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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-3p ALDH7A1 -0.57 0 -0.75 0 mirMAP -0.14 0.0475 NA
2 hsa-let-7a-3p ANKRD52 -0.57 0 1.46 0 mirMAP -0.13 0.02173 NA
3 hsa-let-7a-3p AP3B1 -0.57 0 0.63 0 mirMAP -0.17 0 NA
4 hsa-let-7a-3p ARSB -0.57 0 0 0.99867 mirMAP -0.22 0.00013 NA
5 hsa-let-7a-3p ASTN2 -0.57 0 0.17 0.20898 mirMAP -0.2 0.00126 NA
6 hsa-let-7a-3p ATP5E -0.57 0 0.38 0.00141 mirMAP -0.26 0 NA
7 hsa-let-7a-3p ATP6V1C1 -0.57 0 0.88 0 mirMAP -0.28 0 NA
8 hsa-let-7a-3p ATP6V1H -0.57 0 0.48 0 MirTarget -0.15 0.00047 NA
9 hsa-let-7a-3p BRF2 -0.57 0 0.45 0 MirTarget -0.16 0.00019 NA
10 hsa-let-7a-3p BTF3 -0.57 0 0.14 0.09744 miRNAWalker2 validate -0.28 0 NA
11 hsa-let-7a-3p C1QBP -0.57 0 -0.2 0.04809 MirTarget -0.18 8.0E-5 NA
12 hsa-let-7a-3p C2orf49 -0.57 0 0.2 0.006 mirMAP -0.15 1.0E-5 NA
13 hsa-let-7a-3p CCDC15 -0.57 0 0.85 0 MirTarget -0.13 0.03172 NA
14 hsa-let-7a-3p CCDC34 -0.57 0 1.55 0 MirTarget -0.34 0 NA
15 hsa-let-7a-3p CCNA2 -0.57 0 3.37 0 MirTarget -0.51 4.0E-5 NA
16 hsa-let-7a-3p CDHR3 -0.57 0 0.83 1.0E-5 mirMAP -0.29 0.00054 NA
17 hsa-let-7a-3p CDK6 -0.57 0 -0.31 0.22057 miRNATAP -0.34 0.00261 NA
18 hsa-let-7a-3p CDS2 -0.57 0 -0.19 0.0262 mirMAP -0.11 0.00613 NA
19 hsa-let-7a-3p CHRAC1 -0.57 0 0.33 0.00039 MirTarget -0.12 0.00331 NA
20 hsa-let-7a-3p CISD2 -0.57 0 -0.16 0.06189 mirMAP -0.11 0.00455 NA
21 hsa-let-7a-3p CLDN12 -0.57 0 -0.37 0.00035 MirTarget; miRNATAP -0.17 0.00028 NA
22 hsa-let-7a-3p CS -0.57 0 0.63 0 miRNAWalker2 validate -0.12 0.00343 NA
23 hsa-let-7a-3p CTU2 -0.57 0 0.11 0.23765 MirTarget -0.17 9.0E-5 NA
24 hsa-let-7a-3p DEPDC1 -0.57 0 3.92 0 mirMAP -0.53 0.00019 NA
25 hsa-let-7a-3p DERL1 -0.57 0 0.12 0.20253 MirTarget -0.17 5.0E-5 NA
26 hsa-let-7a-3p E2F8 -0.57 0 3.82 0 MirTarget -0.43 0.00339 NA
27 hsa-let-7a-3p EIF1 -0.57 0 0 0.97475 MirTarget -0.2 0 NA
28 hsa-let-7a-3p EIF1AD -0.57 0 0.26 1.0E-5 MirTarget -0.11 2.0E-5 NA
29 hsa-let-7a-3p EIF4A1 -0.57 0 -0.08 0.43947 MirTarget -0.16 0.00057 NA
30 hsa-let-7a-3p ELL2 -0.57 0 -0.77 0 mirMAP -0.16 0.01742 NA
31 hsa-let-7a-3p ELMOD2 -0.57 0 -0.03 0.7088 mirMAP -0.11 0.00387 NA
32 hsa-let-7a-3p ERAP1 -0.57 0 -0.06 0.66413 MirTarget -0.2 0.00064 NA
33 hsa-let-7a-3p EXO1 -0.57 0 4.16 0 MirTarget -0.61 2.0E-5 NA
34 hsa-let-7a-3p FAM117A -0.57 0 -0.43 0.0012 miRNATAP -0.17 0.00436 NA
35 hsa-let-7a-3p FAM19A4 -0.57 0 0.54 0.19076 MirTarget -0.37 0.04385 NA
36 hsa-let-7a-3p FAM96A -0.57 0 -0.43 1.0E-5 MirTarget -0.11 0.00972 NA
37 hsa-let-7a-3p FANCF -0.57 0 0.51 0 mirMAP -0.11 0.00167 NA
38 hsa-let-7a-3p FBXL18 -0.57 0 2.18 0 mirMAP -0.2 0.00845 NA
39 hsa-let-7a-3p FBXO32 -0.57 0 1.5 0 mirMAP -0.39 0.00015 NA
40 hsa-let-7a-3p FKBP1A -0.57 0 0.49 0 miRNATAP -0.12 0.00151 NA
41 hsa-let-7a-3p FSTL5 -0.57 0 1.27 0.01386 MirTarget -0.82 0.00042 NA
42 hsa-let-7a-3p GABRA2 -0.57 0 0.51 0.19599 mirMAP -0.48 0.00712 NA
43 hsa-let-7a-3p GAS2 -0.57 0 -0.59 0.00349 MirTarget; mirMAP; miRNATAP -0.29 0.00142 NA
44 hsa-let-7a-3p GDPD1 -0.57 0 1.18 0 MirTarget -0.24 0.0212 NA
45 hsa-let-7a-3p GPR158 -0.57 0 2.24 0 miRNATAP -0.76 0.00018 NA
46 hsa-let-7a-3p GTPBP10 -0.57 0 -0.21 0.01214 mirMAP -0.14 0.00014 NA
47 hsa-let-7a-3p HLF -0.57 0 -1.56 0 mirMAP -0.3 0.02086 NA
48 hsa-let-7a-3p HMGB2 -0.57 0 1.2 0 MirTarget -0.18 0.00569 NA
49 hsa-let-7a-3p HMGCR -0.57 0 -0.03 0.86086 miRNATAP -0.24 0.00028 NA
50 hsa-let-7a-3p HNRNPA1 -0.57 0 0.66 0 miRNATAP -0.2 0 NA
51 hsa-let-7a-3p HSD17B11 -0.57 0 -0.51 0.00011 MirTarget -0.16 0.00749 NA
52 hsa-let-7a-3p HSDL1 -0.57 0 0.62 0 mirMAP -0.19 4.0E-5 NA
53 hsa-let-7a-3p HSP90AB1 -0.57 0 0.89 0 miRNATAP -0.24 0 NA
54 hsa-let-7a-3p ICK -0.57 0 0.39 0.01043 MirTarget; miRNATAP -0.17 0.01423 NA
55 hsa-let-7a-3p IGFBP1 -0.57 0 -2.37 0 MirTarget -0.59 0.00049 NA
56 hsa-let-7a-3p KIAA1429 -0.57 0 0.53 0 MirTarget; miRNATAP -0.17 1.0E-5 NA
57 hsa-let-7a-3p KIF11 -0.57 0 2.12 0 MirTarget; miRNATAP -0.2 0.02787 NA
58 hsa-let-7a-3p LEF1 -0.57 0 2.66 0 miRNATAP -0.64 4.0E-5 NA
59 hsa-let-7a-3p LIN7A -0.57 0 -0.54 0.00089 mirMAP -0.3 5.0E-5 NA
60 hsa-let-7a-3p LRRC28 -0.57 0 -0.47 0.00026 mirMAP -0.14 0.01479 NA
61 hsa-let-7a-3p LSM11 -0.57 0 0.76 0 mirMAP -0.18 0.00017 NA
62 hsa-let-7a-3p LYPLAL1 -0.57 0 0.33 0.00426 MirTarget -0.22 3.0E-5 NA
63 hsa-let-7a-3p MAFG -0.57 0 1.2 0 MirTarget; miRNATAP -0.27 2.0E-5 NA
64 hsa-let-7a-3p MAP2 -0.57 0 1.05 6.0E-5 MirTarget; miRNATAP -0.3 0.01296 NA
65 hsa-let-7a-3p MEAF6 -0.57 0 -0.06 0.55761 MirTarget -0.16 0.00017 NA
66 hsa-let-7a-3p MGEA5 -0.57 0 -0.17 0.01346 MirTarget -0.12 0.00018 NA
67 hsa-let-7a-3p MID1 -0.57 0 0.45 0.00323 mirMAP -0.2 0.00357 NA
68 hsa-let-7a-3p MIF4GD -0.57 0 0.52 0 MirTarget -0.18 0.0001 NA
69 hsa-let-7a-3p MTBP -0.57 0 2.14 0 MirTarget -0.19 0.04499 NA
70 hsa-let-7a-3p NAA38 -0.57 0 0.47 0 mirMAP -0.22 0 NA
71 hsa-let-7a-3p NEDD4 -0.57 0 -0.21 0.20967 mirMAP -0.29 0.00016 NA
72 hsa-let-7a-3p NGDN -0.57 0 0.27 8.0E-5 MirTarget -0.14 1.0E-5 NA
73 hsa-let-7a-3p NOLC1 -0.57 0 -0.07 0.38299 MirTarget; miRNATAP -0.13 0.00013 NA
74 hsa-let-7a-3p NUDT16 -0.57 0 -0.31 0.00173 mirMAP -0.2 0 NA
75 hsa-let-7a-3p OTUD6B -0.57 0 0.72 0 MirTarget -0.14 0.00723 NA
76 hsa-let-7a-3p PBX2 -0.57 0 0.5 0 mirMAP -0.12 0.00773 NA
77 hsa-let-7a-3p PDAP1 -0.57 0 0.37 0 MirTarget; miRNATAP -0.2 0 NA
78 hsa-let-7a-3p PDCL3 -0.57 0 0.59 0 MirTarget -0.11 0.00336 NA
79 hsa-let-7a-3p PHYHIPL -0.57 0 0.88 0.00299 MirTarget; miRNATAP -0.47 0.00041 NA
80 hsa-let-7a-3p POLR2K -0.57 0 0.85 0 MirTarget -0.25 0 NA
81 hsa-let-7a-3p PPP1CC -0.57 0 0.5 0 mirMAP -0.14 3.0E-5 NA
82 hsa-let-7a-3p PRLR -0.57 0 -0.35 0.07612 mirMAP -0.19 0.03775 NA
83 hsa-let-7a-3p RAB2A -0.57 0 0.19 0.02675 miRNATAP -0.13 0.00101 NA
84 hsa-let-7a-3p RAB4A -0.57 0 0.23 0.01748 mirMAP -0.14 0.00165 NA
85 hsa-let-7a-3p RABGGTB -0.57 0 0.27 0.0019 MirTarget -0.23 0 NA
86 hsa-let-7a-3p RB1CC1 -0.57 0 0.3 0.01377 miRNATAP -0.17 0.00203 NA
87 hsa-let-7a-3p RBBP7 -0.57 0 0.5 0 miRNATAP -0.11 0.00037 NA
88 hsa-let-7a-3p RBM3 -0.57 0 1.01 0 MirTarget -0.14 0.0061 NA
89 hsa-let-7a-3p RFC3 -0.57 0 0.96 0 MirTarget -0.17 0.00334 NA
90 hsa-let-7a-3p RIOK2 -0.57 0 0.08 0.21349 MirTarget; mirMAP -0.15 0 NA
91 hsa-let-7a-3p RNASEH1 -0.57 0 0.51 0 mirMAP -0.18 0 NA
92 hsa-let-7a-3p RNF149 -0.57 0 -0.15 0.07181 MirTarget -0.1 0.00815 NA
93 hsa-let-7a-3p RRP15 -0.57 0 0.55 0 MirTarget; miRNATAP -0.12 0.00268 NA
94 hsa-let-7a-3p RTKN2 -0.57 0 2.58 0 mirMAP -0.35 0.01331 NA
95 hsa-let-7a-3p SDC2 -0.57 0 -0.03 0.81477 MirTarget -0.13 0.02792 NA
96 hsa-let-7a-3p SEPT9 -0.57 0 0.49 0 MirTarget; miRNATAP -0.1 0.00728 NA
97 hsa-let-7a-3p SIX4 -0.57 0 2.62 0 mirMAP -0.51 0.00104 NA
98 hsa-let-7a-3p SLC1A2 -0.57 0 -2.05 1.0E-5 miRNATAP -0.62 0.00272 NA
99 hsa-let-7a-3p SLC44A5 -0.57 0 0.94 0.06247 mirMAP -0.71 0.00185 NA
100 hsa-let-7a-3p SLC7A11 -0.57 0 3.47 0 mirMAP -0.79 1.0E-5 NA
101 hsa-let-7a-3p SQLE -0.57 0 1.81 0 miRNATAP -0.49 0 NA
102 hsa-let-7a-3p STEAP2 -0.57 0 -0.39 0.27701 mirMAP -0.62 0.00012 NA
103 hsa-let-7a-3p STXBP6 -0.57 0 1.62 0 mirMAP -0.48 0 NA
104 hsa-let-7a-3p SYF2 -0.57 0 0.12 0.09292 MirTarget -0.13 5.0E-5 NA
105 hsa-let-7a-3p TBCA -0.57 0 0.15 0.12434 mirMAP -0.28 0 NA
106 hsa-let-7a-3p TIGD7 -0.57 0 0.92 0 MirTarget -0.12 0.03181 NA
107 hsa-let-7a-3p TMEM117 -0.57 0 0.42 0.00165 MirTarget -0.17 0.00394 NA
108 hsa-let-7a-3p TMEM68 -0.57 0 0.47 0 MirTarget -0.14 0.00112 NA
109 hsa-let-7a-3p TSFM -0.57 0 -0.23 0.00439 MirTarget -0.19 0 NA
110 hsa-let-7a-3p UBE2B -0.57 0 -0.1 0.19938 mirMAP; miRNATAP -0.14 0.00017 NA
111 hsa-let-7a-3p UBE2F -0.57 0 -0.01 0.86834 miRNATAP -0.11 0.00074 NA
112 hsa-let-7a-3p UBFD1 -0.57 0 0.11 0.18136 MirTarget -0.14 0.00017 NA
113 hsa-let-7a-3p UQCRB -0.57 0 0.53 6.0E-5 mirMAP -0.33 0 NA
114 hsa-let-7a-3p WDR43 -0.57 0 -0.06 0.46873 miRNATAP -0.11 0.0013 NA
115 hsa-let-7a-3p YEATS4 -0.57 0 0.18 0.04365 MirTarget -0.12 0.00193 NA
116 hsa-let-7a-3p ZSWIM1 -0.57 0 0.67 0 MirTarget -0.1 0.00756 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 RNA BINDING 29 1598 2.267e-08 2.106e-05
2 POLY A RNA BINDING 23 1170 2.148e-07 9.978e-05
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa00190_Oxidative_phosphorylation 4 132 0.007347 0.5269
2 hsa03430_Mismatch_repair 2 23 0.007792 0.5269
3 hsa04120_Ubiquitin_mediated_proteolysis 4 139 0.008781 0.5269
4 hsa03030_DNA_replication 2 36 0.01848 0.6652
5 hsa04142_Lysosome 3 121 0.03342 1
6 hsa03008_Ribosome_biogenesis_in_eukaryotes 2 81 0.08041 1
7 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.09083 1
8 hsa03040_Spliceosome 2 128 0.1701 1
9 hsa04110_Cell_cycle 2 128 0.1701 1
10 hsa03013_RNA_transport 2 152 0.2205 1
11 hsa04390_Hippo_signaling_pathway 2 154 0.2248 1
12 hsa04145_Phagosome 2 156 0.229 1
13 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.2547 1
14 hsa04144_Endocytosis 2 203 0.3297 1
15 hsa04151_PI3K_AKT_signaling_pathway 3 351 0.3331 1

Quest ID: d635801584fb478d47fb655588c63419