Explanation
This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
miRNA-gene regulations
| Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | hsa-let-7a-3p | ACTL6A | 0.17 | 0.43183 | 0.81 | 0 | MirTarget | -0.13 | 0.00031 | NA | |
| 2 | hsa-let-7a-3p | ACTR3 | 0.17 | 0.43183 | 0.28 | 0.01178 | MirTarget; miRNATAP | -0.12 | 2.0E-5 | NA | |
| 3 | hsa-let-7a-5p | AKT2 | -1.37 | 0 | 0.16 | 0.1135 | TargetScan | -0.12 | 0 | NA | |
| 4 | hsa-miR-29a-3p | AKT2 | 0.1 | 0.5732 | 0.16 | 0.1135 | MirTarget | -0.1 | 4.0E-5 | 24076586 | Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis |
| 5 | hsa-miR-106b-5p | AKT3 | 1.47 | 0 | -1.44 | 0 | miRNATAP | -0.16 | 0.00426 | NA | |
| 6 | hsa-miR-107 | AKT3 | 0.66 | 0 | -1.44 | 0 | PITA; miRanda | -0.26 | 0.0031 | NA | |
| 7 | hsa-miR-146b-5p | AKT3 | 1.09 | 1.0E-5 | -1.44 | 0 | miRNAWalker2 validate | -0.15 | 0.00189 | NA | |
| 8 | hsa-miR-15a-5p | AKT3 | 1.63 | 0 | -1.44 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.41 | 0 | NA | |
| 9 | hsa-miR-16-5p | AKT3 | 0.75 | 0 | -1.44 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.27 | 0.0001 | NA | |
| 10 | hsa-miR-17-3p | AKT3 | 1.37 | 0 | -1.44 | 0 | miRNATAP | -0.15 | 0.01027 | NA | |
| 11 | hsa-miR-17-5p | AKT3 | 2.07 | 0 | -1.44 | 0 | TargetScan; miRNATAP | -0.22 | 0 | NA | |
| 12 | hsa-miR-181a-5p | AKT3 | -0.38 | 0.05621 | -1.44 | 0 | miRNATAP | -0.23 | 9.0E-5 | NA | |
| 13 | hsa-miR-181b-5p | AKT3 | 0.67 | 0.00024 | -1.44 | 0 | miRNATAP | -0.37 | 0 | NA | |
| 14 | hsa-miR-20a-5p | AKT3 | 2.65 | 0 | -1.44 | 0 | miRNATAP | -0.24 | 0 | NA | |
| 15 | hsa-miR-22-3p | AKT3 | 1.43 | 0 | -1.44 | 0 | miRNATAP | -0.26 | 0.00109 | NA | |
| 16 | hsa-miR-28-3p | AKT3 | 0.39 | 0.00778 | -1.44 | 0 | miRNATAP | -0.2 | 0.01226 | NA | |
| 17 | hsa-miR-29a-3p | AKT3 | 0.1 | 0.5732 | -1.44 | 0 | miRNATAP | -0.15 | 0.02016 | NA | |
| 18 | hsa-miR-29b-2-5p | AKT3 | 0.35 | 0.19484 | -1.44 | 0 | mirMAP | -0.18 | 2.0E-5 | NA | |
| 19 | hsa-miR-29b-3p | AKT3 | 3.11 | 0 | -1.44 | 0 | miRNATAP | -0.27 | 0 | 26512921 | MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 |
| 20 | hsa-miR-3065-5p | AKT3 | 0.65 | 0.09995 | -1.44 | 0 | mirMAP | -0.18 | 0 | NA | |
| 21 | hsa-miR-335-3p | AKT3 | 1.51 | 0 | -1.44 | 0 | mirMAP | -0.13 | 0.01067 | NA | |
| 22 | hsa-miR-362-5p | AKT3 | 0.66 | 0.02433 | -1.44 | 0 | PITA; TargetScan; miRNATAP | -0.23 | 0 | NA | |
| 23 | hsa-miR-542-3p | AKT3 | 1.62 | 0 | -1.44 | 0 | miRanda | -0.19 | 1.0E-5 | NA | |
| 24 | hsa-miR-93-5p | AKT3 | 1.51 | 0 | -1.44 | 0 | miRNATAP | -0.25 | 0 | NA | |
| 25 | hsa-let-7a-3p | ARL1 | 0.17 | 0.43183 | 0.22 | 0.06171 | miRNATAP | -0.11 | 0.00026 | NA | |
| 26 | hsa-let-7a-3p | ARL5A | 0.17 | 0.43183 | -0.17 | 0.1629 | MirTarget; mirMAP | -0.11 | 0.00015 | NA | |
| 27 | hsa-let-7a-3p | ASPH | 0.17 | 0.43183 | 0.49 | 0.08366 | mirMAP | -0.15 | 0.02505 | NA | |
| 28 | hsa-let-7a-3p | ASXL2 | 0.17 | 0.43183 | -0.3 | 0.12837 | mirMAP; miRNATAP | -0.14 | 0.00544 | NA | |
| 29 | hsa-let-7a-3p | ATAD5 | 0.17 | 0.43183 | 1.78 | 0 | MirTarget | -0.13 | 0.02804 | NA | |
| 30 | hsa-let-7a-3p | ATE1 | 0.17 | 0.43183 | -0.47 | 0.01177 | mirMAP | -0.15 | 0.00107 | NA | |
| 31 | hsa-let-7a-3p | ATF1 | 0.17 | 0.43183 | -0.1 | 0.43169 | MirTarget | -0.15 | 0 | NA | |
| 32 | hsa-let-7a-3p | ATF2 | 0.17 | 0.43183 | 0.01 | 0.93689 | MirTarget; mirMAP; miRNATAP | -0.13 | 0.0001 | NA | |
| 33 | hsa-let-7a-3p | ATP13A3 | 0.17 | 0.43183 | 0.41 | 0.00634 | mirMAP | -0.13 | 0.00056 | NA | |
| 34 | hsa-let-7a-3p | ATP2B1 | 0.17 | 0.43183 | -0.52 | 0.00592 | MirTarget; miRNATAP | -0.1 | 0.02775 | NA | |
| 35 | hsa-let-7a-3p | BACH1 | 0.17 | 0.43183 | -0.38 | 0.00633 | MirTarget; mirMAP | -0.12 | 0.00025 | NA | |
| 36 | hsa-let-7a-3p | BAG4 | 0.17 | 0.43183 | -0.09 | 0.6048 | mirMAP | -0.15 | 0.00045 | NA | |
| 37 | hsa-let-7a-3p | BMP2K | 0.17 | 0.43183 | -0.41 | 0.01747 | mirMAP | -0.1 | 0.01612 | NA | |
| 38 | hsa-let-7a-3p | BRIP1 | 0.17 | 0.43183 | 2.42 | 0 | MirTarget | -0.24 | 0.0016 | NA | |
| 39 | hsa-let-7a-3p | BST1 | 0.17 | 0.43183 | -1.69 | 0 | MirTarget | -0.15 | 0.01114 | NA | |
| 40 | hsa-let-7a-3p | C1QBP | 0.17 | 0.43183 | 0.43 | 0.00668 | MirTarget | -0.12 | 0.00264 | NA | |
| 41 | hsa-let-7a-3p | C2orf49 | 0.17 | 0.43183 | 0.44 | 0.00033 | mirMAP | -0.13 | 1.0E-5 | NA | |
| 42 | hsa-let-7a-3p | C4orf32 | 0.17 | 0.43183 | -1.32 | 0 | mirMAP | -0.12 | 0.00913 | NA | |
| 43 | hsa-let-7a-3p | CACNA2D1 | 0.17 | 0.43183 | -1.27 | 0.00469 | mirMAP | -0.25 | 0.02505 | NA | |
| 44 | hsa-let-7a-3p | CALCB | 0.17 | 0.43183 | 0.77 | 0.21301 | mirMAP | -0.35 | 0.02089 | NA | |
| 45 | hsa-let-7a-3p | CAND1 | 0.17 | 0.43183 | 0.38 | 0.00711 | MirTarget; mirMAP | -0.11 | 0.00156 | NA | |
| 46 | hsa-let-7a-3p | CAPZA2 | 0.17 | 0.43183 | -0.44 | 0.00975 | MirTarget | -0.18 | 2.0E-5 | NA | |
| 47 | hsa-let-7a-3p | CCNA2 | 0.17 | 0.43183 | 2.69 | 0 | MirTarget | -0.23 | 0.00207 | NA | |
| 48 | hsa-let-7a-3p | CCNE2 | 0.17 | 0.43183 | 2.15 | 0 | mirMAP | -0.22 | 0.00307 | NA | |
| 49 | hsa-let-7a-3p | CEP76 | 0.17 | 0.43183 | 0.44 | 0.0025 | MirTarget | -0.15 | 3.0E-5 | NA | |
| 50 | hsa-miR-106b-5p | CHP2 | 1.47 | 0 | -0.7 | 0.27547 | MirTarget | -0.29 | 0.04606 | NA | |
| 51 | hsa-miR-582-5p | CHP2 | 1.08 | 0.00149 | -0.7 | 0.27547 | miRNATAP | -0.17 | 0.04861 | NA | |
| 52 | hsa-let-7a-3p | COL4A1 | 0.17 | 0.43183 | -0.17 | 0.44496 | miRNATAP | -0.12 | 0.03103 | NA | |
| 53 | hsa-let-7a-3p | CORO1C | 0.17 | 0.43183 | -1.11 | 0 | MirTarget; miRNATAP | -0.14 | 0.00015 | NA | |
| 54 | hsa-let-7a-3p | CPD | 0.17 | 0.43183 | 0.91 | 9.0E-5 | mirMAP; miRNATAP | -0.23 | 7.0E-5 | NA | |
| 55 | hsa-let-7a-3p | CXADR | 0.17 | 0.43183 | -0.22 | 0.35808 | miRNATAP | -0.16 | 0.00611 | NA | |
| 56 | hsa-let-7a-3p | CYP1B1 | 0.17 | 0.43183 | -0.3 | 0.28599 | mirMAP | -0.14 | 0.03711 | NA | |
| 57 | hsa-let-7a-3p | DCUN1D1 | 0.17 | 0.43183 | 0.14 | 0.30132 | mirMAP | -0.12 | 0.00032 | NA | |
| 58 | hsa-let-7a-3p | DENND1B | 0.17 | 0.43183 | 0.31 | 0.07298 | mirMAP | -0.12 | 0.00576 | NA | |
| 59 | hsa-let-7a-3p | DEPDC1 | 0.17 | 0.43183 | 3.45 | 0 | mirMAP | -0.31 | 0.00111 | NA | |
| 60 | hsa-let-7a-3p | DR1 | 0.17 | 0.43183 | -0.02 | 0.85269 | MirTarget | -0.13 | 1.0E-5 | NA | |
| 61 | hsa-let-7a-3p | E2F8 | 0.17 | 0.43183 | 3.42 | 0 | MirTarget | -0.19 | 0.01388 | NA | |
| 62 | hsa-let-7a-3p | EIF2AK2 | 0.17 | 0.43183 | 0.62 | 9.0E-5 | MirTarget | -0.11 | 0.00438 | NA | |
| 63 | hsa-let-7a-3p | ELOVL2 | 0.17 | 0.43183 | 0.7 | 0.05587 | miRNATAP | -0.21 | 0.01727 | NA | |
| 64 | hsa-let-7a-3p | ELOVL6 | 0.17 | 0.43183 | 0.82 | 0.02787 | mirMAP | -0.26 | 0.00415 | NA | |
| 65 | hsa-let-7a-3p | ELOVL7 | 0.17 | 0.43183 | -0.31 | 0.30162 | miRNATAP | -0.17 | 0.01825 | NA | |
| 66 | hsa-let-7a-3p | ENPP4 | 0.17 | 0.43183 | -0.72 | 0.00013 | mirMAP | -0.1 | 0.02691 | NA | |
| 67 | hsa-let-7a-3p | ESRP1 | 0.17 | 0.43183 | 1.06 | 0 | MirTarget | -0.1 | 0.03244 | NA | |
| 68 | hsa-let-7a-3p | EVI2A | 0.17 | 0.43183 | -0.97 | 9.0E-5 | MirTarget | -0.15 | 0.01249 | NA | |
| 69 | hsa-let-7a-3p | EXO1 | 0.17 | 0.43183 | 3.42 | 0 | MirTarget | -0.24 | 0.00703 | NA | |
| 70 | hsa-let-7a-3p | FAM126A | 0.17 | 0.43183 | 0.13 | 0.58359 | MirTarget | -0.18 | 0.00181 | NA | |
| 71 | hsa-let-7a-3p | FAM199X | 0.17 | 0.43183 | 0.79 | 0 | MirTarget; miRNATAP | -0.1 | 0.00218 | NA | |
| 72 | hsa-let-7a-3p | FGF12 | 0.17 | 0.43183 | -0.54 | 0.24373 | MirTarget | -0.25 | 0.02605 | NA | |
| 73 | hsa-let-7a-3p | FOXN2 | 0.17 | 0.43183 | -0.36 | 0.00692 | MirTarget; miRNATAP | -0.15 | 0 | NA | |
| 74 | hsa-let-7a-3p | FRMD3 | 0.17 | 0.43183 | -3.32 | 0 | mirMAP; miRNATAP | -0.22 | 0.00785 | NA | |
| 75 | hsa-let-7a-3p | FUT4 | 0.17 | 0.43183 | 0.11 | 0.54891 | mirMAP | -0.12 | 0.0065 | NA | |
| 76 | hsa-let-7a-3p | FZD5 | 0.17 | 0.43183 | -0.71 | 0.00011 | miRNATAP | -0.12 | 0.00992 | NA | |
| 77 | hsa-let-7a-3p | GDF11 | 0.17 | 0.43183 | 0.03 | 0.87092 | mirMAP | -0.11 | 0.0137 | NA | |
| 78 | hsa-let-7a-3p | GDPD1 | 0.17 | 0.43183 | 0.78 | 0.00033 | MirTarget | -0.17 | 0.00192 | NA | |
| 79 | hsa-let-7a-3p | GLDC | 0.17 | 0.43183 | 1.59 | 0.0024 | MirTarget | -0.32 | 0.01281 | NA | |
| 80 | hsa-let-7a-3p | GLS | 0.17 | 0.43183 | -0.28 | 0.29676 | miRNATAP | -0.17 | 0.0081 | NA | |
| 81 | hsa-let-7a-3p | GNA13 | 0.17 | 0.43183 | -0.13 | 0.24913 | MirTarget | -0.12 | 1.0E-5 | NA | |
| 82 | hsa-let-7a-3p | GPRIN3 | 0.17 | 0.43183 | -1.1 | 3.0E-5 | MirTarget; mirMAP | -0.22 | 0.0007 | NA | |
| 83 | hsa-let-7a-3p | GSTCD | 0.17 | 0.43183 | 0.42 | 0.00333 | mirMAP | -0.11 | 0.00189 | NA | |
| 84 | hsa-let-7a-3p | GTF2A1 | 0.17 | 0.43183 | -0.14 | 0.4882 | MirTarget; miRNATAP | -0.14 | 0.00426 | NA | |
| 85 | hsa-let-7a-3p | GXYLT1 | 0.17 | 0.43183 | -0.11 | 0.37942 | mirMAP | -0.11 | 0.00065 | NA | |
| 86 | hsa-let-7a-3p | HCFC2 | 0.17 | 0.43183 | -0.62 | 0 | miRNATAP | -0.12 | 0.00011 | NA | |
| 87 | hsa-let-7a-3p | HFE | 0.17 | 0.43183 | -0.05 | 0.81838 | mirMAP | -0.13 | 0.01075 | NA | |
| 88 | hsa-let-7a-3p | HGF | 0.17 | 0.43183 | -1.47 | 2.0E-5 | mirMAP | -0.22 | 0.00866 | NA | |
| 89 | hsa-let-7a-3p | HOXC8 | 0.17 | 0.43183 | 1 | 0.08388 | miRNATAP | -0.31 | 0.02966 | NA | |
| 90 | hsa-let-7a-5p | HRAS | -1.37 | 0 | 0.14 | 0.35812 | miRNAWalker2 validate; miRTarBase | -0.14 | 0.00016 | 18344688; 20033209; 20607356; 23134218; 19323605 | Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA |
| 91 | hsa-miR-143-3p | HRAS | -1.21 | 1.0E-5 | 0.14 | 0.35812 | miRNAWalker2 validate; miRTarBase | -0.13 | 0 | 21276449 | The Evi1 microRNA 143 K Ras axis in colon cancer |
| 92 | hsa-let-7a-3p | ID2 | 0.17 | 0.43183 | -1.25 | 0 | miRNATAP | -0.14 | 0.01058 | NA | |
| 93 | hsa-let-7a-3p | IGFBP1 | 0.17 | 0.43183 | 0.07 | 0.91515 | MirTarget | -0.34 | 0.0324 | NA | |
| 94 | hsa-let-7a-3p | IL6ST | 0.17 | 0.43183 | -1.4 | 0 | mirMAP | -0.18 | 0.01237 | NA | |
| 95 | hsa-let-7a-3p | IMPAD1 | 0.17 | 0.43183 | 0.09 | 0.48168 | MirTarget | -0.13 | 7.0E-5 | NA | |
| 96 | hsa-let-7a-3p | IPMK | 0.17 | 0.43183 | -0.02 | 0.93735 | mirMAP | -0.26 | 2.0E-5 | NA | |
| 97 | hsa-let-7a-3p | ITM2C | 0.17 | 0.43183 | 0.98 | 0 | MirTarget | -0.18 | 0.00015 | NA | |
| 98 | hsa-miR-940 | JMJD7-PLA2G4B | 0.01 | 0.97493 | -0.4 | 0.03394 | miRNATAP | -0.12 | 2.0E-5 | NA | |
| 99 | hsa-let-7a-3p | KBTBD8 | 0.17 | 0.43183 | -0.82 | 0.00029 | mirMAP | -0.14 | 0.01084 | NA | |
| 100 | hsa-miR-15a-5p | KDR | 1.63 | 0 | -1.29 | 1.0E-5 | miRNATAP | -0.28 | 8.0E-5 | NA | |
| 101 | hsa-miR-16-5p | KDR | 0.75 | 0 | -1.29 | 1.0E-5 | miRTarBase; miRNATAP | -0.3 | 0.00018 | 26934556 | The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 |
| 102 | hsa-miR-19b-1-5p | KDR | 1.71 | 0 | -1.29 | 1.0E-5 | miRNAWalker2 validate | -0.22 | 0.00036 | NA | |
| 103 | hsa-miR-200c-3p | KDR | 0.38 | 0.08422 | -1.29 | 1.0E-5 | miRNATAP | -0.27 | 1.0E-5 | 24205206 | MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c |
| 104 | hsa-miR-429 | KDR | 2.38 | 0 | -1.29 | 1.0E-5 | PITA; miRanda; miRNATAP | -0.11 | 0.00976 | NA | |
| 105 | hsa-miR-590-3p | KDR | 0.84 | 0.00129 | -1.29 | 1.0E-5 | miRanda | -0.24 | 6.0E-5 | NA | |
| 106 | hsa-miR-590-5p | KDR | 2.07 | 0 | -1.29 | 1.0E-5 | miRanda | -0.25 | 2.0E-5 | NA | |
| 107 | hsa-let-7a-3p | KRAS | 0.17 | 0.43183 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.17 | 5.0E-5 | 24727325; 20603437; 24890702; 23324806; 21994416; 23167843; 27620744; 20177422; 25183481; 22584434; 18922928 | Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility |
| 108 | hsa-let-7b-3p | KRAS | -1.82 | 0 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.21 | 0 | 24727325; 20603437; 24890702; 23324806; 21994416; 23167843; 27620744; 20177422; 25183481; 26581910; 22584434; 26516699; 18922928 | Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility |
| 109 | hsa-miR-1-3p | KRAS | -1.48 | 0.00024 | 0.54 | 0.00142 | MirTarget | -0.11 | 0 | NA | |
| 110 | hsa-miR-126-3p | KRAS | 0.4 | 0.11564 | 0.54 | 0.00142 | miRNAWalker2 validate; miRTarBase | -0.14 | 0 | 22845403 | miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK |
| 111 | hsa-miR-1271-5p | KRAS | -0.02 | 0.9511 | 0.54 | 0.00142 | MirTarget | -0.11 | 7.0E-5 | NA | |
| 112 | hsa-miR-140-3p | KRAS | -1.11 | 0 | 0.54 | 0.00142 | MirTarget | -0.38 | 0 | NA | |
| 113 | hsa-miR-155-5p | KRAS | 0.81 | 0.00061 | 0.54 | 0.00142 | miRNAWalker2 validate; miRNATAP | -0.14 | 3.0E-5 | NA | |
| 114 | hsa-miR-16-1-3p | KRAS | 1.5 | 0 | 0.54 | 0.00142 | mirMAP | -0.12 | 0.00206 | NA | |
| 115 | hsa-miR-181a-5p | KRAS | -0.38 | 0.05621 | 0.54 | 0.00142 | miRNAWalker2 validate | -0.23 | 0 | 24098024; 27517749; 26124189 | The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients |
| 116 | hsa-miR-181c-5p | KRAS | 0.53 | 0.01259 | 0.54 | 0.00142 | miRNAWalker2 validate; miRTarBase | -0.11 | 0.002 | NA | |
| 117 | hsa-miR-186-5p | KRAS | 0.85 | 0 | 0.54 | 0.00142 | mirMAP | -0.17 | 0.00201 | NA | |
| 118 | hsa-miR-193a-3p | KRAS | 0.55 | 0.0319 | 0.54 | 0.00142 | MirTarget; miRanda; miRNATAP | -0.11 | 0.00055 | NA | |
| 119 | hsa-miR-193a-5p | KRAS | -1.16 | 0 | 0.54 | 0.00142 | miRNATAP | -0.14 | 0.00022 | NA | |
| 120 | hsa-miR-195-3p | KRAS | -1.33 | 0 | 0.54 | 0.00142 | mirMAP | -0.26 | 0 | NA | |
| 121 | hsa-miR-199a-5p | KRAS | 1.31 | 0 | 0.54 | 0.00142 | miRanda; miRNATAP | -0.19 | 0 | NA | |
| 122 | hsa-miR-199b-5p | KRAS | 2.14 | 0 | 0.54 | 0.00142 | miRanda; miRNATAP | -0.16 | 0 | 27517624 | The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups |
| 123 | hsa-miR-224-3p | KRAS | 0.92 | 0.01001 | 0.54 | 0.00142 | mirMAP | -0.12 | 0 | 25919696 | MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins |
| 124 | hsa-miR-27b-3p | KRAS | 0.24 | 0.12264 | 0.54 | 0.00142 | miRNATAP | -0.14 | 0.00626 | NA | |
| 125 | hsa-miR-30a-3p | KRAS | -2.54 | 0 | 0.54 | 0.00142 | MirTarget; miRNATAP | -0.12 | 0 | NA | |
| 126 | hsa-miR-30a-5p | KRAS | -0.92 | 0.00076 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.16 | 0 | NA | |
| 127 | hsa-miR-30b-5p | KRAS | 0.36 | 0.13803 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.15 | 0 | NA | |
| 128 | hsa-miR-30c-5p | KRAS | -0.33 | 0.1236 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.3 | 0 | 22701724 | Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling |
| 129 | hsa-miR-30d-3p | KRAS | 0 | 0.98646 | 0.54 | 0.00142 | MirTarget; miRNATAP | -0.12 | 0.00128 | NA | |
| 130 | hsa-miR-30d-5p | KRAS | -0.92 | 4.0E-5 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.12 | 0.00036 | NA | |
| 131 | hsa-miR-30e-3p | KRAS | -0.1 | 0.52624 | 0.54 | 0.00142 | MirTarget | -0.25 | 0 | NA | |
| 132 | hsa-miR-30e-5p | KRAS | 1.6 | 0 | 0.54 | 0.00142 | mirMAP; miRNATAP | -0.13 | 0.00268 | NA | |
| 133 | hsa-miR-501-3p | KRAS | -0.04 | 0.8668 | 0.54 | 0.00142 | MirTarget; PITA; TargetScan; miRNATAP | -0.12 | 0.00011 | NA | |
| 134 | hsa-miR-502-3p | KRAS | -0.26 | 0.16176 | 0.54 | 0.00142 | MirTarget; PITA; miRNATAP | -0.12 | 0.00538 | NA | |
| 135 | hsa-miR-532-5p | KRAS | 0.58 | 0.00232 | 0.54 | 0.00142 | MirTarget; PITA; miRNATAP | -0.12 | 0.00273 | NA | |
| 136 | hsa-let-7a-3p | LARP4 | 0.17 | 0.43183 | 0.16 | 0.18031 | mirMAP | -0.11 | 0.00024 | NA | |
| 137 | hsa-let-7a-3p | LCOR | 0.17 | 0.43183 | 0.64 | 0.00374 | mirMAP; miRNATAP | -0.14 | 0.01197 | NA | |
| 138 | hsa-let-7a-3p | LEPROTL1 | 0.17 | 0.43183 | -0.34 | 0.00372 | mirMAP | -0.1 | 0.0004 | NA | |
| 139 | hsa-let-7a-3p | LIMS1 | 0.17 | 0.43183 | -0.7 | 0.00015 | mirMAP | -0.15 | 0.00066 | NA | |
| 140 | hsa-let-7a-3p | LIN7A | 0.17 | 0.43183 | -3.21 | 0 | mirMAP | -0.18 | 0.04728 | NA | |
| 141 | hsa-let-7a-3p | LIN9 | 0.17 | 0.43183 | 0.6 | 0.00021 | MirTarget; miRNATAP | -0.11 | 0.00694 | NA | |
| 142 | hsa-let-7a-3p | LRRC40 | 0.17 | 0.43183 | 0.14 | 0.26738 | mirMAP | -0.11 | 0.0003 | NA | |
| 143 | hsa-let-7a-3p | MAN1A1 | 0.17 | 0.43183 | -1.14 | 0 | MirTarget | -0.21 | 0.00038 | NA | |
| 144 | hsa-miR-30c-5p | MAP2K1 | -0.33 | 0.1236 | -0.13 | 0.25581 | miRNAWalker2 validate | -0.15 | 0 | NA | |
| 145 | hsa-miR-497-5p | MAP2K1 | -0.05 | 0.78621 | -0.13 | 0.25581 | miRNAWalker2 validate | -0.15 | 0 | NA | |
| 146 | hsa-let-7a-3p | MAP4K3 | 0.17 | 0.43183 | 0.22 | 0.05375 | mirMAP | -0.13 | 0 | NA | |
| 147 | hsa-miR-130a-3p | MAPK1 | 0.88 | 0.00016 | -0.31 | 0.00657 | mirMAP | -0.1 | 1.0E-5 | NA | |
| 148 | hsa-miR-140-5p | MAPK1 | 0.67 | 0.00034 | -0.31 | 0.00657 | miRanda | -0.11 | 0.0003 | NA | |
| 149 | hsa-miR-148a-3p | MAPK1 | 2.31 | 0 | -0.31 | 0.00657 | mirMAP | -0.1 | 0 | NA | |
| 150 | hsa-miR-24-1-5p | MAPK1 | 0.86 | 0.00011 | -0.31 | 0.00657 | mirMAP | -0.11 | 1.0E-5 | NA |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 62 | 1929 | 2.055e-16 | 9.56e-13 |
| 2 | PHOSPHATIDYLETHANOLAMINE ACYL CHAIN REMODELING | 10 | 23 | 1.211e-14 | 2.818e-11 |
| 3 | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 14 | 74 | 2.937e-14 | 4.556e-11 |
| 4 | PHOSPHATIDYLCHOLINE ACYL CHAIN REMODELING | 10 | 26 | 5.474e-14 | 6.367e-11 |
| 5 | INTRACELLULAR SIGNAL TRANSDUCTION | 51 | 1572 | 1.43e-13 | 1.331e-10 |
| 6 | POSITIVE REGULATION OF CELL COMMUNICATION | 50 | 1532 | 2.108e-13 | 1.635e-10 |
| 7 | IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY | 23 | 323 | 4.293e-13 | 2.854e-10 |
| 8 | FC RECEPTOR SIGNALING PATHWAY | 19 | 206 | 5.384e-13 | 3.131e-10 |
| 9 | PHOSPHATIDYLINOSITOL ACYL CHAIN REMODELING | 8 | 16 | 1.433e-12 | 7.409e-10 |
| 10 | PHOSPHATIDYLINOSITOL METABOLIC PROCESS | 18 | 193 | 1.865e-12 | 7.738e-10 |
| 11 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 39 | 1036 | 2.162e-12 | 7.738e-10 |
| 12 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 39 | 1036 | 2.162e-12 | 7.738e-10 |
| 13 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 56 | 1977 | 1.802e-12 | 7.738e-10 |
| 14 | PHOSPHATIDYLSERINE ACYL CHAIN REMODELING | 8 | 17 | 2.683e-12 | 8.322e-10 |
| 15 | PHOSPHATIDYLGLYCEROL ACYL CHAIN REMODELING | 8 | 17 | 2.683e-12 | 8.322e-10 |
| 16 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 50 | 1656 | 3.885e-12 | 1.13e-09 |
| 17 | POSITIVE REGULATION OF GENE EXPRESSION | 51 | 1733 | 5.811e-12 | 1.591e-09 |
| 18 | POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 35 | 876 | 6.631e-12 | 1.714e-09 |
| 19 | POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 40 | 1135 | 8.417e-12 | 2.061e-09 |
| 20 | TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY | 26 | 498 | 1.426e-11 | 3.318e-09 |
| 21 | PHOSPHATIDYLGLYCEROL METABOLIC PROCESS | 9 | 31 | 1.979e-11 | 4.385e-09 |
| 22 | FC EPSILON RECEPTOR SIGNALING PATHWAY | 15 | 142 | 2.325e-11 | 4.918e-09 |
| 23 | GLYCEROPHOSPHOLIPID METABOLIC PROCESS | 20 | 297 | 4.298e-11 | 8.694e-09 |
| 24 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 50 | 1805 | 8.745e-11 | 1.695e-08 |
| 25 | ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY | 29 | 689 | 1.55e-10 | 2.885e-08 |
| 26 | POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS | 44 | 1492 | 2.194e-10 | 3.926e-08 |
| 27 | PHOSPHOLIPID METABOLIC PROCESS | 21 | 364 | 2.426e-10 | 4.181e-08 |
| 28 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 46 | 1618 | 2.589e-10 | 4.302e-08 |
| 29 | PHOSPHATIDYLSERINE METABOLIC PROCESS | 8 | 28 | 3.109e-10 | 4.989e-08 |
| 30 | PHOSPHORYLATION | 39 | 1228 | 3.466e-10 | 5.376e-08 |
| 31 | REGULATION OF PROTEIN MODIFICATION PROCESS | 47 | 1710 | 4.842e-10 | 7.268e-08 |
| 32 | REGULATION OF KINASE ACTIVITY | 30 | 776 | 5.551e-10 | 8.071e-08 |
| 33 | GLYCEROLIPID METABOLIC PROCESS | 20 | 356 | 1.054e-09 | 1.486e-07 |
| 34 | PHOSPHATIDYLCHOLINE METABOLIC PROCESS | 10 | 64 | 1.107e-09 | 1.515e-07 |
| 35 | ETHANOLAMINE CONTAINING COMPOUND METABOLIC PROCESS | 11 | 85 | 1.286e-09 | 1.71e-07 |
| 36 | POSITIVE REGULATION OF KINASE ACTIVITY | 23 | 482 | 1.335e-09 | 1.725e-07 |
| 37 | REGULATION OF IMMUNE RESPONSE | 31 | 858 | 1.423e-09 | 1.789e-07 |
| 38 | REGULATION OF CELL JUNCTION ASSEMBLY | 10 | 68 | 2.05e-09 | 2.51e-07 |
| 39 | ALDITOL PHOSPHATE METABOLIC PROCESS | 8 | 35 | 2.212e-09 | 2.554e-07 |
| 40 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 47 | 1791 | 2.191e-09 | 2.554e-07 |
| 41 | LIPID BIOSYNTHETIC PROCESS | 24 | 539 | 2.25e-09 | 2.554e-07 |
| 42 | PLATELET ACTIVATION | 13 | 142 | 3.067e-09 | 3.398e-07 |
| 43 | POSITIVE REGULATION OF LOCOMOTION | 21 | 420 | 3.193e-09 | 3.455e-07 |
| 44 | PHOSPHOLIPID BIOSYNTHETIC PROCESS | 16 | 235 | 3.488e-09 | 3.689e-07 |
| 45 | REGULATION OF TRANSFERASE ACTIVITY | 32 | 946 | 3.733e-09 | 3.86e-07 |
| 46 | POSITIVE REGULATION OF MAPK CASCADE | 22 | 470 | 4.434e-09 | 4.461e-07 |
| 47 | REGULATION OF IMMUNE SYSTEM PROCESS | 40 | 1403 | 4.506e-09 | 4.461e-07 |
| 48 | HEMOSTASIS | 18 | 311 | 4.698e-09 | 4.554e-07 |
| 49 | EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 9 | 55 | 5.031e-09 | 4.777e-07 |
| 50 | GLYCEROLIPID BIOSYNTHETIC PROCESS | 15 | 211 | 6.095e-09 | 5.672e-07 |
| 51 | POSITIVE REGULATION OF TRANSFERASE ACTIVITY | 25 | 616 | 6.621e-09 | 6.041e-07 |
| 52 | ERBB SIGNALING PATHWAY | 10 | 79 | 9.198e-09 | 8.231e-07 |
| 53 | POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 35 | 1152 | 1.004e-08 | 8.814e-07 |
| 54 | ANGIOGENESIS | 17 | 293 | 1.235e-08 | 1.064e-06 |
| 55 | INOSITOL PHOSPHATE MEDIATED SIGNALING | 6 | 18 | 1.969e-08 | 1.666e-06 |
| 56 | VASCULATURE DEVELOPMENT | 21 | 469 | 2.193e-08 | 1.822e-06 |
| 57 | SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION | 18 | 352 | 3.189e-08 | 2.604e-06 |
| 58 | REGULATION OF CELL SUBSTRATE ADHESION | 13 | 173 | 3.344e-08 | 2.637e-06 |
| 59 | REGULATION OF CELL MATRIX ADHESION | 10 | 90 | 3.307e-08 | 2.637e-06 |
| 60 | POSITIVE REGULATION OF MAP KINASE ACTIVITY | 14 | 207 | 3.725e-08 | 2.889e-06 |
| 61 | POSITIVE REGULATION OF CATALYTIC ACTIVITY | 40 | 1518 | 4.011e-08 | 3.032e-06 |
| 62 | PHOSPHATIDIC ACID METABOLIC PROCESS | 7 | 33 | 4.04e-08 | 3.032e-06 |
| 63 | REGULATION OF MAP KINASE ACTIVITY | 17 | 319 | 4.3e-08 | 3.176e-06 |
| 64 | REGULATION OF ADHERENS JUNCTION ORGANIZATION | 8 | 50 | 4.414e-08 | 3.209e-06 |
| 65 | PROTEIN PHOSPHORYLATION | 30 | 944 | 4.9e-08 | 3.507e-06 |
| 66 | CELLULAR LIPID METABOLIC PROCESS | 29 | 913 | 8.5e-08 | 5.992e-06 |
| 67 | POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS | 28 | 867 | 1.034e-07 | 7.179e-06 |
| 68 | REGULATION OF MAPK CASCADE | 24 | 660 | 1.072e-07 | 7.334e-06 |
| 69 | REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 20 | 470 | 1.107e-07 | 7.356e-06 |
| 70 | POSITIVE REGULATION OF IMMUNE RESPONSE | 22 | 563 | 1.101e-07 | 7.356e-06 |
| 71 | ACTIVATION OF IMMUNE RESPONSE | 19 | 427 | 1.173e-07 | 7.685e-06 |
| 72 | CELL ACTIVATION | 22 | 568 | 1.283e-07 | 8.069e-06 |
| 73 | AMINE METABOLIC PROCESS | 11 | 131 | 1.261e-07 | 8.069e-06 |
| 74 | LIPID METABOLIC PROCESS | 33 | 1158 | 1.269e-07 | 8.069e-06 |
| 75 | REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 43 | 1784 | 1.42e-07 | 8.812e-06 |
| 76 | ALCOHOL METABOLIC PROCESS | 17 | 348 | 1.503e-07 | 9.205e-06 |
| 77 | PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 6 | 25 | 1.768e-07 | 1.068e-05 |
| 78 | REGULATION OF CELL ADHESION | 23 | 629 | 1.824e-07 | 1.088e-05 |
| 79 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 30 | 1004 | 1.869e-07 | 1.101e-05 |
| 80 | CARDIOVASCULAR SYSTEM DEVELOPMENT | 26 | 788 | 2.043e-07 | 1.174e-05 |
| 81 | CIRCULATORY SYSTEM DEVELOPMENT | 26 | 788 | 2.043e-07 | 1.174e-05 |
| 82 | AMMONIUM ION METABOLIC PROCESS | 12 | 169 | 2.122e-07 | 1.204e-05 |
| 83 | ACTIVATION OF PROTEIN KINASE ACTIVITY | 15 | 279 | 2.459e-07 | 1.378e-05 |
| 84 | BLOOD VESSEL MORPHOGENESIS | 17 | 364 | 2.84e-07 | 1.573e-05 |
| 85 | LIPID CATABOLIC PROCESS | 14 | 247 | 3.307e-07 | 1.81e-05 |
| 86 | POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 15 | 289 | 3.858e-07 | 2.088e-05 |
| 87 | CALCIUM MEDIATED SIGNALING | 9 | 90 | 4.082e-07 | 2.183e-05 |
| 88 | POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION | 20 | 514 | 4.602e-07 | 2.433e-05 |
| 89 | REGULATION OF CELLULAR COMPONENT MOVEMENT | 25 | 771 | 4.933e-07 | 2.579e-05 |
| 90 | WOUND HEALING | 19 | 470 | 5.096e-07 | 2.635e-05 |
| 91 | REGULATION OF INTRACELLULAR TRANSPORT | 22 | 621 | 5.849e-07 | 2.991e-05 |
| 92 | FC GAMMA RECEPTOR SIGNALING PATHWAY | 9 | 95 | 6.494e-07 | 3.284e-05 |
| 93 | REGULATION OF CELL PROLIFERATION | 37 | 1496 | 6.774e-07 | 3.389e-05 |
| 94 | REGULATION OF CYTOPLASMIC TRANSPORT | 19 | 481 | 7.217e-07 | 3.573e-05 |
| 95 | LIPID PHOSPHORYLATION | 9 | 99 | 9.23e-07 | 4.521e-05 |
| 96 | CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND | 25 | 799 | 9.469e-07 | 4.59e-05 |
| 97 | CELLULAR RESPONSE TO PEPTIDE | 14 | 274 | 1.148e-06 | 5.505e-05 |
| 98 | ORGANOPHOSPHATE BIOSYNTHETIC PROCESS | 18 | 450 | 1.198e-06 | 5.689e-05 |
| 99 | POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION | 16 | 360 | 1.235e-06 | 5.805e-05 |
| 100 | REGULATION OF TRANSPORT | 41 | 1804 | 1.366e-06 | 6.356e-05 |
| 101 | REGULATION OF BODY FLUID LEVELS | 19 | 506 | 1.533e-06 | 7.06e-05 |
| 102 | REGULATION OF CELLULAR COMPONENT BIOGENESIS | 24 | 767 | 1.588e-06 | 7.234e-05 |
| 103 | POSITIVE REGULATION OF TRANSPORT | 27 | 936 | 1.601e-06 | 7.234e-05 |
| 104 | LOCOMOTION | 30 | 1114 | 1.642e-06 | 7.348e-05 |
| 105 | TAXIS | 18 | 464 | 1.85e-06 | 8.198e-05 |
| 106 | RESPONSE TO WOUNDING | 20 | 563 | 1.881e-06 | 8.257e-05 |
| 107 | CELL CYCLE | 33 | 1316 | 2.222e-06 | 9.663e-05 |
| 108 | ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS | 27 | 957 | 2.431e-06 | 0.0001047 |
| 109 | POSITIVE REGULATION OF ORGANELLE ORGANIZATION | 20 | 573 | 2.457e-06 | 0.0001049 |
| 110 | TISSUE DEVELOPMENT | 36 | 1518 | 2.605e-06 | 0.0001102 |
| 111 | REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS | 28 | 1021 | 2.683e-06 | 0.0001125 |
| 112 | POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS | 14 | 296 | 2.841e-06 | 0.000118 |
| 113 | ERBB2 SIGNALING PATHWAY | 6 | 39 | 2.885e-06 | 0.0001188 |
| 114 | ORGANIC HYDROXY COMPOUND METABOLIC PROCESS | 18 | 482 | 3.155e-06 | 0.0001285 |
| 115 | MOVEMENT OF CELL OR SUBCELLULAR COMPONENT | 32 | 1275 | 3.177e-06 | 0.0001285 |
| 116 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 6 | 40 | 3.365e-06 | 0.0001338 |
| 117 | POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS | 5 | 23 | 3.35e-06 | 0.0001338 |
| 118 | LEUKOCYTE MIGRATION | 13 | 259 | 3.396e-06 | 0.0001339 |
| 119 | PEPTIDYL SERINE MODIFICATION | 10 | 148 | 3.491e-06 | 0.0001365 |
| 120 | IMMUNE EFFECTOR PROCESS | 18 | 486 | 3.539e-06 | 0.0001372 |
| 121 | POSITIVE REGULATION OF LAMELLIPODIUM ORGANIZATION | 5 | 24 | 4.196e-06 | 0.0001613 |
| 122 | REGULATION OF SUBSTRATE ADHESION DEPENDENT CELL SPREADING | 6 | 43 | 5.207e-06 | 0.000197 |
| 123 | CELLULAR RESPONSE TO STRESS | 36 | 1565 | 5.194e-06 | 0.000197 |
| 124 | POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS | 4 | 12 | 5.27e-06 | 0.0001978 |
| 125 | REGULATION OF CELLULAR PROTEIN LOCALIZATION | 19 | 552 | 5.419e-06 | 0.0002017 |
| 126 | IMMUNE SYSTEM PROCESS | 42 | 1984 | 6.034e-06 | 0.0002228 |
| 127 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 40 | 1848 | 6.22e-06 | 0.0002261 |
| 128 | RESPONSE TO OXYGEN CONTAINING COMPOUND | 33 | 1381 | 6.202e-06 | 0.0002261 |
| 129 | REGULATION OF CELL PROJECTION ORGANIZATION | 19 | 558 | 6.322e-06 | 0.000227 |
| 130 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 27 | 1008 | 6.343e-06 | 0.000227 |
| 131 | RESPONSE TO ENDOGENOUS STIMULUS | 34 | 1450 | 6.594e-06 | 0.0002342 |
| 132 | CELL MOTILITY | 24 | 835 | 6.777e-06 | 0.0002371 |
| 133 | LOCALIZATION OF CELL | 24 | 835 | 6.777e-06 | 0.0002371 |
| 134 | POSITIVE REGULATION OF INTRACELLULAR TRANSPORT | 15 | 370 | 8.151e-06 | 0.000283 |
| 135 | REGULATION OF LIPID METABOLIC PROCESS | 13 | 282 | 8.542e-06 | 0.0002944 |
| 136 | SINGLE ORGANISM BIOSYNTHETIC PROCESS | 32 | 1340 | 8.857e-06 | 0.000303 |
| 137 | REGULATION OF CELL DEATH | 34 | 1472 | 9.082e-06 | 0.0003085 |
| 138 | REGULATION OF EPITHELIAL CELL MIGRATION | 10 | 166 | 9.684e-06 | 0.0003265 |
| 139 | REGULATION OF LIPID KINASE ACTIVITY | 6 | 48 | 1.004e-05 | 0.000336 |
| 140 | RESPONSE TO NITROGEN COMPOUND | 24 | 859 | 1.086e-05 | 0.0003609 |
| 141 | PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS | 6 | 49 | 1.134e-05 | 0.0003742 |
| 142 | POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION | 8 | 103 | 1.221e-05 | 4e-04 |
| 143 | VESICLE MEDIATED TRANSPORT | 30 | 1239 | 1.345e-05 | 0.0004375 |
| 144 | REGULATION OF ORGANELLE ORGANIZATION | 29 | 1178 | 1.398e-05 | 0.0004517 |
| 145 | POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS | 6 | 51 | 1.435e-05 | 0.0004594 |
| 146 | PLACENTA DEVELOPMENT | 9 | 138 | 1.442e-05 | 0.0004594 |
| 147 | POSITIVE REGULATION OF HOMEOSTATIC PROCESS | 11 | 216 | 1.703e-05 | 0.000539 |
| 148 | POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT | 12 | 258 | 1.746e-05 | 0.0005489 |
| 149 | POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION | 13 | 303 | 1.832e-05 | 0.000572 |
| 150 | REGULATION OF MITOCHONDRION ORGANIZATION | 11 | 218 | 1.855e-05 | 0.0005725 |
| 151 | PATTERNING OF BLOOD VESSELS | 5 | 32 | 1.858e-05 | 0.0005725 |
| 152 | REGULATION OF PROTEIN LOCALIZATION | 25 | 950 | 1.936e-05 | 0.0005928 |
| 153 | CELLULAR RESPONSE TO HORMONE STIMULUS | 18 | 552 | 1.994e-05 | 0.0006025 |
| 154 | REGULATION OF CELL MORPHOGENESIS | 18 | 552 | 1.994e-05 | 0.0006025 |
| 155 | POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING | 7 | 81 | 2.156e-05 | 0.0006473 |
| 156 | REGULATION OF RESPONSE TO STRESS | 33 | 1468 | 2.177e-05 | 0.0006485 |
| 157 | SINGLE ORGANISM CATABOLIC PROCESS | 25 | 957 | 2.188e-05 | 0.0006485 |
| 158 | CELLULAR RESPONSE TO NITROGEN COMPOUND | 17 | 505 | 2.286e-05 | 0.0006731 |
| 159 | REGULATION OF CELLULAR LOCALIZATION | 30 | 1277 | 2.385e-05 | 0.0006981 |
| 160 | REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS | 4 | 17 | 2.433e-05 | 0.0007074 |
| 161 | POSITIVE REGULATION OF DNA METABOLIC PROCESS | 10 | 185 | 2.484e-05 | 0.0007178 |
| 162 | FATTY ACID BIOSYNTHETIC PROCESS | 8 | 114 | 2.563e-05 | 0.0007361 |
| 163 | ENDOTHELIAL CELL MIGRATION | 6 | 57 | 2.746e-05 | 0.000784 |
| 164 | MULTICELLULAR ORGANISMAL HOMEOSTASIS | 12 | 272 | 2.939e-05 | 0.0008339 |
| 165 | REGULATION OF CELL DIFFERENTIATION | 33 | 1492 | 3.012e-05 | 0.0008484 |
| 166 | REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 14 | 365 | 3.027e-05 | 0.0008484 |
| 167 | ENDOMEMBRANE SYSTEM ORGANIZATION | 16 | 465 | 3.078e-05 | 0.0008575 |
| 168 | PHAGOCYTOSIS | 10 | 190 | 3.121e-05 | 0.0008644 |
| 169 | REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS | 6 | 59 | 3.352e-05 | 0.0009228 |
| 170 | REGULATION OF LAMELLIPODIUM ORGANIZATION | 5 | 37 | 3.855e-05 | 0.001055 |
| 171 | RESPONSE TO GROWTH FACTOR | 16 | 475 | 3.971e-05 | 0.001081 |
| 172 | REGULATION OF PHOSPHOLIPID METABOLIC PROCESS | 6 | 61 | 4.06e-05 | 0.001098 |
| 173 | POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT | 12 | 282 | 4.178e-05 | 0.001124 |
| 174 | SECOND MESSENGER MEDIATED SIGNALING | 9 | 160 | 4.655e-05 | 0.001245 |
| 175 | CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS | 4 | 20 | 4.832e-05 | 0.001278 |
| 176 | REGULATION OF INTRACELLULAR PROTEIN TRANSPORT | 14 | 381 | 4.823e-05 | 0.001278 |
| 177 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 31 | 1395 | 4.957e-05 | 0.001303 |
| 178 | WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY | 5 | 39 | 5.007e-05 | 0.001309 |
| 179 | ORGANOPHOSPHATE METABOLIC PROCESS | 23 | 885 | 5.16e-05 | 0.001341 |
| 180 | POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION | 4 | 21 | 5.921e-05 | 0.00153 |
| 181 | CELL CYCLE PROCESS | 26 | 1081 | 5.969e-05 | 0.001535 |
| 182 | REGULATION OF CELL DEVELOPMENT | 22 | 836 | 6.311e-05 | 0.001613 |
| 183 | POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION | 9 | 167 | 6.492e-05 | 0.001624 |
| 184 | ICOSANOID METABOLIC PROCESS | 7 | 96 | 6.481e-05 | 0.001624 |
| 185 | MORPHOGENESIS OF A BRANCHING STRUCTURE | 9 | 167 | 6.492e-05 | 0.001624 |
| 186 | FATTY ACID DERIVATIVE METABOLIC PROCESS | 7 | 96 | 6.481e-05 | 0.001624 |
| 187 | PEPTIDYL AMINO ACID MODIFICATION | 22 | 841 | 6.887e-05 | 0.001714 |
| 188 | POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION | 6 | 67 | 6.928e-05 | 0.001715 |
| 189 | LIPID MODIFICATION | 10 | 210 | 7.263e-05 | 0.001788 |
| 190 | POSITIVE REGULATION OF VASCULATURE DEVELOPMENT | 8 | 133 | 7.712e-05 | 0.001889 |
| 191 | MONOCARBOXYLIC ACID METABOLIC PROCESS | 16 | 503 | 7.806e-05 | 0.001902 |
| 192 | MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS | 9 | 172 | 8.15e-05 | 0.001975 |
| 193 | RESPONSE TO PEPTIDE | 14 | 404 | 9.017e-05 | 0.002152 |
| 194 | SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION | 14 | 404 | 9.017e-05 | 0.002152 |
| 195 | ENDOCYTOSIS | 16 | 509 | 8.96e-05 | 0.002152 |
| 196 | REGULATION OF PROTEIN TARGETING | 12 | 307 | 9.418e-05 | 0.002236 |
| 197 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 8 | 138 | 9.991e-05 | 0.00236 |
| 198 | SPROUTING ANGIOGENESIS | 5 | 45 | 0.000101 | 0.002374 |
| 199 | REGULATION OF RESPONSE TO EXTERNAL STIMULUS | 23 | 926 | 0.0001019 | 0.002383 |
| 200 | POSITIVE REGULATION OF CELL JUNCTION ASSEMBLY | 4 | 24 | 0.0001026 | 0.002387 |
| 201 | REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT | 10 | 220 | 0.0001068 | 0.002472 |
| 202 | POSITIVE REGULATION OF PROTEIN IMPORT | 7 | 104 | 0.0001077 | 0.002481 |
| 203 | ICOSANOID BIOSYNTHETIC PROCESS | 5 | 46 | 0.0001124 | 0.002563 |
| 204 | FATTY ACID DERIVATIVE BIOSYNTHETIC PROCESS | 5 | 46 | 0.0001124 | 0.002563 |
| 205 | NEGATIVE REGULATION OF CELL DEATH | 22 | 872 | 0.0001163 | 0.002639 |
| 206 | CARBOXYLIC ACID BIOSYNTHETIC PROCESS | 11 | 270 | 0.0001284 | 0.002868 |
| 207 | ORGANIC ACID BIOSYNTHETIC PROCESS | 11 | 270 | 0.0001284 | 0.002868 |
| 208 | RESPONSE TO EXTERNAL STIMULUS | 36 | 1821 | 0.0001288 | 0.002868 |
| 209 | RAS PROTEIN SIGNAL TRANSDUCTION | 8 | 143 | 0.000128 | 0.002868 |
| 210 | HOMEOSTATIC PROCESS | 29 | 1337 | 0.0001355 | 0.003003 |
| 211 | EPITHELIUM DEVELOPMENT | 23 | 945 | 0.0001375 | 0.003033 |
| 212 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 26 | 1142 | 0.0001451 | 0.00317 |
| 213 | UNSATURATED FATTY ACID METABOLIC PROCESS | 7 | 109 | 0.0001446 | 0.00317 |
| 214 | CELLULAR RESPONSE TO INSULIN STIMULUS | 8 | 146 | 0.0001478 | 0.003214 |
| 215 | MITOTIC CELL CYCLE | 20 | 766 | 0.000153 | 0.003312 |
| 216 | RESPONSE TO INORGANIC SUBSTANCE | 15 | 479 | 0.0001553 | 0.003346 |
| 217 | RESPONSE TO HORMONE | 22 | 893 | 0.0001631 | 0.003496 |
| 218 | RESPONSE TO LITHIUM ION | 4 | 27 | 0.0001653 | 0.003529 |
| 219 | POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS | 3 | 11 | 0.000172 | 0.003655 |
| 220 | POSITIVE REGULATION OF SUBSTRATE ADHESION DEPENDENT CELL SPREADING | 4 | 28 | 0.0001913 | 0.00401 |
| 221 | POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE | 4 | 28 | 0.0001913 | 0.00401 |
| 222 | REGULATION OF ENDOTHELIAL CELL MIGRATION | 7 | 114 | 0.0001912 | 0.00401 |
| 223 | ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY | 9 | 195 | 0.0002108 | 0.004398 |
| 224 | REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 12 | 337 | 0.0002242 | 0.004658 |
| 225 | EMBRYONIC PLACENTA DEVELOPMENT | 6 | 83 | 0.0002283 | 0.004701 |
| 226 | FATTY ACID ELONGATION | 3 | 12 | 0.0002276 | 0.004701 |
| 227 | SMALL MOLECULE BIOSYNTHETIC PROCESS | 14 | 443 | 0.0002346 | 0.004794 |
| 228 | PROTEIN LOCALIZATION | 35 | 1805 | 0.0002349 | 0.004794 |
| 229 | TISSUE MIGRATION | 6 | 84 | 0.0002438 | 0.004954 |
| 230 | RESPONSE TO GROWTH HORMONE | 4 | 30 | 0.000252 | 0.005097 |
| 231 | REGULATION OF HOMEOSTATIC PROCESS | 14 | 447 | 0.0002571 | 0.005179 |
| 232 | PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS | 7 | 120 | 0.0002623 | 0.005193 |
| 233 | CYTOKINE PRODUCTION | 7 | 120 | 0.0002623 | 0.005193 |
| 234 | EPHRIN RECEPTOR SIGNALING PATHWAY | 6 | 85 | 0.0002601 | 0.005193 |
| 235 | POSITIVE REGULATION OF CHEMOTAXIS | 7 | 120 | 0.0002623 | 0.005193 |
| 236 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 33 | 1672 | 0.0002636 | 0.005197 |
| 237 | POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT | 7 | 121 | 0.000276 | 0.005395 |
| 238 | REGULATION OF PROTEIN KINASE B SIGNALING | 7 | 121 | 0.000276 | 0.005395 |
| 239 | POSITIVE REGULATION OF DNA REPLICATION | 6 | 86 | 0.0002772 | 0.005396 |
| 240 | REGULATION OF CYTOKINE PRODUCTION | 16 | 563 | 0.0002815 | 0.005458 |
| 241 | FATTY ACID METABOLIC PROCESS | 11 | 296 | 0.0002846 | 0.005494 |
| 242 | REGULATION OF DNA REPLICATION | 8 | 161 | 0.0002884 | 0.005546 |
| 243 | CELLULAR RESPONSE TO HEPATOCYTE GROWTH FACTOR STIMULUS | 3 | 13 | 0.0002936 | 0.005576 |
| 244 | RESPONSE TO HEPATOCYTE GROWTH FACTOR | 3 | 13 | 0.0002936 | 0.005576 |
| 245 | REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY | 3 | 13 | 0.0002936 | 0.005576 |
| 246 | CELL CHEMOTAXIS | 8 | 162 | 0.0003007 | 0.005635 |
| 247 | MORPHOGENESIS OF AN EPITHELIUM | 13 | 400 | 0.0002998 | 0.005635 |
| 248 | NEUROGENESIS | 29 | 1402 | 0.0003016 | 0.005635 |
| 249 | POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 8 | 162 | 0.0003007 | 0.005635 |
| 250 | LONG CHAIN FATTY ACID METABOLIC PROCESS | 6 | 88 | 0.000314 | 0.005822 |
| 251 | NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 6 | 88 | 0.000314 | 0.005822 |
| 252 | INOSITOL LIPID MEDIATED SIGNALING | 7 | 124 | 0.0003205 | 0.005918 |
| 253 | CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 15 | 513 | 0.0003237 | 0.005953 |
| 254 | POSITIVE REGULATION OF CELL PROLIFERATION | 20 | 814 | 0.000338 | 0.006192 |
| 255 | UNSATURATED FATTY ACID BIOSYNTHETIC PROCESS | 5 | 58 | 0.0003396 | 0.006196 |
| 256 | POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS | 13 | 406 | 0.0003456 | 0.006282 |
| 257 | REGULATION OF VESICLE MEDIATED TRANSPORT | 14 | 462 | 0.0003586 | 0.006493 |
| 258 | VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY | 3 | 14 | 0.0003708 | 0.006637 |
| 259 | ARACHIDONIC ACID SECRETION | 3 | 14 | 0.0003708 | 0.006637 |
| 260 | ARACHIDONATE TRANSPORT | 3 | 14 | 0.0003708 | 0.006637 |
| 261 | REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION | 7 | 128 | 0.0003887 | 0.006882 |
| 262 | POSITIVE REGULATION OF LIPID METABOLIC PROCESS | 7 | 128 | 0.0003887 | 0.006882 |
| 263 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 20 | 823 | 0.000389 | 0.006882 |
| 264 | CELL DEVELOPMENT | 29 | 1426 | 0.0003985 | 0.007024 |
| 265 | POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 7 | 129 | 0.0004074 | 0.007154 |
| 266 | TISSUE HOMEOSTASIS | 8 | 171 | 0.0004322 | 0.007545 |
| 267 | RESPONSE TO ABIOTIC STIMULUS | 23 | 1024 | 0.000433 | 0.007545 |
| 268 | BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE | 7 | 131 | 0.0004471 | 0.007762 |
| 269 | POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE | 8 | 172 | 0.0004493 | 0.007771 |
| 270 | CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS | 3 | 15 | 0.00046 | 0.007928 |
| 271 | REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS | 6 | 95 | 0.0004743 | 0.008143 |
| 272 | CELLULAR MACROMOLECULE LOCALIZATION | 26 | 1234 | 0.0004807 | 0.008223 |
| 273 | RESPONSE TO OSMOTIC STRESS | 5 | 63 | 0.0004995 | 0.008513 |
| 274 | POSITIVE REGULATION OF CYTOKINE PRODUCTION | 12 | 370 | 0.00052 | 0.00883 |
| 275 | REGULATION OF EARLY ENDOSOME TO LATE ENDOSOME TRANSPORT | 3 | 16 | 0.0005618 | 0.009472 |
| 276 | RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE | 3 | 16 | 0.0005618 | 0.009472 |
| 277 | ACTIVATION OF MAPK ACTIVITY | 7 | 137 | 0.0005847 | 0.009822 |
| 278 | MYELOID LEUKOCYTE MIGRATION | 6 | 99 | 0.0005909 | 0.009854 |
| 279 | POSITIVE REGULATION OF CELL SUBSTRATE ADHESION | 6 | 99 | 0.0005909 | 0.009854 |
| 280 | POSITIVE REGULATION OF CELL ADHESION | 12 | 376 | 0.0005992 | 0.009958 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | PHOSPHOLIPASE A2 ACTIVITY | 11 | 31 | 8.33e-15 | 7.739e-12 |
| 2 | KINASE ACTIVITY | 33 | 842 | 4.768e-11 | 2.215e-08 |
| 3 | RIBONUCLEOTIDE BINDING | 50 | 1860 | 2.512e-10 | 7.78e-08 |
| 4 | PHOSPHOLIPASE ACTIVITY | 11 | 94 | 3.837e-09 | 7.129e-07 |
| 5 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 33 | 992 | 3.117e-09 | 7.129e-07 |
| 6 | LIPASE ACTIVITY | 11 | 117 | 3.915e-08 | 6.062e-06 |
| 7 | ADENYL NUCLEOTIDE BINDING | 39 | 1514 | 1.114e-07 | 1.478e-05 |
| 8 | CARBOXYLIC ESTER HYDROLASE ACTIVITY | 11 | 135 | 1.716e-07 | 1.944e-05 |
| 9 | ENZYME BINDING | 42 | 1737 | 1.884e-07 | 1.944e-05 |
| 10 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 19 | 445 | 2.218e-07 | 2.061e-05 |
| 11 | PROTEIN KINASE ACTIVITY | 23 | 640 | 2.478e-07 | 2.092e-05 |
| 12 | KINASE BINDING | 22 | 606 | 3.878e-07 | 3.002e-05 |
| 13 | HYDROLASE ACTIVITY ACTING ON ESTER BONDS | 23 | 739 | 2.91e-06 | 0.0002079 |
| 14 | X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 6 | 43 | 5.207e-06 | 0.0003264 |
| 15 | CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY | 4 | 12 | 5.27e-06 | 0.0003264 |
| 16 | PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 7 | 70 | 8.187e-06 | 0.0004754 |
| 17 | PHOSPHATIDYLINOSITOL KINASE ACTIVITY | 6 | 51 | 1.435e-05 | 0.0007844 |
| 18 | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY | 4 | 16 | 1.875e-05 | 0.0009679 |
| 19 | RECEPTOR SIGNALING PROTEIN ACTIVITY | 9 | 172 | 8.15e-05 | 0.003985 |
| 20 | CALMODULIN BINDING | 9 | 179 | 0.0001106 | 0.005136 |
| 21 | INSULIN RECEPTOR SUBSTRATE BINDING | 3 | 11 | 0.000172 | 0.00761 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX | 7 | 20 | 8.221e-10 | 4.801e-07 |
| 2 | EXTRINSIC COMPONENT OF MEMBRANE | 16 | 252 | 9.469e-09 | 2.765e-06 |
| 3 | CELL SUBSTRATE JUNCTION | 16 | 398 | 4.496e-06 | 0.0006565 |
| 4 | CATALYTIC COMPLEX | 28 | 1038 | 3.676e-06 | 0.0006565 |
| 5 | PHOSPHATASE COMPLEX | 6 | 48 | 1.004e-05 | 0.001172 |
| 6 | PERINUCLEAR REGION OF CYTOPLASM | 20 | 642 | 1.321e-05 | 0.001265 |
| 7 | ANCHORING JUNCTION | 17 | 489 | 1.516e-05 | 0.001265 |
| 8 | GOLGI APPARATUS | 32 | 1445 | 3.945e-05 | 0.00288 |
| 9 | LAMELLIPODIUM | 9 | 172 | 8.15e-05 | 0.00476 |
| 10 | CELL LEADING EDGE | 13 | 350 | 8.078e-05 | 0.00476 |
| 11 | TRANSFERASE COMPLEX | 19 | 703 | 0.0001448 | 0.007686 |
| 12 | ENDOPLASMIC RETICULUM TUBULAR NETWORK | 3 | 12 | 0.0002276 | 0.009495 |
| 13 | TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 10 | 237 | 0.000196 | 0.009495 |
| 14 | CYTOPLASMIC REGION | 11 | 287 | 0.0002184 | 0.009495 |
Over-represented Pathway
| Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|---|
| 1 | VEGF_signaling_pathway_hsa04370 | 36 | 59 | 2.016e-57 | 1.048e-55 | |
| 2 | Ras_signaling_pathway_hsa04014 | 34 | 232 | 2.945e-29 | 7.657e-28 | |
| 3 | MAPK_signaling_pathway_hsa04010 | 33 | 295 | 1.546e-24 | 2.558e-23 | |
| 4 | Sphingolipid_signaling_pathway_hsa04071 | 24 | 118 | 1.968e-24 | 2.558e-23 | |
| 5 | Focal_adhesion_hsa04510 | 27 | 199 | 1.876e-22 | 1.781e-21 | |
| 6 | Cellular_senescence_hsa04218 | 25 | 160 | 2.055e-22 | 1.781e-21 | |
| 7 | ErbB_signaling_pathway_hsa04012 | 18 | 85 | 6.297e-19 | 4.678e-18 | |
| 8 | Rap1_signaling_pathway_hsa04015 | 23 | 206 | 2.459e-17 | 1.599e-16 | |
| 9 | Phospholipase_D_signaling_pathway_hsa04072 | 20 | 146 | 5.629e-17 | 3.252e-16 | |
| 10 | cGMP_PKG_signaling_pathway_hsa04022 | 20 | 163 | 5.068e-16 | 2.636e-15 | |
| 11 | Wnt_signaling_pathway_hsa04310 | 18 | 146 | 1.429e-14 | 6.754e-14 | |
| 12 | Regulation_of_actin_cytoskeleton_hsa04810 | 20 | 208 | 5.804e-14 | 2.515e-13 | |
| 13 | cAMP_signaling_pathway_hsa04024 | 19 | 198 | 2.632e-13 | 1.053e-12 | |
| 14 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 16 | 139 | 1.289e-12 | 4.789e-12 | |
| 15 | HIF_1_signaling_pathway_hsa04066 | 14 | 100 | 2.246e-12 | 7.788e-12 | |
| 16 | PI3K_Akt_signaling_pathway_hsa04151 | 23 | 352 | 2.556e-12 | 8.307e-12 | |
| 17 | mTOR_signaling_pathway_hsa04150 | 16 | 151 | 4.682e-12 | 1.432e-11 | |
| 18 | TNF_signaling_pathway_hsa04668 | 14 | 108 | 6.605e-12 | 1.908e-11 | |
| 19 | Autophagy_animal_hsa04140 | 14 | 128 | 6.852e-11 | 1.875e-10 | |
| 20 | FoxO_signaling_pathway_hsa04068 | 14 | 132 | 1.04e-10 | 2.705e-10 | |
| 21 | Apelin_signaling_pathway_hsa04371 | 13 | 137 | 1.972e-09 | 4.882e-09 | |
| 22 | Apoptosis_hsa04210 | 13 | 138 | 2.157e-09 | 5.098e-09 | |
| 23 | Gap_junction_hsa04540 | 10 | 88 | 2.657e-08 | 6.007e-08 | |
| 24 | Phosphatidylinositol_signaling_system_hsa04070 | 10 | 99 | 8.305e-08 | 1.799e-07 | |
| 25 | AMPK_signaling_pathway_hsa04152 | 10 | 121 | 5.531e-07 | 1.151e-06 | |
| 26 | Oocyte_meiosis_hsa04114 | 9 | 124 | 6.049e-06 | 1.21e-05 | |
| 27 | Calcium_signaling_pathway_hsa04020 | 10 | 182 | 2.158e-05 | 4.156e-05 | |
| 28 | Jak_STAT_signaling_pathway_hsa04630 | 9 | 162 | 5.128e-05 | 9.524e-05 | |
| 29 | Mitophagy_animal_hsa04137 | 6 | 65 | 5.834e-05 | 0.0001046 | |
| 30 | Adherens_junction_hsa04520 | 6 | 72 | 0.0001039 | 0.0001801 | |
| 31 | Tight_junction_hsa04530 | 7 | 170 | 0.002051 | 0.00344 | |
| 32 | Necroptosis_hsa04217 | 5 | 164 | 0.02861 | 0.04649 | |
| 33 | Endocytosis_hsa04144 | 6 | 244 | 0.04265 | 0.06721 | |
| 34 | Cell_cycle_hsa04110 | 3 | 124 | 0.1391 | 0.2128 | |
| 35 | Hippo_signaling_pathway_hsa04390 | 3 | 154 | 0.2161 | 0.3142 | |
| 36 | TGF_beta_signaling_pathway_hsa04350 | 2 | 84 | 0.2175 | 0.3142 | |
| 37 | NF_kappa_B_signaling_pathway_hsa04064 | 2 | 95 | 0.2598 | 0.3651 | |
| 38 | Cytokine_cytokine_receptor_interaction_hsa04060 | 4 | 270 | 0.3093 | 0.4124 | |
| 39 | Phagosome_hsa04145 | 2 | 152 | 0.4705 | 0.5826 |
lncRNA-mediated sponge
| Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | TBX5-AS1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-450b-5p;hsa-miR-590-5p;hsa-miR-629-3p | 21 | PIK3R1 | Sponge network | -2.108 | 0 | -1.285 | 0 | 0.544 |
| 2 | AC109642.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-96-5p | 20 | PIK3R1 | Sponge network | -2.791 | 0 | -1.285 | 0 | 0.529 |
| 3 | RP11-389C8.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 18 | PIK3R1 | Sponge network | -2.039 | 0 | -1.285 | 0 | 0.52 |
| 4 | LINC00968 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 22 | PIK3R1 | Sponge network | -4.19 | 0 | -1.285 | 0 | 0.51 |
| 5 | RP11-720L2.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -2.305 | 0 | -1.285 | 0 | 0.496 |
| 6 | LINC00702 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-582-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 26 | PIK3R1 | Sponge network | -2.856 | 0 | -1.285 | 0 | 0.494 |
| 7 | MAGI2-AS3 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 22 | PIK3R1 | Sponge network | -1.892 | 0 | -1.285 | 0 | 0.486 |
| 8 | LINC00702 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-93-5p | 11 | AKT3 | Sponge network | -2.856 | 0 | -1.44 | 0 | 0.485 |
| 9 | LINC00472 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -2.952 | 0 | -1.285 | 0 | 0.458 |
| 10 | AC011899.9 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-24-3p;hsa-miR-29a-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-590-3p | 13 | NFATC2 | Sponge network | -2.611 | 0 | -1.179 | 0.0004 | 0.442 |
| 11 | FENDRR |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 19 | PIK3R1 | Sponge network | -4.222 | 0 | -1.285 | 0 | 0.438 |
| 12 | AC007743.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 17 | PIK3R1 | Sponge network | -2.595 | 0 | -1.285 | 0 | 0.436 |
| 13 | AF131215.2 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-9-5p | 10 | NFATC2 | Sponge network | -2.09 | 0 | -1.179 | 0.0004 | 0.434 |
| 14 | SH3RF3-AS1 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-29a-5p;hsa-miR-30e-5p | 10 | NFATC2 | Sponge network | -1.583 | 0 | -1.179 | 0.0004 | 0.431 |
| 15 | AF131215.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-589-3p | 12 | PIK3R1 | Sponge network | -2.09 | 0 | -1.285 | 0 | 0.428 |
| 16 | RP11-1024P17.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p | 18 | PIK3R1 | Sponge network | -2.062 | 0 | -1.285 | 0 | 0.418 |
| 17 | RP11-400K9.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29b-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.193 | 0.00359 | -1.285 | 0 | 0.418 |
| 18 | RP11-672A2.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-424-5p | 12 | PIK3R1 | Sponge network | -2.68 | 0 | -1.285 | 0 | 0.417 |
| 19 | RP11-456K23.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 23 | PIK3R1 | Sponge network | -1.488 | 0 | -1.285 | 0 | 0.416 |
| 20 | RP11-354E11.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -2.138 | 0 | -1.285 | 0 | 0.41 |
| 21 | RP11-401P9.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-590-5p;hsa-miR-93-5p | 14 | PIK3R1 | Sponge network | -3.04 | 0 | -1.285 | 0 | 0.408 |
| 22 | CTD-2013N24.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 20 | PIK3R1 | Sponge network | -1.745 | 0 | -1.285 | 0 | 0.407 |
| 23 | RP11-532F6.3 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-3p;hsa-miR-629-3p | 15 | PIK3R1 | Sponge network | -2.028 | 0 | -1.285 | 0 | 0.395 |
| 24 | MIR497HG |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 23 | PIK3R1 | Sponge network | -2.142 | 0 | -1.285 | 0 | 0.391 |
| 25 | RP11-456K23.1 |
hsa-miR-106b-5p;hsa-miR-146b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-22-3p;hsa-miR-28-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-542-3p;hsa-miR-93-5p | 14 | AKT3 | Sponge network | -1.488 | 0 | -1.44 | 0 | 0.389 |
| 26 | TBX5-AS1 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-28-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-542-3p | 12 | AKT3 | Sponge network | -2.108 | 0 | -1.44 | 0 | 0.386 |
| 27 | MAGI2-AS3 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-93-5p | 11 | AKT3 | Sponge network | -1.892 | 0 | -1.44 | 0 | 0.386 |
| 28 | RP11-399O19.9 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -0.873 | 0.00072 | -1.285 | 0 | 0.38 |
| 29 | FGF14-AS2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | -2.159 | 0 | -1.285 | 0 | 0.378 |
| 30 | TBX5-AS1 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-9-5p | 13 | NFATC2 | Sponge network | -2.108 | 0 | -1.179 | 0.0004 | 0.376 |
| 31 | HHIP-AS1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p | 15 | PIK3R1 | Sponge network | -2.807 | 0 | -1.285 | 0 | 0.374 |
| 32 | LINC00472 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-335-3p | 10 | NFATC2 | Sponge network | -2.952 | 0 | -1.179 | 0.0004 | 0.372 |
| 33 | LINC00092 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p | 14 | PIK3R1 | Sponge network | -2.383 | 0 | -1.285 | 0 | 0.369 |
| 34 | RP11-378A13.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 17 | PIK3R1 | Sponge network | -1.713 | 0 | -1.285 | 0 | 0.367 |
| 35 | CTD-2013N24.2 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-20a-5p;hsa-miR-22-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-93-5p | 13 | AKT3 | Sponge network | -1.745 | 0 | -1.44 | 0 | 0.366 |
| 36 | SH3RF3-AS1 |
hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-582-5p;hsa-miR-590-5p | 15 | PIK3R1 | Sponge network | -1.583 | 0 | -1.285 | 0 | 0.364 |
| 37 | AC011899.9 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p | 16 | PIK3R1 | Sponge network | -2.611 | 0 | -1.285 | 0 | 0.364 |
| 38 | RP11-389C8.2 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-590-3p | 12 | NFATC2 | Sponge network | -2.039 | 0 | -1.179 | 0.0004 | 0.363 |
| 39 | AC079630.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -3.758 | 0 | -1.285 | 0 | 0.359 |
| 40 | RP5-1042I8.7 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 14 | PIK3R1 | Sponge network | -0.733 | 0.00018 | -1.285 | 0 | 0.358 |
| 41 | AC003090.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 17 | PIK3R1 | Sponge network | -3.16 | 2.0E-5 | -1.285 | 0 | 0.358 |
| 42 | MAGI2-AS3 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-9-5p | 14 | NFATC2 | Sponge network | -1.892 | 0 | -1.179 | 0.0004 | 0.357 |
| 43 | GAS6-AS2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-5p | 17 | PIK3R1 | Sponge network | -1.761 | 0 | -1.285 | 0 | 0.354 |
| 44 | LINC00968 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-29a-5p;hsa-miR-320b;hsa-miR-590-3p;hsa-miR-9-5p | 13 | NFATC2 | Sponge network | -4.19 | 0 | -1.179 | 0.0004 | 0.353 |
| 45 | RP11-1024P17.1 |
hsa-miR-17-3p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-193b-3p;hsa-miR-193b-5p;hsa-miR-19b-1-5p;hsa-miR-200c-3p;hsa-miR-22-5p;hsa-miR-24-2-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-3p | 12 | PRKCA | Sponge network | -2.062 | 0 | -0.19 | 0.47108 | 0.349 |
| 46 | LINC00702 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-30e-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-3613-5p;hsa-miR-590-3p | 15 | NFATC2 | Sponge network | -2.856 | 0 | -1.179 | 0.0004 | 0.348 |
| 47 | RP11-532F6.3 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-590-3p;hsa-miR-9-5p | 11 | NFATC2 | Sponge network | -2.028 | 0 | -1.179 | 0.0004 | 0.347 |
| 48 | LINC00961 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-96-5p | 15 | PIK3R1 | Sponge network | -2.724 | 0 | -1.285 | 0 | 0.346 |
| 49 | RBMS3-AS3 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-629-3p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -2.307 | 0.0011 | -1.285 | 0 | 0.345 |
| 50 | AC010226.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -1.081 | 2.0E-5 | -1.285 | 0 | 0.344 |
| 51 | LINC00987 | hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-93-5p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -0.927 | 0 | -1.285 | 0 | 0.343 |
| 52 | BZRAP1-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -0.785 | 0.00723 | -1.285 | 0 | 0.34 |
| 53 | AC109642.1 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-320b;hsa-miR-590-3p;hsa-miR-9-5p | 14 | NFATC2 | Sponge network | -2.791 | 0 | -1.179 | 0.0004 | 0.339 |
| 54 | AC011526.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -2.783 | 0 | -1.285 | 0 | 0.338 |
| 55 | AC004947.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 17 | PIK3R1 | Sponge network | -3.94 | 0 | -1.285 | 0 | 0.332 |
| 56 | CTC-523E23.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-590-3p | 11 | PIK3R1 | Sponge network | -1.636 | 0.00051 | -1.285 | 0 | 0.33 |
| 57 | WDFY3-AS2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -1.297 | 0 | -1.285 | 0 | 0.329 |
| 58 | CTD-2003C8.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-590-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -3.403 | 0 | -1.285 | 0 | 0.328 |
| 59 | LINC00883 | hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p | 12 | PIK3R1 | Sponge network | -1.466 | 0 | -1.285 | 0 | 0.327 |
| 60 | RP11-284N8.3 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-24-3p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-590-3p | 12 | NFATC2 | Sponge network | -0.761 | 0.05061 | -1.179 | 0.0004 | 0.323 |
| 61 | RP11-293M10.6 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -1.199 | 0.00063 | -1.285 | 0 | 0.32 |
| 62 | RP11-434D9.1 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -4.573 | 0 | -1.285 | 0 | 0.319 |
| 63 | NR2F1-AS1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 18 | PIK3R1 | Sponge network | -0.427 | 0.1559 | -1.285 | 0 | 0.318 |
| 64 | CTC-559E9.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.737 | 0.0562 | -1.285 | 0 | 0.318 |
| 65 | RP11-789C1.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -4.664 | 0.00012 | -1.285 | 0 | 0.317 |
| 66 | LINC00607 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p | 15 | PIK3R1 | Sponge network | -2.277 | 0 | -1.285 | 0 | 0.316 |
| 67 | RP11-517P14.2 | hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.795 | 6.0E-5 | -1.285 | 0 | 0.315 |
| 68 | RP4-639F20.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -1.312 | 0 | -1.285 | 0 | 0.314 |
| 69 | RP11-244O19.1 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -0.428 | 0.21699 | -1.285 | 0 | 0.303 |
| 70 | RP11-462G12.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -1.071 | 0.01175 | -1.285 | 0 | 0.302 |
| 71 | CTD-2013N24.2 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-29a-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-590-3p | 10 | NFATC2 | Sponge network | -1.745 | 0 | -1.179 | 0.0004 | 0.301 |
| 72 | LINC01088 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.385 | 0.01604 | -1.285 | 0 | 0.3 |
| 73 | AC016735.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-582-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -2.711 | 0.00282 | -1.285 | 0 | 0.298 |
| 74 | RP11-67L2.2 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -1.062 | 0 | -1.285 | 0 | 0.298 |
| 75 | RP11-88I21.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -8.789 | 0 | -1.285 | 0 | 0.297 |
| 76 | RP11-1008C21.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-629-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -1.249 | 0 | -1.285 | 0 | 0.297 |
| 77 | AC034187.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.974 | 0 | -1.285 | 0 | 0.297 |
| 78 | RP11-365O16.3 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -2.765 | 0.00017 | -1.285 | 0 | 0.293 |
| 79 | RP4-647J21.1 |
hsa-miR-17-3p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-193b-3p;hsa-miR-193b-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-92a-3p;hsa-miR-93-3p | 10 | PRKCA | Sponge network | -0.153 | 0.73575 | -0.19 | 0.47108 | 0.293 |
| 80 | CASC2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -1.086 | 0 | -1.285 | 0 | 0.29 |
| 81 | GAS6-AS2 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-2355-5p;hsa-miR-29a-5p;hsa-miR-335-3p | 11 | NFATC2 | Sponge network | -1.761 | 0 | -1.179 | 0.0004 | 0.285 |
| 82 | RP11-284N8.3 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -0.761 | 0.05061 | -1.285 | 0 | 0.285 |
| 83 | AF131215.9 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-3p | 12 | PIK3R1 | Sponge network | -1.808 | 0 | -1.285 | 0 | 0.282 |
| 84 | RP11-352D13.6 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 15 | PIK3R1 | Sponge network | -4.634 | 0 | -1.285 | 0 | 0.28 |
| 85 | LIPE-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-5p;hsa-miR-93-5p | 14 | PIK3R1 | Sponge network | -0.734 | 0.00039 | -1.285 | 0 | 0.28 |
| 86 | RP11-354E11.2 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-9-5p | 13 | NFATC2 | Sponge network | -2.138 | 0 | -1.179 | 0.0004 | 0.28 |
| 87 | RP11-476D10.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -4.519 | 0 | -1.285 | 0 | 0.279 |
| 88 | BDNF-AS | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -0.568 | 0.02011 | -1.285 | 0 | 0.277 |
| 89 | CTD-2135D7.5 | hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-5p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -3.162 | 0 | -1.285 | 0 | 0.277 |
| 90 | CTC-441N14.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-582-5p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | -2.273 | 0.01231 | -1.285 | 0 | 0.276 |
| 91 | LINC00443 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p | 14 | PIK3R1 | Sponge network | -3.704 | 0.0003 | -1.285 | 0 | 0.276 |
| 92 | AC008268.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -5.661 | 0 | -1.285 | 0 | 0.276 |
| 93 | RP11-1008C21.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p | 13 | PIK3R1 | Sponge network | -1.826 | 3.0E-5 | -1.285 | 0 | 0.272 |
| 94 | MAGI2-AS3 |
hsa-miR-17-3p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-193b-3p;hsa-miR-193b-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-22-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-93-3p | 13 | PRKCA | Sponge network | -1.892 | 0 | -0.19 | 0.47108 | 0.271 |
| 95 | SNHG18 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.073 | 0.00533 | -1.285 | 0 | 0.27 |
| 96 | C1orf132 |
hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -0.86 | 0.02429 | -1.285 | 0 | 0.269 |
| 97 | LINC00551 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-629-3p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -2.179 | 0.00466 | -1.285 | 0 | 0.269 |
| 98 | LINC01024 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -0.659 | 0.02711 | -1.285 | 0 | 0.266 |
| 99 | CTC-366B18.4 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.652 | 0.01265 | -1.285 | 0 | 0.265 |
| 100 | RP1-78O14.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -4.409 | 0 | -1.285 | 0 | 0.264 |
| 101 | AC096670.3 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -1.939 | 7.0E-5 | -1.285 | 0 | 0.263 |
| 102 | RP5-839B4.8 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-629-3p;hsa-miR-93-5p | 14 | PIK3R1 | Sponge network | -5.037 | 0 | -1.285 | 0 | 0.262 |
| 103 | RP11-1024P17.1 |
hsa-miR-130b-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-29a-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-9-5p | 12 | NFATC2 | Sponge network | -2.062 | 0 | -1.179 | 0.0004 | 0.262 |
| 104 | DIO3OS | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-629-3p | 14 | PIK3R1 | Sponge network | -1.936 | 0.00085 | -1.285 | 0 | 0.262 |
| 105 | CTC-523E23.1 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-3p;hsa-miR-629-3p | 10 | PIK3R1 | Sponge network | -1.223 | 0.0005 | -1.285 | 0 | 0.262 |
| 106 | RP4-668J24.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -2.397 | 0.00331 | -1.285 | 0 | 0.261 |
| 107 | RP11-347J14.7 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -5.394 | 0 | -1.285 | 0 | 0.261 |
| 108 | LINC00261 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p | 17 | PIK3R1 | Sponge network | -2.566 | 0.00025 | -1.285 | 0 | 0.259 |
| 109 | HHIP-AS1 |
hsa-miR-130b-5p;hsa-miR-16-2-3p;hsa-miR-185-5p;hsa-miR-193b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-590-3p | 10 | NFATC2 | Sponge network | -2.807 | 0 | -1.179 | 0.0004 | 0.256 |
| 110 | AGAP11 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -2.127 | 0 | -1.285 | 0 | 0.255 |
| 111 | LINC00619 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p | 11 | PIK3R1 | Sponge network | -2.307 | 0.02217 | -1.285 | 0 | 0.255 |
| 112 | DNM3OS | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p | 16 | PIK3R1 | Sponge network | 0.053 | 0.85755 | -1.285 | 0 | 0.255 |
| 113 | CTA-221G9.11 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -0.645 | 0.06404 | -1.285 | 0 | 0.254 |
| 114 | PCED1B-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-335-3p;hsa-miR-93-5p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | -0.672 | 0.02084 | -1.285 | 0 | 0.254 |
| 115 | RP11-677M14.3 | hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -1.866 | 0 | -1.285 | 0 | 0.251 |