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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-34a-5p ADAM22 0.13 0.13326 -1.22 0 MirTarget; miRNATAP -0.33 5.0E-5 NA
2 hsa-miR-34a-5p ALX4 0.13 0.13326 -3.22 0 mirMAP -0.47 2.0E-5 NA
3 hsa-miR-34a-5p ANK2 0.13 0.13326 -2.51 0 MirTarget; miRNATAP -0.32 0 NA
4 hsa-miR-34a-5p ASTN1 0.13 0.13326 -2.96 0 MirTarget -0.54 0 NA
5 hsa-miR-34a-5p CACHD1 0.13 0.13326 -2.57 0 MirTarget -0.38 0 NA
6 hsa-miR-34a-5p CAPN6 0.13 0.13326 -3.62 0 miRNATAP -0.8 0 NA
7 hsa-miR-34a-5p DCX 0.13 0.13326 -2.75 0 MirTarget; miRNATAP -0.68 0 NA
8 hsa-miR-34a-5p EDAR 0.13 0.13326 -2.79 0 miRNATAP -0.46 4.0E-5 NA
9 hsa-miR-34a-5p FAT4 0.13 0.13326 -2.33 0 MirTarget -0.35 0 NA
10 hsa-miR-34a-5p GFRA1 0.13 0.13326 -0.69 0.0647 miRNATAP -0.66 1.0E-5 NA
11 hsa-miR-34a-5p KCNA1 0.13 0.13326 -2.93 0 miRNATAP -0.59 0 NA
12 hsa-miR-34a-5p KCNQ4 0.13 0.13326 -2.01 0 mirMAP -0.31 0.00177 NA
13 hsa-miR-34a-5p KIT 0.13 0.13326 -3.56 0 MirTarget -0.44 0 NA
14 hsa-miR-34a-5p MLC1 0.13 0.13326 -0.01 0.98183 mirMAP -0.42 6.0E-5 NA
15 hsa-miR-34a-5p MYRIP 0.13 0.13326 -2.17 0 miRNATAP -0.53 0 NA
16 hsa-miR-34a-5p NGFR 0.13 0.13326 -2.5 0 mirMAP -0.49 0 NA
17 hsa-miR-34a-5p NOS1AP 0.13 0.13326 -0.68 0.00068 miRNATAP -0.34 2.0E-5 NA
18 hsa-miR-34a-5p PAX5 0.13 0.13326 0.19 0.53615 mirMAP -0.37 0.00242 NA
19 hsa-miR-34a-5p PPP1R16B 0.13 0.13326 -2.18 0 MirTarget; miRNATAP -0.36 0 NA
20 hsa-miR-34a-5p PROX1 0.13 0.13326 -3.3 0 miRNATAP -0.36 0.0005 NA
21 hsa-miR-34a-5p RELN 0.13 0.13326 -4.67 0 miRNATAP -0.7 0 NA
22 hsa-miR-34a-5p SCN1A 0.13 0.13326 0.74 0.01506 miRNATAP -0.33 0.00687 NA
23 hsa-miR-34a-5p SCN2B 0.13 0.13326 -3.86 0 MirTarget; miRNATAP -0.32 0.00467 NA
24 hsa-miR-34a-5p SOX6 0.13 0.13326 -2.37 0 miRNATAP -0.43 1.0E-5 NA
25 hsa-miR-34a-5p TGFBR3 0.13 0.13326 -3.32 0 miRNATAP -0.34 9.0E-5 NA
26 hsa-miR-34a-5p TSHZ2 0.13 0.13326 -3.17 0 miRNATAP -0.35 3.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 PALLIUM DEVELOPMENT 6 153 3.685e-08 0.0001715
2 REGULATION OF MEMBRANE POTENTIAL 7 343 2.04e-07 0.0004746
3 TELENCEPHALON DEVELOPMENT 6 228 3.91e-07 0.0006064
4 MUSCLE STRUCTURE DEVELOPMENT 7 432 9.637e-07 0.0007474
5 CELL DEVELOPMENT 11 1426 6.618e-07 0.0007474
6 REGULATION OF TRANSMEMBRANE TRANSPORT 7 426 8.777e-07 0.0007474
7 MUSCLE ORGAN DEVELOPMENT 6 277 1.22e-06 0.0008107
8 HIPPOCAMPUS DEVELOPMENT 4 73 2.298e-06 0.001336
9 FOREBRAIN DEVELOPMENT 6 357 5.28e-06 0.002457
10 NEUROGENESIS 10 1402 5.211e-06 0.002457
11 ACTION POTENTIAL 4 94 6.319e-06 0.002602
12 REGULATION OF TRANSPORT 11 1804 6.71e-06 0.002602
13 REGULATION OF ION TRANSPORT 7 592 7.742e-06 0.002686
14 LIMBIC SYSTEM DEVELOPMENT 4 100 8.083e-06 0.002686
15 CEREBRAL CORTEX DEVELOPMENT 4 105 9.81e-06 0.002853
16 CENTRAL NERVOUS SYSTEM DEVELOPMENT 8 872 9.802e-06 0.002853
17 TISSUE DEVELOPMENT 10 1518 1.058e-05 0.002895
18 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 3 39 1.728e-05 0.004467
19 MULTICELLULAR ORGANISMAL SIGNALING 4 123 1.834e-05 0.004491
20 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 9 1275 1.961e-05 0.004562
21 MUSCLE TISSUE DEVELOPMENT 5 275 2.461e-05 0.005452
22 BEHAVIOR 6 516 4.249e-05 0.008987
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 CATION CHANNEL COMPLEX 5 167 2.182e-06 0.001274
2 APICAL PART OF CELL 6 361 5.628e-06 0.001643
3 NEURON PART 9 1265 1.841e-05 0.002688
4 NEURON PROJECTION 8 942 1.72e-05 0.002688
5 T TUBULE 3 45 2.669e-05 0.003117
6 CELL PROJECTION 10 1786 4.384e-05 0.003658
7 PLASMA MEMBRANE PROTEIN COMPLEX 6 510 3.981e-05 0.003658
8 TRANSPORTER COMPLEX 5 321 5.148e-05 0.003758
9 VOLTAGE GATED SODIUM CHANNEL COMPLEX 2 14 0.0001465 0.008554
10 PLASMA MEMBRANE REGION 7 929 0.000138 0.008554

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

Quest ID: dcdfc6a0091e166bac8629f2d673696d