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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-107 ACVR1 0.24 0.01708 -0.44 1.0E-5 miRanda -0.2 5.0E-5 NA
2 hsa-miR-148a-3p ACVR1 -0.75 0 -0.44 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.0001 NA
3 hsa-miR-362-3p ACVR1 0.81 0 -0.44 1.0E-5 miRanda -0.16 1.0E-5 NA
4 hsa-let-7d-5p ACVR1C 0.05 0.70258 -2.2 0 MirTarget; miRNATAP -0.47 0 NA
5 hsa-let-7e-5p ACVR1C 0.04 0.81107 -2.2 0 MirTarget; miRNATAP -0.47 0 NA
6 hsa-let-7i-5p ACVR1C -0.14 0.15414 -2.2 0 MirTarget; miRNATAP -0.36 0.00521 NA
7 hsa-miR-181a-5p ACVR1C 0.25 0.05519 -2.2 0 miRNATAP -0.67 0 NA
8 hsa-miR-181b-5p ACVR1C 0.49 0.00105 -2.2 0 miRNATAP -0.67 0 NA
9 hsa-miR-181c-5p ACVR1C -0.01 0.96913 -2.2 0 miRNATAP -0.46 0 NA
10 hsa-miR-200b-3p ACVR1C -1.29 0.00027 -2.2 0 TargetScan -0.18 0 NA
11 hsa-miR-330-3p ACVR1C -0.33 0.03161 -2.2 0 MirTarget -0.2 0.01814 NA
12 hsa-miR-331-5p ACVR1C 0.21 0.12077 -2.2 0 miRNATAP -0.35 0.00018 NA
13 hsa-miR-409-3p ACVR1C -0.5 0.05268 -2.2 0 MirTarget -0.1 0.0381 NA
14 hsa-miR-429 ACVR1C -1.4 7.0E-5 -2.2 0 PITA; miRanda; miRNATAP -0.17 0 NA
15 hsa-miR-98-5p ACVR1C -0.05 0.71591 -2.2 0 MirTarget -0.41 2.0E-5 NA
16 hsa-miR-185-5p ACVR2A 0.48 0 -0.55 0 miRNATAP -0.17 2.0E-5 NA
17 hsa-miR-188-5p ACVR2A 1.12 0 -0.55 0 PITA -0.13 0 NA
18 hsa-miR-21-5p ACVR2A 1.51 0 -0.55 0 miRNATAP -0.17 0 NA
19 hsa-let-7b-3p ACVR2B -1.22 0 -0.24 0.05503 MirTarget -0.17 3.0E-5 NA
20 hsa-miR-140-3p ACVR2B 0.55 0 -0.24 0.05503 miRNAWalker2 validate; PITA; miRNATAP -0.23 0.00167 NA
21 hsa-miR-32-3p BMP2 0.22 0.20722 -0.18 0.35911 mirMAP -0.14 0.01775 NA
22 hsa-miR-142-3p BMP4 -1.42 0 0.76 0.00257 PITA; miRanda -0.21 0.00115 NA
23 hsa-miR-590-3p BMP4 -0.47 2.0E-5 0.76 0.00257 miRanda -0.27 0.01577 NA
24 hsa-miR-130b-3p BMP6 0.69 0.00011 -1.04 0 MirTarget -0.26 0 NA
25 hsa-miR-301a-3p BMP6 0.84 0 -1.04 0 MirTarget -0.14 0.01206 NA
26 hsa-miR-362-3p BMP6 0.81 0 -1.04 0 miRanda -0.3 4.0E-5 NA
27 hsa-miR-454-3p BMP6 0.67 0 -1.04 0 MirTarget -0.22 0.00157 NA
28 hsa-miR-130b-5p BMP7 0.17 0.33761 0.83 0.04887 mirMAP -0.32 0.00583 NA
29 hsa-miR-1976 BMP7 -0.43 0.00325 0.83 0.04887 MirTarget -0.45 0.00115 NA
30 hsa-miR-22-3p BMP7 -0.63 0 0.83 0.04887 miRNAWalker2 validate; miRTarBase -0.87 1.0E-5 NA
31 hsa-miR-30a-5p BMP7 -0.63 0.00011 0.83 0.04887 mirMAP; miRNATAP -0.35 0.00579 NA
32 hsa-miR-30e-5p BMP7 -0.63 0 0.83 0.04887 mirMAP -0.58 0.00444 NA
33 hsa-miR-34a-5p BMP7 1.04 0 0.83 0.04887 miRNAWalker2 validate -0.45 0.00162 NA
34 hsa-miR-616-5p BMP7 0.15 0.40284 0.83 0.04887 mirMAP -0.33 0.0036 NA
35 hsa-miR-140-5p BMP8A -0.22 0.01407 1.39 0 miRanda -0.29 0.01813 NA
36 hsa-miR-146b-5p BMP8A 0.42 0.04574 1.39 0 miRanda -0.12 0.02024 NA
37 hsa-miR-194-3p BMP8A -0.77 3.0E-5 1.39 0 MirTarget -0.35 0 NA
38 hsa-miR-30b-3p BMP8A -0.44 0.00095 1.39 0 MirTarget -0.25 0.00222 NA
39 hsa-miR-30e-3p BMP8A -1.21 0 1.39 0 MirTarget -0.32 0.00032 NA
40 hsa-miR-455-5p BMP8A -0.27 0.05813 1.39 0 MirTarget; miRanda -0.22 0.00398 NA
41 hsa-miR-107 BMP8B 0.24 0.01708 0.28 0.41783 mirMAP -0.33 0.0496 NA
42 hsa-miR-33a-5p BMP8B -0.77 1.0E-5 0.28 0.41783 mirMAP -0.2 0.03788 NA
43 hsa-miR-618 BMP8B 0.14 0.51715 0.28 0.41783 mirMAP -0.24 0.00328 NA
44 hsa-miR-140-5p BMPR1A -0.22 0.01407 0.07 0.48504 miRanda -0.15 0.00409 NA
45 hsa-miR-130b-3p BMPR1B 0.69 0.00011 -3.31 0 miRNATAP -0.34 0.00049 NA
46 hsa-miR-140-3p BMPR1B 0.55 0 -3.31 0 MirTarget -1.09 0 NA
47 hsa-miR-362-3p BMPR1B 0.81 0 -3.31 0 MirTarget; miRanda -0.65 0 NA
48 hsa-miR-374a-5p BMPR1B 0.02 0.86978 -3.31 0 MirTarget -0.96 0 NA
49 hsa-miR-374b-5p BMPR1B -0.31 0.00301 -3.31 0 MirTarget -0.45 0.00882 NA
50 hsa-miR-421 BMPR1B 0.94 0 -3.31 0 miRanda -0.25 0.01483 NA
51 hsa-miR-106b-5p BMPR2 0.65 0 -0.74 0 MirTarget; miRNATAP -0.22 0 NA
52 hsa-miR-130b-3p BMPR2 0.69 0.00011 -0.74 0 MirTarget; miRNATAP -0.12 2.0E-5 NA
53 hsa-miR-148b-3p BMPR2 0.27 0.00185 -0.74 0 mirMAP -0.27 1.0E-5 NA
54 hsa-miR-17-5p BMPR2 0.7 2.0E-5 -0.74 0 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.26 0 NA
55 hsa-miR-185-5p BMPR2 0.48 0 -0.74 0 MirTarget -0.25 0 NA
56 hsa-miR-19a-3p BMPR2 1.02 0 -0.74 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.17 0 NA
57 hsa-miR-19b-3p BMPR2 0.6 0.00017 -0.74 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.21 0 NA
58 hsa-miR-20a-5p BMPR2 0.85 0 -0.74 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.24 0 NA
59 hsa-miR-21-5p BMPR2 1.51 0 -0.74 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.28 0 NA
60 hsa-miR-25-3p BMPR2 0.63 0 -0.74 0 miRNATAP -0.17 0.00117 NA
61 hsa-miR-29a-5p BMPR2 -0.11 0.34962 -0.74 0 mirMAP -0.15 0.00063 NA
62 hsa-miR-301a-3p BMPR2 0.84 0 -0.74 0 MirTarget; miRNATAP -0.11 0.00019 NA
63 hsa-miR-30d-5p BMPR2 0.72 0 -0.74 0 mirMAP -0.19 0 NA
64 hsa-miR-362-3p BMPR2 0.81 0 -0.74 0 MirTarget; PITA; miRanda; miRNATAP -0.18 0 NA
65 hsa-miR-455-5p BMPR2 -0.27 0.05813 -0.74 0 PITA -0.13 0.00044 NA
66 hsa-miR-532-5p BMPR2 1.03 0 -0.74 0 PITA -0.29 0 NA
67 hsa-miR-590-5p BMPR2 -0.1 0.31003 -0.74 0 MirTarget; PITA; miRNATAP -0.19 0.0002 NA
68 hsa-miR-618 BMPR2 0.14 0.51715 -0.74 0 PITA; mirMAP -0.1 5.0E-5 NA
69 hsa-miR-671-5p BMPR2 0.84 0 -0.74 0 miRNATAP -0.11 0.00171 NA
70 hsa-miR-769-5p BMPR2 0.22 0.03334 -0.74 0 miRNATAP -0.15 0.003 NA
71 hsa-miR-877-5p BMPR2 1.36 0 -0.74 0 MirTarget -0.15 0 NA
72 hsa-miR-92a-3p BMPR2 0.21 0.13429 -0.74 0 miRNAWalker2 validate; miRNATAP -0.24 0 NA
73 hsa-miR-93-3p BMPR2 0.4 0.00131 -0.74 0 miRNAWalker2 validate -0.19 0 NA
74 hsa-miR-93-5p BMPR2 1.4 0 -0.74 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.27 0 NA
75 hsa-miR-107 CDKN2B 0.24 0.01708 1.37 0 PITA -0.22 0.01132 NA
76 hsa-miR-126-5p CDKN2B -0.43 7.0E-5 1.37 0 mirMAP -0.33 5.0E-5 NA
77 hsa-miR-144-3p CDKN2B -2.98 0 1.37 0 MirTarget -0.17 0 NA
78 hsa-miR-382-5p CDKN2B -0.72 0.00849 1.37 0 mirMAP -0.1 0.00159 NA
79 hsa-miR-450b-5p CDKN2B -1.34 0 1.37 0 mirMAP -0.18 0.00085 NA
80 hsa-miR-451a CDKN2B -2.1 0 1.37 0 MirTarget -0.16 0 NA
81 hsa-miR-486-5p CDKN2B -1.78 0 1.37 0 miRanda -0.19 0 NA
82 hsa-let-7a-2-3p CHRD -1.19 0 -0.03 0.86098 MirTarget -0.12 0.00806 NA
83 hsa-let-7a-5p CHRD -0.33 0.00046 -0.03 0.86098 MirTarget; TargetScan; miRNATAP -0.31 0.0027 NA
84 hsa-let-7b-5p CHRD -0.96 0 -0.03 0.86098 MirTarget; miRNATAP -0.19 0.00276 NA
85 hsa-let-7d-5p CHRD 0.05 0.70258 -0.03 0.86098 MirTarget; miRNATAP -0.27 0.00016 NA
86 hsa-let-7e-5p CHRD 0.04 0.81107 -0.03 0.86098 MirTarget; miRNATAP -0.19 0.00298 NA
87 hsa-let-7f-5p CHRD -0.23 0.10329 -0.03 0.86098 MirTarget; miRNATAP -0.14 0.03702 NA
88 hsa-let-7g-5p CHRD -0.46 2.0E-5 -0.03 0.86098 MirTarget; miRNATAP -0.18 0.03708 NA
89 hsa-let-7i-5p CHRD -0.14 0.15414 -0.03 0.86098 MirTarget; miRNATAP -0.37 0.00013 NA
90 hsa-miR-98-5p CHRD -0.05 0.71591 -0.03 0.86098 MirTarget -0.27 0.00013 NA
91 hsa-miR-324-3p CREBBP 0.26 0.05061 -0.2 0.01387 miRNAWalker2 validate -0.12 3.0E-5 NA
92 hsa-miR-330-5p CREBBP 0.44 0.00533 -0.2 0.01387 miRanda -0.11 1.0E-5 NA
93 hsa-miR-769-5p CREBBP 0.22 0.03334 -0.2 0.01387 miRNAWalker2 validate -0.13 0.00077 NA
94 hsa-miR-27a-3p CUL1 -0.37 0.00876 -0.12 0.10228 miRNAWalker2 validate -0.1 4.0E-5 NA
95 hsa-miR-146b-5p DCN 0.42 0.04574 -4.16 0 miRanda -0.23 0.03337 NA
96 hsa-miR-186-5p DCN -0.06 0.53529 -4.16 0 mirMAP -0.85 0.00024 NA
97 hsa-miR-374b-3p DCN -0.14 0.30532 -4.16 0 MirTarget -0.44 0.00821 NA
98 hsa-miR-421 DCN 0.94 0 -4.16 0 miRanda -0.71 0 NA
99 hsa-miR-501-5p DCN 1.15 0 -4.16 0 mirMAP -0.3 0.01375 NA
100 hsa-miR-23b-3p E2F4 -0.53 0 0.53 0 miRNAWalker2 validate -0.13 0.00024 NA
101 hsa-let-7a-2-3p E2F5 -1.19 0 0.73 0.0004 MirTarget -0.24 0 NA
102 hsa-let-7a-5p E2F5 -0.33 0.00046 0.73 0.0004 MirTarget; TargetScan; miRNATAP -0.39 0.00034 NA
103 hsa-let-7b-5p E2F5 -0.96 0 0.73 0.0004 miRNAWalker2 validate; MirTarget; miRNATAP -0.22 0.0012 NA
104 hsa-let-7c-5p E2F5 -1.71 0 0.73 0.0004 MirTarget -0.23 1.0E-5 NA
105 hsa-let-7g-3p E2F5 -1.14 0 0.73 0.0004 MirTarget; miRNATAP -0.31 4.0E-5 NA
106 hsa-let-7g-5p E2F5 -0.46 2.0E-5 0.73 0.0004 MirTarget; miRNATAP -0.28 0.00248 NA
107 hsa-miR-1-3p E2F5 -0.66 0.01025 0.73 0.0004 MirTarget -0.11 0.00713 NA
108 hsa-miR-192-5p E2F5 -0.5 0.00345 0.73 0.0004 miRNAWalker2 validate -0.17 0.00489 NA
109 hsa-miR-3653-3p E2F5 -1.78 0 0.73 0.0004 MirTarget -0.16 0.0037 NA
110 hsa-miR-378a-3p E2F5 -1.19 0 0.73 0.0004 miRNAWalker2 validate -0.19 0.00021 NA
111 hsa-miR-491-5p E2F5 -0.37 0.0154 0.73 0.0004 miRanda -0.14 0.04254 NA
112 hsa-miR-22-3p EP300 -0.63 0 -0.2 0.07049 MirTarget; miRNATAP -0.1 0.04632 NA
113 hsa-miR-30d-3p EP300 -0.12 0.32955 -0.2 0.07049 MirTarget; miRNATAP -0.11 0.01494 NA
114 hsa-miR-339-5p EP300 0.28 0.03557 -0.2 0.07049 miRanda -0.16 0.0001 NA
115 hsa-miR-342-3p EP300 -0.32 0.04498 -0.2 0.07049 MirTarget; PITA; miRanda; miRNATAP -0.11 0.00085 NA
116 hsa-miR-361-3p EP300 0.28 0.00549 -0.2 0.07049 PITA -0.11 0.03791 NA
117 hsa-miR-320a FST 0.33 0.02214 -0.6 0.05579 PITA; miRanda -0.36 0.00079 NA
118 hsa-miR-320b FST 0.09 0.60798 -0.6 0.05579 PITA; miRanda -0.26 0.00293 NA
119 hsa-miR-425-5p FST 0.59 2.0E-5 -0.6 0.05579 MirTarget -0.22 0.0442 NA
120 hsa-miR-769-5p FST 0.22 0.03334 -0.6 0.05579 MirTarget; miRNATAP -0.49 0.00094 NA
121 hsa-miR-148a-3p GDF6 -0.75 0 -2.1 0 miRNATAP -0.33 0.00152 NA
122 hsa-miR-324-5p GDF6 0.37 0.00592 -2.1 0 miRanda -0.33 0.00405 NA
123 hsa-miR-532-3p GDF6 0.3 0.01463 -2.1 0 PITA; miRNATAP -0.56 1.0E-5 NA
124 hsa-miR-589-3p GDF6 1.17 0 -2.1 0 MirTarget -0.26 0.00226 NA
125 hsa-miR-616-5p GDF6 0.15 0.40284 -2.1 0 mirMAP -0.22 0.01171 NA
126 hsa-miR-197-3p GDF7 -0.25 0.03622 -1.71 0 miRNAWalker2 validate -0.65 0 NA
127 hsa-miR-224-3p GDF7 1.41 0 -1.71 0 mirMAP -0.33 0 NA
128 hsa-miR-502-5p GDF7 0.89 0 -1.71 0 mirMAP -0.29 0.00098 NA
129 hsa-miR-16-2-3p ID1 -0.03 0.80516 -2.25 0 MirTarget -0.19 0.02901 NA
130 hsa-miR-192-5p ID1 -0.5 0.00345 -2.25 0 miRNAWalker2 validate -0.15 0.02978 NA
131 hsa-miR-103a-3p ID2 0.77 0 -1.61 0 miRNAWalker2 validate; miRTarBase -0.31 1.0E-5 NA
132 hsa-miR-362-3p ID2 0.81 0 -1.61 0 miRanda; mirMAP -0.14 0.0163 NA
133 hsa-miR-3127-5p ID3 0.84 0 -0.64 3.0E-5 MirTarget -0.15 0.00133 NA
134 hsa-miR-148a-5p ID4 -0.77 0 -1.27 0 MirTarget -0.58 0 NA
135 hsa-miR-186-5p ID4 -0.06 0.53529 -1.27 0 miRNAWalker2 validate; mirMAP -0.33 0.01731 NA
136 hsa-miR-192-5p ID4 -0.5 0.00345 -1.27 0 miRNAWalker2 validate -0.51 0 NA
137 hsa-miR-324-3p ID4 0.26 0.05061 -1.27 0 miRNAWalker2 validate; PITA -0.37 0.00024 NA
138 hsa-miR-340-5p ID4 -0 0.9685 -1.27 0 miRNAWalker2 validate -0.22 0.04893 NA
139 hsa-miR-345-5p ID4 -0.71 0 -1.27 0 MirTarget -0.23 0.00759 NA
140 hsa-miR-362-3p ID4 0.81 0 -1.27 0 miRanda -0.29 0.00245 NA
141 hsa-miR-421 ID4 0.94 0 -1.27 0 miRanda -0.27 0.00039 NA
142 hsa-miR-532-3p ID4 0.3 0.01463 -1.27 0 PITA -0.57 0 NA
143 hsa-miR-589-3p ID4 1.17 0 -1.27 0 MirTarget -0.28 0.00015 NA
144 hsa-miR-590-5p ID4 -0.1 0.31003 -1.27 0 miRanda -0.5 0.00012 NA
145 hsa-miR-148b-3p INHBA 0.27 0.00185 -1.24 0 miRNAWalker2 validate -0.48 0.00159 NA
146 hsa-miR-30d-5p INHBA 0.72 0 -1.24 0 mirMAP -0.48 0 NA
147 hsa-miR-421 INHBA 0.94 0 -1.24 0 miRanda -0.16 0.0311 NA
148 hsa-miR-34a-5p INHBB 1.04 0 -0.72 0.00027 miRNATAP -0.28 3.0E-5 NA
149 hsa-miR-125a-3p INHBC -0.84 4.0E-5 -2.18 0 MirTarget; miRanda -0.38 0 NA
150 hsa-miR-224-3p LTBP1 1.41 0 -1.33 0 MirTarget -0.11 0.01636 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 37 190 6.304e-58 2.933e-54
2 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 33 207 4.427e-48 1.03e-44
3 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 22 60 1.415e-40 2.194e-37
4 RESPONSE TO BMP 24 94 7.111e-40 6.618e-37
5 CELLULAR RESPONSE TO BMP STIMULUS 24 94 7.111e-40 6.618e-37
6 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 39 689 1.668e-39 1.294e-36
7 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 24 100 3.828e-39 2.545e-36
8 RESPONSE TO GROWTH FACTOR 35 475 5.425e-39 3.156e-36
9 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 20 48 3.019e-38 1.561e-35
10 SMAD PROTEIN SIGNAL TRANSDUCTION 20 56 1.391e-36 6.474e-34
11 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 47 1784 7.691e-34 3.253e-31
12 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 38 1008 1.05e-31 4.071e-29
13 REGULATION OF OSSIFICATION 23 178 9.007e-31 3.224e-28
14 RESPONSE TO ENDOGENOUS STIMULUS 41 1450 1.095e-29 3.64e-27
15 POSITIVE REGULATION OF GENE EXPRESSION 42 1733 7.133e-28 2.213e-25
16 REGULATION OF OSTEOBLAST DIFFERENTIATION 19 112 8.856e-28 2.575e-25
17 ORGAN MORPHOGENESIS 33 841 1.419e-27 3.883e-25
18 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 41 1672 2.963e-27 7.257e-25
19 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 18 95 2.901e-27 7.257e-25
20 TISSUE DEVELOPMENT 39 1518 2.117e-26 4.925e-24
21 POSITIVE REGULATION OF OSSIFICATION 17 84 2.669e-26 5.913e-24
22 REGULATION OF PROTEIN MODIFICATION PROCESS 40 1710 1.146e-25 2.424e-23
23 REGULATION OF PHOSPHORUS METABOLIC PROCESS 39 1618 2.255e-25 4.562e-23
24 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 33 1004 4.077e-25 7.904e-23
25 ACTIVIN RECEPTOR SIGNALING PATHWAY 12 22 5.384e-25 1.002e-22
26 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 40 1805 8.861e-25 1.586e-22
27 TUBE DEVELOPMENT 27 552 1.017e-24 1.752e-22
28 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 34 1142 1.439e-24 2.392e-22
29 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 40 1848 2.153e-24 3.454e-22
30 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 36 1395 4.314e-24 6.692e-22
31 SKELETAL SYSTEM DEVELOPMENT 25 455 4.692e-24 7.042e-22
32 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 18 144 8.488e-24 1.234e-21
33 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 13 38 1.216e-23 1.714e-21
34 EPITHELIUM DEVELOPMENT 31 945 2.053e-23 2.81e-21
35 REGULATION OF CELL DIFFERENTIATION 36 1492 4.25e-23 5.494e-21
36 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 36 1492 4.25e-23 5.494e-21
37 POSITIVE REGULATION OF RESPONSE TO STIMULUS 39 1929 1.428e-22 1.796e-20
38 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 32 1135 3.085e-22 3.777e-20
39 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 1.257e-21 1.499e-19
40 CONNECTIVE TISSUE DEVELOPMENT 18 194 2.162e-21 2.515e-19
41 PROTEIN PHOSPHORYLATION 29 944 5.44e-21 6.174e-19
42 GROWTH 22 410 6.965e-21 7.661e-19
43 UROGENITAL SYSTEM DEVELOPMENT 20 299 7.079e-21 7.661e-19
44 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 13 60 1.097e-20 1.16e-18
45 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 29 983 1.658e-20 1.714e-18
46 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 9 13 2.475e-20 2.504e-18
47 CARTILAGE DEVELOPMENT 16 147 3.333e-20 3.3e-18
48 POSITIVE REGULATION OF CELL DIFFERENTIATION 27 823 3.497e-20 3.39e-18
49 REGULATION OF CELL DEATH 33 1472 6.326e-20 6.008e-18
50 REGULATION OF CELL PROLIFERATION 33 1496 1.039e-19 9.665e-18
51 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 14 99 2.019e-19 1.807e-17
52 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 14 99 2.019e-19 1.807e-17
53 POSITIVE REGULATION OF CELL COMMUNICATION 33 1532 2.149e-19 1.887e-17
54 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 13 75 2.586e-19 2.228e-17
55 EMBRYO DEVELOPMENT 27 894 2.921e-19 2.428e-17
56 CELL DEVELOPMENT 32 1426 2.922e-19 2.428e-17
57 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 14 102 3.135e-19 2.559e-17
58 REGULATION OF CELL DEVELOPMENT 26 836 7.976e-19 6.399e-17
59 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 28 1036 9.564e-19 7.417e-17
60 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 28 1036 9.564e-19 7.417e-17
61 NEGATIVE REGULATION OF CELL COMMUNICATION 29 1192 3.157e-18 2.408e-16
62 MESONEPHROS DEVELOPMENT 13 90 3.23e-18 2.424e-16
63 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 14 121 3.804e-18 2.81e-16
64 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 25 801 4.16e-18 3.025e-16
65 PATTERN SPECIFICATION PROCESS 20 418 5.268e-18 3.771e-16
66 NEGATIVE REGULATION OF CELL PROLIFERATION 23 643 6.485e-18 4.572e-16
67 PHOSPHORYLATION 29 1228 7.033e-18 4.884e-16
68 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 27 1021 8.523e-18 5.832e-16
69 HEART DEVELOPMENT 20 466 4.347e-17 2.931e-15
70 MESODERM DEVELOPMENT 13 118 1.272e-16 8.458e-15
71 GASTRULATION 14 155 1.334e-16 8.744e-15
72 BONE DEVELOPMENT 14 156 1.462e-16 9.448e-15
73 REGULATION OF CARTILAGE DEVELOPMENT 11 63 1.61e-16 1.026e-14
74 REGULATION OF CELL CYCLE 25 949 2.225e-16 1.399e-14
75 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 11 66 2.786e-16 1.684e-14
76 KIDNEY EPITHELIUM DEVELOPMENT 13 125 2.751e-16 1.684e-14
77 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 11 66 2.786e-16 1.684e-14
78 TISSUE MORPHOGENESIS 20 533 5.752e-16 3.431e-14
79 EMBRYONIC MORPHOGENESIS 20 539 7.124e-16 4.196e-14
80 RESPONSE TO ORGANIC CYCLIC COMPOUND 24 917 1.218e-15 7.086e-14
81 POSITIVE REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 7 12 2.986e-15 1.715e-13
82 SKELETAL SYSTEM MORPHOGENESIS 14 201 5.201e-15 2.951e-13
83 POSITIVE REGULATION OF CELL DEATH 20 605 6.396e-15 3.586e-13
84 CARDIOVASCULAR SYSTEM DEVELOPMENT 22 788 6.833e-15 3.74e-13
85 CIRCULATORY SYSTEM DEVELOPMENT 22 788 6.833e-15 3.74e-13
86 GLAND DEVELOPMENT 17 395 1.347e-14 7.29e-13
87 MESODERM MORPHOGENESIS 10 66 1.879e-14 1.005e-12
88 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 17 404 1.948e-14 1.03e-12
89 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 10 67 2.203e-14 1.152e-12
90 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 21 740 2.36e-14 1.22e-12
91 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 31 1977 3.168e-14 1.62e-12
92 REGULATION OF MAPK CASCADE 20 660 3.289e-14 1.664e-12
93 REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 7 16 4.268e-14 2.135e-12
94 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 8 29 4.731e-14 2.342e-12
95 REGULATION OF CELLULAR COMPONENT MOVEMENT 21 771 5.259e-14 2.576e-12
96 RHYTHMIC PROCESS 15 298 6.081e-14 2.947e-12
97 DIGESTIVE SYSTEM DEVELOPMENT 12 148 8.756e-14 4.2e-12
98 REGIONALIZATION 15 311 1.134e-13 5.383e-12
99 REGULATION OF STEM CELL DIFFERENTIATION 11 113 1.333e-13 6.267e-12
100 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 17 465 1.917e-13 8.919e-12
101 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 8 34 1.975e-13 9.097e-12
102 POSITIVE REGULATION OF CELL DEVELOPMENT 17 472 2.44e-13 1.113e-11
103 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 22 957 3.515e-13 1.588e-11
104 EPITHELIAL CELL DIFFERENTIATION 17 495 5.249e-13 2.348e-11
105 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 11 129 5.85e-13 2.592e-11
106 REGULATION OF EPITHELIAL CELL PROLIFERATION 14 285 6.406e-13 2.812e-11
107 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 25 1360 8.068e-13 3.509e-11
108 NEGATIVE REGULATION OF CELL CYCLE 16 433 9.282e-13 3.999e-11
109 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 18 602 1.004e-12 4.288e-11
110 MESENCHYME DEVELOPMENT 12 190 1.744e-12 7.379e-11
111 POSITIVE REGULATION OF PROTEIN IMPORT 10 104 2.102e-12 8.812e-11
112 ODONTOGENESIS 10 105 2.317e-12 9.627e-11
113 OSSIFICATION 13 251 2.387e-12 9.828e-11
114 TUBE MORPHOGENESIS 14 323 3.486e-12 1.423e-10
115 FORMATION OF PRIMARY GERM LAYER 10 110 3.718e-12 1.504e-10
116 REGULATION OF BMP SIGNALING PATHWAY 9 77 4.71e-12 1.889e-10
117 EMBRYONIC ORGAN DEVELOPMENT 15 406 5.276e-12 2.098e-10
118 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 8 50 5.595e-12 2.206e-10
119 NEGATIVE REGULATION OF GENE EXPRESSION 25 1493 6.321e-12 2.472e-10
120 RESPONSE TO LIPID 20 888 7.815e-12 3.03e-10
121 POSITIVE REGULATION OF LOCOMOTION 15 420 8.543e-12 3.285e-10
122 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 12 218 8.842e-12 3.372e-10
123 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 25 1517 8.958e-12 3.389e-10
124 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 10 121 9.742e-12 3.656e-10
125 REGULATION OF BINDING 13 283 1.084e-11 4.036e-10
126 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 22 1152 1.382e-11 5.102e-10
127 NEGATIVE REGULATION OF CELL DIFFERENTIATION 17 609 1.416e-11 5.187e-10
128 POSITIVE REGULATION OF CELL PROLIFERATION 19 814 1.587e-11 5.768e-10
129 REPRODUCTION 23 1297 1.853e-11 6.685e-10
130 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 10 131 2.163e-11 7.741e-10
131 MESENCHYMAL CELL DIFFERENTIATION 10 134 2.713e-11 9.562e-10
132 REGULATION OF PROTEIN IMPORT 11 183 2.712e-11 9.562e-10
133 REGULATION OF ORGAN MORPHOGENESIS 12 242 3e-11 1.05e-09
134 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 21 1087 3.695e-11 1.283e-09
135 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 16 554 3.764e-11 1.297e-09
136 GLAND MORPHOGENESIS 9 97 3.956e-11 1.354e-09
137 MESENCHYME MORPHOGENESIS 7 38 4.439e-11 1.508e-09
138 ANTERIOR POSTERIOR PATTERN SPECIFICATION 11 194 5.097e-11 1.719e-09
139 EYE DEVELOPMENT 13 326 6.335e-11 2.121e-09
140 SENSORY ORGAN DEVELOPMENT 15 493 8.162e-11 2.713e-09
141 NEGATIVE REGULATION OF OSSIFICATION 8 69 8.282e-11 2.733e-09
142 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 337 9.556e-11 3.131e-09
143 RESPONSE TO ABIOTIC STIMULUS 20 1024 1.006e-10 3.272e-09
144 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 10 153 1.015e-10 3.279e-09
145 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 10 154 1.082e-10 3.473e-09
146 HEART MORPHOGENESIS 11 212 1.323e-10 4.215e-09
147 HEAD DEVELOPMENT 17 709 1.513e-10 4.79e-09
148 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 162 1.785e-10 5.612e-09
149 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 11 220 1.966e-10 6.138e-09
150 REGULATION OF TRANSFERASE ACTIVITY 19 946 2.065e-10 6.393e-09
151 REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY 6 25 2.075e-10 6.393e-09
152 REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 363 2.388e-10 7.31e-09
153 MORPHOGENESIS OF A BRANCHING STRUCTURE 10 167 2.408e-10 7.323e-09
154 BONE MORPHOGENESIS 8 79 2.516e-10 7.602e-09
155 CELL CYCLE PROCESS 20 1081 2.618e-10 7.859e-09
156 CELL FATE COMMITMENT 11 227 2.745e-10 8.188e-09
157 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 8 80 2.788e-10 8.263e-09
158 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 541 2.969e-10 8.687e-09
159 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 541 2.969e-10 8.687e-09
160 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 171 3.039e-10 8.837e-09
161 REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 6 27 3.449e-10 9.907e-09
162 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 6 27 3.449e-10 9.907e-09
163 CARDIAC SEPTUM DEVELOPMENT 8 85 4.567e-10 1.288e-08
164 PALATE DEVELOPMENT 8 85 4.567e-10 1.288e-08
165 RESPONSE TO OXYGEN CONTAINING COMPOUND 22 1381 4.525e-10 1.288e-08
166 REGULATION OF MITOTIC CELL CYCLE 14 468 4.727e-10 1.325e-08
167 CELL DEATH 19 1001 5.341e-10 1.488e-08
168 REGULATION OF HEART MORPHOGENESIS 6 29 5.506e-10 1.525e-08
169 NEUROGENESIS 22 1402 6.019e-10 1.657e-08
170 CELL PROLIFERATION 16 672 6.392e-10 1.75e-08
171 RESPONSE TO HORMONE 18 893 6.487e-10 1.765e-08
172 CRANIAL SKELETAL SYSTEM DEVELOPMENT 7 55 6.82e-10 1.845e-08
173 MORPHOGENESIS OF AN EPITHELIUM 13 400 7.82e-10 2.103e-08
174 STEM CELL DIFFERENTIATION 10 190 8.516e-10 2.277e-08
175 REPRODUCTIVE SYSTEM DEVELOPMENT 13 408 9.948e-10 2.645e-08
176 EMBRYONIC PATTERN SPECIFICATION 7 58 1.002e-09 2.65e-08
177 RESPONSE TO STEROID HORMONE 14 497 1.03e-09 2.708e-08
178 ENDOCARDIAL CUSHION DEVELOPMENT 6 32 1.042e-09 2.724e-08
179 DEVELOPMENTAL GROWTH 12 333 1.177e-09 3.06e-08
180 RESPIRATORY SYSTEM DEVELOPMENT 10 197 1.211e-09 3.13e-08
181 CELL CYCLE 21 1316 1.232e-09 3.167e-08
182 CHONDROCYTE DIFFERENTIATION 7 60 1.281e-09 3.275e-08
183 SEX DIFFERENTIATION 11 266 1.47e-09 3.737e-08
184 HEART VALVE DEVELOPMENT 6 34 1.538e-09 3.89e-08
185 REGULATION OF EPIDERMIS DEVELOPMENT 7 63 1.82e-09 4.578e-08
186 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 23 1656 2.331e-09 5.832e-08
187 CELL CYCLE ARREST 9 154 2.516e-09 6.261e-08
188 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 12 360 2.838e-09 7.024e-08
189 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 16 750 3.102e-09 7.636e-08
190 REGULATION OF DEPHOSPHORYLATION 9 158 3.155e-09 7.726e-08
191 REGULATION OF CELL MORPHOGENESIS 14 552 3.96e-09 9.647e-08
192 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 6 40 4.321e-09 1.047e-07
193 REGULATION OF CELL CYCLE PROCESS 14 558 4.545e-09 1.096e-07
194 REGULATION OF KINASE ACTIVITY 16 776 5.038e-09 1.208e-07
195 VASCULATURE DEVELOPMENT 13 469 5.329e-09 1.272e-07
196 REGULATION OF VASCULATURE DEVELOPMENT 10 233 6.113e-09 1.451e-07
197 ARTERY DEVELOPMENT 7 75 6.324e-09 1.494e-07
198 REGULATION OF PROTEIN TARGETING 11 307 6.568e-09 1.543e-07
199 NEGATIVE REGULATION OF GROWTH 10 236 6.91e-09 1.616e-07
200 RESPONSE TO OXYGEN LEVELS 11 311 7.511e-09 1.747e-07
201 IMMUNE SYSTEM DEVELOPMENT 14 582 7.757e-09 1.796e-07
202 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 8 122 8.277e-09 1.907e-07
203 ENDOCHONDRAL BONE MORPHOGENESIS 6 45 9.048e-09 2.074e-07
204 REGULATION OF CHONDROCYTE DIFFERENTIATION 6 46 1.038e-08 2.355e-07
205 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 6 46 1.038e-08 2.355e-07
206 REGULATION OF PHOSPHATASE ACTIVITY 8 128 1.209e-08 2.732e-07
207 DIGESTIVE TRACT MORPHOGENESIS 6 48 1.352e-08 3.04e-07
208 CELL CYCLE PHASE TRANSITION 10 255 1.446e-08 3.235e-07
209 MYELOID CELL DIFFERENTIATION 9 189 1.514e-08 3.37e-07
210 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 513 1.547e-08 3.429e-07
211 RESPONSE TO STEROL 5 24 1.581e-08 3.484e-07
212 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 14 616 1.587e-08 3.484e-07
213 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 258 1.616e-08 3.53e-07
214 OVULATION CYCLE PROCESS 7 88 1.954e-08 4.248e-07
215 REGULATION OF CELL ADHESION 14 629 2.063e-08 4.464e-07
216 REGULATION OF GROWTH 14 633 2.233e-08 4.81e-07
217 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 9 199 2.368e-08 5.077e-07
218 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 6 53 2.496e-08 5.328e-07
219 CENTRAL NERVOUS SYSTEM DEVELOPMENT 16 872 2.599e-08 5.522e-07
220 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 7 93 2.877e-08 6.084e-07
221 MUSCLE TISSUE DEVELOPMENT 10 275 2.956e-08 6.224e-07
222 CARDIAC CHAMBER DEVELOPMENT 8 144 3.049e-08 6.391e-07
223 EMBRYONIC ORGAN MORPHOGENESIS 10 279 3.388e-08 7.037e-07
224 MULTICELLULAR ORGANISM REPRODUCTION 15 768 3.382e-08 7.037e-07
225 EPITHELIAL TO MESENCHYMAL TRANSITION 6 56 3.503e-08 7.243e-07
226 GASTRULATION WITH MOUTH FORMING SECOND 5 28 3.618e-08 7.449e-07
227 REGULATION OF CELLULAR PROTEIN LOCALIZATION 13 552 3.664e-08 7.51e-07
228 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 10 282 3.747e-08 7.646e-07
229 MALE SEX DIFFERENTIATION 8 148 3.777e-08 7.674e-07
230 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 7 98 4.145e-08 8.385e-07
231 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 11 370 4.471e-08 9.006e-07
232 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 7 103 5.857e-08 1.175e-06
233 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 11 381 6.021e-08 1.202e-06
234 SALIVARY GLAND DEVELOPMENT 5 32 7.336e-08 1.459e-06
235 REGULATION OF PROTEIN LOCALIZATION 16 950 8.495e-08 1.682e-06
236 REGULATION OF EPITHELIAL CELL MIGRATION 8 166 9.208e-08 1.815e-06
237 IN UTERO EMBRYONIC DEVELOPMENT 10 311 9.373e-08 1.84e-06
238 CELL CYCLE G1 S PHASE TRANSITION 7 111 9.828e-08 1.913e-06
239 G1 S TRANSITION OF MITOTIC CELL CYCLE 7 111 9.828e-08 1.913e-06
240 REGULATION OF MESENCHYMAL CELL PROLIFERATION 5 34 1.008e-07 1.942e-06
241 PROTEIN KINASE B SIGNALING 5 34 1.008e-07 1.942e-06
242 RESPONSE TO CARBOHYDRATE 8 168 1.01e-07 1.942e-06
243 APPENDAGE DEVELOPMENT 8 169 1.057e-07 2.016e-06
244 LIMB DEVELOPMENT 8 169 1.057e-07 2.016e-06
245 OVULATION CYCLE 7 113 1.112e-07 2.111e-06
246 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 11 406 1.144e-07 2.147e-06
247 ORGAN GROWTH 6 68 1.144e-07 2.147e-06
248 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 6 68 1.144e-07 2.147e-06
249 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 14 1.192e-07 2.219e-06
250 RESPONSE TO LAMINAR FLUID SHEAR STRESS 4 14 1.192e-07 2.219e-06
251 REGULATION OF CELL CYCLE PHASE TRANSITION 10 321 1.258e-07 2.333e-06
252 LOCOMOTION 17 1114 1.279e-07 2.362e-06
253 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 12 514 1.438e-07 2.645e-06
254 ENDODERM DEVELOPMENT 6 71 1.485e-07 2.72e-06
255 INTRACELLULAR SIGNAL TRANSDUCTION 20 1572 1.507e-07 2.75e-06
256 REGULATION OF HAIR FOLLICLE DEVELOPMENT 4 15 1.622e-07 2.947e-06
257 NEGATIVE REGULATION OF PHOSPHORYLATION 11 422 1.687e-07 3.054e-06
258 POSITIVE REGULATION OF CELL CYCLE 10 332 1.72e-07 3.101e-06
259 NEGATIVE REGULATION OF CELL DEATH 15 872 1.769e-07 3.179e-06
260 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 9 252 1.79e-07 3.203e-06
261 RESPONSE TO KETONE 8 182 1.87e-07 3.334e-06
262 ENDOCRINE SYSTEM DEVELOPMENT 7 123 1.99e-07 3.535e-06
263 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 6 75 2.065e-07 3.654e-06
264 OSTEOBLAST DIFFERENTIATION 7 126 2.347e-07 4.121e-06
265 MITOTIC CELL CYCLE 14 766 2.345e-07 4.121e-06
266 REGULATION OF CELLULAR COMPONENT BIOGENESIS 14 767 2.382e-07 4.167e-06
267 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 11 437 2.391e-07 4.167e-06
268 CELLULAR COMPONENT MORPHOGENESIS 15 900 2.655e-07 4.61e-06
269 REGULATION OF REPRODUCTIVE PROCESS 7 129 2.756e-07 4.768e-06
270 REGULATION OF HOMEOSTATIC PROCESS 11 447 2.995e-07 5.162e-06
271 REGULATION OF NEURON DIFFERENTIATION 12 554 3.212e-07 5.516e-06
272 IMMUNE SYSTEM PROCESS 22 1984 3.297e-07 5.639e-06
273 RESPONSE TO ALCOHOL 10 362 3.815e-07 6.502e-06
274 ACTIVATION OF PROTEIN KINASE ACTIVITY 9 279 4.221e-07 7.168e-06
275 EXOCRINE SYSTEM DEVELOPMENT 5 45 4.302e-07 7.278e-06
276 POSITIVE REGULATION OF CELL CYCLE ARREST 6 85 4.368e-07 7.364e-06
277 ATRIOVENTRICULAR VALVE DEVELOPMENT 4 19 4.558e-07 7.628e-06
278 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 4 19 4.558e-07 7.628e-06
279 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 5 46 4.814e-07 7.999e-06
280 CARDIAC MUSCLE TISSUE DEVELOPMENT 7 140 4.809e-07 7.999e-06
281 TISSUE REMODELING 6 87 5.017e-07 8.307e-06
282 REGULATION OF STEM CELL PROLIFERATION 6 88 5.369e-07 8.859e-06
283 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 4 20 5.682e-07 9.343e-06
284 AXIS SPECIFICATION 6 90 6.136e-07 1.002e-05
285 ENDOTHELIUM DEVELOPMENT 6 90 6.136e-07 1.002e-05
286 REGULATION OF CYTOPLASMIC TRANSPORT 11 481 6.186e-07 1.006e-05
287 DORSAL VENTRAL PATTERN FORMATION 6 91 6.552e-07 1.062e-05
288 REGULATION OF IMMUNE SYSTEM PROCESS 18 1403 6.62e-07 1.069e-05
289 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 7 147 6.691e-07 1.077e-05
290 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 8 216 6.89e-07 1.106e-05
291 CELLULAR RESPONSE TO STRESS 19 1565 6.918e-07 1.106e-05
292 REGULATION OF CELL GROWTH 10 391 7.703e-07 1.228e-05
293 NEGATIVE REGULATION OF CELL DEVELOPMENT 9 303 8.407e-07 1.335e-05
294 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 4 22 8.536e-07 1.342e-05
295 REGULATION OF HAIR CYCLE 4 22 8.536e-07 1.342e-05
296 ENDOCARDIAL CUSHION MORPHOGENESIS 4 22 8.536e-07 1.342e-05
297 REGULATION OF CELLULAR LOCALIZATION 17 1277 8.771e-07 1.374e-05
298 POSITIVE REGULATION OF NEURON DIFFERENTIATION 9 306 9.124e-07 1.425e-05
299 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 12 616 9.864e-07 1.535e-05
300 PROTEIN LOCALIZATION TO NUCLEUS 7 156 9.985e-07 1.549e-05
301 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 6 98 1.016e-06 1.57e-05
302 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 4 23 1.031e-06 1.583e-05
303 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 4 23 1.031e-06 1.583e-05
304 REGULATION OF INTRACELLULAR TRANSPORT 12 621 1.074e-06 1.643e-05
305 VENTRICULAR SEPTUM DEVELOPMENT 5 54 1.087e-06 1.659e-05
306 NEURON DIFFERENTIATION 14 874 1.14e-06 1.733e-05
307 NEGATIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 5 55 1.193e-06 1.808e-05
308 NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION 4 24 1.234e-06 1.858e-05
309 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 4 24 1.234e-06 1.858e-05
310 REGULATION OF MAP KINASE ACTIVITY 9 319 1.288e-06 1.933e-05
311 REGULATION OF MUSCLE TISSUE DEVELOPMENT 6 103 1.361e-06 2.03e-05
312 REGULATION OF MUSCLE ORGAN DEVELOPMENT 6 103 1.361e-06 2.03e-05
313 MULTI ORGANISM REPRODUCTIVE PROCESS 14 891 1.431e-06 2.127e-05
314 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 4 25 1.465e-06 2.171e-05
315 RESPONSE TO EXTERNAL STIMULUS 20 1821 1.572e-06 2.323e-05
316 REGULATION OF FAT CELL DIFFERENTIATION 6 106 1.611e-06 2.372e-05
317 NEGATIVE REGULATION OF CELL GROWTH 7 170 1.775e-06 2.606e-05
318 REGULATION OF CELL CYCLE ARREST 6 108 1.798e-06 2.63e-05
319 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 60 1.849e-06 2.688e-05
320 REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 60 1.849e-06 2.688e-05
321 POSITIVE REGULATION OF CELL CYCLE PROCESS 8 247 1.885e-06 2.733e-05
322 OVARIAN FOLLICLE DEVELOPMENT 5 61 2.008e-06 2.893e-05
323 POSITIVE REGULATION OF STEM CELL PROLIFERATION 5 61 2.008e-06 2.893e-05
324 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 4 27 2.022e-06 2.904e-05
325 POSITIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 6 111 2.11e-06 3.021e-05
326 RESPONSE TO CORTICOSTEROID 7 176 2.237e-06 3.193e-05
327 RESPONSE TO EXTRACELLULAR STIMULUS 10 441 2.276e-06 3.239e-05
328 REGULATION OF ENDOTHELIAL CELL MIGRATION 6 114 2.466e-06 3.487e-05
329 NOTCH SIGNALING PATHWAY 6 114 2.466e-06 3.487e-05
330 POSITIVE REGULATION OF TRANSPORT 14 936 2.549e-06 3.595e-05
331 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 6 115 2.595e-06 3.637e-05
332 NEGATIVE REGULATION OF MOLECULAR FUNCTION 15 1079 2.594e-06 3.637e-05
333 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 29 2.722e-06 3.802e-05
334 FEMALE SEX DIFFERENTIATION 6 116 2.729e-06 3.802e-05
335 REGULATION OF CYTOKINE PRODUCTION 11 563 2.859e-06 3.972e-05
336 SPECIFICATION OF SYMMETRY 6 117 2.869e-06 3.973e-05
337 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 262 2.922e-06 4.031e-05
338 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 684 2.928e-06 4.031e-05
339 LENS DEVELOPMENT IN CAMERA TYPE EYE 5 66 2.978e-06 4.087e-05
340 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 9 354 3.027e-06 4.143e-05
341 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 5 67 3.21e-06 4.367e-05
342 NEURON FATE COMMITMENT 5 67 3.21e-06 4.367e-05
343 FOREBRAIN DEVELOPMENT 9 357 3.243e-06 4.399e-05
344 REGULATION OF CELL JUNCTION ASSEMBLY 5 68 3.455e-06 4.674e-05
345 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 3.659e-06 4.935e-05
346 POSITIVE REGULATION OF PROTEOLYSIS 9 363 3.714e-06 4.994e-05
347 BLOOD VESSEL MORPHOGENESIS 9 364 3.798e-06 5.092e-05
348 REGULATION OF MULTI ORGANISM PROCESS 10 470 4.008e-06 5.344e-05
349 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 470 4.008e-06 5.344e-05
350 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 4 32 4.09e-06 5.422e-05
351 POSITIVE REGULATION OF EPIDERMIS DEVELOPMENT 4 32 4.09e-06 5.422e-05
352 POSITIVE REGULATION OF SECRETION 9 370 4.337e-06 5.733e-05
353 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 9 372 4.53e-06 5.972e-05
354 ENDOTHELIAL CELL DIFFERENTIATION 5 72 4.589e-06 6.032e-05
355 POSITIVE REGULATION OF BINDING 6 127 4.617e-06 6.052e-05
356 REGULATION OF HORMONE LEVELS 10 478 4.653e-06 6.064e-05
357 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 4 33 4.642e-06 6.064e-05
358 GAMETE GENERATION 11 595 4.85e-06 6.304e-05
359 POSITIVE REGULATION OF CELL ADHESION 9 376 4.94e-06 6.403e-05
360 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 5.007e-06 6.472e-05
361 RESPONSE TO FLUID SHEAR STRESS 4 34 5.248e-06 6.764e-05
362 REGULATION OF TRANSPORT 19 1804 5.75e-06 7.391e-05
363 REGULATION OF RESPONSE TO STRESS 17 1468 5.851e-06 7.5e-05
364 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 13 867 5.994e-06 7.662e-05
365 POSITIVE REGULATION OF HAIR CYCLE 3 11 6.083e-06 7.754e-05
366 REGULATION OF PROTEIN SECRETION 9 389 6.5e-06 8.263e-05
367 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 4 36 6.631e-06 8.385e-05
368 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 36 6.631e-06 8.385e-05
369 ANGIOGENESIS 8 293 6.655e-06 8.391e-05
370 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 296 7.169e-06 9.015e-05
371 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 7 211 7.4e-06 9.281e-05
372 REGULATION OF ORGANELLE ORGANIZATION 15 1178 7.55e-06 9.444e-05
373 MITOTIC CELL CYCLE CHECKPOINT 6 139 7.769e-06 9.692e-05
374 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 3 12 8.091e-06 9.986e-05
375 ANATOMICAL STRUCTURE REGRESSION 3 12 8.091e-06 9.986e-05
376 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 3 12 8.091e-06 9.986e-05
377 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 3 12 8.091e-06 9.986e-05
378 NEGATIVE REGULATION OF CELL CYCLE PROCESS 7 214 8.115e-06 9.989e-05
379 METANEPHROS DEVELOPMENT 5 81 8.208e-06 0.0001008
380 REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 4 38 8.268e-06 0.0001012
381 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 7 216 8.623e-06 0.0001053
382 RESPONSE TO ESTROGEN 7 218 9.157e-06 0.0001115
383 NEGATIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 3 13 1.049e-05 0.0001262
384 REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT 3 13 1.049e-05 0.0001262
385 MESENCHYMAL CELL PROLIFERATION 3 13 1.049e-05 0.0001262
386 REGULATION OF GONADOTROPIN SECRETION 3 13 1.049e-05 0.0001262
387 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 3 13 1.049e-05 0.0001262
388 REGULATION OF HEMOPOIESIS 8 314 1.102e-05 0.0001321
389 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 4 41 1.126e-05 0.0001346
390 PITUITARY GLAND DEVELOPMENT 4 42 1.241e-05 0.0001477
391 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 4 42 1.241e-05 0.0001477
392 REGULATION OF MUSCLE CELL DIFFERENTIATION 6 152 1.296e-05 0.0001538
393 SEGMENTATION 5 89 1.302e-05 0.0001538
394 EPITHELIAL CELL PROLIFERATION 5 89 1.302e-05 0.0001538
395 CRANIOFACIAL SUTURE MORPHOGENESIS 3 14 1.332e-05 0.0001569
396 REGULATION OF LEUKOCYTE DIFFERENTIATION 7 232 1.372e-05 0.0001612
397 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 4 44 1.497e-05 0.0001755
398 POSITIVE REGULATION OF MULTI ORGANISM PROCESS 6 157 1.558e-05 0.0001821
399 REGULATION OF DNA BINDING 5 93 1.613e-05 0.0001881
400 POSITIVE REGULATION OF GROWTH 7 238 1.618e-05 0.0001882
401 LUNG MORPHOGENESIS 4 45 1.639e-05 0.0001902
402 NEGATIVE REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 3 15 1.661e-05 0.0001918
403 VENOUS BLOOD VESSEL DEVELOPMENT 3 15 1.661e-05 0.0001918
404 REGULATION OF DNA REPLICATION 6 161 1.797e-05 0.0002069
405 CARDIOCYTE DIFFERENTIATION 5 96 1.883e-05 0.0002163
406 POSITIVE REGULATION OF HEMOPOIESIS 6 163 1.927e-05 0.0002208
407 RESPONSE TO WOUNDING 10 563 1.933e-05 0.0002208
408 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 15 1275 1.936e-05 0.0002208
409 REGULATION OF DNA METABOLIC PROCESS 8 340 1.955e-05 0.0002224
410 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 9 448 2.003e-05 0.0002273
411 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 12 829 2.039e-05 0.0002298
412 PARAXIAL MESODERM DEVELOPMENT 3 16 2.039e-05 0.0002298
413 ATRIOVENTRICULAR VALVE MORPHOGENESIS 3 16 2.039e-05 0.0002298
414 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 98 2.081e-05 0.0002333
415 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 98 2.081e-05 0.0002333
416 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 2.124e-05 0.0002365
417 REGULATION OF MYOBLAST DIFFERENTIATION 4 48 2.124e-05 0.0002365
418 REGULATION OF ENDOCRINE PROCESS 4 48 2.124e-05 0.0002365
419 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 99 2.186e-05 0.0002427
420 REGULATION OF SECRETION 11 699 2.194e-05 0.0002431
421 REGULATION OF PROTEIN BINDING 6 168 2.286e-05 0.0002526
422 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 100 2.295e-05 0.000253
423 CARDIAC SEPTUM MORPHOGENESIS 4 49 2.307e-05 0.0002538
424 CELLULAR RESPONSE TO LIPID 9 457 2.342e-05 0.000257
425 POSITIVE REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 3 17 2.47e-05 0.0002705
426 REGULATION OF ADHERENS JUNCTION ORGANIZATION 4 50 2.502e-05 0.0002726
427 RESPONSE TO PROGESTERONE 4 50 2.502e-05 0.0002726
428 POSITIVE REGULATION OF MAPK CASCADE 9 470 2.918e-05 0.0003172
429 PERICARDIUM DEVELOPMENT 3 18 2.957e-05 0.00032
430 KIDNEY MESENCHYME DEVELOPMENT 3 18 2.957e-05 0.00032
431 REGULATION OF HORMONE SECRETION 7 262 2.997e-05 0.0003236
432 CARDIAC VENTRICLE DEVELOPMENT 5 106 3.041e-05 0.0003267
433 FAT CELL DIFFERENTIATION 5 106 3.041e-05 0.0003267
434 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 4 53 3.156e-05 0.0003376
435 MESONEPHRIC TUBULE MORPHOGENESIS 4 53 3.156e-05 0.0003376
436 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 8 365 3.244e-05 0.0003462
437 SEXUAL REPRODUCTION 11 730 3.267e-05 0.0003479
438 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 3.503e-05 0.0003722
439 REGULATION OF KIDNEY DEVELOPMENT 4 55 3.658e-05 0.0003877
440 REGULATION OF CELL DIVISION 7 272 3.805e-05 0.0004023
441 DORSAL VENTRAL AXIS SPECIFICATION 3 20 4.112e-05 0.0004338
442 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 4 57 4.215e-05 0.0004437
443 NEPHRON DEVELOPMENT 5 115 4.497e-05 0.0004724
444 RESPONSE TO NUTRIENT 6 191 4.694e-05 0.000492
445 CHONDROCYTE DEVELOPMENT 3 21 4.785e-05 0.0004992
446 REGULATION OF LIPID METABOLIC PROCESS 7 282 4.783e-05 0.0004992
447 REGULATION OF GLIAL CELL DIFFERENTIATION 4 59 4.831e-05 0.0005029
448 MAMMARY GLAND DEVELOPMENT 5 117 4.884e-05 0.0005073
449 CELL CYCLE CHECKPOINT 6 194 5.12e-05 0.0005306
450 STEM CELL PROLIFERATION 4 60 5.163e-05 0.0005339
451 REGULATION OF SYSTEM PROCESS 9 507 5.256e-05 0.0005423
452 EMBRYONIC DIGIT MORPHOGENESIS 4 61 5.511e-05 0.000564
453 POSITIVE REGULATION OF TRANSLATIONAL INITIATION 3 22 5.527e-05 0.000564
454 DSRNA FRAGMENTATION 3 22 5.527e-05 0.000564
455 POSITIVE REGULATION OF CHEMOTAXIS 5 120 5.512e-05 0.000564
456 PRODUCTION OF SMALL RNA INVOLVED IN GENE SILENCING BY RNA 3 22 5.527e-05 0.000564
457 APOPTOTIC SIGNALING PATHWAY 7 289 5.583e-05 0.0005685
458 SOMITOGENESIS 4 62 5.876e-05 0.000597
459 POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION 3 23 6.341e-05 0.00064
460 SCF DEPENDENT PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 3 23 6.341e-05 0.00064
461 REGULATION OF SUPEROXIDE METABOLIC PROCESS 3 23 6.341e-05 0.00064
462 POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 24 7.229e-05 0.0007249
463 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 24 7.229e-05 0.0007249
464 REGULATION OF ODONTOGENESIS 3 24 7.229e-05 0.0007249
465 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 7 303 7.515e-05 0.000752
466 POSITIVE REGULATION OF MOLECULAR FUNCTION 17 1791 7.63e-05 0.0007619
467 GERM CELL DEVELOPMENT 6 209 7.736e-05 0.0007708
468 NUCLEAR IMPORT 5 129 7.775e-05 0.000773
469 RESPONSE TO MECHANICAL STIMULUS 6 210 7.942e-05 0.000788
470 POSITIVE REGULATION OF PROTEIN SECRETION 6 211 8.153e-05 0.0008071
471 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 213 8.588e-05 0.0008484
472 REGULATION OF LYMPHOCYTE DIFFERENTIATION 5 132 8.67e-05 0.0008547
473 REGULATION OF ACTIN FILAMENT BASED PROCESS 7 312 9.023e-05 0.0008876
474 NEGATIVE REGULATION OF GLIAL CELL DIFFERENTIATION 3 26 9.241e-05 0.0009033
475 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 3 26 9.241e-05 0.0009033
476 MESODERMAL CELL DIFFERENTIATION 3 26 9.241e-05 0.0009033
477 PROTEIN COMPLEX BIOGENESIS 13 1132 9.753e-05 0.0009478
478 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 6 218 9.757e-05 0.0009478
479 PROTEIN COMPLEX ASSEMBLY 13 1132 9.753e-05 0.0009478
480 NEGATIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 5 136 9.983e-05 0.0009677
481 CELLULAR RESPONSE TO HORMONE STIMULUS 9 552 0.0001007 0.0009746
482 CIRCADIAN RHYTHM 5 137 0.0001033 0.0009976
483 REGULATION OF ASTROCYTE DIFFERENTIATION 3 27 0.0001037 0.0009991
484 RESPONSE TO DRUG 8 431 0.000104 0.0009996
485 MUSCLE STRUCTURE DEVELOPMENT 8 432 0.0001057 0.001014
486 REGULATION OF CELLULAR RESPONSE TO STRESS 10 691 0.0001081 0.001035
487 CELL MOTILITY 11 835 0.0001093 0.001042
488 LOCALIZATION OF CELL 11 835 0.0001093 0.001042
489 ERYTHROCYTE HOMEOSTASIS 4 73 0.0001115 0.001056
490 PANCREAS DEVELOPMENT 4 73 0.0001115 0.001056
491 G1 DNA DAMAGE CHECKPOINT 4 73 0.0001115 0.001056
492 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 0.0001159 0.001096
493 NEGATIVE REGULATION OF HORMONE SECRETION 4 74 0.0001176 0.001109
494 NEURAL CREST CELL DIFFERENTIATION 4 75 0.0001239 0.001167
495 REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 3 29 0.0001289 0.001209
496 REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 3 29 0.0001289 0.001209
497 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 9 573 0.0001336 0.001251
498 NEGATIVE REGULATION OF DEPHOSPHORYLATION 4 77 0.0001372 0.001274
499 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 4 77 0.0001372 0.001274
500 DIENCEPHALON DEVELOPMENT 4 77 0.0001372 0.001274
501 REGULATION OF PROTEOLYSIS 10 711 0.0001365 0.001274
502 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 5 146 0.0001394 0.001292
503 RESPONSE TO NITROGEN COMPOUND 11 859 0.0001403 0.001298
504 POSITIVE REGULATION OF CATALYTIC ACTIVITY 15 1518 0.0001424 0.001314
505 SMOOTH MUSCLE CELL DIFFERENTIATION 3 30 0.0001429 0.001317
506 RENAL TUBULE DEVELOPMENT 4 78 0.0001442 0.001324
507 SOMITE DEVELOPMENT 4 78 0.0001442 0.001324
508 POSITIVE REGULATION OF CELL GROWTH 5 148 0.0001486 0.001359
509 INFLAMMATORY RESPONSE 8 454 0.0001487 0.001359
510 PROTEIN COMPLEX SUBUNIT ORGANIZATION 15 1527 0.000152 0.001387
511 NEGATIVE REGULATION OF TRANSPORT 8 458 0.0001579 0.001437
512 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 10 724 0.0001582 0.001438
513 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 4 81 0.000167 0.001509
514 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 11 876 0.0001665 0.001509
515 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 0.000167 0.001509
516 BIOLOGICAL ADHESION 12 1032 0.0001673 0.001509
517 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 152 0.0001683 0.001515
518 REGULATION OF ORGAN FORMATION 3 32 0.0001737 0.001552
519 PATTERNING OF BLOOD VESSELS 3 32 0.0001737 0.001552
520 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 0.0001737 0.001552
521 BLOOD VESSEL REMODELING 3 32 0.0001737 0.001552
522 KIDNEY MORPHOGENESIS 4 82 0.0001751 0.001558
523 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 4 82 0.0001751 0.001558
524 PROTEOGLYCAN METABOLIC PROCESS 4 83 0.0001835 0.001629
525 PROTEIN IMPORT 5 155 0.0001844 0.001634
526 WNT SIGNALING PATHWAY 7 351 0.0001868 0.001653
527 WOUND HEALING 8 470 0.0001883 0.001663
528 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 5 156 0.00019 0.001674
529 EMBRYONIC AXIS SPECIFICATION 3 33 0.0001906 0.001677
530 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 85 0.0002011 0.001766
531 ORGAN FORMATION 3 34 0.0002086 0.001824
532 OLIGODENDROCYTE DEVELOPMENT 3 34 0.0002086 0.001824
533 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0002104 0.001837
534 MACROMOLECULAR COMPLEX ASSEMBLY 14 1398 0.0002155 0.001877
535 MYELOID CELL HOMEOSTASIS 4 88 0.0002299 0.001996
536 CELLULAR MACROMOLECULE LOCALIZATION 13 1234 0.0002298 0.001996
537 POST EMBRYONIC DEVELOPMENT 4 89 0.0002401 0.00208
538 REGULATION OF ERYTHROCYTE DIFFERENTIATION 3 36 0.0002477 0.00213
539 POSITIVE REGULATION OF PROTEIN ACETYLATION 3 36 0.0002477 0.00213
540 CORTICAL CYTOSKELETON ORGANIZATION 3 36 0.0002477 0.00213
541 HEAD MORPHOGENESIS 3 36 0.0002477 0.00213
542 REGULATION OF CELL MATRIX ADHESION 4 90 0.0002506 0.002144
543 REGULATION OF GLIOGENESIS 4 90 0.0002506 0.002144
544 ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 4 90 0.0002506 0.002144
545 NEGATIVE REGULATION OF GLIOGENESIS 3 37 0.0002689 0.002287
546 HINDLIMB MORPHOGENESIS 3 37 0.0002689 0.002287
547 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 37 0.0002689 0.002287
548 NEGATIVE REGULATION OF LOCOMOTION 6 263 0.0002702 0.002294
549 AGING 6 264 0.0002757 0.002337
550 NEPHRON EPITHELIUM DEVELOPMENT 4 93 0.0002842 0.002404
551 PROTEIN LOCALIZATION 16 1805 0.0002869 0.002423
552 RESPONSE TO TESTOSTERONE 3 38 0.0002912 0.00245
553 CELLULAR RESPONSE TO DSRNA 3 38 0.0002912 0.00245
554 REGULATION OF CYTOSKELETON ORGANIZATION 8 502 0.0002939 0.002468
555 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 94 0.0002961 0.002482
556 REGULATION OF CELL CELL ADHESION 7 380 0.0003028 0.002534
557 ANATOMICAL STRUCTURE MATURATION 3 39 0.0003147 0.00262
558 NEGATIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 3 39 0.0003147 0.00262
559 GLANDULAR EPITHELIAL CELL DIFFERENTIATION 3 39 0.0003147 0.00262
560 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 0.0003209 0.002661
561 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 4 96 0.0003209 0.002661
562 HOMEOSTASIS OF NUMBER OF CELLS 5 175 0.0003234 0.002678
563 MAMMARY GLAND MORPHOGENESIS 3 40 0.0003394 0.0028
564 NEGATIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 3 40 0.0003394 0.0028
565 MUSCLE ORGAN DEVELOPMENT 6 277 0.0003564 0.002935
566 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 3 41 0.0003653 0.002998
567 LUNG ALVEOLUS DEVELOPMENT 3 41 0.0003653 0.002998
568 REGULATION OF CHEMOTAXIS 5 180 0.0003681 0.003015
569 REGULATION OF PROTEIN CATABOLIC PROCESS 7 393 0.0003708 0.003033
570 MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM 4 100 0.0003749 0.003055
571 MITOTIC DNA INTEGRITY CHECKPOINT 4 100 0.0003749 0.003055
572 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 101 0.0003894 0.003167
573 POSITIVE REGULATION OF DNA BINDING 3 42 0.0003925 0.003176
574 POSTTRANSCRIPTIONAL GENE SILENCING 3 42 0.0003925 0.003176
575 EPITHELIAL CELL MORPHOGENESIS 3 42 0.0003925 0.003176
576 REGULATION OF MYELOID CELL DIFFERENTIATION 5 183 0.000397 0.003207
577 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 4 102 0.0004042 0.00326
578 POSITIVE REGULATION OF DNA METABOLIC PROCESS 5 185 0.0004173 0.003353
579 CELL JUNCTION ORGANIZATION 5 185 0.0004173 0.003353
580 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 3 43 0.0004209 0.003371
581 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 0.0004209 0.003371
582 EPITHELIAL CELL DEVELOPMENT 5 186 0.0004277 0.003419
583 CARDIAC CHAMBER MORPHOGENESIS 4 104 0.0004352 0.003473
584 REGULATION OF DEVELOPMENTAL GROWTH 6 289 0.0004464 0.003556
585 BODY MORPHOGENESIS 3 44 0.0004506 0.003584
586 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 4 106 0.0004678 0.003714
587 LEUKOCYTE DIFFERENTIATION 6 292 0.0004714 0.003737
588 REGULATION OF EPIDERMAL CELL DIFFERENTIATION 3 45 0.0004816 0.003804
589 REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 45 0.0004816 0.003804
590 PLATELET DEGRANULATION 4 107 0.0004847 0.003822
591 NEGATIVE REGULATION OF PROTEIN SECRETION 4 108 0.0005021 0.003946
592 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 108 0.0005021 0.003946
593 CELLULAR IRON ION HOMEOSTASIS 3 46 0.0005139 0.004026
594 PEPTIDYL THREONINE MODIFICATION 3 46 0.0005139 0.004026
595 RESPONSE TO ANTIBIOTIC 3 47 0.0005476 0.004276
596 POSITIVE REGULATION OF DEPHOSPHORYLATION 3 47 0.0005476 0.004276
597 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 197 0.0005556 0.00433
598 PROTEIN LOCALIZATION TO ORGANELLE 8 556 0.000579 0.004505
599 REGULATION OF LIPID KINASE ACTIVITY 3 48 0.0005827 0.004519
600 EXTRACELLULAR STRUCTURE ORGANIZATION 6 304 0.0005826 0.004519
601 REGULATION OF CELL PROJECTION ORGANIZATION 8 558 0.0005927 0.004589
602 NEGATIVE REGULATION OF SECRETION 5 200 0.000595 0.004591
603 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 5 200 0.000595 0.004591
604 POSITIVE REGULATION OF FIBROBLAST MIGRATION 2 11 0.0006142 0.004685
605 ENDOCARDIUM DEVELOPMENT 2 11 0.0006142 0.004685
606 REGULATION OF EXTRACELLULAR MATRIX ASSEMBLY 2 11 0.0006142 0.004685
607 REGULATION OF REMOVAL OF SUPEROXIDE RADICALS 2 11 0.0006142 0.004685
608 LYMPHANGIOGENESIS 2 11 0.0006142 0.004685
609 NEGATIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 2 11 0.0006142 0.004685
610 REGULATION OF ODONTOGENESIS OF DENTIN CONTAINING TOOTH 2 11 0.0006142 0.004685
611 NEGATIVE REGULATION OF PEPTIDE SECRETION 3 49 0.0006192 0.004708
612 REGULATION OF STEROID BIOSYNTHETIC PROCESS 3 49 0.0006192 0.004708
613 CELLULAR RESPONSE TO ALCOHOL 4 115 0.0006362 0.004829
614 FACE DEVELOPMENT 3 50 0.0006572 0.00498
615 NEURON PROJECTION GUIDANCE 5 205 0.0006653 0.005033
616 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 7 437 0.0006969 0.005238
617 ARTERY MORPHOGENESIS 3 51 0.0006966 0.005238
618 PROTEIN MONOUBIQUITINATION 3 51 0.0006966 0.005238
619 POSITIVE REGULATION OF MAP KINASE ACTIVITY 5 207 0.000695 0.005238
620 POSITIVE REGULATION OF HORMONE SECRETION 4 119 0.0007234 0.005429
621 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 5 209 0.0007258 0.005438
622 POSITIVE REGULATION OF REPRODUCTIVE PROCESS 3 52 0.0007374 0.005455
623 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.0007354 0.005455
624 POSITIVE REGULATION OF DNA DEPENDENT DNA REPLICATION 2 12 0.0007354 0.005455
625 HEART FORMATION 2 12 0.0007354 0.005455
626 TRACHEA MORPHOGENESIS 2 12 0.0007354 0.005455
627 GROWTH PLATE CARTILAGE DEVELOPMENT 2 12 0.0007354 0.005455
628 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 52 0.0007374 0.005455
629 POSITIVE REGULATION OF ASTROCYTE DIFFERENTIATION 2 12 0.0007354 0.005455
630 RESPONSE TO ACID CHEMICAL 6 319 0.0007494 0.005534
631 REGULATION OF PROTEIN KINASE B SIGNALING 4 121 0.00077 0.005669
632 NEGATIVE REGULATION OF IMMUNE RESPONSE 4 121 0.00077 0.005669
633 NEGATIVE REGULATION OF EPITHELIAL CELL MIGRATION 3 53 0.0007798 0.005732
634 MULTI MULTICELLULAR ORGANISM PROCESS 5 213 0.0007904 0.005801
635 REGULATION OF CATABOLIC PROCESS 9 731 0.0007934 0.005814
636 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0008236 0.006016
637 CARDIAC MUSCLE TISSUE MORPHOGENESIS 3 54 0.0008236 0.006016
638 TYPE B PANCREATIC CELL DEVELOPMENT 2 13 0.0008672 0.006246
639 POSITIVE REGULATION OF STEROID BIOSYNTHETIC PROCESS 2 13 0.0008672 0.006246
640 BEHAVIORAL RESPONSE TO PAIN 2 13 0.0008672 0.006246
641 LEUKOCYTE TETHERING OR ROLLING 2 13 0.0008672 0.006246
642 LEUKOCYTE ADHESION TO VASCULAR ENDOTHELIAL CELL 2 13 0.0008672 0.006246
643 LYMPH VESSEL MORPHOGENESIS 2 13 0.0008672 0.006246
644 TELENCEPHALON REGIONALIZATION 2 13 0.0008672 0.006246
645 MESODERMAL CELL FATE COMMITMENT 2 13 0.0008672 0.006246
646 POSITIVE REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 2 13 0.0008672 0.006246
647 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 4 126 0.0008957 0.006442
648 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 0.000916 0.006577
649 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 127 0.0009225 0.006614
650 REGULATION OF PROTEIN STABILITY 5 221 0.0009324 0.006675
651 NEGATIVE REGULATION OF HEMOPOIESIS 4 128 0.0009498 0.006789
652 TAXIS 7 464 0.0009894 0.007061
653 POSITIVE REGULATION OF P38MAPK CASCADE 2 14 0.00101 0.007128
654 REGULATION OF GLOMERULUS DEVELOPMENT 2 14 0.00101 0.007128
655 EMBRYONIC SKELETAL JOINT DEVELOPMENT 2 14 0.00101 0.007128
656 METANEPHRIC MESENCHYME DEVELOPMENT 2 14 0.00101 0.007128
657 REGULATION OF EXTRACELLULAR MATRIX DISASSEMBLY 2 14 0.00101 0.007128
658 ADENOHYPOPHYSIS DEVELOPMENT 2 14 0.00101 0.007128
659 BONE MATURATION 2 14 0.00101 0.007128
660 CELLULAR RESPONSE TO CORTICOSTEROID STIMULUS 3 58 0.001015 0.007143
661 PROTEOGLYCAN BIOSYNTHETIC PROCESS 3 58 0.001015 0.007143
662 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 4 131 0.001035 0.007266
663 RETINA DEVELOPMENT IN CAMERA TYPE EYE 4 131 0.001035 0.007266
664 POSITIVE REGULATION OF CELL DIVISION 4 132 0.001065 0.007463
665 TELENCEPHALON DEVELOPMENT 5 228 0.001072 0.007498
666 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 10 926 0.001093 0.007637
667 NEGATIVE REGULATION OF CELL DIVISION 3 60 0.00112 0.007801
668 OLIGODENDROCYTE DIFFERENTIATION 3 60 0.00112 0.007801
669 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 4 134 0.001126 0.007831
670 CELLULAR PROTEIN COMPLEX ASSEMBLY 6 346 0.00114 0.007919
671 N TERMINAL PROTEIN AMINO ACID ACETYLATION 2 15 0.001162 0.007942
672 POSITIVE REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 2 15 0.001162 0.007942
673 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 135 0.001157 0.007942
674 ENDOCARDIAL CUSHION FORMATION 2 15 0.001162 0.007942
675 REGULATION OF MESODERM DEVELOPMENT 2 15 0.001162 0.007942
676 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.001162 0.007942
677 STRIATED MUSCLE CELL PROLIFERATION 2 15 0.001162 0.007942
678 CHRONIC INFLAMMATORY RESPONSE 2 15 0.001162 0.007942
679 POSITIVE REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS 2 15 0.001162 0.007942
680 CELL GROWTH 4 135 0.001157 0.007942
681 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 5 232 0.001158 0.007942
682 ACTIVATION OF MAPK ACTIVITY 4 137 0.001222 0.008338
683 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 6 351 0.001227 0.00836
684 CELL CYCLE G2 M PHASE TRANSITION 4 138 0.001255 0.00854
685 SECRETION BY CELL 7 486 0.001293 0.008783
686 NUCLEAR TRANSPORT 6 355 0.0013 0.00882
687 REGULATION OF MONONUCLEAR CELL MIGRATION 2 16 0.001325 0.008938
688 ORGAN INDUCTION 2 16 0.001325 0.008938
689 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 2 16 0.001325 0.008938
690 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 2 16 0.001325 0.008938
691 REGULATION OF PROTEIN ACETYLATION 3 64 0.00135 0.009093
692 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 6 361 0.001416 0.009523
693 PROTEIN POLYUBIQUITINATION 5 243 0.001421 0.009527
694 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 0.001421 0.009527
695 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 0.001431 0.009584
696 CELLULAR RESPONSE TO UV 3 66 0.001476 0.009861
697 POSITIVE REGULATION OF DEFENSE RESPONSE 6 364 0.001477 0.009861
698 NEGATIVE REGULATION OF KIDNEY DEVELOPMENT 2 17 0.001499 0.009906
699 BRANCH ELONGATION OF AN EPITHELIUM 2 17 0.001499 0.009906
700 EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS 2 17 0.001499 0.009906
701 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 2 17 0.001499 0.009906
702 NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 2 17 0.001499 0.009906
703 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 2 17 0.001499 0.009906
704 RECEPTOR CATABOLIC PROCESS 2 17 0.001499 0.009906
705 NEGATIVE REGULATION OF MAPK CASCADE 4 145 0.001506 0.009943
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 21 50 2.915e-40 2.708e-37
2 SMAD BINDING 16 72 1.693e-25 7.866e-23
3 CYTOKINE RECEPTOR BINDING 22 271 7.775e-25 2.408e-22
4 RECEPTOR SIGNALING PROTEIN ACTIVITY 18 172 2.344e-22 5.444e-20
5 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE ACTIVITY 10 17 1.972e-21 3.663e-19
6 GROWTH FACTOR ACTIVITY 15 160 5.552e-18 8.596e-16
7 RECEPTOR SERINE THREONINE KINASE BINDING 8 15 7.363e-17 9.772e-15
8 CYTOKINE ACTIVITY 15 219 6.4e-16 7.432e-14
9 I SMAD BINDING 7 11 1.248e-15 1.288e-13
10 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 10 81 1.608e-13 1.468e-11
11 PROTEIN DIMERIZATION ACTIVITY 24 1149 1.738e-13 1.468e-11
12 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 10 92 5.995e-13 4.524e-11
13 RECEPTOR BINDING 26 1476 6.33e-13 4.524e-11
14 ACTIVIN BINDING 6 12 1.121e-12 7.436e-11
15 TRANSFORMING GROWTH FACTOR BETA BINDING 6 16 9.609e-12 5.951e-10
16 GROWTH FACTOR BINDING 10 123 1.149e-11 6.671e-10
17 PROTEIN SERINE THREONINE KINASE ACTIVITY 15 445 1.937e-11 1.058e-09
18 IDENTICAL PROTEIN BINDING 22 1209 3.536e-11 1.825e-09
19 TRANSCRIPTION FACTOR BINDING 15 524 1.908e-10 9.328e-09
20 CYTOKINE BINDING 8 92 8.67e-10 4.027e-08
21 PROTEIN KINASE ACTIVITY 15 640 2.96e-09 1.309e-07
22 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 19 1199 1.046e-08 4.417e-07
23 R SMAD BINDING 5 23 1.255e-08 5.07e-07
24 PROTEIN HOMODIMERIZATION ACTIVITY 15 722 1.493e-08 5.778e-07
25 GLYCOSAMINOGLYCAN BINDING 9 205 3.061e-08 1.137e-06
26 CORE PROMOTER PROXIMAL REGION DNA BINDING 11 371 4.596e-08 1.642e-06
27 CO SMAD BINDING 4 12 5.926e-08 2.039e-06
28 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 7 104 6.263e-08 2.078e-06
29 COLLAGEN BINDING 6 65 8.7e-08 2.787e-06
30 KINASE ACTIVITY 15 842 1.125e-07 3.485e-06
31 MACROMOLECULAR COMPLEX BINDING 19 1399 1.224e-07 3.668e-06
32 SIGNAL TRANSDUCER ACTIVITY 21 1731 1.495e-07 4.34e-06
33 PROTEIN COMPLEX BINDING 15 935 4.32e-07 1.216e-05
34 PROTEIN HETERODIMERIZATION ACTIVITY 11 468 4.721e-07 1.29e-05
35 REGULATORY REGION NUCLEIC ACID BINDING 14 818 5.179e-07 1.375e-05
36 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 15 992 9.122e-07 2.354e-05
37 HEPARIN BINDING 7 157 1.042e-06 2.617e-05
38 SULFUR COMPOUND BINDING 8 234 1.258e-06 2.998e-05
39 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 12 629 1.227e-06 2.998e-05
40 ACTIVATING TRANSCRIPTION FACTOR BINDING 5 57 1.428e-06 3.318e-05
41 BHLH TRANSCRIPTION FACTOR BINDING 4 28 2.353e-06 5.331e-05
42 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 4 36 6.631e-06 0.0001467
43 DOUBLE STRANDED DNA BINDING 12 764 9.028e-06 0.0001951
44 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 8 328 1.51e-05 0.0003188
45 GLYCOPROTEIN BINDING 5 101 2.408e-05 0.0004971
46 UBIQUITIN LIKE PROTEIN LIGASE BINDING 7 264 3.146e-05 0.0006354
47 ENZYME BINDING 17 1737 5.2e-05 0.001028
48 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 7 315 9.578e-05 0.001854
49 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 6 226 0.0001189 0.002254
50 SEQUENCE SPECIFIC DNA BINDING 12 1037 0.000175 0.003252
51 BETA CATENIN BINDING 4 84 0.0001922 0.0035
52 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 4 101 0.0003894 0.006956
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR COMPLEX 16 298 2.89e-15 1.688e-12
2 EXTRACELLULAR SPACE 20 1376 1.665e-08 4.861e-06
3 RECEPTOR COMPLEX 10 327 1.494e-07 2.909e-05
4 EXTRACELLULAR MATRIX 10 426 1.67e-06 0.0002438
5 PLASMA MEMBRANE RECEPTOR COMPLEX 7 175 2.154e-06 0.0002516
6 PLATELET ALPHA GRANULE 5 75 5.617e-06 0.0005467
7 PLATELET ALPHA GRANULE LUMEN 4 55 3.658e-05 0.003051
8 CELL SURFACE 11 757 4.546e-05 0.003213
9 MEMBRANE MICRODOMAIN 7 288 5.463e-05 0.003213
10 PLASMA MEMBRANE PROTEIN COMPLEX 9 510 5.501e-05 0.003213
11 TRANSFERASE COMPLEX 10 703 0.0001245 0.006608
12 CATALYTIC COMPLEX 12 1038 0.0001766 0.008594
13 SECRETORY GRANULE LUMEN 4 85 0.0002011 0.008701
14 SCF UBIQUITIN LIGASE COMPLEX 3 34 0.0002086 0.008701
15 PROTEIN KINASE COMPLEX 4 90 0.0002506 0.009757

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04350_TGF.beta_signaling_pathway 68 85 3.008e-179 5.414e-177
2 hsa04390_Hippo_signaling_pathway 27 154 4.114e-40 3.702e-38
3 hsa04110_Cell_cycle 18 128 9.15e-25 5.49e-23
4 hsa04310_Wnt_signaling_pathway 14 151 9.193e-17 4.137e-15
5 hsa04144_Endocytosis 12 203 3.819e-12 1.375e-10
6 hsa04520_Adherens_junction 7 73 5.219e-09 1.566e-07
7 hsa04151_PI3K_AKT_signaling_pathway 11 351 2.611e-08 6.714e-07
8 hsa04340_Hedgehog_signaling_pathway 6 56 3.503e-08 7.881e-07
9 hsa04114_Oocyte_meiosis 6 114 2.466e-06 4.932e-05
10 hsa04010_MAPK_signaling_pathway 7 268 3.463e-05 0.0006233
11 hsa04510_Focal_adhesion 6 200 6.064e-05 0.0009511
12 hsa04710_Circadian_rhythm_._mammal 3 23 6.341e-05 0.0009511
13 hsa04380_Osteoclast_differentiation 5 128 7.493e-05 0.001038
14 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.0001106 0.001423
15 hsa04512_ECM.receptor_interaction 4 85 0.0002011 0.002414
16 hsa04730_Long.term_depression 3 70 0.001749 0.01967
17 hsa04145_Phagosome 4 156 0.001969 0.02084
18 hsa03015_mRNA_surveillance_pathway 3 83 0.002844 0.02844
19 hsa04012_ErbB_signaling_pathway 3 87 0.003249 0.03078
20 hsa04530_Tight_junction 3 133 0.01052 0.09467
21 hsa04330_Notch_signaling_pathway 2 47 0.01116 0.09563
22 hsa04150_mTOR_signaling_pathway 2 52 0.01354 0.1108
23 hsa04630_Jak.STAT_signaling_pathway 3 155 0.01585 0.124
24 hsa04141_Protein_processing_in_endoplasmic_reticulum 3 168 0.01959 0.1469
25 hsa04720_Long.term_potentiation 2 70 0.02371 0.1707
26 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.04153 0.2875
27 hsa04916_Melanogenesis 2 101 0.04637 0.3092
28 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.05931 0.3737
29 hsa04670_Leukocyte_transendothelial_migration 2 117 0.06021 0.3737
30 hsa04360_Axon_guidance 2 130 0.07236 0.4342
31 hsa04910_Insulin_signaling_pathway 2 138 0.0802 0.4657
32 hsa04062_Chemokine_signaling_pathway 2 189 0.1353 0.7612
33 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.1648 0.8473

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 DHRS4-AS1 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-29a-5p;hsa-miR-301a-3p;hsa-miR-769-5p;hsa-miR-877-5p;hsa-miR-93-3p 12 BMPR2 Sponge network -0.646 0.01829 -0.736 0 0.493
2

HCG11

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-501-3p;hsa-miR-93-5p 11 TGFBR2 Sponge network -0.781 0 -0.523 3.0E-5 0.472
3

HCG11

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-455-5p;hsa-miR-618;hsa-miR-877-5p;hsa-miR-93-5p 16 BMPR2 Sponge network -0.781 0 -0.736 0 0.47
4 RP11-517P14.2 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29a-5p;hsa-miR-301a-3p;hsa-miR-769-5p;hsa-miR-93-5p 10 BMPR2 Sponge network -0.191 0.49845 -0.736 0 0.436
5

MAGI2-AS3

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-454-3p;hsa-miR-92a-3p;hsa-miR-93-5p 12 TGFBR2 Sponge network -1.801 0 -0.523 3.0E-5 0.428
6

MAGI2-AS3

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-30d-5p;hsa-miR-362-3p;hsa-miR-455-5p;hsa-miR-532-5p;hsa-miR-671-5p;hsa-miR-769-5p;hsa-miR-877-5p;hsa-miR-92a-3p;hsa-miR-93-3p;hsa-miR-93-5p 20 BMPR2 Sponge network -1.801 0 -0.736 0 0.408
7 DNM3OS hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-5p;hsa-miR-618;hsa-miR-93-3p;hsa-miR-93-5p 13 BMPR2 Sponge network -2.094 1.0E-5 -0.736 0 0.382
8

RP11-12A2.3

 hsa-miR-106b-5p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-30d-5p;hsa-miR-671-5p;hsa-miR-877-5p;hsa-miR-92a-3p;hsa-miR-93-3p;hsa-miR-93-5p 16 BMPR2 Sponge network -4.779 0 -0.736 0 0.362
9 LINC00924 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-877-5p;hsa-miR-93-5p 11 BMPR2 Sponge network -0.391 0.1281 -0.736 0 0.357
10 SOCS2-AS1 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-532-5p;hsa-miR-671-5p;hsa-miR-93-3p;hsa-miR-93-5p 13 BMPR2 Sponge network -0.984 3.0E-5 -0.736 0 0.355
11

RP11-166D19.1

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-532-5p;hsa-miR-590-5p;hsa-miR-618;hsa-miR-877-5p;hsa-miR-92a-3p;hsa-miR-93-3p 17 BMPR2 Sponge network -0.244 0.28835 -0.736 0 0.348
12

RP11-685F15.1

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-93-5p 11 BMPR2 Sponge network -9.951 0 -0.736 0 0.34
13

CASC2

 hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-362-3p;hsa-miR-532-5p;hsa-miR-618;hsa-miR-877-5p;hsa-miR-92a-3p;hsa-miR-93-5p 15 BMPR2 Sponge network -0.596 0.00187 -0.736 0 0.327
14

RP11-166D19.1

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-590-5p;hsa-miR-92a-3p 11 TGFBR2 Sponge network -0.244 0.28835 -0.523 3.0E-5 0.324
15 LINC00885 hsa-miR-106b-5p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-19a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-29a-5p;hsa-miR-877-5p 10 BMPR2 Sponge network -4.686 0 -0.736 0 0.314
16 RP11-250B2.6 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-30d-5p;hsa-miR-93-5p 10 BMPR2 Sponge network -0.98 2.0E-5 -0.736 0 0.272
17 RP11-1018N14.5 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-29a-5p;hsa-miR-301a-3p;hsa-miR-455-5p;hsa-miR-769-5p;hsa-miR-93-5p 12 BMPR2 Sponge network -0.573 0.20573 -0.736 0 0.27
18

LDLRAD4-AS1

 hsa-miR-106b-5p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-671-5p;hsa-miR-93-3p;hsa-miR-93-5p 12 BMPR2 Sponge network -3.366 0 -0.736 0 0.263
19

RP11-166D19.1

 hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-32-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-616-5p;hsa-miR-618;hsa-miR-92a-3p 11 THBS1 Sponge network -0.244 0.28835 -2.167 0 0.257
20

RP11-685F15.1

 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-454-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -9.951 0 -0.523 3.0E-5 0.254

Quest ID: de0d459a9f61b221a321637ac52d58f5