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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-3p ABCA1 0.47 0 -1.41 0 mirMAP; miRNATAP -0.16 0.00012 NA
2 hsa-miR-181b-5p ABCA1 1.23 0 -1.41 0 miRNATAP -0.32 0 NA
3 hsa-miR-181b-5p ABCA5 1.23 0 -1.92 0 mirMAP -0.37 0 NA
4 hsa-miR-15a-5p ABCB5 0.81 0 -4.85 0 MirTarget -0.85 0 NA
5 hsa-miR-125a-5p ABCB8 -0.64 0 1.13 0 miRanda -0.19 0 NA
6 hsa-miR-125a-5p ABCB9 -0.64 0 0.95 0 mirMAP -0.15 0.00018 NA
7 hsa-miR-125a-5p ABCC4 -0.64 0 -0.06 0.70716 miRanda -0.17 0.00299 NA
8 hsa-let-7a-3p ABCC9 0.47 0 -2.42 0 mirMAP -0.35 0 NA
9 hsa-let-7a-3p ABCD2 0.47 0 -4.13 0 mirMAP -0.5 0 NA
10 hsa-miR-15a-5p ABHD13 0.81 0 -0.44 0 MirTarget; miRNATAP -0.13 0 NA
11 hsa-miR-181b-5p ABHD13 1.23 0 -0.44 0 MirTarget -0.12 0 NA
12 hsa-miR-181b-5p ABHD15 1.23 0 -0.6 0 mirMAP -0.21 0 NA
13 hsa-let-7a-3p ABI3BP 0.47 0 -2.67 0 miRNATAP -0.6 0 NA
14 hsa-miR-181b-5p ABI3BP 1.23 0 -2.67 0 miRNATAP -0.51 0 NA
15 hsa-miR-125a-5p ABTB1 -0.64 0 -0.46 0 MirTarget; PITA; miRanda; miRNATAP -0.11 0.00149 NA
16 hsa-miR-181b-5p ACAP2 1.23 0 -0.39 0 MirTarget; miRNATAP -0.16 0 NA
17 hsa-miR-181b-5p ACER3 1.23 0 -0.64 0 MirTarget -0.12 0.00017 NA
18 hsa-miR-125a-5p ACHE -0.64 0 -0.23 0.22278 MirTarget; miRanda -0.32 0 NA
19 hsa-miR-15a-5p ACOX1 0.81 0 -0.61 0 miRNATAP -0.12 1.0E-5 NA
20 hsa-miR-181b-5p ACSL1 1.23 0 -2.41 0 MirTarget -0.42 0 NA
21 hsa-miR-15a-5p ACSL4 0.81 0 -1.48 0 MirTarget; miRNATAP -0.35 0 NA
22 hsa-miR-181b-5p ACSL4 1.23 0 -1.48 0 mirMAP -0.16 1.0E-5 NA
23 hsa-miR-15a-5p ACSS2 0.81 0 -1.5 0 MirTarget -0.11 0.0013 NA
24 hsa-miR-181b-5p ACSS3 1.23 0 -1.68 0 MirTarget -0.34 0 NA
25 hsa-miR-181b-5p ACVR1C 1.23 0 -5.2 0 miRNATAP -0.74 0 NA
26 hsa-miR-15a-5p ACVR2A 0.81 0 -0.96 0 MirTarget; miRNATAP -0.37 0 NA
27 hsa-miR-181b-5p ACVR2A 1.23 0 -0.96 0 MirTarget; miRNATAP -0.12 0 NA
28 hsa-miR-15a-5p ACVR2B 0.81 0 -0.11 0.19606 miRNATAP -0.18 0 NA
29 hsa-miR-125a-5p ADAM19 -0.64 0 1.6 0 mirMAP -0.29 0 NA
30 hsa-miR-181b-5p ADAM22 1.23 0 -1.22 0 mirMAP; miRNATAP -0.29 0 NA
31 hsa-let-7a-3p ADAM23 0.47 0 -0.63 0.00091 mirMAP -0.35 0 NA
32 hsa-miR-181b-5p ADAMTS1 1.23 0 -2.52 0 miRNATAP -0.26 0 NA
33 hsa-miR-125a-5p ADAMTS13 -0.64 0 0.49 0.00058 mirMAP -0.18 0.00045 NA
34 hsa-miR-125a-5p ADAMTS14 -0.64 0 3.73 0 miRanda; mirMAP -0.47 0 NA
35 hsa-miR-15a-5p ADAMTS18 0.81 0 -2.9 0 miRNATAP -0.6 0 NA
36 hsa-miR-181b-5p ADAMTS18 1.23 0 -2.9 0 miRNATAP -0.38 0 NA
37 hsa-miR-15a-5p ADAMTS3 0.81 0 -1.85 0 miRNATAP -0.4 0 NA
38 hsa-let-7a-3p ADAMTS5 0.47 0 -3.55 0 mirMAP -0.35 0 NA
39 hsa-miR-15a-5p ADAMTS5 0.81 0 -3.55 0 miRNATAP -0.79 0 NA
40 hsa-miR-181b-5p ADAMTS5 1.23 0 -3.55 0 mirMAP; miRNATAP -0.48 0 NA
41 hsa-miR-181b-5p ADAMTSL1 1.23 0 -1.1 0 miRNATAP -0.21 0 NA
42 hsa-let-7a-3p ADAMTSL3 0.47 0 -1.39 0 MirTarget -0.13 0.04911 NA
43 hsa-miR-15a-5p ADAMTSL3 0.81 0 -1.39 0 MirTarget -0.46 0 NA
44 hsa-miR-181b-5p ADARB2 1.23 0 -1.08 1.0E-5 MirTarget -0.21 0.00349 NA
45 hsa-miR-15a-5p ADCY1 0.81 0 -0.05 0.84149 mirMAP -0.27 0.00416 NA
46 hsa-miR-181b-5p ADCY1 1.23 0 -0.05 0.84149 miRNATAP -0.45 0 NA
47 hsa-miR-15a-5p ADCY5 0.81 0 -2.97 0 MirTarget; miRNATAP -0.65 0 NA
48 hsa-miR-181b-5p ADCY9 1.23 0 0.12 0.23839 miRNATAP -0.22 0 24269684 miR 181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 AC9 in cervical cancer cells; Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis
49 hsa-let-7a-3p ADCYAP1 0.47 0 -0.67 0.02162 miRNATAP -0.26 0.01703 NA
50 hsa-miR-125a-5p ADD2 -0.64 0 -1.02 0 MirTarget; miRanda -0.13 0.04792 NA
51 hsa-let-7a-3p ADD3 0.47 0 -1.66 0 mirMAP; miRNATAP -0.13 0.00891 NA
52 hsa-miR-125a-5p ADM2 -0.64 0 2.41 0 mirMAP -0.3 0 NA
53 hsa-miR-15a-5p ADRB2 0.81 0 -3.09 0 MirTarget -0.5 0 NA
54 hsa-miR-15a-5p AEBP2 0.81 0 -0.44 0 MirTarget -0.14 0 NA
55 hsa-miR-181b-5p AFF1 1.23 0 -0.82 0 mirMAP; miRNATAP -0.28 0 NA
56 hsa-let-7a-3p AFF2 0.47 0 -1.78 0 mirMAP -0.3 2.0E-5 NA
57 hsa-miR-15a-5p AFF4 0.81 0 -0.28 0.00153 MirTarget; miRNATAP -0.32 0 NA
58 hsa-miR-181b-5p AFF4 1.23 0 -0.28 0.00153 mirMAP; miRNATAP -0.23 0 NA
59 hsa-miR-181b-5p AGGF1 1.23 0 0.05 0.38271 mirMAP -0.1 0 NA
60 hsa-miR-15a-5p AGPAT4 0.81 0 -0.74 0 mirMAP -0.11 0.01325 NA
61 hsa-miR-125a-5p AGTRAP -0.64 0 0.92 0 miRNAWalker2 validate; miRanda -0.17 0 NA
62 hsa-miR-15a-5p AHCYL2 0.81 0 -0.11 0.19404 miRNATAP -0.19 0 NA
63 hsa-miR-15a-5p AKAP11 0.81 0 -0.85 0 MirTarget; miRNATAP -0.26 0 NA
64 hsa-let-7a-3p AKAP12 0.47 0 -2.76 0 miRNATAP -0.46 0 NA
65 hsa-miR-125a-5p AKNA -0.64 0 -0.23 0.01453 mirMAP -0.25 0 NA
66 hsa-miR-181b-5p AKR1C1 1.23 0 -4.35 0 mirMAP -0.28 0.00053 NA
67 hsa-miR-125a-5p AKR1E2 -0.64 0 -0.96 0 miRanda -0.19 0.00739 NA
68 hsa-miR-15a-5p AKT3 0.81 0 -1.39 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.51 0 NA
69 hsa-miR-181b-5p AKT3 1.23 0 -1.39 0 miRNATAP -0.23 0 NA
70 hsa-miR-15a-5p ALX4 0.81 0 -3.22 0 mirMAP -0.84 0 NA
71 hsa-miR-125a-5p AMDHD2 -0.64 0 0.93 0 miRanda -0.3 0 NA
72 hsa-let-7a-3p AMIGO2 0.47 0 -1.58 0 MirTarget; mirMAP -0.15 0.03432 NA
73 hsa-miR-125a-5p AMIGO3 -0.64 0 1.09 0 mirMAP -0.27 0 NA
74 hsa-miR-15a-5p AMMECR1L 0.81 0 -0.14 0.00103 MirTarget -0.15 0 NA
75 hsa-let-7a-3p AMOTL1 0.47 0 -1.81 0 mirMAP -0.2 9.0E-5 NA
76 hsa-miR-15a-5p AMOTL1 0.81 0 -1.81 0 MirTarget; miRNATAP -0.53 0 NA
77 hsa-let-7a-3p AMOTL2 0.47 0 -1.57 0 miRNATAP -0.21 0 NA
78 hsa-miR-125a-5p AMPD2 -0.64 0 0.4 0 miRanda -0.12 0 NA
79 hsa-miR-15a-5p ANK2 0.81 0 -2.51 0 MirTarget; miRNATAP -0.47 0 NA
80 hsa-miR-181b-5p ANKFY1 1.23 0 -0.49 0 mirMAP -0.15 0 NA
81 hsa-miR-15a-5p ANKIB1 0.81 0 0.04 0.58001 miRNATAP -0.19 0 NA
82 hsa-miR-181b-5p ANKRD12 1.23 0 -0.64 0 mirMAP -0.26 0 NA
83 hsa-miR-181b-5p ANKRD13C 1.23 0 -0.16 0.00093 MirTarget -0.12 0 NA
84 hsa-miR-15a-5p ANKRD29 0.81 0 -2.95 0 MirTarget -0.53 0 NA
85 hsa-miR-15a-5p ANKRD46 0.81 0 -0.46 0 MirTarget -0.13 5.0E-5 NA
86 hsa-miR-15a-5p ANKS1A 0.81 0 -0.37 0 MirTarget -0.12 0 NA
87 hsa-miR-125a-5p ANKS6 -0.64 0 -0.81 0 MirTarget -0.19 0.00032 NA
88 hsa-let-7a-3p ANO1 0.47 0 -0.88 0 MirTarget; miRNATAP -0.18 0.00235 NA
89 hsa-miR-15a-5p ANO3 0.81 0 -3.65 0 MirTarget; miRNATAP -0.65 0 NA
90 hsa-miR-181b-5p ANTXR2 1.23 0 -1.7 0 mirMAP -0.24 0 NA
91 hsa-miR-125a-5p APC2 -0.64 0 0.94 0 mirMAP -0.15 0.0043 NA
92 hsa-miR-15a-5p APLNR 0.81 0 -0.65 0 MirTarget -0.12 0.00686 NA
93 hsa-miR-15a-5p APP 0.81 0 -0.38 1.0E-5 miRNAWalker2 validate; miRNATAP -0.18 0 NA
94 hsa-miR-15a-5p AR 0.81 0 -1 0.00094 mirMAP; miRNATAP -0.95 0 NA
95 hsa-miR-181b-5p AR 1.23 0 -1 0.00094 miRNATAP -0.79 0 NA
96 hsa-miR-125a-5p ARF5 -0.64 0 0.83 0 miRanda -0.16 0 NA
97 hsa-miR-181b-5p ARFGEF2 1.23 0 -0 0.96671 MirTarget; miRNATAP -0.18 0 NA
98 hsa-miR-181b-5p ARFIP1 1.23 0 0.02 0.72019 mirMAP -0.11 0 NA
99 hsa-miR-125a-5p ARFRP1 -0.64 0 0.65 0 mirMAP -0.24 0 NA
100 hsa-miR-15a-5p ARHGAP12 0.81 0 -0.58 0 miRNATAP -0.3 0 NA
101 hsa-miR-181b-5p ARHGAP12 1.23 0 -0.58 0 mirMAP -0.18 0 NA
102 hsa-miR-15a-5p ARHGAP19 0.81 0 -0.97 0 MirTarget; mirMAP -0.22 0 NA
103 hsa-miR-181b-5p ARHGAP19 1.23 0 -0.97 0 mirMAP -0.14 0 NA
104 hsa-let-7a-3p ARHGAP20 0.47 0 -3.51 0 MirTarget; miRNATAP -0.48 0 NA
105 hsa-miR-15a-5p ARHGAP20 0.81 0 -3.51 0 MirTarget; miRNATAP -0.87 0 NA
106 hsa-miR-125a-5p ARHGAP25 -0.64 0 -0.63 0 miRanda -0.22 0 NA
107 hsa-miR-125a-5p ARHGAP27 -0.64 0 0.09 0.24597 miRanda -0.18 0 NA
108 hsa-let-7a-3p ARHGAP28 0.47 0 -1.18 0 mirMAP -0.2 0.00079 NA
109 hsa-let-7a-3p ARHGAP29 0.47 0 -1.05 0 mirMAP -0.15 0.00132 NA
110 hsa-miR-15a-5p ARHGAP32 0.81 0 0.43 9.0E-5 MirTarget -0.29 0 NA
111 hsa-miR-181b-5p ARHGAP32 1.23 0 0.43 9.0E-5 mirMAP -0.1 0.00146 NA
112 hsa-miR-15a-5p ARHGAP5 0.81 0 -0.91 0 MirTarget; miRNATAP -0.38 0 NA
113 hsa-miR-181b-5p ARHGAP5 1.23 0 -0.91 0 mirMAP -0.27 0 NA
114 hsa-miR-125a-5p ARHGEF1 -0.64 0 0.58 0 PITA; miRanda; miRNATAP -0.26 0 NA
115 hsa-miR-15a-5p ARHGEF12 0.81 0 -0.51 0 MirTarget -0.38 0 NA
116 hsa-miR-181b-5p ARHGEF3 1.23 0 -0.04 0.65559 MirTarget -0.13 0 NA
117 hsa-miR-181b-5p ARID2 1.23 0 0.01 0.8705 mirMAP -0.14 0 NA
118 hsa-miR-125a-5p ARID3A -0.64 0 0.82 0 miRNATAP -0.17 0 NA
119 hsa-let-7a-3p ARID5B 0.47 0 -1.75 0 miRNATAP -0.26 0 NA
120 hsa-miR-15a-5p ARIH1 0.81 0 -0.29 0 MirTarget -0.23 0 NA
121 hsa-miR-181b-5p ARIH1 1.23 0 -0.29 0 MirTarget; mirMAP -0.14 0 NA
122 hsa-let-7a-3p ARL10 0.47 0 -1.27 0 mirMAP -0.13 0.01783 NA
123 hsa-miR-181b-5p ARL5B 1.23 0 -0.21 0.05802 mirMAP -0.11 0.00096 NA
124 hsa-miR-15a-5p ARMC8 0.81 0 -0.25 0 MirTarget; miRNATAP -0.1 0 NA
125 hsa-miR-181b-5p ARNT2 1.23 0 1.54 0 miRNATAP -0.13 0.01707 NA
126 hsa-let-7a-3p ARRDC3 0.47 0 -1.47 0 MirTarget -0.12 0.00354 NA
127 hsa-miR-181b-5p ARRDC3 1.23 0 -1.47 0 MirTarget; mirMAP; miRNATAP -0.23 0 NA
128 hsa-miR-181b-5p ARRDC4 1.23 0 -1.24 0 miRNATAP -0.26 0 NA
129 hsa-miR-125a-5p ARSI -0.64 0 1.53 0 MirTarget; miRanda -0.35 0 NA
130 hsa-let-7a-3p ART4 0.47 0 -3.25 0 mirMAP -0.54 0 NA
131 hsa-let-7a-3p ARX 0.47 0 0.32 0.32475 miRNATAP -0.31 0.01132 NA
132 hsa-miR-15a-5p ASB1 0.81 0 -0.93 0 MirTarget; miRNATAP -0.1 5.0E-5 NA
133 hsa-miR-125a-5p ASB2 -0.64 0 -0.56 0.00057 miRanda -0.55 0 NA
134 hsa-miR-15a-5p ASH1L 0.81 0 -0.4 1.0E-5 MirTarget; miRNATAP -0.29 0 NA
135 hsa-miR-15a-5p ASNSD1 0.81 0 -0.26 0 miRNAWalker2 validate -0.11 0 NA
136 hsa-miR-181b-5p ASPA 1.23 0 -3.96 0 mirMAP -0.65 0 NA
137 hsa-miR-15a-5p ASPH 0.81 0 -1.12 0 miRNATAP -0.29 0 NA
138 hsa-miR-181b-5p ASPH 1.23 0 -1.12 0 mirMAP -0.27 0 NA
139 hsa-miR-15a-5p ASTN1 0.81 0 -2.96 0 MirTarget -0.73 0 NA
140 hsa-miR-181b-5p ASTN1 1.23 0 -2.96 0 MirTarget -0.38 0 NA
141 hsa-miR-15a-5p ASXL2 0.81 0 -0.86 0 miRNAWalker2 validate -0.58 0 NA
142 hsa-miR-181b-5p ASXL2 1.23 0 -0.86 0 mirMAP -0.36 0 NA
143 hsa-miR-181b-5p ATE1 1.23 0 -0.72 0 mirMAP -0.29 0 NA
144 hsa-miR-15a-5p ATF2 0.81 0 -0.53 0 miRNAWalker2 validate -0.36 0 NA
145 hsa-miR-181b-5p ATF2 1.23 0 -0.53 0 mirMAP; miRNATAP -0.24 0 NA
146 hsa-miR-15a-5p ATF6 0.81 0 0.17 0.01386 MirTarget -0.16 0 NA
147 hsa-miR-125a-5p ATG16L2 -0.64 0 0.4 0.00053 miRanda -0.14 0.00097 NA
148 hsa-miR-181b-5p ATG2B 1.23 0 -0.69 0 mirMAP -0.23 0 NA
149 hsa-miR-125a-5p ATG4D -0.64 0 1.02 0 PITA; miRanda; miRNATAP -0.19 0 NA
150 hsa-miR-181b-5p ATL3 1.23 0 -0.22 0.01349 mirMAP -0.12 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 282 1672 4.438e-23 2.065e-19
2 PROTEIN PHOSPHORYLATION 186 944 1.086e-22 2.527e-19
3 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 192 1021 5.581e-21 8.656e-18
4 REGULATION OF CELL DIFFERENTIATION 252 1492 1.125e-20 1.105e-17
5 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 288 1784 1.187e-20 1.105e-17
6 CARDIOVASCULAR SYSTEM DEVELOPMENT 158 788 3.888e-20 2.585e-17
7 CIRCULATORY SYSTEM DEVELOPMENT 158 788 3.888e-20 2.585e-17
8 NEUROGENESIS 238 1402 8.192e-20 4.765e-17
9 PHOSPHORYLATION 215 1228 1.593e-19 8.233e-17
10 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 203 1142 3.222e-19 1.499e-16
11 POSITIVE REGULATION OF CELL COMMUNICATION 251 1532 8.134e-19 3.441e-16
12 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 302 1977 4.76e-18 1.846e-15
13 POSITIVE REGULATION OF RESPONSE TO STIMULUS 295 1929 1.08e-17 3.867e-15
14 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 261 1656 2.574e-17 8.556e-15
15 INTRACELLULAR SIGNAL TRANSDUCTION 250 1572 4.428e-17 1.373e-14
16 POSITIVE REGULATION OF MOLECULAR FUNCTION 275 1791 1.025e-16 2.98e-14
17 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 227 1395 1.092e-16 2.989e-14
18 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 178 1008 1.237e-16 3.199e-14
19 RESPONSE TO ENDOGENOUS STIMULUS 233 1450 1.816e-16 4.448e-14
20 VASCULATURE DEVELOPMENT 103 469 3.253e-16 7.568e-14
21 REGULATION OF PROTEIN MODIFICATION PROCESS 261 1710 1.511e-15 3.348e-13
22 POSITIVE REGULATION OF GENE EXPRESSION 263 1733 2.348e-15 4.965e-13
23 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 269 1805 1.019e-14 1.896e-12
24 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 216 1360 9.497e-15 1.896e-12
25 TISSUE DEVELOPMENT 235 1518 1.01e-14 1.896e-12
26 REGULATION OF CELL DEATH 229 1472 1.357e-14 2.428e-12
27 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 138 750 1.588e-14 2.737e-12
28 POSITIVE REGULATION OF CELL DIFFERENTIATION 147 823 2.631e-14 4.373e-12
29 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 230 1492 3.234e-14 5.19e-12
30 REGULATION OF CELL MORPHOGENESIS 110 552 3.828e-14 5.938e-12
31 REGULATION OF CELL DEVELOPMENT 148 836 4.509e-14 6.768e-12
32 REGULATION OF TRANSPORT 266 1804 5.334e-14 7.756e-12
33 REGULATION OF CELL PROLIFERATION 229 1496 7.97e-14 1.124e-11
34 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 270 1848 9.991e-14 1.367e-11
35 RESPONSE TO GROWTH FACTOR 98 475 1.086e-13 1.443e-11
36 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 127 689 1.637e-13 2.116e-11
37 HEAD DEVELOPMENT 129 709 2.783e-13 3.5e-11
38 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 183 1135 3.315e-13 4.018e-11
39 REGULATION OF PHOSPHORUS METABOLIC PROCESS 241 1618 3.368e-13 4.018e-11
40 POSITIVE REGULATION OF CATALYTIC ACTIVITY 229 1518 3.792e-13 4.411e-11
41 NEGATIVE REGULATION OF CELL COMMUNICATION 189 1192 6.313e-13 7.164e-11
42 REGULATION OF NEURON DIFFERENTIATION 107 554 7.013e-13 7.416e-11
43 ORGAN MORPHOGENESIS 145 841 6.973e-13 7.416e-11
44 CENTRAL NERVOUS SYSTEM DEVELOPMENT 149 872 6.81e-13 7.416e-11
45 BIOLOGICAL ADHESION 169 1032 7.608e-13 7.867e-11
46 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 198 1275 1.237e-12 1.251e-10
47 HEART DEVELOPMENT 94 466 1.381e-12 1.367e-10
48 POSITIVE REGULATION OF CELL PROLIFERATION 140 814 2.147e-12 2.082e-10
49 NEGATIVE REGULATION OF GENE EXPRESSION 222 1493 3.932e-12 3.734e-10
50 REGULATION OF CELL PROJECTION ORGANIZATION 105 558 6.115e-12 5.691e-10
51 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 57 229 7.852e-12 7.133e-10
52 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 162 1004 7.972e-12 7.133e-10
53 REGULATION OF CELLULAR COMPONENT MOVEMENT 132 771 1.311e-11 1.151e-09
54 BLOOD VESSEL MORPHOGENESIS 77 364 1.356e-11 1.168e-09
55 REGULATION OF NEURON PROJECTION DEVELOPMENT 83 408 1.827e-11 1.546e-09
56 NEURON DIFFERENTIATION 144 874 2.707e-11 2.249e-09
57 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 144 876 3.206e-11 2.617e-09
58 REGULATION OF DEVELOPMENTAL GROWTH 65 289 3.416e-11 2.741e-09
59 REGULATION OF CELLULAR COMPONENT BIOGENESIS 130 767 3.811e-11 3.006e-09
60 CELL DEVELOPMENT 210 1426 3.991e-11 3.095e-09
61 REGULATION OF MAPK CASCADE 116 660 4.518e-11 3.446e-09
62 SKELETAL SYSTEM DEVELOPMENT 88 455 7.442e-11 5.585e-09
63 POSITIVE REGULATION OF LOCOMOTION 83 420 8.486e-11 6.268e-09
64 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 219 1517 9.515e-11 6.917e-09
65 POSITIVE REGULATION OF CELL DEVELOPMENT 90 472 9.884e-11 7.076e-09
66 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 125 740 1.153e-10 8.127e-09
67 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 161 1036 1.787e-10 1.223e-08
68 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 161 1036 1.787e-10 1.223e-08
69 LOCOMOTION 170 1114 2.267e-10 1.529e-08
70 REGULATION OF HYDROLASE ACTIVITY 195 1327 2.591e-10 1.722e-08
71 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 70 337 2.692e-10 1.764e-08
72 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 84 437 2.768e-10 1.789e-08
73 REGULATION OF CELL ADHESION 109 629 4.137e-10 2.637e-08
74 BEHAVIOR 94 516 4.806e-10 3.022e-08
75 SINGLE ORGANISM BEHAVIOR 76 384 4.938e-10 3.064e-08
76 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 173 1152 5.515e-10 3.377e-08
77 EMBRYO DEVELOPMENT 141 894 9.561e-10 5.778e-08
78 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 39 144 1.142e-09 6.812e-08
79 POSITIVE REGULATION OF NEURON DIFFERENTIATION 64 306 1.167e-09 6.872e-08
80 NEURON PROJECTION DEVELOPMENT 96 545 1.959e-09 1.139e-07
81 POSITIVE REGULATION OF MAPK CASCADE 86 470 2.125e-09 1.221e-07
82 NEGATIVE REGULATION OF CELL DEATH 137 872 2.16e-09 1.226e-07
83 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 77 404 2.286e-09 1.282e-07
84 RESPONSE TO HORMONE 139 893 3.041e-09 1.684e-07
85 ANGIOGENESIS 61 293 3.426e-09 1.875e-07
86 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 146 957 4.697e-09 2.541e-07
87 POSITIVE REGULATION OF HYDROLASE ACTIVITY 139 905 7.266e-09 3.886e-07
88 COGNITION 54 251 8.168e-09 4.319e-07
89 FOREBRAIN DEVELOPMENT 69 357 8.575e-09 4.483e-07
90 POSITIVE REGULATION OF GROWTH 52 238 8.862e-09 4.582e-07
91 CELL MOTILITY 130 835 9.945e-09 4.976e-07
92 REGULATION OF HOMEOSTATIC PROCESS 81 447 9.836e-09 4.976e-07
93 LOCALIZATION OF CELL 130 835 9.945e-09 4.976e-07
94 REGULATION OF GTPASE ACTIVITY 110 673 1.018e-08 5.039e-07
95 RESPONSE TO OXYGEN CONTAINING COMPOUND 194 1381 1.128e-08 5.525e-07
96 REGULATION OF TRANSFERASE ACTIVITY 143 946 1.244e-08 6.027e-07
97 POSITIVE REGULATION OF CELL DEATH 101 605 1.374e-08 6.589e-07
98 CELLULAR RESPONSE TO HORMONE STIMULUS 94 552 1.637e-08 7.77e-07
99 NEURON DEVELOPMENT 111 687 1.659e-08 7.796e-07
100 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 87 498 1.675e-08 7.796e-07
101 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 102 616 1.792e-08 8.254e-07
102 REGULATION OF EPITHELIAL CELL PROLIFERATION 58 285 1.961e-08 8.944e-07
103 REGULATION OF BMP SIGNALING PATHWAY 25 77 2.136e-08 9.649e-07
104 REGULATION OF EPITHELIAL CELL MIGRATION 40 166 2.666e-08 1.193e-06
105 CELL DEATH 148 1001 2.937e-08 1.301e-06
106 TUBE DEVELOPMENT 93 552 3.307e-08 1.452e-06
107 POSITIVE REGULATION OF TRANSPORT 140 936 3.463e-08 1.506e-06
108 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 46 207 3.649e-08 1.558e-06
109 EXTRACELLULAR STRUCTURE ORGANIZATION 60 304 3.622e-08 1.558e-06
110 REGULATION OF GROWTH 103 633 3.811e-08 1.612e-06
111 EMBRYONIC MORPHOGENESIS 91 539 4.203e-08 1.746e-06
112 RHYTHMIC PROCESS 59 298 4.182e-08 1.746e-06
113 MUSCLE STRUCTURE DEVELOPMENT 77 432 4.688e-08 1.93e-06
114 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 36 144 4.777e-08 1.95e-06
115 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 123 799 4.826e-08 1.953e-06
116 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 29 103 5.928e-08 2.378e-06
117 REGULATION OF IMMUNE SYSTEM PROCESS 193 1403 6.066e-08 2.412e-06
118 CELL PROLIFERATION 107 672 6.536e-08 2.577e-06
119 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 87 513 6.774e-08 2.606e-06
120 REGULATION OF ION TRANSPORT 97 592 6.773e-08 2.606e-06
121 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 100 616 6.777e-08 2.606e-06
122 POSITIVE REGULATION OF KINASE ACTIVITY 83 482 6.863e-08 2.618e-06
123 REGULATION OF OSSIFICATION 41 178 6.959e-08 2.632e-06
124 MEMORY 28 98 7.074e-08 2.654e-06
125 RESPONSE TO LIPID 133 888 7.129e-08 2.654e-06
126 REGULATION OF VASCULATURE DEVELOPMENT 49 233 8.388e-08 3.098e-06
127 RESPONSE TO OXYGEN LEVELS 60 311 8.464e-08 3.101e-06
128 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 156 1087 8.802e-08 3.2e-06
129 REGULATION OF CELL SUBSTRATE ADHESION 40 173 8.969e-08 3.235e-06
130 REGULATION OF KINASE ACTIVITY 119 776 9.915e-08 3.546e-06
131 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 122 801 9.984e-08 3.546e-06
132 MUSCLE ORGAN DEVELOPMENT 55 277 1.078e-07 3.798e-06
133 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 21 62 1.25e-07 4.373e-06
134 REGULATION OF CELLULAR LOCALIZATION 177 1277 1.339e-07 4.65e-06
135 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 37 156 1.352e-07 4.66e-06
136 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 34 138 1.63e-07 5.578e-06
137 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 58 303 1.827e-07 6.206e-06
138 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 48 232 1.903e-07 6.417e-06
139 REGULATION OF LIPID METABOLIC PROCESS 55 282 1.997e-07 6.683e-06
140 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 33 133 2.065e-07 6.865e-06
141 IMMUNE SYSTEM DEVELOPMENT 94 582 2.134e-07 7.041e-06
142 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 142 983 2.331e-07 7.637e-06
143 CELL ACTIVATION 92 568 2.52e-07 8.199e-06
144 REGULATION OF CHEMOTAXIS 40 180 2.773e-07 8.96e-06
145 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 54 278 2.944e-07 9.447e-06
146 NEGATIVE REGULATION OF CELL PROLIFERATION 101 643 2.976e-07 9.486e-06
147 CONNECTIVE TISSUE DEVELOPMENT 42 194 3.013e-07 9.538e-06
148 EPITHELIUM DEVELOPMENT 137 945 3.118e-07 9.803e-06
149 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 75 437 3.343e-07 1.044e-05
150 LEUKOCYTE ACTIVATION 72 414 3.405e-07 1.049e-05
151 REGULATION OF AXONOGENESIS 38 168 3.394e-07 1.049e-05
152 NEGATIVE REGULATION OF PHOSPHORYLATION 73 422 3.499e-07 1.071e-05
153 REGULATION OF OSTEOBLAST DIFFERENTIATION 29 112 4.239e-07 1.289e-05
154 CELL CELL ADHESION 96 608 4.602e-07 1.387e-05
155 TAXIS 78 464 4.62e-07 1.387e-05
156 REGULATION OF EXTENT OF CELL GROWTH 27 101 5.283e-07 1.575e-05
157 REGULATION OF BINDING 54 283 5.314e-07 1.575e-05
158 REGULATION OF CELL MATRIX ADHESION 25 90 6.3e-07 1.855e-05
159 REGULATION OF CELL ACTIVATION 80 484 6.657e-07 1.948e-05
160 REGULATION OF PROTEIN LOCALIZATION 136 950 7.043e-07 2.048e-05
161 TISSUE MORPHOGENESIS 86 533 7.291e-07 2.107e-05
162 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 30 121 7.395e-07 2.124e-05
163 RESPONSE TO ORGANIC CYCLIC COMPOUND 132 917 7.635e-07 2.179e-05
164 CELLULAR COMPONENT MORPHOGENESIS 130 900 7.697e-07 2.184e-05
165 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 78 470 7.787e-07 2.196e-05
166 SKELETAL SYSTEM MORPHOGENESIS 42 201 8.226e-07 2.306e-05
167 NEGATIVE REGULATION OF CELL DIFFERENTIATION 95 609 9.152e-07 2.55e-05
168 NEURON PROJECTION MORPHOGENESIS 69 402 9.741e-07 2.698e-05
169 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 46 232 1.201e-06 3.307e-05
170 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 15 39 1.237e-06 3.386e-05
171 PERICARDIUM DEVELOPMENT 10 18 1.27e-06 3.457e-05
172 HEART MORPHOGENESIS 43 212 1.414e-06 3.815e-05
173 NEURON PROJECTION GUIDANCE 42 205 1.418e-06 3.815e-05
174 FAT CELL DIFFERENTIATION 27 106 1.484e-06 3.969e-05
175 MULTI MULTICELLULAR ORGANISM PROCESS 43 213 1.611e-06 4.285e-05
176 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 18 55 1.743e-06 4.607e-05
177 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 25 95 1.887e-06 4.96e-05
178 REGULATION OF TRANSMEMBRANE TRANSPORT 71 426 2.059e-06 5.382e-05
179 DEVELOPMENTAL GROWTH 59 333 2.075e-06 5.393e-05
180 MEMBRANE DEPOLARIZATION 19 61 2.108e-06 5.444e-05
181 ANTERIOR POSTERIOR PATTERN SPECIFICATION 40 194 2.118e-06 5.444e-05
182 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 54 296 2.245e-06 5.739e-05
183 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 18 56 2.341e-06 5.95e-05
184 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 63 365 2.353e-06 5.95e-05
185 AMEBOIDAL TYPE CELL MIGRATION 34 154 2.468e-06 6.208e-05
186 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 85 541 2.546e-06 6.336e-05
187 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 85 541 2.546e-06 6.336e-05
188 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 107 724 2.598e-06 6.43e-05
189 REGULATION OF MEMBRANE POTENTIAL 60 343 2.613e-06 6.434e-05
190 REGULATION OF SECRETION 104 699 2.645e-06 6.477e-05
191 NEGATIVE REGULATION OF MOLECULAR FUNCTION 148 1079 2.736e-06 6.665e-05
192 PALATE DEVELOPMENT 23 85 2.871e-06 6.957e-05
193 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 39 190 3.168e-06 7.637e-05
194 NEURON MIGRATION 27 110 3.202e-06 7.681e-05
195 BONE DEVELOPMENT 34 156 3.347e-06 7.979e-05
196 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 26 104 3.361e-06 7.979e-05
197 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 86 554 3.639e-06 8.596e-05
198 INOSITOL LIPID MEDIATED SIGNALING 29 124 3.989e-06 9.375e-05
199 EMBRYONIC PATTERN SPECIFICATION 18 58 4.123e-06 9.64e-05
200 REGULATION OF METAL ION TRANSPORT 57 325 4.242e-06 9.868e-05
201 TELENCEPHALON DEVELOPMENT 44 228 4.273e-06 9.891e-05
202 REGULATION OF WNT SIGNALING PATHWAY 55 310 4.355e-06 0.0001003
203 TRANSMEMBRANE TRANSPORT 149 1098 4.602e-06 0.0001055
204 SYNAPSE ORGANIZATION 32 145 4.865e-06 0.000111
205 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 33 152 5.063e-06 0.0001149
206 WNT SIGNALING PATHWAY 60 351 5.554e-06 0.0001255
207 PALLIUM DEVELOPMENT 33 153 5.874e-06 0.000132
208 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 60 352 6.087e-06 0.0001362
209 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 62 368 6.3e-06 0.0001403
210 POSITIVE REGULATION OF BINDING 29 127 6.594e-06 0.0001461
211 UROGENITAL SYSTEM DEVELOPMENT 53 299 6.632e-06 0.0001463
212 CELLULAR RESPONSE TO NITROGEN COMPOUND 79 505 6.721e-06 0.0001468
213 POST EMBRYONIC DEVELOPMENT 23 89 6.693e-06 0.0001468
214 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 33 154 6.803e-06 0.0001479
215 IMMUNE SYSTEM PROCESS 245 1984 6.986e-06 0.0001512
216 CELLULAR RESPONSE TO LIPID 73 457 7.11e-06 0.000153
217 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 48 262 7.137e-06 0.000153
218 TUBE MORPHOGENESIS 56 323 7.322e-06 0.0001563
219 REGULATION OF RESPONSE TO STRESS 189 1468 7.367e-06 0.0001565
220 REGULATION OF SYSTEM PROCESS 79 507 7.794e-06 0.0001643
221 PATTERN SPECIFICATION PROCESS 68 418 7.806e-06 0.0001643
222 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 34 162 8.005e-06 0.0001678
223 RESPONSE TO EXTERNAL STIMULUS 227 1821 8.331e-06 0.0001738
224 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 128 926 8.981e-06 0.0001858
225 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 12 30 8.984e-06 0.0001858
226 SENSORY ORGAN DEVELOPMENT 77 493 9.283e-06 0.0001911
227 LYMPHOCYTE ACTIVATION 58 342 1.011e-05 0.0002072
228 PROTEIN POLYUBIQUITINATION 45 243 1.024e-05 0.0002088
229 PROTEIN AUTOPHOSPHORYLATION 38 192 1.028e-05 0.0002088
230 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 66 406 1.082e-05 0.0002188
231 POSITIVE REGULATION OF MAP KINASE ACTIVITY 40 207 1.107e-05 0.000223
232 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 51 289 1.115e-05 0.0002237
233 CARDIAC CHAMBER DEVELOPMENT 31 144 1.158e-05 0.0002312
234 REGULATION OF CELL SIZE 35 172 1.21e-05 0.0002406
235 LEARNING 29 131 1.248e-05 0.0002461
236 ORGAN GROWTH 19 68 1.243e-05 0.0002461
237 POSITIVE REGULATION OF CELL ADHESION 62 376 1.261e-05 0.0002476
238 MORPHOGENESIS OF AN EPITHELIUM 65 400 1.273e-05 0.0002489
239 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 73 465 1.314e-05 0.0002558
240 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 24 99 1.387e-05 0.0002677
241 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 24 99 1.387e-05 0.0002677
242 LEUKOCYTE DIFFERENTIATION 51 292 1.495e-05 0.0002874
243 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 32 153 1.573e-05 0.0003012
244 ARTERY DEVELOPMENT 20 75 1.588e-05 0.0003017
245 MORPHOGENESIS OF A BRANCHING STRUCTURE 34 167 1.583e-05 0.0003017
246 PEPTIDYL AMINO ACID MODIFICATION 117 841 1.631e-05 0.0003072
247 POSITIVE REGULATION OF CATABOLIC PROCESS 64 395 1.626e-05 0.0003072
248 REGULATION OF CELL CELL ADHESION 62 380 1.762e-05 0.0003306
249 CARTILAGE DEVELOPMENT 31 147 1.786e-05 0.0003338
250 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 34 168 1.806e-05 0.0003362
251 ACTIVATION OF PROTEIN KINASE ACTIVITY 49 279 1.874e-05 0.0003474
252 REGULATION OF RESPONSE TO WOUNDING 66 413 1.896e-05 0.0003487
253 RESPIRATORY SYSTEM DEVELOPMENT 38 197 1.893e-05 0.0003487
254 BLOOD VESSEL REMODELING 12 32 1.958e-05 0.0003572
255 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 19 70 1.957e-05 0.0003572
256 EYE DEVELOPMENT 55 326 1.973e-05 0.0003587
257 PEPTIDYL SERINE MODIFICATION 31 148 2.056e-05 0.0003723
258 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 37 191 2.197e-05 0.0003954
259 REGULATION OF ANATOMICAL STRUCTURE SIZE 73 472 2.202e-05 0.0003954
260 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 28 128 2.209e-05 0.0003954
261 REGULATION OF CELL GROWTH 63 391 2.249e-05 0.000399
262 SEGMENTATION 22 89 2.253e-05 0.000399
263 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 36 184 2.255e-05 0.000399
264 RESPONSE TO ABIOTIC STIMULUS 137 1024 2.283e-05 0.0004023
265 REGULATION OF LEUKOCYTE PROLIFERATION 39 206 2.312e-05 0.000406
266 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 24 102 2.365e-05 0.0004137
267 NEGATIVE REGULATION OF AXONOGENESIS 18 65 2.39e-05 0.0004165
268 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 43 236 2.402e-05 0.0004171
269 CATION TRANSPORT 111 796 2.422e-05 0.0004184
270 CELLULAR RESPONSE TO PEPTIDE 48 274 2.428e-05 0.0004184
271 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 14 43 2.614e-05 0.0004488
272 MUSCLE TISSUE DEVELOPMENT 48 275 2.675e-05 0.0004576
273 GROWTH 65 410 2.817e-05 0.0004801
274 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 21 84 2.86e-05 0.0004858
275 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 34 173 3.416e-05 0.000578
276 CARDIAC SEPTUM DEVELOPMENT 21 85 3.462e-05 0.0005837
277 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 13 39 3.818e-05 0.0006413
278 KIDNEY EPITHELIUM DEVELOPMENT 27 125 3.892e-05 0.0006514
279 REGULATION OF PEPTIDE TRANSPORT 45 256 3.942e-05 0.0006574
280 CAMP METABOLIC PROCESS 12 34 3.969e-05 0.0006596
281 RESPONSE TO STEROID HORMONE 75 497 3.985e-05 0.0006599
282 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 118 867 4.019e-05 0.0006632
283 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 97 684 4.074e-05 0.0006698
284 RESPONSE TO NITROGEN COMPOUND 117 859 4.19e-05 0.0006858
285 REGIONALIZATION 52 311 4.2e-05 0.0006858
286 CELLULAR RESPONSE TO ACID CHEMICAL 34 175 4.364e-05 0.00071
287 REGULATION OF ORGAN MORPHOGENESIS 43 242 4.461e-05 0.0007233
288 PROTEIN DEPHOSPHORYLATION 36 190 4.601e-05 0.0007408
289 STEM CELL DIFFERENTIATION 36 190 4.601e-05 0.0007408
290 REGULATION OF SYNAPTIC PLASTICITY 29 140 4.647e-05 0.0007456
291 ACTIN FILAMENT BASED PROCESS 69 450 4.825e-05 0.0007714
292 REGULATION OF TRANSPORTER ACTIVITY 37 198 4.949e-05 0.0007887
293 REGULATION OF FATTY ACID METABOLIC PROCESS 21 87 5.016e-05 0.0007928
294 REGULATION OF CATABOLIC PROCESS 102 731 5.009e-05 0.0007928
295 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 39 213 5.026e-05 0.0007928
296 SINGLE ORGANISM CELL ADHESION 70 459 5.08e-05 0.0007966
297 REGULATION OF CELLULAR COMPONENT SIZE 55 337 5.085e-05 0.0007966
298 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 13 40 5.166e-05 0.0008067
299 NEGATIVE REGULATION OF CHEMOTAXIS 15 51 5.228e-05 0.0008135
300 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 28 134 5.297e-05 0.0008188
301 MESENCHYMAL CELL DIFFERENTIATION 28 134 5.297e-05 0.0008188
302 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 118 873 5.428e-05 0.0008363
303 ACTION POTENTIAL 22 94 5.553e-05 0.0008527
304 REGULATION OF ENDOTHELIAL CELL MIGRATION 25 114 5.7e-05 0.0008722
305 NEGATIVE REGULATION OF OSSIFICATION 18 69 5.717e-05 0.0008722
306 REGULATION OF HOMOTYPIC CELL CELL ADHESION 51 307 5.887e-05 0.0008951
307 CELL PROJECTION ORGANIZATION 121 902 6.1e-05 0.0009246
308 RESPONSE TO PEPTIDE 63 404 6.126e-05 0.0009255
309 REGULATION OF ERK1 AND ERK2 CASCADE 42 238 6.399e-05 0.0009636
310 NEGATIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 28 136 6.978e-05 0.001044
311 CELLULAR RESPONSE TO OXYGEN LEVELS 29 143 6.96e-05 0.001044
312 METAL ION TRANSPORT 84 582 7.128e-05 0.00106
313 REGULATION OF PHOSPHOLIPASE ACTIVITY 17 64 7.125e-05 0.00106
314 REGULATION OF CALCIUM ION TRANSPORT 38 209 7.286e-05 0.00108
315 REGULATION OF ENERGY HOMEOSTASIS 8 17 7.326e-05 0.001082
316 CIRCULATORY SYSTEM PROCESS 58 366 7.514e-05 0.001106
317 NEGATIVE REGULATION OF LOCOMOTION 45 263 7.682e-05 0.001127
318 CYTOSKELETON DEPENDENT INTRACELLULAR TRANSPORT 25 116 7.703e-05 0.001127
319 MULTICELLULAR ORGANISMAL SIGNALING 26 123 7.88e-05 0.001146
320 MATERNAL PLACENTA DEVELOPMENT 11 31 7.866e-05 0.001146
321 REGULATION OF CIRCADIAN RHYTHM 23 103 8.284e-05 0.001199
322 REGULATION OF MAP KINASE ACTIVITY 52 319 8.301e-05 0.001199
323 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 15 53 8.537e-05 0.001226
324 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 15 53 8.537e-05 0.001226
325 LOCOMOTORY BEHAVIOR 34 181 8.815e-05 0.001262
326 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 25 117 8.924e-05 0.001274
327 PROTEIN UBIQUITINATION 89 629 9.059e-05 0.001289
328 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 49 297 9.694e-05 0.001375
329 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 36 197 0.0001001 0.001415
330 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 25 118 0.0001031 0.001454
331 ESTABLISHMENT OF LOCALIZATION IN CELL 204 1676 0.0001035 0.001454
332 ENDOTHELIAL CELL DIFFERENTIATION 18 72 0.0001043 0.001462
333 REGULATION OF NEUROTRANSMITTER LEVELS 35 190 0.0001052 0.001462
334 MESENCHYME DEVELOPMENT 35 190 0.0001052 0.001462
335 GLAND DEVELOPMENT 61 395 0.0001053 0.001462
336 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 17 66 0.0001082 0.001493
337 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 17 66 0.0001082 0.001493
338 CEREBRAL CORTEX DEVELOPMENT 23 105 0.0001131 0.001557
339 BONE MORPHOGENESIS 19 79 0.0001186 0.001628
340 APPENDAGE DEVELOPMENT 32 169 0.00012 0.001637
341 LIMB DEVELOPMENT 32 169 0.00012 0.001637
342 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 8 18 0.0001209 0.001645
343 ION TRANSPORT 159 1262 0.0001214 0.001647
344 REGULATION OF PROTEIN SECRETION 60 389 0.0001236 0.001672
345 REGULATION OF ORGAN GROWTH 18 73 0.0001263 0.001703
346 REGULATION OF CYTOPLASMIC TRANSPORT 71 481 0.0001268 0.001706
347 PROTEIN LOCALIZATION 217 1805 0.0001289 0.001729
348 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 7 14 0.0001312 0.001754
349 CYTOSKELETON ORGANIZATION 112 838 0.000132 0.00176
350 MODULATION OF SYNAPTIC TRANSMISSION 49 301 0.0001356 0.001802
351 POSITIVE REGULATION OF CHEMOTAXIS 25 120 0.0001369 0.00181
352 REGULATION OF DENDRITE DEVELOPMENT 25 120 0.0001369 0.00181
353 REGULATION OF DNA BINDING 21 93 0.0001403 0.00185
354 VESICLE MEDIATED TRANSPORT 156 1239 0.0001452 0.001909
355 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 22 100 0.0001477 0.001935
356 REGULATION OF DENDRITE MORPHOGENESIS 18 74 0.0001522 0.001989
357 PEPTIDYL TYROSINE MODIFICATION 34 186 0.000153 0.001994
358 REGULATION OF CELL CYCLE 124 949 0.0001551 0.002016
359 REGULATION OF FATTY ACID OXIDATION 10 28 0.0001563 0.002026
360 REGULATION OF LIPID BIOSYNTHETIC PROCESS 26 128 0.0001569 0.002028
361 REGULATION OF LEUKOCYTE DIFFERENTIATION 40 232 0.0001583 0.00204
362 RESPONSE TO ACID CHEMICAL 51 319 0.0001588 0.002041
363 PROTEIN CATABOLIC PROCESS 82 579 0.0001636 0.002098
364 SOMITOGENESIS 16 62 0.0001668 0.002133
365 OUTFLOW TRACT MORPHOGENESIS 15 56 0.0001689 0.002153
366 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 27 136 0.0001766 0.002245
367 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 25 122 0.0001801 0.00227
368 REGULATION OF AXON GUIDANCE 12 39 0.0001805 0.00227
369 TRABECULA MORPHOGENESIS 12 39 0.0001805 0.00227
370 NEGATIVE CHEMOTAXIS 12 39 0.0001805 0.00227
371 NEURAL CREST CELL DIFFERENTIATION 18 75 0.0001827 0.002291
372 REGULATION OF LONG TERM SYNAPTIC POTENTIATION 8 19 0.0001914 0.002394
373 GLYCEROLIPID BIOSYNTHETIC PROCESS 37 211 0.0001934 0.002412
374 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 31 166 0.0001971 0.002452
375 FOREBRAIN NEURON DEVELOPMENT 11 34 0.0002033 0.002498
376 CHEMICAL HOMEOSTASIS 115 874 0.0002025 0.002498
377 RESPONSE TO FLUID SHEAR STRESS 11 34 0.0002033 0.002498
378 POSITIVE REGULATION OF PROTEOLYSIS 56 363 0.0002034 0.002498
379 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 45 274 0.0002032 0.002498
380 CELL FATE COMMITMENT 39 227 0.0002048 0.002507
381 REGULATION OF JNK CASCADE 30 159 0.0002055 0.00251
382 CYCLIC NUCLEOTIDE METABOLIC PROCESS 15 57 0.0002093 0.002536
383 NEURAL CREST CELL MIGRATION 14 51 0.0002084 0.002536
384 APOPTOTIC MITOCHONDRIAL CHANGES 15 57 0.0002093 0.002536
385 REGULATION OF MYELOID CELL APOPTOTIC PROCESS 9 24 0.0002178 0.002633
386 REGULATION OF IMMUNE RESPONSE 113 858 0.0002213 0.002667
387 MYELOID LEUKOCYTE DIFFERENTIATION 21 96 0.000225 0.002694
388 REGULATION OF N METHYL D ASPARTATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 7 15 0.0002258 0.002694
389 ION HOMEOSTASIS 81 576 0.0002251 0.002694
390 EPITHELIAL CELL FATE COMMITMENT 7 15 0.0002258 0.002694
391 RESPONSE TO INSULIN 36 205 0.0002275 0.002708
392 REGULATION OF MUSCLE TISSUE DEVELOPMENT 22 103 0.0002318 0.002744
393 REGULATION OF MUSCLE ORGAN DEVELOPMENT 22 103 0.0002318 0.002744
394 REGULATION OF NEURON DEATH 42 252 0.0002358 0.002785
395 RESPONSE TO FATTY ACID 19 83 0.0002373 0.002795
396 DIVALENT INORGANIC CATION TRANSPORT 44 268 0.0002395 0.002814
397 REGULATION OF PROTEIN BINDING 31 168 0.000246 0.002884
398 ENDOTHELIUM DEVELOPMENT 20 90 0.0002517 0.002942
399 PROTEOLYSIS 151 1208 0.0002592 0.003023
400 REPRODUCTIVE SYSTEM DEVELOPMENT 61 408 0.0002599 0.003023
401 STEROID HORMONE MEDIATED SIGNALING PATHWAY 25 125 0.0002677 0.003106
402 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 23 111 0.0002707 0.003133
403 POSITIVE REGULATION OF OSSIFICATION 19 84 0.0002797 0.003229
404 LYMPH VESSEL DEVELOPMENT 8 20 0.0002925 0.003369
405 NEGATIVE REGULATION OF CELL MATRIX ADHESION 10 30 0.0002998 0.003436
406 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 10 30 0.0002998 0.003436
407 NEGATIVE REGULATION OF CELL DEVELOPMENT 48 303 0.0003028 0.003461
408 MYELOID LEUKOCYTE ACTIVATION 21 98 0.0003037 0.003464
409 AORTA DEVELOPMENT 12 41 0.0003047 0.003466
410 SOMITE DEVELOPMENT 18 78 0.0003083 0.003498
411 ODONTOGENESIS 22 105 0.000309 0.003498
412 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 9 25 0.0003118 0.003521
413 POSITIVE REGULATION OF CELL GROWTH 28 148 0.0003143 0.003541
414 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 34 193 0.0003151 0.003541
415 REGULATION OF ION HOMEOSTASIS 35 201 0.0003256 0.003651
416 AGING 43 264 0.0003336 0.003732
417 EPITHELIAL CELL DEVELOPMENT 33 186 0.0003354 0.003742
418 REGULATION OF ORGANELLE ORGANIZATION 147 1178 0.0003368 0.003749
419 NEGATIVE REGULATION OF NEURON DEATH 31 171 0.0003398 0.003774
420 CELLULAR MACROMOLECULE LOCALIZATION 153 1234 0.0003427 0.003797
421 REGULATION OF FAT CELL DIFFERENTIATION 22 106 0.0003554 0.003919
422 OVULATION CYCLE 23 113 0.0003553 0.003919
423 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 11 36 0.0003572 0.003929
424 REGULATION OF SYNAPSE ASSEMBLY 18 79 0.0003643 0.003997
425 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 7 16 0.0003685 0.004015
426 MAGNESIUM ION TRANSMEMBRANE TRANSPORT 7 16 0.0003685 0.004015
427 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 7 16 0.0003685 0.004015
428 REGULATION OF HEMOPOIESIS 49 314 0.0003765 0.004093
429 MATERNAL PROCESS INVOLVED IN FEMALE PREGNANCY 15 60 0.0003842 0.004167
430 POSITIVE REGULATION OF DNA BINDING 12 42 0.00039 0.004201
431 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 12 42 0.00039 0.004201
432 REGULATION OF INTRACELLULAR TRANSPORT 85 621 0.0003885 0.004201
433 GLYCEROLIPID METABOLIC PROCESS 54 356 0.0003995 0.004293
434 MACROPHAGE ACTIVATION 10 31 0.0004052 0.004339
435 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 21 100 0.0004057 0.004339
436 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 6 12 0.0004103 0.004378
437 RAS PROTEIN SIGNAL TRANSDUCTION 27 143 0.0004119 0.004386
438 EYE MORPHOGENESIS 26 136 0.0004278 0.004544
439 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 16 67 0.0004346 0.004607
440 POSITIVE REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 9 26 0.0004368 0.004609
441 HEART TRABECULA MORPHOGENESIS 9 26 0.0004368 0.004609
442 TISSUE REMODELING 19 87 0.0004489 0.004726
443 MYELOID CELL DIFFERENTIATION 33 189 0.0004516 0.004744
444 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 15 61 0.0004652 0.004876
445 ACTIVATION OF MAPK ACTIVITY 26 137 0.000481 0.00503
446 CEREBRAL CORTEX CELL MIGRATION 12 43 0.0004946 0.00516
447 EPITHELIAL CELL DIFFERENTIATION 70 495 0.0004972 0.005175
448 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 13 49 0.0005003 0.005196
449 REGULATION OF JUN KINASE ACTIVITY 18 81 0.0005031 0.005213
450 REGULATION OF CELL JUNCTION ASSEMBLY 16 68 0.0005189 0.005365
451 ESTABLISHMENT OF CELL POLARITY 19 88 0.0005223 0.005389
452 RESPONSE TO FIBROBLAST GROWTH FACTOR 23 116 0.0005255 0.005408
453 INORGANIC ION TRANSMEMBRANE TRANSPORT 80 583 0.0005265 0.005408
454 RESPONSE TO HYDROGEN PEROXIDE 22 109 0.0005334 0.005467
455 RESPONSE TO OXIDATIVE STRESS 53 352 0.0005376 0.005497
456 POSITIVE REGULATION OF CELL ACTIVATION 48 311 0.0005522 0.005634
457 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 17 75 0.0005596 0.005698
458 NEGATIVE REGULATION OF CELL AGING 7 17 0.0005751 0.005843
459 CELLULAR RESPONSE TO INSULIN STIMULUS 27 146 0.0005779 0.005859
460 NEGATIVE REGULATION OF CELL ADHESION 37 223 0.0005862 0.005919
461 CELLULAR RESPONSE TO OXIDATIVE STRESS 32 184 0.0005865 0.005919
462 LEUKOCYTE CELL CELL ADHESION 41 255 0.0005923 0.005965
463 COLLAGEN FIBRIL ORGANIZATION 11 38 0.0005988 0.005972
464 NEGATIVE REGULATION OF AXON EXTENSION 11 38 0.0005988 0.005972
465 HIPPO SIGNALING 9 27 0.0006004 0.005972
466 NEGATIVE REGULATION OF AXON GUIDANCE 9 27 0.0006004 0.005972
467 RESPONSE TO ALCOHOL 54 362 0.0006007 0.005972
468 POSITIVE REGULATION OF ORGAN GROWTH 11 38 0.0005988 0.005972
469 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 13 50 0.0006179 0.006117
470 REGULATION OF ADHERENS JUNCTION ORGANIZATION 13 50 0.0006179 0.006117
471 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 29 162 0.0006422 0.006344
472 RESPONSE TO DRUG 62 431 0.0006531 0.006438
473 NEGATIVE REGULATION OF CELL GROWTH 30 170 0.0006686 0.006577
474 REGULATION OF CARTILAGE DEVELOPMENT 15 63 0.0006718 0.006581
475 POSITIVE REGULATION OF JUN KINASE ACTIVITY 15 63 0.0006718 0.006581
476 REGULATION OF LIPASE ACTIVITY 18 83 0.0006853 0.006671
477 REGULATION OF PEPTIDE SECRETION 35 209 0.0006843 0.006671
478 LYMPHOCYTE DIFFERENTIATION 35 209 0.0006843 0.006671
479 CARDIAC CHAMBER MORPHOGENESIS 21 104 0.0007019 0.006789
480 MAGNESIUM ION TRANSPORT 6 13 0.0007006 0.006789
481 MESONEPHROS DEVELOPMENT 19 90 0.0007006 0.006789
482 NEGATIVE REGULATION OF TRANSPORT 65 458 0.0007044 0.0068
483 CELL PART MORPHOGENESIS 85 633 0.0007096 0.006836
484 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 49 323 0.0007208 0.006929
485 RESPONSE TO ESTROGEN 36 218 0.0007541 0.007235
486 REGULATION OF PHOSPHOLIPASE C ACTIVITY 11 39 0.0007631 0.007291
487 LONG TERM SYNAPTIC POTENTIATION 11 39 0.0007631 0.007291
488 DEVELOPMENTAL CELL GROWTH 17 77 0.0007707 0.007348
489 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 20 98 0.0008085 0.007636
490 ENSHEATHMENT OF NEURONS 19 91 0.0008078 0.007636
491 REGULATION OF KERATINOCYTE PROLIFERATION 9 28 0.0008107 0.007636
492 AXON ENSHEATHMENT 19 91 0.0008078 0.007636
493 LONG TERM MEMORY 9 28 0.0008107 0.007636
494 NEURONAL ACTION POTENTIAL 9 28 0.0008107 0.007636
495 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 35 211 0.000816 0.00767
496 POSITIVE REGULATION OF CELL CELL ADHESION 39 243 0.000823 0.00772
497 PHOSPHOLIPID BIOSYNTHETIC PROCESS 38 235 0.0008249 0.007723
498 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 23 120 0.0008604 0.008039
499 REGULATION OF SYNAPSE ORGANIZATION 22 113 0.0008881 0.008264
500 REGULATION OF STEM CELL DIFFERENTIATION 22 113 0.0008881 0.008264
501 NEGATIVE REGULATION OF GROWTH 38 236 0.000895 0.008312
502 POSITIVE REGULATION OF CALCIUM ION TRANSPORT 21 106 0.0009099 0.008417
503 CARDIAC VENTRICLE DEVELOPMENT 21 106 0.0009099 0.008417
504 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 10 34 0.0009193 0.00847
505 REGULATION OF PROTEIN DEACETYLATION 10 34 0.0009193 0.00847
506 LIPID PHOSPHORYLATION 20 99 0.0009242 0.008482
507 REGULATION OF LIPID CATABOLIC PROCESS 13 52 0.0009239 0.008482
508 HORMONE MEDIATED SIGNALING PATHWAY 28 158 0.0009276 0.008496
509 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 33 197 0.0009529 0.008711
510 PEPTIDYL THREONINE MODIFICATION 12 46 0.0009596 0.008755
511 ANTIGEN PROCESSING AND PRESENTATION 35 213 0.0009695 0.008828
512 REGULATION OF PROTEIN STABILITY 36 221 0.0009727 0.00884
513 DEPHOSPHORYLATION 44 286 0.0009801 0.00889
514 RESPONSE TO KETONE 31 182 0.001011 0.009149
515 CALCIUM ION TRANSMEMBRANE TRANSPORT 28 159 0.001026 0.009267
516 REGULATION OF BLOOD CIRCULATION 45 295 0.001034 0.009324
517 DENDRITE DEVELOPMENT 17 79 0.001046 0.00938
518 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 17 79 0.001046 0.00938
519 CELL CELL SIGNALING 99 767 0.001045 0.00938
520 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 19 93 0.001065 0.00953
521 ION TRANSMEMBRANE TRANSPORT 105 822 0.001067 0.00953
522 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 9 29 0.001077 0.009584
523 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 9 29 0.001077 0.009584
524 RESPONSE TO CYTOKINE 93 714 0.001101 0.009774
525 CIRCADIAN RHYTHM 25 137 0.001105 0.009777
526 SKELETAL MUSCLE ORGAN DEVELOPMENT 25 137 0.001105 0.009777
527 FOREBRAIN GENERATION OF NEURONS 15 66 0.001125 0.009863
528 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 14 0.001128 0.009863
529 POSITIVE REGULATION OF LONG TERM SYNAPTIC POTENTIATION 6 14 0.001128 0.009863
530 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 6 14 0.001128 0.009863
531 POSITIVE REGULATION OF LIPASE ACTIVITY 15 66 0.001125 0.009863
532 REGULATION OF SMOOTH MUSCLE CELL APOPTOTIC PROCESS 6 14 0.001128 0.009863
533 RESPONSE TO WOUNDING 76 563 0.001142 0.00997
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN KINASE ACTIVITY 122 640 4.303e-14 3.998e-11
2 KINASE ACTIVITY 145 842 7.66e-13 3.365e-10
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 189 1199 1.087e-12 3.365e-10
4 ENZYME BINDING 251 1737 2.89e-12 6.712e-10
5 ADENYL NUCLEOTIDE BINDING 220 1514 4.627e-11 8.597e-09
6 MOLECULAR FUNCTION REGULATOR 195 1353 1.315e-09 1.746e-07
7 ZINC ION BINDING 172 1155 1.186e-09 1.746e-07
8 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 107 629 1.753e-09 2.036e-07
9 RIBONUCLEOTIDE BINDING 251 1860 2.928e-09 3.023e-07
10 PROTEIN SERINE THREONINE KINASE ACTIVITY 82 445 3.595e-09 3.339e-07
11 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 150 992 5.251e-09 4.435e-07
12 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 64 328 2.025e-08 1.568e-06
13 MACROMOLECULAR COMPLEX BINDING 193 1399 4.904e-08 3.505e-06
14 DOUBLE STRANDED DNA BINDING 118 764 7.592e-08 5.038e-06
15 REGULATORY REGION NUCLEIC ACID BINDING 124 818 1.023e-07 5.848e-06
16 SEQUENCE SPECIFIC DNA BINDING 150 1037 9.647e-08 5.848e-06
17 RECEPTOR BINDING 200 1476 1.07e-07 5.848e-06
18 PROTEIN DOMAIN SPECIFIC BINDING 99 624 2.421e-07 1.249e-05
19 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 24 81 2.843e-07 1.322e-05
20 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 47 228 2.847e-07 1.322e-05
21 GROWTH FACTOR BINDING 31 123 3.292e-07 1.456e-05
22 SMAD BINDING 22 72 4.894e-07 2.066e-05
23 TRANSITION METAL ION BINDING 187 1400 7.704e-07 3.112e-05
24 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 56 303 9.596e-07 3.715e-05
25 PROTEIN COMPLEX BINDING 133 935 1.327e-06 4.932e-05
26 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 70 420 2.424e-06 8.341e-05
27 KINASE BINDING 93 606 2.424e-06 8.341e-05
28 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 19 64 4.685e-06 0.0001554
29 STEROID HORMONE RECEPTOR ACTIVITY 18 59 5.408e-06 0.0001733
30 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 25 101 6.235e-06 0.0001931
31 CYTOSKELETAL PROTEIN BINDING 116 819 7.78e-06 0.0002331
32 RECEPTOR SIGNALING PROTEIN ACTIVITY 35 172 1.21e-05 0.0003513
33 PHOSPHORIC ESTER HYDROLASE ACTIVITY 61 368 1.252e-05 0.0003525
34 ACTIN BINDING 64 393 1.381e-05 0.0003773
35 UBIQUITIN LIKE PROTEIN LIGASE ACTIVITY 38 199 2.397e-05 0.0006363
36 BHLH TRANSCRIPTION FACTOR BINDING 11 28 2.61e-05 0.0006735
37 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 53 315 2.99e-05 0.0007508
38 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 41 226 4.072e-05 0.00097
39 UBIQUITIN LIKE PROTEIN CONJUGATING ENZYME BINDING 12 34 3.969e-05 0.00097
40 VOLTAGE GATED ION CHANNEL ACTIVITY 36 190 4.601e-05 0.001032
41 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 33 168 4.473e-05 0.001032
42 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 65 417 4.779e-05 0.001032
43 ENZYME REGULATOR ACTIVITY 128 959 4.725e-05 0.001032
44 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 85 588 6.118e-05 0.001292
45 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 17 64 7.125e-05 0.001471
46 PROTEIN DIMERIZATION ACTIVITY 148 1149 7.345e-05 0.001483
47 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 14 48 0.0001021 0.002018
48 INSULIN RECEPTOR BINDING 11 32 0.0001096 0.002082
49 CHEMOREPELLENT ACTIVITY 10 27 0.0001098 0.002082
50 PROTEIN TYROSINE KINASE ACTIVITY 33 176 0.0001152 0.002141
51 ATP DEPENDENT MICROTUBULE MOTOR ACTIVITY 8 18 0.0001209 0.00216
52 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 27 133 0.0001196 0.00216
53 CAMP BINDING 9 23 0.0001487 0.002606
54 MICROTUBULE BINDING 36 201 0.0001522 0.002618
55 TRANSMEMBRANE TRANSPORTER ACTIVITY 129 997 0.0001754 0.002962
56 ENZYME ACTIVATOR ACTIVITY 69 471 0.0001966 0.003261
57 TRANSCRIPTION COACTIVATOR BINDING 6 11 0.0002231 0.003574
58 HIGH VOLTAGE GATED CALCIUM CHANNEL ACTIVITY 6 11 0.0002231 0.003574
59 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 17 70 0.0002347 0.003696
60 CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 86 622 0.0002586 0.003959
61 MICROTUBULE MOTOR ACTIVITY 18 77 0.0002599 0.003959
62 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 8 20 0.0002925 0.004383
63 CYCLIC NUCLEOTIDE BINDING 11 36 0.0003572 0.005109
64 CALMODULIN BINDING 32 179 0.0003562 0.005109
65 TUBULIN BINDING 44 273 0.000362 0.005109
66 TRANSCRIPTION FACTOR BINDING 74 524 0.0003634 0.005109
67 MAGNESIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 7 16 0.0003685 0.005109
68 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 19 86 0.0003847 0.005182
69 CATION CHANNEL ACTIVITY 47 298 0.0003849 0.005182
70 THIOL DEPENDENT UBIQUITIN SPECIFIC PROTEASE ACTIVITY 17 73 0.0004002 0.005311
71 CORE PROMOTER BINDING 28 152 0.000493 0.00645
72 PHOSPHOLIPID BINDING 54 360 0.0005253 0.006778
73 CYTOKINE RECEPTOR ACTIVITY 19 89 0.0006058 0.007709
74 CORE PROMOTER PROXIMAL REGION DNA BINDING 55 371 0.0006255 0.007852
75 LIGASE ACTIVITY 59 406 0.0006754 0.008366
76 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 31 178 0.0006912 0.008449
77 PHOSPHORIC DIESTER HYDROLASE ACTIVITY 19 90 0.0007006 0.008452
78 IDENTICAL PROTEIN BINDING 148 1209 0.0007399 0.008812
79 CALCIUM ION BINDING 92 697 0.000767 0.009019
80 BETA CATENIN BINDING 18 84 0.0007959 0.009064
81 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 21 105 0.0008001 0.009064
82 TRANSPORTER ACTIVITY 155 1276 0.0007809 0.009064
83 R SMAD BINDING 8 23 0.0008781 0.009828
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 198 1265 5.836e-13 1.832e-10
2 NEURON PROJECTION 158 942 6.274e-13 1.832e-10
3 SYNAPSE 131 754 5.509e-12 1.072e-09
4 SOMATODENDRITIC COMPARTMENT 110 650 1.399e-09 2.042e-07
5 POSTSYNAPSE 73 378 3.306e-09 3.862e-07
6 GOLGI APPARATUS 202 1445 8.077e-09 7.862e-07
7 AXON 77 418 1.091e-08 7.967e-07
8 SYNAPSE PART 102 610 1.067e-08 7.967e-07
9 CELL PROJECTION 239 1786 1.563e-08 1.014e-06
10 EXCITATORY SYNAPSE 44 197 6.136e-08 3.583e-06
11 SITE OF POLARIZED GROWTH 36 149 1.211e-07 6.431e-06
12 DENDRITE 75 451 1.167e-06 5.681e-05
13 INTRACELLULAR VESICLE 170 1259 1.298e-06 5.831e-05
14 PERINUCLEAR REGION OF CYTOPLASM 98 642 1.659e-06 6.459e-05
15 ENDOSOME 116 793 1.646e-06 6.459e-05
16 CELL PROJECTION PART 132 946 4.013e-06 0.0001465
17 CYTOPLASMIC REGION 51 287 9.141e-06 0.000314
18 CELL CORTEX 44 238 1.335e-05 0.0004333
19 VESICLE MEMBRANE 78 512 2.013e-05 0.0004898
20 INTRINSIC COMPONENT OF PLASMA MEMBRANE 206 1649 1.986e-05 0.0004898
21 PROTEINACEOUS EXTRACELLULAR MATRIX 59 356 1.736e-05 0.0004898
22 CELL BODY 76 494 1.815e-05 0.0004898
23 AXON PART 41 219 1.905e-05 0.0004898
24 PLASMA MEMBRANE PROTEIN COMPLEX 78 510 1.75e-05 0.0004898
25 NEURON SPINE 27 121 2.11e-05 0.0004929
26 CELL JUNCTION 151 1151 2.451e-05 0.0005506
27 KINESIN COMPLEX 16 55 3.447e-05 0.0007455
28 MEMBRANE REGION 148 1134 3.84e-05 0.000801
29 RECEPTOR COMPLEX 54 327 4.279e-05 0.0008617
30 CYTOPLASMIC VESICLE PART 87 601 4.786e-05 0.0009316
31 EXTRACELLULAR MATRIX 66 426 5.07e-05 0.0009552
32 ENDOSOMAL PART 66 430 6.763e-05 0.001234
33 VOLTAGE GATED SODIUM CHANNEL COMPLEX 7 14 0.0001312 0.002322
34 GOLGI MEMBRANE 96 703 0.0001829 0.003142
35 GOLGI APPARATUS PART 117 893 0.0002122 0.003442
36 PLASMA MEMBRANE REGION 121 929 0.0002118 0.003442
37 VACUOLE 148 1180 0.000256 0.00404
38 EXTRACELLULAR MATRIX COMPONENT 25 125 0.0002677 0.004114
39 VACUOLAR MEMBRANE 81 587 0.0004101 0.006141
40 CATION CHANNEL COMPLEX 30 167 0.0004923 0.007188
41 SODIUM CHANNEL COMPLEX 7 17 0.0005751 0.008192
42 MICROTUBULE 59 405 0.0006347 0.008621
43 MEMBRANE MICRODOMAIN 45 288 0.0006204 0.008621

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 67 295 1.073e-11 5.581e-10
2 PI3K_Akt_signaling_pathway_hsa04151 68 352 1.121e-08 2.914e-07
3 Focal_adhesion_hsa04510 45 199 2.944e-08 5.103e-07
4 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 32 139 1.862e-06 2.421e-05
5 FoxO_signaling_pathway_hsa04068 30 132 5.095e-06 5.299e-05
6 cGMP_PKG_signaling_pathway_hsa04022 34 163 9.204e-06 7.976e-05
7 Ras_signaling_pathway_hsa04014 43 232 1.561e-05 0.0001159
8 Rap1_signaling_pathway_hsa04015 39 206 2.312e-05 0.0001503
9 Phospholipase_D_signaling_pathway_hsa04072 30 146 4.067e-05 0.000235
10 TNF_signaling_pathway_hsa04668 24 108 6.362e-05 0.0003308
11 Calcium_signaling_pathway_hsa04020 34 182 9.866e-05 0.0004664
12 Endocytosis_hsa04144 42 244 0.0001142 0.0004948
13 AMPK_signaling_pathway_hsa04152 25 121 0.0001572 0.0006288
14 mTOR_signaling_pathway_hsa04150 29 151 0.0001897 0.0006955
15 ECM_receptor_interaction_hsa04512 19 82 0.0002006 0.0006955
16 Cellular_senescence_hsa04218 30 160 0.0002304 0.0007487
17 TGF_beta_signaling_pathway_hsa04350 19 84 0.0002797 0.0008556
18 Phosphatidylinositol_signaling_system_hsa04070 21 99 0.0003515 0.001015
19 HIF_1_signaling_pathway_hsa04066 21 100 0.0004057 0.00111
20 cAMP_signaling_pathway_hsa04024 34 198 0.0005108 0.001285
21 p53_signaling_pathway_hsa04115 16 68 0.0005189 0.001285
22 Hippo_signaling_pathway_multiple_species_hsa04392 9 29 0.001077 0.002499
23 Apelin_signaling_pathway_hsa04371 25 137 0.001105 0.002499
24 Regulation_of_actin_cytoskeleton_hsa04810 34 208 0.001246 0.002651
25 Wnt_signaling_pathway_hsa04310 26 146 0.001288 0.002651
26 Oocyte_meiosis_hsa04114 23 124 0.001366 0.002651
27 Jak_STAT_signaling_pathway_hsa04630 28 162 0.001376 0.002651
28 Cell_adhesion_molecules_.CAMs._hsa04514 25 145 0.002497 0.004638
29 Hippo_signaling_pathway_hsa04390 26 154 0.002798 0.005018
30 Hedgehog_signaling_pathway_hsa04340 11 47 0.003908 0.006773
31 Autophagy_animal_hsa04140 22 128 0.004553 0.007638
32 Cytokine_cytokine_receptor_interaction_hsa04060 39 270 0.005587 0.009079
33 Sphingolipid_signaling_pathway_hsa04071 20 118 0.00774 0.0122
34 Adherens_junction_hsa04520 13 72 0.01739 0.02659
35 Gap_junction_hsa04540 15 88 0.01845 0.02741
36 ABC_transporters_hsa02010 9 45 0.02396 0.03461
37 ErbB_signaling_pathway_hsa04012 14 85 0.0292 0.04104
38 Mitophagy_animal_hsa04137 11 65 0.04181 0.05721
39 VEGF_signaling_pathway_hsa04370 10 59 0.05036 0.06715
40 Tight_junction_hsa04530 22 170 0.08522 0.1108
41 Notch_signaling_pathway_hsa04330 7 48 0.1677 0.2127
42 NF_kappa_B_signaling_pathway_hsa04064 12 95 0.1905 0.2358
43 Cell_cycle_hsa04110 15 124 0.1996 0.2372
44 Apoptosis_multiple_species_hsa04215 5 33 0.2007 0.2372
45 Apoptosis_hsa04210 16 138 0.2388 0.2759
46 Phagosome_hsa04145 17 152 0.2775 0.3137
47 Peroxisome_hsa04146 9 83 0.3922 0.434
48 Ferroptosis_hsa04216 4 40 0.5362 0.5808
49 Necroptosis_hsa04217 14 164 0.7045 0.7476
50 Neuroactive_ligand_receptor_interaction_hsa04080 23 278 0.7894 0.821
51 Autophagy_other_hsa04136 2 32 0.8222 0.8383
52 Lysosome_hsa04142 8 123 0.9087 0.9087

Quest ID: e2b8192a7aed29f72f59ff8994f27901