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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-495-3p ABCG1 0 0 0 0 MirTarget -0.16 0 NA
2 hsa-miR-495-3p ABHD2 0 0 0 0 mirMAP -0.12 0.00017 NA
3 hsa-miR-495-3p ADSS 0 0 0 0 mirMAP -0.11 0 NA
4 hsa-miR-495-3p AGPAT3 0 0 0 0 mirMAP -0.11 0 NA
5 hsa-miR-495-3p ARNT2 0 0 0 0 mirMAP -0.32 0 NA
6 hsa-miR-495-3p BAIAP2L1 0 0 0 0 mirMAP -0.17 0 NA
7 hsa-miR-495-3p BCAS1 0 0 0 0 mirMAP -0.3 9.0E-5 NA
8 hsa-miR-495-3p BCL9 0 0 0 0 MirTarget -0.16 0 NA
9 hsa-miR-495-3p BRI3BP 0 0 0 0 mirMAP -0.21 0 NA
10 hsa-miR-495-3p BRIP1 0 0 0 0 mirMAP -0.29 0 NA
11 hsa-miR-495-3p BUB1 0 0 0 0 MirTarget -0.42 0 NA
12 hsa-miR-495-3p C10orf35 0 0 0 0 mirMAP -0.19 0 NA
13 hsa-miR-495-3p C8orf33 0 0 0 0 mirMAP -0.12 0 NA
14 hsa-miR-495-3p CACNA1D 0 0 0 0 MirTarget -0.16 0.00332 NA
15 hsa-miR-495-3p CBX3 0 0 0 0 MirTarget -0.15 0 NA
16 hsa-miR-495-3p CBX4 0 0 0 0 MirTarget -0.31 0 NA
17 hsa-miR-495-3p CCDC117 0 0 0 0 mirMAP -0.15 0 NA
18 hsa-miR-495-3p CCDC125 0 0 0 0 mirMAP -0.12 0 NA
19 hsa-miR-495-3p CCND1 0 0 0 0 MirTarget -0.27 0 NA
20 hsa-miR-495-3p CDK16 0 0 0 0 MirTarget -0.1 0 NA
21 hsa-miR-495-3p CDK5R1 0 0 0 0 mirMAP -0.18 0 NA
22 hsa-miR-495-3p CDS1 0 0 0 0 mirMAP -0.18 0 NA
23 hsa-miR-495-3p CENPP 0 0 0 0 mirMAP -0.12 5.0E-5 NA
24 hsa-miR-495-3p CHEK1 0 0 0 0 MirTarget -0.16 0 NA
25 hsa-miR-495-3p CHMP5 0 0 0 0 mirMAP -0.12 0 NA
26 hsa-miR-10a-5p CHRNA5 0 0 0 0 miRNAWalker2 validate -0.35 0 NA
27 hsa-miR-495-3p CNTNAP2 0 0 0 0 mirMAP -0.2 0.02309 NA
28 hsa-miR-495-3p CSTF3 0 0 0 0 MirTarget -0.13 0 NA
29 hsa-miR-495-3p CYCS 0 0 0 0 mirMAP -0.1 0 NA
30 hsa-miR-495-3p CYP4F3 0 0 0 0 mirMAP -0.25 0.00043 NA
31 hsa-miR-495-3p DCAF10 0 0 0 0 MirTarget; mirMAP -0.12 1.0E-5 NA
32 hsa-miR-495-3p DCAF7 0 0 0 0 mirMAP -0.11 0 NA
33 hsa-miR-495-3p DDA1 0 0 0 0 mirMAP -0.11 0 NA
34 hsa-miR-495-3p DERL1 0 0 0 0 mirMAP -0.1 0 NA
35 hsa-miR-495-3p DKC1 0 0 0 0 mirMAP -0.12 0 NA
36 hsa-miR-495-3p DNAJC14 0 0 0 0 MirTarget -0.1 0 NA
37 hsa-miR-495-3p DRP2 0 0 0 0 mirMAP -0.15 0.00012 NA
38 hsa-miR-495-3p DTL 0 0 0 0 MirTarget -0.41 0 NA
39 hsa-miR-495-3p DTX3L 0 0 0 0 mirMAP -0.11 0 NA
40 hsa-miR-495-3p E2F5 0 0 0 0 MirTarget -0.24 0 NA
41 hsa-miR-495-3p EARS2 0 0 0 0 mirMAP -0.13 0 NA
42 hsa-miR-495-3p EIF3H 0 0 0 0 mirMAP -0.14 0 NA
43 hsa-miR-495-3p ELAVL1 0 0 0 0 MirTarget -0.12 0 NA
44 hsa-miR-495-3p ELAVL2 0 0 0 0 mirMAP -0.24 1.0E-5 NA
45 hsa-miR-495-3p EPHA10 0 0 0 0 mirMAP -0.38 0 NA
46 hsa-miR-495-3p ESM1 0 0 0 0 MirTarget -0.35 0 NA
47 hsa-miR-495-3p FAM122B 0 0 0 0 MirTarget; mirMAP -0.14 0 NA
48 hsa-miR-495-3p FAM135B 0 0 0 0 MirTarget -0.27 6.0E-5 NA
49 hsa-miR-495-3p FBXO45 0 0 0 0 mirMAP -0.14 0 NA
50 hsa-miR-495-3p FOXK2 0 0 0 0 mirMAP -0.14 0 NA
51 hsa-miR-495-3p FSD1L 0 0 0 0 mirMAP -0.14 0 NA
52 hsa-miR-495-3p GDAP1 0 0 0 0 MirTarget -0.16 4.0E-5 NA
53 hsa-miR-495-3p GINS4 0 0 0 0 mirMAP -0.25 0 NA
54 hsa-miR-495-3p GNG4 0 0 0 0 mirMAP -0.14 0.03094 NA
55 hsa-miR-495-3p GOLPH3L 0 0 0 0 MirTarget -0.13 0 NA
56 hsa-miR-495-3p GPATCH2 0 0 0 0 mirMAP -0.15 0 NA
57 hsa-miR-495-3p GPR137C 0 0 0 0 mirMAP -0.1 0.00046 NA
58 hsa-miR-495-3p GPR37L1 0 0 0 0 mirMAP -0.26 0 NA
59 hsa-miR-495-3p GPRC5A 0 0 0 0 MirTarget -0.29 0 NA
60 hsa-miR-495-3p H1F0 0 0 0 0 mirMAP -0.13 0 NA
61 hsa-miR-495-3p HELLS 0 0 0 0 mirMAP -0.25 0 NA
62 hsa-miR-495-3p HJURP 0 0 0 0 MirTarget -0.46 0 NA
63 hsa-miR-495-3p HMGB3 0 0 0 0 mirMAP -0.29 0 NA
64 hsa-miR-495-3p HN1L 0 0 0 0 mirMAP -0.18 0 NA
65 hsa-miR-495-3p HNRNPA2B1 0 0 0 0 mirMAP -0.12 0 NA
66 hsa-miR-495-3p HNRNPU 0 0 0 0 mirMAP -0.11 0 NA
67 hsa-miR-495-3p HTR1D 0 0 0 0 mirMAP -0.24 3.0E-5 NA
68 hsa-miR-495-3p IGF1R 0 0 0 0 mirMAP -0.13 0.00143 NA
69 hsa-miR-495-3p INTS7 0 0 0 0 mirMAP -0.19 0 NA
70 hsa-miR-495-3p KIAA1257 0 0 0 0 MirTarget -0.25 0 NA
71 hsa-miR-495-3p KPNA2 0 0 0 0 MirTarget -0.27 0 NA
72 hsa-miR-495-3p L2HGDH 0 0 0 0 mirMAP -0.11 0 NA
73 hsa-miR-495-3p LAGE3 0 0 0 0 MirTarget -0.23 0 NA
74 hsa-miR-495-3p LDLRAD3 0 0 0 0 MirTarget -0.13 0.00015 NA
75 hsa-miR-495-3p LETM1 0 0 0 0 mirMAP -0.17 0 NA
76 hsa-miR-495-3p LRPAP1 0 0 0 0 mirMAP -0.11 0 NA
77 hsa-miR-495-3p MAPKAPK2 0 0 0 0 mirMAP -0.14 0 NA
78 hsa-miR-495-3p MARCKSL1 0 0 0 0 mirMAP -0.21 0 NA
79 hsa-miR-495-3p MBOAT2 0 0 0 0 mirMAP -0.14 0 NA
80 hsa-miR-495-3p MED12L 0 0 0 0 MirTarget -0.12 0.01292 NA
81 hsa-miR-495-3p MFSD10 0 0 0 0 MirTarget -0.17 0 NA
82 hsa-miR-495-3p MGAT4A 0 0 0 0 mirMAP -0.11 0.00012 NA
83 hsa-miR-495-3p MKI67 0 0 0 0 mirMAP -0.36 0 NA
84 hsa-miR-495-3p MKRN3 0 0 0 0 MirTarget -0.18 0.04013 NA
85 hsa-miR-495-3p MOCOS 0 0 0 0 mirMAP -0.11 0.00032 NA
86 hsa-miR-495-3p MORF4L2 0 0 0 0 MirTarget -0.14 0 NA
87 hsa-miR-495-3p MRS2 0 0 0 0 mirMAP -0.1 0 NA
88 hsa-miR-495-3p MSI2 0 0 0 0 mirMAP -0.2 0 NA
89 hsa-miR-495-3p MTHFD2 0 0 0 0 mirMAP -0.17 0 NA
90 hsa-miR-495-3p MYCBP 0 0 0 0 MirTarget -0.14 0 NA
91 hsa-miR-495-3p MYEF2 0 0 0 0 MirTarget -0.17 0 NA
92 hsa-miR-495-3p NAT14 0 0 0 0 MirTarget -0.2 0 NA
93 hsa-miR-495-3p NCLN 0 0 0 0 mirMAP -0.12 0 NA
94 hsa-miR-495-3p NDUFA5 0 0 0 0 mirMAP -0.1 0 NA
95 hsa-miR-495-3p NEBL 0 0 0 0 mirMAP -0.15 0 NA
96 hsa-miR-495-3p NECAP1 0 0 0 0 MirTarget; mirMAP -0.11 0 NA
97 hsa-miR-495-3p NELL1 0 0 0 0 MirTarget -0.28 0.00059 NA
98 hsa-miR-495-3p NIPA1 0 0 0 0 mirMAP -0.13 0 NA
99 hsa-miR-495-3p NOX5 0 0 0 0 mirMAP -0.16 0.00431 NA
100 hsa-miR-495-3p NUP62 0 0 0 0 MirTarget -0.12 0 NA
101 hsa-miR-495-3p NUP62CL 0 0 0 0 MirTarget -0.16 0.00045 NA
102 hsa-miR-495-3p OAS2 0 0 0 0 mirMAP -0.12 0.00213 NA
103 hsa-miR-495-3p OCLN 0 0 0 0 mirMAP -0.16 0 NA
104 hsa-miR-495-3p ORAI2 0 0 0 0 mirMAP -0.11 0 NA
105 hsa-miR-495-3p OTUD7B 0 0 0 0 MirTarget -0.12 0 NA
106 hsa-miR-495-3p PAQR5 0 0 0 0 mirMAP -0.19 0 NA
107 hsa-miR-495-3p PARN 0 0 0 0 mirMAP -0.12 0 NA
108 hsa-miR-495-3p PBX1 0 0 0 0 mirMAP -0.16 0 NA
109 hsa-miR-495-3p PCBD2 0 0 0 0 mirMAP -0.11 0 NA
110 hsa-miR-495-3p PDCD10 0 0 0 0 MirTarget -0.11 0 NA
111 hsa-miR-495-3p PDIK1L 0 0 0 0 mirMAP -0.12 0 NA
112 hsa-miR-495-3p PFKFB4 0 0 0 0 mirMAP -0.16 0 NA
113 hsa-miR-495-3p PIP5K1A 0 0 0 0 mirMAP -0.13 0 NA
114 hsa-miR-495-3p PLEKHF2 0 0 0 0 MirTarget -0.18 0 NA
115 hsa-miR-495-3p PLEKHH3 0 0 0 0 MirTarget -0.11 3.0E-5 NA
116 hsa-miR-495-3p PPM1H 0 0 0 0 mirMAP -0.16 0 NA
117 hsa-miR-495-3p PPP4C 0 0 0 0 MirTarget -0.17 0 NA
118 hsa-miR-495-3p PRC1 0 0 0 0 mirMAP -0.35 0 NA
119 hsa-miR-495-3p PRLR 0 0 0 0 mirMAP -0.17 0.0001 NA
120 hsa-miR-495-3p PROM2 0 0 0 0 MirTarget -0.17 1.0E-5 NA
121 hsa-miR-495-3p PRR13 0 0 0 0 mirMAP -0.13 0 NA
122 hsa-miR-495-3p PRR7 0 0 0 0 MirTarget -0.29 0 NA
123 hsa-miR-495-3p PRRG4 0 0 0 0 MirTarget -0.15 0 NA
124 hsa-miR-495-3p RAB11FIP1 0 0 0 0 mirMAP -0.11 0.00213 NA
125 hsa-miR-495-3p RAB3D 0 0 0 0 mirMAP -0.15 0 NA
126 hsa-miR-495-3p RAB3IP 0 0 0 0 mirMAP -0.17 0 NA
127 hsa-miR-495-3p RAN 0 0 0 0 MirTarget -0.11 0 NA
128 hsa-miR-495-3p RANBP1 0 0 0 0 MirTarget -0.11 0 NA
129 hsa-miR-495-3p RBM47 0 0 0 0 MirTarget -0.15 0 NA
130 hsa-miR-495-3p RECQL5 0 0 0 0 mirMAP -0.11 0 NA
131 hsa-miR-495-3p RET 0 0 0 0 MirTarget -0.42 0 NA
132 hsa-miR-495-3p RMI1 0 0 0 0 MirTarget -0.19 0 NA
133 hsa-miR-495-3p RNF43 0 0 0 0 mirMAP -0.11 0.02372 NA
134 hsa-miR-495-3p RPRD1A 0 0 0 0 MirTarget; mirMAP -0.11 0 NA
135 hsa-miR-495-3p RTKN2 0 0 0 0 mirMAP -0.17 0 NA
136 hsa-miR-495-3p SAR1B 0 0 0 0 MirTarget -0.11 0 NA
137 hsa-miR-495-3p SCUBE3 0 0 0 0 mirMAP -0.16 0.00839 NA
138 hsa-miR-495-3p SDC4 0 0 0 0 MirTarget -0.13 0 NA
139 hsa-miR-495-3p SERP1 0 0 0 0 mirMAP -0.11 0 NA
140 hsa-miR-495-3p SFPQ 0 0 0 0 MirTarget -0.1 0 NA
141 hsa-miR-495-3p SHANK2 0 0 0 0 mirMAP -0.12 0.00039 NA
142 hsa-miR-495-3p SHROOM2 0 0 0 0 mirMAP -0.16 0 NA
143 hsa-miR-495-3p SIX4 0 0 0 0 mirMAP -0.24 0 NA
144 hsa-miR-495-3p SLC1A2 0 0 0 0 mirMAP -0.23 3.0E-5 NA
145 hsa-miR-495-3p SLC1A4 0 0 0 0 mirMAP -0.16 0 NA
146 hsa-miR-495-3p SLC22A5 0 0 0 0 MirTarget -0.14 0 NA
147 hsa-miR-495-3p SLC25A17 0 0 0 0 mirMAP -0.11 0 NA
148 hsa-miR-495-3p SLC30A8 0 0 0 0 mirMAP -0.46 7.0E-5 NA
149 hsa-miR-495-3p SLC35E3 0 0 0 0 mirMAP -0.12 0 NA
150 hsa-miR-495-3p SLC39A11 0 0 0 0 mirMAP -0.17 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 5 124 0.005955 0.3097
2 Cellular_senescence_hsa04218 5 160 0.01667 0.3392
3 p53_signaling_pathway_hsa04115 3 68 0.02516 0.3392
4 AMPK_signaling_pathway_hsa04152 4 121 0.02609 0.3392
5 Oocyte_meiosis_hsa04114 3 124 0.1078 0.9252
6 Adherens_junction_hsa04520 2 72 0.1433 0.9252
7 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.1512 0.9252
8 Jak_STAT_signaling_pathway_hsa04630 3 162 0.1897 0.9252
9 Endocytosis_hsa04144 4 244 0.1903 0.9252
10 Tight_junction_hsa04530 3 170 0.2086 0.9252
11 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.2276 0.9252
12 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.2331 0.9252
13 FoxO_signaling_pathway_hsa04068 2 132 0.3456 0.9252
14 Apelin_signaling_pathway_hsa04371 2 137 0.3623 0.9252
15 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.392 0.9252
16 Hippo_signaling_pathway_hsa04390 2 154 0.4178 0.9252
17 Necroptosis_hsa04217 2 164 0.4493 0.9252
18 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.4761 0.9252
19 Calcium_signaling_pathway_hsa04020 2 182 0.5036 0.9252
20 MAPK_signaling_pathway_hsa04010 3 295 0.5155 0.9252
21 cAMP_signaling_pathway_hsa04024 2 198 0.5488 0.9252
22 Focal_adhesion_hsa04510 2 199 0.5515 0.9252
23 Ras_signaling_pathway_hsa04014 2 232 0.6351 1

Quest ID: dcd8b1a57848410aea18e3233b0b965e