Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7d-5p APP 1.33 0 -0.4 0.04288 miRNAWalker2 validate -0.31 0 NA
2 hsa-let-7g-3p APP 3.26 0 -0.4 0.04288 miRNATAP -0.19 0 NA
3 hsa-miR-101-3p APP 0.52 0.00376 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0 NA
4 hsa-miR-106a-5p APP 2.49 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.14 0 NA
5 hsa-miR-106b-5p APP 2.47 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.26 0 NA
6 hsa-miR-15a-5p APP 2.35 0 -0.4 0.04288 miRNAWalker2 validate; miRNATAP -0.22 0 NA
7 hsa-miR-15b-5p APP 1.57 0 -0.4 0.04288 miRNATAP -0.19 1.0E-5 NA
8 hsa-miR-16-5p APP 1.76 0 -0.4 0.04288 miRNAWalker2 validate; miRNATAP -0.18 4.0E-5 NA
9 hsa-miR-17-5p APP 3.27 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.16 0 NA
10 hsa-miR-185-5p APP 2.34 0 -0.4 0.04288 miRNATAP -0.26 0 NA
11 hsa-miR-20a-5p APP 3.16 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.18 0 20458444 miR 20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells; Furthermore suppression of APP expression could also promote ovarian cancer cell proliferation and invasion which is consistent with the results of miR-20a overexpression; Therefore we concluded that the regulation of APP is an important mechanism for miR-20a to promote proliferation and invasion in ovarian cancer cells
12 hsa-miR-324-5p APP 2.96 0 -0.4 0.04288 PITA; miRanda; miRNATAP -0.14 0 NA
13 hsa-miR-328-3p APP 0.6 0.01386 -0.4 0.04288 miRNAWalker2 validate -0.14 0.00029 NA
14 hsa-miR-361-3p APP 1.07 0 -0.4 0.04288 miRNATAP -0.21 8.0E-5 NA
15 hsa-miR-423-3p APP 2.58 0 -0.4 0.04288 miRNAWalker2 validate -0.22 0 NA
16 hsa-miR-429 APP 4.49 0 -0.4 0.04288 miRanda -0.12 0 NA
17 hsa-miR-484 APP 1.82 0 -0.4 0.04288 miRNAWalker2 validate -0.19 0 NA
18 hsa-miR-532-3p APP 1.97 0 -0.4 0.04288 miRNAWalker2 validate; PITA -0.15 1.0E-5 NA
19 hsa-miR-582-5p APP 0.61 0.03299 -0.4 0.04288 miRNATAP -0.13 6.0E-5 NA
20 hsa-miR-590-3p APP 2.59 0 -0.4 0.04288 miRanda -0.17 0 NA
21 hsa-miR-660-5p APP 1.83 0 -0.4 0.04288 MirTarget -0.17 0 NA
22 hsa-miR-93-5p APP 3.04 0 -0.4 0.04288 miRNATAP -0.22 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DEATH 33 1472 3.804e-10 5.9e-07
2 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 27 983 2.664e-10 5.9e-07
3 REGULATION OF PHOSPHORUS METABOLIC PROCESS 35 1618 2.538e-10 5.9e-07
4 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 32 1492 2.243e-09 2.609e-06
5 REGULATION OF PROTEIN MODIFICATION PROCESS 34 1710 4.341e-09 4.04e-06
6 RESPONSE TO ORGANIC CYCLIC COMPOUND 24 917 7.832e-09 4.556e-06
7 RESPONSE TO OXYGEN CONTAINING COMPOUND 30 1381 5.979e-09 4.556e-06
8 CELLULAR RESPONSE TO STRESS 32 1565 7.162e-09 4.556e-06
9 NEGATIVE REGULATION OF GENE EXPRESSION 31 1493 9.124e-09 4.717e-06
10 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 30 1517 4.998e-08 2.114e-05
11 RESPONSE TO LIGHT STIMULUS 13 280 4.804e-08 2.114e-05
12 RESPONSE TO ABIOTIC STIMULUS 24 1024 6.384e-08 2.476e-05
13 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 876 7.411e-08 2.652e-05
14 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 33 1848 1.041e-07 3.459e-05
15 REGULATION OF CELL DIFFERENTIATION 29 1492 1.272e-07 3.945e-05
16 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 34 1977 1.557e-07 4.528e-05
17 POSITIVE REGULATION OF MOLECULAR FUNCTION 32 1791 1.693e-07 4.608e-05
18 RESPONSE TO DRUG 15 431 1.882e-07 4.608e-05
19 CELL DEVELOPMENT 28 1426 1.785e-07 4.608e-05
20 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 23 1036 3.272e-07 6.362e-05
21 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 30 1656 3.38e-07 6.362e-05
22 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 20 799 3.286e-07 6.362e-05
23 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 23 1036 3.272e-07 6.362e-05
24 REGULATION OF RESPONSE TO STRESS 28 1468 3.232e-07 6.362e-05
25 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 20 801 3.418e-07 6.362e-05
26 REPRODUCTION 26 1297 3.599e-07 6.442e-05
27 RESPONSE TO KETONE 10 182 3.903e-07 6.726e-05
28 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 30 1672 4.15e-07 6.781e-05
29 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 24 1135 4.226e-07 6.781e-05
30 REGULATION OF CELL PROLIFERATION 28 1496 4.739e-07 7.349e-05
31 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 15 465 4.947e-07 7.426e-05
32 POSITIVE REGULATION OF CELL DEATH 17 605 5.649e-07 8.214e-05
33 RESPONSE TO ENDOGENOUS STIMULUS 27 1450 8.754e-07 0.0001234
34 REGULATION OF KINASE ACTIVITY 19 776 9.297e-07 0.0001272
35 RESPONSE TO NITROGEN COMPOUND 20 859 1.02e-06 0.0001356
36 REGULATION OF TRANSFERASE ACTIVITY 21 946 1.142e-06 0.0001475
37 CHEMICAL HOMEOSTASIS 20 874 1.331e-06 0.0001639
38 RESPONSE TO FATTY ACID 7 83 1.338e-06 0.0001639
39 REGULATION OF PROTEIN BINDING 9 168 1.876e-06 0.0002238
40 GLUCOSE HOMEOSTASIS 9 170 2.069e-06 0.0002348
41 CARBOHYDRATE HOMEOSTASIS 9 170 2.069e-06 0.0002348
42 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 5 33 2.464e-06 0.000273
43 POSITIVE REGULATION OF GENE EXPRESSION 29 1733 2.771e-06 0.0002846
44 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 22 1087 2.814e-06 0.0002846
45 ACTIVATION OF PROTEIN KINASE ACTIVITY 11 279 2.68e-06 0.0002846
46 REGULATION OF CELL DEVELOPMENT 19 836 2.785e-06 0.0002846
47 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 10 228 3.023e-06 0.0002931
48 NEGATIVE REGULATION OF CELL DIFFERENTIATION 16 609 2.971e-06 0.0002931
49 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 14 470 3.086e-06 0.0002931
50 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 289 3.759e-06 0.0003498
51 RESPONSE TO RADIATION 13 413 3.904e-06 0.0003561
52 POSITIVE REGULATION OF KINASE ACTIVITY 14 482 4.126e-06 0.0003623
53 SMALL MOLECULE METABOLIC PROCESS 29 1767 4.068e-06 0.0003623
54 SYNAPTIC SIGNALING 13 424 5.19e-06 0.0004472
55 ORGANONITROGEN COMPOUND METABOLIC PROCESS 29 1796 5.593e-06 0.0004732
56 PHOSPHORYLATION 23 1228 5.897e-06 0.00049
57 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 12 365 6.034e-06 0.0004926
58 PROTEIN LOCALIZATION 29 1805 6.164e-06 0.0004945
59 CELLULAR RESPONSE TO NITROGEN COMPOUND 14 505 7.026e-06 0.0005541
60 REGULATION OF CATABOLIC PROCESS 17 731 7.241e-06 0.0005615
61 HOMEOSTATIC PROCESS 24 1337 7.368e-06 0.000562
62 POSITIVE REGULATION OF CELL COMMUNICATION 26 1532 7.872e-06 0.0005908
63 REGULATION OF MAPK CASCADE 16 660 8.21e-06 0.0006063
64 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 740 8.497e-06 0.0006177
65 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 17 750 1.012e-05 0.0007243
66 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 15 602 1.163e-05 0.0008196
67 MULTI MULTICELLULAR ORGANISM PROCESS 9 213 1.294e-05 0.000899
68 GUANOSINE CONTAINING COMPOUND METABOLIC PROCESS 5 46 1.328e-05 0.0009088
69 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 24 1395 1.495e-05 0.001008
70 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 15 616 1.523e-05 0.001013
71 POSITIVE REGULATION OF MAPK CASCADE 13 470 1.557e-05 0.001015
72 PROTEIN PHOSPHORYLATION 19 944 1.57e-05 0.001015
73 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 8 168 1.687e-05 0.001075
74 REGULATION OF NEURON PROJECTION DEVELOPMENT 12 408 1.839e-05 0.001156
75 NEGATIVE REGULATION OF CELL DEATH 18 872 1.923e-05 0.001193
76 POSITIVE REGULATION OF CATALYTIC ACTIVITY 25 1518 2.023e-05 0.001223
77 REGULATION OF BINDING 10 283 2.006e-05 0.001223
78 RESPONSE TO EXTERNAL STIMULUS 28 1821 2.082e-05 0.001242
79 REGULATION OF EPITHELIAL CELL PROLIFERATION 10 285 2.131e-05 0.001255
80 CELLULAR RESPONSE TO FATTY ACID 5 51 2.216e-05 0.001289
81 RESPONSE TO LIPID 18 888 2.446e-05 0.001405
82 NEGATIVE REGULATION OF CELL PROLIFERATION 15 643 2.509e-05 0.001424
83 MULTI ORGANISM REPRODUCTIVE PROCESS 18 891 2.558e-05 0.001434
84 MOTOR NEURON AXON GUIDANCE 4 27 2.913e-05 0.001614
85 NEGATIVE REGULATION OF MOLECULAR FUNCTION 20 1079 3e-05 0.001641
86 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 23 1360 3.033e-05 0.001641
87 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 3.381e-05 0.001808
88 INTERSPECIES INTERACTION BETWEEN ORGANISMS 15 662 3.507e-05 0.001833
89 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 15 662 3.507e-05 0.001833
90 NEGATIVE REGULATION OF CELL DEVELOPMENT 10 303 3.589e-05 0.001835
91 INTRACELLULAR SIGNAL TRANSDUCTION 25 1572 3.624e-05 0.001835
92 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 17 829 3.629e-05 0.001835
93 MULTI ORGANISM METABOLIC PROCESS 7 138 3.859e-05 0.001912
94 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 19 1008 3.863e-05 0.001912
95 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 95 4.134e-05 0.002025
96 PEPTIDYL AMINO ACID MODIFICATION 17 841 4.342e-05 0.002104
97 REGULATION OF NEURON APOPTOTIC PROCESS 8 192 4.391e-05 0.002106
98 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 30 4.479e-05 0.002127
99 PROTEIN HOMOTETRAMERIZATION 5 59 4.526e-05 0.002127
100 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 27 1805 4.876e-05 0.002246
101 REGULATION OF NEURON DEATH 9 252 4.858e-05 0.002246
102 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 7 144 5.062e-05 0.002287
103 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 7 144 5.062e-05 0.002287
104 CELL CELL SIGNALING 16 767 5.113e-05 0.002288
105 SINGLE ORGANISM BEHAVIOR 11 384 5.275e-05 0.002316
106 RESPIRATORY SYSTEM DEVELOPMENT 8 197 5.266e-05 0.002316
107 POSITIVE REGULATION OF RESPONSE TO STIMULUS 28 1929 5.849e-05 0.00252
108 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 10 321 5.828e-05 0.00252
109 NUCLEOBASE CONTAINING SMALL MOLECULE METABOLIC PROCESS 13 535 5.942e-05 0.002536
110 ESTABLISHMENT OF PROTEIN LOCALIZATION 23 1423 6.108e-05 0.002561
111 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 3 12 6.054e-05 0.002561
112 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 262 6.559e-05 0.002677
113 REGULATION OF PROTEIN CATABOLIC PROCESS 11 393 6.493e-05 0.002677
114 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 103 6.512e-05 0.002677
115 POSITIVE REGULATION OF MAP KINASE ACTIVITY 8 207 7.456e-05 0.003017
116 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 106 7.644e-05 0.003066
117 REGULATION OF PROTEOLYSIS 15 711 7.858e-05 0.003125
118 ORGANOPHOSPHATE METABOLIC PROCESS 17 885 8.137e-05 0.003186
119 TUBE DEVELOPMENT 13 552 8.147e-05 0.003186
120 POSITIVE REGULATION OF NEURON DEATH 5 67 8.368e-05 0.003218
121 RESPONSE TO MONOAMINE 4 35 8.34e-05 0.003218
122 REGULATION OF NEURON DIFFERENTIATION 13 554 8.448e-05 0.003222
123 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 337 8.726e-05 0.003274
124 RESPONSE TO INORGANIC SUBSTANCE 12 479 8.67e-05 0.003274
125 REGULATION OF CELL PROJECTION ORGANIZATION 13 558 9.079e-05 0.003353
126 RESPONSE TO HORMONE 17 893 9.078e-05 0.003353
127 REGULATION OF OSTEOBLAST DIFFERENTIATION 6 112 0.0001038 0.003802
128 NOTCH SIGNALING PATHWAY 6 114 0.0001144 0.00416
129 RESPONSE TO TESTOSTERONE 4 38 0.0001158 0.004176
130 NEGATIVE REGULATION OF CELL COMMUNICATION 20 1192 0.0001189 0.004256
131 NEGATIVE REGULATION OF TELOMERASE ACTIVITY 3 15 0.0001234 0.004284
132 ECTODERMAL PLACODE DEVELOPMENT 3 15 0.0001234 0.004284
133 ECTODERMAL PLACODE MORPHOGENESIS 3 15 0.0001234 0.004284
134 ECTODERMAL PLACODE FORMATION 3 15 0.0001234 0.004284
135 CELLULAR RESPONSE TO KETONE 5 73 0.0001261 0.004345
136 ERBB2 SIGNALING PATHWAY 4 39 0.0001283 0.004391
137 REGULATION OF AXONOGENESIS 7 168 0.0001334 0.00453
138 NEUROGENESIS 22 1402 0.0001386 0.004672
139 SECRETION 13 588 0.0001526 0.005036
140 GUANOSINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 3 16 0.0001511 0.005036
141 ORGANONITROGEN COMPOUND BIOSYNTHETIC PROCESS 18 1024 0.0001518 0.005036
142 REGULATION OF DEFENSE RESPONSE 15 759 0.0001613 0.005287
143 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 6 123 0.0001737 0.005651
144 SYNAPTIC TRANSMISSION DOPAMINERGIC 3 17 0.0001826 0.005883
145 MULTICELLULAR ORGANISM REPRODUCTION 15 768 0.0001833 0.005883
146 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 684 0.0001884 0.006004
147 RESPONSE TO UV 6 126 0.0001981 0.006269
148 REGULATION OF CELLULAR RESPONSE TO STRESS 14 691 0.0002092 0.006576
149 PROTEIN LOCALIZATION TO MEMBRANE 10 376 0.0002127 0.006643
150 RESPONSE TO BACTERIUM 12 528 0.0002146 0.006658
151 JNK CASCADE 5 82 0.0002183 0.006728
152 REGULATION OF ERBB SIGNALING PATHWAY 5 83 0.0002311 0.007075
153 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 616 0.0002402 0.007304
154 CELLULAR RESPONSE TO LIPID 11 457 0.0002432 0.007349
155 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 6 132 0.0002549 0.007651
156 TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 85 0.0002583 0.007706
157 ESTABLISHMENT OF LOCALIZATION IN CELL 24 1676 0.0002661 0.007866
158 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 47 0.0002671 0.007866
159 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 25 1784 0.0002706 0.00792
160 NEURON PROJECTION DEVELOPMENT 12 545 0.0002865 0.00822
161 HEART DEVELOPMENT 11 466 0.0002873 0.00822
162 REGULATION OF MAP KINASE ACTIVITY 9 319 0.000288 0.00822
163 PROTEIN TETRAMERIZATION 6 135 0.0002877 0.00822
164 REGULATION OF CELLULAR LOCALIZATION 20 1277 0.000296 0.008364
165 REGULATION OF PEPTIDASE ACTIVITY 10 392 0.0002966 0.008364
166 PROTEIN AUTOPHOSPHORYLATION 7 192 0.0003026 0.008482
167 REGULATION OF GROWTH 13 633 0.000312 0.008524
168 RESPONSE TO ALKALOID 6 137 0.0003114 0.008524
169 PURINE NUCLEOSIDE BIOSYNTHETIC PROCESS 5 89 0.0003201 0.008524
170 REGULATION OF TRANSPORT 25 1804 0.0003206 0.008524
171 PURINE CONTAINING COMPOUND METABOLIC PROCESS 10 394 0.0003088 0.008524
172 GLAND DEVELOPMENT 10 395 0.000315 0.008524
173 ACTIVATION OF MAPK ACTIVITY 6 137 0.0003114 0.008524
174 PURINE RIBONUCLEOSIDE BIOSYNTHETIC PROCESS 5 89 0.0003201 0.008524
175 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 14 720 0.0003176 0.008524
176 PURINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 6 139 0.0003366 0.008899
177 CELL DEATH 17 1001 0.0003503 0.009209
178 NEGATIVE REGULATION OF PROTEOLYSIS 9 329 0.0003609 0.009433
179 RESPONSE TO AMMONIUM ION 4 51 0.0003666 0.00953
180 POSITIVE REGULATION OF CELL DIFFERENTIATION 15 823 0.0003832 0.009906
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR BINDING 28 1476 3.609e-07 0.0003353
2 ENZYME BINDING 30 1737 9.281e-07 0.0004311
3 TRANSCRIPTION FACTOR BINDING 15 524 2.188e-06 0.0006777
4 KINASE ACTIVITY 18 842 1.203e-05 0.002795
5 IDENTICAL PROTEIN BINDING 22 1209 1.519e-05 0.002822
6 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 19 992 3.109e-05 0.004814
7 KINASE BINDING 14 606 5.271e-05 0.006512
8 ADENYL NUCLEOTIDE BINDING 24 1514 5.608e-05 0.006512
9 BETA AMYLOID BINDING 4 35 8.34e-05 0.008609
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 23 942 5.994e-08 3.501e-05
2 NEURON PART 25 1265 8.175e-07 0.0002387
3 AXON 13 418 4.448e-06 0.000866
4 SOMATODENDRITIC COMPARTMENT 16 650 6.782e-06 0.0009902
5 CELL PROJECTION 28 1786 1.458e-05 0.001703
6 PERINUCLEAR REGION OF CYTOPLASM 15 642 2.464e-05 0.001914
7 CELL BODY 13 494 2.621e-05 0.001914
8 CELL LEADING EDGE 11 350 2.27e-05 0.001914
9 CELL PROJECTION PART 18 946 5.58e-05 0.003193
10 MEMBRANE REGION 20 1134 6.015e-05 0.003193
11 SYNAPSE PART 14 610 5.657e-05 0.003193
12 MITOCHONDRION 25 1633 6.748e-05 0.003284
13 PERIKARYON 6 108 8.482e-05 0.00381
14 CYTOPLASMIC SIDE OF MEMBRANE 7 170 0.0001435 0.005988
15 POSTSYNAPSE 10 378 0.000222 0.008102
16 DENDRITE 11 451 0.0002172 0.008102

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03010_Ribosome 5 92 0.0003732 0.06718
2 hsa00230_Purine_metabolism 6 162 0.0007569 0.06812
3 hsa04912_GnRH_signaling_pathway 4 101 0.004641 0.2784
4 hsa04151_PI3K_AKT_signaling_pathway 7 351 0.00914 0.3652
5 hsa04730_Long.term_depression 3 70 0.01138 0.3652
6 hsa04662_B_cell_receptor_signaling_pathway 3 75 0.01371 0.3652
7 hsa04370_VEGF_signaling_pathway 3 76 0.0142 0.3652
8 hsa04012_ErbB_signaling_pathway 3 87 0.02032 0.3951
9 hsa03410_Base_excision_repair 2 34 0.02143 0.3951
10 hsa04540_Gap_junction 3 90 0.0222 0.3951
11 hsa04620_Toll.like_receptor_signaling_pathway 3 102 0.03065 0.4244
12 hsa04010_MAPK_signaling_pathway 5 268 0.03356 0.425
13 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.03542 0.425
14 hsa00480_Glutathione_metabolism 2 50 0.04369 0.4689
15 hsa04144_Endocytosis 4 203 0.04677 0.4689
16 hsa04150_mTOR_signaling_pathway 2 52 0.04689 0.4689
17 hsa04623_Cytosolic_DNA.sensing_pathway 2 56 0.05354 0.4796
18 hsa04380_Osteoclast_differentiation 3 128 0.0539 0.4796
19 hsa04360_Axon_guidance 3 130 0.05596 0.4796
20 hsa04530_Tight_junction 3 133 0.05912 0.4837
21 hsa04910_Insulin_signaling_pathway 3 138 0.06456 0.5053
22 hsa04920_Adipocytokine_signaling_pathway 2 68 0.07527 0.5558
23 hsa04115_p53_signaling_pathway 2 69 0.07719 0.5558
24 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.08108 0.5613
25 hsa04520_Adherens_junction 2 73 0.08502 0.5668
26 hsa03015_mRNA_surveillance_pathway 2 83 0.1056 0.6229
27 hsa04210_Apoptosis 2 89 0.1185 0.6462
28 hsa04970_Salivary_secretion 2 89 0.1185 0.6462
29 hsa00240_Pyrimidine_metabolism 2 99 0.1408 0.6885
30 hsa04916_Melanogenesis 2 101 0.1453 0.6885
31 hsa04972_Pancreatic_secretion 2 101 0.1453 0.6885
32 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.1804 0.778
33 hsa04722_Neurotrophin_signaling_pathway 2 127 0.2069 0.8192
34 hsa03040_Spliceosome 2 128 0.2094 0.8192
35 hsa04310_Wnt_signaling_pathway 2 151 0.2658 0.9105
36 hsa04390_Hippo_signaling_pathway 2 154 0.2732 0.9105
37 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.3076 0.9384
38 hsa04020_Calcium_signaling_pathway 2 177 0.3296 0.9416
39 hsa04510_Focal_adhesion 2 200 0.3847 1
40 hsa04014_Ras_signaling_pathway 2 236 0.4668 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP3-439F8.1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-328-3p;hsa-miR-423-3p;hsa-miR-484;hsa-miR-93-5p 14 APP Sponge network -0.149 0.78031 -0.401 0.04288 0.44
2 LINC00883 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-423-3p;hsa-miR-484;hsa-miR-582-5p 12 APP Sponge network -0.614 0.0511 -0.401 0.04288 0.424
3 RP11-426C22.4 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-361-3p 12 APP Sponge network -0.045 0.93351 -0.401 0.04288 0.404
4 RP11-967K21.1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-429;hsa-miR-93-5p 10 APP Sponge network -1.206 0.01654 -0.401 0.04288 0.4
5 LINC00702 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-328-3p;hsa-miR-423-3p;hsa-miR-484;hsa-miR-532-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-93-5p 19 APP Sponge network -2.704 0 -0.401 0.04288 0.399
6 RP11-517P14.2 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-93-5p 12 APP Sponge network -0.825 0.01106 -0.401 0.04288 0.383
7 LINC00163 hsa-let-7d-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-328-3p;hsa-miR-423-3p;hsa-miR-484 14 APP Sponge network -4.312 0.00014 -0.401 0.04288 0.378
8 GAS6-AS2 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-423-3p;hsa-miR-429 13 APP Sponge network -2.655 0 -0.401 0.04288 0.372
9 MAGI2-AS3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-423-3p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-93-5p 19 APP Sponge network -2.414 0 -0.401 0.04288 0.36
10 HCG11 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-93-5p 14 APP Sponge network -1.194 0.00331 -0.401 0.04288 0.356
11 RP11-399O19.9 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-93-5p 14 APP Sponge network -0.911 0.02612 -0.401 0.04288 0.353
12 RP11-835E18.5 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p 10 APP Sponge network -0.943 0.00219 -0.401 0.04288 0.353
13 PDZRN3-AS1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-484;hsa-miR-532-3p;hsa-miR-590-3p 15 APP Sponge network -5.049 1.0E-5 -0.401 0.04288 0.344
14 RP11-166D19.1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-328-3p;hsa-miR-361-3p;hsa-miR-429;hsa-miR-484;hsa-miR-532-3p;hsa-miR-590-3p 17 APP Sponge network -3.855 0 -0.401 0.04288 0.34
15 AC020571.3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-423-3p;hsa-miR-582-5p 14 APP Sponge network -0.862 0.18422 -0.401 0.04288 0.334
16 DNM3OS hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-328-3p;hsa-miR-429;hsa-miR-484;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-93-5p 17 APP Sponge network -2.298 1.0E-5 -0.401 0.04288 0.327
17 RP11-6O2.3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-328-3p;hsa-miR-361-3p;hsa-miR-660-5p 14 APP Sponge network -4.533 0 -0.401 0.04288 0.318
18 NR2F1-AS1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-328-3p;hsa-miR-361-3p;hsa-miR-429;hsa-miR-484;hsa-miR-532-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-93-5p 19 APP Sponge network -1.881 0 -0.401 0.04288 0.317
19 RP11-532F6.3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-423-3p;hsa-miR-590-3p 13 APP Sponge network -1.772 1.0E-5 -0.401 0.04288 0.315
20 CTD-2013N24.2 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-93-5p 16 APP Sponge network -1.002 1.0E-5 -0.401 0.04288 0.307
21 RP11-356J5.12 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-361-3p;hsa-miR-532-3p;hsa-miR-590-3p 15 APP Sponge network -2.015 0 -0.401 0.04288 0.305
22 TBX5-AS1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-328-3p;hsa-miR-532-3p 14 APP Sponge network -2.557 2.0E-5 -0.401 0.04288 0.303
23 RP11-1223D19.1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-423-3p;hsa-miR-484;hsa-miR-590-3p;hsa-miR-93-5p 14 APP Sponge network -1.23 0.05444 -0.401 0.04288 0.3
24 RP11-359E10.1 hsa-let-7d-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-484;hsa-miR-582-5p;hsa-miR-93-5p 13 APP Sponge network -1.216 0.0438 -0.401 0.04288 0.298
25 RP4-798P15.3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-423-3p;hsa-miR-484;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-660-5p 16 APP Sponge network -0.958 0.06952 -0.401 0.04288 0.296
26 VIM-AS1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-93-5p 11 APP Sponge network -1.424 0.00627 -0.401 0.04288 0.272
27 RP11-456K23.1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-429;hsa-miR-484;hsa-miR-590-3p;hsa-miR-93-5p 16 APP Sponge network -1.962 1.0E-5 -0.401 0.04288 0.271
28 MIR143HG hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-324-5p;hsa-miR-328-3p;hsa-miR-361-3p;hsa-miR-423-3p;hsa-miR-429;hsa-miR-484;hsa-miR-532-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-93-5p 22 APP Sponge network -4.237 0 -0.401 0.04288 0.268
29 RASSF8-AS1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-185-5p;hsa-miR-429;hsa-miR-484;hsa-miR-532-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-93-5p 13 APP Sponge network -0.877 0.00508 -0.401 0.04288 0.267
30 RP11-426C22.5 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-532-3p;hsa-miR-582-5p;hsa-miR-660-5p 13 APP Sponge network -0.559 0.08048 -0.401 0.04288 0.264
31 AC016747.3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-328-3p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-93-5p 15 APP Sponge network 0.026 0.94846 -0.401 0.04288 0.264
32 ZNF667-AS1 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-361-3p;hsa-miR-423-3p;hsa-miR-484;hsa-miR-93-5p 14 APP Sponge network -1.846 0.00013 -0.401 0.04288 0.258
33 RP11-554A11.4 hsa-let-7d-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p 10 APP Sponge network -3.989 0 -0.401 0.04288 0.253
34 LINC00565 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-484 11 APP Sponge network -1.493 0.05998 -0.401 0.04288 0.253
35 RP11-389G6.3 hsa-let-7d-5p;hsa-let-7g-3p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-93-5p 14 APP Sponge network -7.573 0 -0.401 0.04288 0.251

Quest ID: e8ab0072e268a744bd28144a3208f9d7