-07 1.957e-05
83 POSITIVE REGULATION OF CELL COMMUNICATION 13 1532 3.975e-07 2.202e-05
84 RESPONSE TO EXTERNAL STIMULUS 14 1821 3.968e-07 2.202e-05
85 ANGIOGENESIS 7 293 4.156e-07 2.275e-05
86 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 4.33e-07 2.343e-05
87 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 7 297 4.553e-07 2.435e-05
88 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 5.382e-07 2.836e-05
89 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 5 98 5.425e-07 2.836e-05
90 REGULATION OF CELL ADHESION 9 629 5.577e-07 2.883e-05
91 RESPONSE TO OXYGEN LEVELS 7 311 6.205e-07 3.173e-05
92 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 6.576e-07 3.326e-05
93 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 8.776e-07 4.391e-05
94 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 12 8.913e-07 4.412e-05
95 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 6 211 1.121e-06 5.492e-05
96 REGULATION OF LIPID KINASE ACTIVITY 4 48 1.135e-06 5.502e-05
97 INDUCTION OF POSITIVE CHEMOTAXIS 3 13 1.157e-06 5.552e-05
98 REGULATION OF IMMUNE SYSTEM PROCESS 12 1403 1.203e-06 5.711e-05
99 GLYCEROLIPID METABOLIC PROCESS 7 356 1.531e-06 7.195e-05
100 REGULATED EXOCYTOSIS 6 224 1.588e-06 7.388e-05
101 PHOSPHOLIPID METABOLIC PROCESS 7 364 1.774e-06 8.094e-05
102 BLOOD VESSEL MORPHOGENESIS 7 364 1.774e-06 8.094e-05
103 REGULATION OF CELL CYCLE 10 949 1.883e-06 8.507e-05
104 REGULATION OF CATABOLIC PROCESS 9 731 1.942e-06 8.69e-05
105 TOR SIGNALING 3 16 2.259e-06 9.914e-05
106 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 16 2.259e-06 9.914e-05
107 POSITIVE REGULATION OF CELL DIVISION 5 132 2.375e-06 0.0001033
108 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 5 133 2.464e-06 0.0001062
109 REGULATION OF TRANSPORT 13 1804 2.556e-06 0.0001091
110 RESPONSE TO WOUNDING 8 563 2.798e-06 0.0001184
111 REGULATION OF AUTOPHAGY 6 249 2.93e-06 0.0001224
112 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 138 2.955e-06 0.0001224
113 CELL ACTIVATION 8 568 2.988e-06 0.0001224
114 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 2.999e-06 0.0001224
115 REGULATION OF NEURON DEATH 6 252 3.139e-06 0.000127
116 PLATELET ACTIVATION 5 142 3.4e-06 0.0001364
117 LEUKOCYTE MIGRATION 6 259 3.676e-06 0.0001462
118 T CELL RECEPTOR SIGNALING PATHWAY 5 146 3.896e-06 0.0001536
119 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 4.374e-06 0.000171
120 POSITIVE REGULATION OF CELL PROLIFERATION 9 814 4.687e-06 0.0001817
121 REGULATION OF CELL DIVISION 6 272 4.872e-06 0.0001873
122 RESPONSE TO ACTIVITY 4 69 4.922e-06 0.0001877
123 CELL CYCLE ARREST 5 154 5.058e-06 0.0001913
124 POSITIVE REGULATION OF NEUROBLAST PROLIFERATION 3 21 5.334e-06 0.0002002
125 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 8 616 5.436e-06 0.0002008
126 RESPONSE TO DRUG 7 431 5.41e-06 0.0002008
127 ACTIVATION OF PROTEIN KINASE ACTIVITY 6 279 5.636e-06 0.0002065
128 RESPONSE TO PURINE CONTAINING COMPOUND 5 158 5.732e-06 0.0002084
129 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 162 6.476e-06 0.0002336
130 REGULATION OF GROWTH 8 633 6.638e-06 0.0002376
131 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 4 75 6.872e-06 0.0002404
132 CELLULAR GLUCOSE HOMEOSTASIS 4 75 6.872e-06 0.0002404
133 POSITIVE REGULATION OF AUTOPHAGY 4 75 6.872e-06 0.0002404
134 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 7 448 6.967e-06 0.0002419
135 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 23 7.087e-06 0.0002443
136 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 7 450 7.173e-06 0.0002454
137 LYMPHOCYTE COSTIMULATION 4 78 8.037e-06 0.0002728
138 REGULATION OF POSITIVE CHEMOTAXIS 3 24 8.09e-06 0.0002728
139 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 11 1395 8.441e-06 0.0002804
140 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 876 8.496e-06 0.0002804
141 NEGATIVE REGULATION OF NEURON DEATH 5 171 8.425e-06 0.0002804
142 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 8.667e-06 0.000284
143 REGULATION OF MAPK CASCADE 8 660 9.009e-06 0.0002931
144 VASCULATURE DEVELOPMENT 7 469 9.392e-06 0.0003014
145 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 9.342e-06 0.0003014
146 POSITIVE REGULATION OF MAPK CASCADE 7 470 9.523e-06 0.0003014
147 WOUND HEALING 7 470 9.523e-06 0.0003014
148 EXOCYTOSIS 6 310 1.028e-05 0.0003234
149 POSITIVE REGULATION OF CELL ACTIVATION 6 311 1.048e-05 0.0003271
150 POSITIVE REGULATION OF GENE EXPRESSION 12 1733 1.088e-05 0.0003376
151 CELLULAR LIPID METABOLIC PROCESS 9 913 1.185e-05 0.0003652
152 REGULATION OF NEUROBLAST PROLIFERATION 3 28 1.304e-05 0.000399
153 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 9 926 1.327e-05 0.0004037
154 REGULATION OF RESPONSE TO STRESS 11 1468 1.371e-05 0.0004143
155 POSITIVE REGULATION OF MOLECULAR FUNCTION 12 1791 1.523e-05 0.0004571
156 REGULATION OF BODY FLUID LEVELS 7 506 1.536e-05 0.0004583
157 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 5 195 1.591e-05 0.0004707
158 REGULATION OF CELL DIFFERENTIATION 11 1492 1.598e-05 0.0004707
159 REGULATION OF CELL PROLIFERATION 11 1496 1.639e-05 0.0004797
160 POSITIVE REGULATION OF CATALYTIC ACTIVITY 11 1518 1.881e-05 0.000547
161 PROTEIN KINASE B SIGNALING 3 34 2.365e-05 0.0006835
162 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 213 2.433e-05 0.0006989
163 CELL DEATH 9 1001 2.468e-05 0.0007044
164 CIRCULATORY SYSTEM PROCESS 6 366 2.629e-05 0.000746
165 PLATELET DEGRANULATION 4 107 2.812e-05 0.0007892
166 POSITIVE CHEMOTAXIS 3 36 2.816e-05 0.0007892
167 CARDIOVASCULAR SYSTEM DEVELOPMENT 8 788 3.239e-05 0.000897
168 CIRCULATORY SYSTEM DEVELOPMENT 8 788 3.239e-05 0.000897
169 CELL CYCLE 10 1316 3.363e-05 0.0009259
170 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 229 3.442e-05 0.0009421
171 REGULATION OF VASCULATURE DEVELOPMENT 5 233 3.739e-05 0.001017
172 AUTOPHAGY 6 394 3.972e-05 0.001075
173 SECRETION 7 588 4.023e-05 0.001082
174 POSITIVE REGULATION OF GROWTH 5 238 4.137e-05 0.001106
175 IMMUNE SYSTEM PROCESS 12 1984 4.263e-05 0.001134
176 POSITIVE REGULATION OF CELL DIFFERENTIATION 8 823 4.413e-05 0.001167
177 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 42 4.497e-05 0.001182
178 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 4.567e-05 0.001187
179 REGULATION OF PROTEIN KINASE B SIGNALING 4 121 4.554e-05 0.001187
180 RESPONSE TO ELECTRICAL STIMULUS 3 43 4.828e-05 0.001248
181 POSITIVE REGULATION OF MITOTIC CELL CYCLE 4 123 4.855e-05 0.001248
182 REGULATION OF CELL DEVELOPMENT 8 836 4.931e-05 0.001261
183 PEPTIDYL AMINO ACID MODIFICATION 8 841 5.144e-05 0.001308
184 ACTIVATION OF IMMUNE RESPONSE 6 427 6.211e-05 0.001571
185 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 4 133 6.585e-05 0.001647
186 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 4 133 6.585e-05 0.001647
187 CHEMICAL HOMEOSTASIS 8 874 6.749e-05 0.001653
188 POSITIVE REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 3 48 6.729e-05 0.001653
189 NEGATIVE REGULATION OF CELL CYCLE 6 433 6.71e-05 0.001653
190 POSITIVE REGULATION OF RESPONSE TO NUTRIENT LEVELS 3 48 6.729e-05 0.001653
191 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 135 6.979e-05 0.0017
192 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 7.424e-05 0.001799
193 LIPID METABOLIC PROCESS 9 1158 7.718e-05 0.001861
194 FC EPSILON RECEPTOR SIGNALING PATHWAY 4 142 8.493e-05 0.002037
195 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 8.727e-05 0.002082
196 MACROAUTOPHAGY 5 281 9.085e-05 0.002157
197 NEGATIVE REGULATION OF CELL COMMUNICATION 9 1192 9.647e-05 0.002279
198 POSITIVE REGULATION OF CELL GROWTH 4 148 9.97e-05 0.002343
199 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 55 0.0001013 0.002368
200 REGULATION OF DEVELOPMENTAL GROWTH 5 289 0.0001037 0.0024
201 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 289 0.0001037 0.0024
202 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 470 0.0001054 0.002428
203 POSITIVE REGULATION OF TRANSPORT 8 936 0.000109 0.002499
204 RESPONSE TO STARVATION 4 154 0.0001163 0.002652
205 REGULATION OF CELL ACTIVATION 6 484 0.0001238 0.002809
206 SECRETION BY CELL 6 486 0.0001266 0.002845
207 IMMUNE EFFECTOR PROCESS 6 486 0.0001266 0.002845
208 VESICLE MEDIATED TRANSPORT 9 1239 0.0001297 0.002902
209 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001314 0.002924
210 REGULATION OF HOMOTYPIC CELL CELL ADHESION 5 307 0.0001376 0.003043
211 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.000138 0.003043
212 POSITIVE REGULATION OF VASCULAR PERMEABILITY 2 11 0.0001439 0.003158
213 HEMOSTASIS 5 311 0.0001462 0.003193
214 RESPONSE TO OSMOTIC STRESS 3 63 0.0001519 0.003303
215 REGULATION OF EPITHELIAL CELL MIGRATION 4 166 0.0001552 0.003359
216 RESPONSE TO CARBOHYDRATE 4 168 0.0001625 0.003501
217 REGULATION OF MAP KINASE ACTIVITY 5 319 0.0001645 0.003528
218 FATTY ACID HOMEOSTASIS 2 12 0.0001725 0.003664
219 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 6 514 0.0001717 0.003664
220 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 323 0.0001744 0.003688
221 REGULATION OF CELL SUBSTRATE ADHESION 4 173 0.0001819 0.003824
222 CELLULAR RESPONSE TO DRUG 3 67 0.0001824 0.003824
223 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 750 0.0001846 0.003852
224 REGULATION OF CELLULAR COMPONENT BIOGENESIS 7 767 0.0002119 0.004402
225 SINGLE ORGANISM BIOSYNTHETIC PROCESS 9 1340 0.0002349 0.0048
226 CELLULAR RESPONSE TO ELECTRICAL STIMULUS 2 14 0.0002373 0.0048
227 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0002373 0.0048
228 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0002373 0.0048
229 T CELL MIGRATION 2 14 0.0002373 0.0048
230 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 73 0.0002353 0.0048
231 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 3 74 0.0002449 0.004934
232 GRANULOCYTE MIGRATION 3 75 0.0002549 0.005112
233 REGULATION OF NEURON APOPTOTIC PROCESS 4 192 0.0002709 0.00541
234 RESPIRATORY BURST 2 15 0.0002735 0.005439
235 DEVELOPMENTAL MATURATION 4 193 0.0002763 0.005471
236 POSITIVE REGULATION OF IMMUNE RESPONSE 6 563 0.0002808 0.005536
237 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 5 360 0.0002881 0.005656
238 CELL CYCLE PROCESS 8 1081 0.0002935 0.005737
239 RESPONSE TO ALCOHOL 5 362 0.0002956 0.005754
240 ERBB SIGNALING PATHWAY 3 79 0.0002971 0.005761
241 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 8 1087 0.0003047 0.005882
242 POSITIVE REGULATION OF LEUKOCYTE CHEMOTAXIS 3 81 0.0003199 0.00615
243 NEUROGENESIS 9 1402 0.0003294 0.006307
244 REGULATION OF TRANSLATIONAL INITIATION 3 82 0.0003316 0.006324
245 REGULATION OF ENERGY HOMEOSTASIS 2 17 0.0003535 0.006641
246 FC RECEPTOR SIGNALING PATHWAY 4 206 0.0003539 0.006641
247 MAMMARY GLAND ALVEOLUS DEVELOPMENT 2 17 0.0003535 0.006641
248 MAMMARY GLAND LOBULE DEVELOPMENT 2 17 0.0003535 0.006641
249 POSITIVE REGULATION OF MAP KINASE ACTIVITY 4 207 0.0003605 0.006737
250 REGULATION OF CELL CELL ADHESION 5 380 0.0003693 0.006847
251 HEART PROCESS 3 85 0.0003686 0.006847
252 SINGLE ORGANISM BEHAVIOR 5 384 0.0003875 0.007155
253 CELLULAR RESPONSE TO PROSTAGLANDIN E STIMULUS 2 18 0.0003973 0.00725
254 RESPONSE TO CAFFEINE 2 18 0.0003973 0.00725
255 MAST CELL MEDIATED IMMUNITY 2 18 0.0003973 0.00725
256 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 3 88 0.0004082 0.007362
257 REGULATION OF STEM CELL PROLIFERATION 3 88 0.0004082 0.007362
258 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 3 88 0.0004082 0.007362
259 REGULATION OF CELL GROWTH 5 391 0.0004208 0.007561
260 REGULATION OF CELL MATRIX ADHESION 3 90 0.000436 0.007803
261 POSITIVE REGULATION OF CATABOLIC PROCESS 5 395 0.0004409 0.00783
262 GLAND DEVELOPMENT 5 395 0.0004409 0.00783
263 REGULATION OF TRANSLATION IN RESPONSE TO STRESS 2 19 0.0004436 0.007848
264 EMBRYONIC HEMOPOIESIS 2 20 0.0004924 0.008645
265 RESPONSE TO MUSCLE ACTIVITY 2 20 0.0004924 0.008645
266 ORGANOPHOSPHATE METABOLIC PROCESS 7 885 0.0005049 0.008833
267 FC GAMMA RECEPTOR SIGNALING PATHWAY 3 95 0.0005108 0.008902
268 REGULATION OF LEUKOCYTE CHEMOTAXIS 3 96 0.0005267 0.009145
269 MAST CELL ACTIVATION 2 21 0.0005437 0.009369
270 NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS 2 21 0.0005437 0.009369
271 MYELOID LEUKOCYTE MIGRATION 3 99 0.0005763 0.009822
272 STRIATED MUSCLE CONTRACTION 3 99 0.0005763 0.009822
273 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 3 99 0.0005763 0.009822
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 20 842 8.388e-20 7.793e-17
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 20 992 2.092e-18 9.718e-16
3 PROTEIN SERINE THREONINE KINASE ACTIVITY 15 445 9.23e-17 2.858e-14
4 PROTEIN KINASE ACTIVITY 15 640 1.955e-14 4.54e-12
5 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 1.879e-11 3.491e-09
6 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 7.283e-11 1.128e-08
7 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 6 51 2.132e-10 2.829e-08
8 ADENYL NUCLEOTIDE BINDING 15 1514 4.034e-09 4.684e-07
9 RIBONUCLEOTIDE BINDING 16 1860 7.382e-09 7.62e-07
10 KINASE BINDING 10 606 2.989e-08 2.777e-06
11 ENZYME BINDING 14 1737 2.215e-07 1.87e-05
12 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 4 39 4.849e-07 3.754e-05
13 KINASE REGULATOR ACTIVITY 6 186 5.364e-07 3.834e-05
14 ENZYME REGULATOR ACTIVITY 10 959 2.07e-06 0.0001373
15 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 2.259e-06 0.0001399
16 GROWTH FACTOR ACTIVITY 5 160 6.095e-06 0.0003442
17 MOLECULAR FUNCTION REGULATOR 11 1353 6.298e-06 0.0003442
18 PROTEIN HETERODIMERIZATION ACTIVITY 7 468 9.262e-06 0.000478
19 CHEMOATTRACTANT ACTIVITY 3 27 1.165e-05 0.0005697
20 INSULIN RECEPTOR BINDING 3 32 1.965e-05 0.0009126
21 PROTEIN PHOSPHATASE BINDING 4 120 4.408e-05 0.00195
22 MACROMOLECULAR COMPLEX BINDING 10 1399 5.67e-05 0.002394
23 RECEPTOR BINDING 10 1476 8.916e-05 0.003601
24 PHOSPHATASE BINDING 4 162 0.0001413 0.005346
25 INSULIN RECEPTOR SUBSTRATE BINDING 2 11 0.0001439 0.005346
26 INSULIN LIKE GROWTH FACTOR RECEPTOR BINDING 2 15 0.0002735 0.009773
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 1.286e-15 7.511e-13
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 11 237 7.889e-14 2.304e-11
3 EXTRINSIC COMPONENT OF MEMBRANE 8 252 6.012e-09 1.17e-06
4 TRANSFERASE COMPLEX 11 703 8.943e-09 1.306e-06
5 CATALYTIC COMPLEX 11 1038 4.703e-07 5.493e-05
6 PLATELET ALPHA GRANULE LUMEN 4 55 1.974e-06 0.0001921
7 PLATELET ALPHA GRANULE 4 75 6.872e-06 0.0005734
8 SECRETORY GRANULE LUMEN 4 85 1.132e-05 0.0008261
9 PROTEIN KINASE COMPLEX 4 90 1.42e-05 0.0009213
10 VESICLE LUMEN 4 106 2.71e-05 0.001582

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04150_mTOR_signaling_pathway 33 52 7.926e-92 1.427e-89
2 hsa04151_PI3K_AKT_signaling_pathway 22 351 1.987e-31 1.788e-29
3 hsa04910_Insulin_signaling_pathway 16 138 1.138e-26 6.826e-25
4 hsa04914_Progesterone.mediated_oocyte_maturation 14 87 2.218e-25 9.983e-24
5 hsa04510_Focal_adhesion 15 200 5.203e-22 1.873e-20
6 hsa04722_Neurotrophin_signaling_pathway 13 127 7.481e-21 2.244e-19
7 hsa04012_ErbB_signaling_pathway 11 87 9.81e-19 2.523e-17
8 hsa04960_Aldosterone.regulated_sodium_reabsorption 9 42 1.178e-17 2.651e-16
9 hsa04370_VEGF_signaling_pathway 9 76 3.628e-15 6.712e-14
10 hsa04973_Carbohydrate_digestion_and_absorption 8 44 3.729e-15 6.712e-14
11 hsa04666_Fc_gamma_R.mediated_phagocytosis 9 95 2.932e-14 4.797e-13
12 hsa04014_Ras_signaling_pathway 11 236 7.531e-14 1.13e-12
13 hsa04662_B_cell_receptor_signaling_pathway 8 75 3.429e-13 4.748e-12
14 hsa04664_Fc_epsilon_RI_signaling_pathway 8 79 5.279e-13 6.787e-12
15 hsa04210_Apoptosis 8 89 1.413e-12 1.696e-11
16 hsa04620_Toll.like_receptor_signaling_pathway 8 102 4.325e-12 4.865e-11
17 hsa04660_T_cell_receptor_signaling_pathway 8 108 6.896e-12 7.302e-11
18 hsa04062_Chemokine_signaling_pathway 9 189 1.574e-11 1.574e-10
19 hsa04380_Osteoclast_differentiation 8 128 2.739e-11 2.595e-10
20 hsa04070_Phosphatidylinositol_signaling_system 7 78 4.103e-11 3.693e-10
21 hsa04650_Natural_killer_cell_mediated_cytotoxicity 8 136 4.468e-11 3.83e-10
22 hsa04630_Jak.STAT_signaling_pathway 8 155 1.278e-10 1.046e-09
23 hsa04670_Leukocyte_transendothelial_migration 7 117 7.367e-10 5.765e-09
24 hsa04810_Regulation_of_actin_cytoskeleton 8 214 1.663e-09 1.247e-08
25 hsa04720_Long.term_potentiation 5 70 9.989e-08 7.192e-07
26 hsa04140_Regulation_of_autophagy 4 34 2.75e-07 1.904e-06
27 hsa04114_Oocyte_meiosis 5 114 1.151e-06 7.673e-06
28 hsa04010_MAPK_signaling_pathway 6 268 4.474e-06 2.876e-05
29 hsa00562_Inositol_phosphate_metabolism 3 57 0.0001127 0.0006995
30 hsa04920_Adipocytokine_signaling_pathway 3 68 0.0001906 0.001144
31 hsa03013_RNA_transport 3 152 0.001987 0.01154
32 hsa04730_Long.term_depression 2 70 0.005944 0.03344

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-130b-3p;hsa-miR-148a-5p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-374b-3p;hsa-miR-421;hsa-miR-452-5p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-592;hsa-miR-629-5p;hsa-miR-940 29 IGF1 Sponge network 1.057 0.31716 0.009 0.98747 0.587
2

EMX2OS

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-663b;hsa-miR-93-5p 25 AKT3 Sponge network 1.057 0.31716 0.457 0.53933 0.542
3

CECR7

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-1275;hsa-miR-130b-3p;hsa-miR-148a-5p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-361-5p;hsa-miR-362-5p;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-592;hsa-miR-629-5p 24 IGF1 Sponge network 0.551 0.56177 0.009 0.98747 0.513
4

CECR7

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1275;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-93-5p 20 AKT3 Sponge network 0.551 0.56177 0.457 0.53933 0.508
5

MEG3

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-93-5p 12 AKT3 Sponge network 0.433 0.33816 0.457 0.53933 0.405
6

MEG3

 hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-186-5p;hsa-miR-20a-3p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-374b-3p;hsa-miR-576-5p;hsa-miR-577 10 IGF1 Sponge network 0.433 0.33816 0.009 0.98747 0.37
7

CECR7

 hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-590-5p 11 PIK3CA Sponge network 0.551 0.56177 0.023 0.97942 0.368
8

CECR7

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-let-7g-5p;hsa-miR-106b-5p;hsa-miR-10a-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-32-3p;hsa-miR-331-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-93-5p 30 PRKAA2 Sponge network 0.551 0.56177 1.352 0.06117 0.309
9

ZNF883

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-33a-3p 10 AKT3 Sponge network 0.913 0.16772 0.457 0.53933 0.3
10

EMX2OS

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-let-7g-5p;hsa-miR-106b-5p;hsa-miR-10a-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-146a-5p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-32-3p;hsa-miR-331-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-93-5p 32 PRKAA2 Sponge network 1.057 0.31716 1.352 0.06117 0.292
11

EMX2OS

 hsa-miR-130b-5p;hsa-miR-17-5p;hsa-miR-192-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-21-3p;hsa-miR-26b-5p;hsa-miR-335-5p;hsa-miR-378a-3p;hsa-miR-532-3p;hsa-miR-592;hsa-miR-760;hsa-miR-93-3p 15 RPS6KA2 Sponge network 1.057 0.31716 0.145 0.89703 0.27
12

ZNF883

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-130b-3p;hsa-miR-148a-5p;hsa-miR-15b-3p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-33a-3p;hsa-miR-576-5p 15 IGF1 Sponge network 0.913 0.16772 0.009 0.98747 0.269
13 HCG11 hsa-let-7d-5p;hsa-let-7g-5p;hsa-miR-10a-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-146a-5p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-21-3p;hsa-miR-26a-1-3p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-7-1-3p 15 PRKAA2 Sponge network 0.419 0.63279 1.352 0.06117 0.258
14

CECR7

 hsa-miR-130b-5p;hsa-miR-17-5p;hsa-miR-192-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-26b-5p;hsa-miR-335-5p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-592;hsa-miR-760 14 RPS6KA2 Sponge network 0.551 0.56177 0.145 0.89703 0.258
15

EMX2OS

 hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-576-5p;hsa-miR-582-3p;hsa-miR-590-3p 13 PIK3CA Sponge network 1.057 0.31716 0.023 0.97942 0.254
16 DGCR5 hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-146a-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-30e-3p;hsa-miR-33a-3p;hsa-miR-576-5p 12 PRKAA2 Sponge network 0.256 0.70355 1.352 0.06117 0.251

Quest ID: be8aab85fc917f3cee3dc78658df4fea