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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p APC2 -1.37 0 1.14 0.00012 TargetScan -0.46 0 NA
2 hsa-miR-15b-3p CAMK2A 0.8 0.0004 -1.98 0 mirMAP -0.33 0 NA
3 hsa-miR-19b-1-5p CAMK2A 1.71 0 -1.98 0 mirMAP -0.34 0 NA
4 hsa-miR-21-3p CAMK2A 2.54 0 -1.98 0 MirTarget -0.32 0 NA
5 hsa-miR-25-3p CAMK2A 0.36 0.01637 -1.98 0 MirTarget -0.43 1.0E-5 NA
6 hsa-miR-7-1-3p CAMK2A 2.61 0 -1.98 0 MirTarget -0.32 0 NA
7 hsa-miR-29a-3p CAMK2B 0.1 0.5732 1.37 0.0148 mirMAP -0.57 8.0E-5 NA
8 hsa-miR-15b-5p CCND1 -1.26 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.3 0 NA
9 hsa-miR-16-5p CCND1 0.75 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.37 0 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
10 hsa-miR-17-5p CCND1 2.07 0 -0.3 0.2554 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.31 0 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene
11 hsa-miR-186-5p CCND1 0.85 0 -0.3 0.2554 mirMAP -0.38 1.0E-5 NA
12 hsa-miR-19b-1-5p CCND1 1.71 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase -0.3 0 NA
13 hsa-miR-374a-5p CCND1 -0.2 0.29808 -0.3 0.2554 MirTarget -0.31 1.0E-5 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression
14 hsa-miR-92a-3p CCND1 -0.14 0.49341 -0.3 0.2554 miRNAWalker2 validate -0.34 0 NA
15 hsa-miR-93-5p CCND1 1.51 0 -0.3 0.2554 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 0 NA
16 hsa-miR-106b-5p CCND2 1.47 0 -1.64 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.38 0 NA
17 hsa-miR-17-5p CCND2 2.07 0 -1.64 0 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.37 0 NA
18 hsa-miR-182-5p CCND2 3.22 0 -1.64 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0 NA
19 hsa-miR-183-5p CCND2 2.39 0 -1.64 0 miRNATAP -0.41 0 NA
20 hsa-miR-186-5p CCND2 0.85 0 -1.64 0 mirMAP; miRNATAP -0.36 1.0E-5 NA
21 hsa-miR-93-5p CCND2 1.51 0 -1.64 0 miRNATAP -0.41 0 NA
22 hsa-miR-96-5p CCND2 3.04 0 -1.64 0 TargetScan; miRNATAP -0.36 0 NA
23 hsa-miR-146a-5p CXXC4 0.68 0.01053 0.06 0.89857 MirTarget -0.35 1.0E-5 NA
24 hsa-miR-146b-5p CXXC4 1.09 1.0E-5 0.06 0.89857 MirTarget; miRNATAP -0.46 0 NA
25 hsa-miR-193a-3p DAAM2 0.55 0.0319 -1.64 0 miRanda -0.32 0 NA
26 hsa-miR-421 DAAM2 0.17 0.53528 -1.64 0 PITA; miRanda -0.39 0 NA
27 hsa-miR-590-3p DAAM2 0.84 0.00129 -1.64 0 miRanda; mirMAP -0.39 0 NA
28 hsa-miR-324-5p DKK2 1.07 5.0E-5 -2.46 0 miRanda -0.32 0 NA
29 hsa-miR-590-5p DKK2 2.07 0 -2.46 0 miRanda -0.43 0 NA
30 hsa-miR-429 FOSL1 2.38 0 -0.17 0.70192 miRanda; miRNATAP -0.3 0 NA
31 hsa-miR-186-5p FZD1 0.85 0 -0.36 0.09979 mirMAP -0.33 1.0E-5 NA
32 hsa-miR-23a-3p FZD3 0.11 0.39309 0.79 0.00088 MirTarget -0.35 5.0E-5 NA
33 hsa-miR-361-5p FZD3 0.21 0.0801 0.79 0.00088 miRanda; miRNATAP -0.34 0.00018 NA
34 hsa-miR-130b-3p MAPK10 1.83 0 -1.85 0 miRNATAP -0.54 0 NA
35 hsa-miR-590-3p MAPK10 0.84 0.00129 -1.85 0 miRanda; mirMAP -0.49 0 NA
36 hsa-miR-590-5p MAPK10 2.07 0 -1.85 0 PITA; miRanda; miRNATAP -0.56 0 NA
37 hsa-miR-185-5p NFATC2 1.14 0 -1.18 0.0004 MirTarget -0.36 0.00019 NA
38 hsa-miR-186-5p NFATC2 0.85 0 -1.18 0.0004 mirMAP -0.34 0.00202 NA
39 hsa-miR-19a-3p NFATC2 2.12 0 -1.18 0.0004 mirMAP -0.34 0 NA
40 hsa-miR-19b-3p NFATC2 2.11 0 -1.18 0.0004 mirMAP -0.38 0 NA
41 hsa-miR-21-5p NKD1 4.38 0 -1.73 0 mirMAP -0.39 0 NA
42 hsa-miR-140-3p PLCB1 -1.11 0 0.16 0.60449 PITA -0.39 2.0E-5 NA
43 hsa-miR-183-5p PLCB4 2.39 0 -1.83 7.0E-5 miRNATAP -0.32 6.0E-5 NA
44 hsa-miR-590-3p PLCB4 0.84 0.00129 -1.83 7.0E-5 miRanda -0.35 0.00036 NA
45 hsa-miR-96-5p PLCB4 3.04 0 -1.83 7.0E-5 TargetScan; miRNATAP -0.31 6.0E-5 NA
46 hsa-miR-141-3p PRICKLE1 3.37 0 -1.65 0 TargetScan -0.35 0 NA
47 hsa-miR-17-5p PRICKLE1 2.07 0 -1.65 0 miRNAWalker2 validate -0.37 0 NA
48 hsa-miR-148b-3p PRICKLE2 0.48 0.00265 -1.56 0 MirTarget; miRNATAP -0.35 0 NA
49 hsa-miR-590-5p PRICKLE2 2.07 0 -1.56 0 MirTarget; PITA; miRanda -0.34 0 NA
50 hsa-miR-181c-5p PRKCA 0.53 0.01259 -0.19 0.47108 mirMAP -0.33 0 NA
51 hsa-miR-2110 PRKCG -1.92 0 1.67 0.00027 MirTarget -0.31 6.0E-5 NA
52 hsa-miR-30c-2-3p RAC3 -3.11 0 1.83 0 miRNAWalker2 validate -0.37 0 NA
53 hsa-miR-146b-5p SFRP1 1.09 1.0E-5 -2.09 5.0E-5 MirTarget -0.53 0 NA
54 hsa-miR-16-1-3p SFRP1 1.5 0 -2.09 5.0E-5 MirTarget -0.48 6.0E-5 NA
55 hsa-miR-29a-5p SFRP1 1.9 0 -2.09 5.0E-5 mirMAP -0.55 0 NA
56 hsa-miR-96-5p SFRP1 3.04 0 -2.09 5.0E-5 mirMAP -0.38 2.0E-5 NA
57 hsa-miR-26b-5p SFRP4 0.72 5.0E-5 0.5 0.21527 miRNAWalker2 validate -0.31 0.00346 NA
58 hsa-miR-127-5p WIF1 2.05 0 -5.68 0 PITA; miRNATAP -0.49 0 NA
59 hsa-miR-28-5p WIF1 1.2 0 -5.68 0 miRanda -0.75 0.00387 NA
60 hsa-miR-590-3p WIF1 0.84 0.00129 -5.68 0 PITA; miRanda; mirMAP -0.52 0.00196 NA
61 hsa-miR-590-3p WNT11 0.84 0.00129 -2.02 0 miRanda -0.37 1.0E-5 NA
62 hsa-miR-181a-5p WNT16 -0.38 0.05621 0.42 0.38122 miRNAWalker2 validate; MirTarget -0.42 0.00021 NA
63 hsa-miR-181b-5p WNT16 0.67 0.00024 0.42 0.38122 MirTarget -0.4 0.00092 NA
64 hsa-miR-335-3p WNT2 1.51 0 -1.62 0 mirMAP -0.42 0 NA
65 hsa-miR-130b-3p WNT2B 1.83 0 -1.79 0 MirTarget -0.34 0 NA
66 hsa-miR-107 WNT3A 0.66 0 -5.45 0 MirTarget; PITA; miRanda; miRNATAP -0.6 0.00204 NA
67 hsa-miR-128-3p WNT3A 1.04 0 -5.45 0 miRNAWalker2 validate -0.73 0 27341528 AurkA controls self renewal of breast cancer initiating cells promoting wnt3a stabilization through suppression of miR 128; Interestingly we found that AurkA suppressed the expression of miR-128 inhibitor of wnt3a mRNA stabilization
68 hsa-miR-16-2-3p WNT5A 0.5 0.02636 -0.37 0.19306 MirTarget; mirMAP -0.37 0 NA
69 hsa-miR-186-5p WNT5A 0.85 0 -0.37 0.19306 miRNAWalker2 validate; mirMAP; miRNATAP -0.42 1.0E-5 NA
70 hsa-miR-576-5p WNT5A 1.03 0 -0.37 0.19306 mirMAP -0.4 0 NA
71 hsa-miR-92a-3p WNT5A -0.14 0.49341 -0.37 0.19306 miRNAWalker2 validate -0.36 0 NA
72 hsa-miR-107 WNT7A 0.66 0 -4.45 0 MirTarget; miRanda -1.04 1.0E-5 NA
73 hsa-miR-16-5p WNT7A 0.75 0 -4.45 0 MirTarget -0.55 0.00371 NA
74 hsa-miR-28-5p WNT9A 1.2 0 -1.71 0 mirMAP -0.41 3.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 22 351 6.729e-32 3.131e-28
2 REGULATION OF WNT SIGNALING PATHWAY 16 310 3.622e-21 8.427e-18
3 CANONICAL WNT SIGNALING PATHWAY 11 95 1.816e-18 2.816e-15
4 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 13 236 1.757e-17 2.044e-14
5 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 12 197 1.131e-16 1.052e-13
6 NON CANONICAL WNT SIGNALING PATHWAY 11 140 1.509e-16 1.17e-13
7 REGULATION OF ORGAN MORPHOGENESIS 11 242 6.687e-14 4.445e-11
8 REGULATION OF EMBRYONIC DEVELOPMENT 9 114 1.158e-13 6.733e-11
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 3.633e-13 1.878e-10
10 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 16 1021 5.267e-13 2.451e-10
11 REGULATION OF CELL DIFFERENTIATION 18 1492 7.968e-13 3.37e-10
12 CELL FATE COMMITMENT 10 227 1.508e-12 5.761e-10
13 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 9 152 1.609e-12 5.761e-10
14 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 162 2.869e-12 9.023e-10
15 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 16 1142 2.909e-12 9.023e-10
16 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 8 110 6.094e-12 1.772e-09
17 POSITIVE REGULATION OF CELL DIFFERENTIATION 13 823 1.486e-10 4.066e-08
18 NEURON DIFFERENTIATION 13 874 3.115e-10 8.053e-08
19 EMBRYO DEVELOPMENT 13 894 4.113e-10 1.007e-07
20 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 119 6.573e-10 1.529e-07
21 POSITIVE REGULATION OF RESPONSE TO STIMULUS 17 1929 6.954e-10 1.53e-07
22 DOPAMINERGIC NEURON DIFFERENTIATION 5 28 7.236e-10 1.53e-07
23 POSITIVE REGULATION OF CELL COMMUNICATION 15 1532 2.784e-09 5.632e-07
24 ORGAN MORPHOGENESIS 12 841 2.935e-09 5.654e-07
25 SENSORY ORGAN MORPHOGENESIS 8 239 3.038e-09 5.654e-07
26 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 4.008e-09 7.172e-07
27 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 5 39 4.187e-09 7.215e-07
28 MIDBRAIN DEVELOPMENT 6 90 5.784e-09 9.611e-07
29 TISSUE MORPHOGENESIS 10 533 6.326e-09 1.015e-06
30 EMBRYONIC MORPHOGENESIS 10 539 7.038e-09 1.092e-06
31 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 10 554 9.142e-09 1.3e-06
32 MORPHOGENESIS OF AN EPITHELIUM 9 400 8.739e-09 1.3e-06
33 NEUROGENESIS 14 1402 9.217e-09 1.3e-06
34 NEGATIVE REGULATION OF CELL COMMUNICATION 13 1192 1.344e-08 1.84e-06
35 STEM CELL DIFFERENTIATION 7 190 1.721e-08 2.288e-06
36 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 14 1492 2.04e-08 2.636e-06
37 EPITHELIAL TO MESENCHYMAL TRANSITION 5 56 2.725e-08 3.427e-06
38 SENSORY ORGAN DEVELOPMENT 9 493 5.291e-08 6.479e-06
39 CELLULAR RESPONSE TO RETINOIC ACID 5 65 5.833e-08 6.959e-06
40 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 6 134 6.348e-08 7.301e-06
41 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 13 1360 6.433e-08 7.301e-06
42 EYE MORPHOGENESIS 6 136 6.934e-08 7.682e-06
43 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 1135 8.244e-08 8.718e-06
44 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 8 365 8.178e-08 8.718e-06
45 HEAD DEVELOPMENT 10 709 9.359e-08 9.467e-06
46 AXIS ELONGATION 4 27 9.228e-08 9.467e-06
47 REGULATION OF PROTEIN MODIFICATION PROCESS 14 1710 1.14e-07 1.128e-05
48 NEURAL TUBE DEVELOPMENT 6 149 1.194e-07 1.157e-05
49 EPITHELIUM DEVELOPMENT 11 945 1.279e-07 1.214e-05
50 TUBE DEVELOPMENT 9 552 1.386e-07 1.29e-05
51 REGULATION OF CELL DEATH 13 1472 1.627e-07 1.485e-05
52 REGULATION OF ORGAN FORMATION 4 32 1.88e-07 1.683e-05
53 CELL CELL SIGNALING 10 767 1.945e-07 1.693e-05
54 REGULATION OF CELL PROLIFERATION 13 1496 1.965e-07 1.693e-05
55 POSITIVE REGULATION OF MOLECULAR FUNCTION 14 1791 2.029e-07 1.716e-05
56 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 4 33 2.137e-07 1.776e-05
57 PALATE DEVELOPMENT 5 85 2.265e-07 1.817e-05
58 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 6 166 2.263e-07 1.817e-05
59 PATTERN SPECIFICATION PROCESS 8 418 2.307e-07 1.82e-05
60 CARDIOVASCULAR SYSTEM DEVELOPMENT 10 788 2.497e-07 1.905e-05
61 CIRCULATORY SYSTEM DEVELOPMENT 10 788 2.497e-07 1.905e-05
62 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 2.75e-07 2.064e-05
63 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 10 801 2.905e-07 2.146e-05
64 CELLULAR RESPONSE TO ACID CHEMICAL 6 175 3.09e-07 2.247e-05
65 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 11 1036 3.226e-07 2.274e-05
66 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 11 1036 3.226e-07 2.274e-05
67 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 3.37e-07 2.34e-05
68 NEURAL TUBE FORMATION 5 94 3.752e-07 2.567e-05
69 MESENCHYME DEVELOPMENT 6 190 5.012e-07 3.38e-05
70 CAMERA TYPE EYE MORPHOGENESIS 5 101 5.371e-07 3.57e-05
71 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 11 6.086e-07 3.988e-05
72 TUBE MORPHOGENESIS 7 323 6.389e-07 4.073e-05
73 CENTRAL NERVOUS SYSTEM DEVELOPMENT 10 872 6.341e-07 4.073e-05
74 EYE DEVELOPMENT 7 326 6.798e-07 4.275e-05
75 RESPONSE TO OXYGEN CONTAINING COMPOUND 12 1381 6.904e-07 4.283e-05
76 RESPONSE TO RETINOIC ACID 5 107 7.16e-07 4.384e-05
77 CELL PROLIFERATION 9 672 7.255e-07 4.384e-05
78 RESPONSE TO LIPID 10 888 7.488e-07 4.467e-05
79 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 7.69e-07 4.53e-05
80 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 1152 9.276e-07 5.395e-05
81 HEART MORPHOGENESIS 6 212 9.515e-07 5.466e-05
82 POSITIVE REGULATION OF GENE EXPRESSION 13 1733 1.07e-06 6.072e-05
83 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 513 1.085e-06 6.082e-05
84 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 3 14 1.338e-06 7.325e-05
85 CONVERGENT EXTENSION 3 14 1.338e-06 7.325e-05
86 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 6 228 1.453e-06 7.864e-05
87 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 10 957 1.479e-06 7.908e-05
88 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 4 53 1.496e-06 7.908e-05
89 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 750 1.804e-06 9.349e-05
90 TUBE FORMATION 5 129 1.808e-06 9.349e-05
91 TISSUE DEVELOPMENT 12 1518 1.886e-06 9.645e-05
92 PARAXIAL MESODERM DEVELOPMENT 3 16 2.054e-06 0.0001039
93 MESENCHYMAL CELL DIFFERENTIATION 5 134 2.181e-06 0.0001091
94 EMBRYONIC ORGAN DEVELOPMENT 7 406 2.929e-06 0.000145
95 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 9 799 3.036e-06 0.0001457
96 REPRODUCTIVE SYSTEM DEVELOPMENT 7 408 3.026e-06 0.0001457
97 POST ANAL TAIL MORPHOGENESIS 3 18 2.987e-06 0.0001457
98 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 19 3.543e-06 0.0001682
99 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 3.628e-06 0.0001705
100 REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 1618 3.685e-06 0.0001715
101 SYNAPSE ASSEMBLY 4 69 4.337e-06 0.0001998
102 NEURAL PRECURSOR CELL PROLIFERATION 4 70 4.595e-06 0.0002096
103 EMBRYONIC ORGAN MORPHOGENESIS 6 279 4.666e-06 0.0002108
104 REGULATION OF JNK CASCADE 5 159 5.048e-06 0.0002259
105 REGULATION OF DEVELOPMENTAL GROWTH 6 289 5.71e-06 0.000253
106 NEGATIVE REGULATION OF CELL DEATH 9 872 6.194e-06 0.0002719
107 CELLULAR RESPONSE TO LIPID 7 457 6.375e-06 0.0002772
108 SOMITE DEVELOPMENT 4 78 7.084e-06 0.0003052
109 HEART DEVELOPMENT 7 466 7.242e-06 0.0003091
110 CELLULAR COMPONENT MORPHOGENESIS 9 900 8e-06 0.0003384
111 REGIONALIZATION 6 311 8.683e-06 0.000364
112 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 4 84 9.518e-06 0.0003954
113 REGULATION OF CELLULAR RESPONSE TO STRESS 8 691 9.827e-06 0.0004046
114 RESPONSE TO ACID CHEMICAL 6 319 1.003e-05 0.0004096
115 REGULATION OF CATENIN IMPORT INTO NUCLEUS 3 27 1.06e-05 0.000429
116 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 12 1805 1.142e-05 0.0004516
117 REGULATION OF STEM CELL PROLIFERATION 4 88 1.145e-05 0.0004516
118 REGULATION OF TRANSPORT 12 1804 1.136e-05 0.0004516
119 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 1.186e-05 0.0004638
120 REGULATION OF CELL CYCLE 9 949 1.226e-05 0.0004753
121 AXIS SPECIFICATION 4 90 1.252e-05 0.0004802
122 POSITIVE REGULATION OF CELL CYCLE 6 332 1.259e-05 0.0004802
123 DORSAL VENTRAL PATTERN FORMATION 4 91 1.308e-05 0.0004949
124 POSITIVE REGULATION OF CATALYTIC ACTIVITY 11 1518 1.346e-05 0.0005051
125 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 337 1.37e-05 0.0005101
126 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 197 1.43e-05 0.0005279
127 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 12 1848 1.453e-05 0.0005323
128 FOREBRAIN DEVELOPMENT 6 357 1.899e-05 0.0006902
129 EMBRYONIC AXIS SPECIFICATION 3 33 1.965e-05 0.0007087
130 RESPONSE TO ALCOHOL 6 362 2.054e-05 0.000735
131 REGULATION OF MESENCHYMAL CELL PROLIFERATION 3 34 2.153e-05 0.0007588
132 BRAIN MORPHOGENESIS 3 34 2.153e-05 0.0007588
133 REGULATION OF CELLULAR COMPONENT MOVEMENT 8 771 2.172e-05 0.00076
134 CARDIAC CHAMBER MORPHOGENESIS 4 104 2.218e-05 0.0007645
135 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 4 104 2.218e-05 0.0007645
136 REGULATION OF FAT CELL DIFFERENTIATION 4 106 2.391e-05 0.000818
137 MESENCHYME MORPHOGENESIS 3 38 3.021e-05 0.001026
138 GLAND DEVELOPMENT 6 395 3.352e-05 0.00113
139 NEGATIVE REGULATION OF GROWTH 5 236 3.404e-05 0.00114
140 MAMMARY GLAND DEVELOPMENT 4 117 3.524e-05 0.001171
141 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 7 602 3.778e-05 0.001247
142 POSITIVE REGULATION OF CELL DEATH 7 605 3.899e-05 0.001269
143 REGULATION OF CELL DEVELOPMENT 8 836 3.877e-05 0.001269
144 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 3 42 4.094e-05 0.001314
145 NEGATIVE REGULATION OF CELL DIFFERENTIATION 7 609 4.066e-05 0.001314
146 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 3 43 4.396e-05 0.001401
147 OSTEOBLAST DIFFERENTIATION 4 126 4.711e-05 0.001491
148 CELL DEVELOPMENT 10 1426 4.963e-05 0.00156
149 REGULATION OF GROWTH 7 633 5.196e-05 0.001623
150 MUSCLE STRUCTURE DEVELOPMENT 6 432 5.52e-05 0.001712
151 NEGATIVE REGULATION OF LOCOMOTION 5 263 5.701e-05 0.001751
152 RESPONSE TO ENDOGENOUS STIMULUS 10 1450 5.721e-05 0.001751
153 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 5.884e-05 0.001789
154 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 3 48 6.128e-05 0.001811
155 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 135 6.165e-05 0.001811
156 RESPONSE TO HORMONE 8 893 6.187e-05 0.001811
157 DIGESTIVE TRACT MORPHOGENESIS 3 48 6.128e-05 0.001811
158 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 6.188e-05 0.001811
159 SEX DIFFERENTIATION 5 266 6.016e-05 0.001811
160 CARDIAC SEPTUM MORPHOGENESIS 3 49 6.52e-05 0.001896
161 REGULATION OF MAPK CASCADE 7 660 6.763e-05 0.001955
162 SKELETAL SYSTEM DEVELOPMENT 6 455 7.356e-05 0.002113
163 CARDIAC CHAMBER DEVELOPMENT 4 144 7.923e-05 0.002248
164 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 4 144 7.923e-05 0.002248
165 SYNAPSE ORGANIZATION 4 145 8.139e-05 0.002295
166 MAMMARY GLAND EPITHELIUM DEVELOPMENT 3 53 8.255e-05 0.002314
167 RESPONSE TO ESTRADIOL 4 146 8.359e-05 0.002322
168 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 10 1517 8.384e-05 0.002322
169 POSITIVE REGULATION OF MAPK CASCADE 6 470 8.796e-05 0.002384
170 VASCULATURE DEVELOPMENT 6 469 8.694e-05 0.002384
171 VENTRICULAR SEPTUM DEVELOPMENT 3 54 8.731e-05 0.002384
172 MALE SEX DIFFERENTIATION 4 148 8.812e-05 0.002384
173 POSITIVE REGULATION OF CELL DEVELOPMENT 6 472 9.004e-05 0.002422
174 PROTEIN PHOSPHORYLATION 8 944 9.138e-05 0.002444
175 REGULATION OF MUSCLE CELL DIFFERENTIATION 4 152 9.77e-05 0.002583
176 OUTFLOW TRACT MORPHOGENESIS 3 56 9.736e-05 0.002583
177 POSITIVE REGULATION OF KINASE ACTIVITY 6 482 0.000101 0.002656
178 GASTRULATION 4 155 0.0001054 0.002755
179 EMBRYONIC PATTERN SPECIFICATION 3 58 0.0001081 0.002811
180 RESPONSE TO CYTOKINE 7 714 0.0001107 0.002862
181 INTRACELLULAR SIGNAL TRANSDUCTION 10 1572 0.0001131 0.002906
182 STEM CELL PROLIFERATION 3 60 0.0001197 0.003059
183 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 8 983 0.0001212 0.003081
184 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.0001257 0.003179
185 SOMITOGENESIS 3 62 0.000132 0.003319
186 REGULATION OF CELL CELL ADHESION MEDIATED BY CADHERIN 2 11 0.0001352 0.003382
187 REGULATION OF CARTILAGE DEVELOPMENT 3 63 0.0001384 0.003444
188 NEGATIVE REGULATION OF CELL GROWTH 4 170 0.0001505 0.003724
189 FOREBRAIN GENERATION OF NEURONS 3 66 0.000159 0.003893
190 MESODERM MORPHOGENESIS 3 66 0.000159 0.003893
191 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 2 12 0.0001621 0.003907
192 EMBRYONIC CAMERA TYPE EYE FORMATION 2 12 0.0001621 0.003907
193 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 2 12 0.0001621 0.003907
194 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 3 67 0.0001663 0.003988
195 DEVELOPMENTAL GROWTH 5 333 0.0001728 0.004123
196 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0001737 0.004125
197 REGULATION OF KINASE ACTIVITY 7 776 0.0001855 0.004381
198 MUSCLE ORGAN MORPHOGENESIS 3 70 0.0001894 0.00445
199 HEMATOPOIETIC STEM CELL PROLIFERATION 2 13 0.0001913 0.004474
200 RESPONSE TO KETONE 4 182 0.0001955 0.004548
201 REGULATION OF CELL MORPHOGENESIS 6 552 0.0002115 0.004896
202 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 73 0.0002144 0.00494
203 REGULATION OF NEURON DIFFERENTIATION 6 554 0.0002157 0.004944
204 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 4 188 0.0002213 0.004989
205 POSITIVE REGULATION OF MEIOTIC CELL CYCLE 2 14 0.000223 0.004989
206 CELL MIGRATION INVOLVED IN GASTRULATION 2 14 0.000223 0.004989
207 REGULATION OF PROTEIN KINASE C SIGNALING 2 14 0.000223 0.004989
208 CELLULAR RESPONSE TO VITAMIN D 2 14 0.000223 0.004989
209 REGULATION OF BMP SIGNALING PATHWAY 3 77 0.0002511 0.005591
210 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0002645 0.005862
211 REGULATION OF ENDOCYTOSIS 4 199 0.0002749 0.006063
212 LOCOMOTION 8 1114 0.0002863 0.006284
213 REGULATION OF FIBROBLAST PROLIFERATION 3 81 0.0002916 0.006351
214 ORGAN INDUCTION 2 16 0.0002935 0.006351
215 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 2 16 0.0002935 0.006351
216 POSITIVE REGULATION OF CELL ADHESION 5 376 0.0003032 0.006531
217 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 84 0.0003246 0.006961
218 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 2 17 0.0003323 0.00706
219 ESTABLISHMENT OF TISSUE POLARITY 2 17 0.0003323 0.00706
220 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0003361 0.007077
221 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 85 0.0003361 0.007077
222 RESPONSE TO NITROGEN COMPOUND 7 859 0.0003452 0.007236
223 REGULATION OF RESPONSE TO STRESS 9 1468 0.0003599 0.00751
224 REGULATION OF PROTEIN CATABOLIC PROCESS 5 393 0.0003714 0.007688
225 NOTOCHORD DEVELOPMENT 2 18 0.0003734 0.007688
226 UTERUS DEVELOPMENT 2 18 0.0003734 0.007688
227 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 4 216 0.0003753 0.007693
228 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 6 616 0.0003811 0.007778
229 SEGMENTATION 3 89 0.0003848 0.007785
230 EPITHELIAL CELL PROLIFERATION 3 89 0.0003848 0.007785
231 RESPONSE TO ESTROGEN 4 218 0.0003886 0.007796
232 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 7 876 0.0003887 0.007796
233 NEGATIVE REGULATION OF GENE EXPRESSION 9 1493 0.0004079 0.008146
234 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 2 19 0.000417 0.008291
235 INNER EAR MORPHOGENESIS 3 92 0.0004242 0.008398
236 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 5 406 0.0004311 0.008499
237 GROWTH 5 410 0.0004508 0.00885
238 DORSAL VENTRAL AXIS SPECIFICATION 2 20 0.0004628 0.009048
239 POSITIVE REGULATION OF HYDROLASE ACTIVITY 7 905 0.000473 0.009209
240 NEGATIVE REGULATION OF CELL PROLIFERATION 6 643 0.0004787 0.009281
241 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 4 232 0.0004916 0.009491
242 RESPONSE TO ORGANIC CYCLIC COMPOUND 7 917 0.0005119 0.009763
243 RESPONSE TO VITAMIN 3 98 0.0005104 0.009763
244 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 98 0.0005104 0.009763
NumGOOverlapSizeP ValueAdj. P Value
1 FRIZZLED BINDING 10 36 5.674e-21 5.272e-18
2 G PROTEIN COUPLED RECEPTOR BINDING 10 259 5.6e-12 2.601e-09
3 WNT PROTEIN BINDING 5 31 1.247e-09 3.861e-07
4 RECEPTOR AGONIST ACTIVITY 4 16 9.689e-09 2.25e-06
5 WNT ACTIVATED RECEPTOR ACTIVITY 4 22 3.868e-08 7.187e-06
6 RECEPTOR ACTIVATOR ACTIVITY 4 32 1.88e-07 2.911e-05
7 RECEPTOR REGULATOR ACTIVITY 4 45 7.678e-07 0.0001019
8 RECEPTOR BINDING 11 1476 1.031e-05 0.001197
9 PDZ DOMAIN BINDING 4 90 1.252e-05 0.001292
10 SIGNAL TRANSDUCER ACTIVITY 11 1731 4.606e-05 0.004279
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEINACEOUS EXTRACELLULAR MATRIX 9 356 3.171e-09 1.852e-06
2 EXTRACELLULAR MATRIX 9 426 1.507e-08 4.401e-06
3 ENDOCYTIC VESICLE MEMBRANE 5 152 4.05e-06 0.0005914
4 SYNAPSE PART 8 610 3.937e-06 0.0005914
5 EXTRACELLULAR SPACE 11 1376 5.262e-06 0.0006146
6 NEURON PART 10 1265 1.767e-05 0.001543
7 SYNAPSE 8 754 1.85e-05 0.001543
8 ENDOCYTIC VESICLE 5 256 5.016e-05 0.003661
9 PRESYNAPSE 5 283 8.062e-05 0.005232
10 WNT SIGNALOSOME 2 11 0.0001352 0.007895
11 CELL SURFACE 7 757 0.0001592 0.008451

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 32 151 3.694e-70 6.538e-68
2 hsa04916_Melanogenesis 16 101 2.895e-29 2.562e-27
3 hsa04340_Hedgehog_signaling_pathway 8 56 2.239e-14 1.321e-12
4 hsa04720_Long.term_potentiation 6 70 1.245e-09 5.511e-08
5 hsa04971_Gastric_acid_secretion 6 74 1.752e-09 6.202e-08
6 hsa04912_GnRH_signaling_pathway 6 101 1.163e-08 3.43e-07
7 hsa04012_ErbB_signaling_pathway 5 87 2.545e-07 6.436e-06
8 hsa04020_Calcium_signaling_pathway 6 177 3.304e-07 7.31e-06
9 hsa04510_Focal_adhesion 6 200 6.769e-07 1.331e-05
10 hsa04730_Long.term_depression 4 70 4.595e-06 8.132e-05
11 hsa04370_VEGF_signaling_pathway 4 76 6.386e-06 0.0001028
12 hsa04070_Phosphatidylinositol_signaling_system 4 78 7.084e-06 0.0001045
13 hsa04970_Salivary_secretion 4 89 1.198e-05 0.0001583
14 hsa04540_Gap_junction 4 90 1.252e-05 0.0001583
15 hsa04972_Pancreatic_secretion 4 101 1.976e-05 0.0002332
16 hsa04270_Vascular_smooth_muscle_contraction 4 116 3.408e-05 0.000377
17 hsa04010_MAPK_signaling_pathway 5 268 6.233e-05 0.0006239
18 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 136 6.345e-05 0.0006239
19 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.0002709 0.002524
20 hsa04722_Neurotrophin_signaling_pathway 3 127 0.001084 0.009346
21 hsa04380_Osteoclast_differentiation 3 128 0.001109 0.009346
22 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.002052 0.01651
23 hsa00562_Inositol_phosphate_metabolism 2 57 0.003747 0.02883
24 hsa04115_p53_signaling_pathway 2 69 0.005442 0.04014
25 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.006399 0.04531
26 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.01009 0.06871
27 hsa04114_Oocyte_meiosis 2 114 0.01429 0.09367
28 hsa04670_Leukocyte_transendothelial_migration 2 117 0.01501 0.09488
29 hsa04110_Cell_cycle 2 128 0.01778 0.108
30 hsa04360_Axon_guidance 2 130 0.01831 0.108
31 hsa04530_Tight_junction 2 133 0.01911 0.1091
32 hsa04630_Jak.STAT_signaling_pathway 2 155 0.02543 0.1406
33 hsa04062_Chemokine_signaling_pathway 2 189 0.0366 0.1963
34 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.04581 0.2385
35 hsa04740_Olfactory_transduction 2 388 0.1274 0.5766

Quest ID: e1976e9fc9cc79520e69b80227c1c646