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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7e-5p SCD -0.12 0.01166 1.67 0 miRNAWalker2 validate; MirTarget; miRNATAP -1.45 0.03369
2 hsa-miR-375 CLDN1 -0.4 7.0E-5 2.79 0 miRNAWalker2 validate -1.68 5.0E-5 25001509; 25001509; 25001509 CLDN1 messenger RNA and protein expression were attenuated by overexpression of miR-375 and increased by knockdown of miR-375 in NSCLC cell lines;In clinical NSCLC samples there was a negative correlation between miR-375 and CLDN1 expression r=-0.35 P=0.005;CLDN1 is a novel target of miR-375 and high miR-375 expression shortens survival in NSCLC
3 hsa-let-7d-5p SCD -0.04 0.13987 1.67 0 MirTarget; miRNATAP -4 0.03981
4 hsa-let-7d-5p CLDN1 -0.04 0.13987 2.79 0 MirTarget -6.37 0.03031
5 hsa-miR-1207-5p STMN2 0.07 0.07721 -1.59 0 MirTarget; PITA; miRNATAP -1.83 0.01357
6 hsa-miR-1207-5p GUCA2A 0.07 0.07721 -3.71 0 MirTarget -3.53 0.02669
7 hsa-miR-1207-5p LIFR 0.07 0.07721 -1.68 0 MirTarget -2.61 0.00306
8 hsa-miR-1207-5p DES 0.07 0.07721 -1.59 0 MirTarget -1.97 0.02365
9 hsa-miR-1246 FGL2 0.55 1.0E-5 -1.79 0 MirTarget -1.07 2.0E-5
10 hsa-miR-1254 LYPD8 0.19 0.03335 -2.69 0 MirTarget -1.23 0.00883
11 hsa-miR-1254 HHLA2 0.19 0.03335 -2.64 0 MirTarget -1.24 0.00939
12 hsa-miR-125a-5p FGB -0.15 3.0E-5 2.14 0.00022 MirTarget -4.72 0.02298
13 hsa-miR-1265 EDIL3 0.09 0.20918 -1.94 0 MirTarget -0.88 0.03828
14 hsa-miR-1275 HHLA2 0.24 0.00451 -2.64 0 MirTarget -1.13 0.02894
15 hsa-miR-1275 BMP3 0.24 0.00451 -2.02 0 MirTarget -0.78 0.02524
16 hsa-miR-1290 ADH1C 0.8 1.0E-5 -2.52 0 MirTarget -0.73 0.00607
17 hsa-miR-1290 DPT 0.8 1.0E-5 -1.85 0 MirTarget; PITA -0.5 0.00053
18 hsa-miR-1321 CA12 0.06 0.35164 -1.6 0 MirTarget -1.05 0.02188
19 hsa-miR-1323 FGB 0.04 0.64637 2.14 0.00022 MirTarget -1.56 0.03179
20 hsa-miR-1324 SCD -0.14 0.07825 1.67 0 MirTarget; mirMAP -0.76 0.04155
21 hsa-miR-140-3p CEMIP -0.23 0 2.31 0 MirTarget -5.21 0
22 hsa-miR-140-5p SCD -0.22 0.08168 1.67 0 MirTarget; PITA -0.59 0.01207
23 hsa-miR-140-5p CEMIP -0.22 0.08168 2.31 0 MirTarget; miRNATAP -0.81 0.0063
24 hsa-miR-188-5p LPAR1 0.48 7.0E-5 -1.8 0 MirTarget -0.72 0.00061
25 hsa-miR-199b-3p SCD -0.11 0.09641 1.67 0 MirTarget; PITA; miRNATAP -0.93 0.03877
26 hsa-miR-28-5p FGB -0.2 0.00202 2.14 0.00022 MirTarget -2.21 0.04018
27 hsa-miR-297 P2RY14 0.46 0.00212 -2.03 0 MirTarget -0.65 0.00069
28 hsa-miR-421 SLC4A4 0.37 0.00522 -3.55 0 MirTarget; PITA; miRanda; miRNATAP -1.07 0.00589
29 hsa-miR-421 ANO5 0.37 0.00522 -1.63 0 MirTarget; miRanda -0.42 0.03602
30 hsa-miR-485-5p CEMIP -0.03 0.76714 2.31 0 MirTarget -0.86 0.02703
31 hsa-miR-490-5p CEMIP -0.41 0.00013 2.31 0 MirTarget -1.02 0.00217
32 hsa-miR-512-3p ABCG2 0.13 0.10018 -2.3 0 MirTarget -1 0.03837
33 hsa-miR-519b-3p CEMIP -0.06 0.46149 2.31 0 MirTarget -1.09 0.03613
34 hsa-miR-548p STMN2 0.2 0.015 -1.59 0 MirTarget -0.65 0.03562
35 hsa-miR-548p MT1G 0.2 0.015 -2.56 0 MirTarget -1.16 0.04908
36 hsa-miR-595 MEP1A 0.4 0.00262 -2.34 0 MirTarget -0.79 0.03483
37 hsa-miR-599 BTNL3 0.07 0.27064 -1.68 0 MirTarget; miRanda -1.04 0.04833
38 hsa-miR-636 PRKACB 0.37 0.00023 -1.62 0 MirTarget; PITA -0.77 0.00798
39 hsa-miR-665 STMN2 0.29 0.01654 -1.59 0 MirTarget -0.52 0.00947
40 hsa-miR-665 SLC51B 0.29 0.01654 -2.18 0 MirTarget -0.81 0.004
41 hsa-miR-671-5p LRRC19 0.08 0.19316 -2.29 0 MirTarget -1.46 0.0364
42 hsa-miR-671-5p NXPE4 0.08 0.19316 -2.92 0 MirTarget -2.15 0.04837
43 hsa-miR-760 NXPE4 0.3 0.00381 -2.92 0 MirTarget -1.32 0.02113
44 hsa-miR-1294 CA7 0.17 0.0495 -1.8 0 PITA; miRNATAP -0.75 0.01932
45 hsa-miR-596 CA7 0.25 0.00696 -1.8 0 PITA -0.65 0.02138
46 hsa-miR-1246 PRKACB 0.55 1.0E-5 -1.62 0 PITA; mirMAP -0.98 1.0E-5
47 hsa-miR-1265 SFRP2 0.09 0.20918 -1.81 0 PITA -1.2 0.02966
48 hsa-miR-297 SPON1 0.46 0.00212 -1.75 0 PITA -0.74 0.00028
49 hsa-miR-596 CHRDL1 0.25 0.00696 -1.91 0 PITA; miRNATAP -0.61 0.03912
50 hsa-miR-28-5p UCA1 -0.2 0.00202 1.98 1.0E-5 miRanda -2.46 0.00246
51 hsa-miR-129-5p CXCL14 0.13 0.23985 -1.59 2.0E-5 miRanda; mirMAP -0.91 0.03322
52 hsa-miR-129-5p CEACAM7 0.13 0.23985 -3.39 0 miRanda -1.73 0.00945
53 hsa-miR-129-5p SLC26A2 0.13 0.23985 -3.06 0 miRanda -1.13 0.02273
54 hsa-miR-129-5p EDIL3 0.13 0.23985 -1.94 0 miRanda -0.6 0.04083
55 hsa-miR-129-5p UGT2B17 0.13 0.23985 -2.66 0 miRanda -1.03 0.04079
56 hsa-miR-361-5p UBD -0.01 0.80799 1.75 2.0E-5 miRanda -5.24 0.03293
57 hsa-miR-375 UBD -0.4 7.0E-5 1.75 2.0E-5 miRanda -1.42 0.0021
58 hsa-miR-342-3p SPP1 -0.2 3.0E-5 2.57 0 miRanda -2.81 0.02147
59 hsa-miR-342-3p CLDN1 -0.2 3.0E-5 2.79 0 miRanda -2.6 0.00578
60 hsa-miR-346 HHLA2 0.19 0.06051 -2.64 0 miRanda -0.88 0.03793
61 hsa-miR-422a FGB -0.45 0 2.14 0.00022 miRanda -1.88 0.01091
62 hsa-miR-429 OGN 0.31 0.04028 -2.63 0 miRanda -0.61 0.01661
63 hsa-miR-429 SLC26A3 0.31 0.04028 -4.1 0 miRanda -1.06 0.03021
64 hsa-miR-449a KRT20 0.08 0.42517 -2.1 0 miRanda -1.09 0.01909
65 hsa-miR-491-5p DPT 0.14 0.13574 -1.85 0 miRanda -0.7 0.02288
66 hsa-miR-491-5p MYH11 0.14 0.13574 -2.08 0 miRanda -0.76 0.0368
67 hsa-miR-496 BTNL3 0 0.99881 -1.68 0 miRanda -0.89 0.03001
68 hsa-miR-455-5p MEP1A 0.29 0.04118 -2.34 0 miRanda -0.71 0.04012
69 hsa-miR-455-5p ANGPTL1 0.29 0.04118 -2.3 0 miRanda -0.5 0.03432
70 hsa-miR-455-5p ABI3BP 0.29 0.04118 -2.25 0 miRanda -0.58 0.0081
71 hsa-miR-455-5p KRT20 0.29 0.04118 -2.1 0 miRanda -1.28 4.0E-5
72 hsa-miR-455-5p PLCE1 0.29 0.04118 -1.65 0 miRanda -0.44 0.01692
73 hsa-miR-455-5p SFRP2 0.29 0.04118 -1.81 0 miRanda -0.88 0.00133
74 hsa-miR-455-5p ST6GALNAC1 0.29 0.04118 -1.69 0 miRanda -0.81 5.0E-5
75 hsa-miR-455-5p BTNL3 0.29 0.04118 -1.68 0 miRanda -0.72 0.0022
76 hsa-miR-455-5p UGT2B17 0.29 0.04118 -2.66 0 miRanda -1.2 0.00083
77 hsa-miR-590-5p ABI3BP 0.15 0.06472 -2.25 0 miRanda -0.78 0.04743
78 hsa-miR-590-5p CA1 0.15 0.06472 -1.78 0 miRanda -0.78 0.04014
79 hsa-miR-590-5p SCN7A 0.15 0.06472 -1.7 0 miRanda -0.63 0.04169
80 hsa-miR-590-5p HPGD 0.15 0.06472 -1.71 0 miRanda -0.84 0.03713
81 hsa-miR-599 FABP2 0.07 0.27064 -2.68 0 miRanda -1.76 0.01695
82 hsa-miR-615-3p CHRDL1 0.22 0.06743 -1.91 0 miRanda -0.49 0.03843
83 hsa-miR-421 SLC17A4 0.37 0.00522 -1.99 0 miRanda -0.54 0.01704
84 hsa-miR-421 LPAR1 0.37 0.00522 -1.8 0 miRanda -0.56 0.00459
85 hsa-miR-421 ABI3BP 0.37 0.00522 -2.25 0 miRanda -0.71 0.00216
86 hsa-miR-421 MEP1A 0.37 0.00522 -2.34 0 miRanda -0.85 0.02126
87 hsa-miR-421 MYH11 0.37 0.00522 -2.08 0 miRanda -0.91 0.00014
88 hsa-miR-421 CA7 0.37 0.00522 -1.8 0 miRanda -0.44 0.02533
89 hsa-miR-421 CHRDL1 0.37 0.00522 -1.91 0 miRanda -0.55 0.00674
90 hsa-miR-421 ANGPTL1 0.37 0.00522 -2.3 0 miRanda -0.62 0.01265
91 hsa-miR-421 SFRP2 0.37 0.00522 -1.81 0 miRanda -0.85 0.00398
92 hsa-miR-421 SMPDL3A 0.37 0.00522 -1.8 0 miRanda -0.47 0.02123
93 hsa-miR-421 SCIN 0.37 0.00522 -1.65 0 miRanda -0.44 0.03799
94 hsa-miR-421 DPT 0.37 0.00522 -1.85 0 miRanda -0.65 0.0014
95 hsa-miR-421 PIGR 0.37 0.00522 -2.61 0 miRanda -1.35 0.00578
96 hsa-miR-421 SYNPO2 0.37 0.00522 -2 0 miRanda -0.73 0.00102
97 hsa-miR-421 CA2 0.37 0.00522 -2.93 0 miRanda -1.19 0.00094
98 hsa-miR-421 PLN 0.37 0.00522 -1.88 0 miRanda -0.63 0.00625
99 hsa-miR-421 TRPM6 0.37 0.00522 -2.35 0 miRanda -0.66 0.01527
100 hsa-miR-542-3p STMN2 0.08 0.38393 -1.59 0 miRanda -0.68 0.01168
101 hsa-miR-876-5p BTNL3 0.03 0.62638 -1.68 0 miRanda -1.41 0.01853
102 hsa-miR-543 AGR3 0 0.9695 -1.74 0 miRanda -0.78 0.03406
103 hsa-miR-1290 BCAS1 0.8 1.0E-5 -1.71 0 mirMAP -0.66 3.0E-5
104 hsa-miR-409-3p CA12 -0.01 0.91657 -1.6 0 mirMAP -0.61 0.04369
105 hsa-miR-498 CA12 0.1 0.28568 -1.6 0 mirMAP -0.66 0.03128
106 hsa-miR-631 CA12 0.25 0.0044 -1.6 0 mirMAP -1.02 0.00195
107 hsa-miR-665 CA12 0.29 0.01654 -1.6 0 mirMAP -0.73 0.00203
108 hsa-miR-875-3p CA12 0.18 0.096 -1.6 0 mirMAP -0.81 0.00208
109 hsa-miR-1290 SLC4A4 0.8 1.0E-5 -3.55 0 mirMAP -1.12 3.0E-5
110 hsa-miR-1290 PCSK5 0.8 1.0E-5 -1.59 0 mirMAP -0.4 0.00215
111 hsa-miR-320a SCD -0.07 0.01983 1.67 0 mirMAP -4.99 0.00013
112 hsa-miR-320b SCD -0.08 0.00621 1.67 0 mirMAP -5.94 1.0E-5
113 hsa-miR-320c SCD -0.07 0.01062 1.67 0 mirMAP -5.86 2.0E-5
114 hsa-miR-320d SCD -0.1 0.00072 1.67 0 mirMAP -5.69 0
115 hsa-miR-1246 LIFR 0.55 1.0E-5 -1.68 0 mirMAP -0.74 0.00065
116 hsa-miR-1246 TPH1 0.55 1.0E-5 -3.13 0 mirMAP -1.41 1.0E-5
117 hsa-miR-1290 SLC26A2 0.8 1.0E-5 -3.06 0 mirMAP -1.01 0.00015
118 hsa-miR-556-5p SLC26A2 0.21 0.0022 -3.06 0 mirMAP -1.95 0.00992
119 hsa-miR-875-3p AHCYL2 0.18 0.096 -1.65 0 mirMAP -0.76 0.00485
120 hsa-miR-548c-5p CLDN1 -0.17 0.04056 2.79 0 mirMAP -1.34 0.01387
121 hsa-miR-559 CLDN1 -0.09 0.26442 2.79 0 mirMAP -1.27 0.02287
122 hsa-miR-1246 ANO5 0.55 1.0E-5 -1.63 0 mirMAP -0.62 0.00234
123 hsa-miR-1290 ANO5 0.8 1.0E-5 -1.63 0 mirMAP -0.44 0.00168
124 hsa-miR-1246 ADH1B 0.55 1.0E-5 -1.65 0 mirMAP -0.59 0.01824
125 hsa-miR-375 CEMIP -0.4 7.0E-5 2.31 0 miRNATAP -1.21 0.00062
126 hsa-miR-1207-5p F13A1 0.07 0.07721 -1.91 0 miRNATAP -3.05 0.00141
127 hsa-miR-1207-5p SFRP2 0.07 0.07721 -1.81 0 miRNATAP -3.33 0.00609
128 hsa-miR-875-3p LRRC19 0.18 0.096 -2.29 0 miRNATAP -1.15 0.00121
129 hsa-miR-484 DES 0.16 0.10284 -1.59 0 miRNATAP -0.68 0.02326
130 hsa-miR-876-5p C10orf99 0.03 0.62638 -1.87 0 miRNATAP -1.97 0.0089
131 hsa-miR-548d-3p MMP7 -0.26 0.00045 3.2 0 miRNATAP -1.57 0.0378
132 hsa-miR-429 FGL2 0.31 0.04028 -1.79 0 miRNATAP -0.52 0.02289
133 hsa-miR-429 DPT 0.31 0.04028 -1.85 0 miRNATAP -0.48 0.00892
134 hsa-miR-595 SYNPO2 0.4 0.00262 -2 0 miRNATAP -0.49 0.03379
135 hsa-miR-595 SLC26A2 0.4 0.00262 -3.06 0 miRNATAP -0.94 0.01526
136 hsa-miR-1254 PADI2 0.19 0.03335 -1.96 0 miRNATAP -0.83 0.01321
137 hsa-miR-513a-5p LIFR 0.14 0.13621 -1.68 0 miRNATAP -0.8 0.01402
138 hsa-miR-513a-5p STMN2 0.14 0.13621 -1.59 0 miRNATAP -0.62 0.02245
139 hsa-miR-513a-5p BMP3 0.14 0.13621 -2.02 0 miRNATAP -0.69 0.03393
140 hsa-miR-1290 SPARCL1 0.8 1.0E-5 -2.26 0 miRNATAP -0.93 0
141 hsa-miR-1290 SYNPO2 0.8 1.0E-5 -2 0 miRNATAP -0.64 4.0E-5
142 hsa-miR-760 PADI2 0.3 0.00381 -1.96 0 miRNATAP -0.65 0.02465
143 hsa-miR-1827 SCD -0.25 0.006 1.67 0 miRNATAP -0.75 0.01921

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 BICARBONATE TRANSPORT 7 44 1.635e-10 7.607e-07
2 ONE CARBON METABOLIC PROCESS 5 37 1.815e-07 0.0004222
3 MONOVALENT INORGANIC CATION HOMEOSTASIS 6 123 4.55e-06 0.005547
4 ION HOMEOSTASIS 11 576 4.769e-06 0.005547
5 REGULATION OF CELLULAR PH 5 75 6.483e-06 0.006033
6 CHEMICAL HOMEOSTASIS 13 874 9.126e-06 0.007077
7 REGULATION OF PH 5 89 1.501e-05 0.009979
NumGOOverlapSizeP ValueAdj. P Value
1 CARBONATE DEHYDRATASE ACTIVITY 4 14 1.341e-07 0.0001246
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 20 1376 2.874e-08 1.678e-05

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa00910_Nitrogen_metabolism 4 387 0.0467 1
2 hsa04976_Bile_secretion 4 387 0.0467 1
3 hsa00830_Retinol_metabolism 3 387 0.1538 1
4 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 3 387 0.1538 1
5 hsa00982_Drug_metabolism_._cytochrome_P450 3 387 0.1538 1
6 hsa04020_Calcium_signaling_pathway 3 387 0.1538 1
7 hsa04310_Wnt_signaling_pathway 3 387 0.1538 1
8 hsa04972_Pancreatic_secretion 3 387 0.1538 1
9 hsa00010_Glycolysis_._Gluconeogenesis 2 387 0.3938 1
10 hsa00071_Fatty_acid_metabolism 2 387 0.3938 1
11 hsa00350_Tyrosine_metabolism 2 387 0.3938 1
12 hsa03320_PPAR_signaling_pathway 2 387 0.3938 1
13 hsa04062_Chemokine_signaling_pathway 2 387 0.3938 1
14 hsa04270_Vascular_smooth_muscle_contraction 2 387 0.3938 1
15 hsa04530_Tight_junction 2 387 0.3938 1
16 hsa04540_Gap_junction 2 387 0.3938 1
17 hsa04610_Complement_and_coagulation_cascades 2 387 0.3938 1
18 hsa04964_Proximal_tubule_bicarbonate_reclamation 2 387 0.3938 1
19 hsa04971_Gastric_acid_secretion 2 387 0.3938 1

Quest ID: e1fcb8370107eeb05216ea5de3bfd66f