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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-22-3p A4GNT -0.63 0 -1.24 0.00042 MirTarget -0.76 0 NA
2 hsa-miR-22-3p ACLY -0.63 0 1.02 0 MirTarget -0.34 0 27317765; 26477310 Herein four different types of tumor cells including osteosarcoma prostate cervical and lung cancers were adopted in our study and we have demonstrated that miR-22 directly downregulated ACLY; Moreover miR-22 was proved to attenuate cancer cell proliferation and invasion as well as promote cell apoptosis via inhibiting ACLY; Additionally we confirmed the higher ACLY protein levels and the lower miR-22 expressions in hundreds of clinical samples of the four primary tumors and a negative correlation relationship between ACLY and miR-22 was clarified; These findings provide unequivocal proofs that miR-22 is responsible for the posttranscriptional regulation of ACLY which yields promising therapeutic effects in osteosarcoma prostate cervical and lung cancers;Within this cluster the cancer-associated and cardioprotective miR-22 was shown to repress fatty acid synthesis and elongation in tumour cells by targeting ATP citrate lyase and fatty acid elongase 6 as well as impairing mitochondrial one-carbon metabolism by suppression of methylene tetrahydrofolate dehydrogenase/cyclohydrolase
3 hsa-miR-22-3p ADAP1 -0.63 0 -0.91 0.00084 mirMAP -0.52 5.0E-5 NA
4 hsa-miR-22-3p ADCK2 -0.63 0 0.53 0 MirTarget -0.15 0.00087 NA
5 hsa-miR-22-3p ADM2 -0.63 0 1.72 0 mirMAP -0.86 0 NA
6 hsa-miR-22-3p AGBL5 -0.63 0 0.72 0 MirTarget; miRNATAP -0.33 0 NA
7 hsa-miR-22-3p ALMS1 -0.63 0 0.54 0 miRNAWalker2 validate -0.23 0 NA
8 hsa-miR-22-3p ANXA13 -0.63 0 -0.63 0.168 MirTarget -0.72 0.00066 NA
9 hsa-miR-22-3p ARFIP2 -0.63 0 0.37 0 MirTarget; miRNATAP -0.17 0 NA
10 hsa-miR-22-3p ARID3B -0.63 0 0.46 0.00021 MirTarget; miRNATAP -0.39 0 NA
11 hsa-miR-22-3p ARID5B -0.63 0 -0.52 0.00012 miRNAWalker2 validate -0.16 0.01242 NA
12 hsa-miR-22-3p ASB6 -0.63 0 0.35 0 MirTarget -0.21 0 NA
13 hsa-miR-22-3p ATP9A -0.63 0 0.35 0.03032 MirTarget -0.32 3.0E-5 NA
14 hsa-miR-22-3p B4GALT5 -0.63 0 -0.52 0 MirTarget -0.21 5.0E-5 NA
15 hsa-miR-22-3p BCL9 -0.63 0 1.18 0 MirTarget; miRNATAP -0.61 0 NA
16 hsa-miR-22-3p BIN1 -0.63 0 0.29 0.02481 MirTarget; miRNATAP -0.14 0.01955 NA
17 hsa-miR-22-3p BMP7 -0.63 0 0.83 0.04887 miRNAWalker2 validate; miRTarBase -0.87 1.0E-5 NA
18 hsa-miR-22-3p BRSK2 -0.63 0 1.39 0.0004 MirTarget; miRNATAP -1.07 0 NA
19 hsa-miR-22-3p BRWD3 -0.63 0 0.1 0.5367 MirTarget; miRNATAP -0.22 0.00248 NA
20 hsa-miR-22-3p BSPRY -0.63 0 -0.09 0.79035 MirTarget -0.86 0 NA
21 hsa-miR-22-3p BTBD10 -0.63 0 0.28 2.0E-5 MirTarget; miRNATAP -0.15 0 NA
22 hsa-miR-22-3p BTF3 -0.63 0 0.14 0.09744 miRNAWalker2 validate -0.11 0.00766 NA
23 hsa-miR-22-3p BUB1B -0.63 0 3.86 0 miRNAWalker2 validate -1.6 0 NA
24 hsa-miR-22-3p C17orf58 -0.63 0 0.66 0 miRNATAP -0.17 0.00135 NA
25 hsa-miR-22-3p C20orf194 -0.63 0 0.24 0.07938 mirMAP -0.28 1.0E-5 NA
26 hsa-miR-22-3p CBFA2T2 -0.63 0 1.21 0 mirMAP -0.53 0 NA
27 hsa-miR-22-3p CBL -0.63 0 0.05 0.65471 MirTarget -0.29 0 NA
28 hsa-miR-22-3p CBX6 -0.63 0 -0.14 0.56236 MirTarget -0.47 1.0E-5 NA
29 hsa-miR-22-3p CCNA2 -0.63 0 3.37 0 MirTarget -1.22 0 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers
30 hsa-miR-22-3p CCNT2 -0.63 0 -0.13 0.25328 miRNAWalker2 validate -0.13 0.01181 NA
31 hsa-miR-22-3p CDCA7L -0.63 0 0.48 0.01422 MirTarget -0.66 0 NA
32 hsa-miR-22-3p CLIP2 -0.63 0 0.62 0.00364 MirTarget -0.36 0.00029 NA
33 hsa-miR-22-3p COPS7B -0.63 0 0.64 0 MirTarget; miRNATAP -0.34 0 NA
34 hsa-miR-22-3p CREB1 -0.63 0 -0.01 0.8838 MirTarget -0.21 0 NA
35 hsa-miR-22-3p CSMD2 -0.63 0 2.32 0 MirTarget -0.45 0.00633 NA
36 hsa-miR-22-3p CSNK2A1 -0.63 0 0.31 6.0E-5 miRNAWalker2 validate -0.31 0 NA
37 hsa-miR-22-3p CTSC -0.63 0 0.24 0.17137 miRNATAP -0.3 0.00023 NA
38 hsa-miR-22-3p DAGLA -0.63 0 1.16 1.0E-5 MirTarget -0.6 0 NA
39 hsa-miR-22-3p DIDO1 -0.63 0 0.25 0.00079 mirMAP -0.2 0 NA
40 hsa-miR-22-3p DNAJC5 -0.63 0 0.73 0 MirTarget -0.28 0 NA
41 hsa-miR-22-3p DPF2 -0.63 0 0.62 0 MirTarget; miRNATAP -0.29 0 NA
42 hsa-miR-22-3p DPM2 -0.63 0 0.58 0 MirTarget -0.24 1.0E-5 NA
43 hsa-miR-22-3p DSTYK -0.63 0 1.01 0 MirTarget -0.27 0 NA
44 hsa-miR-22-3p E2F2 -0.63 0 2.82 0 miRNAWalker2 validate -1.18 0 NA
45 hsa-miR-22-3p EDARADD -0.63 0 0.94 4.0E-5 MirTarget -0.45 2.0E-5 NA
46 hsa-miR-22-3p EDC3 -0.63 0 0.73 0 miRNAWalker2 validate; MirTarget -0.32 0 NA
47 hsa-miR-22-3p EFR3B -0.63 0 0.42 0.00614 MirTarget -0.22 0.00208 NA
48 hsa-miR-22-3p ENO1 -0.63 0 0.29 0.02864 MirTarget -0.17 0.0055 NA
49 hsa-miR-22-3p EP300 -0.63 0 -0.2 0.07049 MirTarget; miRNATAP -0.1 0.04632 NA
50 hsa-miR-22-3p ERBB3 -0.63 0 0.58 0.00109 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.46 0 22484852; 22510010; 21057539; 27569217 Tumor suppressor miR 22 suppresses lung cancer cell progression through post transcriptional regulation of ErbB3; Furthermore miR-22 was demonstrated to inhibit the expression of ErbB3 through post-transcriptional regulation via binding to ErbB3 3'-UTR; miR-22 exhibited excellent anti-lung cancer activity in vitro and in vivo and post-transcriptional regulation of ErbB3 might be a potential mechanism;Transfected miR-22 Y79 cells inhibited the cell proliferation and reduced the migration and erythoblastic leukemia viral oncogene homolog 3 Erbb3 was confirmed to be the target gene of miR-22;These metastatic cells expressed higher levels of putative/proven miR-22 target oncogenes ERBB3 CDC25C and EVI-1; Introduction of miR-22 into cancer cells reduced the levels of ERBB3 and EVI-1 as well as phospho-AKT an EVI-1 downstream target;Finally we demonstrated the ability of miR-22 to intercept and overcome the intrinsic resistance to MEK inhibition based on ERBB3 upregulation
51 hsa-miR-22-3p FAM49B -0.63 0 0.71 0 MirTarget; miRNATAP -0.51 0 NA
52 hsa-miR-22-3p FAM53C -0.63 0 0.38 0 MirTarget; miRNATAP -0.14 2.0E-5 NA
53 hsa-miR-22-3p FBRS -0.63 0 0.35 0 miRNATAP -0.16 0 NA
54 hsa-miR-22-3p FBXL19 -0.63 0 1.09 0 miRNATAP -0.49 0 NA
55 hsa-miR-22-3p FGD6 -0.63 0 0.31 0.04392 MirTarget -0.36 0 NA
56 hsa-miR-22-3p FIBCD1 -0.63 0 1.89 0 MirTarget -0.62 0.00031 NA
57 hsa-miR-22-3p FMNL2 -0.63 0 0.05 0.80772 MirTarget -0.34 0.00061 NA
58 hsa-miR-22-3p FOXP1 -0.63 0 0.13 0.18315 miRNAWalker2 validate; miRNATAP -0.14 0.00251 NA
59 hsa-miR-22-3p FRAT2 -0.63 0 0.23 0.05124 miRNAWalker2 validate; MirTarget; miRNATAP -0.23 1.0E-5 NA
60 hsa-miR-22-3p FUBP1 -0.63 0 0.25 0.02191 miRNAWalker2 validate -0.36 0 NA
61 hsa-miR-22-3p GALNT4 -0.63 0 -0.65 0 MirTarget -0.18 0.0015 NA
62 hsa-miR-22-3p GIGYF2 -0.63 0 -0.02 0.78691 MirTarget -0.13 1.0E-5 NA
63 hsa-miR-22-3p GLIS2 -0.63 0 0.56 0.01316 miRNAWalker2 validate -0.6 0 NA
64 hsa-miR-22-3p GMEB2 -0.63 0 0.65 0 mirMAP -0.26 0 NA
65 hsa-miR-22-3p GNA12 -0.63 0 0.6 0 mirMAP -0.11 0.01718 NA
66 hsa-miR-22-3p GNB1L -0.63 0 0.97 0 mirMAP -0.25 4.0E-5 NA
67 hsa-miR-22-3p GPBP1 -0.63 0 0.37 0 MirTarget; miRNATAP -0.14 0 NA
68 hsa-miR-22-3p GPSM2 -0.63 0 1.45 0 MirTarget -0.82 0 NA
69 hsa-miR-22-3p H3F3B -0.63 0 0.01 0.92585 miRNAWalker2 validate; MirTarget -0.17 0 NA
70 hsa-miR-22-3p H3F3C -0.63 0 -0.33 0.00085 MirTarget -0.11 0.0142 NA
71 hsa-miR-22-3p HDAC4 -0.63 0 1.01 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.39 0 20842113 Furthermore histone deacetylase 4 HDAC4 known to have critical roles in cancer development was proved to be directly targeted and regulated by miR-22; Furthermore HDAC4 was upregulated in miR-22-downregulated HCC tissues suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression
72 hsa-miR-22-3p HES2 -0.63 0 1.81 0 mirMAP -0.59 0.0001 NA
73 hsa-miR-22-3p HIF1AN -0.63 0 0.59 0 MirTarget -0.22 0 NA
74 hsa-miR-22-3p HNF4G -0.63 0 -0.51 0.00622 MirTarget -0.32 0.00019 NA
75 hsa-miR-22-3p HNRNPH1 -0.63 0 0.42 0 miRNATAP -0.33 0 NA
76 hsa-miR-22-3p HNRNPUL2 -0.63 0 0.28 0 miRNATAP -0.11 5.0E-5 NA
77 hsa-miR-22-3p HOMER1 -0.63 0 -0.08 0.79615 MirTarget -0.52 0.00013 NA
78 hsa-miR-22-3p HSF2BP -0.63 0 2.11 0 MirTarget -0.97 0 NA
79 hsa-miR-22-3p HSPA1B -0.63 0 0.5 0.01779 miRNAWalker2 validate -0.3 0.00219 NA
80 hsa-miR-22-3p HTR3A -0.63 0 0.75 0.03159 MirTarget -0.6 0.00019 NA
81 hsa-miR-22-3p HUNK -0.63 0 -0.72 0.05314 MirTarget -0.97 0 NA
82 hsa-miR-22-3p IKZF4 -0.63 0 0.32 0.00089 MirTarget; miRNATAP -0.23 0 NA
83 hsa-miR-22-3p IL17RD -0.63 0 -0.13 0.6098 MirTarget; miRNATAP -0.3 0.00842 NA
84 hsa-miR-22-3p IL27RA -0.63 0 0.52 0.00116 MirTarget -0.35 0 NA
85 hsa-miR-22-3p IPO7 -0.63 0 -0.13 0.12689 MirTarget; miRNATAP -0.18 0 NA
86 hsa-miR-22-3p IRF5 -0.63 0 0.55 0 miRNAWalker2 validate -0.17 0.00212 NA
87 hsa-miR-22-3p ISY1 -0.63 0 0.2 0.00017 mirMAP -0.18 0 NA
88 hsa-miR-22-3p JARID2 -0.63 0 0.39 3.0E-5 miRNATAP -0.36 0 NA
89 hsa-miR-22-3p KCTD10 -0.63 0 0.32 0 MirTarget -0.15 0 NA
90 hsa-miR-22-3p KDM3A -0.63 0 0.26 0.00489 MirTarget; miRNATAP -0.3 0 NA
91 hsa-miR-22-3p KIAA1257 -0.63 0 0.43 0.10986 mirMAP -0.4 0.00137 NA
92 hsa-miR-22-3p KIF21B -0.63 0 1.18 0 mirMAP -0.22 0.04318 NA
93 hsa-miR-22-3p LAMC1 -0.63 0 1.18 0 MirTarget; miRNATAP -0.44 0 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs
94 hsa-miR-22-3p LEMD3 -0.63 0 -0.24 0.00152 miRNAWalker2 validate -0.11 0.00227 NA
95 hsa-miR-22-3p LIG3 -0.63 0 0.62 0 MirTarget -0.23 0 NA
96 hsa-miR-22-3p LRRC1 -0.63 0 2.14 0 miRNAWalker2 validate; miRNATAP -1.34 0 NA
97 hsa-miR-22-3p LRRC14 -0.63 0 1.37 0 mirMAP -0.34 0 NA
98 hsa-miR-22-3p LRRC59 -0.63 0 0.44 0 MirTarget -0.16 1.0E-5 NA
99 hsa-miR-22-3p MAP3K3 -0.63 0 0.01 0.88843 MirTarget; miRNATAP -0.1 0.00322 NA
100 hsa-miR-22-3p MAPK8IP3 -0.63 0 1.01 0 MirTarget -0.31 0 NA
101 hsa-miR-22-3p MAT2A -0.63 0 -0.01 0.92186 MirTarget; miRNATAP -0.15 0.00115 NA
102 hsa-miR-22-3p MDC1 -0.63 0 0.59 0 MirTarget -0.42 0 NA
103 hsa-miR-22-3p MECOM -0.63 0 0.96 0 miRNATAP -0.18 0.03306 NA
104 hsa-miR-22-3p MECP2 -0.63 0 0.26 0.00043 miRNATAP -0.14 4.0E-5 NA
105 hsa-miR-22-3p MED22 -0.63 0 0.9 0 mirMAP -0.42 0 NA
106 hsa-miR-22-3p MEIS2 -0.63 0 0.16 0.32841 MirTarget -0.23 0.00193 NA
107 hsa-miR-22-3p MFGE8 -0.63 0 0.98 0 MirTarget -0.24 0.00194 NA
108 hsa-miR-22-3p MTF2 -0.63 0 0.17 0.07103 MirTarget; miRNATAP -0.42 0 NA
109 hsa-miR-22-3p MTMR2 -0.63 0 0.4 0.001 MirTarget -0.49 0 NA
110 hsa-miR-22-3p MURC -0.63 0 1.58 0 MirTarget -0.37 6.0E-5 NA
111 hsa-miR-22-3p MXD1 -0.63 0 -0.23 0.05533 miRNATAP -0.18 0.00079 NA
112 hsa-miR-22-3p MYCBP -0.63 0 0.27 0.00288 miRNAWalker2 validate; miRTarBase -0.17 8.0E-5 NA
113 hsa-miR-22-3p MYO6 -0.63 0 -0.01 0.93833 miRNAWalker2 validate -0.17 0.00684 NA
114 hsa-miR-22-3p N4BP3 -0.63 0 1.82 0 MirTarget -0.61 0 NA
115 hsa-miR-22-3p NET1 -0.63 0 -0.26 0.0069 MirTarget; miRNATAP -0.15 0.00068 NA
116 hsa-miR-22-3p NHP2 -0.63 0 0.77 0 MirTarget -0.12 0.0246 NA
117 hsa-miR-22-3p NPNT -0.63 0 0.53 0.0583 miRNATAP -0.59 1.0E-5 NA
118 hsa-miR-22-3p NRAS -0.63 0 0.3 0.00029 MirTarget; miRNATAP -0.29 0 NA
119 hsa-miR-22-3p NUP210 -0.63 0 0.78 0 MirTarget -0.54 0 NA
120 hsa-miR-22-3p NUP214 -0.63 0 0.17 0.00488 miRNAWalker2 validate -0.12 4.0E-5 20081105 In addition to these specific effects reversing the expression of mir-22 and the putative oncogene mir-182 had widespread effects on target and nontarget gene populations that ultimately caused a global shift in the cancer gene signature toward a more normal state
121 hsa-miR-22-3p NUSAP1 -0.63 0 2.13 0 MirTarget -1.02 0 NA
122 hsa-miR-22-3p ORAI2 -0.63 0 0.15 0.33665 mirMAP -0.28 9.0E-5 NA
123 hsa-miR-22-3p OTUD6B -0.63 0 0.72 0 MirTarget -0.2 9.0E-5 NA
124 hsa-miR-22-3p PACS2 -0.63 0 0.78 0 mirMAP -0.21 0 NA
125 hsa-miR-22-3p PHC1 -0.63 0 -0.35 0.02268 MirTarget -0.19 0.00881 NA
126 hsa-miR-22-3p PIK3R6 -0.63 0 0.97 0 MirTarget -0.38 1.0E-5 NA
127 hsa-miR-22-3p PIP4K2B -0.63 0 0.58 0 MirTarget -0.28 0 NA
128 hsa-miR-22-3p PLAGL2 -0.63 0 0.34 0.003 miRNATAP -0.49 0 NA
129 hsa-miR-22-3p PLEKHA6 -0.63 0 -0.15 0.29725 MirTarget -0.14 0.03513 NA
130 hsa-miR-22-3p PLEKHG4B -0.63 0 0.79 0.03377 mirMAP -0.39 0.02379 NA
131 hsa-miR-22-3p PMAIP1 -0.63 0 -0.75 0.00471 MirTarget -0.38 0.00196 NA
132 hsa-miR-22-3p POGK -0.63 0 0.63 0 MirTarget -0.45 0 NA
133 hsa-miR-22-3p PRDM4 -0.63 0 0.27 0.00011 MirTarget -0.24 0 NA
134 hsa-miR-22-3p PRPF38A -0.63 0 0.13 0.06066 MirTarget -0.32 0 NA
135 hsa-miR-22-3p PRRT2 -0.63 0 1.35 0 miRNATAP -0.59 0 NA
136 hsa-miR-22-3p PRX -0.63 0 0.97 0 mirMAP -0.36 0 NA
137 hsa-miR-22-3p PTP4A3 -0.63 0 1.98 0 MirTarget -0.73 0 NA
138 hsa-miR-22-3p PTPN1 -0.63 0 0.12 0.12184 miRNATAP -0.11 0.00191 NA
139 hsa-miR-22-3p PURB -0.63 0 0.17 0.00583 miRNATAP -0.2 0 NA
140 hsa-miR-22-3p RAB11FIP4 -0.63 0 1.54 0 miRNATAP -0.61 0 NA
141 hsa-miR-22-3p RAPGEFL1 -0.63 0 0.51 0.0061 miRNATAP -0.52 0 NA
142 hsa-miR-22-3p RBM33 -0.63 0 0.43 0 mirMAP -0.17 0 NA
143 hsa-miR-22-3p RBM39 -0.63 0 0.35 0 miRNAWalker2 validate -0.17 0 NA
144 hsa-miR-22-3p RCC2 -0.63 0 0.69 0 MirTarget -0.6 0 NA
145 hsa-miR-22-3p RFXANK -0.63 0 1.01 0 MirTarget -0.35 0 NA
146 hsa-miR-22-3p RNF38 -0.63 0 -0.08 0.42663 miRNATAP -0.2 0 NA
147 hsa-miR-22-3p RPL24 -0.63 0 0.12 0.31552 miRNAWalker2 validate -0.15 0.00627 NA
148 hsa-miR-22-3p RPL35A -0.63 0 0.4 0.00057 miRNAWalker2 validate -0.29 0 NA
149 hsa-miR-22-3p RPS2 -0.63 0 0.39 0.00217 miRNAWalker2 validate -0.32 0 NA
150 hsa-miR-22-3p RPS4X -0.63 0 0.17 0.13378 miRNAWalker2 validate -0.25 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 29 1199 9.068e-06 0.004212
2 POLY A RNA BINDING 29 1170 5.681e-06 0.004212
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04520_Adherens_junction 5 73 0.0008235 0.1482
2 hsa03010_Ribosome 5 92 0.002315 0.2083
3 hsa04722_Neurotrophin_signaling_pathway 5 127 0.009051 0.3768
4 hsa04110_Cell_cycle 5 128 0.009345 0.3768
5 hsa04350_TGF.beta_signaling_pathway 4 85 0.01047 0.3768
6 hsa04144_Endocytosis 6 203 0.01655 0.4966
7 hsa00512_Mucin_type_O.Glycan_biosynthesis 2 30 0.03603 0.888
8 hsa04612_Antigen_processing_and_presentation 3 78 0.0434 0.888
9 hsa03008_Ribosome_biogenesis_in_eukaryotes 3 81 0.04764 0.888
10 hsa04010_MAPK_signaling_pathway 6 268 0.05299 0.888
11 hsa04012_ErbB_signaling_pathway 3 87 0.05671 0.888
12 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.06418 0.888
13 hsa04310_Wnt_signaling_pathway 4 151 0.06524 0.888
14 hsa04390_Hippo_signaling_pathway 4 154 0.06907 0.888
15 hsa04916_Melanogenesis 3 101 0.08075 0.969
16 hsa03040_Spliceosome 3 128 0.1369 1
17 hsa04530_Tight_junction 3 133 0.1485 1
18 hsa04115_p53_signaling_pathway 2 69 0.1516 1
19 hsa04720_Long.term_potentiation 2 70 0.1551 1
20 hsa04730_Long.term_depression 2 70 0.1551 1
21 hsa03018_RNA_degradation 2 71 0.1586 1
22 hsa04976_Bile_secretion 2 71 0.1586 1
23 hsa04910_Insulin_signaling_pathway 3 138 0.1604 1
24 hsa04260_Cardiac_muscle_contraction 2 77 0.1799 1
25 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.2457 1
26 hsa04912_GnRH_signaling_pathway 2 101 0.2679 1
27 hsa04151_PI3K_AKT_signaling_pathway 5 351 0.2751 1
28 hsa04660_T_cell_receptor_signaling_pathway 2 108 0.2939 1
29 hsa04380_Osteoclast_differentiation 2 128 0.3669 1
30 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.4058 1
31 hsa03013_RNA_transport 2 152 0.4504 1
32 hsa04630_Jak.STAT_signaling_pathway 2 155 0.4604 1
33 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.5025 1
34 hsa04510_Focal_adhesion 2 200 0.5967 1

Quest ID: dfa9cb9730958081ed21a10e4c49a83d