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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7g-5p DUSP1 0.02 0.79164 -2.1 0 miRNATAP -0.25 0.00071 NA
2 hsa-miR-141-3p DUSP1 3 0 -2.1 0 TargetScan -0.44 0 NA
3 hsa-miR-148a-3p DUSP1 0.71 0 -2.1 0 miRNATAP -0.37 0 NA
4 hsa-miR-186-5p DUSP1 -0.43 1.0E-5 -2.1 0 mirMAP -0.21 0.00023 NA
5 hsa-miR-200b-3p DUSP1 2.12 0 -2.1 0 MirTarget; TargetScan -0.37 0 NA
6 hsa-miR-200c-3p DUSP1 2.07 0 -2.1 0 MirTarget; miRNATAP -0.46 0 NA
7 hsa-miR-324-3p DUSP1 0.4 0.00034 -2.1 0 MirTarget -0.51 0 NA
8 hsa-miR-331-5p DUSP1 0.68 0 -2.1 0 PITA; miRNATAP -0.47 0 NA
9 hsa-miR-425-3p DUSP1 0.75 0 -2.1 0 MirTarget -0.4 0 NA
10 hsa-miR-429 DUSP1 2.84 0 -2.1 0 MirTarget; PITA; miRanda; miRNATAP -0.37 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 115 1977 5.368e-48 2.498e-44
2 PROTEIN PHOSPHORYLATION 82 944 1.55e-45 3.606e-42
3 PHOSPHORYLATION 90 1228 3.088e-44 4.79e-41
4 INTRACELLULAR SIGNAL TRANSDUCTION 88 1572 5.727e-34 6.662e-31
5 REGULATION OF TRANSFERASE ACTIVITY 68 946 3.69e-32 3.434e-29
6 REGULATION OF PROTEIN MODIFICATION PROCESS 88 1710 3.257e-31 2.526e-28
7 CELL CYCLE 76 1316 8.289e-30 5.51e-27
8 REGULATION OF CELL CYCLE 65 949 1.872e-29 1.089e-26
9 MITOTIC CELL CYCLE 58 766 1.946e-28 1.006e-25
10 CELL CYCLE PHASE TRANSITION 35 255 8.68e-26 4.039e-23
11 REGULATION OF KINASE ACTIVITY 54 776 1.146e-24 4.555e-22
12 CELL CYCLE PROCESS 63 1081 1.175e-24 4.555e-22
13 PROTEIN AUTOPHOSPHORYLATION 30 192 6.578e-24 2.354e-21
14 REGULATION OF CELL DEATH 72 1472 9.294e-24 3.089e-21
15 CELL CYCLE G2 M PHASE TRANSITION 26 138 5.095e-23 1.565e-20
16 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 61 1087 5.382e-23 1.565e-20
17 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 46 616 2.925e-22 8.006e-20
18 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 70 1492 5.034e-22 1.301e-19
19 PEPTIDYL AMINO ACID MODIFICATION 52 841 2.053e-21 5.027e-19
20 REGULATION OF CELL CYCLE PROCESS 43 558 2.359e-21 5.227e-19
21 REGULATION OF PHOSPHORUS METABOLIC PROCESS 72 1618 2.318e-21 5.227e-19
22 REGULATION OF RESPONSE TO STRESS 66 1468 1.006e-19 2.099e-17
23 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 43 616 1.038e-19 2.099e-17
24 REGULATION OF ORGANELLE ORGANIZATION 58 1178 4.186e-19 8.115e-17
25 CELLULAR RESPONSE TO STRESS 67 1565 6.537e-19 1.217e-16
26 POSITIVE REGULATION OF RESPONSE TO STIMULUS 75 1929 7.102e-19 1.271e-16
27 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 37 470 9.311e-19 1.605e-16
28 REGULATION OF CELLULAR RESPONSE TO STRESS 44 691 1.251e-18 2.078e-16
29 RESPONSE TO OXYGEN CONTAINING COMPOUND 62 1381 1.86e-18 2.824e-16
30 NEGATIVE REGULATION OF CELL DEATH 49 872 1.881e-18 2.824e-16
31 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 56 1135 1.771e-18 2.824e-16
32 REGULATION OF MITOTIC CELL CYCLE 36 468 6.048e-18 8.795e-16
33 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 67 1656 1.232e-17 1.737e-15
34 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 70 1805 1.757e-17 2.405e-15
35 CELL DEATH 51 1001 2.098e-17 2.79e-15
36 REGULATION OF CELL PROLIFERATION 63 1496 2.166e-17 2.8e-15
37 PEPTIDYL SERINE MODIFICATION 22 148 2.493e-17 3.135e-15
38 POSITIVE REGULATION OF MOLECULAR FUNCTION 69 1791 4.535e-17 5.553e-15
39 CELL CYCLE CHECKPOINT 24 194 6.514e-17 7.772e-15
40 CELL DIVISION 34 460 1.821e-16 2.069e-14
41 REGULATION OF CELL CYCLE PHASE TRANSITION 29 321 1.823e-16 2.069e-14
42 NEGATIVE REGULATION OF CELL CYCLE 33 433 2.134e-16 2.364e-14
43 POSITIVE REGULATION OF GENE EXPRESSION 66 1733 4.756e-16 5.146e-14
44 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 68 1848 8.46e-16 8.947e-14
45 RESPONSE TO ENDOGENOUS STIMULUS 59 1450 1.373e-15 1.42e-13
46 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 52 1152 1.493e-15 1.51e-13
47 POSITIVE REGULATION OF CATALYTIC ACTIVITY 60 1518 2.777e-15 2.749e-13
48 RESPONSE TO HORMONE 45 893 3.227e-15 3.128e-13
49 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 36 573 3.572e-15 3.392e-13
50 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 26 280 3.723e-15 3.465e-13
51 PROTEIN DEPHOSPHORYLATION 22 190 5.491e-15 5.01e-13
52 REGULATION OF DNA METABOLIC PROCESS 28 340 6.642e-15 5.943e-13
53 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 28 351 1.484e-14 1.303e-12
54 RESPONSE TO NITROGEN COMPOUND 43 859 1.83e-14 1.577e-12
55 POSITIVE REGULATION OF CELL DEATH 36 605 1.881e-14 1.591e-12
56 RESPONSE TO ABIOTIC STIMULUS 47 1024 2.362e-14 1.963e-12
57 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 31 448 2.602e-14 2.124e-12
58 IMMUNE SYSTEM PROCESS 68 1984 2.831e-14 2.271e-12
59 POSITIVE REGULATION OF KINASE ACTIVITY 32 482 3.047e-14 2.403e-12
60 RESPONSE TO ORGANIC CYCLIC COMPOUND 44 917 3.867e-14 2.949e-12
61 NEGATIVE REGULATION OF MOLECULAR FUNCTION 48 1079 3.86e-14 2.949e-12
62 DNA INTEGRITY CHECKPOINT 19 146 4.841e-14 3.633e-12
63 NEGATIVE REGULATION OF CELL CYCLE PROCESS 22 214 6.623e-14 4.892e-12
64 POSITIVE REGULATION OF CELL COMMUNICATION 57 1532 2.105e-13 1.507e-11
65 POSITIVE REGULATION OF CELL CYCLE 26 332 2.098e-13 1.507e-11
66 REGULATION OF BINDING 24 283 3.299e-13 2.326e-11
67 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 31 498 4.393e-13 3.051e-11
68 REGULATION OF PROTEOLYSIS 37 711 4.772e-13 3.265e-11
69 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 28 404 4.85e-13 3.27e-11
70 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 39 799 7.74e-13 5.145e-11
71 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 53 1395 7.915e-13 5.187e-11
72 MITOTIC NUCLEAR DIVISION 26 361 1.447e-12 9.349e-11
73 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 55 1517 1.729e-12 1.102e-10
74 POSITIVE REGULATION OF IMMUNE RESPONSE 32 563 2.062e-12 1.297e-10
75 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 44 1036 2.54e-12 1.555e-10
76 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 44 1036 2.54e-12 1.555e-10
77 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 36 720 3.26e-12 1.97e-10
78 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 25 352 5.417e-12 3.231e-10
79 CELL PROLIFERATION 34 672 1.004e-11 5.914e-10
80 ACTIVATION OF IMMUNE RESPONSE 27 427 1.097e-11 6.383e-10
81 CELL MOTILITY 38 835 1.283e-11 7.28e-10
82 LOCALIZATION OF CELL 38 835 1.283e-11 7.28e-10
83 REGULATION OF CHROMOSOME ORGANIZATION 22 278 1.313e-11 7.359e-10
84 CELLULAR RESPONSE TO NITROGEN COMPOUND 29 505 1.886e-11 1.045e-09
85 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 34 689 1.982e-11 1.085e-09
86 REGULATION OF CATABOLIC PROCESS 35 731 2.249e-11 1.217e-09
87 DEPHOSPHORYLATION 22 286 2.292e-11 1.226e-09
88 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 14 96 2.319e-11 1.226e-09
89 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 14 97 2.679e-11 1.401e-09
90 RESPONSE TO RADIATION 26 413 2.982e-11 1.542e-09
91 REGULATION OF CELLULAR PROTEIN LOCALIZATION 30 552 3.23e-11 1.651e-09
92 REGULATION OF RNA STABILITY 16 139 3.398e-11 1.682e-09
93 POSITIVE REGULATION OF DNA METABOLIC PROCESS 18 185 3.397e-11 1.682e-09
94 MITOTIC CELL CYCLE CHECKPOINT 16 139 3.398e-11 1.682e-09
95 NEGATIVE REGULATION OF GENE EXPRESSION 52 1493 3.539e-11 1.733e-09
96 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 17 162 3.632e-11 1.76e-09
97 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 38 867 3.87e-11 1.857e-09
98 PEPTIDYL TYROSINE DEPHOSPHORYLATION 14 100 4.09e-11 1.942e-09
99 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 24 360 5.506e-11 2.588e-09
100 REGULATION OF PROTEIN CATABOLIC PROCESS 25 393 5.855e-11 2.724e-09
101 REGULATION OF CELLULAR LOCALIZATION 47 1277 5.93e-11 2.732e-09
102 REGULATION OF CELL DIVISION 21 272 6.201e-11 2.829e-09
103 ORGANELLE FISSION 28 496 6.4e-11 2.891e-09
104 REGULATION OF APOPTOTIC SIGNALING PATHWAY 24 363 6.536e-11 2.924e-09
105 CELLULAR RESPONSE TO PEPTIDE 21 274 7.11e-11 3.151e-09
106 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 18 196 8.899e-11 3.906e-09
107 RESPONSE TO PEPTIDE 25 404 1.052e-10 4.577e-09
108 REGULATION OF CELL CYCLE ARREST 14 108 1.18e-10 5.084e-09
109 NEUROGENESIS 49 1402 1.301e-10 5.555e-09
110 REGULATION OF PROTEIN LOCALIZATION 39 950 1.435e-10 6.071e-09
111 CELL CYCLE G1 S PHASE TRANSITION 14 111 1.715e-10 7.127e-09
112 G1 S TRANSITION OF MITOTIC CELL CYCLE 14 111 1.715e-10 7.127e-09
113 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 21 289 1.912e-10 7.875e-09
114 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 40 1008 2.216e-10 9.044e-09
115 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 22 323 2.404e-10 9.727e-09
116 REGULATION OF INNATE IMMUNE RESPONSE 23 357 2.773e-10 1.112e-08
117 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 12 77 2.875e-10 1.143e-08
118 RESPONSE TO LIPID 37 888 2.991e-10 1.179e-08
119 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 15 139 3.566e-10 1.394e-08
120 POSITIVE REGULATION OF CATABOLIC PROCESS 24 395 3.674e-10 1.425e-08
121 POSITIVE REGULATION OF PROTEOLYSIS 23 363 3.846e-10 1.479e-08
122 ERBB SIGNALING PATHWAY 12 79 3.916e-10 1.494e-08
123 REGULATION OF IMMUNE RESPONSE 36 858 4.43e-10 1.676e-08
124 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 20 274 4.857e-10 1.823e-08
125 RESPONSE TO REACTIVE OXYGEN SPECIES 17 191 4.905e-10 1.826e-08
126 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 19 246 5.177e-10 1.912e-08
127 POSITIVE REGULATION OF CELL CYCLE PROCESS 19 247 5.545e-10 2.032e-08
128 REGULATION OF PROTEIN BINDING 16 168 5.93e-10 2.156e-08
129 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 9 36 5.978e-10 2.156e-08
130 CELLULAR RESPONSE TO INSULIN STIMULUS 15 146 7.15e-10 2.521e-08
131 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 15 146 7.15e-10 2.521e-08
132 RESPONSE TO LIGHT STIMULUS 20 280 7.103e-10 2.521e-08
133 CELLULAR RESPONSE TO HORMONE STIMULUS 28 552 7.337e-10 2.567e-08
134 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 16 171 7.707e-10 2.676e-08
135 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 17 199 9.266e-10 3.194e-08
136 RESPONSE TO UV 14 126 9.471e-10 3.24e-08
137 REGULATION OF CYTOKINE PRODUCTION 28 563 1.141e-09 3.874e-08
138 REGULATION OF MAP KINASE ACTIVITY 21 319 1.159e-09 3.909e-08
139 LOCOMOTION 41 1114 1.206e-09 4.038e-08
140 RESPONSE TO OXIDATIVE STRESS 22 352 1.216e-09 4.042e-08
141 ERBB2 SIGNALING PATHWAY 9 39 1.301e-09 4.293e-08
142 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 31 684 1.31e-09 4.293e-08
143 ACTIVATION OF INNATE IMMUNE RESPONSE 17 204 1.358e-09 4.418e-08
144 NEGATIVE REGULATION OF PHOSPHORYLATION 24 422 1.382e-09 4.466e-08
145 REGULATION OF LIGASE ACTIVITY 14 130 1.435e-09 4.605e-08
146 RESPONSE TO INSULIN 17 205 1.464e-09 4.665e-08
147 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 19 263 1.59e-09 4.992e-08
148 POSITIVE REGULATION OF CELL PROLIFERATION 34 814 1.598e-09 4.992e-08
149 FC RECEPTOR SIGNALING PATHWAY 17 206 1.577e-09 4.992e-08
150 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 541 2.139e-09 6.59e-08
151 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 541 2.139e-09 6.59e-08
152 REGULATION OF MAPK CASCADE 30 660 2.311e-09 7.073e-08
153 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 34 829 2.543e-09 7.734e-08
154 PEPTIDYL TYROSINE MODIFICATION 16 186 2.646e-09 7.994e-08
155 REGULATION OF CELL DIFFERENTIATION 48 1492 3.22e-09 9.667e-08
156 REGULATION OF NUCLEAR DIVISION 15 163 3.327e-09 9.84e-08
157 CYTOSKELETON ORGANIZATION 34 838 3.341e-09 9.84e-08
158 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 9 43 3.31e-09 9.84e-08
159 REGULATION OF NEURON PROJECTION DEVELOPMENT 23 408 3.66e-09 1.071e-07
160 DNA METABOLIC PROCESS 32 758 3.92e-09 1.14e-07
161 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 16 192 4.193e-09 1.212e-07
162 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 51 1672 5.672e-09 1.629e-07
163 MITOTIC DNA INTEGRITY CHECKPOINT 12 100 6.323e-09 1.805e-07
164 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 14 147 7.199e-09 2.042e-07
165 REGULATION OF CYTOSKELETON ORGANIZATION 25 502 9.117e-09 2.571e-07
166 CHROMOSOME ORGANIZATION 37 1009 9.516e-09 2.667e-07
167 REGULATION OF INTRACELLULAR TRANSPORT 28 621 9.792e-09 2.728e-07
168 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 34 876 1.012e-08 2.804e-07
169 REGULATION OF CELL DEVELOPMENT 33 836 1.136e-08 3.127e-07
170 REGULATION OF IMMUNE SYSTEM PROCESS 45 1403 1.201e-08 3.288e-07
171 POSITIVE REGULATION OF MAP KINASE ACTIVITY 16 207 1.234e-08 3.358e-07
172 RESPONSE TO EXTERNAL STIMULUS 53 1821 1.323e-08 3.579e-07
173 REGULATION OF NEURON DIFFERENTIATION 26 554 1.525e-08 4.102e-07
174 RESPONSE TO INORGANIC SUBSTANCE 24 479 1.633e-08 4.368e-07
175 REGULATION OF CELL PROJECTION ORGANIZATION 26 558 1.764e-08 4.691e-07
176 REGULATION OF TYPE I INTERFERON PRODUCTION 12 111 2.094e-08 5.536e-07
177 REGULATION OF DNA REPLICATION 14 161 2.321e-08 6.101e-07
178 MITOCHONDRIAL MEMBRANE ORGANIZATION 11 92 2.845e-08 7.437e-07
179 G1 DNA DAMAGE CHECKPOINT 10 73 3.263e-08 8.483e-07
180 REGULATION OF CELL ADHESION 27 629 5.037e-08 1.302e-06
181 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 41 1275 5.548e-08 1.426e-06
182 POSITIVE REGULATION OF DEFENSE RESPONSE 20 364 6.066e-08 1.551e-06
183 POSITIVE REGULATION OF MITOTIC CELL CYCLE 12 123 6.662e-08 1.694e-06
184 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 38 1142 7.614e-08 1.925e-06
185 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 13 150 7.728e-08 1.944e-06
186 POSITIVE REGULATION OF CYTOKINE PRODUCTION 20 370 7.922e-08 1.982e-06
187 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 11 103 9.317e-08 2.318e-06
188 POSITIVE REGULATION OF BINDING 12 127 9.515e-08 2.343e-06
189 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 12 127 9.515e-08 2.343e-06
190 CENTROSOME CYCLE 8 45 9.817e-08 2.404e-06
191 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 14 181 1.016e-07 2.475e-06
192 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 15 213 1.217e-07 2.95e-06
193 CELLULAR RESPONSE TO OXIDATIVE STRESS 14 184 1.246e-07 3.005e-06
194 REGULATION OF GLUCOSE METABOLIC PROCESS 11 106 1.255e-07 3.01e-06
195 REGULATION OF CHROMOSOME SEGREGATION 10 85 1.435e-07 3.407e-06
196 POSITIVE REGULATION OF CELL CYCLE ARREST 10 85 1.435e-07 3.407e-06
197 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 29 750 1.463e-07 3.457e-06
198 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 20 387 1.639e-07 3.851e-06
199 CELLULAR RESPONSE TO UV 9 66 1.678e-07 3.903e-06
200 RESPONSE TO HYDROGEN PEROXIDE 11 109 1.675e-07 3.903e-06
201 NEGATIVE REGULATION OF KINASE ACTIVITY 16 250 1.714e-07 3.969e-06
202 PROTEIN LOCALIZATION 50 1805 1.752e-07 4.03e-06
203 G2 DNA DAMAGE CHECKPOINT 7 33 1.758e-07 4.03e-06
204 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 10 87 1.794e-07 4.092e-06
205 POSITIVE REGULATION OF LIGASE ACTIVITY 11 110 1.84e-07 4.155e-06
206 RESPONSE TO CYTOKINE 28 714 1.831e-07 4.155e-06
207 REGULATION OF TELOMERE MAINTENANCE 9 67 1.916e-07 4.307e-06
208 REGULATION OF PROTEIN STABILITY 15 221 1.968e-07 4.402e-06
209 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 10 88 2.001e-07 4.455e-06
210 REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 8 50 2.313e-07 5.124e-06
211 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 23 514 2.516e-07 5.548e-06
212 RESPONSE TO ALCOHOL 19 362 2.66e-07 5.838e-06
213 POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION 9 70 2.818e-07 6.127e-06
214 REGULATION OF MEMBRANE PERMEABILITY 9 70 2.818e-07 6.127e-06
215 DNA REPAIR 22 480 3.092e-07 6.691e-06
216 REGULATION OF CYTOPLASMIC TRANSPORT 22 481 3.203e-07 6.9e-06
217 FC EPSILON RECEPTOR SIGNALING PATHWAY 12 142 3.246e-07 6.96e-06
218 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 19 370 3.715e-07 7.93e-06
219 REGULATION OF HOMEOSTATIC PROCESS 21 447 3.878e-07 8.24e-06
220 CELL DEVELOPMENT 42 1426 4.101e-07 8.674e-06
221 NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION 10 96 4.569e-07 9.62e-06
222 POSITIVE REGULATION OF CELL ADHESION 19 376 4.744e-07 9.943e-06
223 SISTER CHROMATID SEGREGATION 13 176 4.976e-07 1.038e-05
224 INTERSPECIES INTERACTION BETWEEN ORGANISMS 26 662 5.023e-07 1.039e-05
225 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 26 662 5.023e-07 1.039e-05
226 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 148 5.082e-07 1.039e-05
227 DEFENSE RESPONSE 38 1231 5.052e-07 1.039e-05
228 PROTEASOMAL PROTEIN CATABOLIC PROCESS 16 271 5.092e-07 1.039e-05
229 RESPONSE TO STEROID HORMONE 22 497 5.564e-07 1.126e-05
230 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 10 98 5.547e-07 1.126e-05
231 REGULATION OF CENTROSOME CYCLE 7 39 5.926e-07 1.194e-05
232 REGULATION OF DEFENSE RESPONSE 28 759 6.261e-07 1.246e-05
233 SPINDLE CHECKPOINT 6 25 6.269e-07 1.246e-05
234 HISTONE PHOSPHORYLATION 6 25 6.269e-07 1.246e-05
235 REGULATION OF MICROTUBULE BASED PROCESS 15 243 6.642e-07 1.315e-05
236 INTRINSIC APOPTOTIC SIGNALING PATHWAY 12 152 6.771e-07 1.335e-05
237 NEURON PROJECTION DEVELOPMENT 23 545 6.979e-07 1.37e-05
238 LYMPHOCYTE COSTIMULATION 9 78 7.224e-07 1.412e-05
239 REGULATION OF GROWTH 25 633 7.615e-07 1.483e-05
240 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 33 1004 7.917e-07 1.535e-05
241 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 18 354 8.755e-07 1.69e-05
242 POSITIVE REGULATION OF NUCLEASE ACTIVITY 5 15 9.286e-07 1.785e-05
243 ESTABLISHMENT OF PROTEIN LOCALIZATION 41 1423 1.014e-06 1.942e-05
244 HIPPO SIGNALING 6 27 1.025e-06 1.955e-05
245 REGULATION OF TRANSPORT 48 1804 1.043e-06 1.982e-05
246 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 10 106 1.153e-06 2.18e-05
247 REGULATION OF DEVELOPMENTAL GROWTH 16 289 1.193e-06 2.238e-05
248 APOPTOTIC SIGNALING PATHWAY 16 289 1.193e-06 2.238e-05
249 MICROTUBULE ORGANIZING CENTER ORGANIZATION 9 84 1.363e-06 2.548e-05
250 LEUKOCYTE MIGRATION 15 259 1.48e-06 2.754e-05
251 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 19 406 1.497e-06 2.774e-05
252 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 13 195 1.589e-06 2.934e-05
253 RESPONSE TO METAL ION 17 333 1.68e-06 3.081e-05
254 CELLULAR RESPONSE TO RADIATION 11 137 1.682e-06 3.081e-05
255 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 10 111 1.763e-06 3.216e-05
256 RHYTHMIC PROCESS 16 298 1.78e-06 3.236e-05
257 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 47 1784 1.821e-06 3.296e-05
258 IMMUNE SYSTEM DEVELOPMENT 23 582 2.132e-06 3.845e-05
259 REGULATION OF SISTER CHROMATID SEGREGATION 8 67 2.326e-06 4.178e-05
260 REGULATION OF CELL CELL ADHESION 18 380 2.399e-06 4.293e-05
261 REGULATION OF CELLULAR COMPONENT BIOGENESIS 27 767 2.441e-06 4.352e-05
262 CELLULAR RESPONSE TO LIGHT STIMULUS 9 91 2.684e-06 4.766e-05
263 RIBOSOME BIOGENESIS 16 308 2.729e-06 4.828e-05
264 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 20 465 2.867e-06 5.053e-05
265 RESPONSE TO IONIZING RADIATION 11 145 2.936e-06 5.135e-05
266 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 11 145 2.936e-06 5.135e-05
267 REGULATION OF NITRIC OXIDE SYNTHASE ACTIVITY 7 49 2.965e-06 5.167e-05
268 MICROTUBULE CYTOSKELETON ORGANIZATION 17 348 3.047e-06 5.29e-05
269 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 10 118 3.08e-06 5.327e-05
270 POSITIVE REGULATION OF CELL ACTIVATION 16 311 3.091e-06 5.327e-05
271 TUBE DEVELOPMENT 22 552 3.125e-06 5.365e-05
272 T CELL RECEPTOR SIGNALING PATHWAY 11 146 3.139e-06 5.37e-05
273 REGULATION OF DNA BINDING 9 93 3.221e-06 5.489e-05
274 DNA REPLICATION 13 208 3.255e-06 5.527e-05
275 MACROMOLECULE CATABOLIC PROCESS 30 926 3.502e-06 5.925e-05
276 REGULATION OF DNA BIOSYNTHETIC PROCESS 9 94 3.522e-06 5.938e-05
277 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 6 33 3.595e-06 6.018e-05
278 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 6 33 3.595e-06 6.018e-05
279 ENERGY RESERVE METABOLIC PROCESS 8 72 4.037e-06 6.733e-05
280 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 13 213 4.225e-06 7.021e-05
281 ESTABLISHMENT OF LOCALIZATION IN CELL 44 1676 4.524e-06 7.491e-05
282 REPRODUCTION 37 1297 4.611e-06 7.608e-05
283 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 74 4.972e-06 8.175e-05
284 TUBE MORPHOGENESIS 16 323 5.011e-06 8.21e-05
285 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 7 53 5.092e-06 8.313e-05
286 REGULATION OF GLYCOGEN METABOLIC PROCESS 6 35 5.157e-06 8.389e-05
287 REGULATION OF MITOCHONDRION ORGANIZATION 13 218 5.444e-06 8.825e-05
288 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 38 1360 5.462e-06 8.825e-05
289 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 17 365 5.748e-06 9.255e-05
290 INNATE IMMUNE RESPONSE 23 619 5.91e-06 9.482e-05
291 CELL PROJECTION ORGANIZATION 29 902 5.97e-06 9.546e-05
292 REGULATION OF CELLULAR RESPONSE TO HEAT 8 76 6.084e-06 9.695e-05
293 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 55 6.558e-06 0.0001038
294 NEGATIVE REGULATION OF DNA REPLICATION 7 55 6.558e-06 0.0001038
295 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 10 131 7.874e-06 0.0001234
296 NEGATIVE REGULATION OF BINDING 10 131 7.874e-06 0.0001234
297 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 10 131 7.874e-06 0.0001234
298 NEGATIVE REGULATION OF PROTEIN BINDING 8 79 8.142e-06 0.0001267
299 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 9 104 8.134e-06 0.0001267
300 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 11 162 8.548e-06 0.0001326
301 CELLULAR RESPONSE TO ABIOTIC STIMULUS 14 263 8.767e-06 0.0001355
302 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 13 228 8.846e-06 0.0001358
303 NUCLEAR CHROMOSOME SEGREGATION 13 228 8.846e-06 0.0001358
304 CELLULAR GLUCAN METABOLIC PROCESS 7 58 9.402e-06 0.0001434
305 GLUCAN METABOLIC PROCESS 7 58 9.402e-06 0.0001434
306 REGULATION OF NUCLEASE ACTIVITY 5 23 9.562e-06 0.0001454
307 CELLULAR MACROMOLECULE LOCALIZATION 35 1234 9.733e-06 0.0001475
308 REGULATION OF FIBROBLAST PROLIFERATION 8 81 9.818e-06 0.0001483
309 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 6 39 9.927e-06 0.0001495
310 NEURON DEVELOPMENT 24 687 1.034e-05 0.0001552
311 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 7 59 1.055e-05 0.0001579
312 NEGATIVE REGULATION OF CELL PROLIFERATION 23 643 1.093e-05 0.000163
313 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 11 167 1.141e-05 0.000169
314 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 1.141e-05 0.000169
315 NEGATIVE REGULATION OF CELL COMMUNICATION 34 1192 1.175e-05 0.0001736
316 REGULATION OF MONOOXYGENASE ACTIVITY 7 60 1.181e-05 0.000174
317 RESPONSE TO BIOTIC STIMULUS 28 886 1.198e-05 0.0001759
318 POSITIVE REGULATION OF TRANSPORT 29 936 1.203e-05 0.000176
319 POSITIVE REGULATION OF MAPK CASCADE 19 470 1.229e-05 0.0001793
320 CHROMOSOME SEGREGATION 14 272 1.282e-05 0.0001864
321 RESPONSE TO OXYGEN LEVELS 15 311 1.362e-05 0.0001962
322 CELLULAR RESPONSE TO CYTOKINE STIMULUS 22 606 1.361e-05 0.0001962
323 RESPONSE TO DRUG 18 431 1.354e-05 0.0001962
324 SISTER CHROMATID COHESION 9 111 1.383e-05 0.0001987
325 POSITIVE REGULATION OF GROWTH 13 238 1.4e-05 0.0002004
326 EPHRIN RECEPTOR SIGNALING PATHWAY 8 85 1.405e-05 0.0002006
327 EPITHELIUM DEVELOPMENT 29 945 1.438e-05 0.0002046
328 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 11 172 1.506e-05 0.0002136
329 POSITIVE REGULATION OF DNA REPLICATION 8 86 1.532e-05 0.0002167
330 POSITIVE REGULATION OF DNA BINDING 6 42 1.545e-05 0.0002179
331 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 437 1.63e-05 0.0002291
332 RAS PROTEIN SIGNAL TRANSDUCTION 10 143 1.703e-05 0.0002387
333 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 4 13 1.765e-05 0.0002466
334 HOMEOSTASIS OF NUMBER OF CELLS 11 175 1.771e-05 0.0002467
335 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 6 43 1.777e-05 0.0002468
336 ESTABLISHMENT OF CELL POLARITY 8 88 1.816e-05 0.0002504
337 REGULATION OF CYTOKINESIS 7 64 1.819e-05 0.0002504
338 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 8 88 1.816e-05 0.0002504
339 RESPONSE TO ACID CHEMICAL 15 319 1.836e-05 0.0002519
340 NEGATIVE REGULATION OF MAPK CASCADE 10 145 1.922e-05 0.0002623
341 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 10 145 1.922e-05 0.0002623
342 IMMUNE EFFECTOR PROCESS 19 486 1.956e-05 0.0002661
343 MITOCHONDRIAL TRANSPORT 11 177 1.969e-05 0.0002671
344 REGULATION OF OXIDOREDUCTASE ACTIVITY 8 90 2.142e-05 0.0002897
345 PROTEIN CATABOLIC PROCESS 21 579 2.179e-05 0.0002938
346 REPRODUCTIVE SYSTEM DEVELOPMENT 17 408 2.428e-05 0.0003262
347 MACROMOLECULAR COMPLEX ASSEMBLY 37 1398 2.433e-05 0.0003262
348 CENTRAL NERVOUS SYSTEM DEVELOPMENT 27 872 2.476e-05 0.0003311
349 POSITIVE REGULATION OF CELL DIFFERENTIATION 26 823 2.514e-05 0.0003351
350 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 12 216 2.538e-05 0.0003375
351 NEGATIVE REGULATION OF PROTEOLYSIS 15 329 2.628e-05 0.0003484
352 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 5 28 2.649e-05 0.0003492
353 PEPTIDYL THREONINE MODIFICATION 6 46 2.643e-05 0.0003492
354 POSITIVE REGULATION OF TELOMERE MAINTENANCE 6 47 2.997e-05 0.0003939
355 REGULATION OF CELL CYCLE CHECKPOINT 5 29 3.168e-05 0.0004129
356 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 29 3.168e-05 0.0004129
357 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 29 3.168e-05 0.0004129
358 FC GAMMA RECEPTOR SIGNALING PATHWAY 8 95 3.177e-05 0.000413
359 CELLULAR RESPONSE TO NITRIC OXIDE 4 15 3.302e-05 0.000428
360 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 15 337 3.466e-05 0.000448
361 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 10 156 3.611e-05 0.0004654
362 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 21 602 3.845e-05 0.0004942
363 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 513 4.085e-05 0.0005236
364 POSITIVE REGULATION OF PROTEIN BINDING 7 73 4.323e-05 0.0005481
365 LYMPHOCYTE HOMEOSTASIS 6 50 4.294e-05 0.0005481
366 REGULATION OF ORGAN GROWTH 7 73 4.323e-05 0.0005481
367 CELLULAR COMPONENT DISASSEMBLY 19 515 4.305e-05 0.0005481
368 RNA STABILIZATION 5 31 4.438e-05 0.0005611
369 RESPONSE TO WOUNDING 20 563 4.588e-05 0.000577
370 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 9 129 4.588e-05 0.000577
371 REGULATION OF HOMOTYPIC CELL CELL ADHESION 14 307 4.871e-05 0.000611
372 MICROTUBULE BASED PROCESS 19 522 5.157e-05 0.0006451
373 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 5 32 5.204e-05 0.0006492
374 REGULATION OF CELL GROWTH 16 391 5.228e-05 0.0006504
375 RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 10 163 5.244e-05 0.0006507
376 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 11 197 5.27e-05 0.0006522
377 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 12 233 5.317e-05 0.0006563
378 REGULATION OF PEPTIDASE ACTIVITY 16 392 5.389e-05 0.0006633
379 POSITIVE REGULATION OF CELL DIVISION 9 132 5.493e-05 0.0006744
380 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 103 5.688e-05 0.0006965
381 NEGATIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 6 53 6.007e-05 0.0007336
382 POSITIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 5 33 6.07e-05 0.0007374
383 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 5 33 6.07e-05 0.0007374
384 REGULATION OF INTERLEUKIN 6 PRODUCTION 8 104 6.095e-05 0.0007385
385 REGULATION OF CELL ACTIVATION 18 484 6.19e-05 0.0007462
386 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 9 134 6.177e-05 0.0007462
387 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 17 440 6.228e-05 0.0007469
388 TISSUE DEVELOPMENT 38 1518 6.225e-05 0.0007469
389 NUCLEAR TRANSPORT 15 355 6.261e-05 0.0007489
390 REGULATION OF ERK1 AND ERK2 CASCADE 12 238 6.522e-05 0.0007782
391 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 26 873 6.714e-05 0.000799
392 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 10 168 6.765e-05 0.0008009
393 REGULATION OF AXONOGENESIS 10 168 6.765e-05 0.0008009
394 MORPHOGENESIS OF AN EPITHELIUM 16 400 6.837e-05 0.0008059
395 NEURON DIFFERENTIATION 26 874 6.841e-05 0.0008059
396 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 27 926 6.912e-05 0.0008122
397 T CELL HOMEOSTASIS 5 34 7.042e-05 0.0008232
398 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 5 34 7.042e-05 0.0008232
399 RESPONSE TO PLATELET DERIVED GROWTH FACTOR 4 18 7.18e-05 0.0008352
400 REGULATION OF UBIQUITIN PROTEIN LIGASE ACTIVITY 4 18 7.18e-05 0.0008352
401 ACTIVATION OF PROTEIN KINASE ACTIVITY 13 279 7.286e-05 0.0008455
402 CIRCADIAN RHYTHM 9 137 7.336e-05 0.000847
403 ACTIVATION OF MAPK ACTIVITY 9 137 7.336e-05 0.000847
404 RESPONSE TO RETINOIC ACID 8 107 7.461e-05 0.0008593
405 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 9 138 7.761e-05 0.0008894
406 PLACENTA DEVELOPMENT 9 138 7.761e-05 0.0008894
407 POLYSACCHARIDE METABOLIC PROCESS 7 80 7.807e-05 0.0008926
408 POSITIVE REGULATION OF CELL CELL ADHESION 12 243 7.956e-05 0.0009074
409 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 13 282 8.117e-05 0.0009226
410 NEURON APOPTOTIC PROCESS 5 35 8.129e-05 0.0009226
411 REGULATION OF CELL SIZE 10 172 8.236e-05 0.0009325
412 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 109 8.506e-05 0.0009606
413 REGULATION OF CELL SUBSTRATE ADHESION 10 173 8.644e-05 0.0009739
414 DENDRITIC SPINE DEVELOPMENT 4 19 9.003e-05 0.001009
415 CELLULAR RESPONSE TO REACTIVE NITROGEN SPECIES 4 19 9.003e-05 0.001009
416 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 9 141 9.161e-05 0.001023
417 CARDIOVASCULAR SYSTEM DEVELOPMENT 24 788 9.193e-05 0.001023
418 CIRCULATORY SYSTEM DEVELOPMENT 24 788 9.193e-05 0.001023
419 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 740 9.576e-05 0.001063
420 CELLULAR RESPONSE TO LIPID 17 457 9.881e-05 0.001092
421 NIK NF KAPPAB SIGNALING 7 83 9.875e-05 0.001092
422 CELLULAR RESPONSE TO OXYGEN LEVELS 9 143 0.0001021 0.001126
423 REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 6 59 0.0001105 0.001216
424 PROTEIN ADP RIBOSYLATION 4 20 0.0001114 0.001222
425 REGULATION OF NEURON DEATH 12 252 0.0001123 0.001229
426 LEUKOCYTE DIFFERENTIATION 13 292 0.0001151 0.001257
427 PROTEIN LOCALIZATION TO ORGANELLE 19 556 0.0001182 0.001288
428 RESPONSE TO ESTRADIOL 9 146 0.0001196 0.001301
429 NEGATIVE REGULATION OF CELL DIVISION 6 60 0.0001215 0.001315
430 LEUKOCYTE HOMEOSTASIS 6 60 0.0001215 0.001315
431 PROTEIN SUMOYLATION 8 115 0.0001239 0.001338
432 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 11 218 0.0001303 0.001403
433 B CELL HOMEOSTASIS 4 21 0.0001362 0.001454
434 REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 4 21 0.0001362 0.001454
435 NEGATIVE REGULATION OF ORGAN GROWTH 4 21 0.0001362 0.001454
436 RESPONSE TO NITRIC OXIDE 4 21 0.0001362 0.001454
437 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 15 381 0.0001371 0.00146
438 HEAD DEVELOPMENT 22 709 0.0001395 0.001482
439 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 11 220 0.0001412 0.001496
440 MYELOID CELL HOMEOSTASIS 7 88 0.000143 0.001512
441 PROTEIN COMPLEX SUBUNIT ORGANIZATION 37 1527 0.0001523 0.001607
442 MEIOTIC CELL CYCLE 10 186 0.0001571 0.00165
443 RESPONSE TO GROWTH FACTOR 17 475 0.0001569 0.00165
444 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 7 90 0.0001646 0.001721
445 REGULATION OF CELL MATRIX ADHESION 7 90 0.0001646 0.001721
446 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 13 303 0.0001659 0.001731
447 AGING 12 264 0.0001734 0.001805
448 MYELOID CELL DIFFERENTIATION 10 189 0.000179 0.001859
449 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 27 983 0.0001843 0.00191
450 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 9 156 0.0001975 0.002042
451 WNT SIGNALING PATHWAY 14 351 2e-04 0.002063
452 PROTEOLYSIS 31 1208 0.0002039 0.002099
453 INTRACELLULAR PROTEIN TRANSPORT 23 781 0.0002105 0.002162
454 RESPONSE TO PURINE CONTAINING COMPOUND 9 158 0.0002173 0.002227
455 REGULATION OF TELOMERASE ACTIVITY 5 43 0.0002216 0.002266
456 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 6 67 0.0002246 0.002292
457 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 8 126 0.0002331 0.002373
458 NEURON PROJECTION MORPHOGENESIS 15 402 0.0002449 0.002488
459 EMBRYO DEVELOPMENT 25 894 0.0002458 0.002491
460 REGULATION OF INTERFERON BETA PRODUCTION 5 44 0.0002474 0.002503
461 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 11 236 0.0002597 0.002621
462 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 162 0.0002618 0.002637
463 MITOTIC SPINDLE ORGANIZATION 6 69 0.0002641 0.002654
464 CELLULAR COMPONENT MORPHOGENESIS 25 900 0.0002718 0.002725
465 CELL DIFFERENTIATION INVOLVED IN EMBRYONIC PLACENTA DEVELOPMENT 4 25 0.0002765 0.002749
466 PROTEIN LOCALIZATION TO CHROMOSOME 5 45 0.0002755 0.002749
467 POSITIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 4 25 0.0002765 0.002749
468 POSITIVE REGULATION OF CHROMOSOME SEGREGATION 4 25 0.0002765 0.002749
469 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 7 98 0.0002794 0.002772
470 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 7 99 0.0002974 0.002944
471 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 23 801 0.0003017 0.00298
472 RESPONSE TO COCAINE 5 46 0.0003058 0.003008
473 NEGATIVE REGULATION OF NUCLEAR DIVISION 5 46 0.0003058 0.003008
474 REGULATION OF MITOTIC SPINDLE CHECKPOINT 3 11 0.0003243 0.00317
475 FEMALE MEIOTIC DIVISION 4 26 0.0003234 0.00317
476 REGULATION OF MITOTIC CELL CYCLE SPINDLE ASSEMBLY CHECKPOINT 3 11 0.0003243 0.00317
477 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 27 1021 0.0003361 0.003272
478 REGULATION OF EXTENT OF CELL GROWTH 7 101 0.0003362 0.003272
479 NEURON DEATH 5 47 0.0003387 0.00329
480 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 135 0.0003722 0.003608
481 RESPONSE TO VIRUS 11 247 0.0003828 0.003703
482 HEART DEVELOPMENT 16 466 0.0003867 0.003733
483 REGULATION OF PROTEIN COMPLEX ASSEMBLY 14 375 0.0003907 0.003756
484 NEGATIVE REGULATION OF NEURON DEATH 9 171 0.0003901 0.003756
485 RESPONSE TO CAMP 7 104 0.0004019 0.003855
486 RIBOSOMAL LARGE SUBUNIT BIOGENESIS 5 49 0.0004123 0.003947
487 REGULATION OF DNA REPAIR 6 75 0.000416 0.003975
488 STRIATED MUSCLE CELL DIFFERENTIATION 9 173 0.0004246 0.004049
489 X3 UTR MEDIATED MRNA STABILIZATION 3 12 0.0004283 0.004067
490 REPLICATIVE SENESCENCE 3 12 0.0004283 0.004067
491 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 0.0004341 0.004081
492 POSITIVE REGULATION OF TELOMERASE ACTIVITY 4 28 0.0004341 0.004081
493 REGULATION OF INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY 4 28 0.0004341 0.004081
494 REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 4 28 0.0004341 0.004081
495 GENERATION OF PRECURSOR METABOLITES AND ENERGY 12 292 0.0004342 0.004081
496 POSITIVE REGULATION OF CELL DEVELOPMENT 16 472 0.0004446 0.004171
497 RESPONSE TO ORGANOPHOSPHORUS 8 139 0.0004527 0.004235
498 RESPONSE TO GAMMA RADIATION 5 50 0.0004533 0.004235
499 REGULATION OF CELLULAR COMPONENT SIZE 13 337 0.0004617 0.004288
500 CELLULAR RESPONSE TO ACID CHEMICAL 9 175 0.0004617 0.004288
501 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 9 175 0.0004617 0.004288
502 RESPONSE TO CORTICOSTEROID 9 176 0.0004812 0.00446
503 RESPONSE TO AMMONIUM ION 5 51 0.0004974 0.004601
504 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 4 29 0.0004985 0.004602
505 DNA RECOMBINATION 10 215 0.0005002 0.004609
506 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 12 297 0.0005051 0.004644
507 REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION 9 178 0.0005223 0.004793
508 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 10 217 0.0005377 0.004925
509 DENDRITE DEVELOPMENT 6 79 0.0005502 0.005012
510 POSITIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 3 13 0.0005515 0.005012
511 REGULATION OF IRE1 MEDIATED UNFOLDED PROTEIN RESPONSE 3 13 0.0005515 0.005012
512 POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 13 0.0005515 0.005012
513 PROTEIN UBIQUITINATION 19 629 0.0005532 0.005017
514 RESPONSE TO ESTROGEN 10 218 0.0005572 0.005044
515 ESTABLISHMENT OR MAINTENANCE OF EPITHELIAL CELL APICAL BASAL POLARITY 4 30 0.0005694 0.005115
516 POSITIVE REGULATION OF INTERFERON BETA PRODUCTION 4 30 0.0005694 0.005115
517 REGULATION OF VASCULAR PERMEABILITY 4 30 0.0005694 0.005115
518 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 4 30 0.0005694 0.005115
519 CELLULAR CARBOHYDRATE METABOLIC PROCESS 8 144 0.0005726 0.005133
520 COVALENT CHROMATIN MODIFICATION 13 345 0.0005753 0.005148
521 INSULIN RECEPTOR SIGNALING PATHWAY 6 80 0.0005885 0.005255
522 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 53 0.000595 0.005304
523 RESPONSE TO KETONE 9 182 0.000613 0.005454
524 NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION 10 221 0.0006196 0.005502
525 REGULATION OF PROTEIN IMPORT 9 183 0.0006376 0.005651
526 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 5 54 0.0006489 0.00574
527 GLAND DEVELOPMENT 14 395 0.0006525 0.005761
528 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 25 957 0.0006686 0.005892
529 JNK CASCADE 6 82 0.0006712 0.005904
530 POSITIVE REGULATION OF CELL GROWTH 8 148 0.000686 0.006022
531 REGULATION OF SPINDLE CHECKPOINT 3 14 0.0006952 0.006069
532 REGULATION OF PROTEIN LOCALIZATION TO CHROMOSOME TELOMERIC REGION 3 14 0.0006952 0.006069
533 POST EMBRYONIC ORGAN DEVELOPMENT 3 14 0.0006952 0.006069
534 ACTIN CYTOSKELETON REORGANIZATION 5 55 0.0007064 0.006143
535 EXECUTION PHASE OF APOPTOSIS 5 55 0.0007064 0.006143
536 REGULATION OF ERBB SIGNALING PATHWAY 6 83 0.0007158 0.006202
537 EMBRYONIC PLACENTA DEVELOPMENT 6 83 0.0007158 0.006202
538 PATTERNING OF BLOOD VESSELS 4 32 0.0007322 0.006309
539 REGULATION OF CENTROSOME DUPLICATION 4 32 0.0007322 0.006309
540 CENTROSOME DUPLICATION 4 32 0.0007322 0.006309
541 REGULATION OF WNT SIGNALING PATHWAY 12 310 0.0007363 0.006321
542 RESPONSE TO INTERLEUKIN 1 7 115 0.0007354 0.006321
543 PROTEIN COMPLEX BIOGENESIS 28 1132 0.0007456 0.006377
544 PROTEIN COMPLEX ASSEMBLY 28 1132 0.0007456 0.006377
545 IN UTERO EMBRYONIC DEVELOPMENT 12 311 0.0007572 0.006465
546 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 6 84 0.0007627 0.006499
547 PEPTIDYL LYSINE MODIFICATION 12 312 0.0007787 0.006624
548 ACTIN FILAMENT BASED PROCESS 15 450 0.0007919 0.006724
549 TOLL LIKE RECEPTOR SIGNALING PATHWAY 6 85 0.0008119 0.006881
550 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 8 152 0.0008168 0.006885
551 MEIOTIC CELL CYCLE PROCESS 8 152 0.0008168 0.006885
552 REGULATION OF GENE EXPRESSION EPIGENETIC 10 229 0.0008145 0.006885
553 REGULATION OF PROTEIN EXPORT FROM NUCLEUS 4 33 0.0008248 0.006928
554 REGULATION OF BONE RESORPTION 4 33 0.0008248 0.006928
555 CIRCADIAN REGULATION OF GENE EXPRESSION 5 57 0.0008326 0.006961
556 ENDOTHELIAL CELL MIGRATION 5 57 0.0008326 0.006961
557 PHAGOCYTOSIS 9 190 0.0008333 0.006961
558 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 8 153 0.0008524 0.007108
559 T CELL APOPTOTIC PROCESS 3 15 0.0008607 0.007165
560 REGULATION OF CELL MORPHOGENESIS 17 552 0.0008709 0.007236
561 REGULATION OF NEURON APOPTOTIC PROCESS 9 192 0.0008974 0.007443
562 ER NUCLEUS SIGNALING PATHWAY 4 34 0.0009254 0.007662
563 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 9 193 0.0009309 0.007694
564 PHOSPHOLIPID METABOLIC PROCESS 13 364 0.0009427 0.007774
565 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 7 120 0.0009457 0.007774
566 REGULATION OF DENDRITE DEVELOPMENT 7 120 0.0009457 0.007774
567 SINGLE ORGANISM CELL ADHESION 15 459 0.0009666 0.007932
568 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 5 59 0.0009749 0.007973
569 MEIOSIS I 6 88 0.0009743 0.007973
570 PHOSPHOLIPID BIOSYNTHETIC PROCESS 10 235 0.0009917 0.008077
571 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 0.0009929 0.008077
572 REGULATION OF B CELL ACTIVATION 7 121 0.0009929 0.008077
573 B CELL DIFFERENTIATION 6 89 0.001034 0.00837
574 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 6 89 0.001034 0.00837
575 RESPONSE TO MINERALOCORTICOID 4 35 0.001034 0.00837
576 CELLULAR RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 7 122 0.001042 0.008418
577 POSITIVE REGULATION OF TELOMERE CAPPING 3 16 0.001049 0.008447
578 DNA LIGATION 3 16 0.001049 0.008447
579 MUSCLE CELL DIFFERENTIATION 10 237 0.001057 0.008497
580 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 9 197 0.001075 0.008627
581 REGULATION OF JNK CASCADE 8 159 0.001093 0.008757
582 REGULATION OF PROTEIN TYROSINE KINASE ACTIVITY 5 61 0.001135 0.009071
583 POSITIVE REGULATION OF AXON EXTENSION 4 36 0.001152 0.009162
584 POSITIVE REGULATION OF ERBB SIGNALING PATHWAY 4 36 0.001152 0.009162
585 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 4 36 0.001152 0.009162
586 MITOTIC SISTER CHROMATID SEGREGATION 6 91 0.001161 0.009215
587 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 9 200 0.001195 0.009473
588 RESPONSE TO TOXIC SUBSTANCE 10 241 0.001199 0.00949
589 WOUND HEALING 15 470 0.001223 0.009631
590 REGULATION OF MULTI ORGANISM PROCESS 15 470 0.001223 0.009631
591 REGULATION OF TISSUE REMODELING 5 62 0.001221 0.009631
592 REGULATION OF ORGAN MORPHOGENESIS 10 242 0.001237 0.009723
593 RESPONSE TO ANGIOTENSIN 3 17 0.001262 0.00987
594 NEGATIVE REGULATION OF CELL AGING 3 17 0.001262 0.00987
595 NEGATIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 3 17 0.001262 0.00987
596 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 4 37 0.001279 0.009949
597 ESTABLISHMENT OR MAINTENANCE OF APICAL BASAL CELL POLARITY 4 37 0.001279 0.009949
598 ESTABLISHMENT OR MAINTENANCE OF BIPOLAR CELL POLARITY 4 37 0.001279 0.009949
599 CELLULAR RESPONSE TO BIOTIC STIMULUS 8 163 0.001282 0.00996
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOTIDE BINDING 110 1860 3.158e-46 2.933e-43
2 KINASE ACTIVITY 74 842 3.955e-41 1.805e-38
3 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 79 992 5.83e-41 1.805e-38
4 PROTEIN KINASE ACTIVITY 65 640 9.906e-40 2.301e-37
5 PROTEIN SERINE THREONINE KINASE ACTIVITY 53 445 9.671e-36 1.797e-33
6 ADENYL NUCLEOTIDE BINDING 83 1514 3.442e-31 5.329e-29
7 ENZYME BINDING 85 1737 1.801e-28 2.39e-26
8 KINASE BINDING 48 606 2.492e-24 2.894e-22
9 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 22 178 1.371e-15 1.416e-13
10 GUANYL NUCLEOTIDE BINDING 29 390 3.006e-14 2.793e-12
11 HEAT SHOCK PROTEIN BINDING 14 89 8.013e-12 6.767e-10
12 GTPASE ACTIVITY 21 246 9.288e-12 7.191e-10
13 PHOSPHATASE ACTIVITY 22 275 1.06e-11 7.574e-10
14 PROTEIN TYROSINE PHOSPHATASE ACTIVITY 14 103 6.154e-11 4.084e-09
15 IDENTICAL PROTEIN BINDING 45 1209 1.134e-10 7.02e-09
16 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 9 34 3.406e-10 1.978e-08
17 RNA BINDING 51 1598 1.226e-09 6.699e-08
18 POLY A RNA BINDING 42 1170 1.547e-09 7.985e-08
19 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 34 820 1.927e-09 9.424e-08
20 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 12 92 2.392e-09 1.111e-07
21 PHOSPHORIC ESTER HYDROLASE ACTIVITY 22 368 2.774e-09 1.227e-07
22 TAU PROTEIN KINASE ACTIVITY 6 12 3.765e-09 1.59e-07
23 PROTEIN TYROSINE KINASE ACTIVITY 15 176 9.531e-09 3.85e-07
24 HISTONE DEACETYLASE BINDING 12 105 1.11e-08 4.123e-07
25 PROTEIN DOMAIN SPECIFIC BINDING 28 624 1.086e-08 4.123e-07
26 PROTEIN PHOSPHATASE BINDING 12 120 5.053e-08 1.805e-06
27 MACROMOLECULAR COMPLEX BINDING 43 1399 8.979e-08 3.09e-06
28 HISTONE KINASE ACTIVITY 6 19 1.025e-07 3.4e-06
29 NON MEMBRANE SPANNING PROTEIN TYROSINE KINASE ACTIVITY 8 46 1.175e-07 3.765e-06
30 PROTEIN COMPLEX BINDING 33 935 1.59e-07 4.925e-06
31 MAGNESIUM ION BINDING 14 199 3.271e-07 9.802e-06
32 RECEPTOR SIGNALING PROTEIN ACTIVITY 13 172 3.821e-07 1.109e-05
33 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 7 39 5.926e-07 1.668e-05
34 PHOSPHATASE BINDING 12 162 1.335e-06 3.648e-05
35 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 8 64 1.632e-06 4.331e-05
36 KINASE REGULATOR ACTIVITY 12 186 5.635e-06 0.0001454
37 DOUBLE STRANDED RNA BINDING 7 64 1.819e-05 0.0004567
38 PROTEIN DIMERIZATION ACTIVITY 32 1149 3.463e-05 0.0008466
39 UBIQUITIN LIKE PROTEIN LIGASE BINDING 13 264 4.144e-05 0.0009872
40 PROTEIN HOMODIMERIZATION ACTIVITY 23 722 6.626e-05 0.001539
41 HYDROLASE ACTIVITY ACTING ON ESTER BONDS 23 739 9.386e-05 0.002127
42 ION CHANNEL BINDING 8 111 9.669e-05 0.002139
43 PROTEIN HETERODIMERIZATION ACTIVITY 17 468 0.0001315 0.00284
44 KINASE ACTIVATOR ACTIVITY 6 62 0.000146 0.003083
45 PROTEIN C TERMINUS BINDING 10 186 0.0001571 0.003244
46 TRANSCRIPTION FACTOR BINDING 18 524 0.0001675 0.003311
47 RECEPTOR BINDING 36 1476 0.000166 0.003311
48 EPHRIN RECEPTOR BINDING 4 24 0.0002346 0.00454
49 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE REGULATOR ACTIVITY 4 28 0.0004341 0.00823
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEOLUS 41 848 2.523e-13 1.473e-10
2 NUCLEAR CHROMOSOME 31 523 1.585e-12 4.628e-10
3 CHROMOSOME 39 880 1.484e-11 2.167e-09
4 PERINUCLEAR REGION OF CYTOPLASM 33 642 1.369e-11 2.167e-09
5 CHROMOSOMAL REGION 22 330 3.613e-10 4.221e-08
6 MICROTUBULE ORGANIZING CENTER 29 623 2.555e-09 2.487e-07
7 MICROTUBULE CYTOSKELETON 39 1068 4.03e-09 3.362e-07
8 CENTROSOME 24 487 2.24e-08 1.635e-06
9 CONDENSED CHROMOSOME 15 195 3.794e-08 2.462e-06
10 CYTOPLASMIC SIDE OF MEMBRANE 13 170 3.339e-07 1.95e-05
11 CYTOSKELETON 52 1967 4.066e-07 2.159e-05
12 CYTOSKELETAL PART 42 1436 4.936e-07 2.402e-05
13 RUFFLE MEMBRANE 9 80 8.983e-07 4.035e-05
14 CELL SUBSTRATE JUNCTION 19 398 1.114e-06 4.648e-05
15 CHROMOSOME TELOMERIC REGION 12 162 1.335e-06 5.198e-05
16 CONDENSED NUCLEAR CHROMOSOME 9 85 1.508e-06 5.504e-05
17 CONDENSED NUCLEAR CHROMOSOME CENTROMERIC REGION 5 18 2.567e-06 8.817e-05
18 SPINDLE POLE 10 126 5.564e-06 0.0001578
19 NUCLEOPLASM PART 25 708 5.577e-06 0.0001578
20 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 9 98 4.982e-06 0.0001578
21 SPINDLE 15 289 5.676e-06 0.0001578
22 CONDENSED CHROMOSOME CENTROMERIC REGION 9 102 6.934e-06 0.0001841
23 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 10 136 1.097e-05 0.0002785
24 CELL LEADING EDGE 16 350 1.369e-05 0.0003331
25 CELL JUNCTION 33 1151 1.441e-05 0.0003367
26 CHROMOSOME CENTROMERIC REGION 11 174 1.678e-05 0.000377
27 ANCHORING JUNCTION 19 489 2.129e-05 0.0004605
28 KINETOCHORE 9 120 2.589e-05 0.0005399
29 RUFFLE 10 156 3.611e-05 0.0007272
30 SIDE OF MEMBRANE 17 428 4.426e-05 0.0008616
31 NUCLEAR CHROMOSOME TELOMERIC REGION 9 132 5.493e-05 0.001003
32 MIDBODY 9 132 5.493e-05 0.001003
33 PIGMENT GRANULE 8 103 5.688e-05 0.001007
34 LEADING EDGE MEMBRANE 9 134 6.177e-05 0.001061
35 CHROMATIN 17 441 6.404e-05 0.001069
36 SPINDLE MICROTUBULE 6 58 0.0001004 0.001628
37 TRANSFERASE COMPLEX 22 703 0.0001236 0.001951
38 NUCLEAR TRANSCRIPTIONAL REPRESSOR COMPLEX 4 22 0.0001648 0.002533
39 RNA POLYMERASE COMPLEX 8 122 0.0001867 0.002796
40 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 11 237 0.0002693 0.003932
41 MEMBRANE REGION 29 1134 0.0003499 0.004984
42 SPINDLE MIDZONE 4 27 0.0003759 0.005226
43 NUCLEAR CHROMATIN 12 291 0.0004211 0.005636
44 CATALYTIC COMPLEX 27 1038 0.0004342 0.005636
45 CONDENSED CHROMOSOME OUTER KINETOCHORE 3 12 0.0004283 0.005636
46 EXTRINSIC COMPONENT OF MEMBRANE 11 252 0.0004532 0.005707
47 RIBONUCLEOPROTEIN COMPLEX 21 721 0.0004593 0.005707
48 CAJAL BODY 5 52 0.0005445 0.006515
49 SIN3 COMPLEX 3 13 0.0005515 0.006515
50 MITOCHONDRION 37 1633 0.0005578 0.006515
51 NUCLEAR BODY 13 349 0.0006404 0.007333
52 MITOTIC SPINDLE 5 55 0.0007064 0.007783
53 TRANSCRIPTION FACTOR TFTC COMPLEX 3 14 0.0006952 0.007783
54 PRONUCLEUS 3 15 0.0008607 0.009309

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04110_Cell_cycle 34 128 2.604e-35 4.687e-33
2 hsa04114_Oocyte_meiosis 20 114 2.538e-17 2.284e-15
3 hsa04914_Progesterone.mediated_oocyte_maturation 17 87 9.885e-16 5.931e-14
4 hsa04722_Neurotrophin_signaling_pathway 19 127 3.509e-15 1.579e-13
5 hsa04012_ErbB_signaling_pathway 15 87 3.49e-13 1.256e-11
6 hsa04910_Insulin_signaling_pathway 17 138 2.675e-12 8.026e-11
7 hsa04151_PI3K_AKT_signaling_pathway 24 351 3.255e-11 8.371e-10
8 hsa04360_Axon_guidance 15 130 1.369e-10 3.081e-09
9 hsa04810_Regulation_of_actin_cytoskeleton 18 214 3.774e-10 7.548e-09
10 hsa04510_Focal_adhesion 17 200 1.001e-09 1.802e-08
11 hsa04660_T_cell_receptor_signaling_pathway 13 108 1.405e-09 2.299e-08
12 hsa04115_p53_signaling_pathway 10 69 1.869e-08 2.803e-07
13 hsa04520_Adherens_junction 10 73 3.263e-08 4.519e-07
14 hsa04370_VEGF_signaling_pathway 10 76 4.846e-08 6.231e-07
15 hsa04010_MAPK_signaling_pathway 17 268 7.966e-08 9.559e-07
16 hsa04390_Hippo_signaling_pathway 13 154 1.054e-07 1.186e-06
17 hsa04150_mTOR_signaling_pathway 8 52 3.17e-07 3.357e-06
18 hsa03008_Ribosome_biogenesis_in_eukaryotes 9 81 9.993e-07 9.993e-06
19 hsa04662_B_cell_receptor_signaling_pathway 8 75 5.505e-06 5.215e-05
20 hsa04620_Toll.like_receptor_signaling_pathway 9 102 6.934e-06 6.241e-05
21 hsa04530_Tight_junction 10 133 9.007e-06 7.72e-05
22 hsa04014_Ras_signaling_pathway 13 236 1.28e-05 0.0001047
23 hsa04666_Fc_gamma_R.mediated_phagocytosis 8 95 3.177e-05 0.0002487
24 hsa04062_Chemokine_signaling_pathway 11 189 3.611e-05 0.0002709
25 hsa04664_Fc_epsilon_RI_signaling_pathway 7 79 7.203e-05 0.0005186
26 hsa04720_Long.term_potentiation 6 70 0.0002858 0.001979
27 hsa04650_Natural_killer_cell_mediated_cytotoxicity 8 136 0.0003911 0.002608
28 hsa03020_RNA_polymerase 4 29 0.0004985 0.003205
29 hsa03410_Base_excision_repair 4 34 0.0009254 0.005744
30 hsa04210_Apoptosis 6 89 0.001034 0.006202
31 hsa04540_Gap_junction 6 90 0.001096 0.006362
32 hsa04912_GnRH_signaling_pathway 6 101 0.001983 0.01116
33 hsa04623_Cytosolic_DNA.sensing_pathway 4 56 0.005876 0.03205
34 hsa04141_Protein_processing_in_endoplasmic_reticulum 7 168 0.00625 0.03309
35 hsa04621_NOD.like_receptor_signaling_pathway 4 59 0.007066 0.03634
36 hsa04622_RIG.I.like_receptor_signaling_pathway 4 71 0.01339 0.06693
37 hsa04144_Endocytosis 7 203 0.01652 0.08036
38 hsa04670_Leukocyte_transendothelial_migration 5 117 0.01791 0.08463
39 hsa04070_Phosphatidylinositol_signaling_system 4 78 0.01834 0.08463
40 hsa03050_Proteasome 3 45 0.02022 0.08876
41 hsa03420_Nucleotide_excision_repair 3 45 0.02022 0.08876
42 hsa04330_Notch_signaling_pathway 3 47 0.02267 0.09717
43 hsa04380_Osteoclast_differentiation 5 128 0.02527 0.1058
44 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.03434 0.1405
45 hsa00562_Inositol_phosphate_metabolism 3 57 0.03728 0.1491
46 hsa00240_Pyrimidine_metabolism 4 99 0.03935 0.154
47 hsa04320_Dorso.ventral_axis_formation 2 25 0.04093 0.1567
48 hsa04916_Melanogenesis 4 101 0.04185 0.157
49 hsa04310_Wnt_signaling_pathway 5 151 0.04628 0.17
50 hsa04630_Jak.STAT_signaling_pathway 5 155 0.05074 0.1827
51 hsa00020_Citrate_cycle_.TCA_cycle. 2 30 0.05692 0.2009
52 hsa00230_Purine_metabolism 5 162 0.05914 0.2047
53 hsa03320_PPAR_signaling_pathway 3 70 0.06185 0.2101
54 hsa00051_Fructose_and_mannose_metabolism 2 36 0.07844 0.2521
55 hsa03030_DNA_replication 2 36 0.07844 0.2521
56 hsa04612_Antigen_processing_and_presentation 3 78 0.07988 0.2523
57 hsa04512_ECM.receptor_interaction 3 85 0.0973 0.2987
58 hsa00350_Tyrosine_metabolism 2 41 0.09797 0.2987
59 hsa04514_Cell_adhesion_molecules_.CAMs. 4 136 0.09956 0.2987
60 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.102 0.3011
61 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.1103 0.3202
62 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 2 48 0.1273 0.3636
63 hsa03013_RNA_transport 4 152 0.134 0.3654
64 hsa04145_Phagosome 4 156 0.1432 0.3848
65 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.189 0.4932
66 hsa00010_Glycolysis_._Gluconeogenesis 2 65 0.2046 0.5187
67 hsa04920_Adipocytokine_signaling_pathway 2 68 0.2188 0.5395
68 hsa04730_Long.term_depression 2 70 0.2283 0.5553
69 hsa04350_TGF.beta_signaling_pathway 2 85 0.3 0.6835
70 hsa04020_Calcium_signaling_pathway 3 177 0.4003 0.8579

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 SNHG14 hsa-let-7g-5p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-324-3p;hsa-miR-331-5p;hsa-miR-425-3p;hsa-miR-429 10 DUSP1 Sponge network -1.168 0 -2.095 0 0.318

Quest ID: c75aefab433f11fd238dd2a57ed81fc7