Explanation
This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
miRNA-gene regulations
| Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | hsa-miR-26a-5p | ABCB9 | -0.13 | 0.44003 | 1.12 | 0 | miRNAWalker2 validate | -0.32 | 0 | NA | |
| 2 | hsa-miR-26a-5p | ACOT11 | -0.13 | 0.44003 | 1.18 | 0 | mirMAP | -0.18 | 0.01305 | NA | |
| 3 | hsa-miR-26a-5p | ACTR3B | -0.13 | 0.44003 | 0.78 | 0 | miRNATAP | -0.23 | 0 | NA | |
| 4 | hsa-miR-26a-5p | ADAM12 | -0.13 | 0.44003 | 2.41 | 0 | mirMAP; miRNATAP | -0.51 | 2.0E-5 | NA | |
| 5 | hsa-miR-26a-5p | ADM | -0.13 | 0.44003 | -0.33 | 0.31881 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.36 | 0.00018 | NA | |
| 6 | hsa-let-7a-5p | AIFM1 | -1.37 | 0 | 0.7 | 0 | TargetScan; miRNATAP | -0.11 | 0.00018 | NA | |
| 7 | hsa-let-7b-5p | AIFM1 | -1.62 | 0 | 0.7 | 0 | miRNATAP | -0.12 | 0 | NA | |
| 8 | hsa-miR-26a-5p | AKIRIN1 | -0.13 | 0.44003 | -0.01 | 0.95575 | miRNATAP | -0.12 | 6.0E-5 | NA | |
| 9 | hsa-let-7a-5p | AKT2 | -1.37 | 0 | 0.16 | 0.1135 | TargetScan | -0.12 | 0 | NA | |
| 10 | hsa-miR-29a-3p | AKT2 | 0.1 | 0.5732 | 0.16 | 0.1135 | MirTarget | -0.1 | 4.0E-5 | 24076586 | Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis |
| 11 | hsa-miR-106b-5p | AKT3 | 1.47 | 0 | -1.44 | 0 | miRNATAP | -0.16 | 0.00426 | NA | |
| 12 | hsa-miR-107 | AKT3 | 0.66 | 0 | -1.44 | 0 | PITA; miRanda | -0.26 | 0.0031 | NA | |
| 13 | hsa-miR-146b-5p | AKT3 | 1.09 | 1.0E-5 | -1.44 | 0 | miRNAWalker2 validate | -0.15 | 0.00189 | NA | |
| 14 | hsa-miR-15a-5p | AKT3 | 1.63 | 0 | -1.44 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.41 | 0 | NA | |
| 15 | hsa-miR-16-5p | AKT3 | 0.75 | 0 | -1.44 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.27 | 0.0001 | NA | |
| 16 | hsa-miR-17-3p | AKT3 | 1.37 | 0 | -1.44 | 0 | miRNATAP | -0.15 | 0.01027 | NA | |
| 17 | hsa-miR-17-5p | AKT3 | 2.07 | 0 | -1.44 | 0 | TargetScan; miRNATAP | -0.22 | 0 | NA | |
| 18 | hsa-miR-181a-5p | AKT3 | -0.38 | 0.05621 | -1.44 | 0 | miRNATAP | -0.23 | 9.0E-5 | NA | |
| 19 | hsa-miR-181b-5p | AKT3 | 0.67 | 0.00024 | -1.44 | 0 | miRNATAP | -0.37 | 0 | NA | |
| 20 | hsa-miR-20a-5p | AKT3 | 2.65 | 0 | -1.44 | 0 | miRNATAP | -0.24 | 0 | NA | |
| 21 | hsa-miR-22-3p | AKT3 | 1.43 | 0 | -1.44 | 0 | miRNATAP | -0.26 | 0.00109 | NA | |
| 22 | hsa-miR-28-3p | AKT3 | 0.39 | 0.00778 | -1.44 | 0 | miRNATAP | -0.2 | 0.01226 | NA | |
| 23 | hsa-miR-29a-3p | AKT3 | 0.1 | 0.5732 | -1.44 | 0 | miRNATAP | -0.15 | 0.02016 | NA | |
| 24 | hsa-miR-29b-2-5p | AKT3 | 0.35 | 0.19484 | -1.44 | 0 | mirMAP | -0.18 | 2.0E-5 | NA | |
| 25 | hsa-miR-29b-3p | AKT3 | 3.11 | 0 | -1.44 | 0 | miRNATAP | -0.27 | 0 | 26512921 | MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 |
| 26 | hsa-miR-3065-5p | AKT3 | 0.65 | 0.09995 | -1.44 | 0 | mirMAP | -0.18 | 0 | NA | |
| 27 | hsa-miR-335-3p | AKT3 | 1.51 | 0 | -1.44 | 0 | mirMAP | -0.13 | 0.01067 | NA | |
| 28 | hsa-miR-362-5p | AKT3 | 0.66 | 0.02433 | -1.44 | 0 | PITA; TargetScan; miRNATAP | -0.23 | 0 | NA | |
| 29 | hsa-miR-542-3p | AKT3 | 1.62 | 0 | -1.44 | 0 | miRanda | -0.19 | 1.0E-5 | NA | |
| 30 | hsa-miR-93-5p | AKT3 | 1.51 | 0 | -1.44 | 0 | miRNATAP | -0.25 | 0 | NA | |
| 31 | hsa-miR-26a-5p | ANKIB1 | -0.13 | 0.44003 | 0.47 | 7.0E-5 | miRNATAP | -0.14 | 3.0E-5 | NA | |
| 32 | hsa-miR-26a-5p | ANKRD52 | -0.13 | 0.44003 | 0.44 | 0.00336 | mirMAP; miRNATAP | -0.19 | 1.0E-5 | NA | |
| 33 | hsa-miR-23a-3p | APAF1 | 0.11 | 0.39309 | 0.05 | 0.6283 | miRNATAP | -0.13 | 0.00069 | 24992592; 24249161 | Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed |
| 34 | hsa-miR-23b-3p | APAF1 | -0.07 | 0.62059 | 0.05 | 0.6283 | miRNATAP | -0.11 | 0.00216 | NA | |
| 35 | hsa-miR-27a-3p | APAF1 | 0.43 | 0.00737 | 0.05 | 0.6283 | miRNATAP | -0.16 | 0 | NA | |
| 36 | hsa-miR-27b-3p | APAF1 | 0.24 | 0.12264 | 0.05 | 0.6283 | miRNATAP | -0.17 | 0 | NA | |
| 37 | hsa-miR-664a-3p | APAF1 | 0.44 | 0.02142 | 0.05 | 0.6283 | mirMAP | -0.11 | 2.0E-5 | NA | |
| 38 | hsa-miR-26a-5p | ARL6IP6 | -0.13 | 0.44003 | 0.14 | 0.36045 | miRNATAP | -0.19 | 1.0E-5 | NA | |
| 39 | hsa-miR-26a-5p | ATAD2 | -0.13 | 0.44003 | 1.58 | 0 | MirTarget | -0.41 | 0 | NA | |
| 40 | hsa-miR-26a-5p | ATAD2B | -0.13 | 0.44003 | 0.61 | 0 | MirTarget; miRNATAP | -0.11 | 0.00236 | NA | |
| 41 | hsa-miR-26a-5p | AURKAIP1 | -0.13 | 0.44003 | 0.63 | 4.0E-5 | miRNAWalker2 validate | -0.16 | 0.00019 | NA | |
| 42 | hsa-miR-26a-5p | AVL9 | -0.13 | 0.44003 | 0.94 | 0 | mirMAP | -0.21 | 0 | NA | |
| 43 | hsa-miR-26a-5p | B3GNT5 | -0.13 | 0.44003 | -0.33 | 0.14374 | MirTarget | -0.24 | 0.00019 | NA | |
| 44 | hsa-miR-26a-5p | BARD1 | -0.13 | 0.44003 | 0.84 | 0.00035 | MirTarget | -0.25 | 0.00017 | NA | |
| 45 | hsa-miR-15a-5p | BCL2 | 1.63 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.19 | 0.00401 | 26915294; 25594541; 18931683; 25623762; 22335947 | As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 |
| 46 | hsa-miR-17-5p | BCL2 | 2.07 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.12 | 0.02174 | 25435430 | Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 |
| 47 | hsa-miR-200c-3p | BCL2 | 0.38 | 0.08422 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase; mirMAP | -0.13 | 0.02205 | NA | |
| 48 | hsa-miR-20a-3p | BCL2 | 2.52 | 0 | -0.49 | 0.06421 | mirMAP | -0.1 | 0.01974 | NA | |
| 49 | hsa-miR-20a-5p | BCL2 | 2.65 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.12 | 0.01368 | NA | |
| 50 | hsa-miR-21-5p | BCL2 | 4.38 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.2 | 1.0E-5 | 22964582; 21468550; 25994220; 25381586; 26555418; 23359184; 21376256 | Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells |
| 51 | hsa-miR-224-5p | BCL2 | 1.92 | 0 | -0.49 | 0.06421 | mirMAP | -0.14 | 0 | 24796455 | In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 |
| 52 | hsa-miR-24-2-5p | BCL2 | 1.44 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.16 | 0.00352 | NA | |
| 53 | hsa-miR-29a-5p | BCL2 | 1.9 | 0 | -0.49 | 0.06421 | mirMAP | -0.24 | 0 | 20041405 | Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 |
| 54 | hsa-miR-3065-5p | BCL2 | 0.65 | 0.09995 | -0.49 | 0.06421 | mirMAP | -0.12 | 0.00023 | NA | |
| 55 | hsa-miR-34a-5p | BCL2 | 1.41 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.19 | 0.00135 | 22964582; 24565525; 23155233; 24444609; 20687223; 22623155; 24988056; 18803879; 19714243; 25053345; 20433755; 21399894; 23862748 | Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression |
| 56 | hsa-miR-365a-3p | BCL2 | 0.01 | 0.9536 | -0.49 | 0.06421 | miRNAWalker2 validate; miRTarBase | -0.14 | 0.01107 | NA | |
| 57 | hsa-miR-450b-5p | BCL2 | 1.69 | 0 | -0.49 | 0.06421 | mirMAP | -0.2 | 0 | NA | |
| 58 | hsa-miR-452-5p | BCL2 | 0.64 | 0.04582 | -0.49 | 0.06421 | mirMAP | -0.12 | 0.00113 | NA | |
| 59 | hsa-miR-542-3p | BCL2 | 1.62 | 0 | -0.49 | 0.06421 | mirMAP | -0.19 | 3.0E-5 | NA | |
| 60 | hsa-miR-590-3p | BCL2 | 0.84 | 0.00129 | -0.49 | 0.06421 | miRanda; mirMAP | -0.12 | 0.02705 | NA | |
| 61 | hsa-miR-590-5p | BCL2 | 2.07 | 0 | -0.49 | 0.06421 | miRanda | -0.18 | 0.00054 | NA | |
| 62 | hsa-miR-96-5p | BCL2 | 3.04 | 0 | -0.49 | 0.06421 | miRNAWalker2 validate; TargetScan | -0.14 | 0.00193 | NA | |
| 63 | hsa-miR-500a-5p | BIRC2 | 0.65 | 0.01047 | -0.06 | 0.62026 | MirTarget | -0.11 | 0 | NA | |
| 64 | hsa-miR-24-1-5p | BIRC3 | 0.86 | 0.00011 | 0.13 | 0.67648 | MirTarget | -0.21 | 0.00165 | NA | |
| 65 | hsa-miR-375 | BIRC3 | 0.62 | 0.1492 | 0.13 | 0.67648 | miRNAWalker2 validate | -0.2 | 0 | 23726271 | Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization |
| 66 | hsa-miR-664a-3p | BIRC3 | 0.44 | 0.02142 | 0.13 | 0.67648 | mirMAP | -0.17 | 0.0216 | NA | |
| 67 | hsa-miR-98-5p | BIRC3 | 1.17 | 0 | 0.13 | 0.67648 | miRNAWalker2 validate | -0.14 | 0.0476 | NA | |
| 68 | hsa-miR-26a-5p | BRWD3 | -0.13 | 0.44003 | 0.68 | 0.00035 | mirMAP | -0.15 | 0.00584 | NA | |
| 69 | hsa-miR-26a-5p | C16orf87 | -0.13 | 0.44003 | 0.57 | 1.0E-5 | mirMAP | -0.12 | 0.00126 | NA | |
| 70 | hsa-miR-26a-5p | C20orf24 | -0.13 | 0.44003 | 1.14 | 0 | miRNATAP | -0.22 | 3.0E-5 | NA | |
| 71 | hsa-miR-107 | CAPN2 | 0.66 | 0 | -0.31 | 0.05176 | miRanda | -0.13 | 0.02025 | NA | |
| 72 | hsa-miR-16-2-3p | CAPN2 | 0.5 | 0.02636 | -0.31 | 0.05176 | mirMAP | -0.11 | 0.00157 | NA | |
| 73 | hsa-miR-20a-3p | CAPN2 | 2.52 | 0 | -0.31 | 0.05176 | MirTarget | -0.13 | 0 | NA | |
| 74 | hsa-miR-320b | CAPN2 | 0.23 | 0.37882 | -0.31 | 0.05176 | miRanda | -0.12 | 1.0E-5 | NA | |
| 75 | hsa-miR-421 | CAPN2 | 0.17 | 0.53528 | -0.31 | 0.05176 | miRanda | -0.16 | 0 | NA | |
| 76 | hsa-miR-590-5p | CAPN2 | 2.07 | 0 | -0.31 | 0.05176 | miRanda | -0.16 | 0 | NA | |
| 77 | hsa-miR-26a-5p | CARM1 | -0.13 | 0.44003 | 0.46 | 1.0E-5 | miRNATAP | -0.16 | 0 | NA | |
| 78 | hsa-miR-148b-5p | CASP10 | 1.39 | 0 | -0.27 | 0.09806 | mirMAP | -0.14 | 2.0E-5 | NA | |
| 79 | hsa-miR-19a-3p | CASP10 | 2.12 | 0 | -0.27 | 0.09806 | MirTarget; mirMAP | -0.1 | 6.0E-5 | NA | |
| 80 | hsa-miR-19b-1-5p | CASP10 | 1.71 | 0 | -0.27 | 0.09806 | mirMAP | -0.18 | 0 | NA | |
| 81 | hsa-miR-19b-3p | CASP10 | 2.11 | 0 | -0.27 | 0.09806 | MirTarget; mirMAP | -0.12 | 0.00012 | NA | |
| 82 | hsa-miR-421 | CASP10 | 0.17 | 0.53528 | -0.27 | 0.09806 | mirMAP | -0.17 | 0 | NA | |
| 83 | hsa-miR-744-3p | CASP10 | 2.07 | 0 | -0.27 | 0.09806 | mirMAP | -0.13 | 0 | NA | |
| 84 | hsa-miR-139-5p | CASP3 | -2.27 | 0 | 0.75 | 0 | miRanda | -0.1 | 0 | NA | |
| 85 | hsa-miR-195-3p | CASP3 | -1.33 | 0 | 0.75 | 0 | MirTarget | -0.12 | 0 | NA | |
| 86 | hsa-miR-30c-5p | CASP3 | -0.33 | 0.1236 | 0.75 | 0 | miRNATAP | -0.15 | 0 | NA | |
| 87 | hsa-miR-30d-5p | CASP3 | -0.92 | 4.0E-5 | 0.75 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.17 | 0 | NA | |
| 88 | hsa-miR-125a-5p | CASP6 | -1.05 | 0 | 0.9 | 0 | miRanda | -0.12 | 0.00016 | NA | |
| 89 | hsa-miR-664a-3p | CASP7 | 0.44 | 0.02142 | -0.21 | 0.08139 | MirTarget | -0.11 | 0.00018 | NA | |
| 90 | hsa-miR-26a-5p | CCDC43 | -0.13 | 0.44003 | 0.57 | 0 | miRNAWalker2 validate | -0.13 | 2.0E-5 | NA | |
| 91 | hsa-miR-26a-5p | CCNE1 | -0.13 | 0.44003 | 3 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.7 | 0 | 22094936 | Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen |
| 92 | hsa-miR-26a-5p | CCNE2 | -0.13 | 0.44003 | 2.15 | 0 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.51 | 0 | 24116110; 21901171 | The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression |
| 93 | hsa-miR-26a-5p | CCNJ | -0.13 | 0.44003 | 0.51 | 0.00036 | miRNATAP | -0.12 | 0.00397 | NA | |
| 94 | hsa-miR-26a-5p | CDC6 | -0.13 | 0.44003 | 3.07 | 0 | miRNAWalker2 validate | -0.73 | 0 | 25100863; 27158389 | Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis |
| 95 | hsa-miR-26a-5p | CDH2 | -0.13 | 0.44003 | 0.21 | 0.68235 | miRNATAP | -0.49 | 0.00061 | NA | |
| 96 | hsa-miR-26a-5p | CDK2AP1 | -0.13 | 0.44003 | 0.32 | 0.01366 | MirTarget; miRNATAP | -0.11 | 0.00207 | NA | |
| 97 | hsa-miR-26a-5p | CDK8 | -0.13 | 0.44003 | 0.3 | 0.03071 | miRNAWalker2 validate | -0.23 | 0 | NA | |
| 98 | hsa-miR-26a-5p | CDR2L | -0.13 | 0.44003 | 0.26 | 0.21768 | miRNATAP | -0.24 | 7.0E-5 | NA | |
| 99 | hsa-miR-26a-5p | CEBPG | -0.13 | 0.44003 | 0.05 | 0.71569 | miRNATAP | -0.11 | 0.00787 | NA | |
| 100 | hsa-miR-26a-5p | CENPP | -0.13 | 0.44003 | 0.51 | 0.00813 | mirMAP | -0.2 | 0.00026 | NA | |
| 101 | hsa-miR-107 | CFLAR | 0.66 | 0 | -0.6 | 0.00015 | miRanda | -0.15 | 0.00732 | NA | |
| 102 | hsa-miR-130b-3p | CFLAR | 1.83 | 0 | -0.6 | 0.00015 | mirMAP | -0.17 | 0 | NA | |
| 103 | hsa-miR-186-5p | CFLAR | 0.85 | 0 | -0.6 | 0.00015 | mirMAP | -0.11 | 0.03888 | NA | |
| 104 | hsa-miR-320b | CFLAR | 0.23 | 0.37882 | -0.6 | 0.00015 | miRanda | -0.15 | 0 | NA | |
| 105 | hsa-miR-330-5p | CFLAR | 0.17 | 0.33643 | -0.6 | 0.00015 | miRanda | -0.11 | 0.0124 | NA | |
| 106 | hsa-miR-421 | CFLAR | 0.17 | 0.53528 | -0.6 | 0.00015 | miRanda | -0.11 | 0.00019 | NA | |
| 107 | hsa-miR-454-3p | CFLAR | 1.49 | 0 | -0.6 | 0.00015 | mirMAP | -0.11 | 0.0011 | NA | |
| 108 | hsa-miR-708-5p | CFLAR | 3.04 | 0 | -0.6 | 0.00015 | mirMAP | -0.1 | 2.0E-5 | NA | |
| 109 | hsa-miR-26a-5p | CHAC1 | -0.13 | 0.44003 | 0.96 | 0.00031 | MirTarget; miRNATAP | -0.23 | 0.00294 | NA | |
| 110 | hsa-miR-26a-5p | CHORDC1 | -0.13 | 0.44003 | 0.88 | 0 | MirTarget | -0.25 | 0 | NA | |
| 111 | hsa-miR-106b-5p | CHP2 | 1.47 | 0 | -0.7 | 0.27547 | MirTarget | -0.29 | 0.04606 | NA | |
| 112 | hsa-miR-582-5p | CHP2 | 1.08 | 0.00149 | -0.7 | 0.27547 | miRNATAP | -0.17 | 0.04861 | NA | |
| 113 | hsa-miR-15a-5p | CHUK | 1.63 | 0 | 0.04 | 0.74424 | miRNAWalker2 validate; miRTarBase; MirTarget | -0.16 | 0 | NA | |
| 114 | hsa-miR-29b-2-5p | CHUK | 0.35 | 0.19484 | 0.04 | 0.74424 | MirTarget | -0.12 | 0 | NA | |
| 115 | hsa-miR-339-5p | CHUK | 0.54 | 0.04881 | 0.04 | 0.74424 | miRanda | -0.1 | 0 | NA | |
| 116 | hsa-miR-342-3p | CHUK | -0.13 | 0.56103 | 0.04 | 0.74424 | miRanda | -0.18 | 0 | NA | |
| 117 | hsa-miR-497-5p | CHUK | -0.05 | 0.78621 | 0.04 | 0.74424 | MirTarget | -0.19 | 0 | NA | |
| 118 | hsa-miR-26a-5p | CLTC | -0.13 | 0.44003 | 0.44 | 9.0E-5 | miRNATAP | -0.13 | 8.0E-5 | NA | |
| 119 | hsa-miR-26a-5p | CNTD2 | -0.13 | 0.44003 | 3.51 | 0 | miRNAWalker2 validate | -0.46 | 0.00192 | NA | |
| 120 | hsa-miR-26a-5p | COASY | -0.13 | 0.44003 | 0.76 | 0 | miRNAWalker2 validate | -0.21 | 0 | NA | |
| 121 | hsa-miR-26a-5p | COL11A1 | -0.13 | 0.44003 | 5.23 | 0 | miRNATAP | -0.98 | 1.0E-5 | NA | |
| 122 | hsa-miR-26a-5p | COL12A1 | -0.13 | 0.44003 | -0.85 | 0.03497 | miRNATAP | -0.35 | 0.00194 | NA | |
| 123 | hsa-miR-26a-5p | COL1A2 | -0.13 | 0.44003 | 0.88 | 0.00369 | MirTarget; miRNATAP | -0.25 | 0.0032 | NA | |
| 124 | hsa-miR-26a-5p | COL5A1 | -0.13 | 0.44003 | 1.57 | 0 | miRNATAP | -0.29 | 0.00093 | NA | |
| 125 | hsa-miR-26a-5p | COPS7B | -0.13 | 0.44003 | 0.71 | 0 | miRNATAP | -0.17 | 0 | NA | |
| 126 | hsa-miR-26a-5p | CPD | -0.13 | 0.44003 | 0.91 | 9.0E-5 | MirTarget; mirMAP | -0.23 | 0.00063 | NA | |
| 127 | hsa-miR-15b-3p | CSF2RB | 0.8 | 0.0004 | -1.28 | 0 | mirMAP | -0.15 | 0.00822 | NA | |
| 128 | hsa-miR-181d-5p | CSF2RB | 1.19 | 0 | -1.28 | 0 | MirTarget | -0.23 | 8.0E-5 | NA | |
| 129 | hsa-miR-19a-3p | CSF2RB | 2.12 | 0 | -1.28 | 0 | MirTarget | -0.17 | 4.0E-5 | NA | |
| 130 | hsa-miR-19b-3p | CSF2RB | 2.11 | 0 | -1.28 | 0 | MirTarget | -0.25 | 0 | NA | |
| 131 | hsa-miR-139-5p | CYCS | -2.27 | 0 | 0.53 | 0.0008 | miRanda | -0.18 | 0 | NA | |
| 132 | hsa-miR-342-3p | CYCS | -0.13 | 0.56103 | 0.53 | 0.0008 | mirMAP | -0.1 | 0.00171 | NA | |
| 133 | hsa-miR-26a-5p | DCUN1D1 | -0.13 | 0.44003 | 0.14 | 0.30132 | mirMAP | -0.11 | 0.00565 | NA | |
| 134 | hsa-miR-26a-5p | DEPDC1 | -0.13 | 0.44003 | 3.45 | 0 | MirTarget | -0.72 | 0 | NA | |
| 135 | hsa-miR-26a-5p | DEPDC1B | -0.13 | 0.44003 | 3.46 | 0 | MirTarget; miRNATAP | -0.61 | 0 | NA | |
| 136 | hsa-miR-342-3p | DFFA | -0.13 | 0.56103 | 0.21 | 0.04672 | mirMAP | -0.12 | 0 | NA | |
| 137 | hsa-miR-664a-3p | DFFA | 0.44 | 0.02142 | 0.21 | 0.04672 | mirMAP | -0.11 | 1.0E-5 | NA | |
| 138 | hsa-miR-365a-3p | DFFB | 0.01 | 0.9536 | 0.55 | 2.0E-5 | MirTarget | -0.12 | 0 | NA | |
| 139 | hsa-miR-26a-5p | DGCR14 | -0.13 | 0.44003 | 0.17 | 0.14595 | mirMAP; miRNATAP | -0.13 | 5.0E-5 | NA | |
| 140 | hsa-miR-26a-5p | DHX15 | -0.13 | 0.44003 | 0.35 | 0.00047 | miRNAWalker2 validate | -0.11 | 0.00018 | NA | |
| 141 | hsa-miR-26a-5p | DLG5 | -0.13 | 0.44003 | 1.13 | 0 | MirTarget; miRNATAP | -0.26 | 0 | NA | |
| 142 | hsa-miR-26a-5p | DNAJC10 | -0.13 | 0.44003 | 0.8 | 0 | mirMAP | -0.11 | 0.00748 | NA | |
| 143 | hsa-miR-26a-5p | DNMT1 | -0.13 | 0.44003 | 0.72 | 0 | miRNAWalker2 validate | -0.27 | 0 | NA | |
| 144 | hsa-miR-26a-5p | E2F2 | -0.13 | 0.44003 | 2.22 | 0 | miRNATAP | -0.5 | 0 | 26458859 | MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC |
| 145 | hsa-miR-26a-5p | E2F7 | -0.13 | 0.44003 | 2.4 | 0 | miRNAWalker2 validate; miRNATAP | -0.46 | 0 | 23096114 | Here we identify E2F7 as a novel target of miR-26a; Thus these findings indicate that the newly identified miR-26a target E2F7 might have an important role in monocytic differentiation and leukemogenesis |
| 146 | hsa-miR-26a-5p | EIF2AK2 | -0.13 | 0.44003 | 0.62 | 9.0E-5 | mirMAP | -0.14 | 0.00185 | NA | |
| 147 | hsa-miR-26a-5p | ELOVL6 | -0.13 | 0.44003 | 0.82 | 0.02787 | miRNAWalker2 validate | -0.26 | 0.01393 | NA | |
| 148 | hsa-miR-130a-3p | ENDOD1 | 0.88 | 0.00016 | 0.06 | 0.80229 | MirTarget | -0.16 | 0.00041 | NA | |
| 149 | hsa-miR-130b-3p | ENDOD1 | 1.83 | 0 | 0.06 | 0.80229 | MirTarget | -0.21 | 0 | NA | |
| 150 | hsa-miR-16-1-3p | ENDOD1 | 1.5 | 0 | 0.06 | 0.80229 | mirMAP | -0.12 | 0.02926 | NA |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | INTRACELLULAR SIGNAL TRANSDUCTION | 57 | 1572 | 3.064e-13 | 1.426e-09 |
| 2 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS | 11 | 39 | 1.367e-12 | 2.12e-09 |
| 3 | REGULATION OF CELL DEATH | 54 | 1472 | 9.476e-13 | 2.12e-09 |
| 4 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 15 | 99 | 1.986e-12 | 2.311e-09 |
| 5 | APOPTOTIC SIGNALING PATHWAY | 23 | 289 | 2.837e-12 | 2.64e-09 |
| 6 | POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS | 53 | 1492 | 5.559e-12 | 4.311e-09 |
| 7 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 59 | 1929 | 1.204e-10 | 7.006e-08 |
| 8 | CELL DEATH | 40 | 1001 | 1.11e-10 | 7.006e-08 |
| 9 | ZYMOGEN ACTIVATION | 14 | 112 | 1.577e-10 | 8.155e-08 |
| 10 | ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 13 | 95 | 2.278e-10 | 1.06e-07 |
| 11 | REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 18 | 213 | 2.713e-10 | 1.148e-07 |
| 12 | POSITIVE REGULATION OF CELL COMMUNICATION | 50 | 1532 | 4.931e-10 | 1.639e-07 |
| 13 | RESPONSE TO OXYGEN CONTAINING COMPOUND | 47 | 1381 | 4.66e-10 | 1.639e-07 |
| 14 | NEGATIVE REGULATION OF CELL DEATH | 36 | 872 | 4.427e-10 | 1.639e-07 |
| 15 | RESPONSE TO NITROGEN COMPOUND | 35 | 859 | 1.123e-09 | 3.484e-07 |
| 16 | REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 25 | 470 | 1.757e-09 | 5.108e-07 |
| 17 | POSITIVE REGULATION OF CATALYTIC ACTIVITY | 48 | 1518 | 3.306e-09 | 9.048e-07 |
| 18 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 53 | 1791 | 4.264e-09 | 1.045e-06 |
| 19 | POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 40 | 1135 | 4.269e-09 | 1.045e-06 |
| 20 | REGULATION OF PEPTIDASE ACTIVITY | 22 | 392 | 6.607e-09 | 1.537e-06 |
| 21 | POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING | 15 | 179 | 9.72e-09 | 2.154e-06 |
| 22 | POSITIVE REGULATION OF PEPTIDASE ACTIVITY | 14 | 154 | 1.077e-08 | 2.278e-06 |
| 23 | POSITIVE REGULATION OF CELL DEATH | 27 | 605 | 1.626e-08 | 3.289e-06 |
| 24 | REGULATION OF KINASE ACTIVITY | 31 | 776 | 1.735e-08 | 3.363e-06 |
| 25 | ACTIVATION OF PROTEIN KINASE ACTIVITY | 18 | 279 | 1.985e-08 | 3.694e-06 |
| 26 | RESPONSE TO MOLECULE OF BACTERIAL ORIGIN | 19 | 321 | 3.174e-08 | 5.68e-06 |
| 27 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 52 | 1848 | 3.308e-08 | 5.701e-06 |
| 28 | DNA METABOLIC PROCESS | 30 | 758 | 3.699e-08 | 6.148e-06 |
| 29 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 36 | 1036 | 4.011e-08 | 6.221e-06 |
| 30 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 36 | 1036 | 4.011e-08 | 6.221e-06 |
| 31 | NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 11 | 98 | 4.724e-08 | 6.869e-06 |
| 32 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 54 | 1977 | 4.583e-08 | 6.869e-06 |
| 33 | POSITIVE REGULATION OF KINASE ACTIVITY | 23 | 482 | 6.007e-08 | 8.471e-06 |
| 34 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 47 | 1618 | 6.798e-08 | 9.304e-06 |
| 35 | POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY | 12 | 132 | 1.232e-07 | 1.584e-05 |
| 36 | REGULATION OF PROTEOLYSIS | 28 | 711 | 1.21e-07 | 1.584e-05 |
| 37 | INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS | 7 | 32 | 1.259e-07 | 1.584e-05 |
| 38 | REGULATION OF PROTEIN MODIFICATION PROCESS | 48 | 1710 | 1.352e-07 | 1.613e-05 |
| 39 | RESPONSE TO CYTOKINE | 28 | 714 | 1.319e-07 | 1.613e-05 |
| 40 | REGULATION OF TRANSFERASE ACTIVITY | 33 | 946 | 1.436e-07 | 1.671e-05 |
| 41 | NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS | 7 | 34 | 1.97e-07 | 2.134e-05 |
| 42 | CELLULAR COMPONENT DISASSEMBLY | 23 | 515 | 1.967e-07 | 2.134e-05 |
| 43 | NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 27 | 684 | 1.972e-07 | 2.134e-05 |
| 44 | I KAPPAB KINASE NF KAPPAB SIGNALING | 9 | 70 | 2.47e-07 | 2.612e-05 |
| 45 | POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 31 | 876 | 2.607e-07 | 2.696e-05 |
| 46 | IMMUNE SYSTEM PROCESS | 52 | 1984 | 3.188e-07 | 3.091e-05 |
| 47 | PROTEIN MATURATION | 16 | 265 | 3.056e-07 | 3.091e-05 |
| 48 | REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING | 15 | 233 | 3.184e-07 | 3.091e-05 |
| 49 | POSITIVE REGULATION OF TRANSFERASE ACTIVITY | 25 | 616 | 3.441e-07 | 3.268e-05 |
| 50 | ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 5 | 13 | 3.762e-07 | 3.501e-05 |
| 51 | CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND | 29 | 799 | 3.907e-07 | 3.564e-05 |
| 52 | EXECUTION PHASE OF APOPTOSIS | 8 | 55 | 4.408e-07 | 3.944e-05 |
| 53 | CELLULAR RESPONSE TO NITROGEN COMPOUND | 22 | 505 | 5.574e-07 | 4.894e-05 |
| 54 | INTRINSIC APOPTOTIC SIGNALING PATHWAY | 12 | 152 | 5.737e-07 | 4.916e-05 |
| 55 | REGULATION OF GLUCOSE TRANSPORT | 10 | 100 | 5.811e-07 | 4.916e-05 |
| 56 | RESPONSE TO ABIOTIC STIMULUS | 33 | 1024 | 8.574e-07 | 7.124e-05 |
| 57 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 45 | 1656 | 8.841e-07 | 7.217e-05 |
| 58 | RESPONSE TO WOUNDING | 23 | 563 | 9.281e-07 | 7.445e-05 |
| 59 | POSITIVE REGULATION OF PROTEOLYSIS | 18 | 363 | 1.002e-06 | 7.899e-05 |
| 60 | RESPONSE TO ENDOGENOUS STIMULUS | 41 | 1450 | 1.082e-06 | 8.121e-05 |
| 61 | NIK NF KAPPAB SIGNALING | 9 | 83 | 1.082e-06 | 8.121e-05 |
| 62 | CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS | 7 | 43 | 1.07e-06 | 8.121e-05 |
| 63 | PROTEIN PHOSPHORYLATION | 31 | 944 | 1.285e-06 | 9.489e-05 |
| 64 | POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 14 | 228 | 1.394e-06 | 0.0001013 |
| 65 | POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING | 6 | 29 | 1.471e-06 | 0.0001053 |
| 66 | CELLULAR RESPONSE TO EXTERNAL STIMULUS | 15 | 264 | 1.545e-06 | 0.000109 |
| 67 | PROTEOLYSIS | 36 | 1208 | 1.629e-06 | 0.0001131 |
| 68 | POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 5 | 17 | 1.735e-06 | 0.0001187 |
| 69 | PHOSPHORYLATION | 36 | 1228 | 2.373e-06 | 0.00016 |
| 70 | TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY | 10 | 118 | 2.679e-06 | 0.0001781 |
| 71 | CELLULAR RESPONSE TO STRESS | 42 | 1565 | 2.992e-06 | 0.0001961 |
| 72 | REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY | 7 | 50 | 3.076e-06 | 0.0001988 |
| 73 | REGULATION OF MAP KINASE ACTIVITY | 16 | 319 | 3.501e-06 | 0.0002231 |
| 74 | REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 11 | 153 | 4.257e-06 | 0.0002677 |
| 75 | REGULATION OF APOPTOTIC SIGNALING PATHWAY | 17 | 363 | 4.339e-06 | 0.0002692 |
| 76 | REGULATION OF CHROMATIN SILENCING | 5 | 21 | 5.473e-06 | 0.0003351 |
| 77 | REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS | 7 | 55 | 5.92e-06 | 0.0003578 |
| 78 | REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 5 | 22 | 7.01e-06 | 0.0004182 |
| 79 | POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS | 4 | 11 | 7.817e-06 | 0.0004604 |
| 80 | RESPONSE TO LIPID | 28 | 888 | 9.309e-06 | 0.0005414 |
| 81 | RESPONSE TO TUMOR NECROSIS FACTOR | 13 | 233 | 9.445e-06 | 0.0005426 |
| 82 | WOUND HEALING | 19 | 470 | 9.847e-06 | 0.0005588 |
| 83 | NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY | 12 | 200 | 1.007e-05 | 0.0005647 |
| 84 | CELLULAR RESPONSE TO CYTOKINE STIMULUS | 22 | 606 | 1.064e-05 | 0.0005896 |
| 85 | POSITIVE REGULATION OF IMMUNE RESPONSE | 21 | 563 | 1.134e-05 | 0.0006209 |
| 86 | POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY | 11 | 171 | 1.232e-05 | 0.0006666 |
| 87 | TOLL LIKE RECEPTOR SIGNALING PATHWAY | 8 | 85 | 1.255e-05 | 0.0006713 |
| 88 | REGULATION OF HYDROLASE ACTIVITY | 36 | 1327 | 1.33e-05 | 0.0006903 |
| 89 | POSITIVE REGULATION OF HYDROLASE ACTIVITY | 28 | 905 | 1.318e-05 | 0.0006903 |
| 90 | INTERSPECIES INTERACTION BETWEEN ORGANISMS | 23 | 662 | 1.35e-05 | 0.0006903 |
| 91 | SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM | 23 | 662 | 1.35e-05 | 0.0006903 |
| 92 | REGULATION OF IMMUNE RESPONSE | 27 | 858 | 1.407e-05 | 0.0006927 |
| 93 | REGULATION OF NIK NF KAPPAB SIGNALING | 6 | 42 | 1.414e-05 | 0.0006927 |
| 94 | REGULATION OF CELL PROLIFERATION | 39 | 1496 | 1.391e-05 | 0.0006927 |
| 95 | PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 5 | 25 | 1.371e-05 | 0.0006927 |
| 96 | RESPONSE TO BACTERIUM | 20 | 528 | 1.479e-05 | 0.0007168 |
| 97 | REGULATION OF RESPONSE TO CYTOKINE STIMULUS | 10 | 144 | 1.582e-05 | 0.0007588 |
| 98 | INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY | 4 | 13 | 1.66e-05 | 0.0007802 |
| 99 | RESPONSE TO MECHANICAL STIMULUS | 12 | 210 | 1.644e-05 | 0.0007802 |
| 100 | DNA CATABOLIC PROCESS | 5 | 27 | 2.04e-05 | 0.0009493 |
| 101 | CYTOKINE MEDIATED SIGNALING PATHWAY | 18 | 452 | 2.069e-05 | 0.0009533 |
| 102 | REGULATION OF NEURON DEATH | 13 | 252 | 2.171e-05 | 0.0009905 |
| 103 | MULTI ORGANISM TRANSPORT | 7 | 68 | 2.458e-05 | 0.001089 |
| 104 | NECROTIC CELL DEATH | 5 | 28 | 2.458e-05 | 0.001089 |
| 105 | MULTI ORGANISM LOCALIZATION | 7 | 68 | 2.458e-05 | 0.001089 |
| 106 | RESPONSE TO HORMONE | 27 | 893 | 2.837e-05 | 0.001245 |
| 107 | APOPTOTIC DNA FRAGMENTATION | 4 | 15 | 3.106e-05 | 0.001351 |
| 108 | PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS | 6 | 49 | 3.5e-05 | 0.001494 |
| 109 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 29 | 1008 | 3.5e-05 | 0.001494 |
| 110 | REGULATION OF NEURON APOPTOTIC PROCESS | 11 | 192 | 3.618e-05 | 0.001531 |
| 111 | POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 9 | 129 | 4.064e-05 | 0.001688 |
| 112 | NUCLEAR IMPORT | 9 | 129 | 4.064e-05 | 0.001688 |
| 113 | POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS | 6 | 51 | 4.414e-05 | 0.001801 |
| 114 | RESPONSE TO NICOTINE | 6 | 51 | 4.414e-05 | 0.001801 |
| 115 | REGULATION OF VIRAL GENOME REPLICATION | 7 | 75 | 4.668e-05 | 0.001889 |
| 116 | REGULATION OF RESPONSE TO STRESS | 37 | 1468 | 4.88e-05 | 0.001958 |
| 117 | PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL | 26 | 873 | 5.165e-05 | 0.002054 |
| 118 | REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS | 4 | 17 | 5.309e-05 | 0.002058 |
| 119 | ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY | 4 | 17 | 5.309e-05 | 0.002058 |
| 120 | ACTIVATION OF PROTEIN KINASE A ACTIVITY | 4 | 17 | 5.309e-05 | 0.002058 |
| 121 | POSITIVE REGULATION OF PROTEIN IMPORT | 8 | 104 | 5.461e-05 | 0.0021 |
| 122 | SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND | 5 | 33 | 5.636e-05 | 0.002132 |
| 123 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND | 5 | 33 | 5.636e-05 | 0.002132 |
| 124 | RESPONSE TO ALKALOID | 9 | 137 | 6.507e-05 | 0.002432 |
| 125 | TRNA TRANSPORT | 5 | 34 | 6.54e-05 | 0.002432 |
| 126 | RESPONSE TO BIOTIC STIMULUS | 26 | 886 | 6.587e-05 | 0.002432 |
| 127 | ORGANOPHOSPHATE BIOSYNTHETIC PROCESS | 17 | 450 | 6.761e-05 | 0.002477 |
| 128 | CELLULAR RESPONSE TO MECHANICAL STIMULUS | 7 | 80 | 7.079e-05 | 0.002573 |
| 129 | REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 15 | 365 | 7.169e-05 | 0.002586 |
| 130 | NEURON APOPTOTIC PROCESS | 5 | 35 | 7.552e-05 | 0.002703 |
| 131 | PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY | 8 | 109 | 7.629e-05 | 0.002705 |
| 132 | REGULATION OF CELLULAR RESPONSE TO STRESS | 22 | 691 | 7.675e-05 | 0.002705 |
| 133 | NEGATIVE REGULATION OF GENE SILENCING | 4 | 19 | 8.475e-05 | 0.002943 |
| 134 | DNA CATABOLIC PROCESS ENDONUCLEOLYTIC | 4 | 19 | 8.475e-05 | 0.002943 |
| 135 | FC EPSILON RECEPTOR SIGNALING PATHWAY | 9 | 142 | 8.587e-05 | 0.00296 |
| 136 | CELLULAR RESPONSE TO HORMONE STIMULUS | 19 | 552 | 8.758e-05 | 0.002996 |
| 137 | POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 13 | 289 | 8.875e-05 | 0.003014 |
| 138 | RESPONSE TO AMINO ACID | 8 | 112 | 9.241e-05 | 0.003116 |
| 139 | REGULATION OF IMMUNE SYSTEM PROCESS | 35 | 1403 | 9.778e-05 | 0.003254 |
| 140 | REGULATION OF ORGANELLE ORGANIZATION | 31 | 1178 | 9.79e-05 | 0.003254 |
| 141 | RESPONSE TO INTERLEUKIN 1 | 8 | 115 | 0.0001113 | 0.003672 |
| 142 | POSITIVE REGULATION OF MAPK CASCADE | 17 | 470 | 0.0001145 | 0.003753 |
| 143 | RESPONSE TO TEMPERATURE STIMULUS | 9 | 148 | 0.0001179 | 0.003838 |
| 144 | POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS | 25 | 867 | 0.0001204 | 0.00389 |
| 145 | ACTIVATION OF IMMUNE RESPONSE | 16 | 427 | 0.0001216 | 0.003901 |
| 146 | REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT | 11 | 220 | 0.0001231 | 0.003923 |
| 147 | LEUKOCYTE MIGRATION | 12 | 259 | 0.0001254 | 0.00397 |
| 148 | NECROPTOTIC PROCESS | 4 | 21 | 0.0001283 | 0.004033 |
| 149 | CELLULAR RESPONSE TO INTERLEUKIN 1 | 7 | 88 | 0.0001298 | 0.004054 |
| 150 | CELL CYCLE | 33 | 1316 | 0.000143 | 0.004437 |
| 151 | POSITIVE REGULATION OF GENE EXPRESSION | 40 | 1733 | 0.0001591 | 0.004871 |
| 152 | POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT | 8 | 121 | 0.0001586 | 0.004871 |
| 153 | INOSITOL LIPID MEDIATED SIGNALING | 8 | 124 | 0.0001878 | 0.005712 |
| 154 | NUCLEAR TRANSPORT | 14 | 355 | 0.0001912 | 0.005776 |
| 155 | PEPTIDYL AMINO ACID MODIFICATION | 24 | 841 | 0.0001929 | 0.00579 |
| 156 | RESPONSE TO ENDOPLASMIC RETICULUM STRESS | 11 | 233 | 0.0002033 | 0.006064 |
| 157 | NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 8 | 126 | 0.0002097 | 0.006213 |
| 158 | CELLULAR RESPONSE TO PEPTIDE | 12 | 274 | 0.0002116 | 0.006231 |
| 159 | RESPONSE TO PEPTIDE | 15 | 404 | 0.0002183 | 0.006366 |
| 160 | PHOSPHOLIPID BIOSYNTHETIC PROCESS | 11 | 235 | 0.0002189 | 0.006366 |
| 161 | REGULATION OF EXECUTION PHASE OF APOPTOSIS | 4 | 24 | 0.000221 | 0.006387 |
| 162 | RESPONSE TO ACID CHEMICAL | 13 | 319 | 0.0002353 | 0.006716 |
| 163 | PROTEIN COMPLEX SUBUNIT ORGANIZATION | 36 | 1527 | 0.0002348 | 0.006716 |
| 164 | INFLAMMATORY RESPONSE | 16 | 454 | 0.0002435 | 0.006908 |
| 165 | POSITIVE REGULATION OF DEFENSE RESPONSE | 14 | 364 | 0.000247 | 0.006966 |
| 166 | NEGATIVE REGULATION OF CHROMATIN MODIFICATION | 5 | 45 | 0.0002563 | 0.007184 |
| 167 | APOPTOTIC NUCLEAR CHANGES | 4 | 25 | 0.0002605 | 0.007258 |
| 168 | IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY | 13 | 323 | 0.0002654 | 0.00735 |
| 169 | CELL CYCLE PROCESS | 28 | 1081 | 0.0002808 | 0.00773 |
| 170 | REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND | 5 | 46 | 0.0002846 | 0.007744 |
| 171 | RESPONSE TO ORGANIC CYCLIC COMPOUND | 25 | 917 | 0.0002834 | 0.007744 |
| 172 | ACTIVATION OF INNATE IMMUNE RESPONSE | 10 | 204 | 0.0002921 | 0.007903 |
| 173 | DEVELOPMENTAL PROGRAMMED CELL DEATH | 4 | 26 | 0.0003048 | 0.008151 |
| 174 | REGULATION OF NECROTIC CELL DEATH | 4 | 26 | 0.0003048 | 0.008151 |
| 175 | REGULATION OF NECROPTOTIC PROCESS | 3 | 11 | 0.0003098 | 0.008236 |
| 176 | FC RECEPTOR SIGNALING PATHWAY | 10 | 206 | 0.0003158 | 0.008254 |
| 177 | NEURON DEATH | 5 | 47 | 0.0003152 | 0.008254 |
| 178 | POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS | 5 | 47 | 0.0003152 | 0.008254 |
| 179 | INTERACTION WITH HOST | 8 | 134 | 0.0003189 | 0.00829 |
| 180 | POSITIVE REGULATION OF INNATE IMMUNE RESPONSE | 11 | 246 | 0.000324 | 0.008354 |
| 181 | RENAL SYSTEM PROCESS | 7 | 102 | 0.000325 | 0.008354 |
| 182 | POSITIVE REGULATION OF MAP KINASE ACTIVITY | 10 | 207 | 0.0003282 | 0.00839 |
| 183 | VASCULATURE DEVELOPMENT | 16 | 469 | 0.000349 | 0.008874 |
| 184 | CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS | 6 | 74 | 0.000356 | 0.008954 |
| 185 | REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE | 4 | 27 | 0.0003543 | 0.008954 |
| 186 | CELLULAR RESPONSE TO DNA DAMAGE STIMULUS | 21 | 720 | 0.0003665 | 0.009168 |
| 187 | IMMUNE RESPONSE | 28 | 1100 | 0.0003712 | 0.009237 |
| 188 | CELLULAR GLUCOSE HOMEOSTASIS | 6 | 75 | 0.0003829 | 0.009477 |
| 189 | NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY | 4 | 28 | 0.0004092 | 0.00994 |
| 190 | REGULATION OF CELLULAR RESPONSE TO HEAT | 6 | 76 | 0.0004114 | 0.00994 |
| 191 | REGULATION OF VITAMIN METABOLIC PROCESS | 3 | 12 | 0.0004091 | 0.00994 |
| 192 | HOMEOSTASIS OF NUMBER OF CELLS | 9 | 175 | 0.0004123 | 0.00994 |
| 193 | POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS | 3 | 12 | 0.0004091 | 0.00994 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | ENZYME BINDING | 60 | 1737 | 5.044e-13 | 4.686e-10 |
| 2 | UBIQUITIN LIKE PROTEIN LIGASE BINDING | 17 | 264 | 5.104e-08 | 2.181e-05 |
| 3 | ADENYL NUCLEOTIDE BINDING | 45 | 1514 | 7.042e-08 | 2.181e-05 |
| 4 | TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING | 8 | 47 | 1.243e-07 | 2.886e-05 |
| 5 | CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS | 5 | 15 | 8.597e-07 | 0.0001597 |
| 6 | KINASE ACTIVITY | 29 | 842 | 1.132e-06 | 0.0001753 |
| 7 | RIBONUCLEOTIDE BINDING | 48 | 1860 | 1.56e-06 | 0.000207 |
| 8 | DEATH RECEPTOR BINDING | 5 | 18 | 2.377e-06 | 0.0002761 |
| 9 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 31 | 992 | 3.575e-06 | 0.000369 |
| 10 | MACROMOLECULAR COMPLEX BINDING | 38 | 1399 | 7.213e-06 | 0.0006701 |
| 11 | DEATH RECEPTOR ACTIVITY | 5 | 24 | 1.108e-05 | 0.0008579 |
| 12 | CYTOKINE RECEPTOR BINDING | 14 | 271 | 1.031e-05 | 0.0008579 |
| 13 | X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 6 | 43 | 1.626e-05 | 0.001162 |
| 14 | KINASE REGULATOR ACTIVITY | 11 | 186 | 2.702e-05 | 0.001793 |
| 15 | PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 7 | 70 | 2.975e-05 | 0.001843 |
| 16 | ENZYME REGULATOR ACTIVITY | 28 | 959 | 3.721e-05 | 0.00216 |
| 17 | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY | 4 | 16 | 4.1e-05 | 0.002241 |
| 18 | PHOSPHATIDYLINOSITOL KINASE ACTIVITY | 6 | 51 | 4.414e-05 | 0.002278 |
| 19 | PROTEASE BINDING | 8 | 104 | 5.461e-05 | 0.00267 |
| 20 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 17 | 445 | 5.895e-05 | 0.002738 |
| 21 | PROTEIN KINASE ACTIVITY | 21 | 640 | 7.346e-05 | 0.00325 |
| 22 | KINASE BINDING | 20 | 606 | 0.0001011 | 0.00427 |
| 23 | PROTEIN HETERODIMERIZATION ACTIVITY | 17 | 468 | 0.0001088 | 0.004345 |
| 24 | CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 7 | 86 | 0.0001123 | 0.004345 |
| 25 | NUCLEAR LOCALIZATION SEQUENCE BINDING | 4 | 21 | 0.0001283 | 0.004766 |
| 26 | HEAT SHOCK PROTEIN BINDING | 7 | 89 | 0.0001394 | 0.004981 |
| 27 | PROTEIN DIMERIZATION ACTIVITY | 30 | 1149 | 0.0001466 | 0.005043 |
| 28 | IDENTICAL PROTEIN BINDING | 31 | 1209 | 0.000156 | 0.005176 |
| 29 | CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS | 5 | 42 | 0.0001841 | 0.005896 |
| 30 | INSULIN RECEPTOR SUBSTRATE BINDING | 3 | 11 | 0.0003098 | 0.009592 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | CATALYTIC COMPLEX | 40 | 1038 | 3.252e-10 | 1.899e-07 |
| 2 | TRANSFERASE COMPLEX | 31 | 703 | 1.717e-09 | 5.014e-07 |
| 3 | PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX | 7 | 20 | 3.303e-09 | 6.431e-07 |
| 4 | TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 17 | 237 | 1.04e-08 | 1.518e-06 |
| 5 | MEMBRANE MICRODOMAIN | 15 | 288 | 4.503e-06 | 0.0005259 |
| 6 | PROTEIN KINASE COMPLEX | 8 | 90 | 1.914e-05 | 0.001863 |
| 7 | NUCLEAR PORE | 7 | 77 | 5.535e-05 | 0.004618 |
Over-represented Pathway
| Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|---|
| 1 | hsa04210_Apoptosis | 59 | 89 | 3.217e-92 | 5.791e-90 | |
| 2 | hsa04380_Osteoclast_differentiation | 21 | 128 | 1.212e-17 | 1.091e-15 | |
| 3 | hsa04650_Natural_killer_cell_mediated_cytotoxicity | 21 | 136 | 4.409e-17 | 2.353e-15 | |
| 4 | hsa04662_B_cell_receptor_signaling_pathway | 17 | 75 | 5.229e-17 | 2.353e-15 | |
| 5 | hsa04660_T_cell_receptor_signaling_pathway | 19 | 108 | 1.151e-16 | 4.142e-15 | |
| 6 | hsa04010_MAPK_signaling_pathway | 26 | 268 | 8.835e-16 | 2.65e-14 | |
| 7 | hsa04620_Toll.like_receptor_signaling_pathway | 16 | 102 | 2.046e-13 | 5.261e-12 | |
| 8 | hsa04722_Neurotrophin_signaling_pathway | 17 | 127 | 5.229e-13 | 1.176e-11 | |
| 9 | hsa04370_VEGF_signaling_pathway | 14 | 76 | 6.768e-13 | 1.354e-11 | |
| 10 | hsa04510_Focal_adhesion | 19 | 200 | 1.103e-11 | 1.986e-10 | |
| 11 | hsa04910_Insulin_signaling_pathway | 16 | 138 | 2.406e-11 | 3.937e-10 | |
| 12 | hsa04150_mTOR_signaling_pathway | 10 | 52 | 9.057e-10 | 1.359e-08 | |
| 13 | hsa04973_Carbohydrate_digestion_and_absorption | 9 | 44 | 3.589e-09 | 4.969e-08 | |
| 14 | hsa04914_Progesterone.mediated_oocyte_maturation | 11 | 87 | 1.335e-08 | 1.717e-07 | |
| 15 | hsa04151_PI3K_AKT_signaling_pathway | 20 | 351 | 2.569e-08 | 3.082e-07 | |
| 16 | hsa04664_Fc_epsilon_RI_signaling_pathway | 10 | 79 | 6.108e-08 | 6.871e-07 | |
| 17 | hsa04062_Chemokine_signaling_pathway | 14 | 189 | 1.434e-07 | 1.518e-06 | |
| 18 | hsa04114_Oocyte_meiosis | 11 | 114 | 2.269e-07 | 2.269e-06 | |
| 19 | hsa04621_NOD.like_receptor_signaling_pathway | 8 | 59 | 7.683e-07 | 7.279e-06 | |
| 20 | hsa04960_Aldosterone.regulated_sodium_reabsorption | 7 | 42 | 9.058e-07 | 8.152e-06 | |
| 21 | hsa04012_ErbB_signaling_pathway | 9 | 87 | 1.615e-06 | 1.384e-05 | |
| 22 | hsa04014_Ras_signaling_pathway | 14 | 236 | 2.094e-06 | 1.713e-05 | |
| 23 | hsa04115_p53_signaling_pathway | 8 | 69 | 2.597e-06 | 2.032e-05 | |
| 24 | hsa04720_Long.term_potentiation | 8 | 70 | 2.9e-06 | 2.175e-05 | |
| 25 | hsa04666_Fc_gamma_R.mediated_phagocytosis | 9 | 95 | 3.387e-06 | 2.439e-05 | |
| 26 | hsa04920_Adipocytokine_signaling_pathway | 7 | 68 | 2.458e-05 | 0.0001702 | |
| 27 | hsa04630_Jak.STAT_signaling_pathway | 10 | 155 | 2.993e-05 | 0.0001995 | |
| 28 | hsa04070_Phosphatidylinositol_signaling_system | 7 | 78 | 6.015e-05 | 0.0003867 | |
| 29 | hsa04310_Wnt_signaling_pathway | 9 | 151 | 0.0001374 | 0.0008529 | |
| 30 | hsa04622_RIG.I.like_receptor_signaling_pathway | 6 | 71 | 0.0002841 | 0.001704 | |
| 31 | hsa04810_Regulation_of_actin_cytoskeleton | 10 | 214 | 0.0004268 | 0.002478 | |
| 32 | hsa04623_Cytosolic_DNA.sensing_pathway | 5 | 56 | 0.0007155 | 0.004024 | |
| 33 | hsa04670_Leukocyte_transendothelial_migration | 7 | 117 | 0.0007432 | 0.004054 | |
| 34 | hsa04020_Calcium_signaling_pathway | 8 | 177 | 0.001957 | 0.01036 | |
| 35 | hsa04120_Ubiquitin_mediated_proteolysis | 7 | 139 | 0.002022 | 0.0104 | |
| 36 | hsa04640_Hematopoietic_cell_lineage | 5 | 88 | 0.005288 | 0.02644 | |
| 37 | hsa04141_Protein_processing_in_endoplasmic_reticulum | 7 | 168 | 0.005752 | 0.02734 | |
| 38 | hsa04110_Cell_cycle | 6 | 128 | 0.005918 | 0.02734 | |
| 39 | hsa00562_Inositol_phosphate_metabolism | 4 | 57 | 0.005925 | 0.02734 | |
| 40 | hsa04974_Protein_digestion_and_absorption | 4 | 81 | 0.01973 | 0.08879 | |
| 41 | hsa04512_ECM.receptor_interaction | 4 | 85 | 0.0231 | 0.1014 | |
| 42 | hsa04360_Axon_guidance | 5 | 130 | 0.02527 | 0.1083 | |
| 43 | hsa03013_RNA_transport | 5 | 152 | 0.04483 | 0.1873 | |
| 44 | hsa00030_Pentose_phosphate_pathway | 2 | 27 | 0.04579 | 0.1873 | |
| 45 | hsa04520_Adherens_junction | 3 | 73 | 0.06589 | 0.2635 | |
| 46 | hsa00564_Glycerophospholipid_metabolism | 3 | 80 | 0.08171 | 0.313 | |
| 47 | hsa04530_Tight_junction | 4 | 133 | 0.08967 | 0.3362 | |
| 48 | hsa04962_Vasopressin.regulated_water_reabsorption | 2 | 44 | 0.1075 | 0.3947 | |
| 49 | hsa04912_GnRH_signaling_pathway | 3 | 101 | 0.1374 | 0.4948 | |
| 50 | hsa04742_Taste_transduction | 2 | 52 | 0.1413 | 0.4986 | |
| 51 | hsa00500_Starch_and_sucrose_metabolism | 2 | 54 | 0.15 | 0.5146 | |
| 52 | hsa00230_Purine_metabolism | 4 | 162 | 0.1515 | 0.5146 | |
| 53 | hsa04340_Hedgehog_signaling_pathway | 2 | 56 | 0.1589 | 0.5297 | |
| 54 | hsa04270_Vascular_smooth_muscle_contraction | 3 | 116 | 0.1832 | 0.5842 | |
| 55 | hsa04976_Bile_secretion | 2 | 71 | 0.2278 | 0.6835 | |
| 56 | hsa04971_Gastric_acid_secretion | 2 | 74 | 0.2419 | 0.7023 | |
| 57 | hsa04612_Antigen_processing_and_presentation | 2 | 78 | 0.2607 | 0.7319 | |
| 58 | hsa04970_Salivary_secretion | 2 | 89 | 0.3124 | 0.8034 | |
| 59 | hsa04540_Gap_junction | 2 | 90 | 0.3171 | 0.804 | |
| 60 | hsa00240_Pyrimidine_metabolism | 2 | 99 | 0.3588 | 0.8517 | |
| 61 | hsa04916_Melanogenesis | 2 | 101 | 0.3679 | 0.8517 | |
| 62 | hsa04142_Lysosome | 2 | 121 | 0.456 | 0.9829 | |
| 63 | hsa04144_Endocytosis | 3 | 203 | 0.4777 | 0.9829 | |
| 64 | hsa03040_Spliceosome | 2 | 128 | 0.4852 | 0.9829 | |
| 65 | hsa04390_Hippo_signaling_pathway | 2 | 154 | 0.5846 | 1 | |
| 66 | hsa04740_Olfactory_transduction | 2 | 388 | 0.9593 | 1 |
lncRNA-mediated sponge
| Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | TBX5-AS1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-450b-5p;hsa-miR-590-5p;hsa-miR-629-3p | 21 | PIK3R1 | Sponge network | -2.108 | 0 | -1.285 | 0 | 0.544 |
| 2 | AC109642.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-96-5p | 20 | PIK3R1 | Sponge network | -2.791 | 0 | -1.285 | 0 | 0.529 |
| 3 | RP11-389C8.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 18 | PIK3R1 | Sponge network | -2.039 | 0 | -1.285 | 0 | 0.52 |
| 4 | LINC00968 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 22 | PIK3R1 | Sponge network | -4.19 | 0 | -1.285 | 0 | 0.51 |
| 5 | RP11-720L2.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -2.305 | 0 | -1.285 | 0 | 0.496 |
| 6 | LINC00702 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-582-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 26 | PIK3R1 | Sponge network | -2.856 | 0 | -1.285 | 0 | 0.494 |
| 7 | MAGI2-AS3 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 22 | PIK3R1 | Sponge network | -1.892 | 0 | -1.285 | 0 | 0.486 |
| 8 | LINC00702 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-93-5p | 11 | AKT3 | Sponge network | -2.856 | 0 | -1.44 | 0 | 0.485 |
| 9 | LINC00472 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -2.952 | 0 | -1.285 | 0 | 0.458 |
| 10 | FENDRR |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 19 | PIK3R1 | Sponge network | -4.222 | 0 | -1.285 | 0 | 0.438 |
| 11 | AC007743.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 17 | PIK3R1 | Sponge network | -2.595 | 0 | -1.285 | 0 | 0.436 |
| 12 | AF131215.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-589-3p | 12 | PIK3R1 | Sponge network | -2.09 | 0 | -1.285 | 0 | 0.428 |
| 13 | RP11-456K23.1 |
hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-29a-5p;hsa-miR-450b-5p;hsa-miR-542-3p;hsa-miR-590-3p;hsa-miR-590-5p | 11 | BCL2 | Sponge network | -1.488 | 0 | -0.487 | 0.06421 | 0.423 |
| 14 | RP11-1024P17.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p | 18 | PIK3R1 | Sponge network | -2.062 | 0 | -1.285 | 0 | 0.418 |
| 15 | RP11-400K9.4 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29b-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.193 | 0.00359 | -1.285 | 0 | 0.418 |
| 16 | RP11-672A2.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-424-5p | 12 | PIK3R1 | Sponge network | -2.68 | 0 | -1.285 | 0 | 0.417 |
| 17 | RP11-456K23.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 23 | PIK3R1 | Sponge network | -1.488 | 0 | -1.285 | 0 | 0.416 |
| 18 | RP11-354E11.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -2.138 | 0 | -1.285 | 0 | 0.41 |
| 19 | RP11-401P9.4 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-590-5p;hsa-miR-93-5p | 14 | PIK3R1 | Sponge network | -3.04 | 0 | -1.285 | 0 | 0.408 |
| 20 | CTD-2013N24.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 20 | PIK3R1 | Sponge network | -1.745 | 0 | -1.285 | 0 | 0.407 |
| 21 | RP11-532F6.3 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-3p;hsa-miR-629-3p | 15 | PIK3R1 | Sponge network | -2.028 | 0 | -1.285 | 0 | 0.395 |
| 22 | MIR497HG |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 23 | PIK3R1 | Sponge network | -2.142 | 0 | -1.285 | 0 | 0.391 |
| 23 | RP11-456K23.1 |
hsa-miR-106b-5p;hsa-miR-146b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-22-3p;hsa-miR-28-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-542-3p;hsa-miR-93-5p | 14 | AKT3 | Sponge network | -1.488 | 0 | -1.44 | 0 | 0.389 |
| 24 | TBX5-AS1 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-28-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-542-3p | 12 | AKT3 | Sponge network | -2.108 | 0 | -1.44 | 0 | 0.386 |
| 25 | MAGI2-AS3 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-93-5p | 11 | AKT3 | Sponge network | -1.892 | 0 | -1.44 | 0 | 0.386 |
| 26 | RP11-399O19.9 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -0.873 | 0.00072 | -1.285 | 0 | 0.38 |
| 27 | FGF14-AS2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | -2.159 | 0 | -1.285 | 0 | 0.378 |
| 28 | HHIP-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p | 15 | PIK3R1 | Sponge network | -2.807 | 0 | -1.285 | 0 | 0.374 |
| 29 | LINC00092 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p | 14 | PIK3R1 | Sponge network | -2.383 | 0 | -1.285 | 0 | 0.369 |
| 30 | RP11-378A13.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 17 | PIK3R1 | Sponge network | -1.713 | 0 | -1.285 | 0 | 0.367 |
| 31 | CTD-2013N24.2 |
hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-20a-5p;hsa-miR-22-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-93-5p | 13 | AKT3 | Sponge network | -1.745 | 0 | -1.44 | 0 | 0.366 |
| 32 | SH3RF3-AS1 | hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-582-5p;hsa-miR-590-5p | 15 | PIK3R1 | Sponge network | -1.583 | 0 | -1.285 | 0 | 0.364 |
| 33 | AC011899.9 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p | 16 | PIK3R1 | Sponge network | -2.611 | 0 | -1.285 | 0 | 0.364 |
| 34 | AC079630.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -3.758 | 0 | -1.285 | 0 | 0.359 |
| 35 | RP5-1042I8.7 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 14 | PIK3R1 | Sponge network | -0.733 | 0.00018 | -1.285 | 0 | 0.358 |
| 36 | AC003090.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 17 | PIK3R1 | Sponge network | -3.16 | 2.0E-5 | -1.285 | 0 | 0.358 |
| 37 | GAS6-AS2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-5p | 17 | PIK3R1 | Sponge network | -1.761 | 0 | -1.285 | 0 | 0.354 |
| 38 | MAGI2-AS3 |
hsa-miR-141-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-324-5p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-421;hsa-miR-501-5p;hsa-miR-589-3p;hsa-miR-660-5p | 11 | IRAK3 | Sponge network | -1.892 | 0 | -1.317 | 1.0E-5 | 0.348 |
| 39 | LINC00961 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-96-5p | 15 | PIK3R1 | Sponge network | -2.724 | 0 | -1.285 | 0 | 0.346 |
| 40 | RBMS3-AS3 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-629-3p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -2.307 | 0.0011 | -1.285 | 0 | 0.345 |
| 41 | AC010226.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -1.081 | 2.0E-5 | -1.285 | 0 | 0.344 |
| 42 | AC003991.3 |
hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-20a-3p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-335-3p;hsa-miR-590-3p | 11 | ENDOD1 | Sponge network | -0.787 | 0.08132 | 0.057 | 0.80229 | 0.343 |
| 43 | LINC00987 | hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-93-5p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -0.927 | 0 | -1.285 | 0 | 0.343 |
| 44 | BZRAP1-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -0.785 | 0.00723 | -1.285 | 0 | 0.34 |
| 45 | AC011526.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -2.783 | 0 | -1.285 | 0 | 0.338 |
| 46 | AC004947.2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 17 | PIK3R1 | Sponge network | -3.94 | 0 | -1.285 | 0 | 0.332 |
| 47 | CTC-523E23.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-590-3p | 11 | PIK3R1 | Sponge network | -1.636 | 0.00051 | -1.285 | 0 | 0.33 |
| 48 | WDFY3-AS2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -1.297 | 0 | -1.285 | 0 | 0.329 |
| 49 | CTD-2003C8.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-590-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -3.403 | 0 | -1.285 | 0 | 0.328 |
| 50 | LINC00883 | hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p | 12 | PIK3R1 | Sponge network | -1.466 | 0 | -1.285 | 0 | 0.327 |
| 51 | RP11-293M10.6 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -1.199 | 0.00063 | -1.285 | 0 | 0.32 |
| 52 | RP11-354E11.2 |
hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-335-3p;hsa-miR-590-3p | 12 | ENDOD1 | Sponge network | -2.138 | 0 | 0.057 | 0.80229 | 0.32 |
| 53 | RP11-434D9.1 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -4.573 | 0 | -1.285 | 0 | 0.319 |
| 54 | NR2F1-AS1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 18 | PIK3R1 | Sponge network | -0.427 | 0.1559 | -1.285 | 0 | 0.318 |
| 55 | CTC-559E9.4 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.737 | 0.0562 | -1.285 | 0 | 0.318 |
| 56 | RP11-789C1.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -4.664 | 0.00012 | -1.285 | 0 | 0.317 |
| 57 | LINC00607 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p | 15 | PIK3R1 | Sponge network | -2.277 | 0 | -1.285 | 0 | 0.316 |
| 58 | RP11-517P14.2 | hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-590-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.795 | 6.0E-5 | -1.285 | 0 | 0.315 |
| 59 | RP4-639F20.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -1.312 | 0 | -1.285 | 0 | 0.314 |
| 60 | RP11-244O19.1 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -0.428 | 0.21699 | -1.285 | 0 | 0.303 |
| 61 | RP11-462G12.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -1.071 | 0.01175 | -1.285 | 0 | 0.302 |
| 62 | LINC01088 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.385 | 0.01604 | -1.285 | 0 | 0.3 |
| 63 | AC016735.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-582-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -2.711 | 0.00282 | -1.285 | 0 | 0.298 |
| 64 | RP11-67L2.2 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -1.062 | 0 | -1.285 | 0 | 0.298 |
| 65 | TBX5-AS1 |
hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-365a-3p;hsa-miR-450b-5p;hsa-miR-542-3p;hsa-miR-590-5p | 12 | BCL2 | Sponge network | -2.108 | 0 | -0.487 | 0.06421 | 0.297 |
| 66 | LINC00702 |
hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29a-5p;hsa-miR-34a-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-96-5p | 12 | BCL2 | Sponge network | -2.856 | 0 | -0.487 | 0.06421 | 0.297 |
| 67 | RP11-88I21.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -8.789 | 0 | -1.285 | 0 | 0.297 |
| 68 | RP11-1008C21.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-629-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -1.249 | 0 | -1.285 | 0 | 0.297 |
| 69 | AC034187.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.974 | 0 | -1.285 | 0 | 0.297 |
| 70 | RP11-365O16.3 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -2.765 | 0.00017 | -1.285 | 0 | 0.293 |
| 71 | FENDRR |
hsa-miR-141-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-3200-3p;hsa-miR-324-5p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-421;hsa-miR-450b-5p | 10 | IRAK3 | Sponge network | -4.222 | 0 | -1.317 | 1.0E-5 | 0.291 |
| 72 | CASC2 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -1.086 | 0 | -1.285 | 0 | 0.29 |
| 73 | LINC00702 |
hsa-miR-141-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-421;hsa-miR-450b-5p;hsa-miR-501-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-660-5p | 12 | IRAK3 | Sponge network | -2.856 | 0 | -1.317 | 1.0E-5 | 0.285 |
| 74 | RP11-284N8.3 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -0.761 | 0.05061 | -1.285 | 0 | 0.285 |
| 75 | AF131215.9 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-3p | 12 | PIK3R1 | Sponge network | -1.808 | 0 | -1.285 | 0 | 0.282 |
| 76 | RP11-352D13.6 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 15 | PIK3R1 | Sponge network | -4.634 | 0 | -1.285 | 0 | 0.28 |
| 77 | LIPE-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-5p;hsa-miR-93-5p | 14 | PIK3R1 | Sponge network | -0.734 | 0.00039 | -1.285 | 0 | 0.28 |
| 78 | RP11-476D10.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -4.519 | 0 | -1.285 | 0 | 0.279 |
| 79 | BDNF-AS | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -0.568 | 0.02011 | -1.285 | 0 | 0.277 |
| 80 | CTD-2135D7.5 | hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-5p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -3.162 | 0 | -1.285 | 0 | 0.277 |
| 81 | CTC-441N14.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-582-5p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | -2.273 | 0.01231 | -1.285 | 0 | 0.276 |
| 82 | LINC00443 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p | 14 | PIK3R1 | Sponge network | -3.704 | 0.0003 | -1.285 | 0 | 0.276 |
| 83 | AC008268.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -5.661 | 0 | -1.285 | 0 | 0.276 |
| 84 | RP11-1008C21.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p | 13 | PIK3R1 | Sponge network | -1.826 | 3.0E-5 | -1.285 | 0 | 0.272 |
| 85 | SNHG18 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -1.073 | 0.00533 | -1.285 | 0 | 0.27 |
| 86 | C1orf132 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 12 | PIK3R1 | Sponge network | -0.86 | 0.02429 | -1.285 | 0 | 0.269 |
| 87 | LINC00551 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-629-3p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -2.179 | 0.00466 | -1.285 | 0 | 0.269 |
| 88 | TBX5-AS1 |
hsa-miR-141-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-3200-3p;hsa-miR-324-5p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-421;hsa-miR-450b-5p;hsa-miR-501-5p;hsa-miR-590-5p | 12 | IRAK3 | Sponge network | -2.108 | 0 | -1.317 | 1.0E-5 | 0.267 |
| 89 | LINC01024 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -0.659 | 0.02711 | -1.285 | 0 | 0.266 |
| 90 | CTC-366B18.4 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.652 | 0.01265 | -1.285 | 0 | 0.265 |
| 91 | NR2F1-AS1 |
hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-582-5p;hsa-miR-7-1-3p;hsa-miR-93-5p | 10 | IL1RAP | Sponge network | -0.427 | 0.1559 | 0 | 0.99919 | 0.265 |
| 92 | RP1-78O14.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -4.409 | 0 | -1.285 | 0 | 0.264 |
| 93 | AC096670.3 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -1.939 | 7.0E-5 | -1.285 | 0 | 0.263 |
| 94 | AC007743.1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-142-5p;hsa-miR-148a-3p;hsa-miR-155-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29a-5p;hsa-miR-590-5p | 11 | PRKAR2A | Sponge network | -2.595 | 0 | -0.542 | 0.00821 | 0.263 |
| 95 | RP5-839B4.8 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-629-3p;hsa-miR-93-5p | 14 | PIK3R1 | Sponge network | -5.037 | 0 | -1.285 | 0 | 0.262 |
| 96 | DIO3OS | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-629-3p | 14 | PIK3R1 | Sponge network | -1.936 | 0.00085 | -1.285 | 0 | 0.262 |
| 97 | CTC-523E23.1 | hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-3p;hsa-miR-629-3p | 10 | PIK3R1 | Sponge network | -1.223 | 0.0005 | -1.285 | 0 | 0.262 |
| 98 | RP4-668J24.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -2.397 | 0.00331 | -1.285 | 0 | 0.261 |
| 99 | RP11-347J14.7 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -5.394 | 0 | -1.285 | 0 | 0.261 |
| 100 | LINC00261 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p | 17 | PIK3R1 | Sponge network | -2.566 | 0.00025 | -1.285 | 0 | 0.259 |
| 101 | AGAP11 | hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-5p;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -2.127 | 0 | -1.285 | 0 | 0.255 |
| 102 | LINC00619 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p | 11 | PIK3R1 | Sponge network | -2.307 | 0.02217 | -1.285 | 0 | 0.255 |
| 103 | DNM3OS |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p | 16 | PIK3R1 | Sponge network | 0.053 | 0.85755 | -1.285 | 0 | 0.255 |
| 104 | CTA-221G9.11 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-128-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -0.645 | 0.06404 | -1.285 | 0 | 0.254 |
| 105 | PCED1B-AS1 |
hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-335-3p;hsa-miR-93-5p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | -0.672 | 0.02084 | -1.285 | 0 | 0.254 |
| 106 | RP11-677M14.3 | hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -1.866 | 0 | -1.285 | 0 | 0.251 |
| 107 | MIR497HG |
hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-29a-5p;hsa-miR-450b-5p;hsa-miR-590-5p;hsa-miR-96-5p | 10 | BCL2 | Sponge network | -2.142 | 0 | -0.487 | 0.06421 | 0.251 |