Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7b-5p AARSD1 -0.96 0 0.39 0.0002 miRNAWalker2 validate -0.22 0 NA
2 hsa-let-7b-5p AATF -0.96 0 0.62 0 miRNAWalker2 validate -0.25 0 NA
3 hsa-let-7a-5p ABCB9 -0.33 0.00046 1.01 0 MirTarget; TargetScan -0.2 0.02597 NA
4 hsa-let-7c-5p ABCB9 -1.71 0 1.01 0 MirTarget -0.27 0 NA
5 hsa-let-7c-5p ABCC10 -1.71 0 1.42 0 MirTarget -0.3 0 NA
6 hsa-let-7a-5p ABCC5 -0.33 0.00046 1.23 0 TargetScan; miRNATAP -0.27 0 NA
7 hsa-let-7b-5p ABCC5 -0.96 0 1.23 0 miRNATAP -0.2 0 NA
8 hsa-let-7b-5p ABCF1 -0.96 0 0.32 1.0E-5 miRNAWalker2 validate -0.12 0 NA
9 hsa-let-7d-5p ABHD14B 0.05 0.70258 -0.88 0 MirTarget -0.16 0.00188 NA
10 hsa-let-7b-5p ACACA -0.96 0 0.78 0 miRNAWalker2 validate -0.25 0 NA
11 hsa-let-7a-5p ACAP3 -0.33 0.00046 0.47 1.0E-5 TargetScan -0.12 0.02739 NA
12 hsa-let-7d-5p ACVR1C 0.05 0.70258 -2.2 0 MirTarget; miRNATAP -0.47 0 NA
13 hsa-let-7d-5p ADRB2 0.05 0.70258 -1.63 0 MirTarget -0.53 0 NA
14 hsa-let-7b-5p ADRM1 -0.96 0 0.19 0.01952 miRNAWalker2 validate -0.16 0 NA
15 hsa-let-7a-5p ADSL -0.33 0.00046 0.46 0 miRNAWalker2 validate -0.17 0.00014 NA
16 hsa-let-7a-5p AEN -0.33 0.00046 0.28 0.01239 MirTarget; TargetScan -0.17 0.00498 NA
17 hsa-let-7b-5p AEN -0.96 0 0.28 0.01239 MirTarget -0.16 2.0E-5 NA
18 hsa-let-7d-5p AEN 0.05 0.70258 0.28 0.01239 MirTarget -0.13 0.00174 NA
19 hsa-let-7b-5p AFF2 -0.96 0 1.4 0.00046 MirTarget -0.39 0.00293 NA
20 hsa-let-7d-5p AFF2 0.05 0.70258 1.4 0.00046 MirTarget -0.33 0.02581 NA
21 hsa-let-7b-5p AGFG2 -0.96 0 -0.02 0.87061 miRNAWalker2 validate -0.17 1.0E-5 NA
22 hsa-let-7a-5p AIDA -0.33 0.00046 0.39 0 miRNAWalker2 validate -0.11 0.01007 NA
23 hsa-let-7a-5p AIFM1 -0.33 0.00046 -0.39 0.00049 TargetScan; miRNATAP -0.16 0.00689 NA
24 hsa-let-7d-5p AIFM1 0.05 0.70258 -0.39 0.00049 miRNATAP -0.23 0 NA
25 hsa-let-7d-5p AKAP6 0.05 0.70258 -0.97 0 MirTarget -0.3 1.0E-5 NA
26 hsa-let-7b-5p ALG3 -0.96 0 0.6 0 miRNAWalker2 validate -0.23 0 NA
27 hsa-let-7b-5p AMT -0.96 0 -0.85 0 MirTarget -0.16 0.00457 NA
28 hsa-let-7d-5p AMT 0.05 0.70258 -0.85 0 MirTarget -0.3 0 NA
29 hsa-let-7c-5p ANKRD49 -1.71 0 0.4 0 MirTarget -0.1 0 NA
30 hsa-let-7a-5p ANKRD52 -0.33 0.00046 1.46 0 TargetScan; mirMAP; miRNATAP -0.18 0.00575 NA
31 hsa-let-7b-5p ANKRD52 -0.96 0 1.46 0 miRNAWalker2 validate; mirMAP; miRNATAP -0.21 0 NA
32 hsa-let-7b-5p ANKZF1 -0.96 0 0.85 0 miRNAWalker2 validate -0.25 0 NA
33 hsa-let-7a-5p AP1S1 -0.33 0.00046 0.55 0 MirTarget; TargetScan; miRNATAP -0.23 1.0E-5 NA
34 hsa-let-7b-5p AP1S1 -0.96 0 0.55 0 MirTarget; miRNATAP -0.17 0 NA
35 hsa-let-7d-5p AP1S1 0.05 0.70258 0.55 0 MirTarget; miRNATAP -0.17 0 NA
36 hsa-let-7a-5p APC2 -0.33 0.00046 1.72 0 TargetScan -0.3 0.00538 NA
37 hsa-let-7b-5p APRT -0.96 0 0.19 0.12663 miRNAWalker2 validate -0.27 0 NA
38 hsa-let-7b-5p ARFIP2 -0.96 0 0.37 0 miRNAWalker2 validate -0.16 0 NA
39 hsa-let-7b-5p ARG2 -0.96 0 0.15 0.43591 MirTarget -0.18 0.00562 NA
40 hsa-let-7d-5p ARG2 0.05 0.70258 0.15 0.43591 MirTarget -0.24 0.00086 NA
41 hsa-let-7d-5p ARHGAP28 0.05 0.70258 0.59 0.03308 MirTarget; miRNATAP -0.21 0.03867 NA
42 hsa-let-7a-5p ARID3A -0.33 0.00046 1.53 0 TargetScan -0.63 0 NA
43 hsa-let-7b-5p ARID3A -0.96 0 1.53 0 miRNAWalker2 validate -0.38 1.0E-5 NA
44 hsa-let-7a-5p ARID3B -0.33 0.00046 0.46 0.00021 miRNAWalker2 validate; TargetScan; miRNATAP -0.17 0.01059 NA
45 hsa-let-7b-5p ARID3B -0.96 0 0.46 0.00021 miRNAWalker2 validate; miRNATAP -0.14 0.00075 NA
46 hsa-let-7b-5p ASNA1 -0.96 0 0.58 0 miRNAWalker2 validate -0.19 0 NA
47 hsa-let-7b-5p ASPSCR1 -0.96 0 0.72 1.0E-5 miRNAWalker2 validate -0.43 0 NA
48 hsa-let-7b-5p ATAD3B -0.96 0 0.76 0 miRNAWalker2 validate -0.29 0 NA
49 hsa-let-7a-5p ATG10 -0.33 0.00046 0.35 0.00052 MirTarget -0.21 6.0E-5 NA
50 hsa-let-7b-5p ATG10 -0.96 0 0.35 0.00052 MirTarget -0.2 0 NA
51 hsa-let-7d-5p ATG10 0.05 0.70258 0.35 0.00052 MirTarget -0.16 1.0E-5 NA
52 hsa-let-7a-5p ATG4B -0.33 0.00046 0.37 0 TargetScan -0.17 3.0E-5 NA
53 hsa-let-7b-5p ATG4B -0.96 0 0.37 0 miRNAWalker2 validate; miRNATAP -0.12 0 NA
54 hsa-let-7b-5p ATOX1 -0.96 0 0.43 0.00496 miRNAWalker2 validate -0.25 0 NA
55 hsa-let-7b-5p ATP6V0A1 -0.96 0 0.28 0.00395 miRNAWalker2 validate -0.12 0.00032 NA
56 hsa-let-7a-5p ATP6V1C1 -0.33 0.00046 0.88 0 TargetScan -0.28 1.0E-5 NA
57 hsa-let-7b-5p ATP6V1F -0.96 0 0.67 0 miRNAWalker2 validate -0.2 0 NA
58 hsa-let-7b-5p ATXN2L -0.96 0 0.61 0 miRNAWalker2 validate -0.1 3.0E-5 NA
59 hsa-let-7a-5p ATXN7L2 -0.33 0.00046 1.07 0 miRNATAP -0.18 0.0043 NA
60 hsa-let-7b-5p ATXN7L2 -0.96 0 1.07 0 miRNATAP -0.19 0 NA
61 hsa-let-7b-5p ATXN7L3 -0.96 0 0.7 0 miRNATAP -0.1 0.00048 NA
62 hsa-let-7b-5p AUP1 -0.96 0 0.15 0.05579 miRNAWalker2 validate -0.17 0 NA
63 hsa-let-7b-5p AURKA -0.96 0 2.71 0 miRNAWalker2 validate -0.44 0 NA
64 hsa-let-7b-5p AURKB -0.96 0 3.49 0 miRNAWalker2 validate -0.6 0 NA
65 hsa-let-7a-5p B3GAT3 -0.33 0.00046 0.5 1.0E-5 TargetScan -0.38 0 NA
66 hsa-let-7b-5p BBS7 -0.96 0 0.27 0.09013 miRNAWalker2 validate -0.1 0.04332 NA
67 hsa-let-7a-5p BCAT1 -0.33 0.00046 1.33 0 miRNAWalker2 validate; TargetScan -0.28 0.00571 NA
68 hsa-let-7b-5p BFSP1 -0.96 0 1.36 0 miRNAWalker2 validate -0.2 0.00047 NA
69 hsa-let-7b-5p BGLAP -0.96 0 0.57 0.00109 miRNAWalker2 validate -0.28 0 NA
70 hsa-let-7a-5p BIN3 -0.33 0.00046 -0.4 6.0E-5 TargetScan -0.12 0.0229 NA
71 hsa-let-7b-5p BIRC5 -0.96 0 4.5 0 miRNAWalker2 validate -0.71 0 NA
72 hsa-let-7a-5p BRI3BP -0.33 0.00046 0.53 0 mirMAP -0.19 0.00226 NA
73 hsa-let-7b-5p BRI3BP -0.96 0 0.53 0 mirMAP -0.16 3.0E-5 NA
74 hsa-let-7a-5p BZW2 -0.33 0.00046 0.58 0 MirTarget; TargetScan; miRNATAP -0.21 0.00015 NA
75 hsa-let-7b-5p BZW2 -0.96 0 0.58 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.2 0 NA
76 hsa-let-7c-5p BZW2 -1.71 0 0.58 0 MirTarget -0.2 0 NA
77 hsa-let-7b-5p C15orf41 -0.96 0 0.9 0 miRNATAP -0.14 0.00043 NA
78 hsa-let-7b-5p C22orf29 -0.96 0 1.09 0 mirMAP -0.1 0.00283 NA
79 hsa-let-7a-5p CACNA1E -0.33 0.00046 1.61 4.0E-5 TargetScan; miRNATAP -1.16 0 NA
80 hsa-let-7b-5p CACNA1E -0.96 0 1.61 4.0E-5 miRNATAP -0.58 1.0E-5 NA
81 hsa-let-7a-5p CACNB4 -0.33 0.00046 1.93 0 TargetScan; miRNATAP -0.32 0.04341 NA
82 hsa-let-7b-5p CACNB4 -0.96 0 1.93 0 miRNATAP -0.43 1.0E-5 NA
83 hsa-let-7d-5p CADM2 0.05 0.70258 -2.32 0 MirTarget; miRNATAP -0.51 0.00035 NA
84 hsa-let-7d-5p CALCOCO2 0.05 0.70258 -0.31 1.0E-5 miRNAWalker2 validate -0.12 1.0E-5 NA
85 hsa-let-7a-5p CANT1 -0.33 0.00046 0.65 0 TargetScan -0.15 0.00046 NA
86 hsa-let-7a-5p CAP1 -0.33 0.00046 0.04 0.49169 miRNATAP -0.1 0.00115 NA
87 hsa-let-7b-5p CASKIN1 -0.96 0 1.73 0 miRNATAP -0.37 0.00036 NA
88 hsa-let-7d-5p CBR4 0.05 0.70258 -1.38 0 miRNAWalker2 validate -0.22 6.0E-5 NA
89 hsa-let-7a-5p CBX2 -0.33 0.00046 2.25 0 TargetScan; miRNATAP -0.31 0.01532 NA
90 hsa-let-7b-5p CBX2 -0.96 0 2.25 0 miRNATAP -0.29 0.0003 NA
91 hsa-let-7c-5p CBX5 -1.71 0 0.35 0.00158 MirTarget -0.12 3.0E-5 NA
92 hsa-let-7c-5p CBX6 -1.71 0 -0.14 0.56236 miRNAWalker2 validate -0.15 0.01207 NA
93 hsa-let-7b-5p CCDC134 -0.96 0 0.72 0 miRNAWalker2 validate -0.14 0.00081 NA
94 hsa-let-7b-5p CCL16 -0.96 0 -1.6 0.00036 MirTarget -0.39 0.00879 NA
95 hsa-let-7a-5p CCL3 -0.33 0.00046 -1.83 0 TargetScan -0.29 0.01759 NA
96 hsa-let-7b-5p CCNA2 -0.96 0 3.37 0 miRNAWalker2 validate; miRTarBase -0.52 0 NA
97 hsa-let-7b-5p CCNB1 -0.96 0 3.16 0 miRNAWalker2 validate -0.54 0 NA
98 hsa-let-7a-5p CCNB2 -0.33 0.00046 4.24 0 miRNAWalker2 validate -0.45 0.00714 NA
99 hsa-let-7b-5p CCNB2 -0.96 0 4.24 0 miRNAWalker2 validate -0.59 0 NA
100 hsa-let-7c-5p CCNB2 -1.71 0 4.24 0 miRNAWalker2 validate -0.85 0 NA
101 hsa-let-7a-5p CCNF -0.33 0.00046 2.17 0 MirTarget; TargetScan -0.33 0.00114 NA
102 hsa-let-7b-5p CCNF -0.96 0 2.17 0 miRNAWalker2 validate; MirTarget -0.34 0 NA
103 hsa-let-7c-5p CCNF -1.71 0 2.17 0 miRNAWalker2 validate; MirTarget -0.5 0 NA
104 hsa-let-7b-5p CD2BP2 -0.96 0 0.56 0 miRNAWalker2 validate -0.15 0 NA
105 hsa-let-7b-5p CD99 -0.96 0 0.06 0.61503 miRNAWalker2 validate -0.14 0.00045 NA
106 hsa-let-7a-5p CDC25A -0.33 0.00046 1.92 0 MirTarget; TargetScan; miRNATAP -0.26 0.02869 NA
107 hsa-let-7b-5p CDC25A -0.96 0 1.92 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.37 0 NA
108 hsa-let-7c-5p CDC25A -1.71 0 1.92 0 MirTarget -0.52 0 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules
109 hsa-let-7a-5p CDC25B -0.33 0.00046 0.8 0 miRNAWalker2 validate -0.21 0.00571 NA
110 hsa-let-7a-5p CDC34 -0.33 0.00046 -0.1 0.33032 miRTarBase; MirTarget; TargetScan; miRNATAP -0.23 2.0E-5 NA
111 hsa-let-7b-5p CDC34 -0.96 0 -0.1 0.33032 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.00017 NA
112 hsa-let-7d-5p CDC34 0.05 0.70258 -0.1 0.33032 MirTarget; miRNATAP -0.1 0.00857 NA
113 hsa-let-7a-5p CDCA8 -0.33 0.00046 3.15 0 TargetScan -0.29 0.02597 NA
114 hsa-let-7b-5p CDCA8 -0.96 0 3.15 0 miRNAWalker2 validate -0.42 0 NA
115 hsa-let-7b-5p CDIPT -0.96 0 -0.02 0.81886 miRNAWalker2 validate -0.11 0.00035 NA
116 hsa-let-7b-5p CDK6 -0.96 0 -0.31 0.22057 miRNAWalker2 validate; miRTarBase -0.22 0.00756 NA
117 hsa-let-7c-5p CECR6 -1.71 0 0.39 0.03999 MirTarget -0.15 0.0024 NA
118 hsa-let-7d-5p CEP120 0.05 0.70258 -0.39 2.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0.00124 NA
119 hsa-let-7c-5p CEP135 -1.71 0 0.28 0.03781 MirTarget -0.13 0.00011 NA
120 hsa-let-7c-5p CERCAM -1.71 0 -0.12 0.64816 MirTarget -0.14 0.03365 NA
121 hsa-let-7d-5p CGNL1 0.05 0.70258 -0.69 0.00039 MirTarget; miRNATAP -0.16 0.0289 NA
122 hsa-let-7b-5p CHAF1A -0.96 0 1.47 0 miRNAWalker2 validate -0.21 0 NA
123 hsa-let-7b-5p CHD7 -0.96 0 0.37 0.00251 miRNAWalker2 validate -0.13 0.00098 NA
124 hsa-let-7b-5p CHMP2A -0.96 0 0.29 0.01082 miRNAWalker2 validate -0.17 0 NA
125 hsa-let-7b-5p CHRAC1 -0.96 0 0.33 0.00039 miRNAWalker2 validate -0.12 0.0001 NA
126 hsa-let-7a-5p CHRD -0.33 0.00046 -0.03 0.86098 MirTarget; TargetScan; miRNATAP -0.31 0.0027 NA
127 hsa-let-7b-5p CHRD -0.96 0 -0.03 0.86098 MirTarget; miRNATAP -0.19 0.00276 NA
128 hsa-let-7d-5p CHRD 0.05 0.70258 -0.03 0.86098 MirTarget; miRNATAP -0.27 0.00016 NA
129 hsa-let-7b-5p CIZ1 -0.96 0 0.66 0 miRNAWalker2 validate -0.15 0 NA
130 hsa-let-7b-5p CKAP2 -0.96 0 1.29 0 miRNAWalker2 validate -0.18 0.00023 NA
131 hsa-let-7b-5p CKS2 -0.96 0 1.22 0 miRNAWalker2 validate -0.3 0 NA
132 hsa-let-7b-5p CLDN12 -0.96 0 -0.37 0.00035 MirTarget; miRNATAP -0.1 0.00328 NA
133 hsa-let-7d-5p CLDN12 0.05 0.70258 -0.37 0.00035 MirTarget; miRNATAP -0.17 2.0E-5 NA
134 hsa-let-7b-5p CMC1 -0.96 0 0.29 0.00197 miRNAWalker2 validate -0.27 0 NA
135 hsa-let-7c-5p CNOT3 -1.71 0 0.58 0 miRNAWalker2 validate -0.14 0 NA
136 hsa-let-7b-5p COIL -0.96 0 0.38 0 miRNAWalker2 validate; miRNATAP -0.14 0 NA
137 hsa-let-7a-5p COL24A1 -0.33 0.00046 2.07 0 MirTarget; TargetScan -0.59 0.00301 NA
138 hsa-let-7b-5p COL24A1 -0.96 0 2.07 0 MirTarget -0.58 0 NA
139 hsa-let-7c-5p COL24A1 -1.71 0 2.07 0 MirTarget -0.32 0.00072 NA
140 hsa-let-7d-5p COL24A1 0.05 0.70258 2.07 0 MirTarget -0.61 2.0E-5 NA
141 hsa-let-7b-5p COL4A5 -0.96 0 0.06 0.88138 miRNATAP -0.31 0.02448 NA
142 hsa-let-7a-5p COL9A1 -0.33 0.00046 2.79 0 TargetScan -0.37 0.01712 NA
143 hsa-let-7b-5p COMMD9 -0.96 0 0.25 0.00305 miRNAWalker2 validate -0.17 0 NA
144 hsa-let-7a-5p COPZ1 -0.33 0.00046 0.35 0 miRNAWalker2 validate -0.23 0 NA
145 hsa-let-7b-5p COX7B -0.96 0 0.2 0.0881 miRNAWalker2 validate -0.16 3.0E-5 NA
146 hsa-let-7b-5p CPSF1 -0.96 0 0.75 0 miRNAWalker2 validate -0.19 0 NA
147 hsa-let-7b-5p CPSF3L -0.96 0 0.17 0.03017 miRNAWalker2 validate -0.16 0 NA
148 hsa-let-7a-5p CPSF4 -0.33 0.00046 0.78 0 TargetScan -0.27 0 NA
149 hsa-let-7a-5p CS -0.33 0.00046 0.63 0 miRNAWalker2 validate -0.1 0.02829 NA
150 hsa-let-7b-5p CS -0.96 0 0.63 0 miRNAWalker2 validate -0.12 3.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NCRNA METABOLIC PROCESS 60 533 2.055e-19 9.564e-16
2 AMIDE BIOSYNTHETIC PROCESS 52 507 2.977e-15 6.927e-12
3 RNA PROCESSING 69 835 4.875e-15 7.561e-12
4 NCRNA PROCESSING 44 386 1.052e-14 1.223e-11
5 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 47 440 1.497e-14 1.393e-11
6 PEPTIDE METABOLIC PROCESS 53 571 9.585e-14 7.433e-11
7 CELLULAR AMIDE METABOLIC PROCESS 60 727 3.625e-13 2.41e-10
8 RIBOSOME BIOGENESIS 35 308 6.581e-12 3.828e-09
9 ORGANONITROGEN COMPOUND BIOSYNTHETIC PROCESS 71 1024 9.775e-12 5.054e-09
10 MITOTIC CELL CYCLE 58 766 3.058e-11 1.423e-08
11 TRANSLATIONAL INITIATION 23 146 4.17e-11 1.764e-08
12 CELL CYCLE PROCESS 71 1081 1.138e-10 4.414e-08
13 RRNA METABOLIC PROCESS 29 255 4.25e-10 1.521e-07
14 CELL CYCLE 79 1316 6.624e-10 2.201e-07
15 MRNA METABOLIC PROCESS 46 611 4.51e-09 1.399e-06
16 CELL DIVISION 38 460 8.927e-09 2.596e-06
17 TRNA METABOLIC PROCESS 22 176 9.754e-09 2.67e-06
18 NEGATIVE REGULATION OF CELL CYCLE PROCESS 24 214 1.811e-08 4.681e-06
19 ESTABLISHMENT OF LOCALIZATION IN CELL 88 1676 4.104e-08 1.005e-05
20 NEGATIVE REGULATION OF CELL CYCLE 34 433 1.843e-07 4.289e-05
21 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 15 104 3.396e-07 7.183e-05
22 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 16 118 3.299e-07 7.183e-05
23 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 21 199 3.943e-07 7.976e-05
24 CELL CYCLE PHASE TRANSITION 24 255 4.984e-07 9.662e-05
25 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 16 123 5.861e-07 0.000101
26 MULTI ORGANISM METABOLIC PROCESS 17 138 5.749e-07 0.000101
27 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 46 720 5.791e-07 0.000101
28 ORGANONITROGEN COMPOUND METABOLIC PROCESS 88 1796 8.465e-07 0.0001407
29 MACROMOLECULE CATABOLIC PROCESS 54 926 1.035e-06 0.000166
30 CELL CYCLE CHECKPOINT 20 194 1.077e-06 0.000167
31 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 17 146 1.281e-06 0.0001923
32 TRNA AMINOACYLATION 10 52 2.153e-06 0.0002963
33 AMINO ACID ACTIVATION 10 52 2.153e-06 0.0002963
34 REGULATION OF CELL CYCLE 54 949 2.165e-06 0.0002963
35 NITROGEN COMPOUND TRANSPORT 35 507 2.457e-06 0.0003266
36 MITOTIC CELL CYCLE CHECKPOINT 16 139 3.049e-06 0.0003941
37 MACROMOLECULAR COMPLEX ASSEMBLY 71 1398 3.253e-06 0.0003983
38 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 23 264 3.239e-06 0.0003983
39 RNA CATABOLIC PROCESS 21 227 3.369e-06 0.000402
40 POSITIVE REGULATION OF CELL CYCLE PROCESS 22 247 3.689e-06 0.0004292
41 CELLULAR RESPONSE TO STRESS 77 1565 3.888e-06 0.0004413
42 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 50 873 4.38e-06 0.0004853
43 RIBONUCLEOPROTEIN COMPLEX SUBUNIT ORGANIZATION 19 199 6.202e-06 0.0006712
44 CELLULAR CATABOLIC PROCESS 67 1322 6.769e-06 0.0006999
45 MITOTIC DNA INTEGRITY CHECKPOINT 13 100 6.7e-06 0.0006999
46 REGULATION OF MITOTIC CELL CYCLE 32 468 8.067e-06 0.000816
47 MITOTIC NUCLEAR DIVISION 27 361 8.334e-06 0.0008251
48 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 22 263 1.011e-05 0.0009798
49 PROTEIN TARGETING TO MEMBRANE 16 157 1.469e-05 0.001395
50 REGULATION OF CELL CYCLE PROCESS 35 558 1.96e-05 0.001824
51 CELL CYCLE G1 S PHASE TRANSITION 13 111 2.113e-05 0.001891
52 G1 S TRANSITION OF MITOTIC CELL CYCLE 13 111 2.113e-05 0.001891
53 DNA INTEGRITY CHECKPOINT 15 146 2.454e-05 0.002154
54 INTERSPECIES INTERACTION BETWEEN ORGANISMS 39 662 2.734e-05 0.002313
55 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 39 662 2.734e-05 0.002313
56 CATABOLIC PROCESS 81 1773 3.215e-05 0.002672
57 POSITIVE REGULATION OF CELL CYCLE ARREST 11 85 3.556e-05 0.002902
58 REGULATION OF PROTEIN CATABOLIC PROCESS 27 393 3.76e-05 0.003017
59 POSITIVE REGULATION OF CATABOLIC PROCESS 27 395 4.104e-05 0.003237
60 POSITIVE REGULATION OF CELL CYCLE 24 332 4.528e-05 0.003512
61 G1 DNA DAMAGE CHECKPOINT 10 73 4.887e-05 0.003726
62 PROTEASOMAL PROTEIN CATABOLIC PROCESS 21 271 4.964e-05 0.003726
63 DNA METABOLIC PROCESS 42 758 5.554e-05 0.004102
64 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 29 448 5.759e-05 0.004187
65 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 25 361 6.364e-05 0.004556
66 ESTABLISHMENT OF PROTEIN LOCALIZATION 67 1423 6.825e-05 0.004811
67 MRNA PROCESSING 28 432 7.532e-05 0.005154
68 REGULATION OF CELL CYCLE PHASE TRANSITION 23 321 7.424e-05 0.005154
69 CELLULAR RESPONSE TO OXYGEN LEVELS 14 143 7.723e-05 0.005208
70 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 13 127 8.76e-05 0.005823
71 CELLULAR MACROMOLECULAR COMPLEX ASSEMBLY 40 727 9.696e-05 0.006355
72 PROTEIN UBIQUITINATION 36 629 9.955e-05 0.006433
73 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 11 96 0.0001102 0.006926
74 REGULATION OF CATABOLIC PROCESS 40 731 0.0001089 0.006926
75 VIRAL LIFE CYCLE 21 290 0.0001301 0.008074
76 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 11 98 0.0001328 0.008131
77 ORGANELLE FISSION 30 496 0.0001453 0.008778
78 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 27 427 0.0001512 0.009022
79 MITOCHONDRION ORGANIZATION 34 594 0.0001543 0.009088
80 PROTEIN TARGETING 26 406 0.0001632 0.009494
NumGOOverlapSizeP ValueAdj. P Value
1 RNA BINDING 114 1598 1.438e-19 1.336e-16
2 POLY A RNA BINDING 86 1170 1.582e-15 7.351e-13
3 STRUCTURAL CONSTITUENT OF RIBOSOME 27 212 1.326e-10 4.106e-08
4 LIGASE ACTIVITY 31 406 1.168e-06 0.0002713
5 RIBONUCLEOTIDE BINDING 88 1860 3.557e-06 0.0006608
6 NUCLEOTIDYLTRANSFERASE ACTIVITY 15 131 6.595e-06 0.001021
7 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 47 820 8.401e-06 0.001115
8 STRUCTURAL MOLECULE ACTIVITY 43 732 1.135e-05 0.001318
9 LIGASE ACTIVITY FORMING CARBON OXYGEN BONDS 8 44 3.488e-05 0.00324
10 RNA POLYMERASE ACTIVITY 8 44 3.488e-05 0.00324
11 ADENYL NUCLEOTIDE BINDING 71 1514 4.62e-05 0.003902
12 TRANSLATION REGULATOR ACTIVITY 7 35 5.702e-05 0.004414
13 ATPASE ACTIVITY COUPLED 22 313 0.0001395 0.009971
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOPROTEIN COMPLEX 61 721 7.597e-14 4.437e-11
2 NUCLEOLUS 59 848 5.662e-10 1.653e-07
3 RIBOSOMAL SUBUNIT 22 163 2.289e-09 4.456e-07
4 RIBOSOME 25 226 1.209e-08 1.443e-06
5 MITOCHONDRION 88 1633 1.235e-08 1.443e-06
6 MITOCHONDRIAL MATRIX 33 412 1.772e-07 1.499e-05
7 CYTOSOLIC RIBOSOME 16 113 1.796e-07 1.499e-05
8 MITOCHONDRIAL PART 55 953 1.126e-06 8.22e-05
9 SMALL RIBOSOMAL SUBUNIT 11 68 3.994e-06 0.0002592
10 CHROMOSOME 47 880 4.964e-05 0.002899
11 LARGE RIBOSOMAL SUBUNIT 11 95 0.0001001 0.004534
12 TRANSFERASE COMPLEX 39 703 9.966e-05 0.004534
13 ENVELOPE 54 1090 0.0001009 0.004534
14 NUCLEOPLASM PART 39 708 0.0001155 0.00482
15 HETEROCHROMATIN 9 67 0.0001354 0.005273
16 PCG PROTEIN COMPLEX 7 43 0.0002233 0.008152
17 CYTOSOLIC SMALL RIBOSOMAL SUBUNIT 7 44 0.000259 0.008897
18 CYTOSOLIC PART 17 223 0.0003067 0.00995

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03010_Ribosome 15 92 6.436e-08 1.159e-05
2 hsa00240_Pyrimidine_metabolism 15 99 1.753e-07 1.578e-05
3 hsa00230_Purine_metabolism 17 162 5.388e-06 0.0003233
4 hsa04110_Cell_cycle 14 128 2.252e-05 0.001013
5 hsa03020_RNA_polymerase 6 29 0.0001603 0.00577
6 hsa00970_Aminoacyl.tRNA_biosynthesis 7 63 0.002324 0.06971
7 hsa03410_Base_excision_repair 5 34 0.00286 0.07353
8 hsa03030_DNA_replication 5 36 0.003694 0.08311
9 hsa03013_RNA_transport 11 152 0.005039 0.1008
10 hsa03040_Spliceosome 9 128 0.01273 0.2291
11 hsa00670_One_carbon_pool_by_folate 3 18 0.01451 0.2374
12 hsa04540_Gap_junction 7 90 0.01609 0.2413
13 hsa03008_Ribosome_biogenesis_in_eukaryotes 6 81 0.03085 0.4272
14 hsa04144_Endocytosis 11 203 0.03618 0.4652
15 hsa04914_Progesterone.mediated_oocyte_maturation 6 87 0.0416 0.4828
16 hsa04966_Collecting_duct_acid_secretion 3 27 0.04292 0.4828
17 hsa04115_p53_signaling_pathway 5 69 0.05069 0.5097
18 hsa04120_Ubiquitin_mediated_proteolysis 8 139 0.05097 0.5097
19 hsa03450_Non.homologous_end.joining 2 14 0.06124 0.5802
20 hsa00900_Terpenoid_backbone_biosynthesis 2 15 0.06934 0.624
21 hsa00564_Glycerophospholipid_metabolism 5 80 0.08417 0.7052
22 hsa04360_Axon_guidance 7 130 0.08619 0.7052
23 hsa04660_T_cell_receptor_signaling_pathway 6 108 0.09599 0.7512
24 hsa04012_ErbB_signaling_pathway 5 87 0.1103 0.7948
25 hsa00620_Pyruvate_metabolism 3 40 0.1104 0.7948
26 hsa04114_Oocyte_meiosis 6 114 0.1163 0.8051
27 hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate 2 22 0.1338 0.8759
28 hsa02010_ABC_transporters 3 44 0.1363 0.8759
29 hsa04010_MAPK_signaling_pathway 11 268 0.1614 0.9534
30 hsa04145_Phagosome 7 156 0.1715 0.9534
31 hsa04810_Regulation_of_actin_cytoskeleton 9 214 0.1743 0.9534
32 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 2 26 0.1748 0.9534
33 hsa04370_VEGF_signaling_pathway 4 76 0.181 0.9585
34 hsa04530_Tight_junction 6 133 0.1928 0.9641
35 hsa04664_Fc_epsilon_RI_signaling_pathway 4 79 0.1988 0.9672
36 hsa00330_Arginine_and_proline_metabolism 3 54 0.2082 0.986
37 hsa00020_Citrate_cycle_.TCA_cycle. 2 30 0.2174 0.9895
38 hsa04141_Protein_processing_in_endoplasmic_reticulum 7 168 0.2199 0.9895
39 hsa00260_Glycine._serine_and_threonine_metabolism 2 32 0.2391 1
40 hsa00590_Arachidonic_acid_metabolism 3 59 0.2468 1
41 hsa04140_Regulation_of_autophagy 2 34 0.2609 1
42 hsa04142_Lysosome 5 121 0.278 1
43 hsa04062_Chemokine_signaling_pathway 7 189 0.3139 1
44 hsa04920_Adipocytokine_signaling_pathway 3 68 0.3184 1
45 hsa03320_PPAR_signaling_pathway 3 70 0.3344 1
46 hsa04720_Long.term_potentiation 3 70 0.3344 1
47 hsa04730_Long.term_depression 3 70 0.3344 1
48 hsa04916_Melanogenesis 4 101 0.34 1
49 hsa00280_Valine._leucine_and_isoleucine_degradation 2 44 0.3686 1
50 hsa00310_Lysine_degradation 2 44 0.3686 1
51 hsa04662_B_cell_receptor_signaling_pathway 3 75 0.3744 1
52 hsa04910_Insulin_signaling_pathway 5 138 0.3756 1
53 hsa03420_Nucleotide_excision_repair 2 45 0.3791 1
54 hsa04146_Peroxisome 3 79 0.406 1
55 hsa00510_N.Glycan_biosynthesis 2 49 0.4202 1
56 hsa00480_Glutathione_metabolism 2 50 0.4303 1
57 hsa03015_mRNA_surveillance_pathway 3 83 0.4372 1
58 hsa00983_Drug_metabolism_._other_enzymes 2 52 0.4502 1
59 hsa04350_TGF.beta_signaling_pathway 3 85 0.4525 1
60 hsa04390_Hippo_signaling_pathway 5 154 0.4675 1
61 hsa04623_Cytosolic_DNA.sensing_pathway 2 56 0.4887 1
62 hsa04722_Neurotrophin_signaling_pathway 4 127 0.5089 1
63 hsa00190_Oxidative_phosphorylation 4 132 0.5393 1
64 hsa04912_GnRH_signaling_pathway 3 101 0.5679 1
65 hsa00010_Glycolysis_._Gluconeogenesis 2 65 0.5689 1
66 hsa04151_PI3K_AKT_signaling_pathway 10 351 0.5742 1
67 hsa04620_Toll.like_receptor_signaling_pathway 3 102 0.5746 1
68 hsa03018_RNA_degradation 2 71 0.6171 1
69 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.6171 1
70 hsa04260_Cardiac_muscle_contraction 2 77 0.6611 1
71 hsa04612_Antigen_processing_and_presentation 2 78 0.668 1
72 hsa04974_Protein_digestion_and_absorption 2 81 0.6881 1
73 hsa04014_Ras_signaling_pathway 6 236 0.6888 1
74 hsa04210_Apoptosis 2 89 0.7368 1
75 hsa04650_Natural_killer_cell_mediated_cytotoxicity 3 136 0.7619 1
76 hsa04020_Calcium_signaling_pathway 4 177 0.7621 1
77 hsa04310_Wnt_signaling_pathway 3 151 0.8203 1
78 hsa04510_Focal_adhesion 4 200 0.8384 1
79 hsa04670_Leukocyte_transendothelial_migration 2 117 0.8591 1
80 hsa04514_Cell_adhesion_molecules_.CAMs. 2 136 0.9098 1

Quest ID: cc84f8f87fdf237a9ee321604515a69b