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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-195-5p OTUB1 -1.45 0 0.64 0 miRNATAP -0.13 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 14 873 1.862e-11 6.615e-08
2 PROTEIN MODIFICATION BY SMALL PROTEIN REMOVAL 8 133 2.844e-11 6.615e-08
3 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 12 720 5.04e-10 7.817e-07
4 PROTEIN CATABOLIC PROCESS 10 579 1.39e-08 1.617e-05
5 DNA REPAIR 9 480 4.209e-08 3.264e-05
6 CELLULAR RESPONSE TO STRESS 14 1565 3.739e-08 3.264e-05
7 NON RECOMBINATIONAL REPAIR 5 70 8.499e-08 5.649e-05
8 MACROMOLECULE CATABOLIC PROCESS 11 926 1.041e-07 6.055e-05
9 DOUBLE STRAND BREAK REPAIR 6 165 2.184e-07 0.0001129
10 CATABOLIC PROCESS 13 1773 1.387e-06 0.0006265
11 PROTEOLYSIS 11 1208 1.481e-06 0.0006265
12 DNA METABOLIC PROCESS 9 758 1.969e-06 0.0007637
13 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 5 145 3.215e-06 0.001151
14 CELLULAR CATABOLIC PROCESS 11 1322 3.572e-06 0.001182
15 CELL CYCLE ARREST 5 154 4.318e-06 0.001182
16 PROTEIN K48 LINKED DEUBIQUITINATION 3 20 4.164e-06 0.001182
17 ESTABLISHMENT OF PROTEIN LOCALIZATION TO GOLGI 3 20 4.164e-06 0.001182
18 REGULATION OF DNA REPAIR 4 75 6.057e-06 0.001566
19 PROTEIN K63 LINKED DEUBIQUITINATION 3 24 7.36e-06 0.001712
20 RETROGRADE TRANSPORT VESICLE RECYCLING WITHIN GOLGI 3 24 7.36e-06 0.001712
21 REGULATION OF CELLULAR RESPONSE TO STRESS 8 691 9.827e-06 0.002177
22 REGULATION OF DNA METABOLIC PROCESS 6 340 1.441e-05 0.003048
23 SOMATIC CELL DNA RECOMBINATION 3 33 1.965e-05 0.003657
24 SOMATIC DIVERSIFICATION OF IMMUNE RECEPTORS VIA GERMLINE RECOMBINATION WITHIN A SINGLE LOCUS 3 33 1.965e-05 0.003657
25 PROTEIN LOCALIZATION TO GOLGI APPARATUS 3 33 1.965e-05 0.003657
26 MULTICELLULAR ORGANISM REPRODUCTION 8 768 2.112e-05 0.00378
27 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 4 111 2.866e-05 0.00494
28 GAMETE GENERATION 7 595 3.506e-05 0.005827
29 SOMATIC DIVERSIFICATION OF IMMUNE RECEPTORS 3 42 4.094e-05 0.006568
30 INTRA GOLGI VESICLE MEDIATED TRANSPORT 3 47 5.751e-05 0.008632
31 NEGATIVE REGULATION OF CELL CYCLE 6 433 5.591e-05 0.008632
32 MULTI ORGANISM REPRODUCTIVE PROCESS 8 891 6.09e-05 0.008855
NumGOOverlapSizeP ValueAdj. P Value
1 THIOL DEPENDENT UBIQUITIN SPECIFIC PROTEASE ACTIVITY 8 73 2.08e-13 1.933e-10
2 CYSTEINE TYPE PEPTIDASE ACTIVITY 9 184 9.068e-12 3.118e-09
3 UBIQUITIN LIKE PROTEIN SPECIFIC PROTEASE ACTIVITY 8 117 1.007e-11 3.118e-09
4 UBIQUITIN LIKE PROTEIN BINDING 7 121 7.393e-10 1.717e-07
5 PEPTIDASE ACTIVITY 9 663 6.483e-07 0.0001204
6 K63 LINKED POLYUBIQUITIN BINDING 3 19 3.543e-06 0.0005486
7 ZINC ION BINDING 10 1155 7.955e-06 0.001056
8 POLYUBIQUITIN BINDING 3 42 4.094e-05 0.004378
9 TRANSITION METAL ION BINDING 10 1400 4.241e-05 0.004378
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 2 124 0.01675 0.213
2 Autophagy_animal_hsa04140 2 128 0.01778 0.213
3 FoxO_signaling_pathway_hsa04068 2 132 0.01884 0.213
4 Apelin_signaling_pathway_hsa04371 2 137 0.0202 0.213
5 Apoptosis_hsa04210 2 138 0.02048 0.213
6 Cellular_senescence_hsa04218 2 160 0.02696 0.2337

Quest ID: c43ad5e7b35622fe4d423f6c397ad198