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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-181d-5p ACSL1 0.15 0.888 -0.05 0.97145 MirTarget -0.15 0.00429 NA
2 hsa-miR-191-5p ACSL1 -0.48 0.81535 -0.05 0.97145 miRNAWalker2 validate -0.22 0.00167 NA
3 hsa-miR-192-5p ACSL1 -0.12 0.97293 -0.05 0.97145 miRNAWalker2 validate -0.17 0.00124 NA
4 hsa-miR-335-5p ACSL1 -0.03 0.97338 -0.05 0.97145 miRNAWalker2 validate -0.25 3.0E-5 NA
5 hsa-miR-454-3p ACSL1 -0.1 0.84355 -0.05 0.97145 MirTarget -0.37 0 NA
6 hsa-miR-26b-3p ACSL4 -0.36 0.68112 0.11 0.93597 MirTarget -0.18 0.00094 NA
7 hsa-miR-26b-5p ACSL4 -0.02 0.99038 0.11 0.93597 mirMAP -0.25 0.00043 NA
8 hsa-miR-429 ACSL4 -0.46 0.80624 0.11 0.93597 miRanda; miRNATAP -0.14 0.00089 NA
9 hsa-miR-495-3p ACSL4 0 0.99753 0.11 0.93597 mirMAP -0.19 0.00434 NA
10 hsa-miR-590-3p ACSL4 -0.28 0.59127 0.11 0.93597 MirTarget; PITA; miRanda; mirMAP -0.12 0.00663 NA
11 hsa-miR-7-1-3p ACSL4 -0.46 0.6659 0.11 0.93597 mirMAP -0.14 0.00889 NA
12 hsa-let-7b-5p ACSL6 -0.23 0.93895 0.56 0.53055 miRNATAP -0.95 0.00213 NA
13 hsa-miR-150-3p ACSL6 -0.29 0.51427 0.56 0.53055 MirTarget; miRNATAP -0.44 0.00158 NA
14 hsa-miR-155-5p ACSL6 -0.41 0.82867 0.56 0.53055 mirMAP -0.95 1.0E-5 NA
15 hsa-miR-27b-5p ACSL6 -0.33 0.68662 0.56 0.53055 MirTarget -1.52 0 NA
16 hsa-miR-582-5p ACSL6 -0.4 0.58123 0.56 0.53055 mirMAP; miRNATAP -0.82 0.00055 NA
17 hsa-miR-21-3p ADIPOQ -0.4 0.8782 -0.07 0.95604 MirTarget -1.45 0 NA
18 hsa-miR-30b-3p ADIPOQ -0.51 0.16242 -0.07 0.95604 MirTarget -0.69 0.00662 NA
19 hsa-miR-339-5p ADIPOQ -0.3 0.71291 -0.07 0.95604 miRanda -0.65 0.0023 NA
20 hsa-miR-429 ADIPOQ -0.46 0.80624 -0.07 0.95604 miRanda -1.39 0 NA
21 hsa-miR-491-3p ADIPOQ -0.51 0.13784 -0.07 0.95604 MirTarget -0.7 0.00142 NA
22 hsa-miR-501-3p ADIPOQ -0.75 0.55276 -0.07 0.95604 MirTarget -0.96 7.0E-5 NA
23 hsa-miR-502-3p ADIPOQ -0.48 0.5143 -0.07 0.95604 MirTarget -1.04 0.00022 NA
24 hsa-miR-577 ADIPOQ -1.06 0.32606 -0.07 0.95604 mirMAP -0.8 0 NA
25 hsa-miR-590-3p ADIPOQ -0.28 0.59127 -0.07 0.95604 PITA; miRanda; mirMAP -1.02 0 NA
26 hsa-miR-940 ADIPOQ -0.23 0.68006 -0.07 0.95604 MirTarget -0.75 5.0E-5 NA
27 hsa-miR-26b-5p CD36 -0.02 0.99038 0.68 0.31744 miRNAWalker2 validate -0.66 8.0E-5 NA
28 hsa-miR-335-5p CD36 -0.03 0.97338 0.68 0.31744 miRNAWalker2 validate -0.51 1.0E-5 NA
29 hsa-miR-362-3p CD36 -0.72 0.03459 0.68 0.31744 miRanda -0.36 0.00049 NA
30 hsa-miR-421 CD36 -0.18 0.7347 0.68 0.31744 miRanda -0.37 0.00244 NA
31 hsa-miR-590-3p CD36 -0.28 0.59127 0.68 0.31744 miRanda -0.52 0 NA
32 hsa-miR-629-3p CD36 -0.5 0.33397 0.68 0.31744 MirTarget -0.35 0.00045 NA
33 hsa-miR-96-5p CD36 0.09 0.92309 0.68 0.31744 MirTarget -0.67 0 NA
34 hsa-miR-491-5p CPT1C -0.59 0.04526 0.64 0.07216 miRanda -0.22 0.00449 NA
35 hsa-miR-188-3p FABP4 -0.29 0.47502 1.24 0.11904 MirTarget -0.75 0 NA
36 hsa-miR-30c-1-3p FABP4 -0.2 0.51149 1.24 0.11904 MirTarget -0.93 0 NA
37 hsa-miR-335-5p FABP4 -0.03 0.97338 1.24 0.11904 miRNAWalker2 validate -0.87 0 NA
38 hsa-miR-361-5p FABP4 -0.14 0.9415 1.24 0.11904 MirTarget; miRanda -1.48 2.0E-5 NA
39 hsa-miR-455-3p FABP4 -0.36 0.82464 1.24 0.11904 miRNATAP -0.97 0 NA
40 hsa-miR-589-3p FABP4 -0.84 0.0112 1.24 0.11904 MirTarget -0.82 0 NA
41 hsa-miR-590-3p FABP4 -0.28 0.59127 1.24 0.11904 miRanda -1.03 0 NA
42 hsa-miR-26b-5p FADS2 -0.02 0.99038 0.51 0.6691 miRNAWalker2 validate -0.59 7.0E-5 NA
43 hsa-miR-335-5p FADS2 -0.03 0.97338 0.51 0.6691 miRNAWalker2 validate -0.59 0 NA
44 hsa-miR-361-5p FADS2 -0.14 0.9415 0.51 0.6691 miRanda -0.96 0 NA
45 hsa-miR-423-3p FADS2 -0.35 0.81316 0.51 0.6691 miRNAWalker2 validate -0.51 7.0E-5 NA
46 hsa-miR-500a-3p FADS2 -0.63 0.73258 0.51 0.6691 miRNAWalker2 validate -0.59 0 NA
47 hsa-miR-185-3p ILK 0.1 0.85691 0.13 0.93511 MirTarget; miRNATAP -0.15 0 NA
48 hsa-miR-222-3p ILK -0.03 0.98401 0.13 0.93511 miRNAWalker2 validate -0.1 0.00065 NA
49 hsa-miR-30c-1-3p ILK -0.2 0.51149 0.13 0.93511 MirTarget -0.12 0 NA
50 hsa-miR-335-3p ILK -0.24 0.8845 0.13 0.93511 MirTarget -0.16 0 NA
51 hsa-miR-361-3p ILK -0.29 0.84773 0.13 0.93511 miRNATAP -0.2 0 NA
52 hsa-miR-148b-3p LPL -0.2 0.91188 0.84 0.30981 miRNAWalker2 validate -0.53 0.00381 NA
53 hsa-miR-29b-3p LPL -0.1 0.95899 0.84 0.30981 miRNATAP -0.39 0.00181 NA
54 hsa-miR-590-3p LPL -0.28 0.59127 0.84 0.30981 miRanda; mirMAP; miRNATAP -0.39 0.00019 NA
55 hsa-miR-361-5p MMP1 -0.14 0.9415 -0.33 0.81332 miRanda -0.99 0.00042 NA
56 hsa-miR-320a OLR1 -0.42 0.8402 0.49 0.44526 miRanda -0.7 2.0E-5 NA
57 hsa-miR-320b OLR1 -0.24 0.85922 0.49 0.44526 miRanda -0.51 0.00052 NA
58 hsa-miR-320c OLR1 -0.58 0.1136 0.49 0.44526 miRanda -0.32 0.0032 NA
59 hsa-miR-335-3p OLR1 -0.24 0.8845 0.49 0.44526 mirMAP -0.69 0 NA
60 hsa-miR-421 OLR1 -0.18 0.7347 0.49 0.44526 miRanda -0.51 0.0001 NA
61 hsa-miR-491-3p OLR1 -0.51 0.13784 0.49 0.44526 MirTarget -0.49 2.0E-5 NA
62 hsa-miR-501-3p OLR1 -0.75 0.55276 0.49 0.44526 TargetScan -0.44 0.00065 NA
63 hsa-miR-590-3p OLR1 -0.28 0.59127 0.49 0.44526 miRanda; mirMAP -0.63 0 NA
64 hsa-miR-590-5p OLR1 -0.55 0.47274 0.49 0.44526 miRanda -0.78 0 NA
65 hsa-miR-96-5p OLR1 0.09 0.92309 0.49 0.44526 MirTarget -0.7 0 NA
66 hsa-miR-22-5p PDPK1 -0.08 0.9317 -0 0.99893 miRNATAP -0.11 0.00108 NA
67 hsa-miR-942-5p PLTP -0.51 0.50778 -0.1 0.9433 MirTarget -0.2 0.00917 NA
68 hsa-let-7i-5p PPARA -0.2 0.92202 -0.15 0.91191 miRNATAP -0.35 0 NA
69 hsa-miR-146b-5p PPARA -0.4 0.83751 -0.15 0.91191 mirMAP -0.16 0.00109 NA
70 hsa-miR-193b-5p PPARA 0.2 0.60647 -0.15 0.91191 mirMAP -0.1 0.00932 NA
71 hsa-miR-218-5p PPARA 0.23 0.81021 -0.15 0.91191 mirMAP -0.11 0.00341 NA
72 hsa-miR-369-3p PPARA 0.12 0.8323 -0.15 0.91191 mirMAP -0.11 0.00834 NA
73 hsa-miR-382-5p PPARA 0.04 0.96032 -0.15 0.91191 mirMAP -0.16 0.00169 NA
74 hsa-miR-455-5p PPARA -0.14 0.86574 -0.15 0.91191 miRanda -0.11 0.00991 NA
75 hsa-miR-92a-3p PPARD 0.03 0.99325 0.1 0.93929 miRNAWalker2 validate -0.15 0.00019 NA
76 hsa-miR-511-5p PPARG -0.31 0.6072 0.06 0.96454 MirTarget -0.21 0.00019 NA
77 hsa-miR-30c-2-3p RXRB 0.24 0.74693 0.04 0.9769 MirTarget -0.14 0 NA
78 hsa-let-7g-3p RXRG -0.49 0.62942 0.29 0.79217 MirTarget; miRNATAP -0.46 0 NA
79 hsa-miR-23a-3p RXRG -0.12 0.96272 0.29 0.79217 MirTarget -0.69 0.00085 NA
80 hsa-miR-362-3p RXRG -0.72 0.03459 0.29 0.79217 miRNATAP -0.24 0.00785 NA
81 hsa-miR-141-3p SCD5 -0.32 0.87774 -0.32 0.67415 TargetScan -0.3 0.00019 NA
82 hsa-miR-17-5p SCD5 -0.18 0.93454 -0.32 0.67415 TargetScan -0.25 0.00271 NA
83 hsa-miR-30b-5p SCD5 -0.01 0.99462 -0.32 0.67415 mirMAP -0.3 0.00167 NA
84 hsa-miR-339-5p SCD5 -0.3 0.71291 -0.32 0.67415 miRanda -0.29 0.00024 NA
85 hsa-miR-362-3p SCD5 -0.72 0.03459 -0.32 0.67415 miRanda -0.2 0.00924 NA
86 hsa-miR-374a-5p SCD5 -0.34 0.76692 -0.32 0.67415 MirTarget; mirMAP -0.54 7.0E-5 NA
87 hsa-miR-374b-5p SCD5 -0.29 0.8357 -0.32 0.67415 MirTarget; mirMAP -0.56 3.0E-5 NA
88 hsa-miR-590-5p SCD5 -0.55 0.47274 -0.32 0.67415 miRanda -0.43 0 NA
89 hsa-miR-592 SCD5 -0.18 0.85623 -0.32 0.67415 MirTarget -0.15 0.00012 NA
90 hsa-miR-34c-5p SCP2 -0.02 0.95279 -0.19 0.90676 miRanda -0.12 0.0003 NA
91 hsa-miR-18a-5p SLC27A1 -0.5 0.61264 -0.01 0.99455 mirMAP -0.18 5.0E-5 NA
92 hsa-miR-194-3p SLC27A1 -0.61 0.73321 -0.01 0.99455 MirTarget; mirMAP -0.31 0 NA
93 hsa-miR-421 SLC27A1 -0.18 0.7347 -0.01 0.99455 miRanda; mirMAP -0.28 0 NA
94 hsa-miR-940 SLC27A1 -0.23 0.68006 -0.01 0.99455 MirTarget -0.18 4.0E-5 NA
95 hsa-let-7a-3p SORBS1 -0.22 0.85543 0.41 0.75061 miRNATAP -0.55 0 NA
96 hsa-let-7b-3p SORBS1 -0.29 0.81216 0.41 0.75061 miRNATAP -0.49 8.0E-5 NA
97 hsa-let-7g-3p SORBS1 -0.49 0.62942 0.41 0.75061 miRNATAP -0.44 0 NA
98 hsa-miR-142-5p SORBS1 -0.12 0.92967 0.41 0.75061 PITA; miRNATAP -0.38 0 NA
99 hsa-miR-146b-5p SORBS1 -0.4 0.83751 0.41 0.75061 miRanda -0.38 0.0002 NA
100 hsa-miR-186-5p SORBS1 -0.32 0.85413 0.41 0.75061 mirMAP -0.8 0 NA
101 hsa-miR-19b-1-5p SORBS1 -0.01 0.98851 0.41 0.75061 mirMAP -0.43 0 NA
102 hsa-miR-22-5p SORBS1 -0.08 0.9317 0.41 0.75061 mirMAP -0.36 2.0E-5 NA
103 hsa-miR-320a SORBS1 -0.42 0.8402 0.41 0.75061 miRNAWalker2 validate; mirMAP -0.4 0.00015 NA
104 hsa-miR-320b SORBS1 -0.24 0.85922 0.41 0.75061 mirMAP -0.32 0.0008 NA
105 hsa-miR-339-5p SORBS1 -0.3 0.71291 0.41 0.75061 miRanda -0.39 0 NA
106 hsa-miR-345-5p SORBS1 -0.72 0.40504 0.41 0.75061 miRNATAP -0.39 0 NA
107 hsa-miR-429 SORBS1 -0.46 0.80624 0.41 0.75061 miRNATAP -0.48 0 NA
108 hsa-miR-539-5p SORBS1 0.12 0.80107 0.41 0.75061 mirMAP -0.35 0.00041 NA
109 hsa-miR-577 SORBS1 -1.06 0.32606 0.41 0.75061 miRNATAP -0.33 0 NA
110 hsa-miR-582-5p SORBS1 -0.4 0.58123 0.41 0.75061 miRNATAP -0.59 0 NA
111 hsa-miR-584-5p SORBS1 -0.22 0.90686 0.41 0.75061 mirMAP -0.29 0 NA
112 hsa-miR-590-3p SORBS1 -0.28 0.59127 0.41 0.75061 miRanda -0.55 0 NA
113 hsa-miR-590-5p SORBS1 -0.55 0.47274 0.41 0.75061 miRanda -0.55 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 FATTY ACID METABOLIC PROCESS 13 296 1.259e-18 5.858e-15
2 MONOCARBOXYLIC ACID METABOLIC PROCESS 13 503 1.257e-15 2.924e-12
3 LIPID METABOLIC PROCESS 16 1158 2.408e-15 3.735e-12
4 CELLULAR LIPID METABOLIC PROCESS 14 913 8.619e-14 1.003e-10
5 FATTY ACID TRANSPORT 7 56 2.165e-13 2.015e-10
6 ORGANIC ACID METABOLIC PROCESS 13 953 4.421e-12 3.428e-09
7 HORMONE MEDIATED SIGNALING PATHWAY 8 158 5.627e-12 3.741e-09
8 LIPID LOCALIZATION 9 264 7.383e-12 4.294e-09
9 MONOCARBOXYLIC ACID TRANSPORT 7 124 6.701e-11 3.464e-08
10 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 5 28 1.22e-10 5.674e-08
11 CELLULAR RESPONSE TO HORMONE STIMULUS 10 552 1.96e-10 8.289e-08
12 LONG CHAIN FATTY ACID METABOLIC PROCESS 6 88 5.801e-10 2.249e-07
13 SMALL MOLECULE METABOLIC PROCESS 14 1767 6.389e-10 2.287e-07
14 REGULATION OF LIPID TRANSPORT 6 95 9.256e-10 2.927e-07
15 REGULATION OF CHOLESTEROL STORAGE 4 13 9.435e-10 2.927e-07
16 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 11 1008 3.905e-09 1.136e-06
17 ORGANIC ANION TRANSPORT 8 387 6.955e-09 1.904e-06
18 ORGANIC ACID TRANSPORT 7 261 1.22e-08 3.154e-06
19 CELLULAR LIPID CATABOLIC PROCESS 6 151 1.522e-08 3.541e-06
20 LIPID OXIDATION 5 70 1.455e-08 3.541e-06
21 RESPONSE TO HORMONE 10 893 2.017e-08 4.469e-06
22 ANION TRANSPORT 8 507 5.661e-08 1.197e-05
23 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 36 7.638e-08 1.545e-05
24 RESPONSE TO INSULIN 6 205 9.408e-08 1.647e-05
25 REGULATION OF STEROL TRANSPORT 4 38 9.557e-08 1.647e-05
26 LIPID BIOSYNTHETIC PROCESS 8 539 9.068e-08 1.647e-05
27 REGULATION OF CHOLESTEROL TRANSPORT 4 38 9.557e-08 1.647e-05
28 RESPONSE TO OXYGEN CONTAINING COMPOUND 11 1381 1.019e-07 1.694e-05
29 REGULATION OF LIPID STORAGE 4 41 1.308e-07 2.099e-05
30 LONG CHAIN FATTY ACID TRANSPORT 4 42 1.445e-07 2.241e-05
31 RESPONSE TO ENDOGENOUS STIMULUS 11 1450 1.677e-07 2.517e-05
32 REGULATION OF PLASMA LIPOPROTEIN PARTICLE LEVELS 4 45 1.919e-07 2.79e-05
33 REGULATION OF SEQUESTERING OF TRIGLYCERIDE 3 12 2.903e-07 3.752e-05
34 REGULATION OF RESPONSE TO WOUNDING 7 413 2.804e-07 3.752e-05
35 STEROID HORMONE MEDIATED SIGNALING PATHWAY 5 125 2.706e-07 3.752e-05
36 LIPID CATABOLIC PROCESS 6 247 2.827e-07 3.752e-05
37 FATTY ACID BETA OXIDATION 4 51 3.204e-07 3.822e-05
38 FATTY ACYL COA METABOLIC PROCESS 4 51 3.204e-07 3.822e-05
39 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 5 128 3.045e-07 3.822e-05
40 ALPHA LINOLENIC ACID METABOLIC PROCESS 3 13 3.771e-07 4.28e-05
41 NEGATIVE REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 3 13 3.771e-07 4.28e-05
42 ACYL COA BIOSYNTHETIC PROCESS 4 54 4.045e-07 4.377e-05
43 THIOESTER BIOSYNTHETIC PROCESS 4 54 4.045e-07 4.377e-05
44 POSITIVE REGULATION OF TRANSPORT 9 936 4.678e-07 4.947e-05
45 REGULATION OF LIPID METABOLIC PROCESS 6 282 6.148e-07 6.357e-05
46 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 3 16 7.367e-07 7.314e-05
47 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 5 153 7.388e-07 7.314e-05
48 REGULATION OF INFLAMMATORY RESPONSE 6 294 7.843e-07 7.603e-05
49 POSITIVE REGULATION OF STEROL TRANSPORT 3 17 8.939e-07 8.319e-05
50 POSITIVE REGULATION OF CHOLESTEROL TRANSPORT 3 17 8.939e-07 8.319e-05
51 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 5 168 1.173e-06 0.000107
52 REGULATION OF DEFENSE RESPONSE 8 759 1.225e-06 0.0001096
53 FATTY ACID CATABOLIC PROCESS 4 73 1.372e-06 0.0001205
54 REGULATION OF TRANSPORT 11 1804 1.516e-06 0.0001306
55 REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 3 21 1.743e-06 0.0001475
56 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 11 1848 1.926e-06 0.00016
57 THIOESTER METABOLIC PROCESS 4 83 2.299e-06 0.0001783
58 RESPONSE TO FATTY ACID 4 83 2.299e-06 0.0001783
59 ACYL COA METABOLIC PROCESS 4 83 2.299e-06 0.0001783
60 RESPONSE TO NUTRIENT 5 191 2.206e-06 0.0001783
61 NEUTRAL LIPID METABOLIC PROCESS 4 85 2.529e-06 0.0001929
62 DNA TEMPLATED TRANSCRIPTION INITIATION 5 202 2.903e-06 0.0002178
63 LIPID MODIFICATION 5 210 3.51e-06 0.0002593
64 RESPONSE TO LIPID 8 888 3.956e-06 0.0002876
65 MONOCARBOXYLIC ACID CATABOLIC PROCESS 4 96 4.115e-06 0.0002946
66 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 5 218 4.214e-06 0.0002971
67 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 4 100 4.843e-06 0.0003314
68 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 4.843e-06 0.0003314
69 RESPONSE TO PEPTIDE 6 404 4.939e-06 0.000333
70 RESPONSE TO ORGANIC CYCLIC COMPOUND 8 917 5.02e-06 0.0003337
71 UNSATURATED FATTY ACID METABOLIC PROCESS 4 109 6.824e-06 0.0004472
72 POSITIVE REGULATION OF FATTY ACID METABOLIC PROCESS 3 33 7.087e-06 0.000458
73 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 8.156e-06 0.0005198
74 SMALL MOLECULE BIOSYNTHETIC PROCESS 6 443 8.369e-06 0.0005262
75 SINGLE ORGANISM BIOSYNTHETIC PROCESS 9 1340 9.161e-06 0.0005684
76 CELLULAR RESPONSE TO LIPID 6 457 9.993e-06 0.0006118
77 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 1.103e-05 0.0006666
78 COENZYME BIOSYNTHETIC PROCESS 4 127 1.25e-05 0.0007459
79 RESPONSE TO COLD 3 43 1.591e-05 0.0009361
80 RESPONSE TO STEROID HORMONE 6 497 1.609e-05 0.0009361
81 NEGATIVE REGULATION OF DEFENSE RESPONSE 4 144 2.052e-05 0.001179
82 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 2.166e-05 0.001229
83 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 3 49 2.365e-05 0.001326
84 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 6 541 2.598e-05 0.001422
85 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 6 541 2.598e-05 0.001422
86 POSITIVE REGULATION OF LIPID TRANSPORT 3 51 2.669e-05 0.001444
87 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 4 156 2.81e-05 0.001503
88 POSITIVE REGULATION OF RESPONSE TO WOUNDING 4 162 3.257e-05 0.001722
89 CELL SUBSTRATE ADHESION 4 164 3.417e-05 0.001787
90 COFACTOR BIOSYNTHETIC PROCESS 4 166 3.583e-05 0.001853
91 MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS 4 172 4.117e-05 0.002105
92 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 5 351 4.197e-05 0.002123
93 GLYCEROLIPID METABOLIC PROCESS 5 356 4.49e-05 0.002246
94 OXIDATION REDUCTION PROCESS 7 898 4.681e-05 0.002317
95 ION TRANSPORT 8 1262 5.127e-05 0.002485
96 CIRCULATORY SYSTEM PROCESS 5 366 5.122e-05 0.002485
97 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 7 926 5.692e-05 0.00273
98 REGULATION OF PHAGOCYTOSIS 3 68 6.341e-05 0.003011
99 REGULATION OF TRANSFERASE ACTIVITY 7 946 6.518e-05 0.003064
100 POSITIVE REGULATION OF MEMBRANE INVAGINATION 2 11 6.914e-05 0.003154
101 LOW DENSITY LIPOPROTEIN PARTICLE CLEARANCE 2 11 6.914e-05 0.003154
102 POSITIVE REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 11 6.914e-05 0.003154
103 SINGLE ORGANISM CATABOLIC PROCESS 7 957 7.014e-05 0.003168
104 SULFUR COMPOUND BIOSYNTHETIC PROCESS 4 203 7.843e-05 0.003509
105 CARBOXYLIC ACID CATABOLIC PROCESS 4 205 8.147e-05 0.003576
106 ORGANIC ACID CATABOLIC PROCESS 4 205 8.147e-05 0.003576
107 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 12 8.291e-05 0.003605
108 WHITE FAT CELL DIFFERENTIATION 2 13 9.792e-05 0.004032
109 LIPOPROTEIN TRANSPORT 2 13 9.792e-05 0.004032
110 REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 13 9.792e-05 0.004032
111 LIPOPROTEIN LOCALIZATION 2 13 9.792e-05 0.004032
112 NEGATIVE REGULATION OF CARDIAC MUSCLE CELL APOPTOTIC PROCESS 2 13 9.792e-05 0.004032
113 REGULATION OF MEMBRANE INVAGINATION 2 13 9.792e-05 0.004032
114 NEGATIVE REGULATION OF PHOSPHORYLATION 5 422 0.0001004 0.004098
115 RESPONSE TO ABIOTIC STIMULUS 7 1024 0.0001075 0.004348
116 POSITIVE REGULATION OF CHOLESTEROL EFFLUX 2 14 0.0001142 0.004464
117 RESPONSE TO LOW DENSITY LIPOPROTEIN PARTICLE 2 14 0.0001142 0.004464
118 POSITIVE REGULATION OF FATTY ACID OXIDATION 2 14 0.0001142 0.004464
119 LINOLEIC ACID METABOLIC PROCESS 2 14 0.0001142 0.004464
120 POSITIVE REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 2 15 0.0001316 0.005042
121 REGULATION OF FATTY ACID METABOLIC PROCESS 3 87 0.0001322 0.005042
122 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 3 87 0.0001322 0.005042
123 REGULATION OF RESPONSE TO STRESS 8 1468 0.0001492 0.005645
124 WOUND HEALING 5 470 0.0001663 0.006238
125 NEGATIVE REGULATION OF LIPID STORAGE 2 17 0.0001703 0.006238
126 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 2 17 0.0001703 0.006238
127 NEGATIVE REGULATION OF STRIATED MUSCLE CELL APOPTOTIC PROCESS 2 17 0.0001703 0.006238
128 NEGATIVE REGULATION OF KINASE ACTIVITY 4 250 0.000175 0.006363
129 POSITIVE REGULATION OF KINASE ACTIVITY 5 482 0.0001871 0.006696
130 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 5 482 0.0001871 0.006696
131 REGULATION OF KINASE ACTIVITY 6 776 0.0001917 0.006757
132 RETINOIC ACID RECEPTOR SIGNALING PATHWAY 2 18 0.0001914 0.006757
133 FIBRIL ORGANIZATION 2 19 0.0002138 0.007479
134 COENZYME METABOLIC PROCESS 4 265 0.0002188 0.007597
135 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 4 270 0.000235 0.007669
136 REGULATION OF FAT CELL DIFFERENTIATION 3 106 0.0002372 0.007669
137 REGULATION OF CHOLESTEROL EFFLUX 2 20 0.0002374 0.007669
138 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 6 799 0.0002246 0.007669
139 ORGANIC ACID BIOSYNTHETIC PROCESS 4 270 0.000235 0.007669
140 REGULATION OF GLUCOSE METABOLIC PROCESS 3 106 0.0002372 0.007669
141 RESPONSE TO VITAMIN A 2 20 0.0002374 0.007669
142 FAT CELL DIFFERENTIATION 3 106 0.0002372 0.007669
143 RESPONSE TO LIPOPROTEIN PARTICLE 2 20 0.0002374 0.007669
144 POSITIVE REGULATION OF LIPID STORAGE 2 20 0.0002374 0.007669
145 CELLULAR RESPONSE TO PEPTIDE 4 274 0.0002485 0.00792
146 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 4 274 0.0002485 0.00792
147 LIPID HOMEOSTASIS 3 110 0.0002646 0.008208
148 PLASMA LIPOPROTEIN PARTICLE CLEARANCE 2 21 0.0002622 0.008208
149 TRIGLYCERIDE CATABOLIC PROCESS 2 21 0.0002622 0.008208
150 POSITIVE REGULATION OF CELL DIFFERENTIATION 6 823 0.0002637 0.008208
151 CELL MOTILITY 6 835 0.0002851 0.008728
152 LOCALIZATION OF CELL 6 835 0.0002851 0.008728
153 REGULATION OF STRIATED MUSCLE CELL APOPTOTIC PROCESS 2 22 0.0002882 0.008764
154 FATTY ACID BIOSYNTHETIC PROCESS 3 114 0.0002939 0.008824
155 REGULATION OF PHOSPHORUS METABOLIC PROCESS 8 1618 0.0002929 0.008824
156 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 4 289 0.0003044 0.00908
157 RESPONSE TO NITROGEN COMPOUND 6 859 0.0003321 0.009815
158 FOCAL ADHESION ASSEMBLY 2 24 0.0003438 0.009815
159 CELL MATRIX ADHESION 3 119 0.0003334 0.009815
160 MACROMOLECULAR COMPLEX REMODELING 2 24 0.0003438 0.009815
161 CELL SUBSTRATE ADHERENS JUNCTION ASSEMBLY 2 24 0.0003438 0.009815
162 PLASMA LIPOPROTEIN PARTICLE REMODELING 2 24 0.0003438 0.009815
163 PROTEIN LIPID COMPLEX REMODELING 2 24 0.0003438 0.009815
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 5 48 2.093e-09 7.42e-07
2 LONG CHAIN FATTY ACID COA LIGASE ACTIVITY 4 13 9.435e-10 7.42e-07
3 FATTY ACID LIGASE ACTIVITY 4 16 2.396e-09 7.42e-07
4 STEROID HORMONE RECEPTOR ACTIVITY 5 59 6.069e-09 1.41e-06
5 FATTY ACID BINDING 4 31 4.096e-08 7.61e-06
6 LIGASE ACTIVITY FORMING CARBON SULFUR BONDS 4 40 1.181e-07 1.829e-05
7 LIPID BINDING 8 657 4.116e-07 5.463e-05
8 LONG CHAIN FATTY ACID BINDING 3 14 4.796e-07 5.569e-05
9 MONOCARBOXYLIC ACID BINDING 4 65 8.588e-07 8.864e-05
10 ORGANIC ACID BINDING 5 209 3.429e-06 0.0003186
11 LOW DENSITY LIPOPROTEIN RECEPTOR ACTIVITY 2 13 9.792e-05 0.00827
NumGOOverlapSizeP ValueAdj. P Value
1 MICROBODY PART 4 93 3.625e-06 0.002117
2 MICROBODY 4 134 1.545e-05 0.004513
3 MICROBODY MEMBRANE 3 58 3.933e-05 0.007657
4 OUTER MEMBRANE 4 190 6.066e-05 0.008857

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03320_PPAR_signaling_pathway 23 70 5.592e-59 1.007e-56
2 hsa04920_Adipocytokine_signaling_pathway 9 68 2.755e-17 2.479e-15
3 hsa00071_Fatty_acid_metabolism 4 43 1.592e-07 9.551e-06
4 hsa04146_Peroxisome 4 79 1.886e-06 8.485e-05
5 hsa01040_Biosynthesis_of_unsaturated_fatty_acids 2 21 0.0002622 0.009438
6 hsa04910_Insulin_signaling_pathway 2 138 0.01088 0.3263
7 hsa04145_Phagosome 2 156 0.01374 0.3532
8 hsa04510_Focal_adhesion 2 200 0.02193 0.4097

Quest ID: c0d25d496b8a4cbadc92cbc2e3b167fe