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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7b-5p AIFM1 -0.19 0.65188 0.57 0.10576 miRNATAP -0.16 0.0007 NA
2 hsa-miR-125b-5p AKT1 -2.01 0.00516 0.11 0.66561 miRNAWalker2 validate; miRTarBase -0.05 0.00588 NA
3 hsa-miR-214-3p AKT2 -0.01 0.98584 -0.09 0.77127 mirMAP -0.05 0.01027 NA
4 hsa-miR-106a-5p AKT3 3.99 0 -3.33 1.0E-5 miRNATAP -0.12 0.02117 NA
5 hsa-miR-106b-5p AKT3 2.81 0 -3.33 1.0E-5 miRNATAP -0.41 1.0E-5 NA
6 hsa-miR-142-3p AKT3 4.35 0 -3.33 1.0E-5 miRanda -0.16 0.00934 NA
7 hsa-miR-15a-5p AKT3 2.05 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.00021 NA
8 hsa-miR-15b-5p AKT3 3.32 0 -3.33 1.0E-5 miRNATAP -0.25 0.00571 NA
9 hsa-miR-16-5p AKT3 2.94 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.31 0.00086 NA
10 hsa-miR-17-5p AKT3 2.33 2.0E-5 -3.33 1.0E-5 TargetScan; miRNATAP -0.17 0.02914 NA
11 hsa-miR-20b-5p AKT3 4.57 5.0E-5 -3.33 1.0E-5 miRNATAP -0.09 0.01499 NA
12 hsa-miR-29b-2-5p AKT3 -0.6 0.18954 -3.33 1.0E-5 mirMAP -0.23 0.01747 NA
13 hsa-miR-29b-3p AKT3 0.67 0.23406 -3.33 1.0E-5 miRNATAP -0.28 0.00031 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
14 hsa-miR-3065-5p AKT3 2.14 0.06094 -3.33 1.0E-5 mirMAP -0.22 0 NA
15 hsa-miR-362-3p AKT3 0.68 0.22615 -3.33 1.0E-5 miRanda -0.25 0.00124 NA
16 hsa-miR-501-3p AKT3 1.72 0.00759 -3.33 1.0E-5 miRNATAP -0.18 0.00733 NA
17 hsa-miR-502-3p AKT3 -0.1 0.80889 -3.33 1.0E-5 miRNATAP -0.23 0.03065 NA
18 hsa-miR-93-5p AKT3 2.66 0 -3.33 1.0E-5 miRNATAP -0.33 0.00021 NA
19 hsa-miR-155-5p APAF1 2.81 7.0E-5 0.35 0.33131 miRNAWalker2 validate -0.11 0.0002 22996741; 26877850 MiR 155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf 1 expression; The objective of this study is to verify the hypothesis based on the results of bioinformatics analysis that miR-155 modulates cellular apoptosis and DNA damage through the regulation of Apaf-1 and is thus involved in the development and progression of lung cancer; First we measured the expression of miR-155 and the Apaf-1 protein in lung cancer tissues; The results showed that expression of miR-155 was significantly higher in lung cancer tissues than in paracancerous and normal tissues; whereas Apaf-1 expression was lower in the lung cancerous tissues; The results showed that relative to controls the silencing of miR-155 resulted in elevated expression of the Apaf-1 protein whereas Apaf-1 mRNA levels remained unchanged; Both the silencing of miR-155 and the overexpression Apaf-1 greatly increased the sensitivity of A549 cells to cisplatin treatment as evidenced by elevated rates of apoptosis and DNA damage; Furthermore dual-transfection of A549 cells with miR-155 siRNA and Apaf-1 siRNA resulted in the attenuation of apoptosis and DNA damage;Also increase in the transcript level of APAF-1 and CASP-9 after downregulation of miR-21 and miR-155 might indicate that these genes were targeted by aforementioned miRNAs in T47D cells
20 hsa-miR-23a-3p APAF1 0.93 0.01273 0.35 0.33131 miRNATAP -0.25 1.0E-5 24992592; 24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed
21 hsa-miR-23b-3p APAF1 -0.58 0.19048 0.35 0.33131 miRNATAP -0.16 0.00048 NA
22 hsa-miR-27a-3p APAF1 1.76 0.00022 0.35 0.33131 miRNATAP -0.18 3.0E-5 NA
23 hsa-miR-27b-3p APAF1 -0.09 0.85847 0.35 0.33131 miRNATAP -0.16 6.0E-5 NA
24 hsa-miR-33a-3p APAF1 2.06 0.00156 0.35 0.33131 mirMAP -0.06 0.0393 NA
25 hsa-miR-374b-5p APAF1 -0.11 0.76489 0.35 0.33131 mirMAP -0.13 0.01531 NA
26 hsa-miR-590-3p APAF1 2.35 0 0.35 0.33131 PITA; miRanda; mirMAP; miRNATAP -0.12 0.0034 NA
27 hsa-miR-590-5p APAF1 1.51 0.00239 0.35 0.33131 miRanda -0.1 0.01383 NA
28 hsa-miR-664a-3p APAF1 0.25 0.56171 0.35 0.33131 mirMAP -0.11 0.01914 NA
29 hsa-miR-708-3p APAF1 0.78 0.29065 0.35 0.33131 mirMAP -0.12 2.0E-5 NA
30 hsa-miR-18a-5p ATM 3.91 0 -0.66 0.11688 miRNAWalker2 validate; miRTarBase; MirTarget -0.1 0.00848 25963391; 23437304; 23857602; 23229340 However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
31 hsa-miR-19b-3p ATM 1.68 0.00086 -0.66 0.11688 miRNAWalker2 validate -0.1 0.04453 NA
32 hsa-miR-203a-3p ATM 6.35 0 -0.66 0.11688 MirTarget -0.11 0 24145123; 27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression
33 hsa-miR-27a-5p ATM 1.45 0.03942 -0.66 0.11688 MirTarget -0.12 0.00046 NA
34 hsa-miR-30e-3p ATM -0.04 0.93258 -0.66 0.11688 mirMAP -0.16 0.0051 NA
35 hsa-miR-335-3p ATM 1.2 0.09389 -0.66 0.11688 mirMAP -0.07 0.02605 NA
36 hsa-miR-339-5p ATM 1.23 0.03075 -0.66 0.11688 miRanda -0.16 0.00017 NA
37 hsa-miR-34c-5p ATM 2.65 0.01574 -0.66 0.11688 miRanda -0.05 0.01287 NA
38 hsa-miR-590-3p ATM 2.35 0 -0.66 0.11688 miRanda; mirMAP -0.12 0.01272 NA
39 hsa-miR-590-5p ATM 1.51 0.00239 -0.66 0.11688 mirMAP -0.13 0.00485 NA
40 hsa-miR-92a-3p ATM 1.88 1.0E-5 -0.66 0.11688 miRNAWalker2 validate -0.14 0.01126 NA
41 hsa-miR-944 ATM 7.21 0.00082 -0.66 0.11688 mirMAP -0.08 0 NA
42 hsa-miR-127-3p BAD -1.38 0.0732 -0.43 0.27401 miRanda; miRNATAP -0.06 0.04432 NA
43 hsa-miR-15b-3p BCL2 3.58 0 -3.06 1.0E-5 mirMAP -0.16 0.0243 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
44 hsa-miR-15b-5p BCL2 3.32 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase -0.18 0.02793 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
45 hsa-miR-16-2-3p BCL2 3.8 0 -3.06 1.0E-5 mirMAP -0.2 0.00813 NA
46 hsa-miR-16-5p BCL2 2.94 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase -0.27 0.00125 21336967; 24447552; 18449891; 25435430; 24598659; 18931683; 22966344; 25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells
47 hsa-miR-192-5p BCL2 1.78 0.11349 -3.06 1.0E-5 miRNAWalker2 validate -0.13 0.00025 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
48 hsa-miR-200a-5p BCL2 6.52 0 -3.06 1.0E-5 mirMAP -0.2 0.00037 NA
49 hsa-miR-200b-3p BCL2 5.56 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase; TargetScan; mirMAP -0.11 0.03933 NA
50 hsa-miR-200b-5p BCL2 6.82 0 -3.06 1.0E-5 mirMAP -0.2 0.00019 NA
51 hsa-miR-200c-3p BCL2 6.47 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase; mirMAP -0.2 0.00073 NA
52 hsa-miR-20a-3p BCL2 1.99 0.00062 -3.06 1.0E-5 mirMAP -0.16 0.0222 NA
53 hsa-miR-21-5p BCL2 2.65 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase -0.48 4.0E-5 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
54 hsa-miR-215-5p BCL2 3.67 0.00295 -3.06 1.0E-5 miRNAWalker2 validate -0.14 1.0E-5 NA
55 hsa-miR-24-2-5p BCL2 2.07 6.0E-5 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase -0.36 0 NA
56 hsa-miR-3065-5p BCL2 2.14 0.06094 -3.06 1.0E-5 mirMAP -0.17 0.00011 NA
57 hsa-miR-32-3p BCL2 2.2 0.03928 -3.06 1.0E-5 mirMAP -0.16 0.01564 NA
58 hsa-miR-338-5p BCL2 -0.11 0.89468 -3.06 1.0E-5 PITA -0.15 0.00173 NA
59 hsa-miR-33b-5p BCL2 4.78 0 -3.06 1.0E-5 miRTarBase; mirMAP -0.12 0.00899 NA
60 hsa-miR-365a-3p BCL2 0.26 0.65432 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase -0.39 0 NA
61 hsa-miR-375 BCL2 3.38 0.04499 -3.06 1.0E-5 miRNAWalker2 validate -0.06 0.01035 26381132; 26697569; 25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated
62 hsa-miR-429 BCL2 6.4 0 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase; PITA; mirMAP -0.16 0.00181 23999873; 26513239; 26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation
63 hsa-miR-451a BCL2 0.95 0.43831 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase -0.07 0.04266 26516138; 23053883 Western blot was used for the detection of the protein expression of Bcl-2 and Caspase 3 after the transfection of miR-451 mimics /inhibitors; Bioinformatics analysis demonstrated that Bcl-2 protein is a potential target gene for miR-451; Increased miR-451 expression may negatively regulate Bcl-2 mRNA and protein expression followed by affecting the protein expression of caspase 3 and accelerate the apoptosis in breast cancer indicating that miR-451 might influence the drug resistances of the Paclitaxel-resistant breast cancer cell line;The expression of miR-451 was analyzed by RT-PCR and the expressions of Bcl-2 AKT and phosphorylated AKT were analyzed by Western blotting; In comparison to the controls a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2 AKT and p-AKT and a significant increase in the apoptosis rate
64 hsa-miR-582-5p BCL2 0.69 0.44776 -3.06 1.0E-5 PITA -0.13 0.00231 NA
65 hsa-miR-590-5p BCL2 1.51 0.00239 -3.06 1.0E-5 miRanda -0.17 0.03245 NA
66 hsa-miR-629-5p BCL2 1.57 0.01157 -3.06 1.0E-5 mirMAP -0.25 7.0E-5 NA
67 hsa-miR-7-5p BCL2 3.6 0.00068 -3.06 1.0E-5 miRNAWalker2 validate; miRTarBase; mirMAP -0.12 0.00725 26464649; 25862909; 21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions
68 hsa-let-7a-5p BCL2L1 0.15 0.64531 0.39 0.37256 TargetScan; miRNATAP -0.2 0.01274 26915294; 20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA
69 hsa-miR-23b-3p BCL2L1 -0.58 0.19048 0.39 0.37256 miRNAWalker2 validate -0.11 0.04171 NA
70 hsa-miR-342-3p BCL2L1 1.31 0.02072 0.39 0.37256 PITA; miRanda; miRNATAP -0.13 0.00344 NA
71 hsa-miR-342-5p BCL2L1 1.39 0.01536 0.39 0.37256 miRNATAP -0.1 0.01901 NA
72 hsa-miR-195-3p BIRC3 -2.39 0.00019 0.15 0.88569 mirMAP -0.22 0.01884 NA
73 hsa-miR-20b-3p BIRC3 3.33 0.06324 0.15 0.88569 MirTarget -0.13 0.02697 NA
74 hsa-miR-24-1-5p BIRC3 -0.64 0.23613 0.15 0.88569 MirTarget -0.36 0.00121 NA
75 hsa-miR-369-3p BIRC3 0.37 0.63876 0.15 0.88569 MirTarget; miRNATAP -0.15 0.04648 NA
76 hsa-miR-664a-3p BIRC3 0.25 0.56171 0.15 0.88569 mirMAP -0.28 0.04632 NA
77 hsa-miR-491-5p CAPN1 0.57 0.31331 1.31 0.00019 miRanda -0.15 5.0E-5 NA
78 hsa-miR-107 CAPN2 1.49 0.00013 0.65 0.13872 miRanda -0.13 0.04866 NA
79 hsa-miR-1468-5p CAPN2 -1.63 0.00779 0.65 0.13872 MirTarget -0.2 0 NA
80 hsa-miR-20a-3p CAPN2 1.99 0.00062 0.65 0.13872 MirTarget -0.14 0.00093 NA
81 hsa-miR-30a-5p CAPN2 -0.77 0.32049 0.65 0.13872 miRNAWalker2 validate -0.08 0.01733 NA
82 hsa-miR-421 CAPN2 1.98 0.00092 0.65 0.13872 miRanda -0.11 0.00888 NA
83 hsa-miR-125b-5p CASP10 -2.01 0.00516 0.7 0.33671 mirMAP -0.15 0.00696 NA
84 hsa-miR-129-5p CASP10 -2.67 0.00696 0.7 0.33671 mirMAP -0.1 0.02215 NA
85 hsa-miR-145-3p CASP10 -2.96 0 0.7 0.33671 mirMAP -0.15 0.02154 NA
86 hsa-miR-145-5p CASP10 -3.56 0 0.7 0.33671 mirMAP -0.14 0.01213 NA
87 hsa-miR-186-5p CASP10 0.45 0.18545 0.7 0.33671 MirTarget; mirMAP -0.26 0.04094 NA
88 hsa-miR-19b-3p CASP10 1.68 0.00086 0.7 0.33671 MirTarget; mirMAP -0.2 0.01385 NA
89 hsa-miR-33a-3p CASP10 2.06 0.00156 0.7 0.33671 mirMAP -0.16 0.01181 NA
90 hsa-miR-361-5p CASP10 0.01 0.9852 0.7 0.33671 miRanda -0.46 0.00011 NA
91 hsa-miR-429 CASP10 6.4 0 0.7 0.33671 mirMAP; miRNATAP -0.13 0.01667 NA
92 hsa-miR-501-5p CASP10 1.04 0.07772 0.7 0.33671 mirMAP -0.16 0.01989 NA
93 hsa-miR-532-5p CASP10 -0.3 0.50393 0.7 0.33671 mirMAP -0.47 0 NA
94 hsa-miR-589-3p CASP10 1.33 0.05263 0.7 0.33671 mirMAP -0.23 0.00013 NA
95 hsa-miR-592 CASP10 2.8 0.02935 0.7 0.33671 miRNATAP -0.1 0.0073 NA
96 hsa-miR-744-3p CASP10 1.08 0.13124 0.7 0.33671 mirMAP -0.39 0 NA
97 hsa-miR-129-5p CASP3 -2.67 0.00696 0.93 0.00553 mirMAP -0.05 0.00602 23744359 The intrinsic apoptotic pathway triggered by miR-129 was activated by cleavage of caspase-9 and caspase-3
98 hsa-miR-193b-5p CASP3 0.45 0.56588 0.93 0.00553 MirTarget -0.09 0.00034 NA
99 hsa-miR-23a-3p CASP7 0.93 0.01273 0.55 0.21498 MirTarget -0.16 0.02185 NA
100 hsa-miR-335-5p CASP7 0.17 0.8039 0.55 0.21498 MirTarget -0.1 0.01049 NA
101 hsa-miR-361-5p CASP7 0.01 0.9852 0.55 0.21498 PITA; miRanda -0.2 0.00762 NA
102 hsa-miR-664a-3p CASP7 0.25 0.56171 0.55 0.21498 MirTarget -0.14 0.02009 NA
103 hsa-miR-217 CASP8 -0.38 0.71741 1.38 0.00022 miRanda -0.06 0.00539 NA
104 hsa-miR-455-5p CASP8 -0.32 0.6163 1.38 0.00022 miRanda -0.09 0.00884 NA
105 hsa-miR-222-5p CASP9 2.52 0.00142 -0.46 0.19687 mirMAP -0.08 0.0009 NA
106 hsa-miR-125a-5p CFLAR -1.32 0.00714 0.11 0.78588 miRanda -0.13 0.0064 NA
107 hsa-miR-130b-3p CFLAR 3.92 0 0.11 0.78588 mirMAP -0.14 0.00031 NA
108 hsa-miR-15b-5p CFLAR 3.32 0 0.11 0.78588 mirMAP -0.1 0.03067 NA
109 hsa-miR-301a-3p CFLAR 1.99 0.00081 0.11 0.78588 mirMAP -0.14 0.00017 NA
110 hsa-miR-30b-3p CFLAR 0.17 0.76608 0.11 0.78588 mirMAP -0.16 7.0E-5 NA
111 hsa-miR-497-5p CFLAR -1.44 0.02251 0.11 0.78588 mirMAP -0.08 0.03415 NA
112 hsa-miR-708-5p CFLAR 1.7 0.03195 0.11 0.78588 mirMAP -0.06 0.02422 NA
113 hsa-miR-9-5p CFLAR 1.8 0.14527 0.11 0.78588 mirMAP -0.07 0.00032 NA
114 hsa-miR-582-5p CHP2 0.69 0.44776 1.48 0.50956 miRNATAP -0.42 0.00313 NA
115 hsa-miR-195-5p CHUK -1.59 0.01691 0.41 0.12085 miRNAWalker2 validate; MirTarget -0.05 0.02493 NA
116 hsa-miR-497-5p CHUK -1.44 0.02251 0.41 0.12085 MirTarget -0.07 0.00184 NA
117 hsa-miR-15b-3p CSF2RB 3.58 0 -0.53 0.5247 mirMAP -0.24 0.00379 NA
118 hsa-miR-19b-3p CSF2RB 1.68 0.00086 -0.53 0.5247 MirTarget -0.25 0.00793 NA
119 hsa-miR-30b-3p CSF2RB 0.17 0.76608 -0.53 0.5247 MirTarget -0.28 0.00087 NA
120 hsa-miR-532-5p CSF2RB -0.3 0.50393 -0.53 0.5247 MirTarget -0.22 0.0443 NA
121 hsa-miR-30a-3p DFFA -1.22 0.16757 0.34 0.23076 mirMAP -0.06 0.00088 NA
122 hsa-miR-3913-5p DFFA 0.15 0.73484 0.34 0.23076 mirMAP -0.08 0.03385 NA
123 hsa-miR-628-5p DFFA 1.05 0.02524 0.34 0.23076 mirMAP -0.07 0.03581 NA
124 hsa-miR-365a-3p DFFB 0.26 0.65432 -0.13 0.73678 MirTarget -0.1 0.00471 NA
125 hsa-miR-130b-3p ENDOD1 3.92 0 -1.15 0.01857 MirTarget -0.12 0.00768 NA
126 hsa-miR-16-1-3p ENDOD1 2.83 0 -1.15 0.01857 mirMAP -0.14 0.01455 NA
127 hsa-miR-181a-5p ENDOD1 1.26 0.00749 -1.15 0.01857 MirTarget -0.19 0.00156 NA
128 hsa-miR-181b-5p ENDOD1 1.11 0.02734 -1.15 0.01857 MirTarget -0.12 0.02423 NA
129 hsa-miR-181c-5p ENDOD1 -0.3 0.53753 -1.15 0.01857 MirTarget -0.19 0.00075 NA
130 hsa-miR-192-5p ENDOD1 1.78 0.11349 -1.15 0.01857 miRNAWalker2 validate -0.09 0.00044 NA
131 hsa-miR-19a-3p ENDOD1 2.17 0.00122 -1.15 0.01857 mirMAP -0.12 0.00261 NA
132 hsa-miR-19b-3p ENDOD1 1.68 0.00086 -1.15 0.01857 mirMAP -0.16 0.0036 NA
133 hsa-miR-200b-3p ENDOD1 5.56 0 -1.15 0.01857 TargetScan -0.13 0.00092 NA
134 hsa-miR-20a-3p ENDOD1 1.99 0.00062 -1.15 0.01857 MirTarget -0.1 0.0432 NA
135 hsa-miR-26b-3p ENDOD1 0.99 0.03514 -1.15 0.01857 mirMAP -0.15 0.00987 NA
136 hsa-miR-301a-3p ENDOD1 1.99 0.00081 -1.15 0.01857 MirTarget -0.13 0.00488 NA
137 hsa-miR-3607-3p ENDOD1 1.38 0.02401 -1.15 0.01857 MirTarget; miRNATAP -0.11 0.01385 NA
138 hsa-miR-3613-5p ENDOD1 4.05 0 -1.15 0.01857 MirTarget -0.2 4.0E-5 NA
139 hsa-miR-362-3p ENDOD1 0.68 0.22615 -1.15 0.01857 miRanda -0.18 0.00023 NA
140 hsa-miR-429 ENDOD1 6.4 0 -1.15 0.01857 miRanda; miRNATAP -0.1 0.00627 NA
141 hsa-miR-454-3p ENDOD1 1.4 0.00366 -1.15 0.01857 MirTarget -0.23 4.0E-5 NA
142 hsa-miR-589-3p ENDOD1 1.33 0.05263 -1.15 0.01857 mirMAP -0.1 0.0115 NA
143 hsa-miR-589-5p ENDOD1 1.56 0.00033 -1.15 0.01857 MirTarget -0.18 0.0056 NA
144 hsa-miR-590-3p ENDOD1 2.35 0 -1.15 0.01857 miRanda -0.22 7.0E-5 NA
145 hsa-miR-149-5p EXOG 1.19 0.19744 -0.06 0.85895 MirTarget -0.06 0.00548 NA
146 hsa-miR-24-3p EXOG 1.56 0.00052 -0.06 0.85895 MirTarget -0.14 0.00075 NA
147 hsa-miR-106a-5p FAS 3.99 0 -0.34 0.58934 miRNAWalker2 validate; miRTarBase -0.14 0.00128 22431000; 27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway
148 hsa-miR-361-5p FAS 0.01 0.9852 -0.34 0.58934 miRanda -0.33 0.00172 NA
149 hsa-miR-590-5p FAS 1.51 0.00239 -0.34 0.58934 miRanda -0.2 0.00636 NA
150 hsa-let-7e-5p FASLG -0.11 0.81474 1.93 0.09085 miRNATAP -0.31 0.02416 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 48 1929 3.965e-34 1.845e-30
2 INTRACELLULAR SIGNAL TRANSDUCTION 44 1572 1.267e-32 2.948e-29
3 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 45 1848 6.185e-31 9.594e-28
4 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 19 99 5.045e-29 5.868e-26
5 REGULATION OF CELL DEATH 40 1472 1.668e-28 1.552e-25
6 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 40 1492 2.802e-28 2.173e-25
7 CELL DEATH 35 1001 4.883e-28 3.246e-25
8 POSITIVE REGULATION OF CELL COMMUNICATION 40 1532 7.735e-28 4.499e-25
9 POSITIVE REGULATION OF MOLECULAR FUNCTION 42 1791 1.115e-27 5.763e-25
10 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 21 179 2.656e-27 1.124e-24
11 RESPONSE TO CYTOKINE 31 714 2.543e-27 1.124e-24
12 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 40 1656 1.515e-26 5.876e-24
13 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 22 233 1.797e-26 6.432e-24
14 NEGATIVE REGULATION OF CELL DEATH 32 872 5.232e-26 1.739e-23
15 APOPTOTIC SIGNALING PATHWAY 23 289 5.906e-26 1.754e-23
16 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 32 876 6.031e-26 1.754e-23
17 RESPONSE TO OXYGEN CONTAINING COMPOUND 37 1381 9.299e-26 2.545e-23
18 IMMUNE SYSTEM PROCESS 41 1984 9.968e-25 2.577e-22
19 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 13 39 1.473e-23 3.608e-21
20 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 19 213 2.258e-22 5.254e-20
21 POSITIVE REGULATION OF CATALYTIC ACTIVITY 35 1518 5.444e-22 1.206e-19
22 REGULATION OF IMMUNE SYSTEM PROCESS 34 1403 5.855e-22 1.238e-19
23 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 15 95 1.259e-21 2.547e-19
24 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 15 98 2.069e-21 4.011e-19
25 CELLULAR RESPONSE TO CYTOKINE STIMULUS 25 606 3.395e-21 6.318e-19
26 RESPONSE TO NITROGEN COMPOUND 28 859 4.091e-21 7.321e-19
27 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 27 799 1.021e-20 1.76e-18
28 ZYMOGEN ACTIVATION 15 112 1.717e-20 2.854e-18
29 REGULATION OF IMMUNE RESPONSE 27 858 6.405e-20 1.028e-17
30 POSITIVE REGULATION OF IMMUNE RESPONSE 23 563 2.339e-19 3.628e-17
31 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 19 321 5.665e-19 8.503e-17
32 CYTOKINE MEDIATED SIGNALING PATHWAY 21 452 8.576e-19 1.247e-16
33 POSITIVE REGULATION OF CELL DEATH 23 605 1.154e-18 1.627e-16
34 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 26 867 1.257e-18 1.721e-16
35 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 15 153 2.194e-18 2.917e-16
36 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 15 154 2.425e-18 3.135e-16
37 REGULATION OF RESPONSE TO STRESS 31 1468 4.522e-18 5.687e-16
38 ACTIVATION OF IMMUNE RESPONSE 20 427 5.742e-18 7.031e-16
39 POSITIVE REGULATION OF DEFENSE RESPONSE 19 364 5.965e-18 7.117e-16
40 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 28 1135 6.464e-18 7.519e-16
41 REGULATION OF PHOSPHORUS METABOLIC PROCESS 32 1618 6.936e-18 7.871e-16
42 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 1036 7.802e-18 8.443e-16
43 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 1036 7.802e-18 8.443e-16
44 CELLULAR RESPONSE TO NITROGEN COMPOUND 21 505 8.215e-18 8.688e-16
45 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 14 132 1.069e-17 1.105e-15
46 PROTEIN MATURATION 17 265 1.333e-17 1.348e-15
47 REGULATION OF KINASE ACTIVITY 24 776 1.918e-17 1.899e-15
48 REGULATION OF PEPTIDASE ACTIVITY 19 392 2.366e-17 2.293e-15
49 RESPONSE TO BIOTIC STIMULUS 25 886 2.951e-17 2.802e-15
50 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 16 228 3.217e-17 2.994e-15
51 RESPONSE TO ENDOGENOUS STIMULUS 30 1450 3.492e-17 3.186e-15
52 REGULATION OF PROTEOLYSIS 23 711 4.003e-17 3.581e-15
53 POSITIVE REGULATION OF KINASE ACTIVITY 20 482 6.02e-17 5.285e-15
54 RESPONSE TO ABIOTIC STIMULUS 26 1024 7.301e-17 6.291e-15
55 REGULATION OF APOPTOTIC SIGNALING PATHWAY 18 363 1.252e-16 1.059e-14
56 PROTEIN PHOSPHORYLATION 25 944 1.302e-16 1.063e-14
57 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 15 200 1.29e-16 1.063e-14
58 REGULATION OF TRANSFERASE ACTIVITY 25 946 1.368e-16 1.097e-14
59 ACTIVATION OF INNATE IMMUNE RESPONSE 15 204 1.737e-16 1.37e-14
60 REGULATION OF PROTEIN MODIFICATION PROCESS 31 1710 3.399e-16 2.636e-14
61 RESPONSE TO BACTERIUM 20 528 3.475e-16 2.65e-14
62 I KAPPAB KINASE NF KAPPAB SIGNALING 11 70 4.669e-16 3.504e-14
63 PHOSPHORYLATION 27 1228 5.489e-16 4.054e-14
64 ACTIVATION OF PROTEIN KINASE ACTIVITY 16 279 7.944e-16 5.776e-14
65 RESPONSE TO TUMOR NECROSIS FACTOR 15 233 1.27e-15 9.093e-14
66 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 12 109 1.722e-15 1.214e-13
67 RESPONSE TO EXTERNAL STIMULUS 31 1821 1.967e-15 1.366e-13
68 POSITIVE REGULATION OF PROTEOLYSIS 17 363 2.561e-15 1.753e-13
69 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 15 246 2.847e-15 1.92e-13
70 TOLL LIKE RECEPTOR SIGNALING PATHWAY 11 85 4.429e-15 2.944e-13
71 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 13 5.79e-15 3.795e-13
72 INFLAMMATORY RESPONSE 18 454 6.175e-15 3.991e-13
73 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 20 616 6.53e-15 4.162e-13
74 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 16 323 7.898e-15 4.966e-13
75 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 18 470 1.122e-14 6.962e-13
76 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 31 1977 1.903e-14 1.165e-12
77 REGULATION OF DEFENSE RESPONSE 21 759 2.774e-14 1.677e-12
78 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 8 28 3.034e-14 1.81e-12
79 REGULATION OF INNATE IMMUNE RESPONSE 16 357 3.74e-14 2.203e-12
80 FC EPSILON RECEPTOR SIGNALING PATHWAY 12 142 4.396e-14 2.557e-12
81 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 16 365 5.268e-14 2.99e-12
82 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 12 144 5.208e-14 2.99e-12
83 RESPONSE TO LIPID 22 888 5.496e-14 3.081e-12
84 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 17 6.493e-14 3.597e-12
85 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 9 50 6.833e-14 3.74e-12
86 REGULATION OF NEURON DEATH 14 252 9.569e-14 5.177e-12
87 INTRINSIC APOPTOTIC SIGNALING PATHWAY 12 152 1.001e-13 5.356e-12
88 CELLULAR RESPONSE TO MECHANICAL STIMULUS 10 80 1.209e-13 6.393e-12
89 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 8 33 1.337e-13 6.839e-12
90 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 8 33 1.337e-13 6.839e-12
91 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 33 1.337e-13 6.839e-12
92 CELLULAR RESPONSE TO ABIOTIC STIMULUS 14 263 1.72e-13 8.698e-12
93 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 34 1.744e-13 8.728e-12
94 CELLULAR RESPONSE TO STRESS 27 1565 2.034e-13 1.007e-11
95 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 12 171 4.125e-13 2.02e-11
96 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 22 5.62e-13 2.724e-11
97 RESPONSE TO HORMONE 21 893 6.482e-13 3.109e-11
98 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 22 1008 7.041e-13 3.343e-11
99 FC RECEPTOR SIGNALING PATHWAY 12 206 3.773e-12 1.773e-10
100 RESPONSE TO PEPTIDE 15 404 3.904e-12 1.816e-10
101 IMMUNE RESPONSE 22 1100 3.984e-12 1.836e-10
102 REGULATION OF CELL PROLIFERATION 25 1496 4.494e-12 2.05e-10
103 RESPONSE TO MECHANICAL STIMULUS 12 210 4.734e-12 2.139e-10
104 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 10 118 6.483e-12 2.901e-10
105 RESPONSE TO ORGANIC CYCLIC COMPOUND 20 917 1.03e-11 4.563e-10
106 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 55 1.107e-11 4.859e-10
107 POSITIVE REGULATION OF GENE EXPRESSION 26 1733 1.632e-11 7.096e-10
108 REGULATION OF CATABOLIC PROCESS 18 731 1.925e-11 8.292e-10
109 NEURON APOPTOTIC PROCESS 7 35 2.141e-11 9.141e-10
110 HOMEOSTATIC PROCESS 23 1337 2.416e-11 1.022e-09
111 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 15 465 2.864e-11 1.201e-09
112 WOUND HEALING 15 470 3.329e-11 1.383e-09
113 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 23 1360 3.407e-11 1.403e-09
114 RESPONSE TO WOUNDING 16 563 3.751e-11 1.531e-09
115 RESPONSE TO INORGANIC SUBSTANCE 15 479 4.346e-11 1.758e-09
116 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 11 195 4.554e-11 1.827e-09
117 T CELL RECEPTOR SIGNALING PATHWAY 10 146 5.473e-11 2.177e-09
118 CELLULAR RESPONSE TO EXTERNAL STIMULUS 12 264 6.865e-11 2.707e-09
119 POSITIVE REGULATION OF HYDROLASE ACTIVITY 19 905 7.33e-11 2.866e-09
120 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 8 71 9.275e-11 3.596e-09
121 CELLULAR RESPONSE TO PEPTIDE 12 274 1.055e-10 4.058e-09
122 RESPONSE TO AMINO ACID 9 112 1.274e-10 4.859e-09
123 NEGATIVE REGULATION OF CELL COMMUNICATION 21 1192 1.489e-10 5.633e-09
124 REGULATION OF HYDROLASE ACTIVITY 22 1327 1.529e-10 5.739e-09
125 RESPONSE TO INTERLEUKIN 1 9 115 1.618e-10 6.022e-09
126 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 7 46 1.656e-10 6.115e-09
127 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 13 360 1.773e-10 6.495e-09
128 PROTEOLYSIS 21 1208 1.903e-10 6.917e-09
129 NEURON DEATH 7 47 1.941e-10 7e-09
130 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 2.637e-10 9.437e-09
131 DEFENSE RESPONSE 21 1231 2.69e-10 9.554e-09
132 CELLULAR RESPONSE TO HORMONE STIMULUS 15 552 3.134e-10 1.096e-08
133 REGULATION OF CELLULAR PROTEIN LOCALIZATION 15 552 3.134e-10 1.096e-08
134 CHEMICAL HOMEOSTASIS 18 874 3.524e-10 1.224e-08
135 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 5 13 4.568e-10 1.574e-08
136 CELLULAR RESPONSE TO INTERLEUKIN 1 8 88 5.359e-10 1.833e-08
137 RESPONSE TO ACID CHEMICAL 12 319 6.037e-10 2.036e-08
138 REGULATION OF MAP KINASE ACTIVITY 12 319 6.037e-10 2.036e-08
139 EXECUTION PHASE OF APOPTOSIS 7 55 6.131e-10 2.052e-08
140 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 6 31 7.748e-10 2.575e-08
141 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 6 32 9.511e-10 3.117e-08
142 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 6 32 9.511e-10 3.117e-08
143 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 14 514 1.292e-09 4.203e-08
144 NEGATIVE REGULATION OF CATABOLIC PROCESS 10 203 1.394e-09 4.504e-08
145 NEGATIVE REGULATION OF MOLECULAR FUNCTION 19 1079 1.412e-09 4.53e-08
146 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 24 1805 1.554e-09 4.953e-08
147 RESPONSE TO OXIDATIVE STRESS 12 352 1.844e-09 5.836e-08
148 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 103 1.905e-09 5.991e-08
149 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 2.174e-09 6.788e-08
150 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 8 106 2.398e-09 7.438e-08
151 POSITIVE REGULATION OF NEURON DEATH 7 67 2.546e-09 7.845e-08
152 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 289 2.974e-09 9.104e-08
153 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 12 370 3.233e-09 9.831e-08
154 REGULATION OF MAPK CASCADE 15 660 3.604e-09 1.089e-07
155 CELLULAR RESPONSE TO BIOTIC STIMULUS 9 163 3.626e-09 1.089e-07
156 POSITIVE REGULATION OF MAPK CASCADE 13 470 4.517e-09 1.347e-07
157 RESPONSE TO CARBOHYDRATE 9 168 4.73e-09 1.402e-07
158 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 7 74 5.172e-09 1.523e-07
159 GLUCOSE HOMEOSTASIS 9 170 5.247e-09 1.526e-07
160 CARBOHYDRATE HOMEOSTASIS 9 170 5.247e-09 1.526e-07
161 CELLULAR GLUCOSE HOMEOSTASIS 7 75 5.69e-09 1.644e-07
162 RESPONSE TO OXYGEN LEVELS 11 311 6.384e-09 1.822e-07
163 HEMOSTASIS 11 311 6.384e-09 1.822e-07
164 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 6.44e-09 1.827e-07
165 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 121 6.877e-09 1.939e-07
166 INOSITOL LIPID MEDIATED SIGNALING 8 124 8.349e-09 2.34e-07
167 REGULATION OF PROTEIN LOCALIZATION 17 950 9.894e-09 2.757e-07
168 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 129 1.141e-08 3.16e-07
169 NIK NF KAPPAB SIGNALING 7 83 1.165e-08 3.209e-07
170 RESPONSE TO REACTIVE OXYGEN SPECIES 9 191 1.451e-08 3.972e-07
171 REGULATION OF NEURON APOPTOTIC PROCESS 9 192 1.519e-08 4.132e-07
172 REGULATION OF CELL ADHESION 14 629 1.686e-08 4.561e-07
173 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 51 1.799e-08 4.81e-07
174 RESPONSE TO NICOTINE 6 51 1.799e-08 4.81e-07
175 RESPONSE TO ALKALOID 8 137 1.832e-08 4.842e-07
176 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 1.828e-08 4.842e-07
177 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1004 2.235e-08 5.875e-07
178 REGULATION OF NECROTIC CELL DEATH 5 26 2.257e-08 5.901e-07
179 POSITIVE REGULATION OF MAP KINASE ACTIVITY 9 207 2.914e-08 7.574e-07
180 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 95 3.005e-08 7.769e-07
181 REGULATION OF LIPID METABOLIC PROCESS 10 282 3.235e-08 8.317e-07
182 PEPTIDYL SERINE MODIFICATION 8 148 3.353e-08 8.572e-07
183 CELLULAR RESPONSE TO LIPID 12 457 3.372e-08 8.574e-07
184 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 11 3.729e-08 9.429e-07
185 CELL ACTIVATION 13 568 4.247e-08 1.068e-06
186 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 9 218 4.552e-08 1.139e-06
187 REGULATION OF INFLAMMATORY RESPONSE 10 294 4.788e-08 1.191e-06
188 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 30 4.84e-08 1.198e-06
189 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 220 4.924e-08 1.208e-06
190 RENAL SYSTEM PROCESS 7 102 4.931e-08 1.208e-06
191 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 4 12 5.579e-08 1.345e-06
192 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 4 12 5.579e-08 1.345e-06
193 POSITIVE REGULATION OF TRANSPORT 16 936 5.536e-08 1.345e-06
194 POSITIVE REGULATION OF PROTEIN IMPORT 7 104 5.642e-08 1.353e-06
195 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 21 1672 6.215e-08 1.483e-06
196 REGULATION OF CELL ACTIVATION 12 484 6.315e-08 1.499e-06
197 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 32 6.805e-08 1.599e-06
198 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 5 32 6.805e-08 1.599e-06
199 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 17 1087 7.103e-08 1.661e-06
200 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 15 829 7.45e-08 1.733e-06
201 RESPONSE TO COBALT ION 4 13 8.038e-08 1.861e-06
202 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 8 168 8.976e-08 2.068e-06
203 T CELL HOMEOSTASIS 5 34 9.354e-08 2.103e-06
204 PROTEIN KINASE B SIGNALING 5 34 9.354e-08 2.103e-06
205 RENAL WATER HOMEOSTASIS 5 34 9.354e-08 2.103e-06
206 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 11 404 9.292e-08 2.103e-06
207 CELLULAR RESPONSE TO ALKALOID 5 34 9.354e-08 2.103e-06
208 RESPONSE TO TOXIC SUBSTANCE 9 241 1.074e-07 2.403e-06
209 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 4 14 1.123e-07 2.499e-06
210 REGULATION OF INTRACELLULAR TRANSPORT 13 621 1.197e-07 2.651e-06
211 RESPONSE TO CORTICOSTEROID 8 176 1.285e-07 2.834e-06
212 RESPONSE TO VIRUS 9 247 1.324e-07 2.906e-06
213 RESPONSE TO METAL ION 10 333 1.531e-07 3.328e-06
214 T CELL APOPTOTIC PROCESS 4 15 1.527e-07 3.328e-06
215 RESPONSE TO KETONE 8 182 1.663e-07 3.597e-06
216 CELLULAR RESPONSE TO GLUCAGON STIMULUS 5 38 1.67e-07 3.597e-06
217 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 7 122 1.697e-07 3.639e-06
218 REGULATION OF PROTEIN IMPORT 8 183 1.735e-07 3.687e-06
219 LEUKOCYTE CELL CELL ADHESION 9 255 1.736e-07 3.687e-06
220 RESPONSE TO DRUG 11 431 1.78e-07 3.765e-06
221 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 258 1.916e-07 4.035e-06
222 REGULATION OF ORGANELLE ORGANIZATION 17 1178 2.247e-07 4.709e-06
223 AGING 9 264 2.327e-07 4.856e-06
224 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 2.607e-07 5.415e-06
225 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 17 2.649e-07 5.478e-06
226 REGULATION OF NIK NF KAPPAB SIGNALING 5 42 2.801e-07 5.767e-06
227 MULTICELLULAR ORGANISMAL HOMEOSTASIS 9 272 2.994e-07 6.137e-06
228 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 5 43 3.161e-07 6.452e-06
229 LYMPHOCYTE APOPTOTIC PROCESS 4 18 3.397e-07 6.902e-06
230 POSITIVE REGULATION OF CELL PROLIFERATION 14 814 4.027e-07 8.146e-06
231 IMMUNE SYSTEM DEVELOPMENT 12 582 4.587e-07 9.239e-06
232 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 18 1395 4.787e-07 9.601e-06
233 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 88 4.913e-07 9.811e-06
234 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 47 4.986e-07 9.915e-06
235 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 5.139e-07 1.016e-05
236 REGULATION OF CELL CELL ADHESION 10 380 5.155e-07 1.016e-05
237 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 381 5.28e-07 1.037e-05
238 LEUKOCYTE DIFFERENTIATION 9 292 5.429e-07 1.061e-05
239 RESPONSE TO GLUCAGON 5 48 5.552e-07 1.081e-05
240 RESPONSE TO TEMPERATURE STIMULUS 7 148 6.322e-07 1.226e-05
241 NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS 4 21 6.594e-07 1.27e-05
242 CELL DEVELOPMENT 18 1426 6.604e-07 1.27e-05
243 LYMPHOCYTE HOMEOSTASIS 5 50 6.834e-07 1.309e-05
244 REGULATION OF CELLULAR LOCALIZATION 17 1277 6.991e-07 1.333e-05
245 REGULATION OF HOMOTYPIC CELL CELL ADHESION 9 307 8.243e-07 1.559e-05
246 REGULATION OF PROTEIN TARGETING 9 307 8.243e-07 1.559e-05
247 REGULATION OF LIPID CATABOLIC PROCESS 5 52 8.34e-07 1.571e-05
248 REGULATION OF BODY FLUID LEVELS 11 506 8.718e-07 1.636e-05
249 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 20 1784 8.78e-07 1.641e-05
250 LEUKOCYTE APOPTOTIC PROCESS 4 23 9.707e-07 1.807e-05
251 LIPID PHOSPHORYLATION 6 99 9.87e-07 1.83e-05
252 REGULATION OF GLUCOSE TRANSPORT 6 100 1.047e-06 1.926e-05
253 REGULATION OF TRANSPORT 20 1804 1.047e-06 1.926e-05
254 REGULATION OF RESPONSE TO WOUNDING 10 413 1.098e-06 2.003e-05
255 RESPONSE TO RADIATION 10 413 1.098e-06 2.003e-05
256 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 1.158e-06 2.104e-05
257 REGULATION OF EXECUTION PHASE OF APOPTOSIS 4 24 1.162e-06 2.104e-05
258 REGULATION OF CELL DIFFERENTIATION 18 1492 1.273e-06 2.296e-05
259 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 5 58 1.448e-06 2.601e-05
260 POSITIVE REGULATION OF CELL CELL ADHESION 8 243 1.488e-06 2.663e-05
261 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 1.578e-06 2.813e-05
262 NEGATIVE REGULATION OF NEURON DEATH 7 171 1.668e-06 2.963e-05
263 REGULATION OF GLUCOSE IMPORT 5 60 1.717e-06 3.026e-05
264 LEUKOCYTE HOMEOSTASIS 5 60 1.717e-06 3.026e-05
265 RESPONSE TO HYDROGEN PEROXIDE 6 109 1.738e-06 3.051e-05
266 REGULATION OF AUTOPHAGY 8 249 1.785e-06 3.123e-05
267 REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 4 27 1.905e-06 3.307e-05
268 DNA CATABOLIC PROCESS 4 27 1.905e-06 3.307e-05
269 LYMPHOCYTE ACTIVATION 9 342 2.011e-06 3.479e-05
270 CELLULAR HOMEOSTASIS 12 676 2.203e-06 3.796e-05
271 NECROTIC CELL DEATH 4 28 2.216e-06 3.806e-05
272 LEUKOCYTE MIGRATION 8 259 2.394e-06 4.095e-05
273 REGULATION OF CYTOKINE PRODUCTION 11 563 2.459e-06 4.19e-05
274 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 684 2.488e-06 4.225e-05
275 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 2.565e-06 4.308e-05
276 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 2.565e-06 4.308e-05
277 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 4 29 2.565e-06 4.308e-05
278 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 14 957 2.74e-06 4.586e-05
279 CELLULAR CHEMICAL HOMEOSTASIS 11 570 2.769e-06 4.618e-05
280 SINGLE ORGANISM CELL ADHESION 10 459 2.829e-06 4.702e-05
281 MYELOID CELL DIFFERENTIATION 7 189 3.245e-06 5.373e-05
282 WATER HOMEOSTASIS 5 70 3.707e-06 6.095e-05
283 REGULATION OF MEMBRANE PERMEABILITY 5 70 3.707e-06 6.095e-05
284 POSITIVE REGULATION OF CYTOKINE PRODUCTION 9 370 3.824e-06 6.266e-05
285 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 9 372 3.996e-06 6.523e-05
286 RESPONSE TO UV 6 126 4.042e-06 6.554e-05
287 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 126 4.042e-06 6.554e-05
288 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 12 720 4.214e-06 6.808e-05
289 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 4.285e-06 6.898e-05
290 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 8 282 4.49e-06 7.204e-05
291 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 15 1152 4.745e-06 7.588e-05
292 RESPONSE TO STEROID HORMONE 10 497 5.716e-06 9.109e-05
293 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 36 6.249e-06 9.924e-05
294 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 6.567e-06 0.0001036
295 ACTIVATION OF MAPK ACTIVITY 6 137 6.554e-06 0.0001036
296 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 5 80 7.176e-06 0.0001124
297 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 7.176e-06 0.0001124
298 REGULATION OF VITAMIN METABOLIC PROCESS 3 12 7.736e-06 0.0001204
299 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 12 7.736e-06 0.0001204
300 PLATELET ACTIVATION 6 142 8.053e-06 0.0001249
301 JNK CASCADE 5 82 8.103e-06 0.0001253
302 REGULATION OF MITOCHONDRION ORGANIZATION 7 218 8.29e-06 0.0001273
303 RESPONSE TO ESTROGEN 7 218 8.29e-06 0.0001273
304 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 8.384e-06 0.0001283
305 POSITIVE REGULATION OF CELL ACTIVATION 8 311 9.189e-06 0.0001402
306 LEUKOCYTE ACTIVATION 9 414 9.463e-06 0.0001434
307 RESPONSE TO ESTRADIOL 6 146 9.443e-06 0.0001434
308 HEPATOCYTE APOPTOTIC PROCESS 3 13 1.003e-05 0.0001511
309 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 3 13 1.003e-05 0.0001511
310 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 13 926 1.026e-05 0.0001539
311 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 88 1.146e-05 0.0001714
312 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 1.17e-05 0.0001744
313 RESPONSE TO HEAT 5 89 1.211e-05 0.00018
314 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 3 14 1.274e-05 0.0001888
315 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 43 1.286e-05 0.00019
316 CELL PROLIFERATION 11 672 1.317e-05 0.0001939
317 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 1.378e-05 0.0002023
318 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 44 1.411e-05 0.0002065
319 MITOCHONDRIAL MEMBRANE ORGANIZATION 5 92 1.423e-05 0.0002076
320 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 437 1.456e-05 0.0002117
321 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 5 94 1.58e-05 0.0002291
322 APOPTOTIC DNA FRAGMENTATION 3 15 1.589e-05 0.0002296
323 REGULATION OF LIPID TRANSPORT 5 95 1.664e-05 0.0002397
324 REGULATION OF CELLULAR RESPONSE TO STRESS 11 691 1.706e-05 0.0002451
325 RESPONSE TO ANTIBIOTIC 4 47 1.841e-05 0.0002635
326 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 10 573 1.967e-05 0.0002807
327 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 4 48 2.003e-05 0.000285
328 NEGATIVE REGULATION OF KINASE ACTIVITY 7 250 2.013e-05 0.0002856
329 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 7 252 2.119e-05 0.0002997
330 ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY 3 17 2.363e-05 0.0003301
331 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 17 2.363e-05 0.0003301
332 NEGATIVE REGULATION OF ANOIKIS 3 17 2.363e-05 0.0003301
333 RESPONSE TO GAMMA RADIATION 4 50 2.359e-05 0.0003301
334 GLYCEROLIPID METABOLIC PROCESS 8 356 2.434e-05 0.0003391
335 STRIATED MUSCLE CELL DIFFERENTIATION 6 173 2.476e-05 0.0003439
336 CELLULAR RESPONSE TO ACID CHEMICAL 6 175 2.642e-05 0.0003658
337 GAMETE GENERATION 10 595 2.714e-05 0.0003747
338 RESPONSE TO ALCOHOL 8 362 2.742e-05 0.0003775
339 RESPONSE TO GROWTH FACTOR 9 475 2.808e-05 0.0003855
340 NEGATIVE REGULATION OF ORGANIC ACID TRANSPORT 3 18 2.828e-05 0.000386
341 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 2.828e-05 0.000386
342 PHOSPHOLIPID METABOLIC PROCESS 8 364 2.852e-05 0.000388
343 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 4 53 2.977e-05 0.0004026
344 CELLULAR RESPONSE TO AMINO ACID STIMULUS 4 53 2.977e-05 0.0004026
345 CELL CELL ADHESION 10 608 3.261e-05 0.0004398
346 RESPONSE TO MUSCLE STRETCH 3 19 3.351e-05 0.0004477
347 NEGATIVE REGULATION OF MEIOTIC CELL CYCLE 3 19 3.351e-05 0.0004477
348 DNA CATABOLIC PROCESS ENDONUCLEOLYTIC 3 19 3.351e-05 0.0004477
349 IMMUNE EFFECTOR PROCESS 9 486 3.358e-05 0.0004477
350 POSITIVE REGULATION OF CELL ADHESION 8 376 3.591e-05 0.0004773
351 EMBRYO DEVELOPMENT 12 894 3.664e-05 0.0004857
352 INNATE IMMUNE RESPONSE 10 619 3.795e-05 0.0005016
353 SINGLE ORGANISM CELLULAR LOCALIZATION 12 898 3.827e-05 0.0005044
354 APOPTOTIC MITOCHONDRIAL CHANGES 4 57 3.975e-05 0.0005225
355 POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 58 4.259e-05 0.0005582
356 PROTEIN AUTOPHOSPHORYLATION 6 192 4.442e-05 0.0005805
357 MULTICELLULAR ORGANISM REPRODUCTION 11 768 4.495e-05 0.0005859
358 NECROPTOTIC PROCESS 3 21 4.577e-05 0.0005932
359 RESPONSE TO NITRIC OXIDE 3 21 4.577e-05 0.0005932
360 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 118 4.735e-05 0.000612
361 REGULATION OF MONOOXYGENASE ACTIVITY 4 60 4.87e-05 0.0006277
362 GLUCOSE METABOLIC PROCESS 5 119 4.93e-05 0.0006337
363 GLAND DEVELOPMENT 8 395 5.085e-05 0.0006518
364 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 8 397 5.268e-05 0.0006735
365 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 22 5.287e-05 0.000674
366 REGULATION OF B CELL ACTIVATION 5 121 5.339e-05 0.0006787
367 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 23 6.066e-05 0.000769
368 RESPONSE TO INSULIN 6 205 6.393e-05 0.0008083
369 REGULATION OF CELL CYCLE 12 949 6.526e-05 0.0008229
370 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 4 65 6.677e-05 0.0008397
371 REGULATION OF ANOIKIS 3 24 6.916e-05 0.0008673
372 REGULATION OF LIPID BIOSYNTHETIC PROCESS 5 128 6.978e-05 0.0008705
373 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 5 128 6.978e-05 0.0008705
374 POSITIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS 4 66 7.09e-05 0.0008821
375 LYMPHOCYTE DIFFERENTIATION 6 209 7.115e-05 0.0008828
376 NUCLEAR IMPORT 5 129 7.241e-05 0.000896
377 LIPID MODIFICATION 6 210 7.305e-05 0.0009016
378 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 9 541 7.683e-05 0.0009432
379 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 9 541 7.683e-05 0.0009432
380 CELLULAR EXTRAVASATION 3 25 7.84e-05 0.0009549
381 APOPTOTIC NUCLEAR CHANGES 3 25 7.84e-05 0.0009549
382 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 7.84e-05 0.0009549
383 NEGATIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 4 68 7.972e-05 0.0009685
384 B CELL ACTIVATION 5 132 8.075e-05 0.0009784
385 PROTEIN COMPLEX BIOGENESIS 13 1132 8.314e-05 0.001002
386 PROTEIN COMPLEX ASSEMBLY 13 1132 8.314e-05 0.001002
387 REGULATION OF HEMOPOIESIS 7 314 8.537e-05 0.001026
388 DEVELOPMENTAL PROGRAMMED CELL DEATH 3 26 8.841e-05 0.001058
389 NEGATIVE REGULATION OF LIPID TRANSPORT 3 26 8.841e-05 0.001058
390 POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION 4 70 8.93e-05 0.001065
391 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 13 1142 9.087e-05 0.001081
392 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 983 9.132e-05 0.001084
393 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 9 554 9.207e-05 0.00109
394 REGULATION OF FATTY ACID TRANSPORT 3 27 9.922e-05 0.001172
395 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 138 9.963e-05 0.001174
396 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 28 0.0001109 0.001299
397 MODULATION BY SYMBIONT OF HOST CELLULAR PROCESS 3 28 0.0001109 0.001299
398 NEGATIVE REGULATION OF PROTEOLYSIS 7 329 0.0001141 0.001334
399 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 4 75 0.0001169 0.00136
400 GRANULOCYTE MIGRATION 4 75 0.0001169 0.00136
401 PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 29 0.0001234 0.001424
402 MUSCLE ADAPTATION 3 29 0.0001234 0.001424
403 POSITIVE REGULATION OF MONOOXYGENASE ACTIVITY 3 29 0.0001234 0.001424
404 RESPONSE TO IONIZING RADIATION 5 145 0.0001258 0.001447
405 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 0.0001259 0.001447
406 REGULATION OF LEUKOCYTE DIFFERENTIATION 6 232 0.0001263 0.001447
407 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 6 233 0.0001293 0.001478
408 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 0.0001299 0.001481
409 LYMPHOCYTE COSTIMULATION 4 78 0.0001362 0.001549
410 NEGATIVE REGULATION OF B CELL ACTIVATION 3 30 0.0001367 0.001552
411 RESPONSE TO TRANSITION METAL NANOPARTICLE 5 148 0.0001385 0.001567
412 NEGATIVE REGULATION OF TRANSPORT 8 458 0.0001421 0.001601
413 MUSCLE CELL DIFFERENTIATION 6 237 0.0001418 0.001601
414 SEXUAL REPRODUCTION 10 730 0.0001491 0.001676
415 POSITIVE REGULATION OF INTERLEUKIN 2 PRODUCTION 3 31 0.000151 0.001693
416 MITOCHONDRION ORGANIZATION 9 594 0.0001559 0.001743
417 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 152 0.0001569 0.00175
418 REGULATION OF PROTEIN MATURATION 4 82 0.0001653 0.00184
419 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 7 351 0.0001701 0.001885
420 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 6 245 0.0001699 0.001885
421 PROTEIN IMPORT 5 155 0.0001719 0.001899
422 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 9 602 0.0001723 0.001899
423 RESPONSE TO FATTY ACID 4 83 0.0001732 0.001905
424 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 5 156 0.0001771 0.001939
425 PROTEIN LOCALIZATION TO NUCLEUS 5 156 0.0001771 0.001939
426 NEGATIVE REGULATION OF ANION TRANSPORT 3 33 0.0001824 0.001988
427 HEXOSE METABOLIC PROCESS 5 157 0.0001825 0.001988
428 REGULATION OF JNK CASCADE 5 159 0.0001935 0.002104
429 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0001987 0.002155
430 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 9 616 0.0002045 0.002213
431 CELLULAR LIPID METABOLIC PROCESS 11 913 0.0002083 0.002249
432 SYSTEM PROCESS 16 1785 0.0002105 0.002267
433 REGULATION OF PEPTIDE TRANSPORT 6 256 0.0002154 0.002315
434 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 4 89 0.0002267 0.002425
435 EPITHELIAL CELL PROLIFERATION 4 89 0.0002267 0.002425
436 REGULATION OF OXIDOREDUCTASE ACTIVITY 4 90 0.0002367 0.00252
437 CALCIUM MEDIATED SIGNALING 4 90 0.0002367 0.00252
438 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 5 167 0.0002431 0.002582
439 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 8 498 0.0002511 0.002662
440 MODULATION BY VIRUS OF HOST MORPHOLOGY OR PHYSIOLOGY 3 37 0.0002573 0.002721
441 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 3 39 0.0003012 0.003169
442 ERBB2 SIGNALING PATHWAY 3 39 0.0003012 0.003169
443 HOMEOSTASIS OF NUMBER OF CELLS 5 175 0.0003017 0.003169
444 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 0.0003031 0.003169
445 FEMALE GAMETE GENERATION 4 96 0.0003031 0.003169
446 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 10 801 0.0003146 0.003275
447 CELLULAR COMPONENT DISASSEMBLY 8 515 0.0003147 0.003275
448 MITOCHONDRIAL TRANSPORT 5 177 0.0003179 0.003296
449 REGULATION OF PROTEIN SECRETION 7 389 0.0003181 0.003296
450 REPRODUCTION 13 1297 0.00032 0.003309
451 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 0.0003249 0.003344
452 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0003249 0.003344
453 REGULATION OF PROTEIN CATABOLIC PROCESS 7 393 0.0003383 0.003475
454 MYELOID LEUKOCYTE MIGRATION 4 99 0.0003409 0.003494
455 INTERSPECIES INTERACTION BETWEEN ORGANISMS 9 662 0.0003477 0.003545
456 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 9 662 0.0003477 0.003545
457 RESPONSE TO LIGHT STIMULUS 6 280 0.0003482 0.003545
458 REGULATION OF LIPID STORAGE 3 41 0.0003497 0.003553
459 ESTABLISHMENT OF LOCALIZATION IN CELL 15 1676 0.0003525 0.003573
460 MUSCLE SYSTEM PROCESS 6 282 0.0003616 0.003658
461 REGULATION OF MYELOID CELL DIFFERENTIATION 5 183 0.0003706 0.00374
462 CELLULAR RESPONSE TO OXIDATIVE STRESS 5 184 0.0003799 0.003826
463 POSITIVE REGULATION OF CELL DIFFERENTIATION 10 823 0.0003899 0.003918
464 MYELOID LEUKOCYTE MEDIATED IMMUNITY 3 43 0.0004029 0.004032
465 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 3 43 0.0004029 0.004032
466 REGULATION OF INTERLEUKIN 6 PRODUCTION 4 104 0.0004112 0.004097
467 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 4 104 0.0004112 0.004097
468 LIPID BIOSYNTHETIC PROCESS 8 539 0.0004263 0.004229
469 TISSUE DEVELOPMENT 14 1518 0.0004259 0.004229
470 REGULATION OF CELL DEVELOPMENT 10 836 0.000441 0.004366
471 PROTEIN COMPLEX SUBUNIT ORGANIZATION 14 1527 0.0004521 0.004466
472 MODIFICATION BY SYMBIONT OF HOST MORPHOLOGY OR PHYSIOLOGY 3 45 0.0004611 0.004536
473 REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 45 0.0004611 0.004536
474 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 9 689 0.000465 0.004565
475 PEPTIDYL THREONINE MODIFICATION 3 46 0.0004921 0.00482
476 POSITIVE REGULATION OF LOCOMOTION 7 420 0.0005035 0.004922
477 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 197 0.0005188 0.00505
478 NEGATIVE REGULATION OF PHOSPHORYLATION 7 422 0.0005179 0.00505
479 POSITIVE REGULATION OF OXIDOREDUCTASE ACTIVITY 3 47 0.0005244 0.005094
480 REGULATION OF TYPE I INTERFERON PRODUCTION 4 111 0.0005263 0.005102
481 REGULATION OF CELL CYCLE PROCESS 8 558 0.0005359 0.005184
482 REGULATION OF LIPID KINASE ACTIVITY 3 48 0.000558 0.005353
483 REGULATION OF NF KAPPAB IMPORT INTO NUCLEUS 3 48 0.000558 0.005353
484 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 48 0.000558 0.005353
485 REGULATION OF INTERLEUKIN 2 PRODUCTION 3 48 0.000558 0.005353
486 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 4 113 0.000563 0.005379
487 PROTEIN HETEROOLIGOMERIZATION 4 113 0.000563 0.005379
488 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 4 114 0.000582 0.005538
489 MONOSACCHARIDE METABOLIC PROCESS 5 202 0.0005813 0.005538
490 PLASMA MEMBRANE ORGANIZATION 5 203 0.0005945 0.005594
491 REGULATION OF CERAMIDE BIOSYNTHETIC PROCESS 2 11 0.0005963 0.005594
492 POSITIVE REGULATION OF HAIR CYCLE 2 11 0.0005963 0.005594
493 REGULATION OF FEVER GENERATION 2 11 0.0005963 0.005594
494 REGULATION OF STEROID BIOSYNTHETIC PROCESS 3 49 0.0005929 0.005594
495 REGULATION OF NECROPTOTIC PROCESS 2 11 0.0005963 0.005594
496 BIOLOGICAL ADHESION 11 1032 0.0005903 0.005594
497 NEGATIVE REGULATION OF CELL CYCLE 7 433 0.0006033 0.005648
498 PROTEIN OLIGOMERIZATION 7 434 0.0006115 0.005714
499 REGULATION OF ORGANIC ACID TRANSPORT 3 50 0.0006293 0.005868
500 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 0.0006353 0.005912
501 MACROMOLECULAR COMPLEX ASSEMBLY 13 1398 0.0006542 0.006076
502 REGULATION OF INTERLEUKIN 12 PRODUCTION 3 51 0.000667 0.006183
503 RESPONSE TO EXTRACELLULAR STIMULUS 7 441 0.0006721 0.006217
504 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 5 209 0.0006781 0.006236
505 REGULATION OF PEPTIDE SECRETION 5 209 0.0006781 0.006236
506 GERM CELL DEVELOPMENT 5 209 0.0006781 0.006236
507 CYTOKINE PRODUCTION 4 120 0.0007058 0.006455
508 REGULATION OF T CELL MEDIATED IMMUNITY 3 52 0.0007062 0.006455
509 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 52 0.0007062 0.006455
510 POSITIVE REGULATION OF PROTEIN SECRETION 5 211 0.0007079 0.006459
511 REGULATION OF CHEMOKINE BIOSYNTHETIC PROCESS 2 12 0.000714 0.006464
512 I KAPPAB PHOSPHORYLATION 2 12 0.000714 0.006464
513 MYELIN MAINTENANCE 2 12 0.000714 0.006464
514 POSITIVE REGULATION OF INTERLEUKIN 2 BIOSYNTHETIC PROCESS 2 12 0.000714 0.006464
515 MULTI ORGANISM REPRODUCTIVE PROCESS 10 891 0.0007238 0.006539
516 REGULATION OF HOMEOSTATIC PROCESS 7 447 0.0007277 0.006562
517 NEGATIVE REGULATION OF AUTOPHAGY 3 53 0.0007468 0.006708
518 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 3 53 0.0007468 0.006708
519 REGULATION OF ADAPTIVE IMMUNE RESPONSE 4 123 0.0007742 0.006924
520 MEMBRANE ORGANIZATION 10 899 0.0007753 0.006924
521 T CELL DIFFERENTIATION 4 123 0.0007742 0.006924
522 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0007888 0.007004
523 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 5 216 0.0007866 0.007004
524 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 0.0007888 0.007004
525 REGULATION OF B CELL PROLIFERATION 3 55 0.0008323 0.007377
526 REGULATION OF SPHINGOLIPID BIOSYNTHETIC PROCESS 2 13 0.000842 0.007392
527 REGULATION OF MEMBRANE LIPID METABOLIC PROCESS 2 13 0.000842 0.007392
528 POSITIVE REGULATION OF STEROID BIOSYNTHETIC PROCESS 2 13 0.000842 0.007392
529 REGULATION OF HISTONE PHOSPHORYLATION 2 13 0.000842 0.007392
530 PROTEIN AUTOPROCESSING 2 13 0.000842 0.007392
531 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 750 0.000853 0.007475
532 NEGATIVE REGULATION OF ION TRANSPORT 4 127 0.0008725 0.007631
533 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 4 128 0.0008984 0.007843
534 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 3 57 0.0009239 0.00805
535 REGULATION OF DNA METABOLIC PROCESS 6 340 0.0009638 0.008383
536 MACROMOLECULE CATABOLIC PROCESS 10 926 0.000972 0.008438
537 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 4 131 0.0009793 0.008446
538 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0009802 0.008446
539 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0009802 0.008446
540 T CELL MIGRATION 2 14 0.0009802 0.008446
541 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.001073 0.009226
542 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 135 0.001095 0.009383
543 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 135 0.001095 0.009383
544 NEGATIVE REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 2 15 0.001129 0.009428
545 REGULATION OF HEAT GENERATION 2 15 0.001129 0.009428
546 RESPONSE TO MURAMYL DIPEPTIDE 2 15 0.001129 0.009428
547 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 0.001126 0.009428
548 NEGATIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 4 136 0.001125 0.009428
549 REGULATION OF HAIR FOLLICLE DEVELOPMENT 2 15 0.001129 0.009428
550 CELLULAR RESPONSE TO NITRIC OXIDE 2 15 0.001129 0.009428
551 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 3 61 0.001126 0.009428
552 RESPIRATORY BURST 2 15 0.001129 0.009428
553 NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION 2 15 0.001129 0.009428
554 NEGATIVE REGULATION OF B CELL PROLIFERATION 2 15 0.001129 0.009428
555 CHRONIC INFLAMMATORY RESPONSE 2 15 0.001129 0.009428
556 POSITIVE REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 2 15 0.001129 0.009428
557 NEUROTROPHIN TRK RECEPTOR SIGNALING PATHWAY 2 15 0.001129 0.009428
558 EPITHELIUM DEVELOPMENT 10 945 0.001134 0.009454
559 CELLULAR RESPONSE TO RADIATION 4 137 0.001156 0.009625
560 MAINTENANCE OF LOCATION 4 138 0.001188 0.00987
561 NEGATIVE REGULATION OF GENE EXPRESSION 13 1493 0.001203 0.009972
562 CARDIOVASCULAR SYSTEM DEVELOPMENT 9 788 0.001207 0.009972
563 CIRCULATORY SYSTEM DEVELOPMENT 9 788 0.001207 0.009972
NumGOOverlapSizeP ValueAdj. P Value
1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 10 47 4.143e-16 3.849e-13
2 CYTOKINE RECEPTOR BINDING 15 271 1.191e-14 5.533e-12
3 KINASE ACTIVITY 22 842 1.863e-14 5.77e-12
4 ENZYME BINDING 28 1737 3.224e-13 7.487e-11
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 22 992 5.114e-13 9.502e-11
6 PROTEIN SERINE THREONINE KINASE ACTIVITY 16 445 1.097e-12 1.699e-10
7 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 6 15 5.492e-12 7.289e-10
8 DEATH RECEPTOR BINDING 6 18 2.021e-11 2.347e-09
9 PROTEIN KINASE ACTIVITY 17 640 2.383e-11 2.459e-09
10 UBIQUITIN LIKE PROTEIN LIGASE BINDING 12 264 6.865e-11 6.378e-09
11 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 8.251e-11 6.969e-09
12 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 1.005e-10 7.779e-09
13 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 3.535e-10 2.526e-08
14 PROTEIN HETERODIMERIZATION ACTIVITY 14 468 3.835e-10 2.545e-08
15 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 8 86 4.447e-10 2.754e-08
16 TUMOR NECROSIS FACTOR RECEPTOR BINDING 6 30 6.265e-10 3.638e-08
17 KINASE BINDING 15 606 1.13e-09 6.175e-08
18 ADENYL NUCLEOTIDE BINDING 22 1514 1.85e-09 9.548e-08
19 IDENTICAL PROTEIN BINDING 18 1209 5.649e-08 2.762e-06
20 RIBONUCLEOTIDE BINDING 22 1860 7.891e-08 3.491e-06
21 ENZYME REGULATOR ACTIVITY 16 959 7.733e-08 3.491e-06
22 PROTEIN DIMERIZATION ACTIVITY 17 1149 1.575e-07 6.653e-06
23 CYSTEINE TYPE PEPTIDASE ACTIVITY 8 184 1.809e-07 7.256e-06
24 KINASE REGULATOR ACTIVITY 8 186 1.965e-07 7.256e-06
25 INTERLEUKIN 1 RECEPTOR BINDING 4 16 2.031e-07 7.256e-06
26 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 4 16 2.031e-07 7.256e-06
27 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 5 42 2.801e-07 9.638e-06
28 MOLECULAR FUNCTION REGULATOR 18 1353 3.051e-07 1.012e-05
29 PROTEIN DOMAIN SPECIFIC BINDING 12 624 9.567e-07 3.065e-05
30 RECEPTOR BINDING 18 1476 1.09e-06 3.374e-05
31 DEATH RECEPTOR ACTIVITY 4 24 1.162e-06 3.482e-05
32 PROTEASE BINDING 6 104 1.319e-06 3.83e-05
33 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 4 30 2.952e-06 8.31e-05
34 PROTEIN PHOSPHATASE BINDING 6 120 3.045e-06 8.321e-05
35 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 5.816e-06 0.0001544
36 PROTEIN KINASE A BINDING 4 42 1.17e-05 0.0003018
37 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 3 15 1.589e-05 0.0003989
38 PHOSPHATASE BINDING 6 162 1.708e-05 0.0004175
39 SIGNAL TRANSDUCER ACTIVITY 17 1731 4.057e-05 0.0009665
40 PEPTIDASE ACTIVATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 21 4.577e-05 0.001063
41 PROTEIN COMPLEX BINDING 12 935 5.657e-05 0.001282
42 CAMP BINDING 3 23 6.066e-05 0.001342
43 GROWTH FACTOR RECEPTOR BINDING 5 129 7.241e-05 0.001564
44 PEPTIDASE REGULATOR ACTIVITY 6 214 8.106e-05 0.001712
45 ENDOPEPTIDASE ACTIVITY 8 448 0.0001221 0.002521
46 PROTEIN HOMODIMERIZATION ACTIVITY 10 722 0.0001363 0.002753
47 HEAT SHOCK PROTEIN BINDING 4 89 0.0002267 0.004388
48 KINASE INHIBITOR ACTIVITY 4 89 0.0002267 0.004388
49 CYCLIC NUCLEOTIDE BINDING 3 36 0.000237 0.004494
50 ENZYME INHIBITOR ACTIVITY 7 378 0.0002674 0.004968
51 PEPTIDASE ACTIVATOR ACTIVITY 3 38 0.0002787 0.005077
52 SCAFFOLD PROTEIN BINDING 3 45 0.0004611 0.008237
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 15 237 1.637e-15 4.779e-13
2 MEMBRANE MICRODOMAIN 16 288 1.31e-15 4.779e-13
3 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 2.568e-13 4.999e-11
4 CATALYTIC COMPLEX 22 1038 1.263e-12 1.844e-10
5 MEMBRANE PROTEIN COMPLEX 20 1020 6.952e-11 8.12e-09
6 PROTEIN KINASE COMPLEX 8 90 6.428e-10 6.257e-08
7 TRANSFERASE COMPLEX 16 703 9.69e-10 8.084e-08
8 CILIARY BASE 5 23 1.164e-08 8.496e-07
9 MEMBRANE REGION 17 1134 1.306e-07 8.472e-06
10 CYTOSOLIC PART 8 223 7.807e-07 4.56e-05
11 PLASMA MEMBRANE PROTEIN COMPLEX 11 510 9.417e-07 4.999e-05
12 CD40 RECEPTOR COMPLEX 3 11 5.816e-06 0.0002613
13 IKAPPAB KINASE COMPLEX 3 11 5.816e-06 0.0002613
14 EXTRINSIC COMPONENT OF MEMBRANE 7 252 2.119e-05 0.0008839
15 RECEPTOR COMPLEX 7 327 0.0001099 0.004278
16 VACUOLE 13 1180 0.0001263 0.004608
17 PLASMA MEMBRANE RAFT 4 86 0.0001987 0.006825
18 MITOCHONDRION 15 1633 0.0002663 0.00864
19 PLASMA MEMBRANE RECEPTOR COMPLEX 5 175 0.0003017 0.009274

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 67 89 1.112e-173 1.968e-171
2 hsa04380_Osteoclast_differentiation 25 128 1.6e-38 1.416e-36
3 hsa04620_Toll.like_receptor_signaling_pathway 22 102 7.394e-35 4.362e-33
4 hsa04660_T_cell_receptor_signaling_pathway 22 108 2.97e-34 1.314e-32
5 hsa04662_B_cell_receptor_signaling_pathway 20 75 9.638e-34 3.412e-32
6 hsa04722_Neurotrophin_signaling_pathway 22 127 1.452e-32 4.285e-31
7 hsa04010_MAPK_signaling_pathway 26 268 9.781e-32 2.473e-30
8 hsa04370_VEGF_signaling_pathway 16 76 3.383e-25 7.485e-24
9 hsa04650_Natural_killer_cell_mediated_cytotoxicity 18 136 2.136e-24 4.2e-23
10 hsa04910_Insulin_signaling_pathway 18 138 2.814e-24 4.981e-23
11 hsa04062_Chemokine_signaling_pathway 19 189 2.209e-23 3.554e-22
12 hsa04920_Adipocytokine_signaling_pathway 13 68 5.289e-20 7.801e-19
13 hsa04914_Progesterone.mediated_oocyte_maturation 13 87 1.645e-18 2.239e-17
14 hsa04621_NOD.like_receptor_signaling_pathway 11 59 6.212e-17 7.854e-16
15 hsa04510_Focal_adhesion 15 200 1.29e-16 1.522e-15
16 hsa04973_Carbohydrate_digestion_and_absorption 10 44 2.001e-16 2.213e-15
17 hsa04622_RIG.I.like_receptor_signaling_pathway 11 71 5.511e-16 5.738e-15
18 hsa04150_mTOR_signaling_pathway 10 52 1.249e-15 1.229e-14
19 hsa04664_Fc_epsilon_RI_signaling_pathway 11 79 1.905e-15 1.775e-14
20 hsa04012_ErbB_signaling_pathway 11 87 5.784e-15 5.119e-14
21 hsa04630_Jak.STAT_signaling_pathway 12 155 1.268e-13 1.068e-12
22 hsa04666_Fc_gamma_R.mediated_phagocytosis 10 95 7.137e-13 5.742e-12
23 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 8.435e-11 6.491e-10
24 hsa04623_Cytosolic_DNA.sensing_pathway 7 56 6.989e-10 5.154e-09
25 hsa04115_p53_signaling_pathway 7 69 3.142e-09 2.224e-08
26 hsa04720_Long.term_potentiation 7 70 3.482e-09 2.37e-08
27 hsa04070_Phosphatidylinositol_signaling_system 7 78 7.514e-09 4.926e-08
28 hsa04114_Oocyte_meiosis 7 114 1.065e-07 6.729e-07
29 hsa04670_Leukocyte_transendothelial_migration 7 117 1.273e-07 7.77e-07
30 hsa04310_Wnt_signaling_pathway 7 151 7.239e-07 4.271e-06
31 hsa04020_Calcium_signaling_pathway 7 177 2.099e-06 1.199e-05
32 hsa04810_Regulation_of_actin_cytoskeleton 7 214 7.346e-06 4.063e-05
33 hsa00562_Inositol_phosphate_metabolism 4 57 3.975e-05 0.0002132
34 hsa04640_Hematopoietic_cell_lineage 4 88 0.0002171 0.00113
35 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.0004314 0.002181
36 hsa04742_Taste_transduction 3 52 0.0007062 0.003472
37 hsa04340_Hedgehog_signaling_pathway 3 56 0.0008773 0.004197
38 hsa04360_Axon_guidance 4 130 0.0009518 0.004433
39 hsa04976_Bile_secretion 3 71 0.001745 0.007921
40 hsa04971_Gastric_acid_secretion 3 74 0.001965 0.008697
41 hsa04141_Protein_processing_in_endoplasmic_reticulum 4 168 0.00244 0.01053
42 hsa04970_Salivary_secretion 3 89 0.003322 0.014
43 hsa04540_Gap_junction 3 90 0.003429 0.01411
44 hsa04912_GnRH_signaling_pathway 3 101 0.004739 0.01864
45 hsa04916_Melanogenesis 3 101 0.004739 0.01864
46 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.006955 0.02676
47 hsa04530_Tight_junction 3 133 0.0101 0.03805
48 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.07916 0.2919
49 hsa04740_Olfactory_transduction 3 388 0.141 0.5092

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-4O1.2 hsa-miR-155-5p;hsa-miR-23a-3p;hsa-miR-23b-3p;hsa-miR-27a-3p;hsa-miR-27b-3p;hsa-miR-33a-3p;hsa-miR-374b-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-708-3p 10 APAF1 Sponge network 0.371 0.46439 0.352 0.33131 0.476
2

MAGI2-AS3

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-142-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20b-5p;hsa-miR-3065-5p;hsa-miR-362-3p;hsa-miR-93-5p 11 AKT3 Sponge network -4.563 0 -3.327 1.0E-5 0.454
3

RP11-389C8.2

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-3065-5p;hsa-miR-429;hsa-miR-93-5p 18 PRKACB Sponge network -3.089 2.0E-5 -1.469 0.00691 0.394
4

MIR143HG

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-142-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20b-5p;hsa-miR-3065-5p;hsa-miR-93-5p 10 AKT3 Sponge network -6.51 0 -3.327 1.0E-5 0.394
5

RP11-284N8.3

hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-3065-5p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 13 PRKACB Sponge network -0.845 0.52848 -1.469 0.00691 0.371
6

RP11-389C8.2

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-192-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-3065-5p;hsa-miR-375;hsa-miR-429;hsa-miR-629-5p 16 BCL2 Sponge network -3.089 2.0E-5 -3.063 1.0E-5 0.366
7 RP11-296O14.3 hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p 12 PRKACB Sponge network -0.987 0.02492 -1.469 0.00691 0.362
8

RP11-819C21.1

hsa-miR-106b-5p;hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2355-3p;hsa-miR-25-3p;hsa-miR-27a-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-7-5p;hsa-miR-940 12 XIAP Sponge network -1.571 0.00379 0.212 0.49249 0.361
9

MAGI2-AS3

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-362-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 21 PRKACB Sponge network -4.563 0 -1.469 0.00691 0.359
10

AC003090.1

hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-320b;hsa-miR-320c;hsa-miR-330-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p 15 PIK3R1 Sponge network -7.817 0.00161 -1.854 0.01274 0.358
11

RP11-344E13.3

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20b-5p;hsa-miR-29b-2-5p;hsa-miR-29b-3p;hsa-miR-93-5p 10 AKT3 Sponge network -4.307 3.0E-5 -3.327 1.0E-5 0.355
12

DNM3OS

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-142-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20b-5p;hsa-miR-3065-5p;hsa-miR-502-3p;hsa-miR-93-5p 11 AKT3 Sponge network -3.933 0.00059 -3.327 1.0E-5 0.354
13

RP11-819C21.1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-629-5p;hsa-miR-7-5p 10 BCL2 Sponge network -1.571 0.00379 -3.063 1.0E-5 0.354
14

RP11-774O3.3

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-32-3p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-582-5p;hsa-miR-7-5p 16 BCL2 Sponge network -1.989 0.00136 -3.063 1.0E-5 0.35
15

HAND2-AS1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-32-3p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-629-5p;hsa-miR-7-5p 18 BCL2 Sponge network -7.871 0 -3.063 1.0E-5 0.35
16

ADAMTS9-AS1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-429;hsa-miR-451a;hsa-miR-582-5p;hsa-miR-590-5p;hsa-miR-629-5p;hsa-miR-7-5p 19 BCL2 Sponge network -8.573 0.00012 -3.063 1.0E-5 0.346
17

DNM3OS

hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 21 PRKACB Sponge network -3.933 0.00059 -1.469 0.00691 0.336
18 HOXB-AS2 hsa-miR-106b-5p;hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-17-5p;hsa-miR-181a-2-3p;hsa-miR-181b-5p;hsa-miR-20a-5p;hsa-miR-2355-3p;hsa-miR-27a-3p;hsa-miR-484 10 XIAP Sponge network -0.696 0.79824 0.212 0.49249 0.326
19

AC003090.1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-582-5p;hsa-miR-590-5p 14 BCL2 Sponge network -7.817 0.00161 -3.063 1.0E-5 0.326
20

HOXA11-AS

hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110 13 PRKACB Sponge network -3.349 0.00194 -1.469 0.00691 0.326
21

MIR497HG

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-590-5p;hsa-miR-7-5p 13 BCL2 Sponge network -6.146 0.00024 -3.063 1.0E-5 0.322
22

CBR3-AS1

hsa-miR-130a-5p;hsa-miR-17-5p;hsa-miR-181a-2-3p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-2355-3p;hsa-miR-27a-3p;hsa-miR-32-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-484;hsa-miR-589-3p;hsa-miR-766-3p;hsa-miR-940 18 XIAP Sponge network 0.742 0.15204 0.212 0.49249 0.314
23

RP11-401P9.4

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-142-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-20b-5p;hsa-miR-29b-3p;hsa-miR-502-3p;hsa-miR-93-5p 10 AKT3 Sponge network -3.793 0.00144 -3.327 1.0E-5 0.313
24 RAMP2-AS1 hsa-miR-192-5p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-32-3p;hsa-miR-338-5p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-629-5p 11 BCL2 Sponge network -2.152 0.07983 -3.063 1.0E-5 0.313
25

RP11-819C21.1

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-2110;hsa-miR-590-3p;hsa-miR-93-5p 11 PRKACB Sponge network -1.571 0.00379 -1.469 0.00691 0.31
26

ACTA2-AS1

hsa-miR-106b-5p;hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-17-5p;hsa-miR-181a-2-3p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-2355-3p;hsa-miR-25-3p;hsa-miR-27a-3p;hsa-miR-33a-3p;hsa-miR-484;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-5p;hsa-miR-940 19 XIAP Sponge network -6.142 0.00223 0.212 0.49249 0.308
27

MIR497HG

hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-320c;hsa-miR-584-5p;hsa-miR-590-5p;hsa-miR-629-3p 13 PIK3R1 Sponge network -6.146 0.00024 -1.854 0.01274 0.307
28 RP11-119F7.5 hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-192-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p 10 BCL2 Sponge network -2.406 0.03687 -3.063 1.0E-5 0.307
29

RP11-774O3.3

hsa-miR-1271-5p;hsa-miR-18a-3p;hsa-miR-222-5p;hsa-miR-29b-1-5p;hsa-miR-330-3p;hsa-miR-330-5p;hsa-miR-335-3p;hsa-miR-365a-3p;hsa-miR-582-5p;hsa-miR-590-3p 10 PIK3R3 Sponge network -1.989 0.00136 -0.03 0.95933 0.305
30

MIR143HG

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-192-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-3065-5p;hsa-miR-33b-5p;hsa-miR-429;hsa-miR-451a;hsa-miR-590-5p;hsa-miR-629-5p;hsa-miR-7-5p 20 BCL2 Sponge network -6.51 0 -3.063 1.0E-5 0.304
31

NR2F1-AS1

hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-629-5p;hsa-miR-7-5p 11 BCL2 Sponge network -2.961 0.00154 -3.063 1.0E-5 0.303
32

RP11-774O3.3

hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-320c;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-629-3p 16 PIK3R1 Sponge network -1.989 0.00136 -1.854 0.01274 0.303
33

LINC00865

hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-30d-3p;hsa-miR-429 14 PRKACB Sponge network -1.585 0.19508 -1.469 0.00691 0.302
34 CTC-296K1.3 hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-2110 11 PRKACB Sponge network -6.944 0.00011 -1.469 0.00691 0.302
35 EPB41L4A-AS1 hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-629-5p 10 BCL2 Sponge network -2.104 0 -3.063 1.0E-5 0.3
36

RP11-532F6.3

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-192-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-451a 13 BCL2 Sponge network -2.663 0.00676 -3.063 1.0E-5 0.299
37

ACTA2-AS1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-7-5p 14 BCL2 Sponge network -6.142 0.00223 -3.063 1.0E-5 0.298
38

RP11-389C8.2

hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-3065-5p;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-629-3p 11 PIK3R1 Sponge network -3.089 2.0E-5 -1.854 0.01274 0.297
39

MAGI2-AS3

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-188-5p;hsa-miR-205-5p;hsa-miR-20a-3p;hsa-miR-324-5p;hsa-miR-421;hsa-miR-429;hsa-miR-501-5p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-9-3p;hsa-miR-92a-3p;hsa-miR-944 14 IRAK3 Sponge network -4.563 0 -1.591 0.06089 0.295
40

RP11-532F6.3

hsa-let-7a-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-200c-3p 10 PRKACB Sponge network -2.663 0.00676 -1.469 0.00691 0.295
41

NDUFA6-AS1

hsa-miR-18a-3p;hsa-miR-222-5p;hsa-miR-29b-1-5p;hsa-miR-32-5p;hsa-miR-365a-3p;hsa-miR-511-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p 10 PIK3R3 Sponge network -1.026 0.04234 -0.03 0.95933 0.295
42

TRHDE-AS1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-32-3p;hsa-miR-33b-5p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-590-5p;hsa-miR-7-5p 17 BCL2 Sponge network -6.205 0.01165 -3.063 1.0E-5 0.295
43

FAM66C

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-2110;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 15 PRKACB Sponge network -2.927 0.00012 -1.469 0.00691 0.294
44 FAM225B hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-3065-5p;hsa-miR-590-3p;hsa-miR-93-5p 12 PRKACB Sponge network -2.388 0.00553 -1.469 0.00691 0.293
45

MAGI2-AS3

hsa-miR-141-3p;hsa-miR-155-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-25-3p;hsa-miR-30e-5p;hsa-miR-32-3p;hsa-miR-342-3p;hsa-miR-429;hsa-miR-590-3p 12 PRKAR1A Sponge network -4.563 0 -1.018 0.00123 0.292
46

NR2F1-AS1

hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-320b;hsa-miR-330-3p;hsa-miR-590-3p;hsa-miR-629-3p 12 PIK3R1 Sponge network -2.961 0.00154 -1.854 0.01274 0.292
47

PSMD5-AS1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-590-5p;hsa-miR-629-5p 10 BCL2 Sponge network -0.973 0.02357 -3.063 1.0E-5 0.286
48

RP11-567M16.1

hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-29b-3p;hsa-miR-320b;hsa-miR-330-3p;hsa-miR-335-3p;hsa-miR-590-5p;hsa-miR-629-3p 11 PIK3R1 Sponge network -2.638 0.21408 -1.854 0.01274 0.286
49

DNM3OS

hsa-miR-1301-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-3065-5p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-320c;hsa-miR-330-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p 15 PIK3R1 Sponge network -3.933 0.00059 -1.854 0.01274 0.285
50

FAM66C

hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-429;hsa-miR-590-5p;hsa-miR-7-5p 13 BCL2 Sponge network -2.927 0.00012 -3.063 1.0E-5 0.284
51

RP11-999E24.3

hsa-let-7f-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110 10 PRKACB Sponge network -4.893 2.0E-5 -1.469 0.00691 0.284
52

LINC00284

hsa-miR-18a-3p;hsa-miR-19b-3p;hsa-miR-222-5p;hsa-miR-29b-1-5p;hsa-miR-330-3p;hsa-miR-330-5p;hsa-miR-365a-3p;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-590-5p 10 PIK3R3 Sponge network -5.478 0.02716 -0.03 0.95933 0.283
53 RP11-83A24.2 hsa-miR-130a-5p;hsa-miR-17-5p;hsa-miR-181a-2-3p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-2355-3p;hsa-miR-27a-3p;hsa-miR-335-3p;hsa-miR-484 11 XIAP Sponge network -0.473 0.33893 0.212 0.49249 0.282
54

RP11-166D19.1

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-30d-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-96-5p 19 PRKACB Sponge network -4.209 2.0E-5 -1.469 0.00691 0.282
55

RP11-774O3.3

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-590-3p 12 PRKACB Sponge network -1.989 0.00136 -1.469 0.00691 0.28
56

AC003090.1

hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 16 PRKACB Sponge network -7.817 0.00161 -1.469 0.00691 0.279
57

NR2F1-AS1

hsa-miR-18a-3p;hsa-miR-19b-3p;hsa-miR-222-5p;hsa-miR-29b-1-5p;hsa-miR-32-5p;hsa-miR-330-3p;hsa-miR-330-5p;hsa-miR-365a-3p;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-92a-3p 11 PIK3R3 Sponge network -2.961 0.00154 -0.03 0.95933 0.279
58

MAGI2-AS3

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-3065-5p;hsa-miR-32-3p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-429;hsa-miR-629-5p;hsa-miR-7-5p 18 BCL2 Sponge network -4.563 0 -3.063 1.0E-5 0.277
59

ZNF667-AS1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-590-5p;hsa-miR-629-5p;hsa-miR-7-5p 12 BCL2 Sponge network -4.019 0.00137 -3.063 1.0E-5 0.273
60

ZNF667-AS1

hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-320c;hsa-miR-590-5p;hsa-miR-629-3p 11 PIK3R1 Sponge network -4.019 0.00137 -1.854 0.01274 0.273
61

RP11-166D19.1

hsa-miR-141-3p;hsa-miR-155-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-25-3p;hsa-miR-32-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-96-5p 12 PRKAR1A Sponge network -4.209 2.0E-5 -1.018 0.00123 0.272
62

HAND2-AS1

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 18 PRKACB Sponge network -7.871 0 -1.469 0.00691 0.272
63 PWAR6 hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200b-5p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-629-5p 10 BCL2 Sponge network -3.15 0.0082 -3.063 1.0E-5 0.271
64

AGAP11

hsa-miR-106a-5p;hsa-miR-107;hsa-miR-130b-3p;hsa-miR-192-5p;hsa-miR-20b-5p;hsa-miR-215-5p;hsa-miR-301a-3p;hsa-miR-335-3p;hsa-miR-375;hsa-miR-93-5p 10 IL1RAP Sponge network -2.702 0.0073 1.813 0.02672 0.268
65

DNM3OS

hsa-miR-141-3p;hsa-miR-155-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-25-3p;hsa-miR-32-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-96-5p 12 PRKAR1A Sponge network -3.933 0.00059 -1.018 0.00123 0.264
66

ACTA2-AS1

hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-590-3p 10 PIK3R1 Sponge network -6.142 0.00223 -1.854 0.01274 0.264
67 OR2A1-AS1 hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-17-5p;hsa-miR-181a-2-3p;hsa-miR-181b-5p;hsa-miR-2355-3p;hsa-miR-27a-3p;hsa-miR-320b;hsa-miR-484;hsa-miR-589-3p;hsa-miR-7-5p;hsa-miR-766-3p;hsa-miR-940 13 XIAP Sponge network -0.252 0.68973 0.212 0.49249 0.263
68

C1RL-AS1

hsa-miR-148b-5p;hsa-miR-188-5p;hsa-miR-20a-3p;hsa-miR-3200-3p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-501-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-660-5p;hsa-miR-708-3p;hsa-miR-9-3p 12 IRAK3 Sponge network -0.784 0.21481 -1.591 0.06089 0.261
69

RP11-999E24.3

hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-215-5p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-7-5p 11 BCL2 Sponge network -4.893 2.0E-5 -3.063 1.0E-5 0.258
70

TPTEP1

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-24-2-5p;hsa-miR-33b-5p;hsa-miR-365a-3p;hsa-miR-7-5p 12 BCL2 Sponge network -4.398 5.0E-5 -3.063 1.0E-5 0.257
71

MIR143HG

hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-2110;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 20 PRKACB Sponge network -6.51 0 -1.469 0.00691 0.253
72 RP11-400K9.4 hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-93-5p 11 PRKACB Sponge network -0.419 0.72905 -1.469 0.00691 0.253
73

WT1-AS

hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-200c-3p;hsa-miR-20a-3p;hsa-miR-24-2-5p;hsa-miR-32-3p;hsa-miR-429;hsa-miR-629-5p 13 BCL2 Sponge network -6.875 2.0E-5 -3.063 1.0E-5 0.253

Quest ID: e70a3639b5a4686c379c91a7988f1ebf