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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-145-5p APH1A -2.62 0 0.59 0 miRNAWalker2 validate -0.15 0 NA
2 hsa-miR-330-3p CREBBP 1.76 0 -0.59 0 MirTarget; PITA; miRNATAP -0.11 2.0E-5 NA
3 hsa-miR-330-5p CREBBP 2.22 0 -0.59 0 miRanda -0.13 0 NA
4 hsa-miR-103a-3p DLL1 1.51 0 -1.56 0 miRNATAP -0.45 0 NA
5 hsa-miR-107 DLL1 1.81 0 -1.56 0 PITA; miRanda; miRNATAP -0.45 0 NA
6 hsa-miR-130b-3p DLL1 3.42 0 -1.56 0 miRNATAP -0.23 0 NA
7 hsa-miR-142-3p DLL1 2.07 0 -1.56 0 miRanda -0.16 0.00012 NA
8 hsa-miR-146b-5p DLL1 1.31 0 -1.56 0 miRanda -0.24 1.0E-5 NA
9 hsa-miR-15a-5p DLL1 1.78 0 -1.56 0 miRNATAP -0.43 0 NA
10 hsa-miR-15b-5p DLL1 2.5 0 -1.56 0 miRNATAP -0.41 0 NA
11 hsa-miR-16-5p DLL1 1.88 0 -1.56 0 miRNATAP -0.32 0 NA
12 hsa-miR-193a-3p DLL1 0.42 0.05317 -1.56 0 miRanda -0.2 0.00019 NA
13 hsa-miR-24-3p DLL1 0.86 0 -1.56 0 miRNATAP -0.23 0.00282 NA
14 hsa-miR-301a-3p DLL1 1.94 0 -1.56 0 miRNATAP -0.21 6.0E-5 NA
15 hsa-miR-320b DLL1 1.1 0 -1.56 0 miRanda -0.15 0.00549 NA
16 hsa-miR-326 DLL1 1.07 6.0E-5 -1.56 0 miRanda -0.15 0.0006 NA
17 hsa-miR-330-5p DLL1 2.22 0 -1.56 0 miRanda -0.3 0 NA
18 hsa-miR-34a-5p DLL1 0.94 1.0E-5 -1.56 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.15 0.00402 22438124 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells
19 hsa-miR-362-3p DLL1 0.54 0.00242 -1.56 0 miRanda -0.13 0.04186 NA
20 hsa-miR-362-5p DLL1 0.45 0.02925 -1.56 0 PITA; TargetScan; miRNATAP -0.14 0.0137 NA
21 hsa-miR-423-3p DLL1 1.7 0 -1.56 0 PITA -0.43 0 NA
22 hsa-miR-429 DLL1 5.04 0 -1.56 0 miRanda; miRNATAP -0.12 6.0E-5 NA
23 hsa-miR-454-3p DLL1 1.53 0 -1.56 0 miRNATAP -0.24 0.00028 NA
24 hsa-miR-486-5p DLL1 0.63 0.03561 -1.56 0 miRanda -0.12 0.0019 NA
25 hsa-miR-576-5p DLL1 1.31 0 -1.56 0 PITA -0.24 0.00014 NA
26 hsa-miR-589-5p DLL1 1.56 0 -1.56 0 miRNATAP -0.41 0 NA
27 hsa-miR-590-3p DLL1 1.73 0 -1.56 0 PITA; miRanda; mirMAP -0.27 0 NA
28 hsa-miR-15a-5p DLL4 1.78 0 -0.95 0 miRNATAP -0.27 0 NA
29 hsa-miR-15b-5p DLL4 2.5 0 -0.95 0 miRNATAP -0.28 0 NA
30 hsa-miR-16-5p DLL4 1.88 0 -0.95 0 miRNATAP -0.19 3.0E-5 NA
31 hsa-miR-30c-5p DLL4 0.72 1.0E-5 -0.95 0 miRNATAP -0.21 0 NA
32 hsa-miR-30d-5p DLL4 0.58 0.00023 -0.95 0 miRNATAP -0.17 0.00064 NA
33 hsa-miR-429 DLL4 5.04 0 -0.95 0 miRanda -0.13 0 NA
34 hsa-miR-484 DLL4 2.63 0 -0.95 0 miRNATAP -0.18 0 NA
35 hsa-miR-1254 DTX1 2.69 0 -0.47 0.0544 miRNATAP -0.13 0.00238 NA
36 hsa-miR-188-5p DTX1 1.83 0 -0.47 0.0544 PITA -0.11 0.02266 NA
37 hsa-miR-421 DTX1 2.1 0 -0.47 0.0544 PITA; miRanda; miRNATAP -0.11 0.03186 NA
38 hsa-miR-107 DTX3 1.81 0 -0.84 0 miRanda -0.16 0.0013 NA
39 hsa-miR-185-5p DTX3 1.98 0 -0.84 0 MirTarget -0.28 0 NA
40 hsa-miR-320a DTX3L 0.5 0.00226 0.46 0.00401 miRanda -0.11 0.02285 NA
41 hsa-miR-493-5p DTX3L 0.01 0.95887 0.46 0.00401 MirTarget -0.11 0.00011 NA
42 hsa-miR-495-3p DTX3L -1.05 0.00017 0.46 0.00401 mirMAP -0.1 0.0002 NA
43 hsa-miR-484 DVL2 2.63 0 -0.44 6.0E-5 miRNAWalker2 validate -0.1 5.0E-5 NA
44 hsa-let-7a-5p DVL3 0.1 0.43289 0.26 0.00454 TargetScan -0.11 0.00261 NA
45 hsa-miR-106b-5p EP300 2.18 0 -0.21 0.12793 miRNATAP -0.14 5.0E-5 NA
46 hsa-miR-25-3p EP300 1.36 0 -0.21 0.12793 miRNAWalker2 validate -0.14 0.00108 NA
47 hsa-miR-26a-5p EP300 -0.63 0 -0.21 0.12793 miRNATAP -0.14 0.01247 NA
48 hsa-miR-339-5p EP300 1.79 0 -0.21 0.12793 miRanda -0.1 0.00056 NA
49 hsa-miR-342-3p EP300 0.91 0 -0.21 0.12793 MirTarget; PITA; miRanda; miRNATAP -0.13 0.00146 NA
50 hsa-miR-361-3p EP300 0.7 0 -0.21 0.12793 PITA -0.13 0.00226 NA
51 hsa-miR-421 EP300 2.1 0 -0.21 0.12793 miRanda -0.11 0.00011 NA
52 hsa-miR-92a-3p EP300 1.69 0 -0.21 0.12793 miRNAWalker2 validate -0.13 0.00063 NA
53 hsa-let-7a-3p HDAC2 1.03 0 0.47 7.0E-5 mirMAP -0.13 2.0E-5 NA
54 hsa-let-7b-3p HDAC2 0.35 0.07056 0.47 7.0E-5 mirMAP -0.16 0 NA
55 hsa-miR-126-5p HDAC2 -0.59 3.0E-5 0.47 7.0E-5 mirMAP -0.16 6.0E-5 NA
56 hsa-miR-145-5p HDAC2 -2.62 0 0.47 7.0E-5 miRNAWalker2 validate -0.13 0 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis
57 hsa-miR-195-3p HDAC2 -1.78 0 0.47 7.0E-5 mirMAP -0.1 0 NA
58 hsa-miR-22-5p HDAC2 1.63 0 0.47 7.0E-5 mirMAP -0.13 0 NA
59 hsa-miR-30a-3p HDAC2 0.31 0.22984 0.47 7.0E-5 mirMAP -0.11 0 NA
60 hsa-miR-30b-5p HDAC2 0.36 0.02886 0.47 7.0E-5 mirMAP -0.18 0 NA
61 hsa-miR-30c-5p HDAC2 0.72 1.0E-5 0.47 7.0E-5 mirMAP -0.12 0.00034 NA
62 hsa-miR-30e-3p HDAC2 0.12 0.34565 0.47 7.0E-5 mirMAP -0.18 2.0E-5 NA
63 hsa-miR-92a-3p HES1 1.69 0 0.33 0.06313 miRNAWalker2 validate -0.17 0.00087 NA
64 hsa-miR-15b-5p HES5 2.5 0 0.03 0.94494 mirMAP -0.28 0.00442 NA
65 hsa-miR-501-5p HES5 1.63 0 0.03 0.94494 PITA; miRNATAP -0.2 0.02265 NA
66 hsa-miR-128-3p JAG1 1.97 0 -0.55 0.00271 MirTarget -0.26 0 NA
67 hsa-miR-146b-5p JAG1 1.31 0 -0.55 0.00271 miRanda -0.12 0.00349 NA
68 hsa-miR-16-1-3p JAG1 2.09 0 -0.55 0.00271 MirTarget -0.15 0.00014 NA
69 hsa-miR-186-5p JAG1 1.01 0 -0.55 0.00271 MirTarget; miRNATAP -0.25 6.0E-5 NA
70 hsa-miR-335-3p JAG1 1.32 0 -0.55 0.00271 MirTarget -0.17 2.0E-5 NA
71 hsa-miR-361-3p JAG1 0.7 0 -0.55 0.00271 miRNATAP -0.25 2.0E-5 NA
72 hsa-miR-590-5p JAG1 1.46 0 -0.55 0.00271 MirTarget; PITA; miRanda; miRNATAP -0.19 4.0E-5 NA
73 hsa-miR-93-3p JAG1 2.62 0 -0.55 0.00271 MirTarget; miRNATAP -0.1 0.00625 NA
74 hsa-miR-940 JAG1 3.49 0 -0.55 0.00271 MirTarget; PITA; miRNATAP -0.14 0 NA
75 hsa-miR-98-5p JAG1 1.06 0 -0.55 0.00271 miRNAWalker2 validate -0.22 0.00043 NA
76 hsa-miR-140-3p JAG2 -1.44 0 0.67 0.00018 miRNATAP -0.17 0.00075 NA
77 hsa-miR-106b-5p KAT2B 2.18 0 -1.35 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.29 0 NA
78 hsa-miR-125a-3p KAT2B 0.77 6.0E-5 -1.35 0 miRanda -0.16 0.00067 NA
79 hsa-miR-17-5p KAT2B 2.27 0 -1.35 0 MirTarget; TargetScan -0.25 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
80 hsa-miR-181a-5p KAT2B 0.97 0 -1.35 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.13 0.00457 NA
81 hsa-miR-181b-5p KAT2B 1.3 0 -1.35 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.2 2.0E-5 NA
82 hsa-miR-192-5p KAT2B 1.98 0 -1.35 0 miRNAWalker2 validate -0.13 0.0001 NA
83 hsa-miR-19a-3p KAT2B 1.85 0 -1.35 0 miRNAWalker2 validate -0.19 1.0E-5 NA
84 hsa-miR-19b-3p KAT2B 1.34 0 -1.35 0 miRNAWalker2 validate -0.24 1.0E-5 NA
85 hsa-miR-20a-3p KAT2B 1.64 0 -1.35 0 MirTarget -0.2 0 NA
86 hsa-miR-20a-5p KAT2B 1.51 0 -1.35 0 MirTarget -0.14 0.00075 NA
87 hsa-miR-25-3p KAT2B 1.36 0 -1.35 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.29 0 NA
88 hsa-miR-26b-5p KAT2B 0.3 0.04319 -1.35 0 miRNAWalker2 validate -0.13 0.03161 NA
89 hsa-miR-29a-5p KAT2B -0.16 0.45228 -1.35 0 MirTarget -0.1 0.0224 NA
90 hsa-miR-32-5p KAT2B 1.62 0 -1.35 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.15 0.00313 NA
91 hsa-miR-429 KAT2B 5.04 0 -1.35 0 miRanda -0.11 1.0E-5 NA
92 hsa-miR-590-3p KAT2B 1.73 0 -1.35 0 MirTarget; miRanda; mirMAP; miRNATAP -0.11 0.02433 NA
93 hsa-miR-590-5p KAT2B 1.46 0 -1.35 0 miRanda -0.14 0.00286 NA
94 hsa-miR-92a-3p KAT2B 1.69 0 -1.35 0 miRNAWalker2 validate; MirTarget -0.27 0 NA
95 hsa-miR-93-5p KAT2B 2.58 0 -1.35 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.2 0 NA
96 hsa-miR-129-5p LFNG -0.71 0.023 0.74 0.005 MirTarget -0.13 0.00109 NA
97 hsa-miR-146b-5p LFNG 1.31 0 0.74 0.005 PITA; miRanda; miRNATAP -0.16 0.00643 NA
98 hsa-miR-338-5p LFNG 0.59 0.04471 0.74 0.005 PITA; miRNATAP -0.15 0.00032 NA
99 hsa-miR-330-5p MAML2 2.22 0 -0.6 0.00855 miRanda -0.13 0.00774 NA
100 hsa-miR-421 MAML2 2.1 0 -0.6 0.00855 miRanda -0.13 0.00417 NA
101 hsa-miR-125a-3p MAML3 0.77 6.0E-5 -1.31 0 miRanda -0.16 0.00076 NA
102 hsa-miR-3065-3p MAML3 2.26 0 -1.31 0 miRNATAP -0.13 0 NA
103 hsa-miR-326 MAML3 1.07 6.0E-5 -1.31 0 miRanda -0.22 0 NA
104 hsa-miR-330-5p MAML3 2.22 0 -1.31 0 miRanda -0.4 0 NA
105 hsa-miR-339-5p MAML3 1.79 0 -1.31 0 miRanda -0.22 0 NA
106 hsa-miR-361-5p MAML3 0.51 0.00011 -1.31 0 miRanda -0.27 0.00011 NA
107 hsa-miR-421 MAML3 2.1 0 -1.31 0 miRanda -0.29 0 NA
108 hsa-miR-590-3p MAML3 1.73 0 -1.31 0 miRanda -0.26 0 NA
109 hsa-miR-590-3p MFNG 1.73 0 -1.02 0 miRanda -0.11 0.02151 NA
110 hsa-miR-939-5p MFNG 2.15 0 -1.02 0 MirTarget -0.19 0 NA
111 hsa-miR-30d-5p NCOR2 0.58 0.00023 -0.09 0.44858 miRNATAP -0.11 0.0019 NA
112 hsa-miR-140-5p NCSTN -0.89 0 0.88 0 MirTarget; PITA; miRanda; miRNATAP -0.14 6.0E-5 NA
113 hsa-miR-101-3p NOTCH1 -1.48 0 0.05 0.78359 MirTarget -0.12 0.01324 NA
114 hsa-miR-129-5p NOTCH1 -0.71 0.023 0.05 0.78359 miRNAWalker2 validate -0.11 1.0E-5 NA
115 hsa-miR-24-3p NOTCH1 0.86 0 0.05 0.78359 miRNAWalker2 validate; miRTarBase -0.12 0.02474 NA
116 hsa-miR-30c-5p NOTCH1 0.72 1.0E-5 0.05 0.78359 miRNATAP -0.1 0.03243 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations
117 hsa-miR-30d-5p NOTCH1 0.58 0.00023 0.05 0.78359 miRNATAP -0.15 0.0029 NA
118 hsa-miR-32-5p NOTCH1 1.62 0 0.05 0.78359 miRNATAP -0.1 0.01874 NA
119 hsa-miR-92a-3p NOTCH1 1.69 0 0.05 0.78359 miRNATAP -0.11 0.02256 NA
120 hsa-miR-92b-3p NOTCH1 2.31 0 0.05 0.78359 miRNATAP -0.11 0.00018 NA
121 hsa-miR-103a-3p NOTCH2 1.51 0 -0.68 0 MirTarget -0.12 0.00227 NA
122 hsa-miR-107 NOTCH2 1.81 0 -0.68 0 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.16 1.0E-5 NA
123 hsa-miR-15a-5p NOTCH2 1.78 0 -0.68 0 MirTarget -0.17 4.0E-5 NA
124 hsa-miR-15b-5p NOTCH2 2.5 0 -0.68 0 MirTarget -0.15 2.0E-5 NA
125 hsa-miR-16-5p NOTCH2 1.88 0 -0.68 0 miRNAWalker2 validate; MirTarget -0.13 0.0014 NA
126 hsa-miR-185-5p NOTCH2 1.98 0 -0.68 0 MirTarget -0.12 0.00074 NA
127 hsa-miR-200b-5p NOTCH2 4.84 0 -0.68 0 mirMAP -0.11 0 NA
128 hsa-miR-330-5p NOTCH2 2.22 0 -0.68 0 miRanda -0.11 0.00046 NA
129 hsa-miR-340-5p NOTCH2 1.35 0 -0.68 0 mirMAP -0.15 0.00011 NA
130 hsa-miR-423-5p NOTCH2 0.88 0 -0.68 0 MirTarget -0.17 0.00011 NA
131 hsa-miR-744-5p NOTCH2 1.84 0 -0.68 0 miRNAWalker2 validate -0.11 0.00089 NA
132 hsa-miR-660-5p NOTCH3 0.21 0.2672 0.66 0.00025 MirTarget -0.16 0.00062 NA
133 hsa-miR-125a-3p NOTCH4 0.77 6.0E-5 -1.02 0 miRanda -0.14 0.00013 NA
134 hsa-miR-146b-5p NOTCH4 1.31 0 -1.02 0 miRanda -0.19 0 NA
135 hsa-miR-18a-3p NOTCH4 3.54 0 -1.02 0 miRNAWalker2 validate -0.22 0 NA
136 hsa-miR-193a-3p NOTCH4 0.42 0.05317 -1.02 0 miRanda -0.1 0.00115 NA
137 hsa-miR-324-5p NOTCH4 2.15 0 -1.02 0 miRanda -0.23 0 NA
138 hsa-miR-330-5p NOTCH4 2.22 0 -1.02 0 miRanda -0.2 0 NA
139 hsa-miR-342-3p NOTCH4 0.91 0 -1.02 0 miRanda -0.15 0.00057 NA
140 hsa-miR-421 NOTCH4 2.1 0 -1.02 0 miRanda -0.16 0 NA
141 hsa-miR-429 NOTCH4 5.04 0 -1.02 0 miRNATAP -0.14 0 NA
142 hsa-miR-491-5p NOTCH4 1.23 0 -1.02 0 miRanda -0.16 0 NA
143 hsa-miR-103a-3p NUMB 1.51 0 -0.16 0.07538 miRNAWalker2 validate -0.14 0 NA
144 hsa-miR-107 NUMB 1.81 0 -0.16 0.07538 miRanda -0.1 1.0E-5 NA
145 hsa-miR-125a-3p NUMB 0.77 6.0E-5 -0.16 0.07538 miRanda -0.12 0 NA
146 hsa-miR-146b-5p NUMB 1.31 0 -0.16 0.07538 PITA; miRanda; miRNATAP -0.1 0 NA
147 hsa-miR-141-3p NUMBL 4.68 0 -0.92 0 TargetScan -0.1 0 NA
148 hsa-miR-194-3p NUMBL 2.11 0 -0.92 0 MirTarget -0.14 0 NA
149 hsa-miR-34a-5p NUMBL 0.94 1.0E-5 -0.92 0 MirTarget; miRNATAP -0.12 0.00015 NA
150 hsa-let-7e-5p RBPJ 0.82 0 -0.15 0.26186 miRNATAP -0.13 0.00678 NA
NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH SIGNALING PATHWAY 21 114 1.456e-41 6.776e-38
2 REGULATION OF NOTCH SIGNALING PATHWAY 11 67 1.307e-20 3.04e-17
3 NOTCH RECEPTOR PROCESSING 8 16 1.179e-19 1.828e-16
4 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 9 34 5.204e-19 6.053e-16
5 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 16 750 1.164e-15 1.083e-12
6 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 10 153 1.343e-14 9.488e-12
7 CELL FATE COMMITMENT 11 227 1.427e-14 9.488e-12
8 EPITHELIAL CELL FATE COMMITMENT 6 15 3.315e-14 1.928e-11
9 NEURON FATE COMMITMENT 8 67 5.683e-14 2.938e-11
10 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 6.726e-14 3.13e-11
11 POSITIVE REGULATION OF GENE EXPRESSION 19 1733 1.288e-13 5.449e-11
12 DNA TEMPLATED TRANSCRIPTION INITIATION 10 202 2.226e-13 8.631e-11
13 EPITHELIUM DEVELOPMENT 15 945 9.336e-13 3.342e-10
14 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 1004 2.232e-12 7.419e-10
15 AUDITORY RECEPTOR CELL DIFFERENTIATION 6 28 2.462e-12 7.637e-10
16 REGULATION OF CELL DEVELOPMENT 14 836 3.482e-12 1.013e-09
17 ORGAN MORPHOGENESIS 14 841 3.773e-12 1.033e-09
18 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 18 1805 4.371e-12 1.13e-09
19 MORPHOGENESIS OF AN EPITHELIUM 11 400 6.939e-12 1.699e-09
20 EAR DEVELOPMENT 9 195 7.931e-12 1.845e-09
21 EMBRYO DEVELOPMENT 14 894 8.575e-12 1.9e-09
22 TUBE DEVELOPMENT 12 552 9.545e-12 2.019e-09
23 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 724 1.118e-11 2.081e-09
24 HAIR CELL DIFFERENTIATION 6 35 1.053e-11 2.081e-09
25 PATTERN SPECIFICATION PROCESS 11 418 1.115e-11 2.081e-09
26 HEART MORPHOGENESIS 9 212 1.681e-11 3.009e-09
27 NEUROGENESIS 16 1402 1.776e-11 3.061e-09
28 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 5 16 2.309e-11 3.837e-09
29 CELL FATE DETERMINATION 6 43 3.923e-11 6.295e-09
30 REGULATION OF CELL DIFFERENTIATION 16 1492 4.535e-11 7.034e-09
31 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1784 5.16e-11 7.745e-09
32 TISSUE DEVELOPMENT 16 1518 5.878e-11 8.548e-09
33 NEURONAL STEM CELL POPULATION MAINTENANCE 5 19 6.127e-11 8.639e-09
34 POSITIVE REGULATION OF CELL COMMUNICATION 16 1532 6.746e-11 9.233e-09
35 ARTERY MORPHOGENESIS 6 51 1.149e-10 1.486e-08
36 MECHANORECEPTOR DIFFERENTIATION 6 51 1.149e-10 1.486e-08
37 TISSUE MORPHOGENESIS 11 533 1.501e-10 1.888e-08
38 CARDIAC CHAMBER MORPHOGENESIS 7 104 1.546e-10 1.893e-08
39 POSITIVE REGULATION OF RESPONSE TO STIMULUS 17 1929 1.778e-10 2.121e-08
40 REGULATION OF NEURON DIFFERENTIATION 11 554 2.263e-10 2.632e-08
41 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 7 111 2.454e-10 2.785e-08
42 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 8 191 2.921e-10 3.236e-08
43 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 13 957 3.567e-10 3.86e-08
44 IMMUNE SYSTEM DEVELOPMENT 11 582 3.815e-10 4.034e-08
45 NEUROEPITHELIAL CELL DIFFERENTIATION 6 63 4.283e-10 4.429e-08
46 REGIONALIZATION 9 311 5.087e-10 5.145e-08
47 CARDIOVASCULAR SYSTEM DEVELOPMENT 12 788 5.794e-10 5.616e-08
48 CIRCULATORY SYSTEM DEVELOPMENT 12 788 5.794e-10 5.616e-08
49 LYMPHOCYTE DIFFERENTIATION 8 209 5.975e-10 5.673e-08
50 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 12 801 6.982e-10 6.479e-08
51 TUBE MORPHOGENESIS 9 323 7.101e-10 6.479e-08
52 HEART DEVELOPMENT 10 466 8.478e-10 7.443e-08
53 MAINTENANCE OF CELL NUMBER 7 132 8.336e-10 7.443e-08
54 LYMPHOCYTE ACTIVATION 9 342 1.174e-09 1.011e-07
55 ARTERY DEVELOPMENT 6 75 1.254e-09 1.061e-07
56 EPIDERMAL CELL DIFFERENTIATION 7 142 1.392e-09 1.157e-07
57 SENSORY ORGAN DEVELOPMENT 10 493 1.46e-09 1.192e-07
58 CARDIAC CHAMBER DEVELOPMENT 7 144 1.535e-09 1.211e-07
59 EPITHELIAL CELL DIFFERENTIATION 10 495 1.518e-09 1.211e-07
60 NEURON DIFFERENTIATION 12 874 1.88e-09 1.458e-07
61 REGULATION OF TIMING OF CELL DIFFERENTIATION 4 12 2.019e-09 1.515e-07
62 REGULATION OF DEVELOPMENT HETEROCHRONIC 4 12 2.019e-09 1.515e-07
63 EPIDERMIS DEVELOPMENT 8 253 2.702e-09 1.995e-07
64 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 4 13 2.913e-09 2.118e-07
65 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 262 3.555e-09 2.44e-07
66 B CELL DIFFERENTIATION 6 89 3.566e-09 2.44e-07
67 SEGMENTATION 6 89 3.566e-09 2.44e-07
68 EMBRYONIC MORPHOGENESIS 10 539 3.441e-09 2.44e-07
69 ENDOTHELIUM DEVELOPMENT 6 90 3.817e-09 2.574e-07
70 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 10 554 4.475e-09 2.975e-07
71 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 740 4.746e-09 3.11e-07
72 LEUKOCYTE ACTIVATION 9 414 6.23e-09 4.026e-07
73 LEUKOCYTE DIFFERENTIATION 8 292 8.309e-09 5.296e-07
74 MATURE B CELL DIFFERENTIATION 4 17 9.655e-09 6.042e-07
75 CARDIAC SEPTUM MORPHOGENESIS 5 49 9.738e-09 6.042e-07
76 NEGATIVE REGULATION OF CELL DEVELOPMENT 8 303 1.109e-08 6.614e-07
77 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 1.081e-08 6.614e-07
78 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 1.104e-08 6.614e-07
79 REGULATION OF EMBRYONIC DEVELOPMENT 6 114 1.595e-08 9.395e-07
80 NEPHRON DEVELOPMENT 6 115 1.681e-08 9.778e-07
81 OUTFLOW TRACT MORPHOGENESIS 5 56 1.937e-08 1.112e-06
82 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 2.398e-08 1.361e-06
83 AORTA MORPHOGENESIS 4 22 2.952e-08 1.655e-06
84 B CELL ACTIVATION 6 132 3.844e-08 2.129e-06
85 BLOOD VESSEL MORPHOGENESIS 8 364 4.6e-08 2.518e-06
86 ENDOTHELIAL CELL DIFFERENTIATION 5 72 6.976e-08 3.774e-06
87 REGULATION OF CELL PROLIFERATION 13 1496 7.807e-08 4.176e-06
88 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 11 983 8.825e-08 4.666e-06
89 CELL ACTIVATION 9 568 9.475e-08 4.92e-06
90 REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 4 29 9.516e-08 4.92e-06
91 RENAL TUBULE DEVELOPMENT 5 78 1.046e-07 5.348e-06
92 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 4 32 1.436e-07 7.186e-06
93 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 4 32 1.436e-07 7.186e-06
94 CARDIAC SEPTUM DEVELOPMENT 5 85 1.613e-07 7.986e-06
95 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 437 1.871e-07 9.073e-06
96 POSITIVE REGULATION OF CELL DIFFERENTIATION 10 823 1.872e-07 9.073e-06
97 ANGIOGENESIS 7 293 2.056e-07 9.864e-06
98 B CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 35 2.085e-07 9.898e-06
99 UROGENITAL SYSTEM DEVELOPMENT 7 299 2.359e-07 1.109e-05
100 NEPHRON EPITHELIUM DEVELOPMENT 5 93 2.535e-07 1.18e-05
101 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 37 2.624e-07 1.209e-05
102 IMMUNE SYSTEM PROCESS 14 1984 2.676e-07 1.221e-05
103 VASCULATURE DEVELOPMENT 8 469 3.204e-07 1.447e-05
104 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 3.358e-07 1.49e-05
105 POSITIVE REGULATION OF CELL DEVELOPMENT 8 472 3.363e-07 1.49e-05
106 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 100 3.646e-07 1.6e-05
107 ANTERIOR POSTERIOR PATTERN SPECIFICATION 6 194 3.771e-07 1.64e-05
108 AORTA DEVELOPMENT 4 41 4.007e-07 1.71e-05
109 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 11 1142 4.005e-07 1.71e-05
110 CELL DEVELOPMENT 12 1426 4.258e-07 1.801e-05
111 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 4 43 4.873e-07 2.008e-05
112 MORPHOGENESIS OF AN EPITHELIAL SHEET 4 43 4.873e-07 2.008e-05
113 CARDIAC VENTRICLE DEVELOPMENT 5 106 4.877e-07 2.008e-05
114 LOOP OF HENLE DEVELOPMENT 3 11 4.984e-07 2.017e-05
115 VENTRICULAR TRABECULA MYOCARDIUM MORPHOGENESIS 3 11 4.984e-07 2.017e-05
116 REGULATION OF EPIDERMAL CELL DIFFERENTIATION 4 45 5.871e-07 2.355e-05
117 REGULATION OF STEM CELL DIFFERENTIATION 5 113 6.705e-07 2.667e-05
118 FOREBRAIN DEVELOPMENT 7 357 7.783e-07 3.069e-05
119 GLOMERULUS DEVELOPMENT 4 49 8.314e-07 3.251e-05
120 NEGATIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 3 13 8.622e-07 3.316e-05
121 NEGATIVE REGULATION OF EPIDERMAL CELL DIFFERENTIATION 3 13 8.622e-07 3.316e-05
122 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 6 229 9.958e-07 3.798e-05
123 KIDNEY EPITHELIUM DEVELOPMENT 5 125 1.106e-06 4.185e-05
124 POSITIVE REGULATION OF BINDING 5 127 1.197e-06 4.491e-05
125 NEGATIVE REGULATION OF HEMOPOIESIS 5 128 1.244e-06 4.631e-05
126 N TERMINAL PROTEIN AMINO ACID ACETYLATION 3 15 1.369e-06 4.992e-05
127 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 3 15 1.369e-06 4.992e-05
128 REGULATION OF ORGAN MORPHOGENESIS 6 242 1.373e-06 4.992e-05
129 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 1.683e-06 5.978e-05
130 NEGATIVE REGULATION OF EPIDERMIS DEVELOPMENT 3 16 1.683e-06 5.978e-05
131 GLIAL CELL DIFFERENTIATION 5 136 1.679e-06 5.978e-05
132 REGULATION OF GLIAL CELL DIFFERENTIATION 4 59 1.767e-06 6.23e-05
133 SEGMENT SPECIFICATION 3 17 2.042e-06 7.143e-05
134 SOMITOGENESIS 4 62 2.159e-06 7.443e-05
135 CARDIAC VENTRICLE MORPHOGENESIS 4 62 2.159e-06 7.443e-05
136 REGULATION OF EPIDERMIS DEVELOPMENT 4 63 2.303e-06 7.881e-05
137 NEURAL TUBE DEVELOPMENT 5 149 2.631e-06 8.936e-05
138 FOREBRAIN GENERATION OF NEURONS 4 66 2.778e-06 9.301e-05
139 MUSCLE STRUCTURE DEVELOPMENT 7 432 2.768e-06 9.301e-05
140 KIDNEY VASCULATURE DEVELOPMENT 3 19 2.904e-06 9.582e-05
141 RENAL SYSTEM VASCULATURE DEVELOPMENT 3 19 2.904e-06 9.582e-05
142 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 2.952e-06 9.672e-05
143 REGULATION OF BINDING 6 283 3.397e-06 0.0001104
144 CENTRAL NERVOUS SYSTEM DEVELOPMENT 9 872 3.418e-06 0.0001104
145 SKIN EPIDERMIS DEVELOPMENT 4 71 3.726e-06 0.0001196
146 POSITIVE REGULATION OF STAT CASCADE 4 73 4.165e-06 0.0001319
147 POSITIVE REGULATION OF JAK STAT CASCADE 4 73 4.165e-06 0.0001319
148 SOMATIC STEM CELL DIVISION 3 22 4.601e-06 0.0001446
149 REGULATION OF BMP SIGNALING PATHWAY 4 77 5.158e-06 0.0001611
150 SOMITE DEVELOPMENT 4 78 5.431e-06 0.0001685
151 NEGATIVE REGULATION OF GENE EXPRESSION 11 1493 5.595e-06 0.0001724
152 GLIOGENESIS 5 175 5.781e-06 0.000177
153 NEGATIVE REGULATION OF HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 3 24 6.034e-06 0.0001835
154 REGULATION OF HEMOPOIESIS 6 314 6.171e-06 0.0001864
155 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 11 1517 6.525e-06 0.0001959
156 HEAD DEVELOPMENT 8 709 7.02e-06 0.0002094
157 HEART TRABECULA MORPHOGENESIS 3 26 7.736e-06 0.0002264
158 NEGATIVE REGULATION OF GLIAL CELL DIFFERENTIATION 3 26 7.736e-06 0.0002264
159 N TERMINAL PROTEIN AMINO ACID MODIFICATION 3 26 7.736e-06 0.0002264
160 TISSUE REMODELING 4 87 8.395e-06 0.0002442
161 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 513 8.552e-06 0.0002472
162 REGULATION OF ASTROCYTE DIFFERENTIATION 3 27 8.694e-06 0.0002482
163 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 3 27 8.694e-06 0.0002482
164 REGULATION OF GLIOGENESIS 4 90 9.607e-06 0.0002726
165 NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY 3 28 9.727e-06 0.0002727
166 REGULATION OF SPROUTING ANGIOGENESIS 3 28 9.727e-06 0.0002727
167 RESPIRATORY SYSTEM DEVELOPMENT 5 197 1.028e-05 0.0002864
168 STEM CELL DIVISION 3 29 1.084e-05 0.0002984
169 REGULATION OF HEART MORPHOGENESIS 3 29 1.084e-05 0.0002984
170 CARDIOCYTE DIFFERENTIATION 4 96 1.241e-05 0.0003397
171 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 207 1.306e-05 0.0003555
172 CARDIAC ATRIUM DEVELOPMENT 3 31 1.331e-05 0.00036
173 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 98 1.347e-05 0.0003623
174 SKIN DEVELOPMENT 5 211 1.433e-05 0.0003832
175 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 1.467e-05 0.0003856
176 POSITIVE REGULATION OF GLIAL CELL DIFFERENTIATION 3 32 1.467e-05 0.0003856
177 BLOOD VESSEL REMODELING 3 32 1.467e-05 0.0003856
178 HEART VALVE DEVELOPMENT 3 34 1.766e-05 0.0004617
179 POSITIVE REGULATION OF CELL PROLIFERATION 8 814 1.917e-05 0.0004984
180 CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 3 36 2.103e-05 0.0005436
181 NEGATIVE REGULATION OF GLIOGENESIS 3 37 2.286e-05 0.0005813
182 MYOBLAST DIFFERENTIATION 3 37 2.286e-05 0.0005813
183 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 3 37 2.286e-05 0.0005813
184 SENSORY ORGAN MORPHOGENESIS 5 239 2.609e-05 0.0006598
185 POSITIVE REGULATION OF VIRAL TRANSCRIPTION 3 39 2.684e-05 0.0006607
186 TRABECULA MORPHOGENESIS 3 39 2.684e-05 0.0006607
187 ASTROCYTE DIFFERENTIATION 3 39 2.684e-05 0.0006607
188 COCHLEA DEVELOPMENT 3 39 2.684e-05 0.0006607
189 EMBRYONIC ORGAN DEVELOPMENT 6 406 2.65e-05 0.0006607
190 REGULATION OF HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 3 41 3.124e-05 0.000765
191 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 3.249e-05 0.0007915
192 NEGATIVE REGULATION OF CELL PROLIFERATION 7 643 3.669e-05 0.0008892
193 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 3 44 3.869e-05 0.0009329
194 TUBE FORMATION 4 129 3.975e-05 0.0009534
195 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 3 45 4.142e-05 0.0009882
196 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 4 134 4.612e-05 0.001089
197 MESENCHYMAL CELL DIFFERENTIATION 4 134 4.612e-05 0.001089
198 POSITIVE REGULATION OF GLIOGENESIS 3 47 4.723e-05 0.00111
199 MUSCLE TISSUE DEVELOPMENT 5 275 5.096e-05 0.001192
200 MUSCLE ORGAN DEVELOPMENT 5 277 5.275e-05 0.001227
201 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 139 5.321e-05 0.001232
202 EMBRYONIC ORGAN MORPHOGENESIS 5 279 5.458e-05 0.001257
203 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 5.943e-05 0.001362
204 REGULATION OF JAK STAT CASCADE 4 144 6.106e-05 0.001386
205 REGULATION OF STAT CASCADE 4 144 6.106e-05 0.001386
206 CARDIAC MUSCLE TISSUE MORPHOGENESIS 3 54 7.174e-05 0.00162
207 RHYTHMIC PROCESS 5 298 7.455e-05 0.001676
208 REGULATION OF MUSCLE CELL DIFFERENTIATION 4 152 7.535e-05 0.001685
209 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 8.001e-05 0.001781
210 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 4 156 8.333e-05 0.001846
211 RESPONSE TO OXYGEN LEVELS 5 311 9.118e-05 0.002011
212 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 162 9.645e-05 0.002107
213 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 162 9.645e-05 0.002107
214 EMBRYONIC DIGIT MORPHOGENESIS 3 61 0.0001034 0.002237
215 REGULATION OF VIRAL TRANSCRIPTION 3 61 0.0001034 0.002237
216 EMBRYONIC HEART TUBE MORPHOGENESIS 3 62 0.0001085 0.002337
217 ENDOCARDIUM DEVELOPMENT 2 11 0.0001186 0.002498
218 NEGATIVE REGULATION OF SPROUTING ANGIOGENESIS 2 11 0.0001186 0.002498
219 NEGATIVE REGULATION OF GLIAL CELL PROLIFERATION 2 11 0.0001186 0.002498
220 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 2 11 0.0001186 0.002498
221 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 0.0001186 0.002498
222 REGULATION OF PROTEIN ACETYLATION 3 64 0.0001193 0.0025
223 CELLULAR RESPONSE TO RETINOIC ACID 3 65 0.0001249 0.002607
224 CARDIAC LEFT VENTRICLE MORPHOGENESIS 2 12 0.0001422 0.00289
225 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.0001422 0.00289
226 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 2 12 0.0001422 0.00289
227 DISTAL TUBULE DEVELOPMENT 2 12 0.0001422 0.00289
228 LATERAL VENTRICLE DEVELOPMENT 2 12 0.0001422 0.00289
229 POSITIVE REGULATION OF ASTROCYTE DIFFERENTIATION 2 12 0.0001422 0.00289
230 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN 3 68 0.0001429 0.002891
231 COVALENT CHROMATIN MODIFICATION 5 345 0.0001483 0.002987
232 MUSCLE ORGAN MORPHOGENESIS 3 70 0.0001558 0.003124
233 CELL FATE SPECIFICATION 3 71 0.0001625 0.003245
234 EPITHELIAL CELL DEVELOPMENT 4 186 0.0001643 0.003266
235 NEURONAL STEM CELL DIVISION 2 13 0.0001679 0.003269
236 VASCULAR SMOOTH MUSCLE CELL DIFFERENTIATION 2 13 0.0001679 0.003269
237 LEFT RIGHT AXIS SPECIFICATION 2 13 0.0001679 0.003269
238 CARDIOBLAST DIFFERENTIATION 2 13 0.0001679 0.003269
239 NEUROBLAST DIVISION 2 13 0.0001679 0.003269
240 POSITIVE REGULATION OF PROTEIN BINDING 3 73 0.0001765 0.003407
241 EMBRYONIC HEART TUBE DEVELOPMENT 3 73 0.0001765 0.003407
242 MESENCHYME DEVELOPMENT 4 190 0.0001782 0.003413
243 STEM CELL DIFFERENTIATION 4 190 0.0001782 0.003413
244 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 2 14 0.0001957 0.003733
245 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 1135 0.0002001 0.0038
246 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 5 372 0.0002106 0.003983
247 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 8 1152 0.0002216 0.004175
248 RESPONSE TO MURAMYL DIPEPTIDE 2 15 0.0002256 0.004216
249 ENDOCARDIAL CUSHION FORMATION 2 15 0.0002256 0.004216
250 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1492 0.0002372 0.004414
251 METANEPHROS DEVELOPMENT 3 81 0.0002401 0.004451
252 HAIR CYCLE 3 83 0.0002581 0.004709
253 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 2 16 0.0002576 0.004709
254 MOLTING CYCLE 3 83 0.0002581 0.004709
255 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 2 16 0.0002576 0.004709
256 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 85 0.0002768 0.004992
257 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 213 0.0002758 0.004992
258 POSITIVE REGULATION OF CHROMATIN MODIFICATION 3 85 0.0002768 0.004992
259 GLAND DEVELOPMENT 5 395 0.0002779 0.004992
260 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 2 17 0.0002917 0.00522
261 CELLULAR COMPONENT MORPHOGENESIS 7 900 0.0002993 0.005336
262 LABYRINTHINE LAYER BLOOD VESSEL DEVELOPMENT 2 18 0.0003279 0.0058
263 PERICARDIUM DEVELOPMENT 2 18 0.0003279 0.0058
264 POSITIVE REGULATION OF VIRAL PROCESS 3 92 0.0003495 0.00616
265 TELENCEPHALON DEVELOPMENT 4 228 0.0003572 0.006271
266 REGULATION OF DNA BINDING 3 93 0.0003608 0.006311
267 REGULATION OF CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 19 0.0003661 0.006356
268 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 19 0.0003661 0.006356
269 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 4 236 0.000407 0.007013
270 METANEPHRIC EPITHELIUM DEVELOPMENT 2 20 0.0004064 0.007013
271 MUSCLE CELL DIFFERENTIATION 4 237 0.0004135 0.0071
272 CELL PROLIFERATION 6 672 0.0004192 0.007161
273 POSITIVE REGULATION OF GROWTH 4 238 0.0004202 0.007161
274 METANEPHRIC NEPHRON MORPHOGENESIS 2 21 0.0004487 0.007484
275 INNER EAR RECEPTOR STEREOCILIUM ORGANIZATION 2 21 0.0004487 0.007484
276 LEFT RIGHT PATTERN FORMATION 2 21 0.0004487 0.007484
277 REGULATION OF GLIAL CELL PROLIFERATION 2 21 0.0004487 0.007484
278 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 2 21 0.0004487 0.007484
279 COCHLEA MORPHOGENESIS 2 21 0.0004487 0.007484
280 KERATINOCYTE DIFFERENTIATION 3 101 0.0004596 0.007638
281 NEURON DEVELOPMENT 6 687 0.0004714 0.007805
282 ENDOCARDIAL CUSHION MORPHOGENESIS 2 22 0.0004932 0.007995
283 REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 103 0.0004868 0.007995
284 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 2 22 0.0004932 0.007995
285 MODULATION OF TRANSCRIPTION IN OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 2 22 0.0004932 0.007995
286 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 2 22 0.0004932 0.007995
287 REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 103 0.0004868 0.007995
288 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 1656 0.0005159 0.008335
289 SPINAL CORD DEVELOPMENT 3 106 0.0005294 0.008523
290 ESTABLISHMENT OF EPITHELIAL CELL POLARITY 2 23 0.0005396 0.00857
291 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 23 0.0005396 0.00857
292 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS 2 23 0.0005396 0.00857
293 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 2 23 0.0005396 0.00857
294 LEUKOCYTE CELL CELL ADHESION 4 255 0.0005449 0.008595
295 RESPONSE TO RETINOIC ACID 3 107 0.0005441 0.008595
296 NEGATIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 2 24 0.0005881 0.009152
297 NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION 2 24 0.0005881 0.009152
298 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 2 24 0.0005881 0.009152
299 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 2 24 0.0005881 0.009152
300 LUNG CELL DIFFERENTIATION 2 25 0.0006387 0.009906
NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH BINDING 8 18 4e-19 3.716e-16
2 TRANSCRIPTION FACTOR BINDING 10 524 2.625e-09 1.219e-06
3 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 10 588 7.904e-09 2.448e-06
4 TRANSCRIPTION COACTIVATOR ACTIVITY 7 296 2.203e-07 5.117e-05
5 RECEPTOR BINDING 12 1476 6.171e-07 0.0001147
6 CHROMATIN BINDING 7 435 2.897e-06 0.0004486
7 CALCIUM ION BINDING 8 697 6.194e-06 0.000822
8 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 4 104 1.704e-05 0.001979
9 CORE PROMOTER BINDING 4 152 7.535e-05 0.007777
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMATIN 7 441 3.172e-06 0.001852
2 NUCLEOPLASM PART 8 708 6.948e-06 0.002029
3 NUCLEAR CHROMATIN 5 291 6.663e-05 0.009728
4 GOLGI MEMBRANE 7 703 6.461e-05 0.009728

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Notch_signaling_pathway_hsa04330 30 48 1.846e-84 9.597e-83
2 Wnt_signaling_pathway_hsa04310 4 146 6.443e-05 0.001675
3 Cell_cycle_hsa04110 3 124 0.0008357 0.01449
4 Adherens_junction_hsa04520 2 72 0.005209 0.06771
5 TGF_beta_signaling_pathway_hsa04350 2 84 0.007025 0.07306
6 HIF_1_signaling_pathway_hsa04066 2 100 0.009829 0.08518
7 FoxO_signaling_pathway_hsa04068 2 132 0.01667 0.1052
8 Apelin_signaling_pathway_hsa04371 2 137 0.01788 0.1052
9 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.01837 0.1052
10 mTOR_signaling_pathway_hsa04150 2 151 0.02145 0.1052
11 Hippo_signaling_pathway_hsa04390 2 154 0.02225 0.1052
12 Jak_STAT_signaling_pathway_hsa04630 2 162 0.02445 0.106
13 cAMP_signaling_pathway_hsa04024 2 198 0.03538 0.1415

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

HAND2-AS1

hsa-miR-103a-3p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-146b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-301a-3p;hsa-miR-320b;hsa-miR-326;hsa-miR-330-5p;hsa-miR-486-5p;hsa-miR-576-5p;hsa-miR-589-5p 14 DLL1 Sponge network -3.916 0.01209 -1.564 0 0.286

Quest ID: c5991c121d146de08198a3976312d40b