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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p AIFM1 -0.03 0.99135 0.27 0.86957 miRanda -0.21 0.00378 NA
2 hsa-miR-125b-5p AIFM1 -0.05 0.98663 0.27 0.86957 miRNATAP -0.11 0.01066 NA
3 hsa-miR-143-5p AIFM1 -0.16 0.7483 0.27 0.86957 miRNATAP -0.1 0.00577 NA
4 hsa-miR-145-5p AIFM1 0.45 0.85887 0.27 0.86957 miRNATAP -0.13 0.00193 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death
5 hsa-miR-125b-5p AKT1 -0.05 0.98663 0.07 0.97165 miRNAWalker2 validate; miRTarBase -0.08 0.02901 NA
6 hsa-miR-214-3p AKT2 0.16 0.89332 0.09 0.96336 mirMAP -0.06 0.02475 NA
7 hsa-miR-29a-3p AKT2 0.62 0.84783 0.09 0.96336 MirTarget -0.12 0.00214 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis
8 hsa-miR-326 AKT2 0.23 0.8973 0.09 0.96336 miRanda -0.07 0.01518 NA
9 hsa-miR-106a-5p AKT3 -0.83 0.17315 0.03 0.97698 miRNATAP -0.16 0.00858 NA
10 hsa-miR-106b-5p AKT3 -0.33 0.77865 0.03 0.97698 miRNATAP -0.31 0.00102 NA
11 hsa-miR-107 AKT3 -0.25 0.93044 0.03 0.97698 PITA; miRanda -0.29 0.00414 NA
12 hsa-miR-335-3p AKT3 0.01 0.99209 0.03 0.97698 mirMAP -0.16 0.00961 NA
13 hsa-miR-93-5p AKT3 -0.48 0.87936 0.03 0.97698 miRNATAP -0.27 0.00266 NA
14 hsa-miR-23b-3p APAF1 0.45 0.87144 0.22 0.83716 miRNATAP -0.1 0.00576 NA
15 hsa-miR-27b-3p APAF1 0.5 0.84374 0.22 0.83716 miRNATAP -0.09 0.01948 NA
16 hsa-miR-502-3p APAF1 0.09 0.93326 0.22 0.83716 miRNATAP -0.08 0.02252 NA
17 hsa-miR-504-5p BAX -0.37 0.64011 -0.01 0.99532 miRNAWalker2 validate -0.07 0.00011 NA
18 hsa-let-7a-5p BCL2 0.31 0.9388 -0.12 0.89721 miRNAWalker2 validate -0.16 0.048 24643702; 26915294 Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl 2 via microRNA let 7a and miR 34b in ovarian cancer cells; Moreover the relative abundance of Bcl-2 and microRNAs let-7a miR-34b expressions were detected by quantitative real-time PCR qRT-PCR and Western blotting; E2 + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells; When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors E2 + P4 treatment did not change the protein level of Bcl-2; E2 + P4 significantly inhibited the cell survival promoted the cell apoptosis induced the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively
19 hsa-miR-15b-3p BCL2 0.16 0.87385 -0.12 0.89721 mirMAP -0.19 0.00394 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
20 hsa-miR-15b-5p BCL2 0.29 0.91486 -0.12 0.89721 miRNAWalker2 validate; miRTarBase -0.22 0.00768 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
21 hsa-miR-192-5p BCL2 0.21 0.89254 -0.12 0.89721 miRNAWalker2 validate -0.12 0.01734 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
22 hsa-miR-196b-5p BCL2 0.62 0.60417 -0.12 0.89721 miRNAWalker2 validate -0.07 0.00367 NA
23 hsa-miR-21-5p BCL2 -0.18 0.95096 -0.12 0.89721 miRNAWalker2 validate; miRTarBase -0.15 0.00126 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
24 hsa-miR-224-5p BCL2 0.03 0.9816 -0.12 0.89721 mirMAP -0.07 0.0329 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
25 hsa-miR-326 BCL2L1 0.23 0.8973 0.22 0.91107 PITA; miRanda; mirMAP; miRNATAP -0.06 0.00781 NA
26 hsa-miR-505-5p BCL2L1 -0 0.99846 0.22 0.91107 miRNATAP -0.09 0.01867 NA
27 hsa-miR-940 BCL2L1 0.18 0.86941 0.22 0.91107 mirMAP -0.06 0.0153 NA
28 hsa-miR-129-5p BIRC3 0.34 0.79155 0.57 0.53893 miRanda -0.22 0.00017 NA
29 hsa-miR-107 CAPN2 -0.25 0.93044 -0.03 0.9893 miRanda -0.16 0.00224 NA
30 hsa-miR-129-5p CAPN2 0.34 0.79155 -0.03 0.9893 miRanda -0.06 0.01789 NA
31 hsa-miR-129-5p CASP10 0.34 0.79155 0.24 0.83416 mirMAP -0.09 0.029 NA
32 hsa-let-7b-5p CASP3 0.61 0.88157 0.01 0.99146 MirTarget; miRNATAP -0.07 0.03025 NA
33 hsa-let-7c-5p CASP3 -0.05 0.98806 0.01 0.99146 MirTarget -0.1 0.00027 NA
34 hsa-let-7g-5p CASP3 -0.03 0.98708 0.01 0.99146 MirTarget; miRNATAP -0.08 0.01489 NA
35 hsa-miR-101-3p CASP3 0.33 0.85185 0.01 0.99146 MirTarget -0.14 7.0E-5 NA
36 hsa-miR-30a-5p CASP3 0.24 0.93548 0.01 0.99146 miRNATAP -0.1 0.00039 NA
37 hsa-miR-30c-5p CASP3 -0.08 0.9735 0.01 0.99146 miRNATAP -0.14 0.00033 NA
38 hsa-miR-30d-5p CASP3 0.08 0.98196 0.01 0.99146 miRNAWalker2 validate; miRTarBase; miRNATAP -0.1 0.01256 NA
39 hsa-miR-320c CASP3 0.27 0.6737 0.01 0.99146 MirTarget; miRanda -0.1 0.00087 NA
40 hsa-miR-320d CASP3 0.84 0.1588 0.01 0.99146 MirTarget; miRanda -0.08 0.0007 NA
41 hsa-miR-125a-5p CASP6 -0.03 0.99135 -0.12 0.91669 miRanda -0.15 0.0371 NA
42 hsa-miR-106b-5p CASP7 -0.33 0.77865 0.5 0.68408 miRNAWalker2 validate -0.15 0.00046 22986525 MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited
43 hsa-miR-18a-3p CASP7 -0.35 0.70816 0.5 0.68408 MirTarget -0.12 0.00095 NA
44 hsa-miR-125a-3p CASP9 0.23 0.8631 -0.21 0.84201 miRanda -0.19 3.0E-5 NA
45 hsa-miR-133a-3p CASP9 0.25 0.71221 -0.21 0.84201 miRNAWalker2 validate; miRTarBase -0.07 0.00201 NA
46 hsa-miR-193b-3p CASP9 0.13 0.9464 -0.21 0.84201 miRNAWalker2 validate -0.09 0.00595 NA
47 hsa-miR-199a-3p CASP9 0.34 0.86114 -0.21 0.84201 mirMAP -0.09 0.00065 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol
48 hsa-miR-199b-3p CASP9 0.34 0.86123 -0.21 0.84201 mirMAP -0.09 0.00065 NA
49 hsa-miR-342-5p CASP9 -0.22 0.83785 -0.21 0.84201 MirTarget -0.17 3.0E-5 NA
50 hsa-miR-1275 CFLAR 0.94 0.34521 -0.21 0.87646 MirTarget -0.05 0.01314 NA
51 hsa-miR-20a-5p CHP2 -0.89 0.40574 -0.33 0.73035 MirTarget -0.33 0.01146 NA
52 hsa-miR-23b-3p CHUK 0.45 0.87144 0.12 0.91277 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.07 0.04069 NA
53 hsa-miR-181c-5p CSF2RB -0.3 0.84148 -0.34 0.65307 MirTarget -0.19 0.00892 NA
54 hsa-miR-320c CYCS 0.27 0.6737 0.21 0.90854 miRNAWalker2 validate -0.09 0.01208 NA
55 hsa-miR-361-5p CYCS -0.28 0.90427 0.21 0.90854 miRNAWalker2 validate -0.16 0.01243 NA
56 hsa-let-7b-5p DFFA 0.61 0.88157 -0.16 0.91073 miRNAWalker2 validate -0.09 0.0053 NA
57 hsa-miR-1228-3p DFFA 0.28 0.67297 -0.16 0.91073 mirMAP -0.09 0.00172 NA
58 hsa-miR-127-3p DFFA 0.09 0.9754 -0.16 0.91073 miRanda -0.08 0.00073 NA
59 hsa-miR-145-5p DFFA 0.45 0.85887 -0.16 0.91073 miRNAWalker2 validate; miRTarBase -0.14 1.0E-5 NA
60 hsa-miR-342-3p DFFA -0.13 0.9464 -0.16 0.91073 mirMAP -0.14 0.00044 NA
61 hsa-miR-377-5p DFFA 0.36 0.70661 -0.16 0.91073 mirMAP -0.08 0.00021 NA
62 hsa-miR-409-3p DFFA 0.12 0.93349 -0.16 0.91073 mirMAP -0.07 0.00639 NA
63 hsa-miR-432-5p DFFA -0.15 0.90301 -0.16 0.91073 mirMAP -0.06 0.00266 NA
64 hsa-miR-365a-3p DFFB 0.32 0.85542 -0.15 0.85373 MirTarget -0.12 0.00828 NA
65 hsa-miR-130b-3p ENDOD1 -0.51 0.60668 0.65 0.66039 MirTarget -0.21 9.0E-5 NA
66 hsa-miR-181a-5p ENDOD1 -0.29 0.9241 0.65 0.66039 MirTarget -0.15 0.00642 NA
67 hsa-miR-181b-5p ENDOD1 -0.28 0.90498 0.65 0.66039 MirTarget -0.18 0.00081 NA
68 hsa-miR-181c-5p ENDOD1 -0.3 0.84148 0.65 0.66039 MirTarget -0.09 0.04415 NA
69 hsa-miR-181d-5p ENDOD1 -0.36 0.80299 0.65 0.66039 MirTarget -0.11 0.00565 NA
70 hsa-miR-335-3p ENDOD1 0.01 0.99209 0.65 0.66039 MirTarget -0.08 0.04196 NA
71 hsa-miR-26b-5p ENDOG 0.38 0.81911 0.05 0.96135 miRNAWalker2 validate -0.14 0.01892 NA
72 hsa-miR-1275 EXOG 0.94 0.34521 -0.18 0.80092 MirTarget -0.06 0.00344 NA
73 hsa-miR-200b-3p EXOG -0.35 0.8855 -0.18 0.80092 MirTarget -0.05 0.04064 NA
74 hsa-miR-200c-3p EXOG -0.62 0.88052 -0.18 0.80092 MirTarget -0.07 0.0074 NA
75 hsa-miR-129-5p FADD 0.34 0.79155 0.14 0.91436 miRanda -0.06 0.00034 NA
76 hsa-miR-28-5p FADD 0.2 0.86472 0.14 0.91436 miRanda -0.08 0.02127 NA
77 hsa-miR-361-5p FADD -0.28 0.90427 0.14 0.91436 MirTarget; miRanda; miRNATAP -0.15 0.00056 NA
78 hsa-miR-129-5p FAS 0.34 0.79155 0.27 0.80534 miRanda -0.12 0.00037 NA
79 hsa-miR-338-3p FAS -0.15 0.87896 0.27 0.80534 miRanda -0.08 0.02568 NA
80 hsa-miR-324-5p FASLG -0.1 0.93932 -0.34 0.61443 miRanda -0.26 0.04241 NA
81 hsa-miR-92a-3p FASLG -0.38 0.92886 -0.34 0.61443 miRNATAP -0.47 0.00193 NA
82 hsa-miR-92b-3p FASLG -0.04 0.98973 -0.34 0.61443 miRNATAP -0.27 0.00726 NA
83 hsa-miR-139-5p IKBKB 0.32 0.82796 -0.2 0.88542 miRanda -0.11 0.00111 NA
84 hsa-miR-199a-5p IKBKB 0.39 0.84403 -0.2 0.88542 miRNAWalker2 validate; miRTarBase; miRanda; miRNATAP -0.08 0.00299 NA
85 hsa-miR-320c IKBKG 0.27 0.6737 0 0.99944 mirMAP -0.06 0.0233 NA
86 hsa-miR-125a-3p IL1A 0.23 0.8631 -0.66 0.25694 miRanda -0.3 0.01538 NA
87 hsa-miR-296-3p IL1B -0.11 0.90124 -0.39 0.62447 miRNATAP -0.15 0.02531 NA
88 hsa-miR-30a-3p IL1B 0.46 0.885 -0.39 0.62447 MirTarget -0.21 0.01107 NA
89 hsa-miR-129-5p IL1RAP 0.34 0.79155 0.25 0.86742 miRanda -0.11 0.00324 NA
90 hsa-miR-375 IL1RAP -1.76 0.51496 0.25 0.86742 miRNAWalker2 validate; miRanda -0.09 0.00229 NA
91 hsa-miR-93-5p IL1RAP -0.48 0.87936 0.25 0.86742 MirTarget -0.13 0.04658 NA
92 hsa-miR-1226-3p IRAK1 -0.04 0.97781 -0.06 0.97425 miRNAWalker2 validate -0.11 0.00112 NA
93 hsa-miR-149-5p IRAK1 0.02 0.99274 -0.06 0.97425 mirMAP -0.09 0.00264 NA
94 hsa-miR-92a-3p IRAK1 -0.38 0.92886 -0.06 0.97425 miRNAWalker2 validate -0.16 0.00421 NA
95 hsa-miR-335-3p IRAK3 0.01 0.99209 -0.18 0.79856 mirMAP -0.1 0.03752 NA
96 hsa-miR-320b IRAK4 0.5 0.81377 0.18 0.86729 miRanda -0.06 0.01678 NA
97 hsa-miR-320d IRAK4 0.84 0.1588 0.18 0.86729 miRanda -0.05 0.01164 NA
98 hsa-miR-331-3p MAP3K14 -0.11 0.94441 -0.13 0.89776 MirTarget -0.07 0.04838 NA
99 hsa-miR-129-5p NFKB1 0.34 0.79155 0.24 0.86694 PITA; miRanda -0.11 1.0E-5 NA
100 hsa-miR-92a-3p NFKB1 -0.38 0.92886 0.24 0.86694 miRNAWalker2 validate -0.1 0.04839 NA
101 hsa-let-7d-5p NGF 0.36 0.87121 0.11 0.82029 MirTarget -0.39 7.0E-5 NA
102 hsa-let-7f-5p NGF 0.24 0.93055 0.11 0.82029 MirTarget -0.17 0.013 NA
103 hsa-let-7g-5p NGF -0.03 0.98708 0.11 0.82029 MirTarget -0.37 5.0E-5 NA
104 hsa-let-7i-5p NGF 0.07 0.97251 0.11 0.82029 MirTarget -0.24 0.01497 NA
105 hsa-miR-320b NGF 0.5 0.81377 0.11 0.82029 miRanda -0.18 0.02089 NA
106 hsa-miR-429 NGF -0.03 0.96574 0.11 0.82029 miRanda -0.22 0.00171 NA
107 hsa-miR-98-5p NGF 0.56 0.50792 0.11 0.82029 MirTarget -0.19 0.00656 NA
108 hsa-miR-130b-3p PIK3CB -0.51 0.60668 0.27 0.8473 miRNATAP -0.08 0.01624 NA
109 hsa-miR-335-3p PIK3CG 0.01 0.99209 -0.05 0.9281 mirMAP -0.16 0.00995 NA
110 hsa-miR-17-5p PIK3R1 -0.69 0.69118 0.35 0.80926 MirTarget; TargetScan; miRNATAP -0.11 0.02188 NA
111 hsa-miR-221-3p PIK3R1 0.08 0.97027 0.35 0.80926 MirTarget -0.21 2.0E-5 NA
112 hsa-miR-222-3p PIK3R1 0.07 0.96964 0.35 0.80926 MirTarget -0.21 1.0E-5 NA
113 hsa-miR-629-3p PIK3R1 -0.56 0.48591 0.35 0.80926 MirTarget -0.18 7.0E-5 NA
114 hsa-miR-28-5p PIK3R2 0.2 0.86472 0.07 0.97312 miRanda -0.1 0.0459 NA
115 hsa-miR-423-5p PIK3R2 -0.35 0.86238 0.07 0.97312 MirTarget -0.12 0.02884 NA
116 hsa-miR-1271-5p PIK3R3 -0.01 0.99155 0.2 0.89177 mirMAP -0.2 0.0004 NA
117 hsa-miR-92a-3p PIK3R3 -0.38 0.92886 0.2 0.89177 MirTarget; miRNATAP -0.3 0.00023 NA
118 hsa-miR-92b-3p PIK3R3 -0.04 0.98973 0.2 0.89177 MirTarget; miRNATAP -0.18 0.00061 NA
119 hsa-miR-106b-5p PPP3CA -0.33 0.77865 0.37 0.78896 miRNATAP -0.09 0.03887 NA
120 hsa-miR-194-5p PPP3CA 0.09 0.94701 0.37 0.78896 MirTarget -0.14 1.0E-5 NA
121 hsa-miR-30a-5p PPP3CA 0.24 0.93548 0.37 0.78896 miRNAWalker2 validate; miRNATAP -0.07 0.04174 NA
122 hsa-miR-30c-5p PPP3CA -0.08 0.9735 0.37 0.78896 miRNATAP -0.12 0.01001 NA
123 hsa-miR-30d-5p PPP3CA 0.08 0.98196 0.37 0.78896 miRNATAP -0.09 0.04738 NA
124 hsa-miR-501-3p PPP3CA 0.31 0.87504 0.37 0.78896 MirTarget; PITA; miRNATAP -0.07 0.02257 NA
125 hsa-miR-616-5p PPP3CA -0.58 0.13268 0.37 0.78896 MirTarget; mirMAP; miRNATAP -0.07 0.03933 NA
126 hsa-miR-93-3p PPP3CA -0.03 0.98385 0.37 0.78896 miRNATAP -0.11 0.0175 NA
127 hsa-miR-93-5p PPP3CA -0.48 0.87936 0.37 0.78896 miRNATAP -0.14 0.00165 NA
128 hsa-miR-15b-5p PPP3CB 0.29 0.91486 0.17 0.90431 miRNATAP -0.1 0.00328 NA
129 hsa-miR-16-5p PPP3CB 0.02 0.98826 0.17 0.90431 miRNATAP -0.1 0.00014 NA
130 hsa-miR-320b PPP3CB 0.5 0.81377 0.17 0.90431 miRanda -0.06 0.00798 NA
131 hsa-miR-330-5p PPP3CB 0.24 0.86638 0.17 0.90431 MirTarget; PITA; miRanda -0.06 0.03816 NA
132 hsa-miR-339-5p PPP3CB -0.13 0.92678 0.17 0.90431 miRanda -0.07 0.01376 NA
133 hsa-miR-361-5p PPP3CB -0.28 0.90427 0.17 0.90431 miRanda -0.11 0.01141 NA
134 hsa-miR-361-5p PPP3CC -0.28 0.90427 0.09 0.9002 miRanda -0.13 0.0292 NA
135 hsa-miR-221-3p PPP3R1 0.08 0.97027 0.27 0.86877 MirTarget; miRNATAP -0.08 0.00022 NA
136 hsa-miR-222-3p PPP3R1 0.07 0.96964 0.27 0.86877 MirTarget; miRNATAP -0.09 2.0E-5 NA
137 hsa-miR-34a-5p PPP3R1 -0.49 0.71188 0.27 0.86877 miRNAWalker2 validate -0.07 0.00154 NA
138 hsa-miR-744-5p PRKACA -0.01 0.99458 0.2 0.91436 miRNAWalker2 validate -0.09 0.03548 NA
139 hsa-miR-141-3p PRKACB -0.14 0.90412 -0.2 0.85892 MirTarget; TargetScan; miRNATAP -0.15 0.00014 NA
140 hsa-miR-182-5p PRKACB -0.14 0.96263 -0.2 0.85892 MirTarget; miRNATAP -0.08 0.00262 NA
141 hsa-miR-183-5p PRKACB -0.04 0.98961 -0.2 0.85892 MirTarget -0.06 0.02996 NA
142 hsa-miR-200a-3p PRKACB -0.25 0.84721 -0.2 0.85892 MirTarget; miRNATAP -0.15 0 NA
143 hsa-miR-200b-3p PRKACB -0.35 0.8855 -0.2 0.85892 MirTarget; TargetScan -0.13 2.0E-5 NA
144 hsa-miR-200c-3p PRKACB -0.62 0.88052 -0.2 0.85892 MirTarget; miRNATAP -0.16 0 NA
145 hsa-miR-30e-3p PRKACB 0.27 0.933 -0.2 0.85892 mirMAP -0.12 0.02604 NA
146 hsa-miR-155-5p PRKAR1A -0.22 0.91433 0.01 0.9974 miRNAWalker2 validate -0.05 0.00815 NA
147 hsa-miR-186-5p PRKAR1A -0.06 0.97402 0.01 0.9974 mirMAP -0.08 0.01573 NA
148 hsa-miR-25-3p PRKAR1A -0.22 0.95112 0.01 0.9974 miRNAWalker2 validate -0.08 0.02511 NA
149 hsa-miR-30c-5p PRKAR1A -0.08 0.9735 0.01 0.9974 mirMAP -0.07 0.03031 NA
150 hsa-miR-324-3p PRKAR1A -0.13 0.94177 0.01 0.9974 miRNAWalker2 validate -0.08 0.01379 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEATH 34 1001 7.014e-29 3.263e-25
2 POSITIVE REGULATION OF RESPONSE TO STIMULUS 41 1929 5.007e-28 1.165e-24
3 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 40 1848 1.897e-27 2.942e-24
4 REGULATION OF CELL DEATH 37 1472 3.428e-27 3.987e-24
5 POSITIVE REGULATION OF MOLECULAR FUNCTION 39 1791 1.127e-26 1.049e-23
6 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 17 99 4.941e-26 3.832e-23
7 INTRACELLULAR SIGNAL TRANSDUCTION 36 1572 6.6e-25 4.387e-22
8 APOPTOTIC SIGNALING PATHWAY 21 289 5.277e-24 3.069e-21
9 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 19 213 2.04e-23 1.055e-20
10 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 34 1492 3.424e-23 1.593e-20
11 RESPONSE TO OXYGEN CONTAINING COMPOUND 33 1381 4.858e-23 2.055e-20
12 POSITIVE REGULATION OF CATALYTIC ACTIVITY 34 1518 5.985e-23 2.321e-20
13 POSITIVE REGULATION OF CELL COMMUNICATION 34 1532 8.051e-23 2.882e-20
14 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 15 95 1.989e-22 6.609e-20
15 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 12 39 6.047e-22 1.876e-19
16 POSITIVE REGULATION OF CELL DEATH 24 605 2.863e-21 7.401e-19
17 NEGATIVE REGULATION OF CELL DEATH 27 872 2.785e-21 7.401e-19
18 ZYMOGEN ACTIVATION 15 112 2.728e-21 7.401e-19
19 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 16 179 9.109e-20 2.231e-17
20 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 15 154 3.906e-19 9.087e-17
21 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 876 9.396e-19 2.082e-16
22 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 13 98 1.759e-18 3.72e-16
23 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 31 1656 2.352e-18 4.555e-16
24 REGULATION OF PEPTIDASE ACTIVITY 19 392 2.27e-18 4.555e-16
25 RESPONSE TO CYTOKINE 23 714 2.448e-18 4.555e-16
26 IMMUNE SYSTEM PROCESS 33 1984 3.606e-18 6.453e-16
27 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 13 5.134e-18 8.847e-16
28 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 16 233 6.511e-18 1.082e-15
29 RESPONSE TO NITROGEN COMPOUND 24 859 9.4e-18 1.508e-15
30 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 14 153 1.644e-17 2.551e-15
31 REGULATION OF PROTEOLYSIS 22 711 3.788e-17 5.686e-15
32 PROTEIN MATURATION 16 265 5.093e-17 7.405e-15
33 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 17 9.608e-17 1.355e-14
34 REGULATION OF KINASE ACTIVITY 22 776 2.362e-16 3.232e-14
35 POSITIVE REGULATION OF PROTEOLYSIS 17 363 3.301e-16 4.267e-14
36 REGULATION OF APOPTOTIC SIGNALING PATHWAY 17 363 3.301e-16 4.267e-14
37 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 9 33 3.831e-16 4.691e-14
38 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 9 33 3.831e-16 4.691e-14
39 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 22 799 4.338e-16 5.175e-14
40 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 14 200 7.322e-16 8.518e-14
41 RESPONSE TO ENDOGENOUS STIMULUS 27 1450 1.138e-15 1.292e-13
42 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 22 1.249e-15 1.384e-13
43 REGULATION OF PHOSPHORUS METABOLIC PROCESS 28 1618 1.714e-15 1.855e-13
44 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 171 2.999e-15 3.171e-13
45 CELLULAR RESPONSE TO NITROGEN COMPOUND 18 505 4.479e-15 4.631e-13
46 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 24 1135 4.95e-15 5.007e-13
47 REGULATION OF IMMUNE SYSTEM PROCESS 26 1403 5.415e-15 5.361e-13
48 NEURON DEATH 9 47 1.311e-14 1.27e-12
49 REGULATION OF TRANSFERASE ACTIVITY 22 946 1.412e-14 1.341e-12
50 REGULATION OF IMMUNE RESPONSE 21 858 2.458e-14 2.287e-12
51 POSITIVE REGULATION OF KINASE ACTIVITY 17 482 3.519e-14 3.211e-12
52 REGULATION OF PROTEIN MODIFICATION PROCESS 27 1710 6.494e-14 5.811e-12
53 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 34 6.899e-14 6.057e-12
54 ACTIVATION OF PROTEIN KINASE ACTIVITY 14 279 7.456e-14 6.425e-12
55 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 22 1036 8.978e-14 7.202e-12
56 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 22 1036 8.978e-14 7.202e-12
57 ACTIVATION OF IMMUNE RESPONSE 16 427 8.934e-14 7.202e-12
58 NEURON APOPTOTIC PROCESS 8 35 8.922e-14 7.202e-12
59 CELLULAR RESPONSE TO CYTOKINE STIMULUS 18 606 1.022e-13 8.059e-12
60 HOMEOSTATIC PROCESS 24 1337 1.809e-13 1.403e-11
61 PHOSPHORYLATION 23 1228 2.862e-13 2.183e-11
62 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 16 470 3.889e-13 2.918e-11
63 POSITIVE REGULATION OF IMMUNE RESPONSE 17 563 4.348e-13 3.211e-11
64 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 14 321 5.065e-13 3.682e-11
65 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 14 323 5.511e-13 3.945e-11
66 RESPONSE TO HORMONE 20 893 6.199e-13 4.37e-11
67 RESPONSE TO ABIOTIC STIMULUS 21 1024 7.604e-13 5.281e-11
68 POSITIVE REGULATION OF HYDROLASE ACTIVITY 20 905 7.928e-13 5.425e-11
69 REGULATION OF HYDROLASE ACTIVITY 23 1327 1.435e-12 9.679e-11
70 PROTEIN PHOSPHORYLATION 20 944 1.721e-12 1.144e-10
71 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 17 616 1.835e-12 1.203e-10
72 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 27 1977 2.11e-12 1.363e-10
73 CYTOKINE MEDIATED SIGNALING PATHWAY 15 452 3.415e-12 2.176e-10
74 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 19 867 3.972e-12 2.495e-10
75 RESPONSE TO TUMOR NECROSIS FACTOR 12 233 4.022e-12 2.495e-10
76 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 55 4.407e-12 2.663e-10
77 EXECUTION PHASE OF APOPTOSIS 8 55 4.407e-12 2.663e-10
78 CHEMICAL HOMEOSTASIS 19 874 4.57e-12 2.726e-10
79 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 20 1008 5.701e-12 3.358e-10
80 RESPONSE TO BIOTIC STIMULUS 19 886 5.795e-12 3.371e-10
81 RESPONSE TO WOUNDING 16 563 5.992e-12 3.442e-10
82 ACTIVATION OF PROTEIN KINASE A ACTIVITY 6 17 6.8e-12 3.859e-10
83 T CELL HOMEOSTASIS 7 34 7.692e-12 4.312e-10
84 RESPONSE TO PEPTIDE 14 404 1.123e-11 6.219e-10
85 REGULATION OF RESPONSE TO STRESS 23 1468 1.142e-11 6.253e-10
86 FC EPSILON RECEPTOR SIGNALING PATHWAY 10 142 1.316e-11 7.122e-10
87 CELLULAR RESPONSE TO ABIOTIC STIMULUS 12 263 1.663e-11 8.895e-10
88 RESPONSE TO EXTERNAL STIMULUS 25 1821 1.82e-11 9.622e-10
89 ACTIVATION OF INNATE IMMUNE RESPONSE 11 204 2.101e-11 1.098e-09
90 CELLULAR RESPONSE TO PEPTIDE 12 274 2.681e-11 1.386e-09
91 POSITIVE REGULATION OF DEFENSE RESPONSE 13 364 4.639e-11 2.372e-09
92 CELLULAR RESPONSE TO HORMONE STIMULUS 15 552 5.761e-11 2.914e-09
93 RESPONSE TO LIPID 18 888 6.025e-11 3.015e-09
94 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 228 6.966e-11 3.448e-09
95 REGULATION OF EXECUTION PHASE OF APOPTOSIS 6 24 7.276e-11 3.564e-09
96 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 7 46 7.442e-11 3.607e-09
97 WOUND HEALING 14 470 8.351e-11 4.006e-09
98 CELLULAR RESPONSE TO MECHANICAL STIMULUS 8 80 9.901e-11 4.701e-09
99 LYMPHOCYTE HOMEOSTASIS 7 50 1.376e-10 6.467e-09
100 PROTEOLYSIS 20 1208 1.472e-10 6.849e-09
101 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 11 246 1.571e-10 7.237e-09
102 TOLL LIKE RECEPTOR SIGNALING PATHWAY 8 85 1.625e-10 7.412e-09
103 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 9 132 2.006e-10 9.064e-09
104 REGULATION OF NEURON DEATH 11 252 2.031e-10 9.088e-09
105 IMMUNE RESPONSE 19 1100 2.375e-10 1.053e-08
106 REGULATION OF CATABOLIC PROCESS 16 731 2.874e-10 1.262e-08
107 RESPONSE TO BACTERIUM 14 528 3.833e-10 1.667e-08
108 FC RECEPTOR SIGNALING PATHWAY 10 206 5.201e-10 2.22e-08
109 LEUKOCYTE HOMEOSTASIS 7 60 5.198e-10 2.22e-08
110 REGULATION OF INNATE IMMUNE RESPONSE 12 357 5.642e-10 2.387e-08
111 T CELL APOPTOTIC PROCESS 5 15 6.014e-10 2.521e-08
112 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 12 360 6.206e-10 2.578e-08
113 RENAL WATER HOMEOSTASIS 6 34 7.104e-10 2.855e-08
114 INFLAMMATORY RESPONSE 13 454 7.015e-10 2.855e-08
115 INTRINSIC APOPTOTIC SIGNALING PATHWAY 9 152 7.08e-10 2.855e-08
116 RENAL SYSTEM PROCESS 8 102 7.118e-10 2.855e-08
117 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 12 370 8.474e-10 3.37e-08
118 RESPONSE TO ORGANIC CYCLIC COMPOUND 17 917 9.096e-10 3.587e-08
119 REGULATION OF CELL PROLIFERATION 21 1496 9.177e-10 3.588e-08
120 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 109 1.213e-09 4.705e-08
121 CELLULAR RESPONSE TO GLUCAGON STIMULUS 6 38 1.445e-09 5.556e-08
122 I KAPPAB KINASE NF KAPPAB SIGNALING 7 70 1.576e-09 6.013e-08
123 LYMPHOCYTE APOPTOTIC PROCESS 5 18 1.704e-09 6.446e-08
124 CELLULAR RESPONSE TO STRESS 21 1565 2.074e-09 7.784e-08
125 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 8 118 2.288e-09 8.517e-08
126 RESPONSE TO TOXIC SUBSTANCE 10 241 2.382e-09 8.796e-08
127 CELLULAR GLUCOSE HOMEOSTASIS 7 75 2.58e-09 9.453e-08
128 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 121 2.795e-09 1.016e-07
129 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 6 43 3.154e-09 1.129e-07
130 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 13 514 3.146e-09 1.129e-07
131 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 129 4.647e-09 1.651e-07
132 NIK NF KAPPAB SIGNALING 7 83 5.298e-09 1.867e-07
133 CELLULAR RESPONSE TO EXTERNAL STIMULUS 10 264 5.717e-09 2e-07
134 RESPONSE TO GLUCAGON 6 48 6.275e-09 2.179e-07
135 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 9 195 6.37e-09 2.196e-07
136 LEUKOCYTE APOPTOTIC PROCESS 5 23 6.616e-09 2.264e-07
137 NEGATIVE REGULATION OF CELL COMMUNICATION 18 1192 6.701e-09 2.276e-07
138 REGULATION OF CELLULAR PROTEIN LOCALIZATION 13 552 7.385e-09 2.49e-07
139 MULTICELLULAR ORGANISMAL HOMEOSTASIS 10 272 7.605e-09 2.546e-07
140 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 19 1360 8.08e-09 2.686e-07
141 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 51 9.146e-09 3.018e-07
142 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 365 9.914e-09 3.249e-07
143 NEGATIVE REGULATION OF MOLECULAR FUNCTION 17 1079 1.049e-08 3.413e-07
144 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 8 144 1.108e-08 3.58e-07
145 RESPONSE TO MECHANICAL STIMULUS 9 210 1.215e-08 3.9e-07
146 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 1.277e-08 4.07e-07
147 RESPONSE TO INORGANIC SUBSTANCE 12 479 1.532e-08 4.848e-07
148 DNA CATABOLIC PROCESS 5 27 1.573e-08 4.945e-07
149 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 6 58 2.022e-08 6.315e-07
150 POSITIVE REGULATION OF PROTEIN IMPORT 7 104 2.581e-08 8.008e-07
151 RESPONSE TO OXYGEN LEVELS 10 311 2.713e-08 8.304e-07
152 HEMOSTASIS 10 311 2.713e-08 8.304e-07
153 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 30 2.757e-08 8.385e-07
154 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 3.557e-08 1.075e-06
155 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 5 32 3.879e-08 1.149e-06
156 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 5 32 3.879e-08 1.149e-06
157 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 5 32 3.879e-08 1.149e-06
158 REGULATION OF DEFENSE RESPONSE 14 759 3.912e-08 1.152e-06
159 GLUCOSE HOMEOSTASIS 8 170 4.058e-08 1.18e-06
160 CARBOHYDRATE HOMEOSTASIS 8 170 4.058e-08 1.18e-06
161 POSITIVE REGULATION OF NEURON DEATH 6 67 4.883e-08 1.411e-06
162 RESPONSE TO METAL ION 10 333 5.159e-08 1.482e-06
163 WATER HOMEOSTASIS 6 70 6.372e-08 1.819e-06
164 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 258 7.167e-08 2.021e-06
165 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 4 14 7.162e-08 2.021e-06
166 DEFENSE RESPONSE 17 1231 7.243e-08 2.03e-06
167 POSITIVE REGULATION OF TRANSPORT 15 936 7.456e-08 2.077e-06
168 CELLULAR HOMEOSTASIS 13 676 8.011e-08 2.219e-06
169 RESPONSE TO OXIDATIVE STRESS 10 352 8.665e-08 2.386e-06
170 AGING 9 264 8.721e-08 2.387e-06
171 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 6 74 8.919e-08 2.427e-06
172 APOPTOTIC DNA FRAGMENTATION 4 15 9.744e-08 2.622e-06
173 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 126 9.748e-08 2.622e-06
174 CELLULAR CHEMICAL HOMEOSTASIS 12 570 1.028e-07 2.75e-06
175 REGULATION OF NEURON APOPTOTIC PROCESS 8 192 1.041e-07 2.767e-06
176 CELL DEVELOPMENT 18 1426 1.054e-07 2.786e-06
177 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 1.164e-07 3.06e-06
178 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 9 282 1.528e-07 3.995e-06
179 POSITIVE REGULATION OF GLUCOSE TRANSPORT 5 42 1.601e-07 4.162e-06
180 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 1.691e-07 4.372e-06
181 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 1004 1.854e-07 4.765e-06
182 REGULATION OF INTRACELLULAR TRANSPORT 12 621 2.588e-07 6.615e-06
183 T CELL RECEPTOR SIGNALING PATHWAY 7 146 2.672e-07 6.794e-06
184 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 218 2.755e-07 6.93e-06
185 DNA CATABOLIC PROCESS ENDONUCLEOLYTIC 4 19 2.742e-07 6.93e-06
186 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 47 2.855e-07 7.141e-06
187 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 220 2.954e-07 7.35e-06
188 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 5 49 3.532e-07 8.742e-06
189 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 5 50 3.916e-07 9.64e-06
190 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 95 3.986e-07 9.761e-06
191 RESPONSE TO ACID CHEMICAL 9 319 4.32e-07 1.052e-05
192 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1087 5.125e-07 1.242e-05
193 REGULATION OF GLUCOSE TRANSPORT 6 100 5.404e-07 1.303e-05
194 RESPONSE TO DRUG 10 431 5.606e-07 1.344e-05
195 REGULATION OF PROTEIN LOCALIZATION 14 950 6.078e-07 1.45e-05
196 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 6.209e-07 1.474e-05
197 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 103 6.437e-07 1.52e-05
198 RESPONSE TO CARBOHYDRATE 7 168 6.915e-07 1.625e-05
199 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 19 1805 7.137e-07 1.669e-05
200 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 106 7.627e-07 1.774e-05
201 NEGATIVE REGULATION OF KINASE ACTIVITY 8 250 7.781e-07 1.801e-05
202 APOPTOTIC NUCLEAR CHANGES 4 25 8.83e-07 2.024e-05
203 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 25 8.83e-07 2.024e-05
204 HOMEOSTASIS OF NUMBER OF CELLS 7 175 9.1e-07 2.055e-05
205 LEUKOCYTE CELL CELL ADHESION 8 255 9.032e-07 2.055e-05
206 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 9.064e-07 2.055e-05
207 RESPONSE TO CORTICOSTEROID 7 176 9.455e-07 2.125e-05
208 REGULATION OF GLUCOSE IMPORT 5 60 9.865e-07 2.207e-05
209 DEVELOPMENTAL PROGRAMMED CELL DEATH 4 26 1.041e-06 2.307e-05
210 REGULATION OF NECROTIC CELL DEATH 4 26 1.041e-06 2.307e-05
211 RESPONSE TO AMINO ACID 6 112 1.055e-06 2.326e-05
212 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 1.116e-06 2.45e-05
213 RESPONSE TO KETONE 7 182 1.184e-06 2.586e-05
214 REGULATION OF PROTEIN IMPORT 7 183 1.228e-06 2.67e-05
215 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 1.42e-06 3.044e-05
216 NECROTIC CELL DEATH 4 28 1.42e-06 3.044e-05
217 REGULATION OF ORGANELLE ORGANIZATION 15 1178 1.411e-06 3.044e-05
218 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 1.514e-06 3.231e-05
219 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 381 1.886e-06 4.006e-05
220 REGULATION OF LIPID METABOLIC PROCESS 8 282 1.918e-06 4.038e-05
221 INOSITOL LIPID MEDIATED SIGNALING 6 124 1.915e-06 4.038e-05
222 RESPONSE TO UV 6 126 2.102e-06 4.406e-05
223 REGULATION OF MEMBRANE PERMEABILITY 5 70 2.137e-06 4.458e-05
224 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 5 71 2.293e-06 4.76e-05
225 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 8 289 2.302e-06 4.76e-05
226 REGULATION OF BODY FLUID LEVELS 10 506 2.383e-06 4.907e-05
227 NEGATIVE REGULATION OF CATABOLIC PROCESS 7 203 2.451e-06 5.024e-05
228 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 4 33 2.806e-06 5.726e-05
229 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1784 2.83e-06 5.751e-05
230 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 9 404 3.046e-06 6.163e-05
231 REGULATION OF TRANSPORT 18 1804 3.317e-06 6.682e-05
232 RESPONSE TO ALKALOID 6 137 3.42e-06 6.859e-05
233 REGULATION OF PROTEIN TARGETING 8 307 3.6e-06 7.189e-05
234 REGULATION OF MAPK CASCADE 11 660 3.658e-06 7.274e-05
235 REGULATION OF CELLULAR LOCALIZATION 15 1277 3.83e-06 7.583e-05
236 REGULATION OF MITOCHONDRION ORGANIZATION 7 218 3.927e-06 7.743e-05
237 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 36 4.012e-06 7.876e-05
238 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 4.148e-06 8.072e-05
239 REGULATION OF NECROPTOTIC PROCESS 3 11 4.163e-06 8.072e-05
240 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 11 4.163e-06 8.072e-05
241 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 10 541 4.316e-06 8.299e-05
242 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 10 541 4.316e-06 8.299e-05
243 NEGATIVE REGULATION OF PHOSPHORYLATION 9 422 4.342e-06 8.315e-05
244 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 4.382e-06 8.357e-05
245 REGULATION OF MAP KINASE ACTIVITY 8 319 4.775e-06 9.068e-05
246 PEPTIDYL SERINE MODIFICATION 6 148 5.343e-06 0.0001011
247 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 1152 5.855e-06 0.0001103
248 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 7 233 6.081e-06 0.0001141
249 CELLULAR RESPONSE TO INTERLEUKIN 1 5 88 6.636e-06 0.000123
250 CELL ACTIVATION 10 568 6.627e-06 0.000123
251 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 88 6.636e-06 0.000123
252 HEPATOCYTE APOPTOTIC PROCESS 3 13 7.186e-06 0.0001316
253 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 3 13 7.186e-06 0.0001316
254 RESPONSE TO COBALT ION 3 13 7.186e-06 0.0001316
255 LYMPHOCYTE ACTIVATION 8 342 7.947e-06 0.000145
256 MITOCHONDRIAL MEMBRANE ORGANIZATION 5 92 8.255e-06 0.0001498
257 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 43 8.274e-06 0.0001498
258 SINGLE ORGANISM CELL ADHESION 9 459 8.551e-06 0.0001542
259 RESPONSE TO VIRUS 7 247 8.902e-06 0.0001599
260 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 44 9.081e-06 0.0001625
261 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 8 351 9.6e-06 0.0001711
262 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 7 252 1.014e-05 0.0001801
263 POSITIVE REGULATION OF MAPK CASCADE 9 470 1.033e-05 0.0001828
264 RESPONSE TO ANTIBIOTIC 4 47 1.185e-05 0.0002089
265 RESPONSE TO ALCOHOL 8 362 1.201e-05 0.0002108
266 NEGATIVE REGULATION OF NEURON DEATH 6 171 1.222e-05 0.0002138
267 REGULATION OF CELL ACTIVATION 9 484 1.306e-05 0.0002267
268 STRIATED MUSCLE CELL DIFFERENTIATION 6 173 1.306e-05 0.0002267
269 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 10 616 1.343e-05 0.0002324
270 RESPONSE TO GAMMA RADIATION 4 50 1.52e-05 0.000262
271 REGULATION OF CELL ADHESION 10 629 1.609e-05 0.0002762
272 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 17 1.694e-05 0.0002887
273 ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY 3 17 1.694e-05 0.0002887
274 REGULATION OF LIPID CATABOLIC PROCESS 4 52 1.779e-05 0.0003021
275 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 53 1.92e-05 0.0003248
276 NEGATIVE REGULATION OF ORGANIC ACID TRANSPORT 3 18 2.028e-05 0.0003407
277 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 2.028e-05 0.0003407
278 PROTEIN DEPHOSPHORYLATION 6 190 2.221e-05 0.0003717
279 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 12 957 2.245e-05 0.0003745
280 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 2.29e-05 0.0003792
281 RESPONSE TO REACTIVE OXYGEN SPECIES 6 191 2.287e-05 0.0003792
282 NEGATIVE REGULATION OF MEIOTIC CELL CYCLE 3 19 2.404e-05 0.0003966
283 RESPONSE TO INTERLEUKIN 1 5 115 2.444e-05 0.0004018
284 APOPTOTIC MITOCHONDRIAL CHANGES 4 57 2.567e-05 0.0004205
285 LEUKOCYTE DIFFERENTIATION 7 292 2.622e-05 0.0004266
286 POSITIVE REGULATION OF CELL PROLIFERATION 11 814 2.621e-05 0.0004266
287 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 5 120 3e-05 0.0004864
288 RESPONSE TO RADIATION 8 413 3.091e-05 0.0004993
289 LEUKOCYTE ACTIVATION 8 414 3.144e-05 0.0005062
290 B CELL HOMEOSTASIS 3 21 3.285e-05 0.0005233
291 NECROPTOTIC PROCESS 3 21 3.285e-05 0.0005233
292 NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS 3 21 3.285e-05 0.0005233
293 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 10 684 3.295e-05 0.0005233
294 REGULATION OF HOMOTYPIC CELL CELL ADHESION 7 307 3.608e-05 0.0005711
295 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 22 3.796e-05 0.0005967
296 LYMPHOCYTE DIFFERENTIATION 6 209 3.792e-05 0.0005967
297 RESPONSE TO ESTROGEN 6 218 4.798e-05 0.0007516
298 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 14 1395 5.01e-05 0.0007823
299 SYSTEM PROCESS 16 1785 5.099e-05 0.0007935
300 IMMUNE SYSTEM DEVELOPMENT 9 582 5.537e-05 0.0008588
301 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 5.633e-05 0.0008707
302 EMBRYO DEVELOPMENT 11 894 6.152e-05 0.0009478
303 NEGATIVE REGULATION OF LIPID TRANSPORT 3 26 6.354e-05 0.0009757
304 MITOCHONDRION ORGANIZATION 9 594 6.478e-05 0.0009916
305 REGULATION OF FATTY ACID TRANSPORT 3 27 7.133e-05 0.001088
306 RESPONSE TO IONIZING RADIATION 5 145 7.407e-05 0.001126
307 RESPONSE TO ESTRADIOL 5 146 7.653e-05 0.001152
308 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 7.653e-05 0.001152
309 MUSCLE CELL DIFFERENTIATION 6 237 7.623e-05 0.001152
310 CELL CELL ADHESION 9 608 7.745e-05 0.001162
311 RESPONSE TO COPPER ION 3 28 7.972e-05 0.001193
312 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 29 8.872e-05 0.001308
313 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 29 8.872e-05 0.001308
314 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 3 29 8.872e-05 0.001308
315 MUSCLE ADAPTATION 3 29 8.872e-05 0.001308
316 INNATE IMMUNE RESPONSE 9 619 8.881e-05 0.001308
317 IMMUNE EFFECTOR PROCESS 8 486 9.688e-05 0.001422
318 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 4 80 9.762e-05 0.001428
319 REGULATION OF AUTOPHAGY 6 249 1e-04 0.001459
320 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 5 156 0.0001046 0.00152
321 REGULATION OF CELL CYCLE 11 949 0.0001049 0.00152
322 REGULATION OF PROTEIN MATURATION 4 82 0.0001075 0.001553
323 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 3 31 0.0001087 0.001566
324 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 6 254 0.0001115 0.001602
325 RESPONSE TO STEROID HORMONE 8 497 0.0001131 0.001619
326 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 8 498 0.0001147 0.001637
327 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 32 0.0001197 0.001703
328 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 7 372 0.0001204 0.001708
329 LEUKOCYTE MIGRATION 6 259 0.0001241 0.001755
330 CELLULAR RESPONSE TO BIOTIC STIMULUS 5 163 0.0001286 0.001813
331 NEGATIVE REGULATION OF ANION TRANSPORT 3 33 0.0001314 0.001846
332 REGULATION OF CELL CELL ADHESION 7 380 0.0001374 0.001925
333 LEUKOCYTE PROLIFERATION 4 88 0.0001414 0.001975
334 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 5 167 0.0001441 0.002001
335 PROTEIN KINASE B SIGNALING 3 34 0.0001438 0.002001
336 RESPONSE TO HEAT 4 89 0.0001477 0.002045
337 CALCIUM MEDIATED SIGNALING 4 90 0.0001542 0.002129
338 CELL PROLIFERATION 9 672 0.0001652 0.002274
339 T CELL PROLIFERATION 3 36 0.0001708 0.002344
340 CELLULAR RESPONSE TO ACID CHEMICAL 5 175 0.0001793 0.002453
341 MITOCHONDRIAL TRANSPORT 5 177 0.000189 0.002578
342 REGULATION OF LIPID TRANSPORT 4 95 0.00019 0.002578
343 RESPONSE TO LIGHT STIMULUS 6 280 0.0001895 0.002578
344 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 9 689 0.0001991 0.002693
345 REGULATION OF CELLULAR RESPONSE TO STRESS 9 691 0.0002034 0.002744
346 DEPHOSPHORYLATION 6 286 0.0002125 0.002858
347 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 3 39 0.0002172 0.002904
348 SPLEEN DEVELOPMENT 3 39 0.0002172 0.002904
349 LIPID PHOSPHORYLATION 4 99 0.0002227 0.002969
350 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 0.0002343 0.003098
351 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0002343 0.003098
352 REGULATION OF ACTIVATED T CELL PROLIFERATION 3 40 0.0002343 0.003098
353 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 8 554 0.0002374 0.00313
354 REGULATION OF CELL CYCLE PROCESS 8 558 0.0002493 0.003276
355 REGULATION OF CYTOKINE PRODUCTION 8 563 0.0002647 0.00347
356 REGULATION OF NIK NF KAPPAB SIGNALING 3 42 0.0002711 0.003544
357 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 9 720 0.0002759 0.003596
358 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 5 193 0.0002822 0.003668
359 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 3 43 0.0002908 0.00377
360 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 8 573 0.000298 0.003852
361 NEGATIVE REGULATION OF CELL CYCLE 7 433 0.000305 0.003931
362 PROTEIN OLIGOMERIZATION 7 434 0.0003092 0.003964
363 ION HOMEOSTASIS 8 576 0.0003086 0.003964
364 RESPONSE TO HYDROGEN PEROXIDE 4 109 0.0003218 0.004114
365 THYMOCYTE AGGREGATION 3 45 0.000333 0.004223
366 POSITIVE REGULATION OF CELL ACTIVATION 6 311 0.0003331 0.004223
367 T CELL DIFFERENTIATION IN THYMUS 3 45 0.000333 0.004223
368 PEPTIDYL THREONINE MODIFICATION 3 46 0.0003555 0.004495
369 OVULATION CYCLE 4 113 0.0003692 0.004655
370 RESPONSE TO INSULIN 5 205 0.0003724 0.004683
371 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 0.0003808 0.004776
372 GAMETE GENERATION 8 595 0.0003834 0.004795
373 POSITIVE REGULATION OF MAP KINASE ACTIVITY 5 207 0.0003893 0.004856
374 REGULATION OF CELL DIFFERENTIATION 13 1492 0.0003964 0.004932
375 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 3 48 0.0004033 0.004978
376 REGULATION OF LIPID KINASE ACTIVITY 3 48 0.0004033 0.004978
377 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 48 0.0004033 0.004978
378 FEMALE SEX DIFFERENTIATION 4 116 0.0004078 0.005007
379 GERM CELL DEVELOPMENT 5 209 0.0004068 0.005007
380 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 8 602 0.0004144 0.005074
381 CELLULAR RESPONSE TO LIPID 7 457 0.0004218 0.005152
382 GLYCEROLIPID BIOSYNTHETIC PROCESS 5 211 0.0004249 0.005176
383 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 118 0.0004351 0.005286
384 MULTICELLULAR ORGANISM REPRODUCTION 9 768 0.0004424 0.005361
385 REGULATION OF ORGANIC ACID TRANSPORT 3 50 0.0004551 0.0055
386 NEGATIVE REGULATION OF NECROTIC CELL DEATH 2 11 0.0004784 0.005767
387 RESPONSE TO NICOTINE 3 51 0.0004825 0.005801
388 REGULATION OF T CELL MEDIATED IMMUNITY 3 52 0.0005109 0.006096
389 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 52 0.0005109 0.006096
390 T CELL DIFFERENTIATION 4 123 0.0005091 0.006096
391 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 11 1142 0.0005194 0.006181
392 RESPONSE TO GROWTH FACTOR 7 475 0.0005311 0.006304
393 REGULATION OF DNA METABOLIC PROCESS 6 340 0.000534 0.006322
394 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 3 53 0.0005404 0.00635
395 NEGATIVE REGULATION OF AUTOPHAGY 3 53 0.0005404 0.00635
396 CELLULAR RESPONSE TO AMINO ACID STIMULUS 3 53 0.0005404 0.00635
397 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.000571 0.00655
398 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 54 0.000571 0.00655
399 REGULATION OF VITAMIN METABOLIC PROCESS 2 12 0.0005729 0.00655
400 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.0005729 0.00655
401 DIVALENT INORGANIC CATION HOMEOSTASIS 6 343 0.0005592 0.00655
402 I KAPPAB PHOSPHORYLATION 2 12 0.0005729 0.00655
403 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 0.000571 0.00655
404 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.0005729 0.00655
405 MYELIN MAINTENANCE 2 12 0.0005729 0.00655
406 POSITIVE REGULATION OF INTERLEUKIN 2 BIOSYNTHETIC PROCESS 2 12 0.0005729 0.00655
407 POSITIVE REGULATION OF EXECUTION PHASE OF APOPTOSIS 2 12 0.0005729 0.00655
408 NEGATIVE REGULATION OF ION TRANSPORT 4 127 0.0005744 0.00655
409 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 10 983 0.0006314 0.007183
410 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 2 13 0.0006758 0.007651
411 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.0006758 0.007651
412 PHOSPHOLIPID BIOSYNTHETIC PROCESS 5 235 0.0006927 0.007824
413 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 135 0.0007225 0.00814
414 CELLULAR RESPONSE TO RADIATION 4 137 0.0007633 0.008559
415 ACTIVATION OF MAPK ACTIVITY 4 137 0.0007633 0.008559
416 REGULATION OF MONOOXYGENASE ACTIVITY 3 60 0.0007778 0.0087
417 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 138 0.0007844 0.008718
418 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 2 14 0.0007869 0.008718
419 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0007869 0.008718
420 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 2 14 0.0007869 0.008718
421 NEUROGENESIS 12 1402 0.0008066 0.008893
422 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 0.0008053 0.008893
423 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 0.0008163 0.008958
424 OVARIAN FOLLICLE DEVELOPMENT 3 61 0.0008163 0.008958
425 POSITIVE REGULATION OF CYTOKINE PRODUCTION 6 370 0.0008305 0.009093
426 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 5 245 0.0008355 0.009125
427 CELLULAR COMPONENT DISASSEMBLY 7 515 0.0008552 0.009319
428 PLATELET ACTIVATION 4 142 0.0008726 0.009487
429 NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION 2 15 0.0009062 0.009784
430 POSITIVE REGULATION OF NUCLEASE ACTIVITY 2 15 0.0009062 0.009784
431 NEUROTROPHIN TRK RECEPTOR SIGNALING PATHWAY 2 15 0.0009062 0.009784
NumGOOverlapSizeP ValueAdj. P Value
1 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 6 15 2.763e-12 2.567e-09
2 ENZYME BINDING 25 1737 6.465e-12 3.003e-09
3 CYTOKINE RECEPTOR BINDING 12 271 2.359e-11 7.304e-09
4 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 7 47 8.725e-11 2.026e-08
5 KINASE ACTIVITY 17 842 2.465e-10 4.579e-08
6 PROTEIN HETERODIMERIZATION ACTIVITY 13 468 1.015e-09 1.571e-07
7 DEATH RECEPTOR BINDING 5 18 1.704e-09 2.262e-07
8 KINASE BINDING 14 606 2.273e-09 2.64e-07
9 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 17 992 2.988e-09 3.084e-07
10 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 7 86 6.808e-09 5.75e-07
11 PROTEIN SERINE THREONINE KINASE ACTIVITY 12 445 6.762e-09 5.75e-07
12 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 5 30 2.757e-08 2.135e-06
13 PROTEIN KINASE ACTIVITY 13 640 4.235e-08 3.026e-06
14 KINASE REGULATOR ACTIVITY 8 186 8.148e-08 5.406e-06
15 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 4 15 9.744e-08 5.941e-06
16 ENZYME REGULATOR ACTIVITY 15 959 1.023e-07 5.941e-06
17 INTERLEUKIN 1 RECEPTOR BINDING 4 16 1.296e-07 7.084e-06
18 PROTEIN KINASE A BINDING 5 42 1.601e-07 8.264e-06
19 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 5 43 1.808e-07 8.839e-06
20 ADENYL NUCLEOTIDE BINDING 18 1514 2.586e-07 1.201e-05
21 MOLECULAR FUNCTION REGULATOR 17 1353 2.808e-07 1.242e-05
22 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 5 51 4.331e-07 1.829e-05
23 CAMP BINDING 4 23 6.209e-07 2.508e-05
24 PROTEASE BINDING 6 104 6.815e-07 2.638e-05
25 DEATH RECEPTOR ACTIVITY 4 24 7.434e-07 2.762e-05
26 PROTEIN DIMERIZATION ACTIVITY 15 1149 1.033e-06 3.69e-05
27 UBIQUITIN LIKE PROTEIN LIGASE BINDING 8 264 1.172e-06 4.032e-05
28 CYSTEINE TYPE PEPTIDASE ACTIVITY 7 184 1.274e-06 4.225e-05
29 IDENTICAL PROTEIN BINDING 15 1209 1.95e-06 6.039e-05
30 TUMOR NECROSIS FACTOR RECEPTOR BINDING 4 30 1.892e-06 6.039e-05
31 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 5 70 2.137e-06 6.203e-05
32 PROTEIN DOMAIN SPECIFIC BINDING 11 624 2.133e-06 6.203e-05
33 CYCLIC NUCLEOTIDE BINDING 4 36 4.012e-06 0.0001129
34 RIBONUCLEOTIDE BINDING 18 1860 5.112e-06 0.0001397
35 KINASE INHIBITOR ACTIVITY 5 89 7.015e-06 0.0001862
36 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 4 42 7.521e-06 0.0001941
37 ENZYME INHIBITOR ACTIVITY 8 378 1.641e-05 0.0004119
38 RECEPTOR BINDING 15 1476 2.184e-05 0.0005339
39 PROTEIN PHOSPHATASE BINDING 5 120 3e-05 0.0007147
40 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 4.064e-05 0.0009439
41 PHOSPHATASE BINDING 5 162 0.0001249 0.002831
42 HEAT SHOCK PROTEIN BINDING 4 89 0.0001477 0.003267
43 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 178 0.000194 0.004192
44 PROTEIN HOMODIMERIZATION ACTIVITY 9 722 0.0002816 0.005945
45 HYDROLASE ACTIVITY ACTING ON ESTER BONDS 9 739 0.0003341 0.006898
46 ENDOPEPTIDASE ACTIVITY 7 448 0.0003744 0.007562
47 PEPTIDASE REGULATOR ACTIVITY 5 214 0.0004532 0.008958
48 SIGNAL TRANSDUCER ACTIVITY 14 1731 0.0004855 0.009205
49 INSULIN RECEPTOR SUBSTRATE BINDING 2 11 0.0004784 0.009205
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 14 237 7.836e-15 4.576e-12
2 CATALYTIC COMPLEX 21 1038 9.869e-13 2.882e-10
3 MEMBRANE MICRODOMAIN 13 288 2.466e-12 4.8e-10
4 PROTEIN KINASE COMPLEX 9 90 6.153e-12 8.983e-10
5 CILIARY BASE 6 23 5.47e-11 6.389e-09
6 MEMBRANE PROTEIN COMPLEX 18 1020 5.68e-10 5.528e-08
7 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 5 20 3.069e-09 2.561e-07
8 TRANSFERASE COMPLEX 14 703 1.499e-08 1.094e-06
9 CYTOSOLIC PART 8 223 3.275e-07 2.125e-05
10 PLASMA MEMBRANE PROTEIN COMPLEX 10 510 2.557e-06 0.0001493
11 IKAPPAB KINASE COMPLEX 3 11 4.163e-06 0.000221
12 MEMBRANE REGION 14 1134 4.883e-06 0.0002376
13 PHOSPHATASE COMPLEX 4 48 1.29e-05 0.0005795
14 CILIARY PART 7 307 3.608e-05 0.001505
15 MITOCHONDRION 15 1633 7.049e-05 0.002745
16 PERINUCLEAR REGION OF CYTOPLASM 9 642 0.0001171 0.004276
17 PLASMA MEMBRANE RAFT 4 86 0.0001293 0.004443

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 60 89 1.769e-153 3.132e-151
2 hsa04662_B_cell_receptor_signaling_pathway 17 75 2.79e-28 2.469e-26
3 hsa04660_T_cell_receptor_signaling_pathway 18 108 2.649e-27 1.563e-25
4 hsa04380_Osteoclast_differentiation 18 128 6.93e-26 3.067e-24
5 hsa04010_MAPK_signaling_pathway 21 268 1.061e-24 3.754e-23
6 hsa04722_Neurotrophin_signaling_pathway 17 127 4.509e-24 1.33e-22
7 hsa04620_Toll.like_receptor_signaling_pathway 16 102 7.622e-24 1.927e-22
8 hsa04650_Natural_killer_cell_mediated_cytotoxicity 17 136 1.532e-23 3.389e-22
9 hsa04370_VEGF_signaling_pathway 14 76 5.576e-22 1.097e-20
10 hsa04910_Insulin_signaling_pathway 15 138 7.163e-20 1.268e-18
11 hsa04062_Chemokine_signaling_pathway 14 189 3.304e-16 5.316e-15
12 hsa04914_Progesterone.mediated_oocyte_maturation 10 87 8.989e-14 1.326e-12
13 hsa04973_Carbohydrate_digestion_and_absorption 8 44 6.58e-13 8.343e-12
14 hsa04510_Focal_adhesion 12 200 6.599e-13 8.343e-12
15 hsa04150_mTOR_signaling_pathway 8 52 2.743e-12 3.236e-11
16 hsa04920_Adipocytokine_signaling_pathway 8 68 2.596e-11 2.872e-10
17 hsa04630_Jak.STAT_signaling_pathway 10 155 3.155e-11 3.285e-10
18 hsa04664_Fc_epsilon_RI_signaling_pathway 8 79 8.932e-11 8.783e-10
19 hsa04012_ErbB_signaling_pathway 8 87 1.964e-10 1.829e-09
20 hsa04666_Fc_gamma_R.mediated_phagocytosis 8 95 4.01e-10 3.549e-09
21 hsa04621_NOD.like_receptor_signaling_pathway 7 59 4.602e-10 3.879e-09
22 hsa04115_p53_signaling_pathway 7 69 1.422e-09 1.144e-08
23 hsa04720_Long.term_potentiation 7 70 1.576e-09 1.213e-08
24 hsa04622_RIG.I.like_receptor_signaling_pathway 7 71 1.745e-09 1.287e-08
25 hsa04114_Oocyte_meiosis 7 114 4.885e-08 3.459e-07
26 hsa04960_Aldosterone.regulated_sodium_reabsorption 5 42 1.601e-07 1.09e-06
27 hsa04310_Wnt_signaling_pathway 7 151 3.36e-07 2.203e-06
28 hsa04623_Cytosolic_DNA.sensing_pathway 5 56 6.963e-07 4.402e-06
29 hsa04020_Calcium_signaling_pathway 7 177 9.821e-07 5.994e-06
30 hsa04070_Phosphatidylinositol_signaling_system 5 78 3.659e-06 2.159e-05
31 hsa04670_Leukocyte_transendothelial_migration 5 117 2.656e-05 0.0001517
32 hsa04360_Axon_guidance 5 130 4.405e-05 0.0002436
33 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.0004532 0.002431
34 hsa04530_Tight_junction 3 133 0.007464 0.03886
35 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.007722 0.03905
36 hsa04742_Taste_transduction 2 52 0.01066 0.0524
37 hsa04340_Hedgehog_signaling_pathway 2 56 0.01228 0.05876
38 hsa00562_Inositol_phosphate_metabolism 2 57 0.01271 0.05919
39 hsa04141_Protein_processing_in_endoplasmic_reticulum 3 168 0.01404 0.06372
40 hsa04976_Bile_secretion 2 71 0.01926 0.08523
41 hsa04971_Gastric_acid_secretion 2 74 0.02082 0.08987
42 hsa04640_Hematopoietic_cell_lineage 2 88 0.02873 0.1204
43 hsa04970_Salivary_secretion 2 89 0.02933 0.1204
44 hsa04540_Gap_junction 2 90 0.02994 0.1204
45 hsa04912_GnRH_signaling_pathway 2 101 0.03697 0.1423
46 hsa04916_Melanogenesis 2 101 0.03697 0.1423
47 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.04747 0.1788
48 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.06536 0.241
49 hsa04740_Olfactory_transduction 2 388 0.325 1

Quest ID: c000215dbc579adaf498e36dbd79c262