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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p AIFM1 -0.33 0.00046 -0.39 0.00049 TargetScan; miRNATAP -0.16 0.00689 NA
2 hsa-let-7d-5p AIFM1 0.05 0.70258 -0.39 0.00049 miRNATAP -0.23 0 NA
3 hsa-let-7e-5p AIFM1 0.04 0.81107 -0.39 0.00049 miRNATAP -0.27 0 NA
4 hsa-let-7i-5p AIFM1 -0.14 0.15414 -0.39 0.00049 miRNATAP -0.27 0 NA
5 hsa-miR-125a-5p AIFM1 -0.91 0 -0.39 0.00049 miRanda -0.14 0 NA
6 hsa-miR-20a-3p AIFM1 -0.32 0.04679 -0.39 0.00049 miRNATAP -0.11 0.00067 NA
7 hsa-miR-425-5p AIFM1 0.59 2.0E-5 -0.39 0.00049 miRNATAP -0.15 8.0E-5 NA
8 hsa-miR-21-5p AKT2 1.51 0 -0.34 1.0E-5 miRNAWalker2 validate -0.25 0 NA
9 hsa-miR-330-5p AKT2 0.44 0.00533 -0.34 1.0E-5 miRanda -0.1 1.0E-5 NA
10 hsa-miR-342-3p AKT2 -0.32 0.04498 -0.34 1.0E-5 mirMAP -0.12 0 NA
11 hsa-miR-106b-5p AKT3 0.65 0 -0.66 0.00047 miRNATAP -0.26 0.00148 NA
12 hsa-miR-107 AKT3 0.24 0.01708 -0.66 0.00047 PITA; miRanda -0.6 0 NA
13 hsa-miR-122-5p AKT3 -1.24 0 -0.66 0.00047 miRNAWalker2 validate; miRTarBase -0.28 0 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer
14 hsa-miR-146b-5p AKT3 0.42 0.04574 -0.66 0.00047 miRNAWalker2 validate -0.16 0.00026 NA
15 hsa-miR-15a-5p AKT3 0.35 0.00077 -0.66 0.00047 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0.00291 NA
16 hsa-miR-17-3p AKT3 0.41 0.00422 -0.66 0.00047 miRNATAP -0.35 0 NA
17 hsa-miR-17-5p AKT3 0.7 2.0E-5 -0.66 0.00047 TargetScan; miRNATAP -0.29 0 NA
18 hsa-miR-20a-5p AKT3 0.85 0 -0.66 0.00047 miRNATAP -0.29 0 NA
19 hsa-miR-32-3p AKT3 0.22 0.20722 -0.66 0.00047 mirMAP -0.23 4.0E-5 NA
20 hsa-miR-33a-3p AKT3 -0.68 1.0E-5 -0.66 0.00047 mirMAP -0.23 0.0001 NA
21 hsa-miR-362-3p AKT3 0.81 0 -0.66 0.00047 miRanda -0.22 0.00083 NA
22 hsa-miR-362-5p AKT3 0.72 2.0E-5 -0.66 0.00047 PITA; TargetScan; miRNATAP -0.15 0.00734 NA
23 hsa-miR-374a-5p AKT3 0.02 0.86978 -0.66 0.00047 mirMAP -0.28 0.00294 NA
24 hsa-miR-502-3p AKT3 0.66 0 -0.66 0.00047 miRNATAP -0.26 0.0008 NA
25 hsa-miR-616-5p AKT3 0.15 0.40284 -0.66 0.00047 mirMAP -0.2 0.0001 NA
26 hsa-miR-93-5p AKT3 1.4 0 -0.66 0.00047 miRNATAP -0.28 1.0E-5 NA
27 hsa-miR-30d-3p ATM -0.12 0.32955 -0.24 0.01738 mirMAP -0.14 0.00043 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC
28 hsa-miR-339-5p ATM 0.28 0.03557 -0.24 0.01738 miRanda -0.1 0.00399 NA
29 hsa-miR-455-5p ATM -0.27 0.05813 -0.24 0.01738 miRanda -0.12 0.00045 NA
30 hsa-miR-30a-5p BAX -0.63 0.00011 0.8 0 miRNAWalker2 validate -0.12 0.00058 NA
31 hsa-miR-365a-3p BAX 0.16 0.15325 0.8 0 miRNAWalker2 validate -0.23 0 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX
32 hsa-miR-103a-3p BCL2 0.77 0 -0.35 0.02497 miRNAWalker2 validate -0.28 4.0E-5 NA
33 hsa-miR-130b-5p BCL2 0.17 0.33761 -0.35 0.02497 mirMAP -0.17 7.0E-5 27364335 The level of microRNA-130b in relationship with the expression of PPARĪ³ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARĪ³ up-regulation of VEGF-A and BCL-2 and decreased apoptosis
34 hsa-miR-148a-3p BCL2 -0.75 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 21455217; 23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a
35 hsa-miR-17-5p BCL2 0.7 2.0E-5 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2
36 hsa-miR-186-5p BCL2 -0.06 0.53529 -0.35 0.02497 mirMAP -0.25 0.00125 NA
37 hsa-miR-192-5p BCL2 -0.5 0.00345 -0.35 0.02497 miRNAWalker2 validate -0.34 0 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
38 hsa-miR-20a-3p BCL2 -0.32 0.04679 -0.35 0.02497 mirMAP -0.24 0 NA
39 hsa-miR-20a-5p BCL2 0.85 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 NA
40 hsa-miR-32-3p BCL2 0.22 0.20722 -0.35 0.02497 mirMAP -0.2 1.0E-5 NA
41 hsa-miR-365a-3p BCL2 0.16 0.15325 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.33 0 NA
42 hsa-miR-455-5p BCL2 -0.27 0.05813 -0.35 0.02497 mirMAP -0.19 0.00037 NA
43 hsa-miR-590-5p BCL2 -0.1 0.31003 -0.35 0.02497 miRanda -0.29 0.00011 NA
44 hsa-miR-616-5p BCL2 0.15 0.40284 -0.35 0.02497 mirMAP -0.28 0 NA
45 hsa-miR-618 BCL2 0.14 0.51715 -0.35 0.02497 mirMAP -0.21 0 NA
46 hsa-miR-330-5p BCL2L1 0.44 0.00533 0.02 0.82745 PITA; miRanda; miRNATAP -0.15 0 NA
47 hsa-miR-342-3p BCL2L1 -0.32 0.04498 0.02 0.82745 PITA; miRanda; miRNATAP -0.12 8.0E-5 NA
48 hsa-miR-342-5p BCL2L1 -0.78 0 0.02 0.82745 miRNATAP -0.11 0.00084 NA
49 hsa-miR-484 BCL2L1 0.09 0.45398 0.02 0.82745 miRNAWalker2 validate -0.21 0 NA
50 hsa-miR-140-5p BID -0.22 0.01407 0.21 0.07516 miRanda -0.21 0.00101 NA
51 hsa-miR-24-1-5p BIRC3 -1.32 0 0.35 0.15976 MirTarget -0.3 0.0004 NA
52 hsa-miR-26b-5p BIRC3 -1.11 0 0.35 0.15976 mirMAP -0.35 0.00041 NA
53 hsa-miR-374a-5p BIRC3 0.02 0.86978 0.35 0.15976 mirMAP -0.56 0 NA
54 hsa-miR-374b-5p BIRC3 -0.31 0.00301 0.35 0.15976 mirMAP -0.3 0.0093 NA
55 hsa-miR-651-5p BIRC3 -0.24 0.08175 0.35 0.15976 MirTarget -0.28 0.00126 NA
56 hsa-miR-664a-3p BIRC3 0.49 0.00073 0.35 0.15976 mirMAP -0.27 0.00118 NA
57 hsa-miR-140-5p CAPN1 -0.22 0.01407 0.2 0.01338 miRanda; miRNATAP -0.15 0.00087 NA
58 hsa-miR-101-3p CAPN2 -1.48 0 0.66 0 miRNAWalker2 validate; MirTarget -0.21 0 NA
59 hsa-miR-107 CAPN2 0.24 0.01708 0.66 0 miRanda -0.2 0.00125 NA
60 hsa-miR-16-2-3p CAPN2 -0.03 0.80516 0.66 0 mirMAP -0.15 0.0006 NA
61 hsa-miR-20a-3p CAPN2 -0.32 0.04679 0.66 0 MirTarget -0.13 0.00067 NA
62 hsa-miR-33a-3p CAPN2 -0.68 1.0E-5 0.66 0 mirMAP -0.13 0.00096 NA
63 hsa-miR-590-3p CAPN2 -0.47 2.0E-5 0.66 0 miRanda -0.22 5.0E-5 NA
64 hsa-miR-590-5p CAPN2 -0.1 0.31003 0.66 0 miRanda -0.24 5.0E-5 NA
65 hsa-let-7g-5p CASP3 -0.46 2.0E-5 0.31 0.00047 MirTarget; miRNATAP -0.11 0.00694 NA
66 hsa-miR-374b-5p CASP3 -0.31 0.00301 0.31 0.00047 mirMAP -0.14 0.00058 NA
67 hsa-miR-455-5p CASP8 -0.27 0.05813 0.33 0.00029 miRanda -0.15 0 NA
68 hsa-miR-542-3p CASP8 -1.31 0 0.33 0.00029 miRanda -0.13 4.0E-5 NA
69 hsa-miR-107 CFLAR 0.24 0.01708 -0.33 0 miRanda -0.15 1.0E-5 NA
70 hsa-miR-455-5p CFLAR -0.27 0.05813 -0.33 0 miRanda -0.11 0 NA
71 hsa-miR-660-5p CFLAR 0.99 0 -0.33 0 mirMAP -0.13 0 NA
72 hsa-miR-15a-5p CHUK 0.35 0.00077 -0.2 0.00863 miRNAWalker2 validate; miRTarBase; MirTarget -0.12 0.00057 NA
73 hsa-miR-15b-5p CHUK 0.23 0.08248 -0.2 0.00863 MirTarget -0.12 2.0E-5 NA
74 hsa-miR-16-5p CHUK -0.4 0.0001 -0.2 0.00863 miRNAWalker2 validate; miRTarBase; MirTarget -0.15 3.0E-5 NA
75 hsa-miR-23a-3p CHUK -0.18 0.13598 -0.2 0.00863 MirTarget -0.1 0.00114 NA
76 hsa-miR-339-5p CHUK 0.28 0.03557 -0.2 0.00863 miRanda -0.12 1.0E-5 NA
77 hsa-miR-590-5p CHUK -0.1 0.31003 -0.2 0.00863 miRanda -0.12 0.00129 NA
78 hsa-miR-19a-3p CSF2RB 1.02 0 -0.51 0.00683 MirTarget -0.12 0.00885 NA
79 hsa-miR-19b-3p CSF2RB 0.6 0.00017 -0.51 0.00683 MirTarget -0.15 0.00713 NA
80 hsa-miR-204-5p CSF2RB -0.54 0.03309 -0.51 0.00683 MirTarget -0.11 0.00224 NA
81 hsa-miR-30b-3p CSF2RB -0.44 0.00095 -0.51 0.00683 MirTarget -0.2 0.00366 NA
82 hsa-miR-455-5p CSF2RB -0.27 0.05813 -0.51 0.00683 miRanda -0.37 0 NA
83 hsa-miR-532-5p CSF2RB 1.03 0 -0.51 0.00683 MirTarget -0.33 0 NA
84 hsa-miR-361-5p CYCS 0.23 0.00962 0.26 0.01519 miRNAWalker2 validate -0.17 0.00331 NA
85 hsa-let-7b-5p DFFA -0.96 0 0.07 0.4191 miRNAWalker2 validate -0.11 8.0E-5 NA
86 hsa-miR-26a-5p DFFA -0.96 0 0.07 0.4191 mirMAP -0.16 4.0E-5 NA
87 hsa-miR-365a-3p DFFB 0.16 0.15325 0.3 0.00331 MirTarget -0.12 0.00456 NA
88 hsa-miR-130b-3p ENDOD1 0.69 0.00011 -1 0 MirTarget -0.31 0 NA
89 hsa-miR-16-1-3p ENDOD1 0.39 0.00112 -1 0 mirMAP -0.45 0 NA
90 hsa-miR-192-5p ENDOD1 -0.5 0.00345 -1 0 miRNAWalker2 validate -0.46 0 NA
91 hsa-miR-193b-3p ENDOD1 -0.17 0.27202 -1 0 miRNAWalker2 validate -0.22 0.0003 NA
92 hsa-miR-19a-3p ENDOD1 1.02 0 -1 0 mirMAP -0.28 0 NA
93 hsa-miR-19b-3p ENDOD1 0.6 0.00017 -1 0 mirMAP -0.34 0 NA
94 hsa-miR-20a-3p ENDOD1 -0.32 0.04679 -1 0 MirTarget -0.28 0 NA
95 hsa-miR-224-3p ENDOD1 1.41 0 -1 0 mirMAP -0.1 0.0066 NA
96 hsa-miR-361-5p ENDOD1 0.23 0.00962 -1 0 MirTarget; miRanda -0.62 0 NA
97 hsa-miR-3613-5p ENDOD1 0.11 0.42651 -1 0 MirTarget -0.21 0.00254 NA
98 hsa-miR-362-3p ENDOD1 0.81 0 -1 0 miRanda -0.34 0 NA
99 hsa-miR-589-3p ENDOD1 1.17 0 -1 0 mirMAP -0.21 5.0E-5 NA
100 hsa-miR-589-5p ENDOD1 1.19 0 -1 0 MirTarget -0.56 0 NA
101 hsa-miR-542-3p EXOG -1.31 0 0.81 0 miRanda -0.11 0.0009 NA
102 hsa-miR-106a-5p FAS -0.46 0.00972 -1.02 0 miRNAWalker2 validate; miRTarBase -0.3 0 22431000; 27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway
103 hsa-miR-21-5p FAS 1.51 0 -1.02 0 miRNAWalker2 validate -0.35 0 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7
104 hsa-miR-338-3p FAS 0.54 0.00461 -1.02 0 miRanda -0.23 0 NA
105 hsa-miR-361-5p FAS 0.23 0.00962 -1.02 0 miRanda -0.4 0.00016 NA
106 hsa-miR-590-5p FAS -0.1 0.31003 -1.02 0 miRanda -0.56 0 NA
107 hsa-miR-98-5p FAS -0.05 0.71591 -1.02 0 miRNAWalker2 validate -0.18 0.00981 NA
108 hsa-miR-25-3p FASLG 0.63 0 -0.79 0.00091 miRNATAP -0.41 0.00032 NA
109 hsa-miR-125a-5p IKBKG -0.91 0 0.66 0 miRanda -0.22 0 NA
110 hsa-miR-143-3p IKBKG -0.58 0.00091 0.66 0 mirMAP -0.17 1.0E-5 NA
111 hsa-miR-200a-3p IKBKG -1.5 3.0E-5 0.66 0 mirMAP -0.1 0 NA
112 hsa-miR-24-3p IKBKG -0.26 0.0069 0.66 0 mirMAP -0.29 6.0E-5 NA
113 hsa-miR-3065-3p IKBKG -1.04 5.0E-5 0.66 0 mirMAP -0.12 1.0E-5 NA
114 hsa-miR-320a IKBKG 0.33 0.02214 0.66 0 mirMAP -0.18 0.00013 NA
115 hsa-miR-320b IKBKG 0.09 0.60798 0.66 0 mirMAP -0.13 0.00052 NA
116 hsa-miR-335-5p IKBKG -1.61 0 0.66 0 mirMAP -0.27 0 NA
117 hsa-miR-338-5p IKBKG -0.22 0.25239 0.66 0 mirMAP -0.21 0 NA
118 hsa-miR-376c-3p IKBKG -1.79 0 0.66 0 mirMAP -0.14 0 NA
119 hsa-miR-542-3p IKBKG -1.31 0 0.66 0 mirMAP -0.29 0 NA
120 hsa-miR-17-3p IL1R1 0.41 0.00422 -1.01 0 mirMAP -0.39 0 NA
121 hsa-miR-181a-5p IL1R1 0.25 0.05519 -1.01 0 mirMAP -0.23 1.0E-5 NA
122 hsa-miR-181b-5p IL1R1 0.49 0.00105 -1.01 0 mirMAP -0.25 0 NA
123 hsa-miR-29b-3p IL1RAP -0.35 0.01214 -2.29 0 MirTarget; miRNATAP -0.24 0.00132 NA
124 hsa-miR-421 IL1RAP 0.94 0 -2.29 0 MirTarget; miRanda -0.18 0.00237 NA
125 hsa-miR-93-5p IL1RAP 1.4 0 -2.29 0 MirTarget -0.29 7.0E-5 NA
126 hsa-miR-142-3p IRAK1 -1.42 0 1.22 0 PITA; miRanda; miRNATAP -0.1 0.00154 NA
127 hsa-miR-328-3p IRAK1 -0.55 1.0E-5 1.22 0 miRNAWalker2 validate -0.17 0.00081 NA
128 hsa-miR-188-5p IRAK3 1.12 0 -1.13 0 mirMAP -0.16 0.0029 NA
129 hsa-miR-20a-3p IRAK3 -0.32 0.04679 -1.13 0 mirMAP -0.18 0.00282 NA
130 hsa-miR-224-3p IRAK3 1.41 0 -1.13 0 mirMAP -0.13 0.00062 NA
131 hsa-miR-25-3p IRAK3 0.63 0 -1.13 0 mirMAP -0.5 0 NA
132 hsa-miR-32-5p IRAK3 0.08 0.54898 -1.13 0 mirMAP -0.2 0.00353 NA
133 hsa-miR-3200-3p IRAK3 1.4 0 -1.13 0 mirMAP -0.14 6.0E-5 NA
134 hsa-miR-324-5p IRAK3 0.37 0.00592 -1.13 0 miRanda -0.19 0.00586 NA
135 hsa-miR-33a-5p IRAK3 -0.77 1.0E-5 -1.13 0 mirMAP -0.17 0.00159 NA
136 hsa-miR-361-5p IRAK3 0.23 0.00962 -1.13 0 miRanda; mirMAP -0.37 0.00049 NA
137 hsa-miR-452-3p IRAK3 1.77 0 -1.13 0 mirMAP -0.11 0.00056 NA
138 hsa-miR-589-3p IRAK3 1.17 0 -1.13 0 mirMAP -0.2 0.00011 NA
139 hsa-miR-616-5p IRAK3 0.15 0.40284 -1.13 0 mirMAP -0.2 0.00013 NA
140 hsa-miR-660-5p IRAK3 0.99 0 -1.13 0 mirMAP -0.28 6.0E-5 NA
141 hsa-miR-92a-3p IRAK3 0.21 0.13429 -1.13 0 mirMAP -0.29 1.0E-5 NA
142 hsa-miR-30d-3p IRAK4 -0.12 0.32955 0.02 0.75053 mirMAP -0.13 0 NA
143 hsa-miR-17-3p MAP3K14 0.41 0.00422 -0.26 0.0806 MirTarget -0.13 0.00706 NA
144 hsa-miR-17-5p MAP3K14 0.7 2.0E-5 -0.26 0.0806 MirTarget -0.2 0 NA
145 hsa-miR-20a-5p MAP3K14 0.85 0 -0.26 0.0806 MirTarget -0.16 0.00014 NA
146 hsa-miR-874-3p MAP3K14 -1.07 0 -0.26 0.0806 MirTarget -0.12 0.00031 NA
147 hsa-miR-330-5p MYD88 0.44 0.00533 -1.1 0 MirTarget; miRanda -0.16 0 NA
148 hsa-miR-660-5p MYD88 0.99 0 -1.1 0 MirTarget -0.17 0 NA
149 hsa-miR-15a-5p NFKB1 0.35 0.00077 -0.54 0 miRNAWalker2 validate -0.15 0.00073 NA
150 hsa-miR-548j-5p NFKB1 0.25 0.17136 -0.54 0 MirTarget -0.11 5.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 37 1572 2.326e-27 1.082e-23
2 POSITIVE REGULATION OF RESPONSE TO STIMULUS 39 1929 9.347e-27 2.175e-23
3 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 13 39 1.439e-24 2.232e-21
4 APOPTOTIC SIGNALING PATHWAY 20 289 6.092e-23 7.086e-20
5 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 15 99 1.614e-22 1.502e-19
6 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 35 1848 2.141e-22 1.66e-19
7 REGULATION OF CELL DEATH 32 1472 6.509e-22 4.327e-19
8 CELL DEATH 28 1001 9.917e-22 5.768e-19
9 RESPONSE TO OXYGEN CONTAINING COMPOUND 31 1381 1.582e-21 8.181e-19
10 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 31 1492 1.535e-20 7.141e-18
11 POSITIVE REGULATION OF MOLECULAR FUNCTION 33 1791 1.764e-20 7.462e-18
12 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 32 1656 2.303e-20 8.928e-18
13 POSITIVE REGULATION OF CELL COMMUNICATION 31 1532 3.328e-20 1.191e-17
14 NEGATIVE REGULATION OF CELL DEATH 25 872 1.826e-19 6.068e-17
15 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 876 2.037e-19 6.319e-17
16 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 13 95 5.511e-19 1.603e-16
17 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 16 213 6.11e-19 1.672e-16
18 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 15 179 1.661e-18 4.293e-16
19 IMMUNE SYSTEM PROCESS 32 1984 5.085e-18 1.148e-15
20 POSITIVE REGULATION OF CATALYTIC ACTIVITY 29 1518 4.863e-18 1.148e-15
21 ZYMOGEN ACTIVATION 13 112 5.182e-18 1.148e-15
22 RESPONSE TO NITROGEN COMPOUND 23 859 3.594e-17 7.601e-15
23 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 15 233 8.981e-17 1.741e-14
24 ACTIVATION OF IMMUNE RESPONSE 18 427 8.608e-17 1.741e-14
25 REGULATION OF IMMUNE SYSTEM PROCESS 27 1403 9.843e-17 1.832e-14
26 POSITIVE REGULATION OF CELL DEATH 20 605 1.286e-16 2.302e-14
27 RESPONSE TO CYTOKINE 21 714 1.924e-16 3.316e-14
28 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 13 154 3.657e-16 6.077e-14
29 REGULATION OF IMMUNE RESPONSE 22 858 5.289e-16 8.486e-14
30 PROTEIN MATURATION 15 265 6.146e-16 9.225e-14
31 POSITIVE REGULATION OF IMMUNE RESPONSE 19 563 6.057e-16 9.225e-14
32 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 171 1.453e-15 2.112e-13
33 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 13 1.765e-15 2.489e-13
34 REGULATION OF TRANSFERASE ACTIVITY 22 946 3.986e-15 5.455e-13
35 REGULATION OF PEPTIDASE ACTIVITY 16 392 9.742e-15 1.295e-12
36 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 12 153 1.365e-14 1.764e-12
37 REGULATION OF KINASE ACTIVITY 20 776 1.469e-14 1.799e-12
38 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 23 1135 1.464e-14 1.799e-12
39 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 17 1.983e-14 2.366e-12
40 RESPONSE TO ENDOGENOUS STIMULUS 25 1450 2.723e-14 3.167e-12
41 REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 1618 3.461e-14 3.928e-12
42 REGULATION OF PROTEOLYSIS 19 711 4.138e-14 4.584e-12
43 NEURON APOPTOTIC PROCESS 8 35 5.783e-14 6.258e-12
44 REGULATION OF APOPTOTIC SIGNALING PATHWAY 15 363 6.332e-14 6.696e-12
45 PHOSPHORYLATION 23 1228 7.765e-14 8.029e-12
46 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 20 867 1.173e-13 1.187e-11
47 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 22 1.72e-13 1.703e-11
48 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 10 98 1.779e-13 1.725e-11
49 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 14 323 2.554e-13 2.425e-11
50 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 21 1036 2.947e-13 2.689e-11
51 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1036 2.947e-13 2.689e-11
52 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 19 799 3.311e-13 2.963e-11
53 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 27 1977 4.521e-13 3.969e-11
54 INTRINSIC APOPTOTIC SIGNALING PATHWAY 11 152 4.631e-13 3.99e-11
55 CELLULAR RESPONSE TO NITROGEN COMPOUND 16 505 4.816e-13 4.074e-11
56 NEURON DEATH 8 47 7.527e-13 6.254e-11
57 ACTIVATION OF PROTEIN KINASE ACTIVITY 13 279 8.114e-13 6.624e-11
58 REGULATION OF PROTEIN MODIFICATION PROCESS 25 1710 1.128e-12 9.047e-11
59 RESPONSE TO TUMOR NECROSIS FACTOR 12 233 2.096e-12 1.653e-10
60 RESPONSE TO HORMONE 19 893 2.35e-12 1.823e-10
61 RESPONSE TO ABIOTIC STIMULUS 20 1024 2.537e-12 1.935e-10
62 POSITIVE REGULATION OF KINASE ACTIVITY 15 482 3.775e-12 2.833e-10
63 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 7 34 5.284e-12 3.903e-10
64 PROTEIN PHOSPHORYLATION 19 944 6.199e-12 4.507e-10
65 CELLULAR RESPONSE TO CYTOKINE STIMULUS 16 606 7.593e-12 5.436e-10
66 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 36 8.164e-12 5.755e-10
67 CELLULAR RESPONSE TO ABIOTIC STIMULUS 12 263 8.705e-12 6.046e-10
68 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 11 200 9.371e-12 6.412e-10
69 ACTIVATION OF INNATE IMMUNE RESPONSE 11 204 1.162e-11 7.835e-10
70 I KAPPAB KINASE NF KAPPAB SIGNALING 8 70 2.149e-11 1.408e-09
71 REGULATION OF MEMBRANE PERMEABILITY 8 70 2.149e-11 1.408e-09
72 POSITIVE REGULATION OF PROTEOLYSIS 13 363 2.231e-11 1.442e-09
73 POSITIVE REGULATION OF DEFENSE RESPONSE 13 364 2.309e-11 1.472e-09
74 CYTOKINE MEDIATED SIGNALING PATHWAY 14 452 2.354e-11 1.48e-09
75 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 8 71 2.417e-11 1.499e-09
76 REGULATION OF RESPONSE TO STRESS 22 1468 2.728e-11 1.67e-09
77 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 13 370 2.831e-11 1.711e-09
78 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 43 3.103e-11 1.851e-09
79 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 8.165e-11 4.809e-09
80 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 11 246 8.737e-11 5.07e-09
81 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 12 321 8.825e-11 5.07e-09
82 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 7 50 9.473e-11 5.375e-09
83 TOLL LIKE RECEPTOR SIGNALING PATHWAY 8 85 1.06e-10 5.944e-09
84 REGULATION OF NEURON DEATH 11 252 1.131e-10 6.263e-09
85 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 15 616 1.198e-10 6.561e-09
86 REGULATION OF NEURON APOPTOTIC PROCESS 10 192 1.534e-10 8.302e-09
87 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 10 195 1.787e-10 9.557e-09
88 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 6 29 1.845e-10 9.648e-09
89 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 6 29 1.845e-10 9.648e-09
90 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 7 55 1.904e-10 9.842e-09
91 MITOCHONDRIAL MEMBRANE ORGANIZATION 8 92 2.02e-10 1.033e-08
92 RESPONSE TO BIOTIC STIMULUS 17 886 2.201e-10 1.113e-08
93 FC EPSILON RECEPTOR SIGNALING PATHWAY 9 142 2.391e-10 1.197e-08
94 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 9 144 2.71e-10 1.342e-08
95 CELLULAR RESPONSE TO PEPTIDE 11 274 2.758e-10 1.351e-08
96 REGULATION OF INNATE IMMUNE RESPONSE 12 357 2.992e-10 1.45e-08
97 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 12 360 3.293e-10 1.58e-08
98 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 13 470 5.398e-10 2.563e-08
99 CELLULAR RESPONSE TO STRESS 21 1565 6.963e-10 3.273e-08
100 IMMUNE RESPONSE 18 1100 7.429e-10 3.457e-08
101 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 109 7.942e-10 3.659e-08
102 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 9.471e-10 4.321e-08
103 RESPONSE TO PEPTIDE 12 404 1.222e-09 5.521e-08
104 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 8 118 1.499e-09 6.709e-08
105 CHEMICAL HOMEOSTASIS 16 874 1.66e-09 7.357e-08
106 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 1.715e-09 7.457e-08
107 RESPONSE TO EXTERNAL STIMULUS 22 1821 1.702e-09 7.457e-08
108 CELLULAR GLUCOSE HOMEOSTASIS 7 75 1.782e-09 7.678e-08
109 REGULATION OF HYDROLASE ACTIVITY 19 1327 2.04e-09 8.708e-08
110 RESPONSE TO LIPID 16 888 2.086e-09 8.825e-08
111 REGULATION OF DEFENSE RESPONSE 15 759 2.123e-09 8.9e-08
112 REGULATION OF CELL PROLIFERATION 20 1496 2.19e-09 9.097e-08
113 RESPONSE TO BACTERIUM 13 528 2.212e-09 9.109e-08
114 HOMEOSTATIC PROCESS 19 1337 2.31e-09 9.43e-08
115 POSITIVE REGULATION OF HYDROLASE ACTIVITY 16 905 2.738e-09 1.108e-07
116 CELLULAR RESPONSE TO MECHANICAL STIMULUS 7 80 2.821e-09 1.132e-07
117 PROTEOLYSIS 18 1208 3.292e-09 1.309e-07
118 CELLULAR RESPONSE TO EXTERNAL STIMULUS 10 264 3.39e-09 1.337e-07
119 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 8 132 3.661e-09 1.431e-07
120 CELLULAR RESPONSE TO HORMONE STIMULUS 13 552 3.775e-09 1.452e-07
121 REGULATION OF CELLULAR PROTEIN LOCALIZATION 13 552 3.775e-09 1.452e-07
122 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 6 47 4.01e-09 1.53e-07
123 RESPONSE TO WOUNDING 13 563 4.781e-09 1.809e-07
124 FC RECEPTOR SIGNALING PATHWAY 9 206 6.426e-09 2.392e-07
125 REGULATION OF EXECUTION PHASE OF APOPTOSIS 5 24 6.408e-09 2.392e-07
126 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 7.992e-09 2.951e-07
127 T CELL RECEPTOR SIGNALING PATHWAY 8 146 8.122e-09 2.976e-07
128 REGULATION OF MITOCHONDRION ORGANIZATION 9 218 1.052e-08 3.826e-07
129 REGULATION OF CATABOLIC PROCESS 14 731 1.202e-08 4.334e-07
130 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 16 1008 1.267e-08 4.533e-07
131 REGULATION OF INTRACELLULAR TRANSPORT 13 621 1.535e-08 5.454e-07
132 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 9 228 1.553e-08 5.467e-07
133 RENAL SYSTEM PROCESS 7 102 1.563e-08 5.467e-07
134 REGULATION OF ORGANELLE ORGANIZATION 17 1178 1.63e-08 5.659e-07
135 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 12 514 1.806e-08 6.224e-07
136 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 8 167 2.331e-08 7.974e-07
137 RESPONSE TO ORGANIC CYCLIC COMPOUND 15 917 2.689e-08 9.133e-07
138 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 2.884e-08 9.726e-07
139 RESPONSE TO AMINO ACID 7 112 2.999e-08 1.004e-06
140 NEGATIVE REGULATION OF MOLECULAR FUNCTION 16 1079 3.288e-08 1.093e-06
141 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 5 33 3.509e-08 1.15e-06
142 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 5 33 3.509e-08 1.15e-06
143 POSITIVE REGULATION OF NEURON DEATH 6 67 3.568e-08 1.161e-06
144 MITOCHONDRIAL TRANSPORT 8 177 3.667e-08 1.185e-06
145 RENAL WATER HOMEOSTASIS 5 34 4.105e-08 1.317e-06
146 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 5.125e-08 1.633e-06
147 INFLAMMATORY RESPONSE 11 454 5.265e-08 1.667e-06
148 INOSITOL LIPID MEDIATED SIGNALING 7 124 6.07e-08 1.908e-06
149 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 6 74 6.522e-08 2.037e-06
150 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 7.171e-08 2.225e-06
151 CELLULAR RESPONSE TO GLUCAGON STIMULUS 5 38 7.341e-08 2.262e-06
152 WOUND HEALING 11 470 7.479e-08 2.289e-06
153 T CELL APOPTOTIC PROCESS 4 15 7.904e-08 2.404e-06
154 MITOCHONDRION ORGANIZATION 12 594 8.802e-08 2.659e-06
155 NIK NF KAPPAB SIGNALING 6 83 1.303e-07 3.886e-06
156 NEGATIVE REGULATION OF CELL COMMUNICATION 16 1192 1.301e-07 3.886e-06
157 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 17 1360 1.324e-07 3.925e-06
158 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 1.372e-07 4.041e-06
159 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 1.425e-07 4.17e-06
160 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 5 44 1.568e-07 4.559e-06
161 LYMPHOCYTE APOPTOTIC PROCESS 4 18 1.761e-07 5.088e-06
162 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 5 46 1.97e-07 5.659e-06
163 HEMOSTASIS 9 311 2.213e-07 6.317e-06
164 RESPONSE TO GLUCAGON 5 48 2.45e-07 6.952e-06
165 POSITIVE REGULATION OF TRANSPORT 14 936 2.572e-07 7.253e-06
166 RESPONSE TO GAMMA RADIATION 5 50 3.019e-07 8.462e-06
167 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 3.246e-07 9.043e-06
168 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 5 51 3.34e-07 9.25e-06
169 CELLULAR HOMEOSTASIS 12 676 3.538e-07 9.742e-06
170 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 52 3.687e-07 1.009e-05
171 LIPID PHOSPHORYLATION 6 99 3.735e-07 1.016e-05
172 RESPONSE TO TOXIC SUBSTANCE 8 241 3.931e-07 1.063e-05
173 POSITIVE REGULATION OF PROTEIN OLIGOMERIZATION 4 22 4.173e-07 1.116e-05
174 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 22 4.173e-07 1.116e-05
175 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 13 829 4.381e-07 1.165e-05
176 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 103 4.724e-07 1.249e-05
177 RESPONSE TO CARBOHYDRATE 7 168 4.835e-07 1.271e-05
178 EXECUTION PHASE OF APOPTOSIS 5 55 4.903e-07 1.282e-05
179 CELL ACTIVATION 11 568 4.968e-07 1.292e-05
180 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 5.041e-07 1.296e-05
181 LEUKOCYTE APOPTOTIC PROCESS 4 23 5.041e-07 1.296e-05
182 CELLULAR CHEMICAL HOMEOSTASIS 11 570 5.144e-07 1.315e-05
183 GLUCOSE HOMEOSTASIS 7 170 5.237e-07 1.324e-05
184 CARBOHYDRATE HOMEOSTASIS 7 170 5.237e-07 1.324e-05
185 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 11 573 5.417e-07 1.363e-05
186 RESPONSE TO OXIDATIVE STRESS 9 352 6.254e-07 1.565e-05
187 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 5 58 6.417e-07 1.597e-05
188 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 8 258 6.585e-07 1.63e-05
189 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 12 720 6.909e-07 1.701e-05
190 REGULATION OF GLUCOSE IMPORT 5 60 7.615e-07 1.865e-05
191 POSITIVE REGULATION OF GENE EXPRESSION 18 1733 8.064e-07 1.964e-05
192 REGULATION OF NECROTIC CELL DEATH 4 26 8.457e-07 2.039e-05
193 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 9 365 8.458e-07 2.039e-05
194 RESPONSE TO INTERLEUKIN 1 6 115 9.056e-07 2.172e-05
195 MULTICELLULAR ORGANISMAL HOMEOSTASIS 8 272 9.802e-07 2.339e-05
196 DNA CATABOLIC PROCESS 4 27 9.906e-07 2.352e-05
197 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 1.153e-06 2.697e-05
198 NECROTIC CELL DEATH 4 28 1.153e-06 2.697e-05
199 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 28 1.153e-06 2.697e-05
200 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 8 282 1.285e-06 2.974e-05
201 REGULATION OF LIPID METABOLIC PROCESS 8 282 1.285e-06 2.974e-05
202 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 30 1.537e-06 3.54e-05
203 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 14 1087 1.544e-06 3.54e-05
204 WATER HOMEOSTASIS 5 70 1.651e-06 3.767e-05
205 LEUKOCYTE DIFFERENTIATION 8 292 1.667e-06 3.783e-05
206 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 6 128 1.697e-06 3.832e-05
207 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 1.892e-06 4.252e-05
208 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 32 2.008e-06 4.471e-05
209 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 2.008e-06 4.471e-05
210 REGULATION OF PROTEIN LOCALIZATION 13 950 2.019e-06 4.473e-05
211 B CELL ACTIVATION 6 132 2.03e-06 4.477e-05
212 RESPONSE TO MECHANICAL STIMULUS 7 210 2.157e-06 4.734e-05
213 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 4 33 2.281e-06 4.982e-05
214 RESPONSE TO ALKALOID 6 137 2.521e-06 5.481e-05
215 T CELL HOMEOSTASIS 4 34 2.579e-06 5.582e-05
216 RESPONSE TO OXYGEN LEVELS 8 311 2.663e-06 5.737e-05
217 REGULATION OF PROTEIN OLIGOMERIZATION 4 35 2.906e-06 6.231e-05
218 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 220 2.936e-06 6.266e-05
219 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 1152 3.054e-06 6.489e-05
220 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 3.21e-06 6.767e-05
221 REGULATION OF MAP KINASE ACTIVITY 8 319 3.214e-06 6.767e-05
222 NEGATIVE REGULATION OF CELL CYCLE 9 433 3.447e-06 7.224e-05
223 RESPONSE TO IONIZING RADIATION 6 145 3.504e-06 7.31e-05
224 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 11 3.563e-06 7.402e-05
225 PEPTIDYL SERINE MODIFICATION 6 148 3.944e-06 8.157e-05
226 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 7 233 4.288e-06 8.828e-05
227 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 5.018e-06 0.0001029
228 IMMUNE SYSTEM DEVELOPMENT 10 582 5.08e-06 0.0001037
229 CELLULAR RESPONSE TO INTERLEUKIN 1 5 88 5.141e-06 0.000104
230 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 88 5.141e-06 0.000104
231 LYMPHOCYTE ACTIVATION 8 342 5.366e-06 0.0001081
232 HEPATOCYTE APOPTOTIC PROCESS 3 13 6.151e-06 0.0001218
233 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 6.12e-06 0.0001218
234 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 3 13 6.151e-06 0.0001218
235 RESPONSE TO COBALT ION 3 13 6.151e-06 0.0001218
236 DEFENSE RESPONSE 14 1231 6.582e-06 0.0001298
237 REGULATION OF AUTOPHAGY 7 249 6.629e-06 0.0001302
238 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 4 43 6.734e-06 0.0001316
239 GLYCEROLIPID METABOLIC PROCESS 8 356 7.197e-06 0.0001401
240 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 5 95 7.489e-06 0.0001452
241 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 3 14 7.813e-06 0.000149
242 RESPONSE TO INORGANIC SUBSTANCE 9 479 7.796e-06 0.000149
243 LEUKOCYTE CELL CELL ADHESION 7 255 7.745e-06 0.000149
244 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 3 14 7.813e-06 0.000149
245 REGULATION OF CYTOPLASMIC TRANSPORT 9 481 8.062e-06 0.0001531
246 PHOSPHOLIPID METABOLIC PROCESS 8 364 8.462e-06 0.0001601
247 LEUKOCYTE MIGRATION 7 259 8.572e-06 0.0001615
248 NEGATIVE REGULATION OF NEURON DEATH 6 171 9.048e-06 0.0001698
249 REGULATION OF GLUCOSE TRANSPORT 5 100 9.626e-06 0.0001799
250 APOPTOTIC DNA FRAGMENTATION 3 15 9.747e-06 0.0001814
251 REGULATION OF CELLULAR LOCALIZATION 14 1277 1.001e-05 0.0001856
252 REGULATION OF LIPID KINASE ACTIVITY 4 48 1.051e-05 0.000194
253 RESPONSE TO CORTICOSTEROID 6 176 1.067e-05 0.0001962
254 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 1.166e-05 0.0002135
255 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 8 381 1.179e-05 0.0002151
256 REGULATION OF BODY FLUID LEVELS 9 506 1.209e-05 0.0002197
257 LYMPHOCYTE HOMEOSTASIS 4 50 1.238e-05 0.0002242
258 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 106 1.279e-05 0.0002307
259 RESPONSE TO NICOTINE 4 51 1.341e-05 0.0002409
260 PROTEIN COMPLEX BIOGENESIS 13 1132 1.358e-05 0.0002421
261 PROTEIN COMPLEX ASSEMBLY 13 1132 1.358e-05 0.0002421
262 REGULATION OF CELL CYCLE ARREST 5 108 1.401e-05 0.0002488
263 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 17 1.451e-05 0.0002557
264 NEGATIVE REGULATION OF ANOIKIS 3 17 1.451e-05 0.0002557
265 CELLULAR RESPONSE TO AMINO ACID STIMULUS 4 53 1.564e-05 0.0002736
266 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 53 1.564e-05 0.0002736
267 RESPONSE TO REACTIVE OXYGEN SPECIES 6 191 1.698e-05 0.0002959
268 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 8 404 1.799e-05 0.0003123
269 REGULATION OF INFLAMMATORY RESPONSE 7 294 1.947e-05 0.0003367
270 NEGATIVE REGULATION OF MEIOTIC CELL CYCLE 3 19 2.059e-05 0.0003535
271 DNA CATABOLIC PROCESS ENDONUCLEOLYTIC 3 19 2.059e-05 0.0003535
272 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 10 684 2.07e-05 0.0003541
273 APOPTOTIC MITOCHONDRIAL CHANGES 4 57 2.092e-05 0.0003566
274 RESPONSE TO RADIATION 8 413 2.107e-05 0.0003578
275 LEUKOCYTE ACTIVATION 8 414 2.144e-05 0.0003627
276 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 118 2.152e-05 0.0003627
277 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 59 2.401e-05 0.0004018
278 NEGATIVE REGULATION OF CATABOLIC PROCESS 6 203 2.395e-05 0.0004018
279 POSITIVE REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 20 2.417e-05 0.0004032
280 LEUKOCYTE HOMEOSTASIS 4 60 2.567e-05 0.0004265
281 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 2.741e-05 0.0004539
282 B CELL HOMEOSTASIS 3 21 2.815e-05 0.0004622
283 NECROPTOTIC PROCESS 3 21 2.815e-05 0.0004622
284 LYMPHOCYTE DIFFERENTIATION 6 209 2.821e-05 0.0004622
285 RESPONSE TO DRUG 8 431 2.857e-05 0.0004664
286 LIPID MODIFICATION 6 210 2.898e-05 0.0004715
287 REGULATION OF TRANSPORT 16 1804 2.908e-05 0.0004715
288 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 16 1805 2.928e-05 0.0004731
289 RESPONSE TO UV 5 126 2.952e-05 0.0004736
290 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 126 2.952e-05 0.0004736
291 PROTEIN OLIGOMERIZATION 8 434 3.002e-05 0.0004799
292 RESPONSE TO ACID CHEMICAL 7 319 3.281e-05 0.0005229
293 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 5 129 3.305e-05 0.0005249
294 EMBRYO DEVELOPMENT 11 894 3.743e-05 0.0005924
295 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 3.88e-05 0.0006121
296 MEMBRANE ORGANIZATION 11 899 3.938e-05 0.0006191
297 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 135 4.11e-05 0.0006438
298 REGULATION OF ANOIKIS 3 24 4.257e-05 0.0006647
299 RESPONSE TO METAL ION 7 333 4.31e-05 0.0006707
300 CELLULAR RESPONSE TO RADIATION 5 137 4.409e-05 0.0006838
301 SINGLE ORGANISM CELL ADHESION 8 459 4.463e-05 0.0006899
302 CELLULAR LIPID METABOLIC PROCESS 11 913 4.533e-05 0.0006984
303 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 138 4.565e-05 0.000701
304 APOPTOTIC NUCLEAR CHANGES 3 25 4.828e-05 0.0007366
305 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 4.828e-05 0.0007366
306 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 15 1672 4.852e-05 0.0007378
307 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 8 465 4.891e-05 0.0007413
308 ESTABLISHMENT OF LOCALIZATION IN CELL 15 1676 4.988e-05 0.0007536
309 POSITIVE REGULATION OF MAPK CASCADE 8 470 5.273e-05 0.000794
310 CELLULAR RESPONSE TO OXYGEN LEVELS 5 143 5.409e-05 0.0008119
311 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 145 5.779e-05 0.0008646
312 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 5.88e-05 0.0008768
313 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 5.971e-05 0.0008876
314 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 147 6.168e-05 0.000914
315 REGULATION OF CELL CYCLE 11 949 6.43e-05 0.0009498
316 REGULATION OF CELL ACTIVATION 8 484 6.478e-05 0.0009539
317 REGULATION OF CELL ADHESION 9 629 6.638e-05 0.0009744
318 IMMUNE EFFECTOR PROCESS 8 486 6.668e-05 0.0009756
319 POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 3 28 6.835e-05 0.000997
320 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 11 957 6.934e-05 0.001008
321 RESPONSE TO VIRUS 6 247 7.154e-05 0.001037
322 PROTEIN COMPLEX SUBUNIT ORGANIZATION 14 1527 7.297e-05 0.001051
323 RESPONSE TO ALCOHOL 7 362 7.293e-05 0.001051
324 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 3 29 7.609e-05 0.001093
325 RESPONSE TO STEROID HORMONE 8 497 7.795e-05 0.001116
326 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 8 498 7.905e-05 0.001128
327 NEGATIVE REGULATION OF B CELL ACTIVATION 3 30 8.437e-05 0.001201
328 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 7 372 8.648e-05 0.001227
329 JNK CASCADE 4 82 8.787e-05 0.001239
330 REGULATION OF PROTEIN MATURATION 4 82 8.787e-05 0.001239
331 REGULATION OF MAPK CASCADE 9 660 9.589e-05 0.001348
332 POSITIVE REGULATION OF CELL CYCLE ARREST 4 85 0.0001011 0.001417
333 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 32 0.0001027 0.00143
334 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 3 32 0.0001027 0.00143
335 AGING 6 264 0.0001032 0.001433
336 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 1004 0.0001064 0.001473
337 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 88 0.0001157 0.001597
338 B CELL DIFFERENTIATION 4 89 0.0001209 0.001658
339 MACROMOLECULAR COMPLEX ASSEMBLY 13 1398 0.0001212 0.001658
340 EPITHELIAL CELL PROLIFERATION 4 89 0.0001209 0.001658
341 PROTEIN KINASE B SIGNALING 3 34 0.0001233 0.001678
342 CELLULAR RESPONSE TO ALKALOID 3 34 0.0001233 0.001678
343 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 7 397 0.0001295 0.001757
344 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 0.000133 0.001794
345 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 9 689 0.0001328 0.001794
346 LIPID BIOSYNTHETIC PROCESS 8 539 0.0001366 0.001837
347 CELL DEVELOPMENT 13 1426 0.0001478 0.001982
348 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 0.0001556 0.002081
349 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 4 96 0.000162 0.00216
350 REGULATION OF RESPONSE TO WOUNDING 7 413 0.0001652 0.002197
351 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 0.000169 0.00224
352 REGULATION OF PROTEIN IMPORT 5 183 0.0001729 0.002283
353 REGULATION OF CELL CYCLE PROCESS 8 558 0.0001732 0.002283
354 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 4 98 0.0001754 0.002306
355 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0002012 0.00263
356 MYELOID CELL DIFFERENTIATION 5 189 0.000201 0.00263
357 PROTEIN DEPHOSPHORYLATION 5 190 0.0002059 0.002684
358 PROTEIN AUTOPHOSPHORYLATION 5 192 0.0002162 0.00281
359 REGULATION OF CELL DIFFERENTIATION 13 1492 0.0002316 0.003002
360 REGULATION OF NIK NF KAPPAB SIGNALING 3 42 0.0002328 0.00301
361 REGULATION OF PROTEIN TARGETING 6 307 0.0002341 0.003018
362 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 5 197 0.0002435 0.00313
363 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 5 199 0.0002552 0.003271
364 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 10 926 0.0002568 0.003283
365 RESPONSE TO HYDROGEN PEROXIDE 4 109 0.000264 0.003365
366 GAMETE GENERATION 8 595 0.0002677 0.003403
367 MITOTIC CELL CYCLE 9 766 0.0002926 0.0037
368 RESPONSE TO INSULIN 5 205 0.0002927 0.0037
369 REGULATION OF CELLULAR COMPONENT BIOGENESIS 9 767 0.0002954 0.003725
370 OVULATION CYCLE 4 113 0.000303 0.00381
371 POSITIVE REGULATION OF MAP KINASE ACTIVITY 5 207 0.000306 0.003838
372 CELL CELL ADHESION 8 608 0.0003096 0.003872
373 GERM CELL DEVELOPMENT 5 209 0.0003199 0.00399
374 RESPONSE TO ANTIBIOTIC 3 47 0.0003256 0.004051
375 FEMALE SEX DIFFERENTIATION 4 116 0.0003348 0.004154
376 NEGATIVE REGULATION OF PROTEOLYSIS 6 329 0.0003391 0.004197
377 INNATE IMMUNE RESPONSE 8 619 0.0003491 0.004308
378 NEGATIVE REGULATION OF CELL CYCLE PROCESS 5 214 0.0003566 0.004389
379 LIPID METABOLIC PROCESS 11 1158 0.0003683 0.004522
380 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1784 0.0003756 0.004599
381 RESPONSE TO ESTROGEN 5 218 0.0003881 0.004728
382 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 5 218 0.0003881 0.004728
383 REGULATION OF B CELL ACTIVATION 4 121 0.0003931 0.004775
384 REGULATION OF DNA METABOLIC PROCESS 6 340 0.0004039 0.004894
385 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 122 0.0004055 0.004901
386 REGULATION OF CERAMIDE BIOSYNTHETIC PROCESS 2 11 0.0004317 0.005178
387 POSITIVE REGULATION OF HAIR CYCLE 2 11 0.0004317 0.005178
388 REGULATION OF NECROPTOTIC PROCESS 2 11 0.0004317 0.005178
389 CELLULAR RESPONSE TO IONIZING RADIATION 3 52 0.0004393 0.005255
390 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 0.0004735 0.005649
391 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 6 351 0.000478 0.005688
392 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0004911 0.005784
393 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 54 0.0004911 0.005784
394 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 0.0004911 0.005784
395 B CELL RECEPTOR SIGNALING PATHWAY 3 54 0.0004911 0.005784
396 REGULATION OF VITAMIN METABOLIC PROCESS 2 12 0.0005171 0.006014
397 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.0005171 0.006014
398 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.0005171 0.006014
399 REGULATION OF B CELL PROLIFERATION 3 55 0.0005183 0.006014
400 REPLICATIVE SENESCENCE 2 12 0.0005171 0.006014
401 POSITIVE REGULATION OF EXECUTION PHASE OF APOPTOSIS 2 12 0.0005171 0.006014
402 INTERSPECIES INTERACTION BETWEEN ORGANISMS 8 662 0.0005451 0.006293
403 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 8 662 0.0005451 0.006293
404 CELL MOTILITY 9 835 0.0005486 0.006303
405 LOCALIZATION OF CELL 9 835 0.0005486 0.006303
406 MUSCLE CELL DIFFERENTIATION 5 237 0.0005679 0.006508
407 CELL PROLIFERATION 8 672 0.0006015 0.006877
408 REGULATION OF SPHINGOLIPID BIOSYNTHETIC PROCESS 2 13 0.00061 0.00689
409 REGULATION OF MEMBRANE LIPID METABOLIC PROCESS 2 13 0.00061 0.00689
410 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 2 13 0.00061 0.00689
411 PROTEIN AUTOPROCESSING 2 13 0.00061 0.00689
412 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.00061 0.00689
413 CELLULAR COMPONENT DISASSEMBLY 7 515 0.0006255 0.007048
414 ACTIVATION OF MAPK ACTIVITY 4 137 0.0006282 0.007061
415 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 5 245 0.0006598 0.007398
416 MITOTIC CELL CYCLE CHECKPOINT 4 139 0.0006633 0.007419
417 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0006693 0.007468
418 OVARIAN FOLLICLE DEVELOPMENT 3 61 0.0007025 0.00782
419 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 2 14 0.0007104 0.00787
420 DETERMINATION OF ADULT LIFESPAN 2 14 0.0007104 0.00787
421 PLATELET ACTIVATION 4 142 0.0007186 0.007942
422 NEGATIVE REGULATION OF KINASE ACTIVITY 5 250 0.0007227 0.007969
423 REGULATION OF CELL CELL ADHESION 6 380 0.0007248 0.007973
424 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 5 252 0.0007491 0.008221
425 RESPONSE TO OSMOTIC STRESS 3 63 0.000772 0.008452
426 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 5 254 0.0007762 0.008478
427 RESPONSE TO ESTRADIOL 4 146 0.0007972 0.008667
428 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 4 146 0.0007972 0.008667
429 REGULATION OF HAIR FOLLICLE DEVELOPMENT 2 15 0.0008182 0.008813
430 NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION 2 15 0.0008182 0.008813
431 NEGATIVE REGULATION OF B CELL PROLIFERATION 2 15 0.0008182 0.008813
432 NEUROTROPHIN TRK RECEPTOR SIGNALING PATHWAY 2 15 0.0008182 0.008813
433 ORGANOPHOSPHATE METABOLIC PROCESS 9 885 0.0008315 0.008936
434 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 7 541 0.0008357 0.008939
435 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 7 541 0.0008357 0.008939
436 CELL CYCLE PROCESS 10 1081 0.0008656 0.009237
437 CELLULAR RESPONSE TO UV 3 66 0.0008843 0.009415
438 GLAND DEVELOPMENT 6 395 0.0008862 0.009415
439 CELL AGING 3 67 0.0009239 0.00977
440 SINGLE ORGANISM CELLULAR LOCALIZATION 9 898 0.000922 0.00977
441 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 152 0.0009264 0.009774
442 REGULATION OF PROTEIN HOMOOLIGOMERIZATION 2 16 0.0009334 0.009804
443 REGULATION OF DEVELOPMENTAL PIGMENTATION 2 16 0.0009334 0.009804
NumGOOverlapSizeP ValueAdj. P Value
1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 10 47 7.337e-17 6.816e-14
2 DEATH RECEPTOR BINDING 7 18 3.237e-14 1.504e-11
3 CYTOKINE RECEPTOR BINDING 13 271 5.603e-13 1.735e-10
4 KINASE ACTIVITY 19 842 8.363e-13 1.942e-10
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 19 992 1.466e-11 2.724e-09
6 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 2.149e-11 3.327e-09
7 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 3.103e-11 4.119e-09
8 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 1.096e-10 1.272e-08
9 PROTEIN HETERODIMERIZATION ACTIVITY 13 468 5.125e-10 5.29e-08
10 ENZYME BINDING 22 1737 6.974e-10 6.479e-08
11 KINASE REGULATOR ACTIVITY 9 186 2.625e-09 2.217e-07
12 UBIQUITIN LIKE PROTEIN LIGASE BINDING 10 264 3.39e-09 2.594e-07
13 PROTEIN SERINE THREONINE KINASE ACTIVITY 12 445 3.63e-09 2.594e-07
14 PROTEASE BINDING 7 104 1.79e-08 1.188e-06
15 PROTEIN KINASE ACTIVITY 13 640 2.192e-08 1.272e-06
16 TUMOR NECROSIS FACTOR RECEPTOR BINDING 5 30 2.121e-08 1.272e-06
17 ADENYL NUCLEOTIDE BINDING 18 1514 1.08e-07 5.9e-06
18 RECEPTOR BINDING 17 1476 4.253e-07 2.195e-05
19 PROTEIN DIMERIZATION ACTIVITY 15 1149 5.039e-07 2.464e-05
20 DEATH RECEPTOR ACTIVITY 4 24 6.036e-07 2.804e-05
21 KINASE BINDING 11 606 9.393e-07 4.155e-05
22 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 4 30 1.537e-06 6.491e-05
23 RIBONUCLEOTIDE BINDING 18 1860 2.249e-06 8.704e-05
24 ENZYME REGULATOR ACTIVITY 13 959 2.241e-06 8.704e-05
25 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 3.563e-06 0.0001324
26 MOLECULAR FUNCTION REGULATOR 15 1353 3.888e-06 0.0001389
27 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 86 4.59e-06 0.0001579
28 PROTEIN KINASE A BINDING 4 42 6.12e-06 0.0002031
29 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 3 15 9.747e-06 0.0003018
30 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 15 9.747e-06 0.0003018
31 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 1.197e-05 0.0003588
32 IDENTICAL PROTEIN BINDING 13 1209 2.723e-05 0.0007907
33 CAMP BINDING 3 23 3.733e-05 0.001051
34 PROTEIN DOMAIN SPECIFIC BINDING 9 624 6.243e-05 0.001706
35 ENZYME INHIBITOR ACTIVITY 7 378 9.555e-05 0.002536
36 KINASE INHIBITOR ACTIVITY 4 89 0.0001209 0.003119
37 CYCLIC NUCLEOTIDE BINDING 3 36 0.0001466 0.00368
38 CYSTEINE TYPE PEPTIDASE ACTIVITY 5 184 0.0001774 0.004337
39 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 42 0.0002328 0.005546
40 SIGNAL TRANSDUCER ACTIVITY 14 1731 0.0002754 0.006288
41 PROTEIN COMPLEX BINDING 10 935 0.0002775 0.006288
42 PROTEIN PHOSPHATASE BINDING 4 120 0.0003809 0.008425
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 15 237 1.159e-16 6.77e-14
2 MEMBRANE MICRODOMAIN 14 288 5.314e-14 1.528e-11
3 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 7.852e-14 1.528e-11
4 CATALYTIC COMPLEX 20 1038 3.252e-12 4.748e-10
5 MEMBRANE PROTEIN COMPLEX 18 1020 2.203e-10 2.574e-08
6 TRANSFERASE COMPLEX 15 703 7.45e-10 7.251e-08
7 CILIARY BASE 5 23 5.084e-09 4.241e-07
8 PROTEIN KINASE COMPLEX 7 90 6.491e-09 4.739e-07
9 MEMBRANE REGION 15 1134 4.262e-07 2.765e-05
10 MITOCHONDRION 17 1633 1.743e-06 0.0001018
11 EXTRINSIC COMPONENT OF MEMBRANE 7 252 7.169e-06 0.0003806
12 PERINUCLEAR REGION OF CYTOPLASM 9 642 7.765e-05 0.003779
13 PLASMA MEMBRANE PROTEIN COMPLEX 8 510 9.327e-05 0.00419
14 PLASMA MEMBRANE RAFT 4 86 0.0001058 0.004413
15 MITOCHONDRIAL ENVELOPE 9 691 0.0001357 0.005285
16 OUTER MEMBRANE 5 190 0.0002059 0.007517

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 57 89 4.715e-145 8.487e-143
2 hsa04722_Neurotrophin_signaling_pathway 18 127 2.033e-26 1.402e-24
3 hsa04380_Osteoclast_differentiation 18 128 2.362e-26 1.402e-24
4 hsa04620_Toll.like_receptor_signaling_pathway 17 102 3.116e-26 1.402e-24
5 hsa04650_Natural_killer_cell_mediated_cytotoxicity 18 136 7.486e-26 2.653e-24
6 hsa04660_T_cell_receptor_signaling_pathway 17 108 8.844e-26 2.653e-24
7 hsa04662_B_cell_receptor_signaling_pathway 15 75 1.792e-24 4.608e-23
8 hsa04010_MAPK_signaling_pathway 20 268 1.325e-23 2.982e-22
9 hsa04910_Insulin_signaling_pathway 15 138 3.022e-20 6.044e-19
10 hsa04370_VEGF_signaling_pathway 12 76 2.253e-18 4.056e-17
11 hsa04014_Ras_signaling_pathway 16 236 3.192e-18 5.224e-17
12 hsa04062_Chemokine_signaling_pathway 15 189 3.803e-18 5.704e-17
13 hsa04914_Progesterone.mediated_oocyte_maturation 12 87 1.259e-17 1.743e-16
14 hsa04151_PI3K_AKT_signaling_pathway 17 351 7.134e-17 9.172e-16
15 hsa04973_Carbohydrate_digestion_and_absorption 9 44 4.198e-15 5.038e-14
16 hsa04510_Focal_adhesion 13 200 1.124e-14 1.265e-13
17 hsa04664_Fc_epsilon_RI_signaling_pathway 10 79 1.906e-14 2.018e-13
18 hsa04150_mTOR_signaling_pathway 9 52 2.141e-14 2.141e-13
19 hsa04115_p53_signaling_pathway 9 69 3.179e-13 3.012e-12
20 hsa04630_Jak.STAT_signaling_pathway 11 155 5.747e-13 5.173e-12
21 hsa04012_ErbB_signaling_pathway 9 87 2.767e-12 2.372e-11
22 hsa04666_Fc_gamma_R.mediated_phagocytosis 9 95 6.23e-12 5.097e-11
23 hsa04920_Adipocytokine_signaling_pathway 8 68 1.69e-11 1.323e-10
24 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 2.604e-11 1.953e-10
25 hsa04621_NOD.like_receptor_signaling_pathway 7 59 3.172e-10 2.284e-09
26 hsa04070_Phosphatidylinositol_signaling_system 7 78 2.356e-09 1.631e-08
27 hsa04670_Leukocyte_transendothelial_migration 7 117 4.061e-08 2.707e-07
28 hsa04720_Long.term_potentiation 6 70 4.657e-08 2.994e-07
29 hsa04622_RIG.I.like_receptor_signaling_pathway 6 71 5.075e-08 3.15e-07
30 hsa04310_Wnt_signaling_pathway 7 151 2.344e-07 1.406e-06
31 hsa04114_Oocyte_meiosis 6 114 8.602e-07 4.995e-06
32 hsa04810_Regulation_of_actin_cytoskeleton 7 214 2.445e-06 1.375e-05
33 hsa04020_Calcium_signaling_pathway 6 177 1.102e-05 6.009e-05
34 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.0002675 0.001416
35 hsa04742_Taste_transduction 3 52 0.0004393 0.002259
36 hsa04340_Hedgehog_signaling_pathway 3 56 0.0005466 0.002659
37 hsa04623_Cytosolic_DNA.sensing_pathway 3 56 0.0005466 0.002659
38 hsa00562_Inositol_phosphate_metabolism 3 57 0.0005758 0.002727
39 hsa04976_Bile_secretion 3 71 0.001093 0.005046
40 hsa04971_Gastric_acid_secretion 3 74 0.001233 0.005547
41 hsa04141_Protein_processing_in_endoplasmic_reticulum 4 168 0.001342 0.005891
42 hsa04970_Salivary_secretion 3 89 0.002095 0.00898
43 hsa04540_Gap_junction 3 90 0.002163 0.009055
44 hsa04912_GnRH_signaling_pathway 3 101 0.003001 0.01201
45 hsa04916_Melanogenesis 3 101 0.003001 0.01201
46 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.00443 0.01733
47 hsa04360_Axon_guidance 3 130 0.00608 0.02328
48 hsa04640_Hematopoietic_cell_lineage 2 88 0.02612 0.09796
49 hsa04110_Cell_cycle 2 128 0.05162 0.1896
50 hsa04530_Tight_junction 2 133 0.05525 0.1989
51 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.05973 0.2108
52 hsa04740_Olfactory_transduction 3 388 0.0987 0.3417

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

HCG11

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-502-3p;hsa-miR-93-5p 10 AKT3 Sponge network -0.781 0 -0.659 0.00047 0.574
2 DHRS4-AS1 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-582-5p;hsa-miR-589-3p 10 PIK3R1 Sponge network -0.646 0.01829 -0.892 0 0.557
3 LINC00261 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-188-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-629-3p 11 PIK3R1 Sponge network -1.194 0 -0.892 0 0.513
4 RP11-12A2.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -4.779 0 -0.892 0 0.489
5 LINC01018 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-93-5p 15 PIK3R1 Sponge network -3.231 0 -0.892 0 0.472
6 LDLRAD4-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 10 PIK3R1 Sponge network -3.366 0 -0.892 0 0.45
7 RP11-119D9.1 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p 11 PIK3R1 Sponge network -2.765 0 -0.892 0 0.418
8 RP11-290F5.1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p 11 PIK3R1 Sponge network -1.679 5.0E-5 -0.892 0 0.402
9 LINC00238 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 12 PIK3R1 Sponge network -4.997 0 -0.892 0 0.369
10 AC004862.6 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -2.202 0.00081 -0.892 0 0.357
11 RP11-407B7.1 hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-629-3p;hsa-miR-93-5p 10 PIK3R1 Sponge network -0.818 0.00584 -0.892 0 0.324
12 RP11-166D19.1 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-324-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p 11 PIK3R1 Sponge network -0.244 0.28835 -0.892 0 0.32
13 RP11-7F17.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p 11 PIK3R1 Sponge network -0.873 0.00204 -0.892 0 0.271
14 SMIM2-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 12 PIK3R1 Sponge network -0.66 0.00587 -0.892 0 0.27

Quest ID: c81eddd95567550d3ed8e15fc862670c