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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-142-3p ABCC9 1.13 0 -0.52 0.04626 miRNAWalker2 validate -0.25 1.0E-5 NA
2 hsa-miR-142-3p ACSL1 1.13 0 -1.24 0 PITA; miRanda -0.12 0.00013 NA
3 hsa-miR-142-3p ACTN1 1.13 0 0.8 0 miRanda -0.12 0.00098 NA
4 hsa-miR-142-3p ACVR1 1.13 0 0.7 0 miRanda -0.16 0 NA
5 hsa-miR-142-3p ACVR2A 1.13 0 -0.89 0 MirTarget; PITA; miRanda; miRNATAP -0.11 2.0E-5 NA
6 hsa-miR-142-3p ADAMTS3 1.13 0 0.25 0.32288 PITA; miRanda; miRNATAP -0.13 0.01332 NA
7 hsa-miR-142-3p ADAMTS5 1.13 0 0.22 0.3564 PITA; miRanda -0.27 0 NA
8 hsa-miR-142-3p ADRA2C 1.13 0 0.19 0.51334 miRanda -0.33 0 NA
9 hsa-miR-142-3p AK5 1.13 0 0.65 0.03015 miRanda -0.35 0 NA
10 hsa-miR-142-3p AKAP6 1.13 0 -2.06 0 miRanda -0.38 0 NA
11 hsa-miR-142-3p AKNAD1 1.13 0 0.54 0.12072 miRanda -0.19 0.01273 NA
12 hsa-miR-142-3p ALDH1A2 1.13 0 -2.71 0 PITA; miRanda -0.23 0.00185 NA
13 hsa-miR-142-3p AMN1 1.13 0 -0.18 0.12953 miRanda -0.1 7.0E-5 NA
14 hsa-miR-142-3p AMOTL1 1.13 0 -0.32 0.02522 miRanda; miRNATAP -0.13 3.0E-5 NA
15 hsa-miR-142-3p AMPH 1.13 0 0.35 0.19936 miRanda -0.2 0.00071 NA
16 hsa-miR-142-3p ANK2 1.13 0 -2.53 0 miRanda -0.13 0.04902 NA
17 hsa-miR-142-3p ANO7 1.13 0 0.93 0 miRanda -0.12 0.00242 NA
18 hsa-miR-142-3p APOD 1.13 0 -3.16 0 miRanda -0.29 6.0E-5 NA
19 hsa-miR-142-3p ARG1 1.13 0 -1.89 0.0006 miRanda -0.26 0.03156 NA
20 hsa-miR-142-3p ARHGEF10 1.13 0 0.14 0.38973 miRanda -0.17 0 NA
21 hsa-miR-142-3p ARMCX3 1.13 0 -0.55 0.00471 miRanda -0.15 0.00028 NA
22 hsa-miR-142-3p ASPH 1.13 0 0.03 0.80132 miRanda -0.11 2.0E-5 NA
23 hsa-miR-142-3p ATP1A2 1.13 0 -4.55 0 miRanda -0.45 0.00013 NA
24 hsa-miR-142-3p ATP1B1 1.13 0 -0.73 0 PITA; miRanda; miRNATAP -0.11 0.00097 NA
25 hsa-miR-142-3p ATRN 1.13 0 0.26 0.00951 miRanda -0.15 0 NA
26 hsa-miR-142-3p BACH2 1.13 0 -0.4 0.0643 MirTarget; PITA; miRNATAP -0.13 0.00632 NA
27 hsa-miR-142-3p BAHCC1 1.13 0 0.16 0.32112 miRanda -0.17 0 NA
28 hsa-miR-142-3p BHLHB9 1.13 0 -0.25 0.1027 miRanda -0.12 0.00043 NA
29 hsa-miR-142-3p BMP4 1.13 0 -1.05 0 PITA; miRanda -0.16 0.00028 NA
30 hsa-miR-142-3p BNC2 1.13 0 -1.1 3.0E-5 MirTarget; PITA; miRanda; miRNATAP -0.22 9.0E-5 NA
31 hsa-miR-142-3p BNIP3 1.13 0 0.33 0.06029 miRanda -0.14 0.00017 NA
32 hsa-miR-142-3p BOC 1.13 0 -2.04 0 miRanda -0.2 1.0E-5 NA
33 hsa-miR-142-3p BVES 1.13 0 0.15 0.56319 miRanda -0.15 0.01059 NA
34 hsa-miR-142-3p C20orf194 1.13 0 -0.08 0.53682 PITA; miRNATAP -0.15 0 NA
35 hsa-miR-142-3p CA3 1.13 0 -4.67 0 miRanda -0.36 0.00144 NA
36 hsa-miR-142-3p CACNA2D2 1.13 0 -1.39 0 miRanda -0.12 0.01278 NA
37 hsa-miR-142-3p CALD1 1.13 0 0.87 0 miRanda -0.16 1.0E-5 NA
38 hsa-miR-142-3p CALU 1.13 0 0.94 0 miRanda -0.12 0 NA
39 hsa-miR-142-3p CAV1 1.13 0 1.39 0 miRanda -0.11 0.03125 NA
40 hsa-miR-142-3p CCDC3 1.13 0 0.5 0.0142 miRanda -0.19 1.0E-5 NA
41 hsa-miR-142-3p CCND1 1.13 0 -0.01 0.95947 miRanda -0.21 0 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil
42 hsa-miR-142-3p CDH19 1.13 0 -3.27 0 miRanda -0.34 0.0001 NA
43 hsa-miR-142-3p CFL2 1.13 0 -1.08 0 MirTarget; PITA; miRanda; miRNATAP -0.13 0.00056 NA
44 hsa-miR-142-3p CGNL1 1.13 0 -3.51 0 miRanda -0.15 0.02321 NA
45 hsa-miR-142-3p CLDN20 1.13 0 -0.29 0.44335 miRanda -0.23 0.00479 NA
46 hsa-miR-142-3p CLYBL 1.13 0 -1.8 0 miRanda -0.12 0.0017 NA
47 hsa-miR-142-3p CMBL 1.13 0 0.16 0.4071 miRanda -0.13 0.00092 NA
48 hsa-miR-142-3p COL12A1 1.13 0 2.79 0 miRanda -0.22 0.00011 NA
49 hsa-miR-142-3p COL24A1 1.13 0 1.7 0 PITA; miRanda; miRNATAP -0.24 5.0E-5 NA
50 hsa-miR-142-3p COL8A1 1.13 0 1.67 0 miRanda -0.28 6.0E-5 NA
51 hsa-miR-142-3p COPS7A 1.13 0 -0.05 0.4704 miRanda; miRNATAP -0.11 0 NA
52 hsa-miR-142-3p CORIN 1.13 0 -0.02 0.9247 miRanda -0.24 0 NA
53 hsa-miR-142-3p CPE 1.13 0 -0.35 0.0982 miRanda -0.17 0.00015 NA
54 hsa-miR-142-3p CREB5 1.13 0 -0.06 0.77912 miRNATAP -0.17 0.00027 NA
55 hsa-miR-142-3p CRIM1 1.13 0 -0.17 0.27799 miRanda -0.15 1.0E-5 NA
56 hsa-miR-142-3p CRK 1.13 0 -0.08 0.34592 PITA; miRanda; miRNATAP -0.12 0 NA
57 hsa-miR-142-3p CSRP1 1.13 0 -0.45 0 miRanda -0.1 0 NA
58 hsa-miR-142-3p CTTN 1.13 0 0.48 0.0092 miRNATAP -0.11 0.00435 NA
59 hsa-miR-142-3p CYP46A1 1.13 0 -0.02 0.9291 miRanda -0.21 2.0E-5 NA
60 hsa-miR-142-3p DAAM1 1.13 0 -0.37 0.02951 miRanda -0.12 0.001 NA
61 hsa-miR-142-3p DLX2 1.13 0 2.59 0 miRanda -0.28 0.00028 NA
62 hsa-miR-142-3p DMRT2 1.13 0 -1 0.02224 miRanda -0.32 0.00065 NA
63 hsa-miR-142-3p DMRT3 1.13 0 -0.6 0.09593 miRanda -0.26 0.00065 NA
64 hsa-miR-142-3p DNAJB4 1.13 0 -0.41 0.00381 miRNAWalker2 validate -0.17 0 NA
65 hsa-miR-142-3p DOCK3 1.13 0 -1.87 0 miRanda -0.11 0.03601 NA
66 hsa-miR-142-3p DOCK9 1.13 0 -0.93 0 miRanda -0.11 0.00047 NA
67 hsa-miR-142-3p DSEL 1.13 0 -0.1 0.62412 miRanda -0.24 0 NA
68 hsa-miR-142-3p DTNA 1.13 0 -1.89 0 miRanda; miRNATAP -0.32 1.0E-5 NA
69 hsa-miR-142-3p EBF1 1.13 0 -0.41 0.03046 miRanda -0.1 0.01292 NA
70 hsa-miR-142-3p ECM2 1.13 0 -0.1 0.62527 miRanda; miRNATAP -0.2 0 NA
71 hsa-miR-142-3p EGFR 1.13 0 0.42 0.07321 miRanda -0.21 3.0E-5 NA
72 hsa-miR-142-3p EHBP1 1.13 0 -0.06 0.56297 miRanda -0.11 0 NA
73 hsa-miR-142-3p EMX2 1.13 0 -0.61 0.04956 miRanda -0.33 0 NA
74 hsa-miR-142-3p EN1 1.13 0 4.47 0 miRanda -0.25 0.00782 NA
75 hsa-miR-142-3p ESRRG 1.13 0 -3.91 0 miRanda -0.4 1.0E-5 NA
76 hsa-miR-142-3p ETNK2 1.13 0 -0.88 0.0002 miRNAWalker2 validate -0.21 4.0E-5 NA
77 hsa-miR-142-3p ETV3 1.13 0 -0.57 0.00837 miRanda -0.12 0.00939 NA
78 hsa-miR-142-3p FAH 1.13 0 -0.02 0.88242 miRanda -0.12 2.0E-5 NA
79 hsa-miR-142-3p FAM114A1 1.13 0 -0.49 0.00044 MirTarget; miRanda; miRNATAP -0.15 0 NA
80 hsa-miR-142-3p FAM127A 1.13 0 0.18 0.12469 miRanda; miRNATAP -0.12 0 NA
81 hsa-miR-142-3p FAM133A 1.13 0 0.45 0.31985 miRanda -0.48 0 NA
82 hsa-miR-142-3p FAM13C 1.13 0 -1.91 0 miRanda -0.21 0.00046 NA
83 hsa-miR-142-3p FAM171B 1.13 0 -0.22 0.32215 miRanda -0.32 0 NA
84 hsa-miR-142-3p FAM196B 1.13 0 -0.45 0.15333 miRanda -0.27 7.0E-5 NA
85 hsa-miR-142-3p FAM198B 1.13 0 0.43 0.03934 miRanda -0.15 0.00057 NA
86 hsa-miR-142-3p FAM47E 1.13 0 -2.23 0 miRanda -0.13 0.03655 NA
87 hsa-miR-142-3p FAP 1.13 0 3.06 0 miRanda -0.15 0.02218 NA
88 hsa-miR-142-3p FAT3 1.13 0 -0.03 0.93085 PITA; miRanda -0.19 0.0126 NA
89 hsa-miR-142-3p FBN1 1.13 0 0.64 0.01726 miRanda -0.26 1.0E-5 NA
90 hsa-miR-142-3p FBXO36 1.13 0 -0.54 0.00042 miRanda -0.13 4.0E-5 NA
91 hsa-miR-142-3p FGF9 1.13 0 -1.38 1.0E-5 miRanda -0.26 0.00011 NA
92 hsa-miR-142-3p FIGN 1.13 0 -0.5 0.14028 miRanda -0.14 0.04834 NA
93 hsa-miR-142-3p FKBP14 1.13 0 0.91 0 MirTarget -0.14 1.0E-5 NA
94 hsa-miR-142-3p FKBP7 1.13 0 0.25 0.15133 miRanda -0.18 0 NA
95 hsa-miR-142-3p FLNC 1.13 0 -1.72 1.0E-5 miRanda -0.46 0 NA
96 hsa-miR-142-3p FMN1 1.13 0 -1.27 0 miRanda -0.13 0.01991 NA
97 hsa-miR-142-3p FNBP1L 1.13 0 -0.48 6.0E-5 PITA; miRanda; miRNATAP -0.12 0 NA
98 hsa-miR-142-3p FXR1 1.13 0 0.25 0.00761 miRanda -0.1 0 NA
99 hsa-miR-142-3p FZD3 1.13 0 -0.41 0.03782 miRanda -0.12 0.00483 NA
100 hsa-miR-142-3p FZD7 1.13 0 -0.4 0.08915 miRanda -0.29 0 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p
101 hsa-miR-142-3p GABRR1 1.13 0 0.49 0.23053 miRanda -0.23 0.00995 NA
102 hsa-miR-142-3p GALNT5 1.13 0 -2.35 0 miRanda -0.34 2.0E-5 NA
103 hsa-miR-142-3p GHR 1.13 0 -1.23 0 MirTarget; PITA; miRanda; miRNATAP -0.3 0 NA
104 hsa-miR-142-3p GJA1 1.13 0 1.11 0 miRanda -0.26 0 NA
105 hsa-miR-142-3p GLI2 1.13 0 0.41 0.19124 miRanda -0.42 0 NA
106 hsa-miR-142-3p GNAS 1.13 0 -0.38 0 PITA; miRanda -0.1 0 NA
107 hsa-miR-142-3p GPC4 1.13 0 -0.89 0.00373 miRNAWalker2 validate -0.26 7.0E-5 NA
108 hsa-miR-142-3p GPC6 1.13 0 0.57 0.07279 miRanda -0.34 0 NA
109 hsa-miR-142-3p GPRC5A 1.13 0 -0.4 0.14329 miRanda -0.14 0.01704 NA
110 hsa-miR-142-3p GPRC5B 1.13 0 -1.38 0 miRanda -0.18 0.00083 NA
111 hsa-miR-142-3p GRIN3B 1.13 0 1.46 3.0E-5 miRanda -0.2 0.00684 NA
112 hsa-miR-142-3p GSTM4 1.13 0 -0.85 0.0001 miRanda -0.15 0.0019 NA
113 hsa-miR-142-3p GTF2A1 1.13 0 -0.27 0.18436 MirTarget; PITA; miRanda; miRNATAP -0.14 0.00141 NA
114 hsa-miR-142-3p HHIPL1 1.13 0 1.18 0 mirMAP -0.2 1.0E-5 NA
115 hsa-miR-142-3p HIF3A 1.13 0 -2.25 0 miRanda -0.18 0.03725 NA
116 hsa-miR-142-3p HIST1H2AE 1.13 0 1.28 0 miRanda -0.11 0.03452 NA
117 hsa-miR-142-3p HMCN1 1.13 0 -0.25 0.37847 miRanda -0.25 6.0E-5 NA
118 hsa-miR-142-3p HS3ST5 1.13 0 -0.97 0.02503 miRanda -0.24 0.012 NA
119 hsa-miR-142-3p ID4 1.13 0 -2.1 0 miRanda -0.2 8.0E-5 NA
120 hsa-miR-142-3p IER3 1.13 0 -0.42 0.02491 miRanda; miRNATAP -0.14 0.00065 NA
121 hsa-miR-142-3p IL6ST 1.13 0 -1.52 0 miRanda; miRNATAP -0.15 0.0243 NA
122 hsa-miR-142-3p INPP4B 1.13 0 0.05 0.82897 miRanda -0.11 0.03224 NA
123 hsa-miR-142-3p INPP5A 1.13 0 -0.63 0 MirTarget; PITA; miRanda; miRNATAP -0.17 0 NA
124 hsa-miR-142-3p IPMK 1.13 0 -0.39 0.12125 MirTarget; miRNATAP -0.11 0.03734 NA
125 hsa-miR-142-3p IQCA1 1.13 0 0.43 0.22908 miRanda -0.15 0.04673 NA
126 hsa-miR-142-3p IRX2 1.13 0 0.57 0.06913 miRanda -0.26 9.0E-5 NA
127 hsa-miR-142-3p ITGBL1 1.13 0 -0.33 0.33179 miRanda -0.3 5.0E-5 NA
128 hsa-miR-142-3p KDM5B 1.13 0 0.41 0.00064 miRanda -0.12 0 NA
129 hsa-miR-142-3p KIF5A 1.13 0 -0.74 0.0103 miRanda -0.15 0.01372 NA
130 hsa-miR-142-3p KLF9 1.13 0 -1.05 0 miRanda -0.16 1.0E-5 NA
131 hsa-miR-142-3p KLK3 1.13 0 -2.25 0 miRanda -0.51 0 NA
132 hsa-miR-142-3p KY 1.13 0 -2.71 0 miRanda -0.29 0.0014 NA
133 hsa-miR-142-3p LATS1 1.13 0 -0.19 0.29287 MirTarget -0.11 0.00307 NA
134 hsa-miR-142-3p LCA5 1.13 0 -0.91 0 miRanda -0.16 0.00011 NA
135 hsa-miR-142-3p LMO3 1.13 0 -2.75 0 miRanda; miRNATAP -0.27 0.00113 NA
136 hsa-miR-142-3p LNX1 1.13 0 -1.61 0 miRanda -0.1 0.01721 NA
137 hsa-miR-142-3p LONP2 1.13 0 -0.33 0.00072 miRanda -0.12 0 NA
138 hsa-miR-142-3p LPP 1.13 0 0.22 0.17089 miRTarBase; miRanda; miRNATAP -0.17 0 NA
139 hsa-miR-142-3p LRP1B 1.13 0 -2.5 0 MirTarget; miRanda; miRNATAP -0.38 1.0E-5 NA
140 hsa-miR-142-3p LRRC17 1.13 0 0.46 0.15853 miRanda; miRNATAP -0.38 0 NA
141 hsa-miR-142-3p LRRC32 1.13 0 0.2 0.25841 PITA; miRanda; miRNATAP -0.17 1.0E-5 NA
142 hsa-miR-142-3p LTBP4 1.13 0 -0.58 4.0E-5 miRanda -0.14 1.0E-5 NA
143 hsa-miR-142-3p LUZP2 1.13 0 -2.19 0 miRanda -0.38 1.0E-5 NA
144 hsa-miR-142-3p MAGI1 1.13 0 -1.66 0 miRanda -0.11 0.00082 NA
145 hsa-miR-142-3p MAMDC2 1.13 0 -2.32 0 miRanda -0.2 0.00536 NA
146 hsa-miR-142-3p MAN1A2 1.13 0 -0.37 0.00831 miRNAWalker2 validate -0.11 0.00038 NA
147 hsa-miR-142-3p MAP2 1.13 0 -0.65 0.02427 PITA; miRanda -0.26 4.0E-5 NA
148 hsa-miR-142-3p MCFD2 1.13 0 -0.36 1.0E-5 miRNAWalker2 validate; miRanda -0.1 0 NA
149 hsa-miR-142-3p ME1 1.13 0 -0.77 0.0007 PITA; miRanda -0.28 0 NA
150 hsa-miR-142-3p MEX3A 1.13 0 0.62 0.00355 miRanda -0.13 0.0034 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 ORGAN MORPHOGENESIS 38 841 3.843e-10 5.96e-07
2 APPENDAGE DEVELOPMENT 17 169 3.741e-10 5.96e-07
3 LIMB DEVELOPMENT 17 169 3.741e-10 5.96e-07
4 NEUROGENESIS 51 1402 6.451e-10 7.504e-07
5 NEURON DIFFERENTIATION 37 874 3.921e-09 3.649e-06
6 CELL DEVELOPMENT 49 1426 9.518e-09 6.48e-06
7 CARDIOVASCULAR SYSTEM DEVELOPMENT 34 788 1.114e-08 6.48e-06
8 CIRCULATORY SYSTEM DEVELOPMENT 34 788 1.114e-08 6.48e-06
9 TISSUE DEVELOPMENT 50 1518 2.564e-08 1.326e-05
10 NEURON PROJECTION MORPHOGENESIS 22 402 9.333e-08 3.948e-05
11 CELLULAR COMPONENT MORPHOGENESIS 35 900 8.787e-08 3.948e-05
12 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 36 957 1.284e-07 4.737e-05
13 HEAD DEVELOPMENT 30 709 1.323e-07 4.737e-05
14 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 7 33 3.615e-07 0.0001121
15 POSITIVE REGULATION OF OSSIFICATION 10 84 3.43e-07 0.0001121
16 CENTRAL NERVOUS SYSTEM DEVELOPMENT 33 872 3.929e-07 0.0001143
17 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 25 554 4.821e-07 0.0001304
18 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 50 1672 5.043e-07 0.0001304
19 EMBRYO DEVELOPMENT 33 894 6.853e-07 0.0001678
20 EMBRYONIC MORPHOGENESIS 24 539 1.044e-06 0.0002428
21 HEART DEVELOPMENT 22 466 1.147e-06 0.0002542
22 NEURON PROJECTION DEVELOPMENT 24 545 1.268e-06 0.0002681
23 GLAND MORPHOGENESIS 10 97 1.326e-06 0.0002683
24 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 11 122 1.503e-06 0.0002832
25 REGULATION OF CELL DIFFERENTIATION 45 1492 1.643e-06 0.0002832
26 TUBE DEVELOPMENT 24 552 1.584e-06 0.0002832
27 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 23 513 1.571e-06 0.0002832
28 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 60 2.186e-06 0.0003633
29 MUSCLE TISSUE DEVELOPMENT 16 275 2.504e-06 0.0004018
30 SKELETAL SYSTEM DEVELOPMENT 21 455 2.885e-06 0.0004437
31 REGULATION OF ACTIN FILAMENT BASED PROCESS 17 312 2.956e-06 0.0004437
32 REGULATION OF HEART CONTRACTION 14 221 4.028e-06 0.0005858
33 REGULATION OF DEVELOPMENTAL GROWTH 16 289 4.735e-06 0.0005955
34 FOREBRAIN DEVELOPMENT 18 357 4.48e-06 0.0005955
35 LOCOMOTION 36 1114 4.52e-06 0.0005955
36 VASCULATURE DEVELOPMENT 21 469 4.618e-06 0.0005955
37 REGULATION OF CARDIAC CONDUCTION 8 66 4.555e-06 0.0005955
38 EYE DEVELOPMENT 17 326 5.311e-06 0.0006504
39 NEURON DEVELOPMENT 26 687 7.221e-06 8e-04
40 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 18 368 6.806e-06 8e-04
41 EMBRYONIC ORGAN DEVELOPMENT 19 406 7.102e-06 8e-04
42 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 8 70 7.125e-06 8e-04
43 CARDIAC CHAMBER DEVELOPMENT 11 144 7.583e-06 0.0008206
44 REGULATION OF OSSIFICATION 12 178 1.057e-05 0.001118
45 REGULATION OF CELL DEVELOPMENT 29 836 1.115e-05 0.001153
46 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 27 750 1.181e-05 0.001194
47 RESPONSE TO KETONE 12 182 1.323e-05 0.00131
48 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 11 154 1.435e-05 0.001348
49 RESPONSE TO HORMONE 30 893 1.444e-05 0.001348
50 BIOLOGICAL ADHESION 33 1032 1.448e-05 0.001348
51 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 38 1275 1.529e-05 0.001368
52 REGULATION OF SYSTEM PROCESS 21 507 1.506e-05 0.001368
53 CELL PART MORPHOGENESIS 24 633 1.596e-05 0.00137
54 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 5 23 1.6e-05 0.00137
55 MUSCLE CELL DEVELOPMENT 10 128 1.619e-05 0.00137
56 REGULATION OF EPITHELIAL CELL PROLIFERATION 15 285 1.711e-05 0.001422
57 REGULATION OF NEURON DIFFERENTIATION 22 554 1.803e-05 0.001472
58 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 35 1142 1.92e-05 0.00154
59 MESENCHYME DEVELOPMENT 12 190 2.035e-05 0.001605
60 MAMMARY GLAND MORPHOGENESIS 6 40 2.111e-05 0.00161
61 MORPHOGENESIS OF AN EPITHELIUM 18 400 2.095e-05 0.00161
62 BLOOD VESSEL MORPHOGENESIS 17 364 2.224e-05 0.001669
63 MESENCHYMAL CELL DIFFERENTIATION 10 134 2.414e-05 0.001783
64 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 5 25 2.467e-05 0.001794
65 REGULATION OF BLOOD CIRCULATION 15 295 2.559e-05 0.001832
66 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 8 84 2.767e-05 0.001922
67 TELENCEPHALON DEVELOPMENT 13 228 2.728e-05 0.001922
68 CARDIAC SEPTUM DEVELOPMENT 8 85 3.017e-05 0.002064
69 TISSUE MORPHOGENESIS 21 533 3.145e-05 0.002121
70 SENSORY ORGAN DEVELOPMENT 20 493 3.234e-05 0.002149
71 CARDIAC MUSCLE TISSUE DEVELOPMENT 10 140 3.522e-05 0.002308
72 RESPONSE TO STEROID HORMONE 20 497 3.622e-05 0.002341
73 PATTERN SPECIFICATION PROCESS 18 418 3.735e-05 0.002381
74 NEURON PROJECTION GUIDANCE 12 205 4.3e-05 0.002704
75 CALCIUM MEDIATED SIGNALING 8 90 4.568e-05 0.002834
76 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 12 207 4.725e-05 0.002893
77 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 39 1395 4.854e-05 0.002933
78 RESPONSE TO ENDOGENOUS STIMULUS 40 1450 5.165e-05 0.003055
79 REGULATION OF CALCIUM ION TRANSPORT 12 209 5.187e-05 0.003055
80 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 8 92 5.352e-05 0.003113
81 EMBRYONIC ORGAN MORPHOGENESIS 14 279 5.487e-05 0.003152
82 DIGESTIVE SYSTEM DEVELOPMENT 10 148 5.655e-05 0.003205
83 MUSCLE STRUCTURE DEVELOPMENT 18 432 5.717e-05 0.003205
84 POSITIVE REGULATION OF CELL DIFFERENTIATION 27 823 5.914e-05 0.003276
85 RESPONSE TO ORGANIC CYCLIC COMPOUND 29 917 6.008e-05 0.003289
86 DIGESTIVE TRACT MORPHOGENESIS 6 48 6.129e-05 0.003316
87 POSITIVE REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 5 31 7.354e-05 0.003933
88 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 30 983 8.473e-05 0.00448
89 PROXIMAL DISTAL PATTERN FORMATION 5 32 8.614e-05 0.004503
90 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 26 801 9.663e-05 0.004996
91 NEURAL CREST CELL DIFFERENTIATION 7 75 0.0001005 0.005137
92 EPITHELIUM DEVELOPMENT 29 945 0.0001016 0.005139
93 CELL PROJECTION ORGANIZATION 28 902 0.0001109 0.005547
94 REGULATION OF BMP SIGNALING PATHWAY 7 77 0.0001188 0.00588
95 CELL CELL SIGNALING 25 767 0.0001237 0.006019
96 REGULATION OF MUSCLE SYSTEM PROCESS 11 195 0.0001242 0.006019
97 REGULATION OF CARDIAC MUSCLE CONTRACTION BY REGULATION OF THE RELEASE OF SEQUESTERED CALCIUM ION 4 19 0.0001358 0.006291
98 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 30 1008 0.0001319 0.006291
99 RESPIRATORY SYSTEM DEVELOPMENT 11 197 0.0001359 0.006291
100 REGULATION OF CELLULAR COMPONENT MOVEMENT 25 771 0.0001341 0.006291
101 ODONTOGENESIS 8 105 0.0001366 0.006291
102 REGULATION OF TRANSPORTER ACTIVITY 11 198 0.0001421 0.006481
103 MUSCLE CONTRACTION 12 233 0.0001459 0.006585
104 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 10 166 0.0001472 0.006585
105 CELLULAR RESPONSE TO HORMONE STIMULUS 20 552 0.0001516 0.006717
106 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 36 0.0001539 0.006754
107 EYE MORPHOGENESIS 9 136 0.0001554 0.00676
108 RESPONSE TO VITAMIN A 4 20 0.0001678 0.00723
109 HINDLIMB MORPHOGENESIS 5 37 0.0001758 0.007276
110 POSITIVE REGULATION OF CELL DEVELOPMENT 18 472 0.0001738 0.007276
111 MUSCLE CELL DIFFERENTIATION 12 237 0.000171 0.007276
112 CARDIAC CONDUCTION 7 82 0.0001767 0.007276
113 REGIONALIZATION 14 311 0.0001728 0.007276
114 CELL MOTILITY 26 835 0.000187 0.0075
115 LOCALIZATION OF CELL 26 835 0.000187 0.0075
116 SENSORY ORGAN MORPHOGENESIS 12 239 0.0001849 0.0075
117 REGULATION OF GLIAL CELL DIFFERENTIATION 6 59 0.0001972 0.007844
118 STRIATED MUSCLE CELL DIFFERENTIATION 10 173 0.0002061 0.008128
119 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 17 437 0.0002081 0.008137
120 REGULATION OF OSTEOBLAST DIFFERENTIATION 8 112 0.0002136 0.008284
121 HEART PROCESS 7 85 0.0002212 0.008505
122 CELLULAR RESPONSE TO ACID CHEMICAL 10 175 0.0002262 0.008558
123 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 10 175 0.0002262 0.008558
124 MUSCLE SYSTEM PROCESS 13 282 0.0002331 0.008747
125 SOMATIC STEM CELL DIVISION 4 22 0.0002477 0.009221
126 HEART MORPHOGENESIS 11 212 0.0002574 0.009506
127 MULTI MULTICELLULAR ORGANISM PROCESS 11 213 0.000268 0.00982
128 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 8 116 0.0002717 0.009878
129 REGULATION OF CATION CHANNEL ACTIVITY 7 88 0.0002743 0.009893
130 REGULATION OF MUSCLE CONTRACTION 9 147 0.0002787 0.009977
131 REGULATION OF RECEPTOR ACTIVITY 8 117 0.0002881 0.009993
132 POSITIVE REGULATION OF GENE EXPRESSION 43 1733 0.0002846 0.009993
133 SPECIFICATION OF SYMMETRY 8 117 0.0002881 0.009993
134 MAMMARY GLAND DEVELOPMENT 8 117 0.0002881 0.009993
135 OSSIFICATION 12 251 0.0002899 0.009993
NumGOOverlapSizeP ValueAdj. P Value
1 CALCIUM ION BINDING 29 697 3.079e-07 0.000286
2 ACTIN BINDING 18 393 1.656e-05 0.005312
3 PROTEIN HOMODIMERIZATION ACTIVITY 26 722 1.716e-05 0.005312
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEINACEOUS EXTRACELLULAR MATRIX 23 356 2.114e-09 1.234e-06
2 EXTRACELLULAR MATRIX 24 426 1.367e-08 3.991e-06
3 CONTRACTILE FIBER 15 211 4.244e-07 8.262e-05
4 INTERCALATED DISC 7 51 7.856e-06 0.0009176
5 EXTRACELLULAR SPACE 41 1376 6.817e-06 0.0009176
6 CELL JUNCTION 35 1151 2.261e-05 0.002201
7 ACTOMYOSIN 7 62 2.917e-05 0.002434
8 CELL CELL CONTACT ZONE 7 64 3.596e-05 0.002625
9 GOLGI LUMEN 8 94 6.244e-05 0.004052
10 SARCOLEMMA 9 125 8.143e-05 0.004755
11 COSTAMERE 4 19 0.0001358 0.007209
12 NEURON PART 35 1265 0.0001497 0.007285
13 ACTIN FILAMENT BUNDLE 6 57 0.0001627 0.007309
14 ACTIN CYTOSKELETON 17 444 0.0002505 0.008607
15 SYNAPSE 24 754 0.0002405 0.008607
16 NEURON PROJECTION 28 942 0.0002273 0.008607
17 SYNAPSE PART 21 610 0.0002092 0.008607

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04350_TGF.beta_signaling_pathway 8 85 3.017e-05 0.00543
2 hsa04390_Hippo_signaling_pathway 9 154 0.0003929 0.0306
3 hsa04510_Focal_adhesion 10 200 0.0006506 0.0306
4 hsa04530_Tight_junction 8 133 0.00068 0.0306
5 hsa04810_Regulation_of_actin_cytoskeleton 10 214 0.001091 0.03929
6 hsa04310_Wnt_signaling_pathway 8 151 0.001545 0.04574
7 hsa04970_Salivary_secretion 6 89 0.001779 0.04574
8 hsa04971_Gastric_acid_secretion 5 74 0.004226 0.09508
9 hsa04010_MAPK_signaling_pathway 10 268 0.005533 0.1107
10 hsa04270_Vascular_smooth_muscle_contraction 6 116 0.006598 0.1188
11 hsa00562_Inositol_phosphate_metabolism 4 57 0.009038 0.1479
12 hsa04912_GnRH_signaling_pathway 5 101 0.01523 0.1959
13 hsa04916_Melanogenesis 5 101 0.01523 0.1959
14 hsa04972_Pancreatic_secretion 5 101 0.01523 0.1959
15 hsa03320_PPAR_signaling_pathway 4 70 0.01817 0.218
16 hsa04260_Cardiac_muscle_contraction 4 77 0.02483 0.2793
17 hsa04151_PI3K_AKT_signaling_pathway 10 351 0.03084 0.3266
18 hsa04360_Axon_guidance 5 130 0.03959 0.3665
19 hsa04540_Gap_junction 4 90 0.04066 0.3665
20 hsa04964_Proximal_tubule_bicarbonate_reclamation 2 23 0.04259 0.3665
21 hsa04020_Calcium_signaling_pathway 6 177 0.04276 0.3665
22 hsa04340_Hedgehog_signaling_pathway 3 56 0.04645 0.38
23 hsa00030_Pentose_phosphate_pathway 2 27 0.05693 0.427
24 hsa00052_Galactose_metabolism 2 27 0.05693 0.427
25 hsa04920_Adipocytokine_signaling_pathway 3 68 0.07425 0.5346
26 hsa04730_Long.term_depression 3 70 0.07947 0.5476
27 hsa04976_Bile_secretion 3 71 0.08213 0.5476
28 hsa04670_Leukocyte_transendothelial_migration 4 117 0.08808 0.5662
29 hsa00565_Ether_lipid_metabolism 2 36 0.09405 0.5838
30 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.1018 0.611
31 hsa04974_Protein_digestion_and_absorption 3 81 0.1108 0.6433
32 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.1217 0.6683
33 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.1313 0.6683
34 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.1313 0.6683
35 hsa04514_Cell_adhesion_molecules_.CAMs. 4 136 0.1323 0.6683
36 hsa04910_Insulin_signaling_pathway 4 138 0.1374 0.6683
37 hsa00510_N.Glycan_biosynthesis 2 49 0.156 0.721
38 hsa04666_Fc_gamma_R.mediated_phagocytosis 3 95 0.1562 0.721
39 hsa00010_Glycolysis_._Gluconeogenesis 2 65 0.2393 1
40 hsa04014_Ras_signaling_pathway 5 236 0.2518 1
41 hsa04115_p53_signaling_pathway 2 69 0.2606 1
42 hsa04722_Neurotrophin_signaling_pathway 3 127 0.2749 1
43 hsa04520_Adherens_junction 2 73 0.2819 1
44 hsa00564_Glycerophospholipid_metabolism 2 80 0.319 1
45 hsa04512_ECM.receptor_interaction 2 85 0.3452 1
46 hsa04012_ErbB_signaling_pathway 2 87 0.3556 1
47 hsa04630_Jak.STAT_signaling_pathway 3 155 0.3844 1
48 hsa04062_Chemokine_signaling_pathway 3 189 0.5114 1
49 hsa04110_Cell_cycle 2 128 0.5506 1
50 hsa04380_Osteoclast_differentiation 2 128 0.5506 1
51 hsa04144_Endocytosis 3 203 0.5596 1
52 hsa00230_Purine_metabolism 2 162 0.6782 1
53 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.6974 1

Quest ID: d084111abb8835c1122a5e7b93734eec