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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-15a-5p ACSL4 0.01 0.57141 0.66 0.00114 MirTarget; miRNATAP -1.42 0.01374 NA
2 hsa-miR-15a-5p ACVR2A 0.01 0.57141 -0.17 0.00276 MirTarget; miRNATAP -0.49 0.00283 NA
3 hsa-miR-15a-5p ADAMTS5 0.01 0.57141 -0.31 0.00979 miRNATAP -1.09 0.00103 NA
4 hsa-miR-15a-5p ADCY1 0.01 0.57141 0.12 0.37601 mirMAP -1.27 0.00049 NA
5 hsa-miR-15a-5p ADCY5 0.01 0.57141 -0.52 2.0E-5 MirTarget; miRNATAP -1.66 0 NA
6 hsa-miR-15a-5p ADGRD1 0.01 0.57141 -0.17 0.42537 MirTarget -3.61 0 NA
7 hsa-miR-15a-5p ADGRL2 0.01 0.57141 -0.73 0 MirTarget; miRNATAP -1.01 0.00949 NA
8 hsa-miR-15a-5p AHRR 0.01 0.57141 0.04 0.54652 mirMAP -0.42 0.01078 NA
9 hsa-miR-15a-5p AKT3 0.01 0.57141 -0.32 0.00594 miRNAWalker2 validate; miRTarBase; miRNATAP -0.89 0.00617 NA
10 hsa-miR-126-5p ALCAM 0 0.93995 0.26 0.00012 mirMAP; miRNATAP -0.54 0.01139 NA
11 hsa-miR-142-5p ALCAM -0.12 0.00783 0.26 0.00012 MirTarget; PITA; mirMAP; miRNATAP -0.25 0.02509 NA
12 hsa-miR-148a-3p ALCAM -0.01 0.73806 0.26 0.00012 MirTarget -0.39 0.00086 NA
13 hsa-miR-150-5p ALCAM -0.18 0.00075 0.26 0.00012 miRNATAP -0.38 3.0E-5 NA
14 hsa-miR-152-3p ALCAM -0 0.97674 0.26 0.00012 MirTarget -0.34 0.02225 NA
15 hsa-miR-199a-5p ALCAM -0.44 0 0.26 0.00012 miRanda -0.38 0 NA
16 hsa-miR-199b-5p ALCAM -0.22 0.00068 0.26 0.00012 miRanda -0.21 0.00438 NA
17 hsa-miR-223-3p ALCAM -0.15 0.00045 0.26 0.00012 MirTarget -0.31 0.00612 NA
18 hsa-miR-15a-5p ANK2 0.01 0.57141 -0.79 2.0E-5 MirTarget; miRNATAP -2.09 6.0E-5 NA
19 hsa-miR-15a-5p ANKS1A 0.01 0.57141 -0.37 0 MirTarget -0.59 0.0032 NA
20 hsa-miR-15a-5p ARHGAP20 0.01 0.57141 -0.69 6.0E-5 MirTarget; miRNATAP -2.07 2.0E-5 NA
21 hsa-miR-15a-5p ARL2 0.01 0.57141 0.2 0.0061 MirTarget; miRNATAP -0.79 8.0E-5 NA
22 hsa-miR-15a-5p ARMCX2 0.01 0.57141 -0.59 0 MirTarget; miRNATAP -1.3 0.00015 NA
23 hsa-miR-15a-5p ASB1 0.01 0.57141 0.05 0.5086 MirTarget; miRNATAP -0.6 0.00566 NA
24 hsa-miR-15a-5p ASTN1 0.01 0.57141 -0.43 5.0E-5 MirTarget -0.68 0.0248 NA
25 hsa-miR-15a-5p BAG5 0.01 0.57141 0.01 0.7689 miRNATAP -0.23 0.03793 NA
26 hsa-miR-15a-5p BCL11B 0.01 0.57141 -0.7 0.0001 MirTarget -1.28 0.01211 NA
27 hsa-miR-15a-5p BRSK2 0.01 0.57141 0.27 0.0036 mirMAP -0.86 0.00086 NA
28 hsa-miR-15a-5p BTG2 0.01 0.57141 -0.27 0.03814 MirTarget; miRNATAP -0.77 0.03312 NA
29 hsa-miR-15a-5p BVES 0.01 0.57141 -0.09 0.34596 MirTarget -1.26 0 NA
30 hsa-miR-15a-5p C8orf58 0.01 0.57141 -0.19 0.02594 miRNATAP -0.63 0.01023 NA
31 hsa-miR-141-3p CADM1 -0.14 0.00512 0.01 0.91974 MirTarget; TargetScan -0.63 0.0007 NA
32 hsa-miR-142-5p CADM1 -0.12 0.00783 0.01 0.91974 PITA -0.65 0.00307 NA
33 hsa-miR-182-3p CADM1 0.08 0.03587 0.01 0.91974 MirTarget; miRNATAP -0.58 0.03482 24445397 TGF β upregulates miR 182 expression to promote gallbladder cancer metastasis by targeting CADM1; We further identified that the cell adhesion molecule1 CADM1 is a new target gene of miR-182 miR-182 negatively regulates CADM1 expression in vitro and in vivo
34 hsa-miR-199b-5p CADM1 -0.22 0.00068 0.01 0.91974 PITA; miRanda -0.47 0.00135 NA
35 hsa-miR-34c-5p CADM1 0.2 5.0E-5 0.01 0.91974 miRanda -0.59 0.00234 NA
36 hsa-miR-92a-3p CADM1 -0.03 0.37888 0.01 0.91974 miRNATAP -1.87 0 NA
37 hsa-miR-107 CADM3 0.13 0 -0.1 0.01289 miRanda -0.28 0.00674 NA
38 hsa-miR-324-3p CADM3 0.02 0.24561 -0.1 0.01289 MirTarget -0.46 0.00346 NA
39 hsa-miR-330-3p CADM3 0.05 0.00086 -0.1 0.01289 mirMAP; miRNATAP -0.53 0.01298 NA
40 hsa-miR-331-3p CADM3 0.14 0 -0.1 0.01289 MirTarget; mirMAP -0.36 0.00148 NA
41 hsa-miR-346 CADM3 0.09 1.0E-5 -0.1 0.01289 miRanda; miRNATAP -0.32 0.0304 NA
42 hsa-miR-15a-5p CALM1 0.01 0.57141 -0.13 0.00385 miRNATAP -0.61 0 NA
43 hsa-miR-15a-5p CCNJL 0.01 0.57141 -0.47 0.00012 miRNATAP -1.04 0.00256 NA
44 hsa-miR-15a-5p CCNYL1 0.01 0.57141 0.04 0.59551 miRNAWalker2 validate -0.52 0.02602 NA
45 hsa-miR-15a-5p CD164 0.01 0.57141 -0.41 0 MirTarget; miRNATAP -0.52 0.03639 NA
46 hsa-miR-140-5p CD226 0.04 0.1479 -0.77 0 miRanda -0.82 0.00924 NA
47 hsa-miR-17-5p CD226 0.06 0.05778 -0.77 0 TargetScan -1.31 0 NA
48 hsa-miR-182-5p CD226 0.14 0.00166 -0.77 0 MirTarget -1.35 0 NA
49 hsa-miR-211-5p CD226 0.09 0.01154 -0.77 0 MirTarget -0.65 0.01589 NA
50 hsa-miR-217 CD226 0.09 0.11729 -0.77 0 miRanda -0.38 0.02038 NA
51 hsa-miR-331-3p CD226 0.14 0 -0.77 0 miRNATAP -2.43 0 NA
52 hsa-miR-422a CD226 0.04 0.07853 -0.77 0 MirTarget; miRanda -1.36 0.00017 NA
53 hsa-miR-448 CD226 0.03 0.16644 -0.77 0 miRanda -1.39 0.00113 NA
54 hsa-miR-103a-3p CD274 0.11 0 -0.74 0 miRNAWalker2 validate -2.21 0 NA
55 hsa-miR-106a-5p CD274 0.05 0.12421 -0.74 0 MirTarget; miRNATAP -1.21 0.00039 NA
56 hsa-miR-106b-5p CD274 0.17 0 -0.74 0 MirTarget; miRNATAP -2.78 0 NA
57 hsa-miR-107 CD274 0.13 0 -0.74 0 miRanda -1.95 0 NA
58 hsa-miR-137 CD274 0.03 0.28838 -0.74 0 miRanda -0.87 0.02966 NA
59 hsa-miR-140-5p CD274 0.04 0.1479 -0.74 0 miRanda -0.84 0.03715 NA
60 hsa-miR-15b-5p CD274 0.17 0 -0.74 0 MirTarget -1.48 2.0E-5 NA
61 hsa-miR-17-5p CD274 0.06 0.05778 -0.74 0 MirTarget; TargetScan; miRNATAP -1.43 0.0001 NA
62 hsa-miR-182-5p CD274 0.14 0.00166 -0.74 0 mirMAP -0.84 0.00144 NA
63 hsa-miR-20a-5p CD274 -0.02 0.56346 -0.74 0 MirTarget; miRNATAP -0.99 0.00635 NA
64 hsa-miR-302c-5p CD274 0.09 0.0137 -0.74 0 MirTarget -1.84 0 NA
65 hsa-miR-324-5p CD274 0.23 0 -0.74 0 miRanda -1.66 0 NA
66 hsa-miR-339-5p CD274 0.14 0 -0.74 0 miRanda -2.1 0 NA
67 hsa-miR-93-5p CD274 0.19 0 -0.74 0 MirTarget; miRNATAP -2.38 0 NA
68 hsa-let-7a-5p CD276 -0.03 0.25442 -0.01 0.89577 miRNAWalker2 validate -0.5 0.01745 NA
69 hsa-miR-28-5p CD276 0.01 0.57396 -0.01 0.89577 miRNAWalker2 validate; miRanda -0.81 0.02525 NA
70 hsa-miR-29a-3p CD276 -0.02 0.42365 -0.01 0.89577 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -1.05 0 NA
71 hsa-miR-29b-3p CD276 0.03 0.47094 -0.01 0.89577 MirTarget; miRNATAP -0.82 0 NA
72 hsa-miR-29c-3p CD276 -0.12 0.01035 -0.01 0.89577 MirTarget; miRNATAP -0.67 0 24577056 Identifying microRNAs regulating B7 H3 in breast cancer: the clinical impact of microRNA 29c
73 hsa-miR-335-5p CD276 0.02 0.79934 -0.01 0.89577 miRNAWalker2 validate -0.15 0.03377 NA
74 hsa-miR-448 CD276 0.03 0.16644 -0.01 0.89577 miRNATAP -0.69 0.00847 NA
75 hsa-miR-449a CD276 0.03 0.11286 -0.01 0.89577 mirMAP -0.62 0.02052 NA
76 hsa-miR-15a-5p CD3E 0.01 0.57141 -0.63 0.00056 MirTarget -1.03 0.04802 NA
77 hsa-miR-15a-5p CD80 0.01 0.57141 -0.47 0.00188 MirTarget -1 0.02025 NA
78 hsa-miR-15a-5p CDC42EP2 0.01 0.57141 -0.21 0.00054 miRNATAP -0.54 0.00136 NA
79 hsa-miR-129-5p CDH2 -0.01 0.79472 -0.09 0.08311 miRanda; miRNATAP -0.26 0.02505 NA
80 hsa-miR-155-5p CDH2 0.04 0.14794 -0.09 0.08311 miRNAWalker2 validate -0.3 0.01004 NA
81 hsa-miR-206 CDH2 0.03 0.13251 -0.09 0.08311 miRanda -0.65 8.0E-5 NA
82 hsa-miR-185-5p CDH4 0.11 0 -0.51 1.0E-5 MirTarget -1.37 0.00017 NA
83 hsa-miR-34c-5p CDH4 0.2 5.0E-5 -0.51 1.0E-5 miRanda -1.02 0 NA
84 hsa-miR-107 CDH5 0.13 0 -0.41 1.0E-5 miRanda -0.78 0.00097 NA
85 hsa-miR-128-3p CDH5 0.08 0.0018 -0.41 1.0E-5 miRNAWalker2 validate -1.21 0 NA
86 hsa-miR-335-5p CDH5 0.02 0.79934 -0.41 1.0E-5 miRNAWalker2 validate -0.4 1.0E-5 NA
87 hsa-miR-15a-5p CECR6 0.01 0.57141 0.12 0.15753 MirTarget; miRNATAP -0.58 0.01123 NA
88 hsa-miR-186-5p CLDN11 0.12 0 -1.02 7.0E-5 mirMAP -2.97 0.00012 NA
89 hsa-miR-217 CLDN11 0.09 0.11729 -1.02 7.0E-5 miRanda -0.97 0.00363 NA
90 hsa-miR-221-3p CLDN11 0.19 0 -1.02 7.0E-5 MirTarget -1.34 0.00217 NA
91 hsa-miR-222-3p CLDN11 0.15 3.0E-5 -1.02 7.0E-5 MirTarget -1.3 0.00867 NA
92 hsa-miR-25-3p CLDN11 0.11 0 -1.02 7.0E-5 MirTarget -5.17 0 NA
93 hsa-miR-32-5p CLDN11 0.16 0 -1.02 7.0E-5 MirTarget -2.95 0 NA
94 hsa-miR-331-3p CLDN11 0.14 0 -1.02 7.0E-5 PITA -3.63 0 NA
95 hsa-miR-346 CLDN11 0.09 1.0E-5 -1.02 7.0E-5 MirTarget; miRanda -6.81 0 NA
96 hsa-miR-365a-3p CLDN11 0.1 0.00092 -1.02 7.0E-5 MirTarget -2.01 0.00076 NA
97 hsa-miR-367-3p CLDN11 0.08 0.00094 -1.02 7.0E-5 MirTarget -3.26 1.0E-5 NA
98 hsa-miR-448 CLDN11 0.03 0.16644 -1.02 7.0E-5 miRanda -3.43 0.0001 NA
99 hsa-miR-92a-3p CLDN11 -0.03 0.37888 -1.02 7.0E-5 MirTarget -1.59 0.01732 NA
100 hsa-miR-125a-5p CLDN16 -0.13 0.00014 0.06 0.37863 miRanda -0.33 0.01625 NA
101 hsa-miR-186-5p CLDN18 0.12 0 0.05 0.35128 MirTarget -0.43 0.01307 NA
102 hsa-miR-30e-3p CLDN18 -0.08 0.0159 0.05 0.35128 mirMAP -0.29 0.02966 NA
103 hsa-miR-125a-5p CLDN19 -0.13 0.00014 0.11 0.07529 mirMAP -0.31 0.01478 NA
104 hsa-miR-125b-5p CLDN19 -0.19 1.0E-5 0.11 0.07529 mirMAP -0.29 0.00409 NA
105 hsa-miR-195-5p CLDN19 -0.18 1.0E-5 0.11 0.07529 mirMAP -0.43 3.0E-5 NA
106 hsa-miR-214-3p CLDN19 -0.32 0 0.11 0.07529 mirMAP -0.33 5.0E-5 NA
107 hsa-miR-424-5p CLDN19 -0.16 0 0.11 0.07529 mirMAP -0.41 0.00229 NA
108 hsa-miR-142-3p CLDN20 -0.06 0.14584 0.02 0.55738 miRanda -0.18 0.00237 NA
109 hsa-miR-199b-5p CLDN22 -0.22 0.00068 -0 0.99119 miRanda -0.1 0.02081 NA
110 hsa-miR-218-5p CLDN23 -0.14 0.00268 0.05 0.55692 MirTarget -0.31 0.01512 NA
111 hsa-miR-222-3p CLDN23 0.15 3.0E-5 0.05 0.55692 miRNAWalker2 validate -0.41 0.00774 NA
112 hsa-miR-129-5p CLDN3 -0.01 0.79472 -0.12 0.0706 MirTarget -0.39 0.01539 NA
113 hsa-miR-139-5p CLDN4 -0.08 0.00239 -0.38 0.0378 miRanda -1.31 0.01495 NA
114 hsa-miR-128-3p CLDN5 0.08 0.0018 -0.2 0.08862 miRNAWalker2 validate -0.9 0.0071 NA
115 hsa-miR-15a-5p CNN1 0.01 0.57141 -0.07 0.52402 miRNATAP -0.86 0.00868 NA
116 hsa-miR-32-5p CNTN1 0.16 0 -0.09 0.27962 miRNATAP -0.37 0.029 NA
117 hsa-miR-324-5p CNTN1 0.23 0 -0.09 0.27962 miRanda -0.29 0.03174 NA
118 hsa-miR-33a-5p CNTN1 0.16 0 -0.09 0.27962 MirTarget; miRNATAP -0.43 0.01667 NA
119 hsa-miR-369-3p CNTN1 0.06 0.0174 -0.09 0.27962 mirMAP -0.47 0.03585 NA
120 hsa-miR-138-5p CNTN2 -0.21 0.00013 -0.02 0.53811 mirMAP -0.14 0.00193 NA
121 hsa-miR-150-5p CNTN2 -0.18 0.00075 -0.02 0.53811 mirMAP -0.12 0.01264 NA
122 hsa-miR-205-5p CNTN2 0.01 0.71055 -0.02 0.53811 mirMAP -0.19 0.02556 NA
123 hsa-miR-195-5p CNTNAP1 -0.18 1.0E-5 0.57 2.0E-5 MirTarget -1.08 0 NA
124 hsa-miR-214-3p CNTNAP1 -0.32 0 0.57 2.0E-5 MirTarget -0.38 0.04452 NA
125 hsa-miR-424-5p CNTNAP1 -0.16 0 0.57 2.0E-5 MirTarget -1.07 0.00038 NA
126 hsa-miR-448 CNTNAP1 0.03 0.16644 0.57 2.0E-5 MirTarget; miRanda; miRNATAP -1.7 0.00026 NA
127 hsa-miR-449a CNTNAP1 0.03 0.11286 0.57 2.0E-5 MirTarget; PITA; miRanda; miRNATAP -1.34 0.00454 NA
128 hsa-miR-211-5p CNTNAP2 0.09 0.01154 -0.13 0.52501 miRNATAP -0.83 0.04927 NA
129 hsa-miR-330-3p CNTNAP2 0.05 0.00086 -0.13 0.52501 mirMAP -2.65 0.00988 NA
130 hsa-miR-34c-5p CNTNAP2 0.2 5.0E-5 -0.13 0.52501 PITA; miRanda; miRNATAP -0.7 0.01303 NA
131 hsa-miR-15a-5p COL12A1 0.01 0.57141 -0.32 0.02386 MirTarget; miRNATAP -1.36 0.00058 NA
132 hsa-miR-15a-5p COMT 0.01 0.57141 -0.61 0 MirTarget -0.82 0.01531 NA
133 hsa-miR-15a-5p CREB5 0.01 0.57141 -0.08 0.5143 miRNATAP -0.67 0.04607 NA
134 hsa-miR-449a CTLA4 0.03 0.11286 -0.18 0.37956 miRanda -3.65 0 NA
135 hsa-miR-15a-5p CYP26B1 0.01 0.57141 -0.29 0.08677 MirTarget; miRNATAP -1.48 0.00175 NA
136 hsa-miR-15a-5p CYS1 0.01 0.57141 -1.3 0 mirMAP -2.35 3.0E-5 NA
137 hsa-miR-15a-5p DBH 0.01 0.57141 -2.08 0 mirMAP -1.94 0.01347 NA
138 hsa-miR-15a-5p DENND2C 0.01 0.57141 -0.78 0 MirTarget -0.82 0.03035 NA
139 hsa-miR-15a-5p DLK1 0.01 0.57141 -0.13 0.75273 miRNAWalker2 validate -5.61 0 NA
140 hsa-miR-15a-5p EDA 0.01 0.57141 -0.07 0.50152 MirTarget; miRNATAP -0.74 0.01184 NA
141 hsa-miR-15a-5p EIF4B 0.01 0.57141 0.04 0.51431 miRNATAP -0.61 0.00078 NA
142 hsa-miR-15a-5p ELL 0.01 0.57141 -0.01 0.86744 MirTarget; miRNATAP -0.33 0.02568 NA
143 hsa-miR-15a-5p EPB41L1 0.01 0.57141 -0.04 0.81245 MirTarget -1.11 0.01005 NA
144 hsa-miR-15a-5p EPHA1 0.01 0.57141 0.16 0.32601 miRNATAP -1.06 0.0209 NA
145 hsa-miR-15a-5p EYA4 0.01 0.57141 -0.05 0.19647 MirTarget -0.23 0.03713 NA
146 hsa-miR-181a-5p F11R -0.02 0.5042 0.08 0.44822 mirMAP -0.65 0.02062 NA
147 hsa-miR-335-5p F11R 0.02 0.79934 0.08 0.44822 miRNAWalker2 validate -0.24 0.01205 NA
148 hsa-miR-15a-5p FAT4 0.01 0.57141 -0.98 0 MirTarget -0.97 0.03663 NA
149 hsa-miR-15a-5p FCHSD1 0.01 0.57141 -0.1 0.18807 MirTarget; miRNATAP -0.75 0.00037 NA
150 hsa-miR-15a-5p FCHSD2 0.01 0.57141 -0.32 0 miRNATAP -0.78 4.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 BIOLOGICAL ADHESION 78 1032 1.155e-43 5.373e-40
2 CELL CELL ADHESION 56 608 3.364e-35 7.827e-32
3 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 28 204 1.938e-22 3.006e-19
4 SINGLE ORGANISM CELL ADHESION 36 459 3.142e-20 3.655e-17
5 LOCOMOTION 49 1114 1.026e-16 9.545e-14
6 POSITIVE REGULATION OF CELL CELL ADHESION 24 243 5.091e-16 3.948e-13
7 HETEROPHILIC CELL CELL ADHESION VIA PLASMA MEMBRANE CELL ADHESION MOLECULES 13 45 1.734e-15 1.153e-12
8 POSITIVE REGULATION OF CELL ADHESION 28 376 2.496e-15 1.452e-12
9 REGULATION OF CELL ADHESION 35 629 4.828e-15 2.496e-12
10 CALCIUM INDEPENDENT CELL CELL ADHESION VIA PLASMA MEMBRANE CELL ADHESION MOLECULES 10 21 8.412e-15 3.914e-12
11 REGULATION OF CELL CELL ADHESION 27 380 2.556e-14 1.081e-11
12 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 48 1275 8.482e-14 3.289e-11
13 REGULATION OF HOMOTYPIC CELL CELL ADHESION 24 307 9.569e-14 3.425e-11
14 LYMPHOCYTE COSTIMULATION 14 78 1.878e-13 6.243e-11
15 CELL MOTILITY 37 835 8.156e-13 2.372e-10
16 LOCALIZATION OF CELL 37 835 8.156e-13 2.372e-10
17 CELL DEVELOPMENT 49 1426 1.331e-12 3.643e-10
18 CELL JUNCTION ORGANIZATION 18 185 3.436e-12 8.882e-10
19 NEURON PROJECTION DEVELOPMENT 28 545 2.184e-11 5.348e-09
20 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 27 513 2.966e-11 6.901e-09
21 NEURON DEVELOPMENT 31 687 4.56e-11 1.01e-08
22 POSITIVE REGULATION OF T CELL PROLIFERATION 13 95 5.054e-11 1.069e-08
23 POSITIVE REGULATION OF CELL ACTIVATION 21 311 5.782e-11 1.17e-08
24 REGULATION OF T CELL PROLIFERATION 15 147 1.167e-10 2.262e-08
25 REGULATION OF CELL ACTIVATION 25 484 2.5e-10 4.653e-08
26 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 11 70 3.457e-10 6.187e-08
27 NEUROGENESIS 44 1402 4.322e-10 7.448e-08
28 CELL SUBSTRATE ADHESION 15 164 5.508e-10 9.154e-08
29 LEUKOCYTE MIGRATION 18 259 9.054e-10 1.453e-07
30 NEURON DIFFERENTIATION 33 874 1.025e-09 1.59e-07
31 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 48 1672 1.167e-09 1.751e-07
32 REGULATION OF IMMUNE SYSTEM PROCESS 43 1403 1.464e-09 2.129e-07
33 REGULATION OF LEUKOCYTE PROLIFERATION 16 206 1.616e-09 2.279e-07
34 CELL PROJECTION ORGANIZATION 33 902 2.256e-09 3.087e-07
35 REGULATION OF CELL DIFFERENTIATION 44 1492 2.967e-09 3.945e-07
36 IMMUNE SYSTEM PROCESS 52 1984 4.77e-09 5.998e-07
37 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 13 136 4.671e-09 5.998e-07
38 CELLULAR COMPONENT MORPHOGENESIS 32 900 8.051e-09 9.858e-07
39 CELL MATRIX ADHESION 12 119 1.009e-08 1.185e-06
40 CELL CELL JUNCTION ASSEMBLY 10 74 1.019e-08 1.185e-06
41 CELL JUNCTION ASSEMBLY 12 129 2.52e-08 2.86e-06
42 LEUKOCYTE CELL CELL ADHESION 16 255 3.399e-08 3.766e-06
43 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 30 867 4.536e-08 4.908e-06
44 EXTRACELLULAR STRUCTURE ORGANIZATION 17 304 6.754e-08 7.142e-06
45 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 39 1395 1.137e-07 1.176e-05
46 CELLULAR RESPONSE TO INTERFERON GAMMA 11 122 1.344e-07 1.36e-05
47 TRANSMISSION OF NERVE IMPULSE 8 54 1.51e-07 1.495e-05
48 NEURON PROJECTION MORPHOGENESIS 19 402 1.586e-07 1.538e-05
49 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 12 153 1.678e-07 1.593e-05
50 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 34 1142 1.963e-07 1.827e-05
51 HETEROTYPIC CELL CELL ADHESION 6 27 4.607e-07 4.204e-05
52 RESPONSE TO INTERFERON GAMMA 11 144 7.214e-07 6.455e-05
53 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN 12 177 8.092e-07 7.104e-05
54 ANTIGEN PROCESSING AND PRESENTATION 13 213 9.262e-07 7.981e-05
55 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 17 368 9.99e-07 8.451e-05
56 MULTICELLULAR ORGANISMAL SIGNALING 10 123 1.317e-06 0.0001094
57 TAXIS 19 464 1.388e-06 0.0001133
58 NEGATIVE REGULATION OF CELL ADHESION 13 223 1.55e-06 0.0001243
59 DEVELOPMENTAL MATURATION 12 193 2.017e-06 0.000159
60 POSITIVE REGULATION OF CELL DIFFERENTIATION 26 823 2.12e-06 0.0001644
61 NEGATIVE REGULATION OF HOMOTYPIC CELL CELL ADHESION 9 102 2.276e-06 0.0001736
62 REGULATION OF CELL DEVELOPMENT 26 836 2.821e-06 0.0002117
63 NEURON PROJECTION GUIDANCE 12 205 3.773e-06 0.0002787
64 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 6 38 3.875e-06 0.0002817
65 INTEGRIN MEDIATED SIGNALING PATHWAY 8 82 3.949e-06 0.0002827
66 REGULATION OF IMMUNE RESPONSE 26 858 4.505e-06 0.0003176
67 LEUKOCYTE ACTIVATION 17 414 4.892e-06 0.0003397
68 MOVEMENT IN ENVIRONMENT OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 6.17e-06 0.0003828
69 ENTRY INTO CELL OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 6.17e-06 0.0003828
70 VIRAL ENTRY INTO HOST CELL 8 87 6.17e-06 0.0003828
71 ENTRY INTO OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 6.17e-06 0.0003828
72 MOVEMENT IN HOST ENVIRONMENT 8 87 6.17e-06 0.0003828
73 ENTRY INTO HOST 8 87 6.17e-06 0.0003828
74 CENTRAL NERVOUS SYSTEM DEVELOPMENT 26 872 6.013e-06 0.0003828
75 ENTRY INTO HOST CELL 8 87 6.17e-06 0.0003828
76 NEURONAL ION CHANNEL CLUSTERING 4 12 7.193e-06 0.0004404
77 CELLULAR EXTRAVASATION 5 25 7.622e-06 0.0004606
78 LYMPHOCYTE ACTIVATION 15 342 8.214e-06 0.00049
79 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE OR POLYSACCHARIDE ANTIGEN VIA MHC CLASS II 8 94 1.099e-05 0.0006391
80 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS II 8 94 1.099e-05 0.0006391
81 REGULATION OF CELL PROLIFERATION 36 1496 1.172e-05 0.0006735
82 NEGATIVE REGULATION OF LEUKOCYTE PROLIFERATION 7 69 1.24e-05 0.0007035
83 ADHERENS JUNCTION ORGANIZATION 7 71 1.499e-05 0.0008406
84 REGULATION OF CELL MORPHOGENESIS 19 552 1.67e-05 0.000925
85 REGULATION OF NEURON DIFFERENTIATION 19 554 1.755e-05 0.000948
86 LEARNING 9 131 1.773e-05 0.000948
87 IMMUNE RESPONSE 29 1100 1.77e-05 0.000948
88 NEURON MATURATION 5 30 1.953e-05 0.001033
89 INTERACTION WITH HOST 9 134 2.124e-05 0.001111
90 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 15 372 2.21e-05 0.001143
91 REGULATION OF TRANSPORT 40 1804 2.428e-05 0.001241
92 NEGATIVE REGULATION OF T CELL PROLIFERATION 6 52 2.506e-05 0.001268
93 NEURON CELL CELL ADHESION 4 16 2.553e-05 0.001277
94 NEGATIVE REGULATION OF CELL CELL ADHESION 9 138 2.685e-05 0.001329
95 REGULATION OF LEUKOCYTE MEDIATED CYTOTOXICITY 6 53 2.8e-05 0.001371
96 COGNITION 12 251 2.896e-05 0.001404
97 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 26 957 3.012e-05 0.001416
98 CARDIOVASCULAR SYSTEM DEVELOPMENT 23 788 2.986e-05 0.001416
99 CIRCULATORY SYSTEM DEVELOPMENT 23 788 2.986e-05 0.001416
100 CELL PART MORPHOGENESIS 20 633 3.382e-05 0.001574
101 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 22 750 4.163e-05 0.001918
102 HEAD DEVELOPMENT 21 709 5.455e-05 0.002488
103 FOREBRAIN DEVELOPMENT 14 357 5.621e-05 0.002539
104 POSITIVE REGULATION OF TRANSPORT 25 936 5.693e-05 0.002547
105 TELENCEPHALON DEVELOPMENT 11 228 5.747e-05 0.002547
106 RESPONSE TO CYTOKINE 21 714 6.029e-05 0.002647
107 SKELETAL SYSTEM DEVELOPMENT 16 455 6.126e-05 0.002664
108 REGULATION OF SYSTEM PROCESS 17 507 6.488e-05 0.002795
109 ENSHEATHMENT OF NEURONS 7 91 7.546e-05 0.003164
110 AXON ENSHEATHMENT 7 91 7.546e-05 0.003164
111 REGULATION OF CELL KILLING 6 63 7.547e-05 0.003164
112 NEGATIVE REGULATION OF CELL ACTIVATION 9 158 7.74e-05 0.003216
113 APICAL JUNCTION ASSEMBLY 5 40 8.228e-05 0.003272
114 CELL ACTIVATION 18 568 8.125e-05 0.003272
115 ENDODERMAL CELL DIFFERENTIATION 5 40 8.228e-05 0.003272
116 POSITIVE REGULATION OF NATURAL KILLER CELL MEDIATED IMMUNITY 4 21 8.031e-05 0.003272
117 BEHAVIOR 17 516 8.042e-05 0.003272
118 VASCULATURE DEVELOPMENT 16 469 8.732e-05 0.003436
119 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 26 1021 8.788e-05 0.003436
120 TISSUE DEVELOPMENT 34 1518 8.895e-05 0.003449
121 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 7 94 9.275e-05 0.003542
122 RECEPTOR CLUSTERING 5 41 9.286e-05 0.003542
123 REGULATION OF INTERFERON GAMMA PRODUCTION 7 97 0.0001131 0.00428
124 REGULATION OF SECRETION 20 699 0.0001315 0.004933
125 POSTSYNAPTIC MEMBRANE ORGANIZATION 4 25 0.0001639 0.006099
126 ODONTOGENESIS 7 105 0.0001858 0.006862
127 POSITIVE REGULATION OF NEURON DIFFERENTIATION 12 306 0.000191 0.006997
128 ORGAN MORPHOGENESIS 22 841 0.0002168 0.007822
129 LEUKOCYTE MIGRATION INVOLVED IN INFLAMMATORY RESPONSE 3 11 0.0002169 0.007822
130 POSITIVE REGULATION OF RESPONSE TO STIMULUS 39 1929 0.000224 0.008017
131 REGULATION OF CYTOKINE PRODUCTION 17 563 0.0002272 0.008027
132 REGULATION OF NEURON PROJECTION DEVELOPMENT 14 408 0.0002277 0.008027
133 SYNAPSE ORGANIZATION 8 145 0.0002409 0.008335
134 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 5 50 0.0002418 0.008335
135 ENDODERM FORMATION 5 50 0.0002418 0.008335
136 BLOOD VESSEL MORPHOGENESIS 13 364 0.0002594 0.008874
137 CELL RECOGNITION 8 148 0.0002769 0.009403
NumGOOverlapSizeP ValueAdj. P Value
1 CELL ADHESION MOLECULE BINDING 18 186 3.767e-12 3.499e-09
2 MHC CLASS II RECEPTOR ACTIVITY 6 12 1.656e-09 7.694e-07
3 PEPTIDE ANTIGEN BINDING 7 31 4.342e-08 1.345e-05
4 RECEPTOR ACTIVITY 42 1649 4.331e-07 0.0001006
5 ANTIGEN BINDING 10 114 6.523e-07 0.0001212
6 VIRUS RECEPTOR ACTIVITY 8 70 1.174e-06 0.0001818
7 RECEPTOR BINDING 37 1476 3.435e-06 0.0004558
8 PROTEIN COMPLEX BINDING 26 935 2.029e-05 0.002356
9 CORECEPTOR ACTIVITY 5 38 6.392e-05 0.006598
NumGOOverlapSizeP ValueAdj. P Value
1 CELL SURFACE 45 757 2.451e-20 1.432e-17
2 INTRINSIC COMPONENT OF PLASMA MEMBRANE 63 1649 1.605e-18 4.41e-16
3 SIDE OF MEMBRANE 33 428 2.265e-18 4.41e-16
4 PLASMA MEMBRANE PROTEIN COMPLEX 34 510 5.758e-17 8.406e-15
5 CELL CELL JUNCTION 28 383 3.986e-15 3.879e-13
6 EXTERNAL SIDE OF PLASMA MEMBRANE 23 238 3.437e-15 3.879e-13
7 CELL JUNCTION 46 1151 3.643e-14 3.039e-12
8 MHC PROTEIN COMPLEX 10 27 1.897e-13 1.385e-11
9 APICAL JUNCTION COMPLEX 16 128 1.182e-12 7.669e-11
10 MHC CLASS II PROTEIN COMPLEX 7 16 2.181e-10 1.273e-08
11 PROTEIN COMPLEX INVOLVED IN CELL ADHESION 8 30 1.071e-09 5.215e-08
12 MEMBRANE PROTEIN COMPLEX 36 1020 1.004e-09 5.215e-08
13 ANCHORING JUNCTION 24 489 1.617e-09 7.265e-08
14 LUMENAL SIDE OF MEMBRANE 8 33 2.469e-09 1.03e-07
15 ER TO GOLGI TRANSPORT VESICLE MEMBRANE 9 55 9.98e-09 3.886e-07
16 ER TO GOLGI TRANSPORT VESICLE 9 71 1e-07 3.651e-06
17 NEURON PROJECTION 30 942 2.731e-07 9.383e-06
18 RECEPTOR COMPLEX 16 327 9.916e-07 3.217e-05
19 ENDOCYTIC VESICLE 14 256 1.307e-06 4.017e-05
20 NEURON PART 34 1265 2.01e-06 5.833e-05
21 GOLGI APPARATUS 37 1445 2.098e-06 5.833e-05
22 CELL CELL ADHERENS JUNCTION 7 54 2.348e-06 6.232e-05
23 CELL PROJECTION 42 1786 3.431e-06 8.711e-05
24 COATED VESICLE MEMBRANE 10 139 3.998e-06 9.729e-05
25 MEMBRANE REGION 31 1134 4.265e-06 9.962e-05
26 CLATHRIN COATED ENDOCYTIC VESICLE 7 65 8.311e-06 0.0001809
27 TRANSPORT VESICLE MEMBRANE 10 151 8.362e-06 0.0001809
28 ENDOCYTIC VESICLE MEMBRANE 10 152 8.864e-06 0.0001849
29 CELL SUBSTRATE JUNCTION 16 398 1.218e-05 0.0002452
30 CLATHRIN COATED ENDOCYTIC VESICLE MEMBRANE 6 48 1.568e-05 0.0003053
31 MYELIN SHEATH 10 168 2.124e-05 0.0004002
32 APICOLATERAL PLASMA MEMBRANE 4 16 2.553e-05 0.0004658
33 PLASMA MEMBRANE RECEPTOR COMPLEX 10 175 3.018e-05 0.0005341
34 TRANS GOLGI NETWORK MEMBRANE 7 81 3.565e-05 0.0006123
35 COATED VESICLE 11 234 7.258e-05 0.001211
36 VACUOLAR PART 20 694 0.0001194 0.001938
37 PLASMA MEMBRANE REGION 24 929 0.0001342 0.002118
38 INTRINSIC COMPONENT OF ENDOPLASMIC RETICULUM MEMBRANE 8 136 0.0001552 0.002385
39 GOLGI APPARATUS PART 23 893 0.0001945 0.002912
40 MHC CLASS I PROTEIN COMPLEX 3 11 0.0002169 0.003166
41 BASAL PART OF CELL 5 51 0.0002657 0.003784
42 AXON 14 418 0.0002912 0.004045
43 CORTICAL CYTOSKELETON 6 81 0.0003047 0.004045
44 CLATHRIN COATED VESICLE MEMBRANE 6 81 0.0003047 0.004045
45 INTRINSIC COMPONENT OF ORGANELLE MEMBRANE 11 281 0.0003576 0.00464
46 ENDOSOMAL PART 14 430 0.0003869 0.004912
47 CLATHRIN COATED VESICLE 8 157 0.000412 0.005119
48 SOMATODENDRITIC COMPARTMENT 18 650 0.0004227 0.005143
49 MEMBRANE MICRODOMAIN 11 288 0.0004399 0.005243
50 BASAL PLASMA MEMBRANE 4 33 0.000494 0.005657
51 MAIN AXON 5 58 0.0004863 0.005657

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04514_Cell_adhesion_molecules_.CAMs. 78 136 2.521e-120 4.537e-118
2 hsa04670_Leukocyte_transendothelial_migration 20 117 2.916e-18 2.624e-16
3 hsa04530_Tight_junction 16 133 2.157e-12 1.294e-10
4 hsa04672_Intestinal_immune_network_for_IgA_production 11 49 5.725e-12 2.576e-10
5 hsa04512_ECM.receptor_interaction 11 85 2.941e-09 1.059e-07
6 hsa04612_Antigen_processing_and_presentation 10 78 1.716e-08 5.147e-07
7 hsa04145_Phagosome 13 156 2.466e-08 6.342e-07
8 hsa04810_Regulation_of_actin_cytoskeleton 10 214 0.000162 0.003646
9 hsa04510_Focal_adhesion 9 200 0.0004523 0.009046
10 hsa04151_PI3K_AKT_signaling_pathway 12 351 0.000656 0.01181
11 hsa04660_T_cell_receptor_signaling_pathway 6 108 0.001398 0.02288
12 hsa04970_Salivary_secretion 5 89 0.003326 0.04989
13 hsa04916_Melanogenesis 5 101 0.005697 0.07889
14 hsa04914_Progesterone.mediated_oocyte_maturation 4 87 0.01679 0.2003
15 hsa04640_Hematopoietic_cell_lineage 4 88 0.01744 0.2003
16 hsa04540_Gap_junction 4 90 0.01879 0.2003
17 hsa04650_Natural_killer_cell_mediated_cytotoxicity 5 136 0.01893 0.2003
18 hsa04910_Insulin_signaling_pathway 5 138 0.02003 0.2003
19 hsa04912_GnRH_signaling_pathway 4 101 0.02731 0.2364
20 hsa04972_Pancreatic_secretion 4 101 0.02731 0.2364
21 hsa04144_Endocytosis 6 203 0.02759 0.2364
22 hsa04270_Vascular_smooth_muscle_contraction 4 116 0.04214 0.3344
23 hsa00512_Mucin_type_O.Glycan_biosynthesis 2 30 0.04459 0.3344
24 hsa04520_Adherens_junction 3 73 0.04922 0.3523
25 hsa04971_Gastric_acid_secretion 3 74 0.05088 0.3523
26 hsa00350_Tyrosine_metabolism 2 41 0.07763 0.4991
27 hsa04390_Hippo_signaling_pathway 4 154 0.09625 0.5974
28 hsa04620_Toll.like_receptor_signaling_pathway 3 102 0.1079 0.6471
29 hsa04150_mTOR_signaling_pathway 2 52 0.116 0.6737
30 hsa04114_Oocyte_meiosis 3 114 0.1375 0.7733
31 hsa04920_Adipocytokine_signaling_pathway 2 68 0.1781 0.951
32 hsa04720_Long.term_potentiation 2 70 0.1861 0.951
33 hsa04730_Long.term_depression 2 70 0.1861 0.951
34 hsa04976_Bile_secretion 2 71 0.1902 0.951
35 hsa04370_VEGF_signaling_pathway 2 76 0.2107 1
36 hsa04664_Fc_epsilon_RI_signaling_pathway 2 79 0.2231 1
37 hsa04350_TGF.beta_signaling_pathway 2 85 0.248 1
38 hsa00230_Purine_metabolism 3 162 0.2749 1
39 hsa04014_Ras_signaling_pathway 4 236 0.2751 1
40 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.2897 1
41 hsa04020_Calcium_signaling_pathway 3 177 0.3209 1
42 hsa04010_MAPK_signaling_pathway 4 268 0.3561 1
43 hsa04062_Chemokine_signaling_pathway 3 189 0.3578 1
44 hsa04722_Neurotrophin_signaling_pathway 2 127 0.4193 1
45 hsa04380_Osteoclast_differentiation 2 128 0.4232 1
46 hsa04360_Axon_guidance 2 130 0.4309 1
47 hsa04310_Wnt_signaling_pathway 2 151 0.5084 1
48 hsa04740_Olfactory_transduction 2 388 0.9346 1

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 SNHG5 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-137;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-301a-3p;hsa-miR-302d-3p;hsa-miR-373-3p;hsa-miR-449a;hsa-miR-93-5p 10 ITGB8 Sponge network -0.338 1.0E-5 -1.454 0 0.3

Quest ID: deec5fdc559b7f5a6806f7f9f13fadf2