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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-150-5p HNF1A -0.7 0.02153 1.32 0.00515 mirMAP -0.18 0.01322 NA
2 hsa-miR-15b-5p HNF1A -1.26 0 1.32 0.00515 mirMAP -0.31 0.00927 NA
3 hsa-miR-195-5p HNF1A -1.02 5.0E-5 1.32 0.00515 mirMAP -0.34 0.00016 NA
4 hsa-miR-214-3p HNF1A -1.11 4.0E-5 1.32 0.00515 MirTarget -0.29 0.00034 NA
5 hsa-miR-218-5p HNF1A -0.28 0.25955 1.32 0.00515 mirMAP -0.28 0.00174 NA
6 hsa-miR-221-5p HNF1A -2.22 0 1.32 0.00515 mirMAP -0.37 0 NA
7 hsa-miR-34c-5p HNF1A -1 0.07244 1.32 0.00515 miRanda; mirMAP -0.1 0.01109 NA
8 hsa-miR-424-5p HNF1A 1.26 1.0E-5 1.32 0.00515 mirMAP -0.21 0.00565 NA
9 hsa-miR-542-3p HNF1A 1.62 0 1.32 0.00515 miRanda -0.36 2.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELLULAR COMPONENT MOVEMENT 20 771 1.65e-10 7.679e-07
2 CELL ACTIVATION 16 568 4.466e-09 7.72e-06
3 ORGAN MORPHOGENESIS 19 841 4.978e-09 7.72e-06
4 LEUKOCYTE ACTIVATION 13 414 4.12e-08 3.316e-05
5 LYMPHOCYTE ACTIVATION 12 342 4.276e-08 3.316e-05
6 LYMPHOCYTE DIFFERENTIATION 10 209 3.461e-08 3.316e-05
7 REGULATION OF EPITHELIAL CELL MIGRATION 9 166 5.975e-08 3.66e-05
8 MORPHOGENESIS OF A BRANCHING STRUCTURE 9 167 6.293e-08 3.66e-05
9 SINGLE ORGANISM CELL ADHESION 13 459 1.364e-07 6.347e-05
10 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 8 131 1.35e-07 6.347e-05
11 WOUND HEALING 13 470 1.79e-07 6.942e-05
12 TUBE DEVELOPMENT 14 552 1.664e-07 6.942e-05
13 RESPONSE TO WOUNDING 14 563 2.115e-07 7.571e-05
14 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 15 689 4.088e-07 0.0001119
15 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 13 498 3.465e-07 0.0001119
16 CARDIOVASCULAR SYSTEM DEVELOPMENT 16 788 4.072e-07 0.0001119
17 CIRCULATORY SYSTEM DEVELOPMENT 16 788 4.072e-07 0.0001119
18 POSITIVE REGULATION OF GENE EXPRESSION 24 1733 4.363e-07 0.0001128
19 LEUKOCYTE DIFFERENTIATION 10 292 7.71e-07 0.0001888
20 EPITHELIUM DEVELOPMENT 17 945 9.108e-07 0.0002119
21 T CELL DIFFERENTIATION 7 123 1.372e-06 0.000304
22 CELL PROLIFERATION 14 672 1.745e-06 0.000369
23 IMMUNE SYSTEM DEVELOPMENT 13 582 1.982e-06 0.000401
24 LEUKOCYTE CELL CELL ADHESION 9 255 2.222e-06 0.0004308
25 POSITIVE REGULATION OF LOCOMOTION 11 420 2.886e-06 0.0005112
26 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 20 1395 2.967e-06 0.0005112
27 TISSUE DEVELOPMENT 21 1518 2.797e-06 0.0005112
28 CELL CELL ADHESION 13 608 3.202e-06 0.0005174
29 MESONEPHROS DEVELOPMENT 6 90 3.225e-06 0.0005174
30 REGULATION OF CELL ADHESION 13 629 4.632e-06 0.0007184
31 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 6 103 7.067e-06 0.001061
32 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 6 104 7.473e-06 0.001087
33 LOCOMOTION 17 1114 8.337e-06 0.001128
34 VASCULATURE DEVELOPMENT 11 469 8.235e-06 0.001128
35 REGULATION OF CELL PROLIFERATION 20 1496 8.483e-06 0.001128
36 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 16 1004 9.342e-06 0.001208
37 MORPHOGENESIS OF AN EPITHELIUM 10 400 1.261e-05 0.001416
38 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 5 67 1.278e-05 0.001416
39 REGULATION OF ENDOTHELIAL CELL MIGRATION 6 114 1.267e-05 0.001416
40 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 21 1672 1.254e-05 0.001416
41 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 18 1275 1.259e-05 0.001416
42 GLAND DEVELOPMENT 10 395 1.131e-05 0.001416
43 BIOLOGICAL ADHESION 16 1032 1.316e-05 0.001424
44 TUBE MORPHOGENESIS 9 323 1.499e-05 0.001585
45 DEVELOPMENTAL GROWTH 9 333 1.908e-05 0.001973
46 RESPONSE TO ENDOGENOUS STIMULUS 19 1450 1.979e-05 0.002001
47 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 5 74 2.08e-05 0.00206
48 KIDNEY EPITHELIUM DEVELOPMENT 6 125 2.142e-05 0.002077
49 TISSUE MORPHOGENESIS 11 533 2.699e-05 0.002563
50 DENDRITE DEVELOPMENT 5 79 2.86e-05 0.002661
51 REGULATION OF CELL DIFFERENTIATION 19 1492 2.94e-05 0.002682
52 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 7 197 3.029e-05 0.002683
53 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 15 983 3.056e-05 0.002683
54 POSITIVE REGULATION OF RESPONSE TO STIMULUS 22 1929 3.348e-05 0.002832
55 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 21 1784 3.322e-05 0.002832
56 KIDNEY MORPHOGENESIS 5 82 3.426e-05 0.002846
57 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 20 1656 3.715e-05 0.003033
58 NEUROGENESIS 18 1402 4.459e-05 0.003578
59 POSITIVE REGULATION OF MAPK CASCADE 10 470 4.978e-05 0.003639
60 POSITIVE REGULATION OF HYDROLASE ACTIVITY 14 905 5.005e-05 0.003639
61 THYMOCYTE AGGREGATION 4 45 4.961e-05 0.003639
62 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 7 213 4.978e-05 0.003639
63 HEART DEVELOPMENT 10 466 4.634e-05 0.003639
64 T CELL DIFFERENTIATION IN THYMUS 4 45 4.961e-05 0.003639
65 REGULATION OF CELL CELL ADHESION 9 380 5.344e-05 0.003826
66 BRANCH ELONGATION OF AN EPITHELIUM 3 17 5.725e-05 0.003986
67 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 13 799 5.739e-05 0.003986
68 UROGENITAL SYSTEM DEVELOPMENT 8 299 6.092e-05 0.004169
69 NEGATIVE REGULATION OF CELL ADHESION 7 223 6.648e-05 0.004483
70 FC GAMMA RECEPTOR SIGNALING PATHWAY 5 95 6.948e-05 0.004618
71 EPITHELIAL CELL DIFFERENTIATION 10 495 7.665e-05 0.005023
72 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 98 8.058e-05 0.005067
73 PROTEIN PHOSPHORYLATION 14 944 7.872e-05 0.005067
74 NEGATIVE REGULATION OF CELL ACTIVATION 6 158 7.963e-05 0.005067
75 REGULATION OF CELL DEATH 18 1472 8.378e-05 0.005198
76 CELL MOTILITY 13 835 8.962e-05 0.00521
77 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 9 406 8.87e-05 0.00521
78 LOCALIZATION OF CELL 13 835 8.962e-05 0.00521
79 EMBRYONIC ORGAN DEVELOPMENT 9 406 8.87e-05 0.00521
80 REGULATION OF CELL DEVELOPMENT 13 836 9.07e-05 0.00521
81 NEGATIVE REGULATION OF CELL DIFFERENTIATION 11 609 8.971e-05 0.00521
82 MESONEPHRIC TUBULE MORPHOGENESIS 4 53 9.486e-05 0.005357
83 GROWTH 9 410 9.556e-05 0.005357
84 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 55 0.0001097 0.006078
85 POSITIVE REGULATION OF MOLECULAR FUNCTION 20 1791 0.000111 0.006078
86 POSITIVE REGULATION OF CELL CELL ADHESION 7 243 0.0001137 0.006152
87 POSITIVE REGULATION OF CATALYTIC ACTIVITY 18 1518 0.0001239 0.006628
88 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 13 867 0.0001305 0.006898
89 POSITIVE REGULATION OF CELL COMMUNICATION 18 1532 0.0001391 0.007114
90 NEGATIVE REGULATION OF CELL DEATH 13 872 0.0001381 0.007114
91 CENTRAL NERVOUS SYSTEM DEVELOPMENT 13 872 0.0001381 0.007114
92 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 13 876 0.0001445 0.007308
93 IMMUNE SYSTEM PROCESS 21 1984 0.0001539 0.007544
94 REGULATION OF IMMUNE SYSTEM PROCESS 17 1403 0.0001523 0.007544
95 EMBRYONIC MORPHOGENESIS 10 539 0.000154 0.007544
96 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 14 1008 0.0001571 0.007615
97 NEGATIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 4 61 0.0001645 0.007833
98 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 15 1142 0.000165 0.007833
99 RESPONSE TO HORMONE 13 893 0.0001746 0.008208
100 REGULATION OF MAPK CASCADE 11 660 0.0001815 0.008281
101 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 15 1152 0.0001814 0.008281
102 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 14 1021 0.0001795 0.008281
103 LENS FIBER CELL DIFFERENTIATION 3 25 0.0001886 0.00836
104 NEGATIVE REGULATION OF LOCOMOTION 7 263 0.0001852 0.00836
105 CELLULAR COMPONENT MORPHOGENESIS 13 900 0.0001885 0.00836
106 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 1036 0.0002087 0.009075
107 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1036 0.0002087 0.009075
108 MESENCHYME DEVELOPMENT 6 190 0.0002182 0.009402
109 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 0.0002233 0.009533
110 BLOOD VESSEL MORPHOGENESIS 8 364 0.0002359 0.009978
111 AXIS ELONGATION 3 27 0.0002384 0.009992
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 SIDE OF MEMBRANE 13 428 6.072e-08 3.546e-05
2 CELL SURFACE 15 757 1.331e-06 0.0003887
3 VACUOLE 18 1180 4.342e-06 0.0008452
4 BASAL PLASMA MEMBRANE 4 33 1.42e-05 0.001658
5 EXTERNAL SIDE OF PLASMA MEMBRANE 8 238 1.197e-05 0.001658
6 MEMBRANE REGION 16 1134 4.156e-05 0.004045
7 EARLY ENDOSOME 8 301 6.383e-05 0.005326
8 BASAL PART OF CELL 4 51 8.151e-05 0.00595

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04014_Ras_signaling_pathway 8 236 1.126e-05 0.002026
2 hsa04650_Natural_killer_cell_mediated_cytotoxicity 6 136 3.45e-05 0.003105
3 hsa04380_Osteoclast_differentiation 5 128 0.0002824 0.01185
4 hsa04510_Focal_adhesion 6 200 0.0002876 0.01185
5 hsa04520_Adherens_junction 4 73 0.0003293 0.01185
6 hsa04664_Fc_epsilon_RI_signaling_pathway 4 79 0.0004453 0.01336
7 hsa04390_Hippo_signaling_pathway 5 154 0.0006585 0.01693
8 hsa04666_Fc_gamma_R.mediated_phagocytosis 4 95 0.0008933 0.0201
9 hsa04670_Leukocyte_transendothelial_migration 4 117 0.00193 0.0386
10 hsa04360_Axon_guidance 4 130 0.002829 0.05092
11 hsa04910_Insulin_signaling_pathway 4 138 0.003506 0.05737
12 hsa04012_ErbB_signaling_pathway 3 87 0.007113 0.1048
13 hsa04210_Apoptosis 3 89 0.007572 0.1048
14 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.01281 0.1647
15 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.01534 0.1775
16 hsa04810_Regulation_of_actin_cytoskeleton 4 214 0.01593 0.1775
17 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.01676 0.1775
18 hsa04722_Neurotrophin_signaling_pathway 3 127 0.01968 0.1968
19 hsa04150_mTOR_signaling_pathway 2 52 0.02295 0.2117
20 hsa04514_Cell_adhesion_molecules_.CAMs. 3 136 0.02352 0.2117
21 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.04496 0.3767
22 hsa04370_VEGF_signaling_pathway 2 76 0.04605 0.3767
23 hsa04070_Phosphatidylinositol_signaling_system 2 78 0.04824 0.3775
24 hsa04062_Chemokine_signaling_pathway 3 189 0.05371 0.4028
25 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.05857 0.4217
26 hsa04144_Endocytosis 3 203 0.06376 0.4414
27 hsa04151_PI3K_AKT_signaling_pathway 4 351 0.07387 0.4585
28 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.07727 0.4636
29 hsa04010_MAPK_signaling_pathway 3 268 0.1202 0.587
30 hsa04530_Tight_junction 2 133 0.1207 0.587
31 hsa04630_Jak.STAT_signaling_pathway 2 155 0.1543 0.7013
32 hsa04145_Phagosome 2 156 0.1558 0.7013

Quest ID: cf3fdba633943ece59c651176cac575f