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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p AKT2 1.75 0 -0.01 0.9227 miRNAWalker2 validate -0.15 0.00352 NA
2 hsa-miR-29b-3p AKT2 -0.23 0.36746 -0.01 0.9227 MirTarget -0.14 0.00022 26512921; 26564501; 24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis
3 hsa-miR-106b-5p AKT3 1.71 0 -0.75 0.06936 miRNATAP -0.37 7.0E-5 NA
4 hsa-miR-107 AKT3 0.9 5.0E-5 -0.75 0.06936 PITA; miRanda -0.6 0 NA
5 hsa-miR-15b-5p AKT3 1.62 0 -0.75 0.06936 miRNATAP -0.36 0.00041 NA
6 hsa-miR-16-5p AKT3 1.01 1.0E-5 -0.75 0.06936 miRNAWalker2 validate; miRTarBase; miRNATAP -0.47 0.00031 NA
7 hsa-miR-17-3p AKT3 1.31 0 -0.75 0.06936 miRNATAP -0.52 0 NA
8 hsa-miR-17-5p AKT3 1.66 0 -0.75 0.06936 TargetScan; miRNATAP -0.28 0.0027 NA
9 hsa-miR-29a-3p AKT3 -0.11 0.61501 -0.75 0.06936 miRNATAP -0.41 0.00212 NA
10 hsa-miR-29b-3p AKT3 -0.23 0.36746 -0.75 0.06936 miRNATAP -0.34 0.00361 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
11 hsa-miR-32-3p AKT3 0.58 0.11837 -0.75 0.06936 mirMAP -0.32 0.00023 NA
12 hsa-miR-320b AKT3 1.11 0.0005 -0.75 0.06936 PITA; miRanda; miRNATAP -0.26 0.0039 NA
13 hsa-miR-335-3p AKT3 2.52 0 -0.75 0.06936 mirMAP -0.22 0.00074 NA
14 hsa-miR-33a-3p AKT3 0.35 0.32171 -0.75 0.06936 mirMAP -0.38 2.0E-5 NA
15 hsa-miR-362-3p AKT3 -0.03 0.91378 -0.75 0.06936 miRanda -0.38 4.0E-5 NA
16 hsa-miR-362-5p AKT3 -0.35 0.35491 -0.75 0.06936 PITA; TargetScan; miRNATAP -0.23 0.00253 NA
17 hsa-miR-501-3p AKT3 0.73 0.02704 -0.75 0.06936 miRNATAP -0.39 1.0E-5 NA
18 hsa-miR-502-3p AKT3 -0.16 0.55747 -0.75 0.06936 miRNATAP -0.5 0 NA
19 hsa-miR-505-3p AKT3 0.83 0.00112 -0.75 0.06936 mirMAP -0.35 0.00235 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
20 hsa-miR-548v AKT3 -0.16 0.70867 -0.75 0.06936 miRNATAP -0.27 0.00031 NA
21 hsa-miR-577 AKT3 0.91 0.22561 -0.75 0.06936 mirMAP -0.23 0 NA
22 hsa-miR-616-5p AKT3 0.83 0.03478 -0.75 0.06936 mirMAP -0.27 0.00041 NA
23 hsa-let-7b-5p BCL2L1 0.06 0.7814 0.21 0.39578 miRNATAP -0.31 0.00027 26915294; 20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA
24 hsa-let-7c-5p BCL2L1 -0.5 0.20685 0.21 0.39578 miRNAWalker2 validate; miRTarBase -0.2 1.0E-5 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA
25 hsa-miR-149-5p BCL2L1 0.71 0.29685 0.21 0.39578 mirMAP -0.17 0 NA
26 hsa-miR-214-3p BCL2L1 1.01 0.00625 0.21 0.39578 mirMAP -0.13 0.00824 NA
27 hsa-miR-23b-3p BCL2L1 -0.29 0.18665 0.21 0.39578 miRNAWalker2 validate -0.39 0 NA
28 hsa-let-7a-3p CBL 0.5 0.04111 0.06 0.73669 MirTarget -0.14 0.00775 NA
29 hsa-let-7b-3p CBL 0.22 0.29604 0.06 0.73669 MirTarget -0.18 0.0026 NA
30 hsa-let-7b-5p CBL 0.06 0.7814 0.06 0.73669 MirTarget -0.22 0.00034 NA
31 hsa-miR-664a-3p CBL -0.83 0.00014 0.06 0.73669 mirMAP -0.18 0.00137 NA
32 hsa-miR-330-3p CBLB 0.8 0.00747 0.2 0.34424 PITA; mirMAP -0.13 0.00804 NA
33 hsa-miR-338-3p CCND1 -0.96 0.01915 0.62 0.1312 miRNAWalker2 validate; miRTarBase; miRanda -0.24 0.00086 NA
34 hsa-let-7a-3p CCND2 0.5 0.04111 -0.5 0.3 mirMAP -0.54 0.0001 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
35 hsa-let-7b-3p CCND2 0.22 0.29604 -0.5 0.3 mirMAP -0.46 0.00588 NA
36 hsa-miR-106b-5p CCND2 1.71 0 -0.5 0.3 miRNAWalker2 validate; miRTarBase; miRNATAP -0.42 9.0E-5 NA
37 hsa-miR-130b-5p CCND2 0.7 0.05101 -0.5 0.3 mirMAP -0.39 2.0E-5 NA
38 hsa-miR-141-3p CCND2 1.46 0.00116 -0.5 0.3 MirTarget; TargetScan -0.21 0.00436 NA
39 hsa-miR-15b-5p CCND2 1.62 0 -0.5 0.3 miRNATAP -0.44 0.00021 NA
40 hsa-miR-16-2-3p CCND2 1.8 0 -0.5 0.3 mirMAP -0.55 0 NA
41 hsa-miR-16-5p CCND2 1.01 1.0E-5 -0.5 0.3 miRNAWalker2 validate; miRNATAP -0.67 1.0E-5 NA
42 hsa-miR-181a-2-3p CCND2 0.9 0.00083 -0.5 0.3 mirMAP -0.38 0.00236 NA
43 hsa-miR-182-5p CCND2 0.89 0.03106 -0.5 0.3 miRNAWalker2 validate; miRTarBase; miRNATAP -0.32 9.0E-5 NA
44 hsa-miR-183-5p CCND2 1.66 0.00052 -0.5 0.3 miRNATAP -0.29 2.0E-5 NA
45 hsa-miR-19b-3p CCND2 0.76 0.00653 -0.5 0.3 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 0.00853 NA
46 hsa-miR-21-3p CCND2 1.75 0 -0.5 0.3 mirMAP -0.33 0.0051 NA
47 hsa-miR-224-3p CCND2 1.52 0.0065 -0.5 0.3 mirMAP -0.27 4.0E-5 NA
48 hsa-miR-26b-5p CCND2 -0.3 0.16008 -0.5 0.3 mirMAP; miRNATAP -0.58 0.00034 NA
49 hsa-miR-301a-3p CCND2 1.45 1.0E-5 -0.5 0.3 miRNAWalker2 validate -0.38 0.0002 NA
50 hsa-miR-3065-3p CCND2 -1.04 0.02184 -0.5 0.3 MirTarget; miRNATAP -0.2 0.00685 NA
51 hsa-miR-3065-5p CCND2 -0.24 0.63312 -0.5 0.3 mirMAP -0.24 0.00057 NA
52 hsa-miR-424-5p CCND2 1.09 0.00042 -0.5 0.3 miRNATAP -0.39 0.0003 NA
53 hsa-miR-429 CCND2 1.4 0.009 -0.5 0.3 miRNATAP -0.19 0.002 NA
54 hsa-miR-450b-5p CCND2 0.46 0.13274 -0.5 0.3 MirTarget; PITA; miRNATAP -0.32 0.00413 NA
55 hsa-miR-590-3p CCND2 1.12 0.00016 -0.5 0.3 miRanda; mirMAP -0.33 0.00348 NA
56 hsa-miR-590-5p CCND2 1.04 0.00027 -0.5 0.3 mirMAP -0.41 0.00055 NA
57 hsa-miR-9-3p CCND2 0.33 0.54111 -0.5 0.3 MirTarget; mirMAP; miRNATAP -0.19 0.00361 NA
58 hsa-miR-93-5p CCND2 1.75 0 -0.5 0.3 miRNATAP -0.32 0.00244 NA
59 hsa-miR-96-5p CCND2 1.14 0.00943 -0.5 0.3 TargetScan; miRNATAP -0.33 3.0E-5 NA
60 hsa-miR-96-5p CCND3 1.14 0.00943 0.04 0.88352 TargetScan -0.12 0.00328 NA
61 hsa-miR-214-5p CISH 1.03 0.00141 -0.74 0.00068 miRNATAP -0.14 0.00445 NA
62 hsa-miR-24-3p CISH 1.09 0 -0.74 0.00068 MirTarget -0.26 0.00016 NA
63 hsa-miR-324-5p CISH 1.09 3.0E-5 -0.74 0.00068 miRanda -0.2 0.00066 NA
64 hsa-miR-374a-3p CISH 0.04 0.85148 -0.74 0.00068 MirTarget -0.21 0.00334 NA
65 hsa-miR-429 CLCF1 1.4 0.009 0.06 0.86548 miRanda; miRNATAP -0.12 0.00902 NA
66 hsa-miR-491-5p CLCF1 -0.69 0.03136 0.06 0.86548 miRanda -0.22 0.00471 NA
67 hsa-miR-19a-3p CNTFR 1.27 0.00011 -3.87 2.0E-5 miRNATAP -0.51 0.00932 NA
68 hsa-miR-200b-3p CNTFR 0.97 0.0595 -3.87 2.0E-5 TargetScan -0.38 0.00252 NA
69 hsa-miR-21-5p CNTFR 1.75 0 -3.87 2.0E-5 miRNATAP -1.42 2.0E-5 NA
70 hsa-miR-429 CNTFR 1.4 0.009 -3.87 2.0E-5 PITA; miRanda; miRNATAP -0.41 0.00074 NA
71 hsa-miR-186-5p CREBBP 0.15 0.43471 -0.11 0.45436 mirMAP; miRNATAP -0.14 0.00768 NA
72 hsa-miR-429 CSF2RA 1.4 0.009 1.26 0.0032 miRanda -0.18 0.00171 NA
73 hsa-miR-15b-3p CSF2RB 1.76 0 -0.2 0.59657 mirMAP -0.31 0.00012 NA
74 hsa-miR-30b-3p CSF2RB -0.27 0.40085 -0.2 0.59657 MirTarget -0.25 0.00393 NA
75 hsa-miR-452-3p CSF2RB 2.2 0.00185 -0.2 0.59657 mirMAP -0.13 0.00156 NA
76 hsa-miR-940 CSF3R 1.64 0.00069 0.65 0.1766 MirTarget -0.25 0.00251 NA
77 hsa-miR-185-5p CTF1 1.14 0 -1.12 0.01655 MirTarget -0.45 0.00646 NA
78 hsa-miR-590-3p CTF1 1.12 0.00016 -1.12 0.01655 miRanda -0.43 0.00011 NA
79 hsa-miR-106b-5p EP300 1.71 0 0.03 0.83304 miRNATAP -0.1 0.00164 NA
80 hsa-miR-212-3p EP300 0.96 0.00133 0.03 0.83304 MirTarget; miRNATAP -0.12 0.00033 NA
81 hsa-miR-26a-5p EP300 -0.38 0.04425 0.03 0.83304 miRNATAP -0.19 0.00038 NA
82 hsa-miR-26b-5p EP300 -0.3 0.16008 0.03 0.83304 miRNAWalker2 validate; miRNATAP -0.14 0.00299 NA
83 hsa-miR-326 EPO -0.43 0.26299 0.93 0.19366 miRanda -0.49 0.00021 NA
84 hsa-miR-338-3p EPO -0.96 0.01915 0.93 0.19366 miRanda -0.65 0 NA
85 hsa-miR-362-3p EPO -0.03 0.91378 0.93 0.19366 miRanda -0.59 0.00017 NA
86 hsa-let-7g-5p GHR 0.33 0.24114 -2.84 0 miRNATAP -0.44 0.00553 NA
87 hsa-miR-126-5p GHR 0.42 0.07532 -2.84 0 MirTarget; mirMAP -0.53 0.00576 NA
88 hsa-miR-142-3p GHR 1.32 0.00015 -2.84 0 MirTarget; PITA; miRanda; miRNATAP -0.32 0.00955 NA
89 hsa-miR-15a-5p GHR 1.04 0 -2.84 0 MirTarget; miRNATAP -0.72 0.00052 NA
90 hsa-miR-15b-5p GHR 1.62 0 -2.84 0 MirTarget; miRNATAP -0.53 0.00053 NA
91 hsa-miR-16-2-3p GHR 1.8 0 -2.84 0 mirMAP -0.46 0.00099 NA
92 hsa-miR-16-5p GHR 1.01 1.0E-5 -2.84 0 MirTarget; miRNATAP -0.7 0.00039 NA
93 hsa-miR-29a-5p GHR 0.59 0.02301 -2.84 0 mirMAP; miRNATAP -0.97 0 NA
94 hsa-miR-338-5p GHR -1.2 0.01003 -2.84 0 PITA -0.47 0 NA
95 hsa-miR-421 GHR 1.81 0 -2.84 0 miRanda -0.41 0.00104 NA
96 hsa-miR-429 GHR 1.4 0.009 -2.84 0 miRanda; miRNATAP -0.37 0 NA
97 hsa-miR-624-5p GHR 1.03 0.00109 -2.84 0 MirTarget -0.38 0.00873 NA
98 hsa-miR-7-1-3p GHR 0.71 0.04123 -2.84 0 MirTarget; mirMAP -0.75 0 NA
99 hsa-miR-17-3p IFNAR1 1.31 0 -0.54 0.00028 mirMAP -0.15 0.00012 NA
100 hsa-miR-320b IFNAR1 1.11 0.0005 -0.54 0.00028 mirMAP -0.12 0.00035 NA
101 hsa-miR-361-5p IFNAR1 0.41 0.01813 -0.54 0.00028 miRanda -0.24 0.00015 NA
102 hsa-miR-3913-5p IFNAR1 0.88 0.0031 -0.54 0.00028 mirMAP -0.11 0.00237 NA
103 hsa-miR-452-5p IFNAR1 2.09 0.00026 -0.54 0.00028 mirMAP -0.11 0 NA
104 hsa-miR-484 IFNAR1 0.71 0.00234 -0.54 0.00028 miRNATAP -0.14 0.00148 NA
105 hsa-miR-1271-5p IFNAR2 1.16 0.00208 0.46 0.01429 mirMAP -0.15 3.0E-5 NA
106 hsa-miR-224-3p IFNAR2 1.52 0.0065 0.46 0.01429 mirMAP -0.14 0 NA
107 hsa-miR-129-5p IFNGR1 -2.57 0 0.65 0.00245 miRanda -0.11 3.0E-5 NA
108 hsa-miR-330-5p IL11RA 0.49 0.05122 -1.58 0 miRanda -0.29 0.0015 NA
109 hsa-miR-338-3p IL12RB2 -0.96 0.01915 1.56 0.02217 miRanda -0.54 0 NA
110 hsa-miR-625-5p IL12RB2 0.54 0.2038 1.56 0.02217 miRNAWalker2 validate -0.54 0 NA
111 hsa-miR-7-5p IL12RB2 1.64 0.01244 1.56 0.02217 miRNAWalker2 validate -0.23 0.00317 NA
112 hsa-miR-128-3p IL13RA1 0.98 6.0E-5 -0.09 0.65684 MirTarget -0.2 0.00068 NA
113 hsa-miR-16-2-3p IL13RA1 1.8 0 -0.09 0.65684 MirTarget -0.17 0.00021 NA
114 hsa-miR-181a-2-3p IL13RA1 0.9 0.00083 -0.09 0.65684 MirTarget -0.15 0.00559 NA
115 hsa-miR-22-3p IL13RA1 0.03 0.84509 -0.09 0.65684 MirTarget; miRNATAP -0.25 0.00795 NA
116 hsa-miR-224-3p IL13RA1 1.52 0.0065 -0.09 0.65684 MirTarget -0.12 2.0E-5 NA
117 hsa-miR-324-5p IL13RA1 1.09 3.0E-5 -0.09 0.65684 miRanda -0.19 0.0005 NA
118 hsa-miR-331-3p IL13RA1 1.05 0.0001 -0.09 0.65684 MirTarget -0.16 0.00261 NA
119 hsa-miR-590-3p IL13RA1 1.12 0.00016 -0.09 0.65684 miRanda; mirMAP -0.13 0.0059 NA
120 hsa-miR-129-5p IL15 -2.57 0 0.56 0.11436 miRanda -0.13 0.00483 NA
121 hsa-miR-429 IL15 1.4 0.009 0.56 0.11436 miRanda -0.13 0.00588 NA
122 hsa-miR-199b-5p IL15RA 0.12 0.67816 0.75 0.0055 miRanda -0.18 0.00608 NA
123 hsa-miR-107 IL20 0.9 5.0E-5 2.15 0.0113 miRanda -1.07 8.0E-5 NA
124 hsa-miR-125a-5p IL22RA1 -0.88 0.00021 1.79 0.00031 miRanda -0.46 0.00253 NA
125 hsa-miR-3065-3p IL2RA -1.04 0.02184 1.59 0.0009 MirTarget -0.3 5.0E-5 NA
126 hsa-miR-375 IL2RA -2.95 0.0057 1.59 0.0009 miRanda -0.11 0.00044 NA
127 hsa-miR-30b-3p IL2RB -0.27 0.40085 1.39 0.0004 mirMAP -0.25 0.00526 NA
128 hsa-miR-429 IL4R 1.4 0.009 0 0.98645 miRNATAP -0.13 5.0E-5 NA
129 hsa-miR-335-5p IL6 1.6 6.0E-5 -0.23 0.73147 miRNAWalker2 validate -0.51 2.0E-5 NA
130 hsa-miR-429 IL6 1.4 0.009 -0.23 0.73147 miRanda -0.44 0 NA
131 hsa-miR-106b-5p IL6R 1.71 0 -0.91 0.00927 mirMAP -0.38 0 NA
132 hsa-miR-130b-3p IL6R 1.33 5.0E-5 -0.91 0.00927 mirMAP -0.25 0.00074 NA
133 hsa-miR-135b-5p IL6R 4.09 0 -0.91 0.00927 mirMAP -0.15 0.00016 NA
134 hsa-miR-17-5p IL6R 1.66 0 -0.91 0.00927 mirMAP -0.29 0.00016 NA
135 hsa-miR-182-5p IL6R 0.89 0.03106 -0.91 0.00927 mirMAP -0.18 0.00277 NA
136 hsa-miR-197-3p IL6R 0.89 0.0002 -0.91 0.00927 MirTarget -0.3 0.00341 NA
137 hsa-miR-20a-5p IL6R 1.45 0 -0.91 0.00927 mirMAP -0.28 0.00088 NA
138 hsa-miR-320b IL6R 1.11 0.0005 -0.91 0.00927 miRanda; miRNATAP -0.26 0.00071 NA
139 hsa-miR-320c IL6R 0.46 0.24061 -0.91 0.00927 miRanda; miRNATAP -0.27 0.00034 NA
140 hsa-miR-335-5p IL6R 1.6 6.0E-5 -0.91 0.00927 mirMAP -0.24 0.00012 NA
141 hsa-miR-484 IL6R 0.71 0.00234 -0.91 0.00927 MirTarget -0.28 0.00947 NA
142 hsa-miR-93-5p IL6R 1.75 0 -0.91 0.00927 mirMAP -0.28 0.00026 NA
143 hsa-let-7a-3p IL6ST 0.5 0.04111 -1.43 0 mirMAP -0.25 0.00799 NA
144 hsa-let-7f-1-3p IL6ST 1.29 0 -1.43 0 mirMAP -0.36 1.0E-5 NA
145 hsa-miR-103a-3p IL6ST 0.84 0 -1.43 0 mirMAP -0.67 0 NA
146 hsa-miR-1301-3p IL6ST 1.59 0 -1.43 0 MirTarget -0.29 1.0E-5 NA
147 hsa-miR-130b-3p IL6ST 1.33 5.0E-5 -1.43 0 miRNATAP -0.39 0 NA
148 hsa-miR-135b-5p IL6ST 4.09 0 -1.43 0 mirMAP -0.11 0.00179 NA
149 hsa-miR-148b-3p IL6ST 0.3 0.17466 -1.43 0 MirTarget -0.28 0.00764 NA
150 hsa-miR-148b-5p IL6ST 1.04 0.00196 -1.43 0 mirMAP -0.2 0.00278 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE MEDIATED SIGNALING PATHWAY 40 452 6.232e-45 2.9e-41
2 RESPONSE TO CYTOKINE 44 714 5.697e-43 1.325e-39
3 CELLULAR RESPONSE TO CYTOKINE STIMULUS 40 606 9.079e-40 1.408e-36
4 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 55 1848 7.645e-39 8.893e-36
5 STAT CASCADE 18 50 1.115e-31 8.645e-29
6 JAK STAT CASCADE 18 50 1.115e-31 8.645e-29
7 INTRACELLULAR SIGNAL TRANSDUCTION 39 1572 1.287e-22 8.556e-20
8 REGULATION OF JAK STAT CASCADE 18 144 1.717e-22 8.879e-20
9 REGULATION OF STAT CASCADE 18 144 1.717e-22 8.879e-20
10 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 12 37 1.03e-20 4.793e-18
11 POSITIVE REGULATION OF STAT CASCADE 14 73 2.055e-20 7.968e-18
12 POSITIVE REGULATION OF JAK STAT CASCADE 14 73 2.055e-20 7.968e-18
13 REGULATION OF IMMUNE SYSTEM PROCESS 35 1403 4.304e-20 1.431e-17
14 REGULATION OF PHOSPHORUS METABOLIC PROCESS 37 1618 4.269e-20 1.431e-17
15 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 37 1656 9.352e-20 2.901e-17
16 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 12 44 1.148e-19 3.337e-17
17 POSITIVE REGULATION OF RESPONSE TO STIMULUS 39 1929 1.925e-19 5.268e-17
18 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN 13 68 5.335e-19 1.379e-16
19 REGULATION OF IMMUNE RESPONSE 28 858 7.825e-19 1.916e-16
20 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 9 20 2.371e-17 5.253e-15
21 REGULATION OF PROTEIN MODIFICATION PROCESS 35 1710 2.33e-17 5.253e-15
22 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 24 689 1.005e-16 2.125e-14
23 REGULATION OF KINASE ACTIVITY 25 776 1.236e-16 2.5e-14
24 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 16 213 1.854e-16 3.594e-14
25 IMMUNE SYSTEM PROCESS 36 1984 3.075e-16 5.504e-14
26 RESPONSE TO HORMONE 26 893 2.989e-16 5.504e-14
27 PHOSPHORYLATION 29 1228 8.822e-16 1.52e-13
28 RESPONSE TO GROWTH HORMONE 9 30 1.957e-15 3.251e-13
29 POSITIVE REGULATION OF CELL ACTIVATION 17 311 3.934e-15 6.102e-13
30 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 20 498 3.92e-15 6.102e-13
31 REGULATION OF TRANSFERASE ACTIVITY 25 946 1.186e-14 1.78e-12
32 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 24 867 1.668e-14 2.426e-12
33 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 30 1492 1.761e-14 2.483e-12
34 NEGATIVE REGULATION OF CELL DEATH 24 872 1.893e-14 2.59e-12
35 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 24 876 2.092e-14 2.782e-12
36 POSITIVE REGULATION OF CELL PROLIFERATION 23 814 4.335e-14 5.603e-12
37 CELL ACTIVATION 20 568 4.668e-14 5.87e-12
38 RESPONSE TO ENDOGENOUS STIMULUS 29 1450 6.493e-14 7.875e-12
39 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 13 162 6.601e-14 7.875e-12
40 JAK STAT CASCADE INVOLVED IN GROWTH HORMONE SIGNALING PATHWAY 7 15 7.169e-14 8.34e-12
41 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 26 1135 8.637e-14 9.802e-12
42 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 25 1036 9.262e-14 1.002e-11
43 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1036 9.262e-14 1.002e-11
44 PROTEIN PHOSPHORYLATION 24 944 1.068e-13 1.129e-11
45 REGULATION OF CELL PROLIFERATION 29 1496 1.438e-13 1.487e-11
46 RESPONSE TO PEPTIDE 17 404 2.828e-13 2.861e-11
47 LYMPHOCYTE ACTIVATION 16 342 3.065e-13 3.034e-11
48 CELLULAR RESPONSE TO HORMONE STIMULUS 19 552 3.333e-13 3.231e-11
49 REGULATION OF LEUKOCYTE DIFFERENTIATION 14 232 3.441e-13 3.268e-11
50 REGULATION OF CELL ACTIVATION 18 484 4.181e-13 3.891e-11
51 POSITIVE REGULATION OF CELL CELL ADHESION 14 243 6.482e-13 5.914e-11
52 REGULATION OF CELL DEATH 28 1472 6.993e-13 6.257e-11
53 CELLULAR RESPONSE TO NITROGEN COMPOUND 18 505 8.555e-13 7.511e-11
54 REGULATION OF CELL DIFFERENTIATION 28 1492 9.713e-13 8.295e-11
55 REGULATION OF HOMOTYPIC CELL CELL ADHESION 15 307 9.805e-13 8.295e-11
56 RESPONSE TO OXYGEN CONTAINING COMPOUND 27 1381 1.089e-12 9.051e-11
57 RESPONSE TO NITROGEN COMPOUND 22 859 1.242e-12 1.014e-10
58 REGULATION OF HEMOPOIESIS 15 314 1.357e-12 1.088e-10
59 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 27 1395 1.381e-12 1.089e-10
60 REGULATION OF CELL CELL ADHESION 16 380 1.529e-12 1.186e-10
61 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 21 799 2.756e-12 2.102e-10
62 CELLULAR RESPONSE TO PEPTIDE 14 274 3.308e-12 2.483e-10
63 LEUKOCYTE ACTIVATION 16 414 5.586e-12 4.125e-10
64 PEPTIDYL TYROSINE MODIFICATION 12 186 8.719e-12 6.339e-10
65 POSITIVE REGULATION OF CELL COMMUNICATION 27 1532 1.227e-11 8.785e-10
66 REGULATION OF T CELL DIFFERENTIATION 10 107 1.325e-11 9.342e-10
67 POSITIVE REGULATION OF CELL ADHESION 15 376 1.775e-11 1.233e-09
68 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 30 1977 2.52e-11 1.725e-09
69 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 22 1008 2.858e-11 1.927e-09
70 REGULATION OF CELL ADHESION 18 629 3.28e-11 2.18e-09
71 LYMPHOCYTE DIFFERENTIATION 12 209 3.425e-11 2.244e-09
72 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 25 1360 3.677e-11 2.376e-09
73 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 23 1142 4.559e-11 2.906e-09
74 POSITIVE REGULATION OF MOLECULAR FUNCTION 28 1791 7.613e-11 4.787e-09
75 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 8 59 7.765e-11 4.818e-09
76 REGULATION OF DEFENSE RESPONSE 19 759 8.405e-11 5.146e-09
77 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 10 131 1.009e-10 6.094e-09
78 REGULATION OF LYMPHOCYTE DIFFERENTIATION 10 132 1.088e-10 6.489e-09
79 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 10 144 2.576e-10 1.517e-08
80 POSITIVE REGULATION OF CATALYTIC ACTIVITY 25 1518 3.79e-10 2.204e-08
81 PEPTIDYL AMINO ACID MODIFICATION 19 841 4.74e-10 2.723e-08
82 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 26 1672 5.198e-10 2.95e-08
83 POSITIVE REGULATION OF IMMUNE RESPONSE 16 563 5.268e-10 2.953e-08
84 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 5 12 6.554e-10 3.63e-08
85 NEGATIVE REGULATION OF CELL COMMUNICATION 22 1192 6.997e-10 3.83e-08
86 CELL PROLIFERATION 17 672 8.31e-10 4.496e-08
87 IMMUNE SYSTEM DEVELOPMENT 16 582 8.518e-10 4.545e-08
88 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 8.597e-10 4.545e-08
89 POSITIVE REGULATION OF HEMOPOIESIS 10 163 8.703e-10 4.55e-08
90 POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 8 80 9.499e-10 4.911e-08
91 REGULATION OF RESPONSE TO STRESS 24 1468 1.102e-09 5.633e-08
92 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 14 437 1.568e-09 7.933e-08
93 LEUKOCYTE DIFFERENTIATION 12 292 1.604e-09 8.026e-08
94 HOMEOSTASIS OF NUMBER OF CELLS 10 175 1.739e-09 8.608e-08
95 POSITIVE REGULATION OF CYTOKINE PRODUCTION 13 370 2.114e-09 1.035e-07
96 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 9 136 3.275e-09 1.587e-07
97 REGULATION OF CYTOKINE PRODUCTION 15 563 4.7e-09 2.254e-07
98 LEUKOCYTE CELL CELL ADHESION 11 255 4.908e-09 2.33e-07
99 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 5 17 5.042e-09 2.37e-07
100 LEUKOCYTE MIGRATION 11 259 5.772e-09 2.686e-07
101 REGULATION OF LEUKOCYTE PROLIFERATION 10 206 8.386e-09 3.863e-07
102 REGULATION OF TYPE I INTERFERON MEDIATED SIGNALING PATHWAY 6 39 9.207e-09 4.2e-07
103 NEGATIVE REGULATION OF PHOSPHORYLATION 13 422 1.021e-08 4.611e-07
104 RESPONSE TO ORGANIC CYCLIC COMPOUND 18 917 1.329e-08 5.945e-07
105 REGULATION OF INNATE IMMUNE RESPONSE 12 357 1.523e-08 6.751e-07
106 POSITIVE REGULATION OF CELL DIFFERENTIATION 17 823 1.717e-08 7.536e-07
107 RESPONSE TO ALCOHOL 12 362 1.777e-08 7.726e-07
108 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 6 44 1.961e-08 8.449e-07
109 REGULATION OF RESPONSE TO INTERFERON GAMMA 5 22 2.113e-08 9.019e-07
110 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 2.426e-08 1.026e-06
111 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 23 2.691e-08 1.128e-06
112 T CELL DIFFERENTIATION 8 123 2.946e-08 1.224e-06
113 REGULATION OF ERBB SIGNALING PATHWAY 7 83 3.732e-08 1.537e-06
114 IMMUNE RESPONSE 19 1100 3.788e-08 1.546e-06
115 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 4.224e-08 1.709e-06
116 TYROSINE PHOSPHORYLATION OF STAT PROTEIN 4 10 4.65e-08 1.865e-06
117 POSITIVE REGULATION OF KINASE ACTIVITY 13 482 4.882e-08 1.942e-06
118 RESPONSE TO LIPID 17 888 5.197e-08 2.049e-06
119 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 138 7.237e-08 2.83e-06
120 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 55 7.781e-08 3.017e-06
121 POSITIVE REGULATION OF T CELL PROLIFERATION 7 95 9.565e-08 3.678e-06
122 REGULATION OF T CELL PROLIFERATION 8 147 1.181e-07 4.504e-06
123 LIPID PHOSPHORYLATION 7 99 1.272e-07 4.814e-06
124 HOMEOSTATIC PROCESS 20 1337 1.631e-07 6.121e-06
125 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 13 541 1.856e-07 6.853e-06
126 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 13 541 1.856e-07 6.853e-06
127 RESPONSE TO ESTROGEN 9 218 1.957e-07 7.17e-06
128 DEFENSE RESPONSE 19 1231 2.208e-07 8.027e-06
129 SINGLE ORGANISM CELL ADHESION 12 459 2.355e-07 8.433e-06
130 REGULATION OF MULTICELLULAR ORGANISM GROWTH 6 66 2.356e-07 8.433e-06
131 REGULATION OF INFLAMMATORY RESPONSE 10 294 2.382e-07 8.459e-06
132 REGULATION OF MAPK CASCADE 14 660 2.716e-07 9.575e-06
133 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 12 470 3.033e-07 1.061e-05
134 RESPONSE TO EXTERNAL STIMULUS 23 1821 3.241e-07 1.126e-05
135 GLUCOSE HOMEOSTASIS 8 170 3.608e-07 1.234e-05
136 CARBOHYDRATE HOMEOSTASIS 8 170 3.608e-07 1.234e-05
137 NEGATIVE REGULATION OF NEURON DEATH 8 171 3.773e-07 1.282e-05
138 MAMMARY GLAND DEVELOPMENT 7 117 4.005e-07 1.35e-05
139 IMMUNE EFFECTOR PROCESS 12 486 4.332e-07 1.45e-05
140 RESPONSE TO STEROID HORMONE 12 497 5.491e-07 1.825e-05
141 REGULATION OF ADAPTIVE IMMUNE RESPONSE 7 123 5.628e-07 1.857e-05
142 POSITIVE REGULATION OF GENE EXPRESSION 22 1733 5.81e-07 1.904e-05
143 INOSITOL LIPID MEDIATED SIGNALING 7 124 5.946e-07 1.935e-05
144 NEGATIVE REGULATION OF KINASE ACTIVITY 9 250 6.199e-07 2.003e-05
145 POSITIVE REGULATION OF GLUCOSE TRANSPORT 5 42 6.417e-07 2.059e-05
146 ERBB SIGNALING PATHWAY 6 79 6.921e-07 2.206e-05
147 CELL CELL ADHESION 13 608 6.98e-07 2.209e-05
148 ACUTE PHASE RESPONSE 5 43 7.239e-07 2.276e-05
149 INSULIN RECEPTOR SIGNALING PATHWAY 6 80 7.459e-07 2.329e-05
150 CELL MOTILITY 15 835 7.999e-07 2.444e-05
151 LOCALIZATION OF CELL 15 835 7.999e-07 2.444e-05
152 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 13 616 8.083e-07 2.444e-05
153 NEGATIVE REGULATION OF JAK STAT CASCADE 5 44 8.142e-07 2.444e-05
154 NEGATIVE REGULATION OF STAT CASCADE 5 44 8.142e-07 2.444e-05
155 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 616 8.083e-07 2.444e-05
156 NEGATIVE REGULATION OF MOLECULAR FUNCTION 17 1079 8.198e-07 2.445e-05
157 REGULATION OF IMMUNE EFFECTOR PROCESS 11 424 8.458e-07 2.507e-05
158 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 17 1087 9.08e-07 2.674e-05
159 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 9.448e-07 2.765e-05
160 REGULATION OF GROWTH 13 633 1.096e-06 3.186e-05
161 RESPONSE TO INSULIN 8 205 1.487e-06 4.296e-05
162 CELLULAR RESPONSE TO INTERLEUKIN 6 4 22 1.562e-06 4.487e-05
163 RESPONSE TO BIOTIC STIMULUS 15 886 1.675e-06 4.78e-05
164 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 1.845e-06 5.233e-05
165 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 289 2.061e-06 5.811e-05
166 MAMMARY GLAND EPITHELIUM DEVELOPMENT 5 53 2.093e-06 5.865e-05
167 REGULATION OF GTPASE ACTIVITY 13 673 2.16e-06 6.019e-05
168 REGULATION OF HYDROLASE ACTIVITY 18 1327 3.141e-06 8.585e-05
169 REGULATION OF TYPE 2 IMMUNE RESPONSE 4 26 3.155e-06 8.585e-05
170 REGULATION OF T HELPER CELL DIFFERENTIATION 4 26 3.155e-06 8.585e-05
171 RESPONSE TO INTERLEUKIN 6 4 26 3.155e-06 8.585e-05
172 GLAND DEVELOPMENT 10 395 3.452e-06 9.338e-05
173 REGULATION OF GLUCOSE IMPORT 5 60 3.897e-06 0.0001042
174 LEUKOCYTE HOMEOSTASIS 5 60 3.897e-06 0.0001042
175 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 4.104e-06 0.0001091
176 POSITIVE REGULATION OF ACTIVATED T CELL PROLIFERATION 4 28 4.295e-06 0.0001136
177 REGULATION OF BODY FLUID LEVELS 11 506 4.665e-06 0.0001226
178 GROWTH 10 410 4.799e-06 0.0001254
179 REGULATION OF RESPONSE TO WOUNDING 10 413 5.117e-06 0.000133
180 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 6 113 5.656e-06 0.0001462
181 RESPONSE TO INTERLEUKIN 4 4 31 6.541e-06 0.0001672
182 POSITIVE REGULATION OF IMMUNOGLOBULIN PRODUCTION 4 31 6.541e-06 0.0001672
183 REGULATION OF NEURON DEATH 8 252 6.857e-06 0.0001743
184 RESPONSE TO TYPE I INTERFERON 5 68 7.258e-06 0.0001835
185 RESPONSE TO KETONE 7 182 7.683e-06 0.0001932
186 NEGATIVE REGULATION OF IMMUNE RESPONSE 6 121 8.391e-06 0.0002099
187 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 8.798e-06 0.0002189
188 OXALOACETATE METABOLIC PROCESS 3 11 9.567e-06 0.0002343
189 CREATINE METABOLIC PROCESS 3 11 9.567e-06 0.0002343
190 REGULATION OF T HELPER 2 CELL DIFFERENTIATION 3 11 9.567e-06 0.0002343
191 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 9 351 9.957e-06 0.0002426
192 ACUTE INFLAMMATORY RESPONSE 5 73 1.03e-05 0.0002496
193 NEGATIVE REGULATION OF HEMOPOIESIS 6 128 1.159e-05 0.0002793
194 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 129 1.211e-05 0.000289
195 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 36 1.206e-05 0.000289
196 NATURAL KILLER CELL DIFFERENTIATION 3 12 1.272e-05 0.0002989
197 NEGATIVE REGULATION OF CD4 POSITIVE ALPHA BETA T CELL DIFFERENTIATION 3 12 1.272e-05 0.0002989
198 POSITIVE REGULATION OF ASTROCYTE DIFFERENTIATION 3 12 1.272e-05 0.0002989
199 B CELL ACTIVATION 6 132 1.381e-05 0.000323
200 REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 4 38 1.503e-05 0.0003496
201 POSITIVE REGULATION OF MAPK CASCADE 10 470 1.578e-05 0.0003642
202 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 9 372 1.581e-05 0.0003642
203 POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 13 1.649e-05 0.0003761
204 ENERGY HOMEOSTASIS 3 13 1.649e-05 0.0003761
205 EMBRYO IMPLANTATION 4 39 1.669e-05 0.0003789
206 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 5 82 1.82e-05 0.000411
207 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 1.849e-05 0.0004122
208 REGULATION OF DEVELOPMENTAL GROWTH 8 289 1.852e-05 0.0004122
209 REGULATION OF ACTIVATED T CELL PROLIFERATION 4 40 1.849e-05 0.0004122
210 LIPID MODIFICATION 7 210 1.946e-05 0.0004311
211 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 13 829 2.036e-05 0.0004484
212 LACTATION 4 41 2.043e-05 0.0004484
213 PLATELET ACTIVATION 6 142 2.092e-05 0.000457
214 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 296 2.198e-05 0.000478
215 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 2.252e-05 0.0004874
216 POSITIVE REGULATION OF B CELL ACTIVATION 5 86 2.294e-05 0.0004942
217 NEGATIVE REGULATION OF MAPK CASCADE 6 145 2.355e-05 0.0005049
218 RESPONSE TO ESTRADIOL 6 146 2.448e-05 0.0005201
219 CELLULAR RESPONSE TO INSULIN STIMULUS 6 146 2.448e-05 0.0005201
220 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 88 2.565e-05 0.0005424
221 T CELL LINEAGE COMMITMENT 3 15 2.608e-05 0.0005442
222 NEGATIVE REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 3 15 2.608e-05 0.0005442
223 NEGATIVE REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 3 15 2.608e-05 0.0005442
224 LOCOMOTION 15 1114 2.623e-05 0.0005449
225 NEGATIVE REGULATION OF CELL ADHESION 7 223 2.861e-05 0.0005916
226 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 9 404 3.026e-05 0.0006229
227 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 16 1275 3.203e-05 0.0006536
228 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 3 16 3.201e-05 0.0006536
229 REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 4 46 3.243e-05 0.000659
230 CHEMICAL HOMEOSTASIS 13 874 3.531e-05 0.0007068
231 REGULATION OF IMMUNOGLOBULIN PRODUCTION 4 47 3.534e-05 0.0007068
232 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 6 156 3.555e-05 0.0007068
233 POSITIVE REGULATION OF IMMUNE EFFECTOR PROCESS 6 156 3.555e-05 0.0007068
234 RESPONSE TO ANTIBIOTIC 4 47 3.534e-05 0.0007068
235 REGULATION OF MAP KINASE ACTIVITY 8 319 3.745e-05 0.0007416
236 HORMONE MEDIATED SIGNALING PATHWAY 6 158 3.818e-05 0.0007527
237 REGULATION OF LIPID KINASE ACTIVITY 4 48 3.844e-05 0.0007547
238 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 8 323 4.091e-05 0.0007997
239 REGULATION OF ERK1 AND ERK2 CASCADE 7 238 4.33e-05 0.000843
240 POSITIVE REGULATION OF RESPONSE TO WOUNDING 6 162 4.391e-05 0.0008514
241 MYELOID LEUKOCYTE MIGRATION 5 99 4.527e-05 0.0008704
242 LYMPHOCYTE HOMEOSTASIS 4 50 4.523e-05 0.0008704
243 POSITIVE REGULATION OF T HELPER CELL DIFFERENTIATION 3 18 4.638e-05 0.000888
244 BIOLOGICAL ADHESION 14 1032 4.676e-05 0.0008916
245 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 100 4.75e-05 0.0008985
246 REGULATION OF GLUCOSE TRANSPORT 5 100 4.75e-05 0.0008985
247 POSITIVE REGULATION OF CELL CYCLE 8 332 4.965e-05 0.0009348
248 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 5 101 4.982e-05 0.0009348
249 POSITIVE REGULATION OF HYDROLASE ACTIVITY 13 905 5.054e-05 0.0009444
250 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 5 102 5.223e-05 0.0009721
251 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 4 52 5.285e-05 0.0009797
252 RESPONSE TO VIRUS 7 247 5.476e-05 0.001011
253 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 5.732e-05 0.001054
254 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 13 926 6.387e-05 0.001166
255 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 3 20 6.442e-05 0.001166
256 X2 OXOGLUTARATE METABOLIC PROCESS 3 20 6.442e-05 0.001166
257 RESPONSE TO LEPTIN 3 20 6.442e-05 0.001166
258 NATURAL KILLER CELL ACTIVATION 4 55 6.598e-05 0.00119
259 POSITIVE REGULATION OF TRANSPORT 13 936 7.123e-05 0.00128
260 INFLAMMATORY RESPONSE 9 454 7.454e-05 0.001334
261 REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 21 7.495e-05 0.001336
262 EPITHELIUM DEVELOPMENT 13 945 7.847e-05 0.001394
263 GLYCEROLIPID METABOLIC PROCESS 8 356 8.091e-05 0.001431
264 REGULATION OF CELL CYCLE 13 949 8.189e-05 0.001443
265 REGULATION OF MYELOID CELL DIFFERENTIATION 6 183 8.639e-05 0.001514
266 REGULATION OF T HELPER 1 TYPE IMMUNE RESPONSE 3 22 8.653e-05 0.001514
267 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 9 465 8.947e-05 0.001559
268 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 60 9.294e-05 0.001614
269 PHOSPHOLIPID METABOLIC PROCESS 8 364 9.44e-05 0.001627
270 POSITIVE REGULATION OF DEFENSE RESPONSE 8 364 9.44e-05 0.001627
271 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 9.917e-05 0.001685
272 REGULATION OF METANEPHROS DEVELOPMENT 3 23 9.923e-05 0.001685
273 BRANCHED CHAIN AMINO ACID METABOLIC PROCESS 3 23 9.923e-05 0.001685
274 NEGATIVE REGULATION OF ALPHA BETA T CELL ACTIVATION 3 23 9.923e-05 0.001685
275 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 118 0.0001045 0.001767
276 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 5 121 0.0001176 0.001961
277 REGULATION OF B CELL ACTIVATION 5 121 0.0001176 0.001961
278 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 0.0001173 0.001961
279 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 983 0.0001166 0.001961
280 POSITIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 64 0.0001197 0.001989
281 REGULATION OF CHEMOKINE PRODUCTION 4 65 0.0001271 0.002098
282 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 4 65 0.0001271 0.002098
283 CELLULAR RESPONSE TO UV 4 66 0.0001349 0.002218
284 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 0.0001385 0.00227
285 RESPONSE TO UV 5 126 0.0001423 0.002323
286 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 1004 0.0001439 0.002341
287 CELLULAR RESPONSE TO INTERLEUKIN 4 3 26 0.0001444 0.002342
288 REGULATION OF ALPHA BETA T CELL ACTIVATION 4 68 0.0001516 0.00244
289 ORGAN GROWTH 4 68 0.0001516 0.00244
290 NUCLEAR IMPORT 5 129 0.0001589 0.002549
291 LIPID METABOLIC PROCESS 14 1158 0.0001595 0.00255
292 REGULATION OF ASTROCYTE DIFFERENTIATION 3 27 0.000162 0.002573
293 POSITIVE REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 3 27 0.000162 0.002573
294 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1784 0.0001638 0.002593
295 POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION 4 70 0.0001696 0.002666
296 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 4 70 0.0001696 0.002666
297 BODY FLUID SECRETION 4 71 0.0001792 0.002808
298 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 28 0.000181 0.002826
299 ENERGY RESERVE METABOLIC PROCESS 4 72 0.0001892 0.002943
300 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 18 1805 0.0001897 0.002943
301 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 135 0.0001965 0.003037
302 POSITIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 4 73 0.0001995 0.003075
303 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 0.0002103 0.00322
304 CELLULAR RESPONSE TO RADIATION 5 137 0.0002104 0.00322
305 NEGATIVE REGULATION OF CELL PROLIFERATION 10 643 0.000215 0.003279
306 NEGATIVE REGULATION OF CELL CELL ADHESION 5 138 0.0002176 0.003309
307 CELLULAR GLUCOSE HOMEOSTASIS 4 75 0.0002215 0.003357
308 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 218 0.0002243 0.003389
309 HEMOSTASIS 7 311 0.0002286 0.003443
310 RESPONSE TO BACTERIUM 9 528 0.0002321 0.003477
311 CELLULAR LIPID METABOLIC PROCESS 12 913 0.0002324 0.003477
312 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 220 0.0002357 0.003514
313 NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 31 0.0002462 0.00366
314 FC EPSILON RECEPTOR SIGNALING PATHWAY 5 142 0.0002485 0.003673
315 TISSUE DEVELOPMENT 16 1518 0.0002487 0.003673
316 POSITIVE REGULATION OF GLIAL CELL DIFFERENTIATION 3 32 0.0002709 0.003951
317 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 0.0002709 0.003951
318 LIPID BIOSYNTHETIC PROCESS 9 539 0.0002702 0.003951
319 NEGATIVE REGULATION OF T CELL DIFFERENTIATION 3 32 0.0002709 0.003951
320 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 7 321 0.0002771 0.004029
321 T CELL RECEPTOR SIGNALING PATHWAY 5 146 0.0002826 0.004096
322 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 11 801 0.0002988 0.004318
323 REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 552 0.0003219 0.004636
324 T CELL HOMEOSTASIS 3 34 0.000325 0.004652
325 PROTEIN KINASE B SIGNALING 3 34 0.000325 0.004652
326 ORGAN REGENERATION 4 83 0.000327 0.004667
327 POSITIVE REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 4 85 0.0003582 0.005096
328 PROTEIN IMPORT 5 155 0.0003723 0.005281
329 PROTEIN LOCALIZATION TO NUCLEUS 5 156 0.0003834 0.005423
330 T CELL SELECTION 3 36 0.0003855 0.005436
331 REGULATION OF DNA METABOLIC PROCESS 7 340 0.0003919 0.005509
332 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 0.0003983 0.005583
333 NEGATIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 3 37 0.0004184 0.005811
334 TRICARBOXYLIC ACID METABOLIC PROCESS 3 37 0.0004184 0.005811
335 POSITIVE REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 3 37 0.0004184 0.005811
336 B CELL DIFFERENTIATION 4 89 0.0004268 0.005892
337 EPITHELIAL CELL PROLIFERATION 4 89 0.0004268 0.005892
338 REGENERATION 5 161 0.000443 0.006098
339 ORGAN MORPHOGENESIS 11 841 0.0004514 0.006196
340 REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 3 38 0.0004529 0.006199
341 CELLULAR RESPONSE TO LIGHT STIMULUS 4 91 0.0004644 0.006336
342 ERBB2 SIGNALING PATHWAY 3 39 0.0004893 0.006599
343 ASTROCYTE DIFFERENTIATION 3 39 0.0004893 0.006599
344 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 3 39 0.0004893 0.006599
345 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 3 39 0.0004893 0.006599
346 REPRODUCTION 14 1297 0.0005075 0.006825
347 MORPHOGENESIS OF A BRANCHING STRUCTURE 5 167 0.0005234 0.007019
348 NEGATIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 3 40 0.0005275 0.007053
349 CELL DEATH 12 1001 0.0005339 0.007119
350 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 0.0005466 0.007266
351 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 258 0.0005502 0.007283
352 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 0.0005509 0.007283
353 RESPONSE TO GROWTH FACTOR 8 475 0.0005691 0.007502
354 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 97 0.0005913 0.007773
355 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 0.0005985 0.007844
356 CELLULAR RESPONSE TO ABIOTIC STIMULUS 6 263 0.0006085 0.007953
357 RESPONSE TO VITAMIN 4 98 0.0006147 0.008011
358 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 99 0.0006386 0.0083
359 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 7 370 0.0006478 0.008305
360 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 43 0.0006533 0.008305
361 DEFENSE RESPONSE TO GRAM NEGATIVE BACTERIUM 3 43 0.0006533 0.008305
362 RESPONSE TO ABIOTIC STIMULUS 12 1024 0.0006529 0.008305
363 MYELOID LEUKOCYTE MEDIATED IMMUNITY 3 43 0.0006533 0.008305
364 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 0.0006533 0.008305
365 POSITIVE REGULATION OF SECRETION 7 370 0.0006478 0.008305
366 REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY 3 43 0.0006533 0.008305
367 MYELOID CELL DEVELOPMENT 3 44 0.0006991 0.008863
368 NEGATIVE REGULATION OF HOMOTYPIC CELL CELL ADHESION 4 102 0.0007145 0.009035
369 INNATE IMMUNE RESPONSE 9 619 0.000735 0.009268
370 LUNG MORPHOGENESIS 3 45 0.0007469 0.009393
371 REGULATION OF INTRACELLULAR TRANSPORT 9 621 0.000752 0.009432
372 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 381 0.0007695 0.0096
373 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 4 104 0.0007685 0.0096
374 REGULATION OF PROTEIN IMPORT 5 183 0.0007917 0.00985
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE RECEPTOR ACTIVITY 24 89 1.156e-38 1.074e-35
2 CYTOKINE RECEPTOR BINDING 18 271 1.768e-17 8.214e-15
3 SIGNAL TRANSDUCER ACTIVITY 34 1731 2.873e-16 8.896e-14
4 KINASE REGULATOR ACTIVITY 14 186 1.622e-14 3.767e-12
5 CYTOKINE BINDING 11 92 7.37e-14 1.369e-11
6 RECEPTOR BINDING 29 1476 1.021e-13 1.581e-11
7 KINASE BINDING 19 606 1.725e-12 2.289e-10
8 MOLECULAR FUNCTION REGULATOR 25 1353 3.292e-11 3.822e-09
9 KINASE ACTIVITY 20 842 6.193e-11 6.392e-09
10 ENZYME BINDING 27 1737 2.15e-10 1.997e-08
11 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 3.286e-10 2.544e-08
12 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 3.193e-10 2.544e-08
13 SIGNALING RECEPTOR ACTIVITY 24 1393 3.826e-10 2.545e-08
14 INSULIN RECEPTOR SUBSTRATE BINDING 5 11 3.835e-10 2.545e-08
15 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 1.151e-09 6.685e-08
16 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 20 992 1.098e-09 6.685e-08
17 RECEPTOR ACTIVITY 24 1649 1.097e-08 5.996e-07
18 KINASE INHIBITOR ACTIVITY 7 89 6.078e-08 3.137e-06
19 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 9 228 2.86e-07 1.398e-05
20 HORMONE RECEPTOR BINDING 8 168 3.296e-07 1.531e-05
21 PROTEIN PHOSPHATASE BINDING 7 120 4.759e-07 2.105e-05
22 GROWTH FACTOR BINDING 7 123 5.628e-07 2.377e-05
23 ENZYME REGULATOR ACTIVITY 16 959 8.642e-07 3.491e-05
24 PROTEIN KINASE ACTIVITY 13 640 1.238e-06 4.794e-05
25 CYTOKINE ACTIVITY 8 219 2.434e-06 9.046e-05
26 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 9 303 3.035e-06 0.0001084
27 PHOSPHATASE BINDING 7 162 3.57e-06 0.0001228
28 PROTEIN TYROSINE KINASE ACTIVITY 7 176 6.167e-06 0.0002046
29 GROWTH FACTOR RECEPTOR BINDING 6 129 1.211e-05 0.000388
30 GLUCOCORTICOID RECEPTOR BINDING 3 14 2.092e-05 0.000648
31 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 3.201e-05 0.0009592
32 PROTEIN DIMERIZATION ACTIVITY 15 1149 3.751e-05 0.001089
33 RNA POLYMERASE II CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 4 53 5.699e-05 0.001604
34 PROTEIN TYROSINE KINASE BINDING 4 54 6.137e-05 0.001677
35 STEROID HORMONE RECEPTOR BINDING 4 81 0.0002978 0.007905
36 PEPTIDE HORMONE BINDING 3 36 0.0003855 0.009949
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 8.501e-13 4.965e-10
2 EXTRINSIC COMPONENT OF MEMBRANE 11 252 4.339e-09 1.267e-06
3 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 10 237 3.182e-08 6.194e-06
4 RECEPTOR COMPLEX 11 327 6.337e-08 9.252e-06
5 INTRINSIC COMPONENT OF PLASMA MEMBRANE 21 1649 1.073e-06 0.0001254
6 PLASMA MEMBRANE RECEPTOR COMPLEX 7 175 5.941e-06 0.0005782
7 CELL SURFACE 13 757 7.761e-06 0.0006475
8 MEMBRANE PROTEIN COMPLEX 15 1020 9.285e-06 0.0006778
9 TRANSFERASE COMPLEX 12 703 1.917e-05 0.001235
10 EXTRACELLULAR SPACE 17 1376 2.114e-05 0.001235
11 SIDE OF MEMBRANE 9 428 4.738e-05 0.002515

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04630_Jak.STAT_signaling_pathway 79 155 4.903e-178 8.825e-176
2 hsa04151_PI3K_AKT_signaling_pathway 33 351 2.286e-37 2.057e-35
3 hsa04012_ErbB_signaling_pathway 16 87 6.642e-23 3.985e-21
4 hsa04380_Osteoclast_differentiation 16 128 4.632e-20 2.084e-18
5 hsa04910_Insulin_signaling_pathway 16 138 1.613e-19 5.806e-18
6 hsa04062_Chemokine_signaling_pathway 17 189 8.831e-19 2.649e-17
7 hsa04620_Toll.like_receptor_signaling_pathway 13 102 1.433e-16 3.684e-15
8 hsa04660_T_cell_receptor_signaling_pathway 13 108 3.097e-16 6.968e-15
9 hsa04650_Natural_killer_cell_mediated_cytotoxicity 13 136 6.674e-15 1.275e-13
10 hsa04662_B_cell_receptor_signaling_pathway 11 75 7.083e-15 1.275e-13
11 hsa04664_Fc_epsilon_RI_signaling_pathway 11 79 1.291e-14 2.112e-13
12 hsa04640_Hematopoietic_cell_lineage 11 88 4.444e-14 6.161e-13
13 hsa04510_Focal_adhesion 14 200 4.45e-14 6.161e-13
14 hsa04210_Apoptosis 11 89 5.054e-14 6.499e-13
15 hsa04722_Neurotrophin_signaling_pathway 12 127 9.041e-14 1.044e-12
16 hsa04973_Carbohydrate_digestion_and_absorption 9 44 9.276e-14 1.044e-12
17 hsa04150_mTOR_signaling_pathway 9 52 4.694e-13 4.97e-12
18 hsa04370_VEGF_signaling_pathway 9 76 1.685e-11 1.685e-10
19 hsa04914_Progesterone.mediated_oocyte_maturation 9 87 5.859e-11 5.551e-10
20 hsa04666_Fc_gamma_R.mediated_phagocytosis 9 95 1.309e-10 1.178e-09
21 hsa04014_Ras_signaling_pathway 12 236 1.404e-10 1.204e-09
22 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 2.76e-10 2.258e-09
23 hsa04920_Adipocytokine_signaling_pathway 7 68 9.137e-09 7.151e-08
24 hsa04670_Leukocyte_transendothelial_migration 8 117 1.988e-08 1.491e-07
25 hsa04070_Phosphatidylinositol_signaling_system 7 78 2.413e-08 1.737e-07
26 hsa04810_Regulation_of_actin_cytoskeleton 9 214 1.672e-07 1.158e-06
27 hsa04110_Cell_cycle 6 128 1.159e-05 7.724e-05
28 hsa04310_Wnt_signaling_pathway 6 151 2.96e-05 0.0001903
29 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.0002251 0.001397
30 hsa04672_Intestinal_immune_network_for_IgA_production 3 49 0.0009588 0.005753
31 hsa04144_Endocytosis 5 203 0.001258 0.007303
32 hsa00562_Inositol_phosphate_metabolism 3 57 0.001489 0.008374
33 hsa04115_p53_signaling_pathway 3 69 0.002577 0.01405
34 hsa04390_Hippo_signaling_pathway 4 154 0.003246 0.01719
35 hsa04010_MAPK_signaling_pathway 5 268 0.004187 0.02154
36 hsa04320_Dorso.ventral_axis_formation 2 25 0.004357 0.02179
37 hsa04350_TGF.beta_signaling_pathway 3 85 0.004643 0.02259
38 hsa04330_Notch_signaling_pathway 2 47 0.01485 0.07032
39 hsa04720_Long.term_potentiation 2 70 0.03129 0.1444
40 hsa04520_Adherens_junction 2 73 0.0338 0.1521
41 hsa04540_Gap_junction 2 90 0.04935 0.2167
42 hsa04912_GnRH_signaling_pathway 2 101 0.06054 0.2534
43 hsa04916_Melanogenesis 2 101 0.06054 0.2534
44 hsa04530_Tight_junction 2 133 0.0972 0.3976

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

RFPL1S

hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-505-3p 11 AKT3 Sponge network -0.223 0.70704 -0.749 0.06936 0.466
2

AGAP11

hsa-let-7f-1-3p;hsa-miR-107;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-3662;hsa-miR-3682-3p;hsa-miR-421;hsa-miR-590-5p 11 LEPR Sponge network -1.728 0.00016 -2.834 0 0.392
3

PCA3

hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-25-3p;hsa-miR-320b;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-940 10 SOCS2 Sponge network -2.778 8.0E-5 -1.686 0 0.385
4

PCA3

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-130b-3p;hsa-miR-135b-5p;hsa-miR-148b-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-182-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-330-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-3682-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-3p 36 IL6ST Sponge network -2.778 8.0E-5 -1.425 0 0.371
5

EMX2OS

hsa-miR-107;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-362-3p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-505-3p;hsa-miR-577 12 AKT3 Sponge network -1.088 0.10042 -0.749 0.06936 0.354
6

PCA3

hsa-let-7a-3p;hsa-let-7b-3p;hsa-miR-1271-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-296-5p;hsa-miR-320b;hsa-miR-382-5p;hsa-miR-590-3p;hsa-miR-629-5p;hsa-miR-708-5p;hsa-miR-96-5p 14 SPRY3 Sponge network -2.778 8.0E-5 -0.343 0.26214 0.353
7

PCA3

hsa-let-7a-3p;hsa-let-7b-3p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-181a-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-19b-3p;hsa-miR-224-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 20 CCND2 Sponge network -2.778 8.0E-5 -0.496 0.3 0.318
8

MEG3

hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-577;hsa-miR-616-5p 11 AKT3 Sponge network -1.645 0.00049 -0.749 0.06936 0.312
9

PCA3

hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-144-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p 28 PIK3R1 Sponge network -2.778 8.0E-5 -1.094 2.0E-5 0.309
10

MEG3

hsa-miR-103a-3p;hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-219a-1-3p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-629-3p;hsa-miR-93-3p 21 IL6ST Sponge network -1.645 0.00049 -1.425 0 0.295
11

MEG3

hsa-miR-107;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-3662;hsa-miR-429;hsa-miR-7-1-3p 11 LEPR Sponge network -1.645 0.00049 -2.834 0 0.289
12

PCA3

hsa-let-7f-1-3p;hsa-miR-107;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-23a-3p;hsa-miR-320b;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-3662;hsa-miR-3682-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p 14 LEPR Sponge network -2.778 8.0E-5 -2.834 0 0.281
13

PCA3

hsa-let-7f-1-3p;hsa-miR-128-3p;hsa-miR-1296-5p;hsa-miR-182-5p;hsa-miR-19a-3p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-23a-3p;hsa-miR-27a-3p;hsa-miR-320b;hsa-miR-3682-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-940;hsa-miR-96-5p 17 LIFR Sponge network -2.778 8.0E-5 -3.62 0 0.264
14

PCA3

hsa-miR-130b-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-320b;hsa-miR-330-3p;hsa-miR-335-5p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p 10 SOS2 Sponge network -2.778 8.0E-5 -0.553 0.00084 0.258

Quest ID: cb34bb32f060ef3856b7f06566c509da