This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-21-5p | AKT2 | 1.51 | 0 | -0.34 | 1.0E-5 | miRNAWalker2 validate | -0.25 | 0 | NA | |
2 | hsa-miR-330-5p | AKT2 | 0.44 | 0.00533 | -0.34 | 1.0E-5 | miRanda | -0.1 | 1.0E-5 | NA | |
3 | hsa-miR-342-3p | AKT2 | -0.32 | 0.04498 | -0.34 | 1.0E-5 | mirMAP | -0.12 | 0 | NA | |
4 | hsa-miR-106b-5p | AKT3 | 0.65 | 0 | -0.66 | 0.00047 | miRNATAP | -0.26 | 0.00148 | NA | |
5 | hsa-miR-107 | AKT3 | 0.24 | 0.01708 | -0.66 | 0.00047 | PITA; miRanda | -0.6 | 0 | NA | |
6 | hsa-miR-122-5p | AKT3 | -1.24 | 0 | -0.66 | 0.00047 | miRNAWalker2 validate; miRTarBase | -0.28 | 0 | 24244539 | miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer |
7 | hsa-miR-146b-5p | AKT3 | 0.42 | 0.04574 | -0.66 | 0.00047 | miRNAWalker2 validate | -0.16 | 0.00026 | NA | |
8 | hsa-miR-15a-5p | AKT3 | 0.35 | 0.00077 | -0.66 | 0.00047 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.27 | 0.00291 | NA | |
9 | hsa-miR-17-3p | AKT3 | 0.41 | 0.00422 | -0.66 | 0.00047 | miRNATAP | -0.35 | 0 | NA | |
10 | hsa-miR-17-5p | AKT3 | 0.7 | 2.0E-5 | -0.66 | 0.00047 | TargetScan; miRNATAP | -0.29 | 0 | NA | |
11 | hsa-miR-20a-5p | AKT3 | 0.85 | 0 | -0.66 | 0.00047 | miRNATAP | -0.29 | 0 | NA | |
12 | hsa-miR-32-3p | AKT3 | 0.22 | 0.20722 | -0.66 | 0.00047 | mirMAP | -0.23 | 4.0E-5 | NA | |
13 | hsa-miR-33a-3p | AKT3 | -0.68 | 1.0E-5 | -0.66 | 0.00047 | mirMAP | -0.23 | 0.0001 | NA | |
14 | hsa-miR-362-3p | AKT3 | 0.81 | 0 | -0.66 | 0.00047 | miRanda | -0.22 | 0.00083 | NA | |
15 | hsa-miR-362-5p | AKT3 | 0.72 | 2.0E-5 | -0.66 | 0.00047 | PITA; TargetScan; miRNATAP | -0.15 | 0.00734 | NA | |
16 | hsa-miR-374a-5p | AKT3 | 0.02 | 0.86978 | -0.66 | 0.00047 | mirMAP | -0.28 | 0.00294 | NA | |
17 | hsa-miR-502-3p | AKT3 | 0.66 | 0 | -0.66 | 0.00047 | miRNATAP | -0.26 | 0.0008 | NA | |
18 | hsa-miR-616-5p | AKT3 | 0.15 | 0.40284 | -0.66 | 0.00047 | mirMAP | -0.2 | 0.0001 | NA | |
19 | hsa-miR-93-5p | AKT3 | 1.4 | 0 | -0.66 | 0.00047 | miRNATAP | -0.28 | 1.0E-5 | NA | |
20 | hsa-miR-330-5p | BCL2L1 | 0.44 | 0.00533 | 0.02 | 0.82745 | PITA; miRanda; miRNATAP | -0.15 | 0 | NA | |
21 | hsa-miR-342-3p | BCL2L1 | -0.32 | 0.04498 | 0.02 | 0.82745 | PITA; miRanda; miRNATAP | -0.12 | 8.0E-5 | NA | |
22 | hsa-miR-342-5p | BCL2L1 | -0.78 | 0 | 0.02 | 0.82745 | miRNATAP | -0.11 | 0.00084 | NA | |
23 | hsa-miR-484 | BCL2L1 | 0.09 | 0.45398 | 0.02 | 0.82745 | miRNAWalker2 validate | -0.21 | 0 | NA | |
24 | hsa-miR-192-5p | CBL | -0.5 | 0.00345 | 0.05 | 0.65471 | mirMAP | -0.24 | 0 | NA | |
25 | hsa-miR-22-3p | CBL | -0.63 | 0 | 0.05 | 0.65471 | MirTarget | -0.29 | 0 | NA | |
26 | hsa-miR-29c-3p | CBL | -1.44 | 0 | 0.05 | 0.65471 | mirMAP | -0.11 | 0.00382 | NA | |
27 | hsa-miR-618 | CBL | 0.14 | 0.51715 | 0.05 | 0.65471 | mirMAP | -0.12 | 4.0E-5 | NA | |
28 | hsa-miR-106a-5p | CCND1 | -0.46 | 0.00972 | -0.9 | 1.0E-5 | MirTarget; miRNATAP | -0.26 | 0 | NA | |
29 | hsa-miR-106b-5p | CCND1 | 0.65 | 0 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.43 | 0 | NA | |
30 | hsa-miR-1266-5p | CCND1 | 1.63 | 0 | -0.9 | 1.0E-5 | MirTarget | -0.23 | 0 | NA | |
31 | hsa-miR-15b-5p | CCND1 | 0.23 | 0.08248 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.54 | 0 | NA | |
32 | hsa-miR-16-5p | CCND1 | -0.4 | 0.0001 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.31 | 0.00178 | 23991964; 22922827; 18483394 | At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL |
33 | hsa-miR-17-5p | CCND1 | 0.7 | 2.0E-5 | -0.9 | 1.0E-5 | miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP | -0.34 | 0 | 26431674 | Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene |
34 | hsa-miR-186-5p | CCND1 | -0.06 | 0.53529 | -0.9 | 1.0E-5 | mirMAP | -0.32 | 0.00286 | NA | |
35 | hsa-miR-19a-3p | CCND1 | 1.02 | 0 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.28 | 0 | 25985117 | Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression |
36 | hsa-miR-19b-1-5p | CCND1 | -0.28 | 0.07831 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.31 | 0 | NA | |
37 | hsa-miR-19b-3p | CCND1 | 0.6 | 0.00017 | -0.9 | 1.0E-5 | miRNATAP | -0.34 | 0 | NA | |
38 | hsa-miR-20a-5p | CCND1 | 0.85 | 0 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.33 | 0 | NA | |
39 | hsa-miR-20b-5p | CCND1 | 0.46 | 0.02859 | -0.9 | 1.0E-5 | MirTarget; miRNATAP | -0.23 | 0 | NA | |
40 | hsa-miR-340-5p | CCND1 | -0 | 0.9685 | -0.9 | 1.0E-5 | mirMAP | -0.32 | 0.00013 | NA | |
41 | hsa-miR-425-5p | CCND1 | 0.59 | 2.0E-5 | -0.9 | 1.0E-5 | miRNAWalker2 validate | -0.39 | 0 | NA | |
42 | hsa-miR-503-5p | CCND1 | 0.19 | 0.26842 | -0.9 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; MirTarget | -0.16 | 0.00815 | 26047605; 23731275 | MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC |
43 | hsa-miR-589-3p | CCND1 | 1.17 | 0 | -0.9 | 1.0E-5 | MirTarget | -0.18 | 0.00124 | NA | |
44 | hsa-miR-616-5p | CCND1 | 0.15 | 0.40284 | -0.9 | 1.0E-5 | mirMAP | -0.26 | 1.0E-5 | NA | |
45 | hsa-miR-7-1-3p | CCND1 | -0.57 | 2.0E-5 | -0.9 | 1.0E-5 | mirMAP | -0.26 | 0.00057 | NA | |
46 | hsa-miR-9-5p | CCND1 | 1.26 | 9.0E-5 | -0.9 | 1.0E-5 | miRNAWalker2 validate | -0.14 | 1.0E-5 | NA | |
47 | hsa-miR-92a-3p | CCND1 | 0.21 | 0.13429 | -0.9 | 1.0E-5 | miRNAWalker2 validate | -0.41 | 0 | NA | |
48 | hsa-miR-93-5p | CCND1 | 1.4 | 0 | -0.9 | 1.0E-5 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.34 | 0 | NA | |
49 | hsa-miR-942-5p | CCND1 | 0.35 | 0.02833 | -0.9 | 1.0E-5 | MirTarget | -0.25 | 0.00012 | NA | |
50 | hsa-miR-130b-5p | CCND2 | 0.17 | 0.33761 | 0.36 | 0.03656 | mirMAP | -0.17 | 0.00018 | NA | |
51 | hsa-miR-20a-5p | CCND2 | 0.85 | 0 | 0.36 | 0.03656 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.16 | 0.00121 | NA | |
52 | hsa-miR-28-5p | CCND2 | -0.43 | 0 | 0.36 | 0.03656 | miRanda | -0.48 | 0 | NA | |
53 | hsa-miR-33a-3p | CCND2 | -0.68 | 1.0E-5 | 0.36 | 0.03656 | MirTarget | -0.26 | 0 | NA | |
54 | hsa-miR-3607-3p | CCND2 | -2.16 | 0 | 0.36 | 0.03656 | mirMAP | -0.12 | 0.0007 | NA | |
55 | hsa-miR-378a-3p | CCND2 | -1.19 | 0 | 0.36 | 0.03656 | miRNAWalker2 validate | -0.18 | 2.0E-5 | NA | |
56 | hsa-miR-548v | CCND2 | -0.27 | 0.17626 | 0.36 | 0.03656 | MirTarget | -0.15 | 0.00034 | NA | |
57 | hsa-miR-616-5p | CCND2 | 0.15 | 0.40284 | 0.36 | 0.03656 | mirMAP | -0.32 | 0 | NA | |
58 | hsa-miR-618 | CCND2 | 0.14 | 0.51715 | 0.36 | 0.03656 | mirMAP | -0.23 | 0 | NA | |
59 | hsa-miR-27b-3p | CCND3 | -0.82 | 0 | 0.08 | 0.47843 | miRNAWalker2 validate | -0.24 | 0 | NA | |
60 | hsa-miR-320a | CCND3 | 0.33 | 0.02214 | 0.08 | 0.47843 | miRanda | -0.12 | 0.00135 | NA | |
61 | hsa-miR-324-5p | CISH | 0.37 | 0.00592 | -1.22 | 0 | miRanda | -0.22 | 0.00106 | NA | |
62 | hsa-miR-21-5p | CNTFR | 1.51 | 0 | -3.51 | 0 | miRNATAP | -1.1 | 0 | NA | |
63 | hsa-miR-589-5p | CNTFR | 1.19 | 0 | -3.51 | 0 | miRNATAP | -0.73 | 0.00049 | NA | |
64 | hsa-miR-324-3p | CREBBP | 0.26 | 0.05061 | -0.2 | 0.01387 | miRNAWalker2 validate | -0.12 | 3.0E-5 | NA | |
65 | hsa-miR-330-5p | CREBBP | 0.44 | 0.00533 | -0.2 | 0.01387 | miRanda | -0.11 | 1.0E-5 | NA | |
66 | hsa-miR-769-5p | CREBBP | 0.22 | 0.03334 | -0.2 | 0.01387 | miRNAWalker2 validate | -0.13 | 0.00077 | NA | |
67 | hsa-miR-19a-3p | CSF2RB | 1.02 | 0 | -0.51 | 0.00683 | MirTarget | -0.12 | 0.00885 | NA | |
68 | hsa-miR-19b-3p | CSF2RB | 0.6 | 0.00017 | -0.51 | 0.00683 | MirTarget | -0.15 | 0.00713 | NA | |
69 | hsa-miR-204-5p | CSF2RB | -0.54 | 0.03309 | -0.51 | 0.00683 | MirTarget | -0.11 | 0.00224 | NA | |
70 | hsa-miR-30b-3p | CSF2RB | -0.44 | 0.00095 | -0.51 | 0.00683 | MirTarget | -0.2 | 0.00366 | NA | |
71 | hsa-miR-455-5p | CSF2RB | -0.27 | 0.05813 | -0.51 | 0.00683 | miRanda | -0.37 | 0 | NA | |
72 | hsa-miR-532-5p | CSF2RB | 1.03 | 0 | -0.51 | 0.00683 | MirTarget | -0.33 | 0 | NA | |
73 | hsa-miR-339-5p | EP300 | 0.28 | 0.03557 | -0.2 | 0.07049 | miRanda | -0.16 | 0.0001 | NA | |
74 | hsa-miR-342-3p | EP300 | -0.32 | 0.04498 | -0.2 | 0.07049 | MirTarget; PITA; miRanda; miRNATAP | -0.11 | 0.00085 | NA | |
75 | hsa-let-7e-5p | GHR | 0.04 | 0.81107 | -3.07 | 0 | miRNATAP | -0.38 | 0.00015 | NA | |
76 | hsa-miR-15a-5p | GHR | 0.35 | 0.00077 | -3.07 | 0 | MirTarget; miRNATAP | -0.55 | 8.0E-5 | NA | |
77 | hsa-miR-29a-5p | GHR | -0.11 | 0.34962 | -3.07 | 0 | mirMAP; miRNATAP | -0.36 | 0.00254 | NA | |
78 | hsa-miR-361-5p | GHR | 0.23 | 0.00962 | -3.07 | 0 | miRanda | -0.69 | 2.0E-5 | NA | |
79 | hsa-miR-421 | GHR | 0.94 | 0 | -3.07 | 0 | miRanda | -0.76 | 0 | NA | |
80 | hsa-miR-361-5p | IFNAR1 | 0.23 | 0.00962 | -0.79 | 0 | miRanda | -0.16 | 0.00059 | NA | |
81 | hsa-miR-3913-5p | IFNAR1 | 0.25 | 0.0628 | -0.79 | 0 | mirMAP | -0.13 | 4.0E-5 | NA | |
82 | hsa-miR-181b-5p | IFNGR1 | 0.49 | 0.00105 | -0.36 | 0.01168 | miRNAWalker2 validate | -0.27 | 0 | NA | |
83 | hsa-miR-362-3p | IFNGR1 | 0.81 | 0 | -0.36 | 0.01168 | miRanda | -0.13 | 0.00937 | NA | |
84 | hsa-miR-26b-5p | IFNGR2 | -1.11 | 0 | 0.13 | 0.22292 | miRNAWalker2 validate | -0.13 | 0.00238 | NA | |
85 | hsa-miR-455-5p | IL10RA | -0.27 | 0.05813 | -0.99 | 0 | miRanda | -0.3 | 0 | NA | |
86 | hsa-miR-326 | IL11RA | -1.88 | 0 | 0.13 | 0.31327 | miRanda | -0.11 | 0.00029 | NA | |
87 | hsa-miR-330-5p | IL11RA | 0.44 | 0.00533 | 0.13 | 0.31327 | miRanda | -0.19 | 0 | NA | |
88 | hsa-miR-455-5p | IL12RB1 | -0.27 | 0.05813 | -0.72 | 0.00084 | miRanda | -0.34 | 1.0E-5 | NA | |
89 | hsa-miR-338-3p | IL12RB2 | 0.54 | 0.00461 | -0.41 | 0.10321 | miRanda | -0.2 | 0.0024 | NA | |
90 | hsa-miR-128-3p | IL13RA1 | 0.29 | 0.01144 | -0.7 | 0 | MirTarget | -0.13 | 0.00645 | NA | |
91 | hsa-miR-16-2-3p | IL13RA1 | -0.03 | 0.80516 | -0.7 | 0 | MirTarget | -0.19 | 0 | NA | |
92 | hsa-miR-181a-2-3p | IL13RA1 | -0.23 | 0.2364 | -0.7 | 0 | MirTarget | -0.15 | 0 | NA | |
93 | hsa-miR-185-5p | IL13RA1 | 0.48 | 0 | -0.7 | 0 | MirTarget | -0.15 | 0.00899 | NA | |
94 | hsa-miR-188-5p | IL13RA1 | 1.12 | 0 | -0.7 | 0 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
95 | hsa-miR-324-5p | IL13RA1 | 0.37 | 0.00592 | -0.7 | 0 | miRanda | -0.21 | 0 | NA | |
96 | hsa-miR-330-3p | IL13RA1 | -0.33 | 0.03161 | -0.7 | 0 | MirTarget; PITA; miRNATAP | -0.13 | 0.0003 | NA | |
97 | hsa-miR-331-3p | IL13RA1 | -0.28 | 0.03738 | -0.7 | 0 | MirTarget | -0.13 | 0.0009 | NA | |
98 | hsa-miR-331-5p | IL13RA1 | 0.21 | 0.12077 | -0.7 | 0 | miRNATAP | -0.24 | 0 | NA | |
99 | hsa-miR-338-5p | IL13RA1 | -0.22 | 0.25239 | -0.7 | 0 | MirTarget; PITA | -0.13 | 1.0E-5 | NA | |
100 | hsa-miR-421 | IL13RA1 | 0.94 | 0 | -0.7 | 0 | miRanda | -0.12 | 0.00012 | NA | |
101 | hsa-miR-148b-3p | IL13RA2 | 0.27 | 0.00185 | -4.49 | 0 | miRNAWalker2 validate | -0.8 | 0.00077 | NA | |
102 | hsa-miR-107 | IL15 | 0.24 | 0.01708 | -0.3 | 0.13357 | miRanda; miRNATAP | -0.56 | 0 | NA | |
103 | hsa-miR-148a-3p | IL15 | -0.75 | 0 | -0.3 | 0.13357 | MirTarget | -0.36 | 0 | NA | |
104 | hsa-miR-192-5p | IL15 | -0.5 | 0.00345 | -0.3 | 0.13357 | miRNAWalker2 validate | -0.31 | 0 | NA | |
105 | hsa-miR-19a-3p | IL15 | 1.02 | 0 | -0.3 | 0.13357 | MirTarget | -0.17 | 0.00047 | NA | |
106 | hsa-miR-19b-3p | IL15 | 0.6 | 0.00017 | -0.3 | 0.13357 | MirTarget | -0.25 | 4.0E-5 | NA | |
107 | hsa-miR-374a-5p | IL20RA | 0.02 | 0.86978 | -3.19 | 0 | mirMAP | -0.85 | 0.00024 | NA | |
108 | hsa-miR-374b-5p | IL20RA | -0.31 | 0.00301 | -3.19 | 0 | mirMAP | -0.64 | 0.00422 | NA | |
109 | hsa-miR-664a-3p | IL20RA | 0.49 | 0.00073 | -3.19 | 0 | MirTarget; mirMAP | -0.53 | 0.00091 | NA | |
110 | hsa-miR-107 | IL6 | 0.24 | 0.01708 | -2.01 | 0 | miRanda | -0.96 | 0 | NA | |
111 | hsa-miR-361-5p | IL6 | 0.23 | 0.00962 | -2.01 | 0 | miRanda | -0.75 | 6.0E-5 | NA | |
112 | hsa-miR-365a-3p | IL6 | 0.16 | 0.15325 | -2.01 | 0 | miRNAWalker2 validate | -0.51 | 0.00048 | NA | |
113 | hsa-let-7e-5p | IL6R | 0.04 | 0.81107 | -0.2 | 0.38255 | miRNATAP | -0.31 | 3.0E-5 | NA | |
114 | hsa-let-7i-5p | IL6R | -0.14 | 0.15414 | -0.2 | 0.38255 | miRNATAP | -0.44 | 6.0E-5 | NA | |
115 | hsa-miR-103a-2-5p | IL6R | 1.17 | 0 | -0.2 | 0.38255 | mirMAP | -0.15 | 0.00673 | NA | |
116 | hsa-miR-125a-5p | IL6R | -0.91 | 0 | -0.2 | 0.38255 | MirTarget; miRanda | -0.24 | 0.00014 | NA | |
117 | hsa-miR-130a-3p | IL6R | -1.53 | 0 | -0.2 | 0.38255 | mirMAP | -0.2 | 0.00111 | NA | |
118 | hsa-miR-141-3p | IL6R | -0.35 | 0.257 | -0.2 | 0.38255 | MirTarget | -0.14 | 5.0E-5 | NA | |
119 | hsa-miR-141-5p | IL6R | -0.5 | 0.10265 | -0.2 | 0.38255 | MirTarget | -0.12 | 0.0014 | NA | |
120 | hsa-miR-155-5p | IL6R | 0.01 | 0.95651 | -0.2 | 0.38255 | MirTarget | -0.28 | 0 | NA | |
121 | hsa-miR-182-5p | IL6R | 1.97 | 0 | -0.2 | 0.38255 | mirMAP | -0.14 | 1.0E-5 | NA | |
122 | hsa-miR-200a-3p | IL6R | -1.5 | 3.0E-5 | -0.2 | 0.38255 | MirTarget | -0.16 | 0 | NA | |
123 | hsa-miR-21-5p | IL6R | 1.51 | 0 | -0.2 | 0.38255 | MirTarget; miRNATAP | -0.54 | 0 | NA | |
124 | hsa-miR-23a-3p | IL6R | -0.18 | 0.13598 | -0.2 | 0.38255 | miRNAWalker2 validate; miRTarBase; MirTarget | -0.48 | 0 | NA | |
125 | hsa-miR-301a-3p | IL6R | 0.84 | 0 | -0.2 | 0.38255 | mirMAP | -0.27 | 1.0E-5 | NA | |
126 | hsa-miR-30b-5p | IL6R | -0.54 | 2.0E-5 | -0.2 | 0.38255 | mirMAP | -0.34 | 6.0E-5 | NA | |
127 | hsa-miR-330-3p | IL6R | -0.33 | 0.03161 | -0.2 | 0.38255 | miRNATAP | -0.4 | 0 | NA | |
128 | hsa-miR-331-3p | IL6R | -0.28 | 0.03738 | -0.2 | 0.38255 | MirTarget | -0.27 | 0.00073 | NA | |
129 | hsa-miR-421 | IL6R | 0.94 | 0 | -0.2 | 0.38255 | mirMAP | -0.18 | 0.0031 | NA | |
130 | hsa-miR-501-5p | IL6R | 1.15 | 0 | -0.2 | 0.38255 | miRNATAP | -0.18 | 0.00194 | NA | |
131 | hsa-miR-103a-3p | IL6ST | 0.77 | 0 | -1.92 | 0 | mirMAP | -0.67 | 1.0E-5 | NA | |
132 | hsa-miR-1301-3p | IL6ST | 1.12 | 0 | -1.92 | 0 | MirTarget | -0.34 | 0.00023 | NA | |
133 | hsa-miR-130b-3p | IL6ST | 0.69 | 0.00011 | -1.92 | 0 | miRNATAP | -0.29 | 0.00192 | NA | |
134 | hsa-miR-148b-5p | IL6ST | 0.3 | 0.02557 | -1.92 | 0 | mirMAP | -0.44 | 0.00054 | NA | |
135 | hsa-miR-16-1-3p | IL6ST | 0.39 | 0.00112 | -1.92 | 0 | mirMAP | -0.38 | 0.00651 | NA | |
136 | hsa-miR-17-5p | IL6ST | 0.7 | 2.0E-5 | -1.92 | 0 | TargetScan | -0.54 | 0 | NA | |
137 | hsa-miR-181b-5p | IL6ST | 0.49 | 0.00105 | -1.92 | 0 | mirMAP | -0.3 | 0.00837 | NA | |
138 | hsa-miR-19a-3p | IL6ST | 1.02 | 0 | -1.92 | 0 | mirMAP; miRNATAP | -0.33 | 8.0E-5 | NA | |
139 | hsa-miR-19b-3p | IL6ST | 0.6 | 0.00017 | -1.92 | 0 | mirMAP; miRNATAP | -0.38 | 0.00032 | NA | |
140 | hsa-miR-21-5p | IL6ST | 1.51 | 0 | -1.92 | 0 | mirMAP | -0.64 | 0 | NA | |
141 | hsa-miR-301a-3p | IL6ST | 0.84 | 0 | -1.92 | 0 | mirMAP; miRNATAP | -0.52 | 0 | NA | |
142 | hsa-miR-32-3p | IL6ST | 0.22 | 0.20722 | -1.92 | 0 | mirMAP | -0.27 | 0.00761 | NA | |
143 | hsa-miR-362-3p | IL6ST | 0.81 | 0 | -1.92 | 0 | PITA; miRanda; miRNATAP | -0.37 | 0.0023 | NA | |
144 | hsa-miR-362-5p | IL6ST | 0.72 | 2.0E-5 | -1.92 | 0 | mirMAP | -0.37 | 0.00018 | NA | |
145 | hsa-miR-421 | IL6ST | 0.94 | 0 | -1.92 | 0 | PITA; miRanda; mirMAP | -0.32 | 0.00069 | NA | |
146 | hsa-miR-452-5p | IL6ST | 1.92 | 0 | -1.92 | 0 | mirMAP | -0.22 | 0.00064 | NA | |
147 | hsa-miR-455-5p | IL6ST | -0.27 | 0.05813 | -1.92 | 0 | miRanda | -0.38 | 0.00126 | NA | |
148 | hsa-miR-501-5p | IL6ST | 1.15 | 0 | -1.92 | 0 | mirMAP | -0.39 | 1.0E-5 | NA | |
149 | hsa-miR-532-5p | IL6ST | 1.03 | 0 | -1.92 | 0 | PITA | -0.59 | 0 | NA | |
150 | hsa-miR-589-3p | IL6ST | 1.17 | 0 | -1.92 | 0 | mirMAP | -0.38 | 5.0E-5 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | CYTOKINE MEDIATED SIGNALING PATHWAY | 35 | 452 | 3.613e-39 | 8.675e-36 |
2 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 52 | 1848 | 3.729e-39 | 8.675e-36 |
3 | RESPONSE TO CYTOKINE | 38 | 714 | 1.134e-36 | 1.759e-33 |
4 | CELLULAR RESPONSE TO CYTOKINE STIMULUS | 35 | 606 | 1.121e-34 | 1.305e-31 |
5 | STAT CASCADE | 14 | 50 | 8.816e-24 | 6.837e-21 |
6 | JAK STAT CASCADE | 14 | 50 | 8.816e-24 | 6.837e-21 |
7 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 35 | 1656 | 6.129e-20 | 4.074e-17 |
8 | INTRACELLULAR SIGNAL TRANSDUCTION | 34 | 1572 | 1.326e-19 | 7.713e-17 |
9 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 34 | 1618 | 3.275e-19 | 1.693e-16 |
10 | REGULATION OF IMMUNE RESPONSE | 26 | 858 | 3.555e-18 | 1.654e-15 |
11 | REGULATION OF KINASE ACTIVITY | 25 | 776 | 4.448e-18 | 1.881e-15 |
12 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 35 | 1929 | 8.105e-18 | 3.143e-15 |
13 | REGULATION OF PROTEIN MODIFICATION PROCESS | 33 | 1710 | 1.849e-17 | 6.616e-15 |
14 | REGULATION OF JAK STAT CASCADE | 14 | 144 | 7.23e-17 | 2.103e-14 |
15 | REGULATION OF IMMUNE SYSTEM PROCESS | 30 | 1403 | 6.345e-17 | 2.103e-14 |
16 | REGULATION OF STAT CASCADE | 14 | 144 | 7.23e-17 | 2.103e-14 |
17 | REGULATION OF TRANSFERASE ACTIVITY | 25 | 946 | 4.606e-16 | 1.261e-13 |
18 | ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY | 22 | 689 | 8.579e-16 | 2.218e-13 |
19 | RESPONSE TO HORMONE | 24 | 893 | 1.444e-15 | 3.537e-13 |
20 | TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY | 19 | 498 | 4.711e-15 | 1.096e-12 |
21 | RESPONSE TO ENDOGENOUS STIMULUS | 28 | 1450 | 1.357e-14 | 3.006e-12 |
22 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 24 | 1008 | 2.102e-14 | 4.446e-12 |
23 | CELLULAR RESPONSE TO HORMONE STIMULUS | 19 | 552 | 3.015e-14 | 5.846e-12 |
24 | REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN | 9 | 44 | 2.973e-14 | 5.846e-12 |
25 | RESPONSE TO PEPTIDE | 17 | 404 | 3.291e-14 | 6.125e-12 |
26 | PHOSPHORYLATION | 25 | 1228 | 1.776e-13 | 3.178e-11 |
27 | RESPONSE TO OXYGEN CONTAINING COMPOUND | 26 | 1381 | 3.029e-13 | 5.22e-11 |
28 | CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS | 7 | 20 | 3.534e-13 | 5.872e-11 |
29 | REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS | 9 | 59 | 5.057e-13 | 8.113e-11 |
30 | POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN | 8 | 37 | 5.306e-13 | 8.23e-11 |
31 | REGULATION OF RESPONSE TO INTERFERON GAMMA | 7 | 22 | 7.732e-13 | 1.16e-10 |
32 | RESPONSE TO NITROGEN COMPOUND | 21 | 859 | 8.074e-13 | 1.174e-10 |
33 | CELLULAR RESPONSE TO NITROGEN COMPOUND | 17 | 505 | 1.21e-12 | 1.656e-10 |
34 | POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 21 | 876 | 1.175e-12 | 1.656e-10 |
35 | REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN | 9 | 68 | 1.935e-12 | 2.572e-10 |
36 | CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND | 20 | 799 | 2.084e-12 | 2.693e-10 |
37 | REGULATION OF RESPONSE TO CYTOKINE STIMULUS | 11 | 144 | 2.756e-12 | 3.466e-10 |
38 | POSITIVE REGULATION OF STAT CASCADE | 9 | 73 | 3.759e-12 | 4.485e-10 |
39 | POSITIVE REGULATION OF JAK STAT CASCADE | 9 | 73 | 3.759e-12 | 4.485e-10 |
40 | IMMUNE SYSTEM PROCESS | 29 | 1984 | 4.556e-12 | 5.3e-10 |
41 | NEGATIVE REGULATION OF CELL COMMUNICATION | 23 | 1192 | 6.613e-12 | 7.504e-10 |
42 | CELL ACTIVATION | 17 | 568 | 7.835e-12 | 8.68e-10 |
43 | RESPONSE TO GROWTH HORMONE | 7 | 30 | 9.028e-12 | 9.769e-10 |
44 | REGULATION OF CELL DEATH | 25 | 1472 | 9.789e-12 | 1.035e-09 |
45 | NEGATIVE REGULATION OF CELL DEATH | 20 | 872 | 1.02e-11 | 1.055e-09 |
46 | CELLULAR RESPONSE TO PEPTIDE | 13 | 274 | 1.067e-11 | 1.079e-09 |
47 | POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS | 25 | 1492 | 1.313e-11 | 1.275e-09 |
48 | NEGATIVE REGULATION OF RESPONSE TO STIMULUS | 24 | 1360 | 1.316e-11 | 1.275e-09 |
49 | NEGATIVE REGULATION OF PHOSPHORYLATION | 15 | 422 | 1.43e-11 | 1.358e-09 |
50 | POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 22 | 1135 | 1.983e-11 | 1.845e-09 |
51 | NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 15 | 437 | 2.342e-11 | 2.137e-09 |
52 | PROTEIN PHOSPHORYLATION | 20 | 944 | 4.243e-11 | 3.796e-09 |
53 | REGULATION OF DEFENSE RESPONSE | 18 | 759 | 7.942e-11 | 6.972e-09 |
54 | POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS | 19 | 867 | 8.183e-11 | 7.051e-09 |
55 | REGULATION OF CELL PROLIFERATION | 24 | 1496 | 9.581e-11 | 8.106e-09 |
56 | POSITIVE REGULATION OF CELL COMMUNICATION | 24 | 1532 | 1.564e-10 | 1.299e-08 |
57 | LYMPHOCYTE ACTIVATION | 13 | 342 | 1.682e-10 | 1.373e-08 |
58 | REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION | 11 | 213 | 1.927e-10 | 1.546e-08 |
59 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 20 | 1036 | 2.208e-10 | 1.712e-08 |
60 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 20 | 1036 | 2.208e-10 | 1.712e-08 |
61 | POSITIVE REGULATION OF CELL PROLIFERATION | 18 | 814 | 2.466e-10 | 1.881e-08 |
62 | REGULATION OF INNATE IMMUNE RESPONSE | 13 | 357 | 2.851e-10 | 2.14e-08 |
63 | POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS | 5 | 12 | 3.529e-10 | 2.606e-08 |
64 | PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS | 7 | 49 | 3.614e-10 | 2.628e-08 |
65 | REGULATION OF RESPONSE TO STRESS | 23 | 1468 | 4.28e-10 | 3.064e-08 |
66 | NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 15 | 541 | 4.593e-10 | 3.19e-08 |
67 | NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 15 | 541 | 4.593e-10 | 3.19e-08 |
68 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 26 | 1977 | 9.333e-10 | 6.294e-08 |
69 | PEPTIDYL TYROSINE MODIFICATION | 10 | 186 | 9.292e-10 | 6.294e-08 |
70 | NEGATIVE REGULATION OF KINASE ACTIVITY | 11 | 250 | 1.055e-09 | 7.015e-08 |
71 | JAK STAT CASCADE INVOLVED IN GROWTH HORMONE SIGNALING PATHWAY | 5 | 15 | 1.327e-09 | 8.697e-08 |
72 | LEUKOCYTE ACTIVATION | 13 | 414 | 1.731e-09 | 1.118e-07 |
73 | REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS | 5 | 17 | 2.72e-09 | 1.71e-07 |
74 | NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 15 | 616 | 2.707e-09 | 1.71e-07 |
75 | LYMPHOCYTE DIFFERENTIATION | 10 | 209 | 2.877e-09 | 1.785e-07 |
76 | PEPTIDYL AMINO ACID MODIFICATION | 17 | 841 | 3.315e-09 | 2.03e-07 |
77 | NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS | 19 | 1087 | 3.59e-09 | 2.169e-07 |
78 | RESPONSE TO ALCOHOL | 12 | 362 | 4.272e-09 | 2.548e-07 |
79 | POSITIVE REGULATION OF CYTOKINE PRODUCTION | 12 | 370 | 5.456e-09 | 3.214e-07 |
80 | REGULATION OF CYTOKINE PRODUCTION | 14 | 563 | 7.581e-09 | 4.355e-07 |
81 | POSITIVE REGULATION OF IMMUNE RESPONSE | 14 | 563 | 7.581e-09 | 4.355e-07 |
82 | REGULATION OF LEUKOCYTE DIFFERENTIATION | 10 | 232 | 7.844e-09 | 4.451e-07 |
83 | REGULATION OF HOMOTYPIC CELL CELL ADHESION | 11 | 307 | 9.021e-09 | 5.057e-07 |
84 | PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS | 8 | 120 | 9.182e-09 | 5.079e-07 |
85 | NEGATIVE REGULATION OF JAK STAT CASCADE | 6 | 44 | 9.388e-09 | 5.079e-07 |
86 | NEGATIVE REGULATION OF STAT CASCADE | 6 | 44 | 9.388e-09 | 5.079e-07 |
87 | POSITIVE REGULATION OF CELL ACTIVATION | 11 | 311 | 1.031e-08 | 5.516e-07 |
88 | REGULATION OF CELL ACTIVATION | 13 | 484 | 1.123e-08 | 5.94e-07 |
89 | IMMUNE EFFECTOR PROCESS | 13 | 486 | 1.18e-08 | 6.167e-07 |
90 | RESPONSE TO ORGANIC CYCLIC COMPOUND | 17 | 917 | 1.201e-08 | 6.206e-07 |
91 | INSULIN RECEPTOR SIGNALING PATHWAY | 7 | 80 | 1.227e-08 | 6.206e-07 |
92 | POSITIVE REGULATION OF CELL CELL ADHESION | 10 | 243 | 1.22e-08 | 6.206e-07 |
93 | POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS | 5 | 23 | 1.455e-08 | 7.281e-07 |
94 | LEUKOCYTE CELL CELL ADHESION | 10 | 255 | 1.929e-08 | 9.55e-07 |
95 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 23 | 1791 | 1.956e-08 | 9.579e-07 |
96 | LEUKOCYTE MIGRATION | 10 | 259 | 2.236e-08 | 1.084e-06 |
97 | PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 5 | 25 | 2.285e-08 | 1.096e-06 |
98 | NEGATIVE REGULATION OF TRANSFERASE ACTIVITY | 11 | 351 | 3.572e-08 | 1.696e-06 |
99 | RESPONSE TO INSULIN | 9 | 205 | 3.968e-08 | 1.865e-06 |
100 | RESPONSE TO LIPID | 16 | 888 | 5.197e-08 | 2.418e-06 |
101 | LIPID PHOSPHORYLATION | 7 | 99 | 5.456e-08 | 2.514e-06 |
102 | LEUKOCYTE DIFFERENTIATION | 10 | 292 | 6.912e-08 | 3.153e-06 |
103 | REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 12 | 470 | 7.63e-08 | 3.447e-06 |
104 | REGULATION OF CELL CELL ADHESION | 11 | 380 | 7.998e-08 | 3.578e-06 |
105 | REGULATION OF T CELL DIFFERENTIATION | 7 | 107 | 9.349e-08 | 4.143e-06 |
106 | POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION | 8 | 162 | 9.604e-08 | 4.216e-06 |
107 | REGULATION OF CELL DIFFERENTIATION | 20 | 1492 | 1.093e-07 | 4.753e-06 |
108 | NEGATIVE REGULATION OF MOLECULAR FUNCTION | 17 | 1079 | 1.28e-07 | 5.513e-06 |
109 | RESPONSE TO EXTERNAL STIMULUS | 22 | 1821 | 1.309e-07 | 5.589e-06 |
110 | GLUCOSE HOMEOSTASIS | 8 | 170 | 1.393e-07 | 5.736e-06 |
111 | REGULATION OF HEMOPOIESIS | 10 | 314 | 1.36e-07 | 5.736e-06 |
112 | NEGATIVE REGULATION OF CATALYTIC ACTIVITY | 15 | 829 | 1.384e-07 | 5.736e-06 |
113 | CARBOHYDRATE HOMEOSTASIS | 8 | 170 | 1.393e-07 | 5.736e-06 |
114 | POSITIVE REGULATION OF CATALYTIC ACTIVITY | 20 | 1518 | 1.449e-07 | 5.912e-06 |
115 | IMMUNE RESPONSE | 17 | 1100 | 1.685e-07 | 6.817e-06 |
116 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 19 | 1395 | 1.938e-07 | 7.774e-06 |
117 | REGULATION OF TYPE I INTERFERON MEDIATED SIGNALING PATHWAY | 5 | 39 | 2.384e-07 | 9.402e-06 |
118 | REGULATION OF CELL ADHESION | 13 | 629 | 2.38e-07 | 9.402e-06 |
119 | T CELL DIFFERENTIATION | 7 | 123 | 2.436e-07 | 9.526e-06 |
120 | REGULATION OF GROWTH | 13 | 633 | 2.558e-07 | 9.902e-06 |
121 | INOSITOL LIPID MEDIATED SIGNALING | 7 | 124 | 2.575e-07 | 9.902e-06 |
122 | POSITIVE REGULATION OF GLUCOSE TRANSPORT | 5 | 42 | 3.494e-07 | 1.333e-05 |
123 | PHOSPHATIDYLINOSITOL METABOLIC PROCESS | 8 | 193 | 3.681e-07 | 1.393e-05 |
124 | REGULATION OF LYMPHOCYTE DIFFERENTIATION | 7 | 132 | 3.943e-07 | 1.48e-05 |
125 | REGULATION OF MAPK CASCADE | 13 | 660 | 4.114e-07 | 1.531e-05 |
126 | NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY | 5 | 44 | 4.437e-07 | 1.638e-05 |
127 | REGULATION OF ERBB SIGNALING PATHWAY | 6 | 83 | 4.51e-07 | 1.652e-05 |
128 | POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION | 7 | 136 | 4.83e-07 | 1.756e-05 |
129 | SINGLE ORGANISM CELL ADHESION | 11 | 459 | 5.277e-07 | 1.903e-05 |
130 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 7 | 138 | 5.332e-07 | 1.909e-05 |
131 | REGULATION OF LEUKOCYTE PROLIFERATION | 8 | 206 | 6.039e-07 | 2.145e-05 |
132 | POSITIVE REGULATION OF CELL ADHESION | 10 | 376 | 7.121e-07 | 2.51e-05 |
133 | POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 9 | 289 | 7.293e-07 | 2.533e-05 |
134 | GLYCEROLIPID BIOSYNTHETIC PROCESS | 8 | 211 | 7.239e-07 | 2.533e-05 |
135 | NEGATIVE REGULATION OF MAPK CASCADE | 7 | 145 | 7.451e-07 | 2.568e-05 |
136 | RESPONSE TO ESTRADIOL | 7 | 146 | 7.805e-07 | 2.651e-05 |
137 | CELLULAR RESPONSE TO INSULIN STIMULUS | 7 | 146 | 7.805e-07 | 2.651e-05 |
138 | REGULATION OF T CELL PROLIFERATION | 7 | 147 | 8.173e-07 | 2.756e-05 |
139 | POSITIVE REGULATION OF KINASE ACTIVITY | 11 | 482 | 8.533e-07 | 2.856e-05 |
140 | RESPONSE TO ESTROGEN | 8 | 218 | 9.259e-07 | 3.077e-05 |
141 | CELL MOTILITY | 14 | 835 | 9.612e-07 | 3.128e-05 |
142 | LOCALIZATION OF CELL | 14 | 835 | 9.612e-07 | 3.128e-05 |
143 | CELLULAR RESPONSE TO INTERLEUKIN 6 | 4 | 22 | 9.596e-07 | 3.128e-05 |
144 | POSITIVE REGULATION OF T CELL PROLIFERATION | 6 | 95 | 1.005e-06 | 3.247e-05 |
145 | RESPONSE TO STEROID HORMONE | 11 | 497 | 1.151e-06 | 3.694e-05 |
146 | CELL CELL ADHESION | 12 | 608 | 1.189e-06 | 3.788e-05 |
147 | POSITIVE REGULATION OF GENE EXPRESSION | 20 | 1733 | 1.202e-06 | 3.804e-05 |
148 | EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 5 | 55 | 1.379e-06 | 4.337e-05 |
149 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 16 | 1142 | 1.533e-06 | 4.786e-05 |
150 | PHOSPHOLIPID BIOSYNTHETIC PROCESS | 8 | 235 | 1.626e-06 | 5.045e-05 |
151 | FAT CELL DIFFERENTIATION | 6 | 106 | 1.914e-06 | 5.897e-05 |
152 | RESPONSE TO INTERLEUKIN 6 | 4 | 26 | 1.941e-06 | 5.902e-05 |
153 | RESPONSE TO BIOTIC STIMULUS | 14 | 886 | 1.934e-06 | 5.902e-05 |
154 | REGULATION OF GLUCOSE IMPORT | 5 | 60 | 2.137e-06 | 6.456e-05 |
155 | RESPONSE TO VIRUS | 8 | 247 | 2.357e-06 | 7.076e-05 |
156 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 19 | 1672 | 3.02e-06 | 9.008e-05 |
157 | CELL PROLIFERATION | 12 | 672 | 3.352e-06 | 9.935e-05 |
158 | RESPONSE TO KETONE | 7 | 182 | 3.404e-06 | 0.0001002 |
159 | REGULATION OF MULTICELLULAR ORGANISM GROWTH | 5 | 66 | 3.44e-06 | 0.0001007 |
160 | RESPONSE TO TYPE I INTERFERON | 5 | 68 | 3.991e-06 | 0.0001161 |
161 | NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS | 4 | 31 | 4.031e-06 | 0.0001165 |
162 | CELLULAR RESPONSE TO INTERFERON GAMMA | 6 | 122 | 4.34e-06 | 0.0001246 |
163 | INTERFERON GAMMA MEDIATED SIGNALING PATHWAY | 5 | 70 | 4.608e-06 | 0.0001316 |
164 | TYROSINE PHOSPHORYLATION OF STAT PROTEIN | 3 | 10 | 4.841e-06 | 0.0001374 |
165 | IMMUNE SYSTEM DEVELOPMENT | 11 | 582 | 5.262e-06 | 0.0001484 |
166 | POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION | 6 | 131 | 6.546e-06 | 0.0001835 |
167 | POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY | 4 | 36 | 7.447e-06 | 0.0002075 |
168 | ERBB SIGNALING PATHWAY | 5 | 79 | 8.375e-06 | 0.000232 |
169 | LIPID MODIFICATION | 7 | 210 | 8.715e-06 | 0.0002399 |
170 | NATURAL KILLER CELL DIFFERENTIATION | 3 | 12 | 8.831e-06 | 0.0002417 |
171 | POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION | 5 | 80 | 8.909e-06 | 0.0002424 |
172 | POSITIVE REGULATION OF TRANSFERASE ACTIVITY | 11 | 616 | 8.997e-06 | 0.0002434 |
173 | GLYCEROPHOSPHOLIPID METABOLIC PROCESS | 8 | 297 | 9.146e-06 | 0.000246 |
174 | PLATELET ACTIVATION | 6 | 142 | 1.04e-05 | 0.0002781 |
175 | ORGAN REGENERATION | 5 | 83 | 1.067e-05 | 0.0002838 |
176 | RESPONSE TO INTERFERON GAMMA | 6 | 144 | 1.126e-05 | 0.0002978 |
177 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 4 | 40 | 1.143e-05 | 0.0002994 |
178 | ENERGY HOMEOSTASIS | 3 | 13 | 1.145e-05 | 0.0002994 |
179 | HOMEOSTATIC PROCESS | 16 | 1337 | 1.153e-05 | 0.0002998 |
180 | POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION | 5 | 88 | 1.421e-05 | 0.0003673 |
181 | REGULATION OF MAP KINASE ACTIVITY | 8 | 319 | 1.534e-05 | 0.0003901 |
182 | REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY | 4 | 43 | 1.532e-05 | 0.0003901 |
183 | ACUTE PHASE RESPONSE | 4 | 43 | 1.532e-05 | 0.0003901 |
184 | IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY | 8 | 323 | 1.678e-05 | 0.0004244 |
185 | NEGATIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION | 3 | 15 | 1.813e-05 | 0.0004535 |
186 | T CELL LINEAGE COMMITMENT | 3 | 15 | 1.813e-05 | 0.0004535 |
187 | DEFENSE RESPONSE | 15 | 1231 | 1.851e-05 | 0.0004606 |
188 | POSITIVE REGULATION OF CELL CYCLE | 8 | 332 | 2.045e-05 | 0.000506 |
189 | REGULATION OF CELL CYCLE | 13 | 949 | 2.185e-05 | 0.0005379 |
190 | REGULATION OF TYROSINE PHOSPHORYLATION OF STAT1 PROTEIN | 3 | 16 | 2.225e-05 | 0.000545 |
191 | POSITIVE REGULATION OF HEMOPOIESIS | 6 | 163 | 2.277e-05 | 0.0005548 |
192 | REGULATION OF LIPID KINASE ACTIVITY | 4 | 48 | 2.383e-05 | 0.0005776 |
193 | LOCOMOTION | 14 | 1114 | 2.63e-05 | 0.0006307 |
194 | REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION | 5 | 100 | 2.643e-05 | 0.0006307 |
195 | REGULATION OF GLUCOSE TRANSPORT | 5 | 100 | 2.643e-05 | 0.0006307 |
196 | MOVEMENT OF CELL OR SUBCELLULAR COMPONENT | 15 | 1275 | 2.792e-05 | 0.0006628 |
197 | NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE | 4 | 52 | 3.281e-05 | 0.000775 |
198 | GLYCEROLIPID METABOLIC PROCESS | 8 | 356 | 3.363e-05 | 0.0007904 |
199 | CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND | 9 | 465 | 3.399e-05 | 0.0007909 |
200 | HOMEOSTASIS OF NUMBER OF CELLS | 6 | 175 | 3.396e-05 | 0.0007909 |
201 | MAMMARY GLAND EPITHELIUM DEVELOPMENT | 4 | 53 | 3.54e-05 | 0.0008194 |
202 | PHOSPHOLIPID METABOLIC PROCESS | 8 | 364 | 3.937e-05 | 0.0009023 |
203 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 13 | 1004 | 3.929e-05 | 0.0009023 |
204 | RESPONSE TO GROWTH FACTOR | 9 | 475 | 4.011e-05 | 0.0009149 |
205 | REGULATION OF HYDROLASE ACTIVITY | 15 | 1327 | 4.434e-05 | 0.001006 |
206 | RESPONSE TO LEPTIN | 3 | 20 | 4.485e-05 | 0.001013 |
207 | CHEMICAL HOMEOSTASIS | 12 | 874 | 4.62e-05 | 0.001039 |
208 | POSITIVE REGULATION OF INFLAMMATORY RESPONSE | 5 | 113 | 4.758e-05 | 0.001064 |
209 | INNATE IMMUNE RESPONSE | 10 | 619 | 5.586e-05 | 0.001244 |
210 | MAMMARY GLAND DEVELOPMENT | 5 | 117 | 5.618e-05 | 0.001245 |
211 | POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION | 4 | 60 | 5.787e-05 | 0.00127 |
212 | LEUKOCYTE HOMEOSTASIS | 4 | 60 | 5.787e-05 | 0.00127 |
213 | REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION | 5 | 118 | 5.851e-05 | 0.001278 |
214 | REGULATION OF PHOSPHOLIPID METABOLIC PROCESS | 4 | 61 | 6.177e-05 | 0.001343 |
215 | REGULATION OF BODY FLUID LEVELS | 9 | 506 | 6.533e-05 | 0.001414 |
216 | REGULATION OF DEVELOPMENTAL GROWTH | 7 | 289 | 6.736e-05 | 0.001451 |
217 | REGULATION OF EPITHELIAL CELL DIFFERENTIATION | 5 | 122 | 6.858e-05 | 0.00147 |
218 | REGULATION OF METANEPHROS DEVELOPMENT | 3 | 23 | 6.915e-05 | 0.001476 |
219 | GLAND DEVELOPMENT | 8 | 395 | 6.99e-05 | 0.001485 |
220 | POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS | 7 | 296 | 7.826e-05 | 0.001655 |
221 | RESPONSE TO UV | 5 | 126 | 7.993e-05 | 0.001683 |
222 | CELLULAR RESPONSE TO UV | 4 | 66 | 8.419e-05 | 0.001765 |
223 | POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 5 | 129 | 8.935e-05 | 0.001864 |
224 | GROWTH | 8 | 410 | 9.06e-05 | 0.001882 |
225 | ORGAN GROWTH | 4 | 68 | 9.463e-05 | 0.001957 |
226 | EPITHELIUM DEVELOPMENT | 12 | 945 | 9.761e-05 | 0.00201 |
227 | REGULATION OF T HELPER CELL DIFFERENTIATION | 3 | 26 | 0.0001008 | 0.002065 |
228 | POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION | 4 | 70 | 0.000106 | 0.002154 |
229 | LIPID BIOSYNTHETIC PROCESS | 9 | 539 | 0.0001058 | 0.002154 |
230 | REGULATION OF IMMUNE EFFECTOR PROCESS | 8 | 424 | 0.0001143 | 0.002312 |
231 | ENERGY RESERVE METABOLIC PROCESS | 4 | 72 | 0.0001183 | 0.00238 |
232 | CELLULAR RESPONSE TO RADIATION | 5 | 137 | 0.0001187 | 0.00238 |
233 | NEGATIVE REGULATION OF MAP KINASE ACTIVITY | 4 | 73 | 0.0001248 | 0.002472 |
234 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 17 | 1805 | 0.0001238 | 0.002472 |
235 | ACUTE INFLAMMATORY RESPONSE | 4 | 73 | 0.0001248 | 0.002472 |
236 | POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE | 3 | 28 | 0.0001263 | 0.00248 |
237 | POSITIVE REGULATION OF ACTIVATED T CELL PROLIFERATION | 3 | 28 | 0.0001263 | 0.00248 |
238 | RESPONSE TO MOLECULE OF BACTERIAL ORIGIN | 7 | 321 | 0.0001296 | 0.002533 |
239 | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 4 | 74 | 0.0001316 | 0.002562 |
240 | CELLULAR GLUCOSE HOMEOSTASIS | 4 | 75 | 0.0001387 | 0.002688 |
241 | FC EPSILON RECEPTOR SIGNALING PATHWAY | 5 | 142 | 0.0001404 | 0.002712 |
242 | T CELL RECEPTOR SIGNALING PATHWAY | 5 | 146 | 0.00016 | 0.003075 |
243 | LIPID METABOLIC PROCESS | 13 | 1158 | 0.0001665 | 0.003188 |
244 | RESPONSE TO INTERLEUKIN 4 | 3 | 31 | 0.000172 | 0.003267 |
245 | ORGANOPHOSPHATE BIOSYNTHETIC PROCESS | 8 | 450 | 0.0001718 | 0.003267 |
246 | REGULATION OF ERK1 AND ERK2 CASCADE | 6 | 238 | 0.0001851 | 0.003501 |
247 | TISSUE DEVELOPMENT | 15 | 1518 | 0.0002005 | 0.003778 |
248 | FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 4 | 84 | 0.000215 | 0.004033 |
249 | REGULATION OF LEUKOCYTE MEDIATED IMMUNITY | 5 | 156 | 0.0002178 | 0.004054 |
250 | POSITIVE REGULATION OF IMMUNE EFFECTOR PROCESS | 5 | 156 | 0.0002178 | 0.004054 |
251 | BIOLOGICAL ADHESION | 12 | 1032 | 0.0002223 | 0.004122 |
252 | REGULATION OF PROTEIN DEACETYLATION | 3 | 34 | 0.0002273 | 0.00418 |
253 | PROTEIN KINASE B SIGNALING | 3 | 34 | 0.0002273 | 0.00418 |
254 | POSITIVE REGULATION OF MAPK CASCADE | 8 | 470 | 0.0002309 | 0.004217 |
255 | HORMONE MEDIATED SIGNALING PATHWAY | 5 | 158 | 0.0002311 | 0.004217 |
256 | POSITIVE REGULATION OF B CELL ACTIVATION | 4 | 86 | 0.0002354 | 0.004278 |
257 | REGENERATION | 5 | 161 | 0.0002521 | 0.004565 |
258 | POSITIVE REGULATION OF RESPONSE TO WOUNDING | 5 | 162 | 0.0002595 | 0.004679 |
259 | EPITHELIAL CELL PROLIFERATION | 4 | 89 | 0.0002685 | 0.004823 |
260 | T CELL SELECTION | 3 | 36 | 0.0002699 | 0.00483 |
261 | DEFENSE RESPONSE TO VIRUS | 5 | 164 | 0.0002746 | 0.004895 |
262 | POSITIVE REGULATION OF DEFENSE RESPONSE | 7 | 364 | 0.0002797 | 0.004967 |
263 | CELLULAR RESPONSE TO LIGHT STIMULUS | 4 | 91 | 0.0002923 | 0.005163 |
264 | REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION | 3 | 37 | 0.0002929 | 0.005163 |
265 | MORPHOGENESIS OF A BRANCHING STRUCTURE | 5 | 167 | 0.0002986 | 0.005242 |
266 | CELLULAR LIPID METABOLIC PROCESS | 11 | 913 | 0.0003097 | 0.005417 |
267 | REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION | 3 | 38 | 0.0003173 | 0.005488 |
268 | REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS | 3 | 38 | 0.0003173 | 0.005488 |
269 | CELLULAR RESPONSE TO ABIOTIC STIMULUS | 6 | 263 | 0.0003167 | 0.005488 |
270 | NEGATIVE REGULATION OF NEURON DEATH | 5 | 171 | 0.0003329 | 0.005738 |
271 | ERBB2 SIGNALING PATHWAY | 3 | 39 | 0.0003428 | 0.005822 |
272 | REGULATION OF CARBOHYDRATE METABOLIC PROCESS | 5 | 172 | 0.000342 | 0.005822 |
273 | ASTROCYTE DIFFERENTIATION | 3 | 39 | 0.0003428 | 0.005822 |
274 | EMBRYO IMPLANTATION | 3 | 39 | 0.0003428 | 0.005822 |
275 | FC GAMMA RECEPTOR SIGNALING PATHWAY | 4 | 95 | 0.0003446 | 0.00583 |
276 | REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 16 | 1784 | 0.0003574 | 0.006026 |
277 | REGULATION OF ACTIVATED T CELL PROLIFERATION | 3 | 40 | 0.0003697 | 0.006197 |
278 | GLIOGENESIS | 5 | 175 | 0.0003702 | 0.006197 |
279 | REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY | 4 | 97 | 0.0003731 | 0.006222 |
280 | POSITIVE REGULATION OF TRANSPORT | 11 | 936 | 0.0003827 | 0.006359 |
281 | LACTATION | 3 | 41 | 0.0003979 | 0.006589 |
282 | MYELOID LEUKOCYTE MIGRATION | 4 | 99 | 0.0004032 | 0.006653 |
283 | REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE | 4 | 101 | 0.000435 | 0.007152 |
284 | REGULATION OF LIPID METABOLIC PROCESS | 6 | 282 | 0.0004587 | 0.007436 |
285 | REGULATION OF GLYCOPROTEIN METABOLIC PROCESS | 3 | 43 | 0.0004583 | 0.007436 |
286 | MYELOID LEUKOCYTE MEDIATED IMMUNITY | 3 | 43 | 0.0004583 | 0.007436 |
287 | BETA CATENIN TCF COMPLEX ASSEMBLY | 3 | 43 | 0.0004583 | 0.007436 |
288 | NEGATIVE REGULATION OF HYDROLASE ACTIVITY | 7 | 397 | 0.0004711 | 0.00761 |
289 | POSITIVE REGULATION OF PROTEIN IMPORT | 4 | 104 | 0.0004861 | 0.007826 |
290 | RESPONSE TO BACTERIUM | 8 | 528 | 0.0005021 | 0.008056 |
291 | LUNG MORPHOGENESIS | 3 | 45 | 0.0005244 | 0.008385 |
292 | REGULATION OF GTPASE ACTIVITY | 9 | 673 | 0.0005454 | 0.008691 |
293 | REPRODUCTIVE SYSTEM DEVELOPMENT | 7 | 408 | 0.0005541 | 0.0088 |
294 | REGULATION OF ALPHA BETA T CELL DIFFERENTIATION | 3 | 46 | 0.0005596 | 0.008826 |
295 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 10 | 823 | 0.0005582 | 0.008826 |
296 | REGULATION OF INFLAMMATORY RESPONSE | 6 | 294 | 0.0005712 | 0.008979 |
297 | REGULATION OF IMMUNOGLOBULIN PRODUCTION | 3 | 47 | 0.0005962 | 0.009278 |
298 | RESPONSE TO RADIATION | 7 | 413 | 0.0005956 | 0.009278 |
299 | RESPONSE TO ANTIBIOTIC | 3 | 47 | 0.0005962 | 0.009278 |
300 | ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY | 5 | 195 | 0.0006063 | 0.009403 |
301 | REGULATION OF TYPE I INTERFERON PRODUCTION | 4 | 111 | 0.0006216 | 0.009609 |
302 | POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT1 PROTEIN | 2 | 11 | 0.0006507 | 0.009831 |
303 | OXALOACETATE METABOLIC PROCESS | 2 | 11 | 0.0006507 | 0.009831 |
304 | CREATINE METABOLIC PROCESS | 2 | 11 | 0.0006507 | 0.009831 |
305 | NEGATIVE REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 2 | 11 | 0.0006507 | 0.009831 |
306 | CD4 POSITIVE OR CD8 POSITIVE ALPHA BETA T CELL LINEAGE COMMITMENT | 2 | 11 | 0.0006507 | 0.009831 |
307 | REGULATION OF OSTEOBLAST DIFFERENTIATION | 4 | 112 | 0.0006429 | 0.009831 |
308 | POSITIVE REGULATION OF PROTEIN SUMOYLATION | 2 | 11 | 0.0006507 | 0.009831 |
309 | ORGAN MORPHOGENESIS | 10 | 841 | 0.0006601 | 0.00994 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | CYTOKINE RECEPTOR ACTIVITY | 20 | 89 | 1.275e-31 | 1.184e-28 |
2 | KINASE REGULATOR ACTIVITY | 15 | 186 | 8.78e-17 | 4.078e-14 |
3 | CYTOKINE RECEPTOR BINDING | 15 | 271 | 2.397e-14 | 7.423e-12 |
4 | RECEPTOR BINDING | 27 | 1476 | 1.773e-13 | 4.118e-11 |
5 | SIGNAL TRANSDUCER ACTIVITY | 28 | 1731 | 1.092e-12 | 2.028e-10 |
6 | KINASE INHIBITOR ACTIVITY | 9 | 89 | 2.355e-11 | 3.126e-09 |
7 | KINASE BINDING | 17 | 606 | 2.17e-11 | 3.126e-09 |
8 | CYTOKINE BINDING | 9 | 92 | 3.192e-11 | 3.707e-09 |
9 | ENZYME BINDING | 26 | 1737 | 5.492e-11 | 5.669e-09 |
10 | PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 8 | 70 | 1.184e-10 | 1.1e-08 |
11 | X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 7 | 43 | 1.379e-10 | 1.164e-08 |
12 | PHOSPHATIDYLINOSITOL KINASE ACTIVITY | 7 | 51 | 4.845e-10 | 3.751e-08 |
13 | MOLECULAR FUNCTION REGULATOR | 22 | 1353 | 5.761e-10 | 4.117e-08 |
14 | KINASE ACTIVITY | 17 | 842 | 3.375e-09 | 2.239e-07 |
15 | ENZYME REGULATOR ACTIVITY | 17 | 959 | 2.321e-08 | 1.437e-06 |
16 | SIGNALING RECEPTOR ACTIVITY | 20 | 1393 | 3.526e-08 | 2.047e-06 |
17 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 17 | 992 | 3.803e-08 | 2.078e-06 |
18 | INSULIN RECEPTOR SUBSTRATE BINDING | 4 | 11 | 4.457e-08 | 2.3e-06 |
19 | PHOSPHATASE BINDING | 8 | 162 | 9.604e-08 | 4.696e-06 |
20 | HORMONE RECEPTOR BINDING | 8 | 168 | 1.272e-07 | 5.907e-06 |
21 | PROTEIN PHOSPHATASE BINDING | 7 | 120 | 2.058e-07 | 9.102e-06 |
22 | RECEPTOR ACTIVITY | 20 | 1649 | 5.486e-07 | 2.317e-05 |
23 | GROWTH FACTOR BINDING | 6 | 123 | 4.55e-06 | 0.0001838 |
24 | ENZYME INHIBITOR ACTIVITY | 9 | 378 | 6.583e-06 | 0.0002548 |
25 | STEROID HORMONE RECEPTOR BINDING | 5 | 81 | 9.47e-06 | 0.0003519 |
26 | GLUCOCORTICOID RECEPTOR BINDING | 3 | 14 | 1.454e-05 | 0.0005195 |
27 | SUMO TRANSFERASE ACTIVITY | 3 | 15 | 1.813e-05 | 0.0006014 |
28 | INSULIN LIKE GROWTH FACTOR RECEPTOR BINDING | 3 | 15 | 1.813e-05 | 0.0006014 |
29 | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY | 3 | 16 | 2.225e-05 | 0.0007129 |
30 | RNA POLYMERASE II CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING | 4 | 53 | 3.54e-05 | 0.001096 |
31 | PROTEIN DIMERIZATION ACTIVITY | 14 | 1149 | 3.698e-05 | 0.001108 |
32 | PROTEIN KINASE ACTIVITY | 10 | 640 | 7.376e-05 | 0.002141 |
33 | TRANSCRIPTION FACTOR BINDING | 9 | 524 | 8.535e-05 | 0.002403 |
34 | GROWTH FACTOR RECEPTOR BINDING | 5 | 129 | 8.935e-05 | 0.002441 |
35 | PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY | 3 | 30 | 0.0001558 | 0.004135 |
36 | CORE PROMOTER BINDING | 5 | 152 | 0.000193 | 0.004981 |
37 | PEPTIDE HORMONE BINDING | 3 | 36 | 0.0002699 | 0.006776 |
38 | ANDROGEN RECEPTOR BINDING | 3 | 39 | 0.0003428 | 0.008381 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX | 7 | 20 | 3.534e-13 | 2.064e-10 |
2 | TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 10 | 237 | 9.616e-09 | 2.525e-06 |
3 | RECEPTOR COMPLEX | 11 | 327 | 1.729e-08 | 2.525e-06 |
4 | EXTRINSIC COMPONENT OF MEMBRANE | 10 | 252 | 1.725e-08 | 2.525e-06 |
5 | PLASMA MEMBRANE RECEPTOR COMPLEX | 8 | 175 | 1.741e-07 | 2.033e-05 |
6 | MEMBRANE PROTEIN COMPLEX | 16 | 1020 | 3.429e-07 | 3.338e-05 |
7 | TRANSFERASE COMPLEX | 12 | 703 | 5.314e-06 | 0.0004434 |
8 | INTRINSIC COMPONENT OF PLASMA MEMBRANE | 17 | 1649 | 4.015e-05 | 0.002931 |
9 | PLASMA MEMBRANE PROTEIN COMPLEX | 9 | 510 | 6.94e-05 | 0.004503 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | hsa04630_Jak.STAT_signaling_pathway | 70 | 155 | 1.625e-156 | 2.925e-154 | |
2 | hsa04151_PI3K_AKT_signaling_pathway | 25 | 351 | 1.714e-26 | 1.542e-24 | |
3 | hsa04380_Osteoclast_differentiation | 18 | 128 | 1.649e-24 | 9.895e-23 | |
4 | hsa04910_Insulin_signaling_pathway | 16 | 138 | 1.953e-20 | 8.79e-19 | |
5 | hsa04012_ErbB_signaling_pathway | 14 | 87 | 4.614e-20 | 1.661e-18 | |
6 | hsa04062_Chemokine_signaling_pathway | 16 | 189 | 3.376e-18 | 1.013e-16 | |
7 | hsa04650_Natural_killer_cell_mediated_cytotoxicity | 13 | 136 | 1.264e-15 | 2.98e-14 | |
8 | hsa04620_Toll.like_receptor_signaling_pathway | 12 | 102 | 1.324e-15 | 2.98e-14 | |
9 | hsa04662_B_cell_receptor_signaling_pathway | 11 | 75 | 1.741e-15 | 3.483e-14 | |
10 | hsa04660_T_cell_receptor_signaling_pathway | 12 | 108 | 2.69e-15 | 4.842e-14 | |
11 | hsa04664_Fc_epsilon_RI_signaling_pathway | 11 | 79 | 3.178e-15 | 5.201e-14 | |
12 | hsa04510_Focal_adhesion | 14 | 200 | 7.476e-15 | 1.121e-13 | |
13 | hsa04210_Apoptosis | 11 | 89 | 1.25e-14 | 1.731e-13 | |
14 | hsa04722_Neurotrophin_signaling_pathway | 12 | 127 | 1.971e-14 | 2.534e-13 | |
15 | hsa04973_Carbohydrate_digestion_and_absorption | 9 | 44 | 2.973e-14 | 3.568e-13 | |
16 | hsa04150_mTOR_signaling_pathway | 9 | 52 | 1.509e-13 | 1.698e-12 | |
17 | hsa04370_VEGF_signaling_pathway | 9 | 76 | 5.471e-12 | 5.793e-11 | |
18 | hsa04914_Progesterone.mediated_oocyte_maturation | 9 | 87 | 1.911e-11 | 1.911e-10 | |
19 | hsa04014_Ras_signaling_pathway | 12 | 236 | 3.204e-11 | 3.035e-10 | |
20 | hsa04666_Fc_gamma_R.mediated_phagocytosis | 9 | 95 | 4.282e-11 | 3.854e-10 | |
21 | hsa04960_Aldosterone.regulated_sodium_reabsorption | 7 | 42 | 1.157e-10 | 9.92e-10 | |
22 | hsa04670_Leukocyte_transendothelial_migration | 8 | 117 | 7.514e-09 | 6.148e-08 | |
23 | hsa04070_Phosphatidylinositol_signaling_system | 7 | 78 | 1.026e-08 | 8.03e-08 | |
24 | hsa04810_Regulation_of_actin_cytoskeleton | 9 | 214 | 5.742e-08 | 4.307e-07 | |
25 | hsa04920_Adipocytokine_signaling_pathway | 6 | 68 | 1.363e-07 | 9.812e-07 | |
26 | hsa04110_Cell_cycle | 6 | 128 | 5.728e-06 | 3.965e-05 | |
27 | hsa04120_Ubiquitin_mediated_proteolysis | 6 | 139 | 9.201e-06 | 6.134e-05 | |
28 | hsa04310_Wnt_signaling_pathway | 6 | 151 | 1.476e-05 | 9.49e-05 | |
29 | hsa04640_Hematopoietic_cell_lineage | 4 | 88 | 0.0002571 | 0.001596 | |
30 | hsa00562_Inositol_phosphate_metabolism | 3 | 57 | 0.001049 | 0.006296 | |
31 | hsa04115_p53_signaling_pathway | 3 | 69 | 0.001823 | 0.01059 | |
32 | hsa04390_Hippo_signaling_pathway | 4 | 154 | 0.00209 | 0.01175 | |
33 | hsa04010_MAPK_signaling_pathway | 5 | 268 | 0.002478 | 0.01352 | |
34 | hsa04350_TGF.beta_signaling_pathway | 3 | 85 | 0.003303 | 0.01749 | |
35 | hsa04320_Dorso.ventral_axis_formation | 2 | 25 | 0.003439 | 0.01769 | |
36 | hsa04330_Notch_signaling_pathway | 2 | 47 | 0.01179 | 0.05897 | |
37 | hsa04672_Intestinal_immune_network_for_IgA_production | 2 | 49 | 0.01277 | 0.06213 | |
38 | hsa04720_Long.term_potentiation | 2 | 70 | 0.02502 | 0.1185 | |
39 | hsa04520_Adherens_junction | 2 | 73 | 0.02705 | 0.1248 | |
40 | hsa04540_Gap_junction | 2 | 90 | 0.03969 | 0.1786 | |
41 | hsa04912_GnRH_signaling_pathway | 2 | 101 | 0.04885 | 0.2093 | |
42 | hsa04916_Melanogenesis | 2 | 101 | 0.04885 | 0.2093 | |
43 | hsa04530_Tight_junction | 2 | 133 | 0.07913 | 0.3312 | |
44 | hsa04144_Endocytosis | 2 | 203 | 0.1588 | 0.6495 |
Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
---|---|---|---|---|---|---|---|---|---|---|
1 | DHRS4-AS1 |
hsa-miR-1301-3p;hsa-miR-148b-5p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-362-5p;hsa-miR-501-5p;hsa-miR-589-3p;hsa-miR-93-3p | 11 | IL6ST | Sponge network | -0.646 | 0.01829 | -1.919 | 0 | 0.587 |
2 | HCG11 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-502-3p;hsa-miR-93-5p | 10 | AKT3 | Sponge network | -0.781 | 0 | -0.659 | 0.00047 | 0.574 |
3 | DHRS4-AS1 |
hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-582-5p;hsa-miR-589-3p | 10 | PIK3R1 | Sponge network | -0.646 | 0.01829 | -0.892 | 0 | 0.557 |
4 | LINC00261 | hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-188-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -1.194 | 0 | -0.892 | 0 | 0.513 |
5 | RP11-12A2.3 |
hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -4.779 | 0 | -0.892 | 0 | 0.489 |
6 | LINC01018 | hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -3.231 | 0 | -0.892 | 0 | 0.472 |
7 | LDLRAD4-AS1 |
hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -3.366 | 0 | -0.892 | 0 | 0.45 |
8 | RP11-119D9.1 | hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -2.765 | 0 | -0.892 | 0 | 0.418 |
9 | RP11-290F5.1 | hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p | 11 | PIK3R1 | Sponge network | -1.679 | 5.0E-5 | -0.892 | 0 | 0.402 |
10 | RP11-12A2.3 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-148b-5p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-93-3p | 10 | IL6ST | Sponge network | -4.779 | 0 | -1.919 | 0 | 0.381 |
11 | HCG11 |
hsa-miR-103a-3p;hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-421;hsa-miR-455-5p | 11 | IL6ST | Sponge network | -0.781 | 0 | -1.919 | 0 | 0.38 |
12 | ALDH1L1-AS2 | hsa-let-7e-5p;hsa-let-7i-5p;hsa-miR-125a-5p;hsa-miR-141-3p;hsa-miR-141-5p;hsa-miR-182-5p;hsa-miR-200a-3p;hsa-miR-21-5p;hsa-miR-23a-3p;hsa-miR-301a-3p | 10 | IL6R | Sponge network | 0.116 | 0.79006 | -0.197 | 0.38255 | 0.373 |
13 | LINC00238 | hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p | 12 | PIK3R1 | Sponge network | -4.997 | 0 | -0.892 | 0 | 0.369 |
14 | MAGI2-AS3 |
hsa-miR-106b-5p;hsa-miR-1266-5p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-589-3p;hsa-miR-616-5p;hsa-miR-9-5p;hsa-miR-92a-3p;hsa-miR-93-5p | 13 | CCND1 | Sponge network | -1.801 | 0 | -0.902 | 1.0E-5 | 0.359 |
15 | AC004862.6 | hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -2.202 | 0.00081 | -0.892 | 0 | 0.357 |
16 | RP11-407B7.1 | hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.818 | 0.00584 | -0.892 | 0 | 0.324 |
17 | RP11-166D19.1 |
hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-324-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -0.244 | 0.28835 | -0.892 | 0 | 0.32 |
18 | MAGI2-AS3 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-452-5p;hsa-miR-501-5p;hsa-miR-532-5p;hsa-miR-589-3p;hsa-miR-766-3p;hsa-miR-93-3p | 15 | IL6ST | Sponge network | -1.801 | 0 | -1.919 | 0 | 0.318 |
19 | RP11-7F17.3 | hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p | 11 | PIK3R1 | Sponge network | -0.873 | 0.00204 | -0.892 | 0 | 0.271 |
20 | SMIM2-AS1 |
hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p | 12 | PIK3R1 | Sponge network | -0.66 | 0.00587 | -0.892 | 0 | 0.27 |
21 | SMIM2-AS1 |
hsa-let-7e-5p;hsa-let-7i-5p;hsa-miR-125a-5p;hsa-miR-155-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-23a-3p;hsa-miR-301a-3p;hsa-miR-331-3p;hsa-miR-501-5p | 10 | IL6R | Sponge network | -0.66 | 0.00587 | -0.197 | 0.38255 | 0.261 |
22 | RP11-166D19.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1266-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-425-5p;hsa-miR-589-3p;hsa-miR-616-5p;hsa-miR-92a-3p;hsa-miR-942-5p | 16 | CCND1 | Sponge network | -0.244 | 0.28835 | -0.902 | 1.0E-5 | 0.253 |