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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p ABCA1 2.49 0 -0.71 0.00276 MirTarget; miRNATAP -0.12 7.0E-5 NA
2 hsa-miR-106b-5p ABCA1 2.47 0 -0.71 0.00276 MirTarget; miRNATAP -0.21 0 NA
3 hsa-miR-93-5p ABCA1 3.04 0 -0.71 0.00276 MirTarget; miRNATAP -0.21 0 NA
4 hsa-miR-106a-5p ABCD2 2.49 0 -3.08 0 MirTarget -0.35 0 NA
5 hsa-miR-106b-5p ABCD2 2.47 0 -3.08 0 MirTarget -0.8 0 NA
6 hsa-miR-93-5p ABCD2 3.04 0 -3.08 0 MirTarget -0.74 0 NA
7 hsa-miR-106b-5p ABHD2 2.47 0 -0.37 0.12248 miRNATAP -0.13 0.00297 NA
8 hsa-miR-106b-5p ABL2 2.47 0 -0.32 0.04554 MirTarget -0.13 1.0E-5 NA
9 hsa-miR-93-5p ABL2 3.04 0 -0.32 0.04554 MirTarget -0.14 0 NA
10 hsa-miR-20a-3p ABLIM1 2.93 0 -1.72 0 mirMAP -0.12 0.00179 NA
11 hsa-miR-106a-5p ADAM19 2.49 0 -1.06 0.01895 mirMAP -0.33 0 NA
12 hsa-miR-106b-5p ADAM19 2.47 0 -1.06 0.01895 mirMAP -0.7 0 NA
13 hsa-miR-93-5p ADAM19 3.04 0 -1.06 0.01895 mirMAP -0.62 0 NA
14 hsa-miR-106b-5p ADAM9 2.47 0 -0.2 0.40665 miRNATAP -0.3 0 NA
15 hsa-miR-93-5p ADAM9 3.04 0 -0.2 0.40665 miRNATAP -0.22 0 NA
16 hsa-miR-106b-5p ADAMTS5 2.47 0 -2.16 0 miRNATAP -0.52 0 NA
17 hsa-miR-20a-3p ADAMTS6 2.93 0 -0.88 0.01914 miRNATAP -0.25 0 NA
18 hsa-miR-106a-5p ADARB1 2.49 0 -1.93 0 MirTarget -0.28 0 NA
19 hsa-miR-106b-5p ADARB1 2.47 0 -1.93 0 MirTarget -0.54 0 NA
20 hsa-miR-20a-3p ADARB1 2.93 0 -1.93 0 mirMAP -0.29 0 NA
21 hsa-miR-93-5p ADARB1 3.04 0 -1.93 0 miRNAWalker2 validate; MirTarget -0.44 0 NA
22 hsa-miR-106a-5p ADCY9 2.49 0 -1.5 0 mirMAP -0.21 0 NA
23 hsa-miR-106b-5p ADCY9 2.47 0 -1.5 0 mirMAP -0.51 0 NA
24 hsa-miR-93-5p ADCY9 3.04 0 -1.5 0 mirMAP -0.42 0 NA
25 hsa-miR-106b-5p ADRA2A 2.47 0 -2.58 0 miRNATAP -0.65 0 NA
26 hsa-miR-20a-3p AFF2 2.93 0 -1.73 0.00201 mirMAP -0.28 0.00032 NA
27 hsa-miR-106b-5p AFF4 2.47 0 -0.82 0 miRNATAP -0.11 0.00011 NA
28 hsa-miR-93-5p AFF4 3.04 0 -0.82 0 miRNATAP -0.12 0 NA
29 hsa-miR-106b-5p AGFG1 2.47 0 -0.17 0.30925 MirTarget -0.15 0 NA
30 hsa-miR-93-5p AGFG1 3.04 0 -0.17 0.30925 MirTarget -0.14 0 NA
31 hsa-miR-20a-3p AGFG2 2.93 0 -0.51 0.00539 mirMAP -0.13 0 NA
32 hsa-miR-106a-5p AHNAK 2.49 0 -1.66 0 miRNATAP -0.31 0 NA
33 hsa-miR-106b-5p AHNAK 2.47 0 -1.66 0 miRNATAP -0.55 0 NA
34 hsa-miR-93-5p AHNAK 3.04 0 -1.66 0 miRNATAP -0.47 0 NA
35 hsa-miR-106b-5p AKAP11 2.47 0 -0.8 0 miRNAWalker2 validate -0.18 0 NA
36 hsa-miR-20a-3p AKAP11 2.93 0 -0.8 0 MirTarget; miRNATAP -0.11 0 NA
37 hsa-miR-93-5p AKAP11 3.04 0 -0.8 0 miRNAWalker2 validate -0.16 0 NA
38 hsa-miR-106a-5p AKAP13 2.49 0 -1.15 0 MirTarget; mirMAP; miRNATAP -0.17 0 NA
39 hsa-miR-106b-5p AKAP13 2.47 0 -1.15 0 MirTarget; mirMAP; miRNATAP -0.34 0 NA
40 hsa-miR-93-5p AKAP13 3.04 0 -1.15 0 MirTarget; miRNATAP -0.29 0 NA
41 hsa-miR-20a-3p AKAP6 2.93 0 -3.34 0 MirTarget -0.59 0 NA
42 hsa-miR-106a-5p AKT3 2.49 0 -1.94 0 miRNATAP -0.24 0 NA
43 hsa-miR-106b-5p AKT3 2.47 0 -1.94 0 miRNATAP -0.52 0 NA
44 hsa-miR-93-5p AKT3 3.04 0 -1.94 0 miRNATAP -0.49 0 NA
45 hsa-miR-93-5p ALDH1A3 3.04 0 -1.34 0.0022 mirMAP -0.39 0 NA
46 hsa-miR-106b-5p ALDH3A2 2.47 0 -0.63 0.00987 mirMAP -0.16 0.00048 NA
47 hsa-miR-106a-5p ALPK3 2.49 0 -1.02 0.00049 mirMAP -0.13 0.00095 NA
48 hsa-miR-106b-5p ALPK3 2.47 0 -1.02 0.00049 mirMAP -0.3 0 NA
49 hsa-miR-20a-3p ANGPTL1 2.93 0 -4.51 0 MirTarget -0.9 0 NA
50 hsa-miR-106a-5p ANK2 2.49 0 -4.32 0 MirTarget; miRNATAP -0.38 0 NA
51 hsa-miR-106b-5p ANK2 2.47 0 -4.32 0 MirTarget; miRNATAP -0.94 0 NA
52 hsa-miR-93-5p ANK2 3.04 0 -4.32 0 MirTarget; miRNATAP -0.82 0 NA
53 hsa-miR-106a-5p ANKH 2.49 0 -0.38 0.21654 MirTarget -0.17 4.0E-5 NA
54 hsa-miR-106b-5p ANKH 2.47 0 -0.38 0.21654 MirTarget -0.43 0 NA
55 hsa-miR-93-5p ANKH 3.04 0 -0.38 0.21654 MirTarget -0.32 0 NA
56 hsa-miR-106a-5p ANKRD29 2.49 0 -3.47 0 MirTarget -0.51 0 NA
57 hsa-miR-106b-5p ANKRD29 2.47 0 -3.47 0 MirTarget -1.13 0 NA
58 hsa-miR-93-5p ANKRD29 3.04 0 -3.47 0 miRNAWalker2 validate; MirTarget -0.9 0 NA
59 hsa-miR-106a-5p ANKRD50 2.49 0 -0.88 0.00174 MirTarget; miRNATAP -0.11 0.0047 NA
60 hsa-miR-106b-5p ANKRD50 2.47 0 -0.88 0.00174 MirTarget; miRNATAP -0.2 0.00016 NA
61 hsa-miR-20a-3p ANKRD50 2.93 0 -0.88 0.00174 MirTarget; miRNATAP -0.13 0.00061 NA
62 hsa-miR-93-5p ANKRD50 3.04 0 -0.88 0.00174 MirTarget; miRNATAP -0.15 0.00071 NA
63 hsa-miR-106b-5p ANO6 2.47 0 -0.74 3.0E-5 MirTarget -0.13 0.00012 NA
64 hsa-miR-93-5p ANO6 3.04 0 -0.74 3.0E-5 MirTarget; miRNATAP -0.11 3.0E-5 NA
65 hsa-miR-106a-5p ANXA11 2.49 0 -0.43 0.01849 mirMAP -0.12 0 NA
66 hsa-miR-106b-5p ANXA11 2.47 0 -0.43 0.01849 mirMAP -0.15 0 NA
67 hsa-miR-20a-3p ANXA11 2.93 0 -0.43 0.01849 mirMAP -0.1 5.0E-5 NA
68 hsa-miR-106a-5p APBB2 2.49 0 -0.59 0.0014 MirTarget; miRNATAP -0.15 0 NA
69 hsa-miR-106b-5p APBB2 2.47 0 -0.59 0.0014 MirTarget; miRNATAP -0.3 0 NA
70 hsa-miR-93-5p APBB2 3.04 0 -0.59 0.0014 miRNAWalker2 validate; MirTarget; miRNATAP -0.26 0 NA
71 hsa-miR-106b-5p APCDD1 2.47 0 -1.6 0 MirTarget -0.17 0.00845 NA
72 hsa-miR-93-5p APCDD1 3.04 0 -1.6 0 MirTarget -0.16 0.0035 NA
73 hsa-miR-106a-5p APP 2.49 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.14 0 NA
74 hsa-miR-106b-5p APP 2.47 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.26 0 NA
75 hsa-miR-93-5p APP 3.04 0 -0.4 0.04288 miRNATAP -0.22 0 NA
76 hsa-miR-106a-5p ARHGAP1 2.49 0 -0.88 0 MirTarget; miRNATAP -0.17 0 NA
77 hsa-miR-106b-5p ARHGAP1 2.47 0 -0.88 0 MirTarget; miRNATAP -0.36 0 NA
78 hsa-miR-93-5p ARHGAP1 3.04 0 -0.88 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.26 0 NA
79 hsa-miR-106a-5p ARHGAP24 2.49 0 -2.02 0 MirTarget -0.33 0 NA
80 hsa-miR-106b-5p ARHGAP24 2.47 0 -2.02 0 MirTarget -0.67 0 NA
81 hsa-miR-93-5p ARHGAP24 3.04 0 -2.02 0 MirTarget -0.55 0 NA
82 hsa-miR-106b-5p ARHGAP26 2.47 0 -0.72 0.00357 MirTarget; mirMAP; miRNATAP -0.15 0.00134 NA
83 hsa-miR-93-5p ARHGAP26 3.04 0 -0.72 0.00357 MirTarget; mirMAP; miRNATAP -0.12 0.0011 NA
84 hsa-miR-106a-5p ARHGEF3 2.49 0 -0.76 0 MirTarget; miRNATAP -0.12 0 NA
85 hsa-miR-106b-5p ARHGEF3 2.47 0 -0.76 0 MirTarget; miRNATAP -0.26 0 NA
86 hsa-miR-93-5p ARHGEF3 3.04 0 -0.76 0 MirTarget; miRNATAP -0.23 0 NA
87 hsa-miR-106a-5p ARL10 2.49 0 -1.12 0.00198 mirMAP -0.2 2.0E-5 NA
88 hsa-miR-106b-5p ARL10 2.47 0 -1.12 0.00198 mirMAP -0.29 2.0E-5 NA
89 hsa-miR-93-5p ARL10 3.04 0 -1.12 0.00198 mirMAP -0.3 0 NA
90 hsa-miR-106b-5p ARL4A 2.47 0 -0.62 0.01525 miRNATAP -0.15 0.00212 NA
91 hsa-miR-106a-5p ARL4C 2.49 0 -0.28 0.33535 MirTarget; miRNATAP -0.22 0 NA
92 hsa-miR-106b-5p ARL4C 2.47 0 -0.28 0.33535 MirTarget; miRNATAP -0.39 0 NA
93 hsa-miR-93-5p ARL4C 3.04 0 -0.28 0.33535 MirTarget; miRNATAP -0.3 0 NA
94 hsa-miR-106a-5p ARSB 2.49 0 -0.58 0.00052 mirMAP -0.15 0 NA
95 hsa-miR-106b-5p ARSB 2.47 0 -0.58 0.00052 mirMAP -0.31 0 NA
96 hsa-miR-93-5p ARSJ 3.04 0 -1.58 0.00066 miRNAWalker2 validate -0.68 0 NA
97 hsa-miR-106b-5p ASAP1 2.47 0 0.06 0.77944 miRNAWalker2 validate -0.1 0.00872 NA
98 hsa-miR-93-5p ASB1 3.04 0 -0.87 0 miRNAWalker2 validate -0.13 0 NA
99 hsa-miR-93-5p ASH1L 3.04 0 -0.67 0.00016 miRNATAP -0.1 0.00015 NA
100 hsa-miR-106a-5p ASPA 2.49 0 -4.76 0 mirMAP -0.26 0.001 NA
101 hsa-miR-106b-5p ASPA 2.47 0 -4.76 0 mirMAP -0.68 0 NA
102 hsa-miR-20a-3p ASPA 2.93 0 -4.76 0 mirMAP -0.59 0 NA
103 hsa-miR-93-5p ASPA 3.04 0 -4.76 0 mirMAP -0.5 0 NA
104 hsa-miR-106a-5p ATE1 2.49 0 -1.09 3.0E-5 MirTarget -0.11 0.00166 NA
105 hsa-miR-106b-5p ATE1 2.47 0 -1.09 3.0E-5 MirTarget -0.15 0.00238 NA
106 hsa-miR-93-5p ATE1 3.04 0 -1.09 3.0E-5 MirTarget -0.19 0 NA
107 hsa-miR-106b-5p ATG16L1 2.47 0 -0.3 0.0152 MirTarget; miRNATAP -0.11 0 NA
108 hsa-miR-106b-5p ATL3 2.47 0 -0.19 0.4343 MirTarget; miRNATAP -0.24 0 NA
109 hsa-miR-93-5p ATL3 3.04 0 -0.19 0.4343 MirTarget; miRNATAP -0.2 0 NA
110 hsa-miR-106a-5p ATP1A2 2.49 0 -6.96 0 MirTarget -0.8 0 NA
111 hsa-miR-106b-5p ATP1A2 2.47 0 -6.96 0 MirTarget; miRNATAP -1.56 0 NA
112 hsa-miR-93-5p ATP1A2 3.04 0 -6.96 0 MirTarget -1.14 0 NA
113 hsa-miR-106b-5p ATP2A2 2.47 0 -0.4 0.01225 mirMAP -0.11 0.00016 NA
114 hsa-miR-20a-3p ATP8A1 2.93 0 -1.48 8.0E-5 MirTarget -0.18 0.00039 NA
115 hsa-miR-106a-5p ATXN1 2.49 0 -1.51 0 miRNATAP -0.28 0 NA
116 hsa-miR-106b-5p ATXN1 2.47 0 -1.51 0 miRNATAP -0.56 0 NA
117 hsa-miR-93-5p ATXN1 3.04 0 -1.51 0 miRNAWalker2 validate; miRNATAP -0.46 0 NA
118 hsa-miR-93-5p ATXN1L 3.04 0 -0.47 0.0041 miRNATAP -0.1 6.0E-5 NA
119 hsa-miR-93-5p B2M 3.04 0 -0 0.98848 miRNAWalker2 validate -0.23 0 NA
120 hsa-miR-106a-5p B3GALT2 2.49 0 -3.85 0 MirTarget -0.28 0 NA
121 hsa-miR-106b-5p B3GALT2 2.47 0 -3.85 0 MirTarget -0.57 0 NA
122 hsa-miR-93-5p B3GALT2 3.04 0 -3.85 0 MirTarget -0.52 0 NA
123 hsa-miR-106b-5p BACH1 2.47 0 -0.27 0.16316 mirMAP -0.15 2.0E-5 NA
124 hsa-miR-93-5p BACH1 3.04 0 -0.27 0.16316 mirMAP -0.17 0 NA
125 hsa-miR-93-5p BAG2 3.04 0 -2.37 0 miRNAWalker2 validate -0.55 0 NA
126 hsa-miR-106b-5p BBX 2.47 0 -0.51 0.00131 MirTarget; miRNATAP -0.16 0 NA
127 hsa-miR-93-5p BBX 3.04 0 -0.51 0.00131 MirTarget; miRNATAP -0.15 0 NA
128 hsa-miR-20a-3p BCL2 2.93 0 -2.02 0 mirMAP -0.21 0 NA
129 hsa-miR-106a-5p BCL2L2 2.49 0 -1.27 0 miRNATAP -0.1 1.0E-5 NA
130 hsa-miR-106b-5p BCL2L2 2.47 0 -1.27 0 miRNATAP -0.25 0 NA
131 hsa-miR-93-5p BCL2L2 3.04 0 -1.27 0 miRNATAP -0.2 0 NA
132 hsa-miR-106b-5p BCL9L 2.47 0 -0.07 0.6694 mirMAP -0.2 0 NA
133 hsa-miR-93-5p BEND4 3.04 0 -1.97 7.0E-5 mirMAP -0.26 0.00074 NA
134 hsa-miR-106b-5p BICD2 2.47 0 -0.46 0.01378 MirTarget; miRNATAP -0.11 0.00092 NA
135 hsa-miR-93-5p BICD2 3.04 0 -0.46 0.01378 MirTarget; miRNATAP -0.11 0.00012 NA
136 hsa-miR-106a-5p BMPR2 2.49 0 -0.59 4.0E-5 MirTarget; miRNATAP -0.13 0 NA
137 hsa-miR-106b-5p BMPR2 2.47 0 -0.59 4.0E-5 MirTarget; miRNATAP -0.2 0 NA
138 hsa-miR-93-5p BMPR2 3.04 0 -0.59 4.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
139 hsa-miR-106a-5p BNC2 2.49 0 -2.95 0 miRNATAP -0.6 0 NA
140 hsa-miR-106b-5p BNC2 2.47 0 -2.95 0 miRNATAP -1.15 0 NA
141 hsa-miR-93-5p BNC2 3.04 0 -2.95 0 miRNATAP -0.94 0 NA
142 hsa-miR-106b-5p BNIP3L 2.47 0 -0.6 0.00028 MirTarget -0.1 0.00077 NA
143 hsa-miR-106b-5p BRMS1L 2.47 0 -0.51 0.00391 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0 NA
144 hsa-miR-93-5p BRMS1L 3.04 0 -0.51 0.00391 MirTarget; miRNATAP -0.13 0 NA
145 hsa-miR-106b-5p BTG1 2.47 0 -0.8 2.0E-5 miRNATAP -0.19 0 NA
146 hsa-miR-106b-5p BTN3A3 2.47 0 -0.13 0.6214 miRNAWalker2 validate -0.23 0 NA
147 hsa-miR-20a-3p BVES 2.93 0 -2.76 0 mirMAP -0.35 0 NA
148 hsa-miR-20a-3p C14orf132 2.93 0 -1.97 0 mirMAP -0.32 0 NA
149 hsa-miR-106a-5p C14orf28 2.49 0 -0.89 0 miRNATAP -0.11 0 NA
150 hsa-miR-106b-5p C14orf28 2.47 0 -0.89 0 miRNATAP -0.19 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DIFFERENTIATION 124 1492 1.594e-17 7.416e-14
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 132 1672 8.063e-17 1.876e-13
3 CELL DEVELOPMENT 115 1426 2.56e-15 3.971e-12
4 NEUROGENESIS 112 1402 1.21e-14 9.381e-12
5 CARDIOVASCULAR SYSTEM DEVELOPMENT 77 788 1.111e-14 9.381e-12
6 CIRCULATORY SYSTEM DEVELOPMENT 77 788 1.111e-14 9.381e-12
7 INTRACELLULAR SIGNAL TRANSDUCTION 119 1572 7.197e-14 4.784e-11
8 TISSUE DEVELOPMENT 114 1518 4.517e-13 2.627e-10
9 RESPONSE TO ENDOGENOUS STIMULUS 110 1450 6.536e-13 3.236e-10
10 REGULATION OF CELL DEVELOPMENT 76 836 6.954e-13 3.236e-10
11 REGULATION OF CELLULAR COMPONENT MOVEMENT 72 771 8.088e-13 3.421e-10
12 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 129 1848 1.952e-12 7.567e-10
13 POSITIVE REGULATION OF GENE EXPRESSION 123 1733 2.324e-12 8.317e-10
14 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 84 1008 4.223e-12 1.404e-09
15 MUSCLE STRUCTURE DEVELOPMENT 49 432 4.979e-12 1.545e-09
16 NEURON DIFFERENTIATION 76 874 6.307e-12 1.834e-09
17 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 117 1656 1.192e-11 3.262e-09
18 REGULATION OF PHOSPHORUS METABOLIC PROCESS 115 1618 1.266e-11 3.274e-09
19 REGULATION OF NEURON DIFFERENTIATION 56 554 1.534e-11 3.756e-09
20 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 67 750 3.817e-11 8.878e-09
21 PROTEIN PHOSPHORYLATION 78 944 4.007e-11 8.878e-09
22 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 95 1275 8.197e-11 1.734e-08
23 VASCULATURE DEVELOPMENT 49 469 9.495e-11 1.921e-08
24 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 120 1784 1.451e-10 2.813e-08
25 REGULATION OF PROTEIN MODIFICATION PROCESS 116 1710 1.87e-10 3.481e-08
26 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 68 799 2.239e-10 4.004e-08
27 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 51 513 2.323e-10 4.004e-08
28 RESPONSE TO MECHANICAL STIMULUS 30 210 3.032e-10 5.039e-08
29 NEURON DEVELOPMENT 61 687 3.835e-10 6.153e-08
30 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 61 689 4.301e-10 6.672e-08
31 REGULATION OF SYSTEM PROCESS 50 507 4.635e-10 6.958e-08
32 BIOLOGICAL ADHESION 80 1032 4.791e-10 6.966e-08
33 HEART DEVELOPMENT 47 466 7.497e-10 1.057e-07
34 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 98 1395 9.766e-10 1.336e-07
35 REGULATION OF NEURON PROJECTION DEVELOPMENT 43 408 1.05e-09 1.396e-07
36 REGULATION OF CELL PROJECTION ORGANIZATION 52 558 1.527e-09 1.973e-07
37 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 77 1004 1.692e-09 2.127e-07
38 SINGLE ORGANISM BEHAVIOR 41 384 1.758e-09 2.153e-07
39 RESPONSE TO EXTERNAL STIMULUS 118 1821 2.013e-09 2.402e-07
40 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 117 1805 2.346e-09 2.729e-07
41 POSITIVE REGULATION OF LOCOMOTION 43 420 2.553e-09 2.897e-07
42 NEGATIVE REGULATION OF PHOSPHORYLATION 43 422 2.949e-09 3.259e-07
43 PHOSPHORYLATION 88 1228 3.012e-09 3.259e-07
44 MUSCLE TISSUE DEVELOPMENT 33 275 3.864e-09 4.087e-07
45 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 50 541 4.194e-09 4.242e-07
46 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 50 541 4.194e-09 4.242e-07
47 REGULATION OF CELL ADHESION 55 629 5.012e-09 4.962e-07
48 NEURON PROJECTION DEVELOPMENT 50 545 5.354e-09 5.051e-07
49 RESPONSE TO OXYGEN CONTAINING COMPOUND 95 1381 5.29e-09 5.051e-07
50 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 39 368 5.427e-09 5.051e-07
51 NEURON PROJECTION MORPHOGENESIS 41 402 6.728e-09 6.139e-07
52 LOCOMOTION 81 1114 7.139e-09 6.268e-07
53 BEHAVIOR 48 516 7.017e-09 6.268e-07
54 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 76 1021 8.001e-09 6.894e-07
55 POSITIVE REGULATION OF RESPONSE TO STIMULUS 121 1929 8.245e-09 6.976e-07
56 RESPONSE TO ABIOTIC STIMULUS 76 1024 9.074e-09 7.54e-07
57 SKELETAL SYSTEM DEVELOPMENT 44 455 9.517e-09 7.769e-07
58 POSITIVE REGULATION OF CELL DEVELOPMENT 45 472 9.954e-09 7.986e-07
59 RESPONSE TO GROWTH FACTOR 45 475 1.207e-08 9.519e-07
60 CELLULAR COMPONENT MORPHOGENESIS 69 900 1.282e-08 9.945e-07
61 NEGATIVE REGULATION OF CELL COMMUNICATION 84 1192 1.536e-08 1.172e-06
62 EPITHELIUM DEVELOPMENT 71 945 1.773e-08 1.302e-06
63 CELLULAR RESPONSE TO OXYGEN LEVELS 22 143 1.796e-08 1.302e-06
64 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 122 1977 1.818e-08 1.302e-06
65 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 73 983 1.78e-08 1.302e-06
66 BONE DEVELOPMENT 23 156 1.954e-08 1.378e-06
67 COGNITION 30 251 2.162e-08 1.502e-06
68 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 63 801 2.227e-08 1.502e-06
69 MUSCLE CELL DIFFERENTIATION 29 237 2.195e-08 1.502e-06
70 REGULATION OF MEMBRANE POTENTIAL 36 343 2.71e-08 1.801e-06
71 NEGATIVE REGULATION OF CELL DIFFERENTIATION 52 609 2.922e-08 1.915e-06
72 POSITIVE REGULATION OF MOLECULAR FUNCTION 112 1791 3.874e-08 2.504e-06
73 CELLULAR RESPONSE TO ACID CHEMICAL 24 175 4.048e-08 2.545e-06
74 BLOOD VESSEL MORPHOGENESIS 37 364 4.028e-08 2.545e-06
75 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 33 303 4.252e-08 2.638e-06
76 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 80 1142 4.507e-08 2.76e-06
77 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 28 232 5.164e-08 3.12e-06
78 POSITIVE REGULATION OF NEURON DIFFERENTIATION 33 306 5.39e-08 3.215e-06
79 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 70 957 6.46e-08 3.805e-06
80 ACTION POTENTIAL 17 94 6.631e-08 3.857e-06
81 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 41 437 7.09e-08 4.023e-06
82 CELL PROJECTION ORGANIZATION 67 902 7.08e-08 4.023e-06
83 RESPONSE TO OXYGEN LEVELS 33 311 7.94e-08 4.451e-06
84 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 90 1360 8.455e-08 4.683e-06
85 REGULATION OF ACTIN FILAMENT BASED PROCESS 33 312 8.569e-08 4.691e-06
86 CENTRAL NERVOUS SYSTEM DEVELOPMENT 65 872 9.868e-08 5.339e-06
87 RESPONSE TO WOUNDING 48 563 1.055e-07 5.602e-06
88 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 51 616 1.059e-07 5.602e-06
89 POSITIVE REGULATION OF CELL COMMUNICATION 98 1532 1.08e-07 5.647e-06
90 TELENCEPHALON DEVELOPMENT 27 228 1.322e-07 6.833e-06
91 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 79 1152 1.338e-07 6.844e-06
92 EXTRACELLULAR STRUCTURE ORGANIZATION 32 304 1.5e-07 7.588e-06
93 KIDNEY EPITHELIUM DEVELOPMENT 19 125 2.034e-07 1.017e-05
94 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 95 1492 2.147e-07 1.063e-05
95 FOREBRAIN DEVELOPMENT 35 357 2.263e-07 1.108e-05
96 RESPONSE TO HORMONE 65 893 2.338e-07 1.121e-05
97 REGULATION OF OSSIFICATION 23 178 2.33e-07 1.121e-05
98 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 72 1036 3.034e-07 1.426e-05
99 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 72 1036 3.034e-07 1.426e-05
100 POSITIVE REGULATION OF CELL DEATH 49 605 3.649e-07 1.698e-05
101 REGULATION OF MAPK CASCADE 52 660 3.744e-07 1.713e-05
102 REGULATION OF CELL MORPHOGENESIS 46 552 3.755e-07 1.713e-05
103 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 26 229 5.148e-07 2.326e-05
104 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 63 876 5.479e-07 2.451e-05
105 RESPONSE TO NITROGEN COMPOUND 62 859 5.992e-07 2.655e-05
106 MUSCLE ORGAN DEVELOPMENT 29 277 6.404e-07 2.801e-05
107 HEAD DEVELOPMENT 54 709 6.441e-07 2.801e-05
108 SYSTEM PROCESS 107 1785 6.576e-07 2.815e-05
109 POSITIVE REGULATION OF CELL DIFFERENTIATION 60 823 6.594e-07 2.815e-05
110 MULTICELLULAR ORGANISMAL SIGNALING 18 123 7.539e-07 3.189e-05
111 CELLULAR RESPONSE TO HORMONE STIMULUS 45 552 9.219e-07 3.865e-05
112 CELL CELL ADHESION 48 608 1.001e-06 4.16e-05
113 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 55 740 1.084e-06 4.466e-05
114 REGULATION OF CHEMOTAXIS 22 180 1.11e-06 4.531e-05
115 MESONEPHROS DEVELOPMENT 15 90 1.167e-06 4.72e-05
116 REGULATION OF MUSCLE SYSTEM PROCESS 23 195 1.193e-06 4.787e-05
117 ORGAN MORPHOGENESIS 60 841 1.339e-06 5.323e-05
118 CELL PART MORPHOGENESIS 49 633 1.357e-06 5.352e-05
119 CELLULAR RESPONSE TO LIPID 39 457 1.633e-06 6.297e-05
120 IMMUNE SYSTEM DEVELOPMENT 46 582 1.635e-06 6.297e-05
121 REGULATION OF CATABOLIC PROCESS 54 731 1.638e-06 6.297e-05
122 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 13 70 1.698e-06 6.475e-05
123 CELL MOTILITY 59 835 2.233e-06 8.378e-05
124 LOCALIZATION OF CELL 59 835 2.233e-06 8.378e-05
125 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 74 1135 2.279e-06 8.483e-05
126 REGULATION OF BLOOD CIRCULATION 29 295 2.314e-06 8.544e-05
127 REGULATION OF ION TRANSPORT 46 592 2.591e-06 9.492e-05
128 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 92 1517 2.747e-06 9.986e-05
129 ACTIN FILAMENT BASED PROCESS 38 450 2.85e-06 0.000102
130 RHYTHMIC PROCESS 29 298 2.832e-06 0.000102
131 UROGENITAL SYSTEM DEVELOPMENT 29 299 3.027e-06 0.0001075
132 CELLULAR RESPONSE TO NITROGEN COMPOUND 41 505 3.117e-06 0.0001099
133 REGULATION OF GTPASE ACTIVITY 50 673 3.414e-06 0.0001194
134 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 71 1087 3.475e-06 0.0001206
135 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 23 208 3.636e-06 0.0001253
136 SKELETAL MUSCLE ORGAN DEVELOPMENT 18 137 3.699e-06 0.0001266
137 CONNECTIVE TISSUE DEVELOPMENT 22 194 3.896e-06 0.0001323
138 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 31 337 4.202e-06 0.0001417
139 NEGATIVE REGULATION OF CELL PROLIFERATION 48 643 4.718e-06 0.0001579
140 REGULATION OF CELL PROLIFERATION 90 1496 4.929e-06 0.0001638
141 REGULATION OF TRANSPORT 104 1804 5.585e-06 0.0001843
142 MUSCLE CELL DEVELOPMENT 17 128 5.907e-06 0.0001936
143 IMMUNE SYSTEM PROCESS 112 1984 6.077e-06 0.0001977
144 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 6 14 6.276e-06 0.0002028
145 CARDIAC MUSCLE CELL ACTION POTENTIAL 9 37 6.691e-06 0.0002147
146 BONE MORPHOGENESIS 13 79 6.924e-06 0.0002207
147 STRIATED MUSCLE CELL DIFFERENTIATION 20 173 7.94e-06 0.0002496
148 REGULATION OF CELL SUBSTRATE ADHESION 20 173 7.94e-06 0.0002496
149 NEGATIVE REGULATION OF GENE EXPRESSION 89 1493 8.015e-06 0.0002503
150 CEREBRAL CORTEX DEVELOPMENT 15 105 8.427e-06 0.0002614
151 REGULATION OF ANATOMICAL STRUCTURE SIZE 38 472 8.649e-06 0.0002665
152 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 21 190 9.604e-06 0.000294
153 CARTILAGE DEVELOPMENT 18 147 1.007e-05 0.0003063
154 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 31 352 1.015e-05 0.0003066
155 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 8 30 1.049e-05 0.0003148
156 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 162 1.081e-05 0.0003223
157 SINGLE ORGANISM CELL ADHESION 37 459 1.102e-05 0.0003267
158 TUBE DEVELOPMENT 42 552 1.176e-05 0.0003464
159 DEVELOPMENTAL MATURATION 21 193 1.224e-05 0.0003581
160 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 39 498 1.252e-05 0.000364
161 REGULATION OF DEVELOPMENTAL GROWTH 27 289 1.307e-05 0.0003779
162 TAXIS 37 464 1.401e-05 0.0004025
163 MEMBRANE DEPOLARIZATION 11 61 1.428e-05 0.0004078
164 RESPONSE TO LIPID 59 888 1.46e-05 0.0004141
165 POSITIVE REGULATION OF CATALYTIC ACTIVITY 89 1518 1.519e-05 0.0004263
166 REGULATION OF METAL ION TRANSPORT 29 325 1.521e-05 0.0004263
167 LEUKOCYTE DIFFERENTIATION 27 292 1.575e-05 0.0004389
168 RESPONSE TO DRUG 35 431 1.623e-05 0.0004495
169 ANGIOGENESIS 27 293 1.675e-05 0.0004611
170 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 8 32 1.763e-05 0.0004826
171 REGULATION OF TRANSPORTER ACTIVITY 21 198 1.81e-05 0.0004924
172 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 26 278 1.847e-05 0.0004996
173 WOUND HEALING 37 470 1.858e-05 0.0004997
174 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 20 184 1.989e-05 0.000532
175 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 27 296 2.009e-05 0.0005343
176 HOMEOSTATIC PROCESS 80 1337 2.098e-05 0.0005546
177 CIRCULATORY SYSTEM PROCESS 31 366 2.185e-05 0.0005745
178 SENSORY ORGAN DEVELOPMENT 38 493 2.296e-05 0.0006001
179 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 6 17 2.348e-05 0.0006104
180 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 50 724 2.462e-05 0.0006363
181 NEPHRON DEVELOPMENT 15 115 2.567e-05 0.0006598
182 CELLULAR RESPONSE TO RETINOIC ACID 11 65 2.669e-05 0.0006824
183 TRANSMISSION OF NERVE IMPULSE 10 54 2.747e-05 0.0006984
184 REGULATION OF HYDROLASE ACTIVITY 79 1327 2.824e-05 0.0007141
185 REGULATION OF CELLULAR COMPONENT SIZE 29 337 2.986e-05 0.000747
186 REGULATION OF CIRCADIAN RHYTHM 14 103 2.971e-05 0.000747
187 NEURON PROJECTION GUIDANCE 21 205 3.053e-05 0.0007557
188 REGULATION OF TRANSMEMBRANE TRANSPORT 34 426 3.046e-05 0.0007557
189 ENSHEATHMENT OF NEURONS 13 91 3.33e-05 0.0008155
190 AXON ENSHEATHMENT 13 91 3.33e-05 0.0008155
191 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 20 191 3.422e-05 0.0008338
192 CHEMICAL HOMEOSTASIS 57 874 3.45e-05 0.0008362
193 ENDOCHONDRAL BONE MORPHOGENESIS 9 45 3.645e-05 0.0008756
194 CELLULAR HOMEOSTASIS 47 676 3.651e-05 0.0008756
195 REGULATION OF KINASE ACTIVITY 52 776 3.783e-05 0.0009028
196 CELLULAR RESPONSE TO MECHANICAL STIMULUS 12 80 4.057e-05 0.000963
197 ORGAN GROWTH 11 68 4.128e-05 0.0009728
198 REGULATION OF CELL DEATH 85 1472 4.14e-05 0.0009728
199 ACTIN FILAMENT BASED MOVEMENT 13 93 4.209e-05 0.0009842
200 PROTEIN LOCALIZATION 100 1805 4.329e-05 0.001007
201 REGULATION OF CARDIAC MUSCLE CELL CONTRACTION 7 27 4.629e-05 0.001072
202 RESPONSE TO BMP 13 94 4.72e-05 0.001082
203 CELLULAR RESPONSE TO BMP STIMULUS 13 94 4.72e-05 0.001082
204 POSITIVE REGULATION OF HYDROLASE ACTIVITY 58 905 4.804e-05 0.001096
205 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 34 437 5.084e-05 0.001154
206 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 18 166 5.268e-05 0.00119
207 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 24 262 5.342e-05 0.001201
208 CIRCADIAN RHYTHM 16 137 5.546e-05 0.001241
209 T CELL DIFFERENTIATION 15 123 5.695e-05 0.001268
210 CELLULAR RESPONSE TO EXTERNAL STIMULUS 24 264 6.027e-05 0.001335
211 RESPONSE TO STEROID HORMONE 37 497 6.111e-05 0.001341
212 VASCULOGENESIS 10 59 6.092e-05 0.001341
213 PALLIUM DEVELOPMENT 17 153 6.204e-05 0.001355
214 REGULATION OF RESPONSE TO STRESS 84 1468 6.323e-05 0.001375
215 REGULATION OF GROWTH 44 633 6.482e-05 0.001403
216 RESPONSE TO ACID CHEMICAL 27 319 7.374e-05 0.001571
217 GLOMERULUS DEVELOPMENT 9 49 7.393e-05 0.001571
218 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 9 49 7.393e-05 0.001571
219 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 13 98 7.341e-05 0.001571
220 HEART PROCESS 12 85 7.469e-05 0.00158
221 CARDIAC MUSCLE CELL CONTRACTION 7 29 7.622e-05 0.001605
222 NEGATIVE REGULATION OF CELL DEVELOPMENT 26 303 7.956e-05 0.00166
223 REGULATION OF HOMEOSTATIC PROCESS 34 447 7.937e-05 0.00166
224 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 8 39 8.18e-05 0.001699
225 REGULATION OF HEART RATE 12 86 8.389e-05 0.001727
226 REGULATION OF CELL SIZE 18 172 8.384e-05 0.001727
227 POSITIVE REGULATION OF CELL ADHESION 30 376 8.846e-05 0.001813
228 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 58 926 8.999e-05 0.001836
229 REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 6 21 9.056e-05 0.00184
230 POSITIVE REGULATION OF MAPK CASCADE 35 470 9.538e-05 0.00193
231 STEM CELL DIFFERENTIATION 19 190 9.938e-05 0.002002
232 REGULATION OF MUSCLE ADAPTATION 10 63 0.0001083 0.002172
233 LEARNING 15 131 0.0001176 0.002349
234 POSITIVE REGULATION OF CELL PROLIFERATION 52 814 0.0001281 0.002547
235 MESONEPHRIC TUBULE MORPHOGENESIS 9 53 0.0001395 0.002751
236 CELLULAR RESPONSE TO AMINO ACID STIMULUS 9 53 0.0001395 0.002751
237 NEGATIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 8 42 0.0001421 0.002767
238 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 8 42 0.0001421 0.002767
239 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 8 42 0.0001421 0.002767
240 METANEPHRIC NEPHRON DEVELOPMENT 7 32 0.000149 0.00289
241 REGULATION OF CYTOPLASMIC TRANSPORT 35 481 0.0001497 0.00289
242 CELLULAR RESPONSE TO ABIOTIC STIMULUS 23 263 0.0001524 0.002931
243 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 6 23 0.000158 0.003016
244 RESPONSE TO OXIDATIVE STRESS 28 352 0.0001581 0.003016
245 REGULATION OF VASOCONSTRICTION 10 66 0.0001616 0.003032
246 REGULATION OF CARDIAC MUSCLE CONTRACTION 10 66 0.0001616 0.003032
247 POSITIVE REGULATION OF CHEMOTAXIS 14 120 0.000161 0.003032
248 REGULATION OF DENDRITE DEVELOPMENT 14 120 0.000161 0.003032
249 MUSCLE SYSTEM PROCESS 24 282 0.0001674 0.003128
250 NEPHRON EPITHELIUM DEVELOPMENT 12 93 0.0001801 0.003351
251 NEGATIVE REGULATION OF KINASE ACTIVITY 22 250 0.0001925 0.003555
252 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 14 122 0.000192 0.003555
253 REGULATION OF AXONOGENESIS 17 168 0.0001969 0.003621
254 OSSIFICATION 22 251 0.0002038 0.003733
255 REGULATION OF ION HOMEOSTASIS 19 201 0.000208 0.003766
256 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 34 470 0.0002066 0.003766
257 SKELETAL SYSTEM MORPHOGENESIS 19 201 0.000208 0.003766
258 METANEPHROS DEVELOPMENT 11 81 0.0002101 0.003773
259 SPHINGOLIPID METABOLIC PROCESS 15 138 0.0002108 0.003773
260 POSITIVE REGULATION OF CATABOLIC PROCESS 30 395 0.0002105 0.003773
261 CELL ACTIVATION 39 568 0.0002142 0.003803
262 RESPONSE TO ESTROGEN 20 218 0.000214 0.003803
263 THYMOCYTE AGGREGATION 8 45 0.0002351 0.004119
264 GLYCOSPHINGOLIPID METABOLIC PROCESS 10 69 0.0002355 0.004119
265 T CELL DIFFERENTIATION IN THYMUS 8 45 0.0002351 0.004119
266 CARDIAC CONDUCTION 11 82 0.0002346 0.004119
267 NEURON MIGRATION 13 110 0.0002402 0.004186
268 CARDIAC MUSCLE TISSUE DEVELOPMENT 15 140 0.0002471 0.004289
269 REGULATION OF HEART CONTRACTION 20 221 0.0002565 0.004432
270 MEMBRANE ASSEMBLY 6 25 0.00026 0.004432
271 EPITHELIAL CELL APOPTOTIC PROCESS 6 25 0.00026 0.004432
272 RESPONSE TO CYTOKINE 46 714 0.0002579 0.004432
273 EPITHELIAL CELL DIFFERENTIATION 35 495 0.0002583 0.004432
274 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 10 70 0.0002657 0.004511
275 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 14 126 0.0002698 0.004565
276 REGULATION OF OSTEOBLAST DIFFERENTIATION 13 112 0.0002875 0.004847
277 NEGATIVE REGULATION OF CELL ADHESION 20 223 0.0002889 0.004852
278 PROTEIN DEPHOSPHORYLATION 18 190 0.0002944 0.004928
279 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 30 404 0.0003091 0.005155
280 RAS PROTEIN SIGNAL TRANSDUCTION 15 143 0.0003115 0.005176
281 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 7 36 0.0003245 0.005374
282 ENTRAINMENT OF CIRCADIAN CLOCK 6 26 0.0003274 0.005403
283 CARDIAC CHAMBER DEVELOPMENT 15 144 0.0003359 0.005523
284 LYMPHOCYTE DIFFERENTIATION 19 209 0.0003423 0.005607
285 CELL JUNCTION ASSEMBLY 14 129 0.0003445 0.005625
286 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 40 602 0.0003484 0.005668
287 REPRODUCTIVE SYSTEM DEVELOPMENT 30 408 0.0003648 0.005914
288 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 9 60 0.0003686 0.005956
289 REGULATION OF PROTEIN AUTOPHOSPHORYLATION 7 37 0.0003875 0.006238
290 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 15 146 0.0003898 0.006254
291 CELL MATURATION 14 131 0.0004037 0.006455
292 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 13 116 0.0004061 0.006472
293 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 6 27 0.0004078 0.006475
294 REGULATION OF MUSCLE CONTRACTION 15 147 0.0004194 0.006635
295 ACTIN MEDIATED CELL CONTRACTION 10 74 0.0004207 0.006635
296 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 12 102 0.00043 0.006737
297 RENAL SYSTEM PROCESS 12 102 0.00043 0.006737
298 RESPIRATORY SYSTEM DEVELOPMENT 18 197 0.0004566 0.00713
299 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 7 38 0.0004598 0.007155
300 NEGATIVE REGULATION OF CELL CYCLE 31 433 0.0004622 0.007169
301 LEUKOCYTE ACTIVATION 30 414 0.000465 0.007188
302 TISSUE MORPHOGENESIS 36 533 0.0005022 0.007719
303 MUSCLE HYPERTROPHY 6 28 0.0005027 0.007719
304 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 37 554 0.0005211 0.00785
305 NEGATIVE REGULATION OF PROTEIN AUTOPHOSPHORYLATION 4 11 0.0005216 0.00785
306 NEGATIVE REGULATION OF GLYCOLYTIC PROCESS 4 11 0.0005216 0.00785
307 POSITIVE REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 4 11 0.0005216 0.00785
308 NEGATIVE REGULATION OF COENZYME METABOLIC PROCESS 4 11 0.0005216 0.00785
309 TUBE MORPHOGENESIS 25 323 0.000523 0.00785
310 NEGATIVE REGULATION OF COFACTOR METABOLIC PROCESS 4 11 0.0005216 0.00785
311 CALCIUM MEDIATED SIGNALING 11 90 0.000532 0.007959
312 ADULT BEHAVIOR 14 135 0.0005483 0.008099
313 KIDNEY VASCULATURE DEVELOPMENT 5 19 0.0005455 0.008099
314 REGULATION OF CELL CELL ADHESION 28 380 0.0005469 0.008099
315 RENAL SYSTEM VASCULATURE DEVELOPMENT 5 19 0.0005455 0.008099
316 ION HOMEOSTASIS 38 576 0.0005561 0.008188
317 POSITIVE REGULATION OF ION TRANSPORT 20 236 0.0005995 0.0088
318 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 13 121 0.0006107 0.008908
319 CELL JUNCTION ORGANIZATION 17 185 0.0006093 0.008908
320 RESPONSE TO ISCHEMIA 6 29 0.0006139 0.008927
321 EMBRYONIC MORPHOGENESIS 36 539 0.0006163 0.008933
322 APPENDAGE DEVELOPMENT 16 169 0.0006306 0.009084
323 LIMB DEVELOPMENT 16 169 0.0006306 0.009084
324 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 11 92 0.0006425 0.009199
325 REGULATION OF INTRACELLULAR TRANSPORT 40 621 0.000642 0.009199
326 PLASMA MEMBRANE ORGANIZATION 18 203 0.0006522 0.009309
327 RESPONSE TO PEPTIDE 29 404 0.0006674 0.009467
328 EMBRYO DEVELOPMENT 53 894 0.0006665 0.009467
329 CELLULAR RESPONSE TO PEPTIDE 22 274 0.0006811 0.009632
330 RESPONSE TO MUSCLE ACTIVITY 5 20 0.0007051 0.009941
331 DENDRITE DEVELOPMENT 10 79 0.0007135 0.009999
332 REGULATION OF STRIATED MUSCLE CONTRACTION 10 79 0.0007135 0.009999
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 119 1737 5.574e-11 5.178e-08
2 KINASE ACTIVITY 67 842 4.875e-09 1.525e-06
3 MACROMOLECULAR COMPLEX BINDING 96 1399 4.926e-09 1.525e-06
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 36 328 8.43e-09 1.958e-06
5 PROTEIN KINASE ACTIVITY 54 640 2.348e-08 4.363e-06
6 CYTOSKELETAL PROTEIN BINDING 63 819 5.054e-08 7.47e-06
7 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 72 992 5.629e-08 7.47e-06
8 PROTEIN COMPLEX BINDING 68 935 1.25e-07 1.452e-05
9 IDENTICAL PROTEIN BINDING 81 1209 2.417e-07 2.495e-05
10 KINASE BINDING 49 606 3.832e-07 3.362e-05
11 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 26 226 3.981e-07 3.362e-05
12 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 50 629 4.845e-07 3.751e-05
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 31 315 1.019e-06 7.284e-05
14 ACTIN BINDING 35 393 2.143e-06 0.0001422
15 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 77 1199 2.466e-06 0.0001527
16 PROTEIN DIMERIZATION ACTIVITY 74 1149 3.545e-06 0.0002058
17 PROTEIN DOMAIN SPECIFIC BINDING 47 624 4.676e-06 0.0002555
18 RECEPTOR BINDING 89 1476 5.111e-06 0.0002638
19 BINDING BRIDGING 20 173 7.94e-06 0.0003882
20 MOLECULAR FUNCTION REGULATOR 82 1353 1.031e-05 0.0004791
21 RIBONUCLEOTIDE BINDING 104 1860 2.046e-05 0.0009053
22 GLYCOPROTEIN BINDING 14 101 2.373e-05 0.001002
23 PROTEIN SERINE THREONINE KINASE ACTIVITY 35 445 3.167e-05 0.001279
24 REGULATORY REGION NUCLEIC ACID BINDING 54 818 4.02e-05 0.001556
25 PROTEIN HOMODIMERIZATION ACTIVITY 49 722 4.611e-05 0.001714
26 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 6 20 6.679e-05 0.002387
27 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 15 133 0.0001396 0.004641
28 CALMODULIN BINDING 18 179 0.0001399 0.004641
29 CALCIUM ION BINDING 46 697 0.00015 0.004805
30 TUBULIN BINDING 23 273 0.0002629 0.007879
31 RECEPTOR SIGNALING PROTEIN ACTIVITY 17 172 0.0002609 0.007879
32 SEQUENCE SPECIFIC DNA BINDING 61 1037 0.0003259 0.009461
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 97 1265 1.005e-11 2.934e-09
2 MEMBRANE REGION 90 1134 9.816e-12 2.934e-09
3 CELL JUNCTION 88 1151 1.201e-10 1.753e-08
4 NEURON PROJECTION 77 942 9.013e-11 1.753e-08
5 CELL PROJECTION 120 1786 1.556e-10 1.817e-08
6 MEMBRANE MICRODOMAIN 35 288 9.258e-10 9.011e-08
7 ACTIN CYTOSKELETON 45 444 1.489e-09 1.242e-07
8 SYNAPSE 62 754 5.51e-09 4.022e-07
9 INTRINSIC COMPONENT OF PLASMA MEMBRANE 104 1649 8.443e-08 5.478e-06
10 SOMATODENDRITIC COMPARTMENT 53 650 9.704e-08 5.667e-06
11 CYTOSKELETON 118 1967 1.508e-07 8.008e-06
12 ANCHORING JUNCTION 43 489 2.111e-07 1.027e-05
13 POSTSYNAPSE 36 378 3.102e-07 1.394e-05
14 CELL SUBSTRATE JUNCTION 36 398 1.067e-06 4.452e-05
15 DENDRITE 39 451 1.179e-06 4.591e-05
16 MAIN AXON 12 58 1.276e-06 4.656e-05
17 CELL PROJECTION PART 65 946 1.739e-06 5.974e-05
18 PLASMA MEMBRANE REGION 64 929 1.921e-06 6.232e-05
19 BASAL PLASMA MEMBRANE 9 33 2.373e-06 7.293e-05
20 SYNAPSE PART 47 610 2.538e-06 7.41e-05
21 SARCOLEMMA 17 125 4.261e-06 0.0001185
22 SIDE OF MEMBRANE 36 428 5.668e-06 0.0001505
23 AXON 35 418 8.417e-06 0.0002048
24 CELL CELL JUNCTION 33 383 8.389e-06 0.0002048
25 PLASMA MEMBRANE PROTEIN COMPLEX 40 510 9.365e-06 0.0002188
26 INTRACELLULAR VESICLE 77 1259 1.429e-05 0.0003209
27 VACUOLE 73 1180 1.652e-05 0.0003445
28 BASAL PART OF CELL 10 51 1.623e-05 0.0003445
29 PLASMA MEMBRANE RAFT 13 86 1.795e-05 0.0003615
30 CELL LEADING EDGE 30 350 2.359e-05 0.0004591
31 T TUBULE 9 45 3.645e-05 0.0006867
32 I BAND 15 121 4.699e-05 0.0008316
33 CONTRACTILE FIBER 21 211 4.679e-05 0.0008316
34 CATION CHANNEL COMPLEX 18 167 5.702e-05 0.0009794
35 EXTRACELLULAR MATRIX COMPONENT 15 125 6.87e-05 0.001146
36 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 0.0001098 0.001781
37 CELL BODY 36 494 0.0001174 0.001854
38 ENDOPLASMIC RETICULUM 90 1631 0.0001246 0.001915
39 PROTEIN KINASE COMPLEX 12 90 0.0001311 0.001963
40 APICAL DENDRITE 5 15 0.0001596 0.00233
41 COATED PIT 10 67 0.0001837 0.002495
42 PERINUCLEAR REGION OF CYTOPLASM 43 642 0.0001781 0.002495
43 BASEMENT MEMBRANE 12 93 0.0001801 0.002495
44 LYTIC VACUOLE 37 526 0.0001927 0.002558
45 CYTOPLASMIC SIDE OF MEMBRANE 17 170 0.0002269 0.002767
46 A BAND 7 34 0.0002232 0.002767
47 EXTRINSIC COMPONENT OF MEMBRANE 22 252 0.0002156 0.002767
48 AXON PART 20 219 0.0002274 0.002767
49 CELL SURFACE 48 757 0.0002742 0.003268
50 CORTICAL ACTIN CYTOSKELETON 9 58 0.0002838 0.003315
51 SODIUM CHANNEL COMPLEX 5 17 0.0003089 0.003538
52 TRANSCRIPTIONAL REPRESSOR COMPLEX 10 74 0.0004207 0.004724
53 PROTEINACEOUS EXTRACELLULAR MATRIX 27 356 0.0004378 0.004824
54 EXCITATORY SYNAPSE 18 197 0.0004566 0.004938
55 SITE OF POLARIZED GROWTH 15 149 0.0004845 0.005144
56 CYTOSKELETAL PART 78 1436 0.0005751 0.005997
57 CELL CELL CONTACT ZONE 9 64 0.0006013 0.006045
58 NEURON SPINE 13 121 0.0006107 0.006045
59 MYELIN SHEATH 16 168 0.0005909 0.006045
60 LAMELLIPODIUM 16 172 0.0007636 0.00731
61 ENDOSOME 48 793 0.0007625 0.00731
62 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 6 31 0.0008929 0.00841
63 TRANSPORTER COMPLEX 24 321 0.001084 0.009985
64 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 11 98 0.001094 0.009985

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 21 200 2.107e-05 0.0009998
2 hsa04380_Osteoclast_differentiation 16 128 2.39e-05 0.0009998
3 hsa04151_PI3K_AKT_signaling_pathway 30 351 2.489e-05 0.0009998
4 hsa04210_Apoptosis 13 89 2.616e-05 0.0009998
5 hsa04010_MAPK_signaling_pathway 25 268 2.777e-05 0.0009998
6 hsa04710_Circadian_rhythm_._mammal 6 23 0.000158 0.004741
7 hsa04514_Cell_adhesion_molecules_.CAMs. 14 136 0.0005906 0.01519
8 hsa04722_Neurotrophin_signaling_pathway 13 127 0.000965 0.02096
9 hsa04115_p53_signaling_pathway 9 69 0.001048 0.02096
10 hsa04390_Hippo_signaling_pathway 14 154 0.001978 0.03439
11 hsa04630_Jak.STAT_signaling_pathway 14 155 0.002102 0.03439
12 hsa04920_Adipocytokine_signaling_pathway 8 68 0.003793 0.0569
13 hsa04660_T_cell_receptor_signaling_pathway 10 108 0.007306 0.1006
14 hsa04014_Ras_signaling_pathway 17 236 0.007824 0.1006
15 hsa04270_Vascular_smooth_muscle_contraction 10 116 0.01182 0.1418
16 hsa04910_Insulin_signaling_pathway 11 138 0.01477 0.1621
17 hsa04020_Calcium_signaling_pathway 13 177 0.01603 0.1621
18 hsa04012_ErbB_signaling_pathway 8 87 0.01621 0.1621
19 hsa04360_Axon_guidance 10 130 0.02438 0.2309
20 hsa04310_Wnt_signaling_pathway 11 151 0.02683 0.2415
21 hsa04912_GnRH_signaling_pathway 8 101 0.03579 0.3068
22 hsa04144_Endocytosis 13 203 0.04246 0.3285
23 hsa04150_mTOR_signaling_pathway 5 52 0.04447 0.3285
24 hsa04914_Progesterone.mediated_oocyte_maturation 7 87 0.04455 0.3285
25 hsa04720_Long.term_potentiation 6 70 0.04694 0.3285
26 hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate 3 22 0.04745 0.3285
27 hsa04540_Gap_junction 7 90 0.05186 0.3457
28 hsa04971_Gastric_acid_secretion 6 74 0.05866 0.3629
29 hsa04810_Regulation_of_actin_cytoskeleton 13 214 0.05981 0.3629
30 hsa04662_B_cell_receptor_signaling_pathway 6 75 0.06184 0.3629
31 hsa04530_Tight_junction 9 133 0.0625 0.3629
32 hsa00052_Galactose_metabolism 3 27 0.07867 0.4425
33 hsa04973_Carbohydrate_digestion_and_absorption 4 44 0.08158 0.445
34 hsa04620_Toll.like_receptor_signaling_pathway 7 102 0.08828 0.4674
35 hsa00340_Histidine_metabolism 3 29 0.09312 0.4789
36 hsa04062_Chemokine_signaling_pathway 11 189 0.09904 0.4952
37 hsa00604_Glycosphingolipid_biosynthesis_._ganglio_series 2 15 0.1066 0.5188
38 hsa04672_Intestinal_immune_network_for_IgA_production 4 49 0.1105 0.5232
39 hsa00770_Pantothenate_and_CoA_biosynthesis 2 16 0.119 0.5466
40 hsa04730_Long.term_depression 5 70 0.1215 0.5466
41 hsa04614_Renin.angiotensin_system 2 17 0.1316 0.5779
42 hsa04114_Oocyte_meiosis 7 114 0.1361 0.5781
43 hsa04520_Adherens_junction 5 73 0.1381 0.5781
44 hsa00500_Starch_and_sucrose_metabolism 4 54 0.1432 0.5835
45 hsa04666_Fc_gamma_R.mediated_phagocytosis 6 95 0.1459 0.5835
46 hsa00051_Fructose_and_mannose_metabolism 3 36 0.151 0.5908
47 hsa00531_Glycosaminoglycan_degradation 2 19 0.1578 0.6042
48 hsa04142_Lysosome 7 121 0.1687 0.6328
49 hsa04916_Melanogenesis 6 101 0.1779 0.6405
50 hsa04972_Pancreatic_secretion 6 101 0.1779 0.6405
51 hsa00600_Sphingolipid_metabolism 3 40 0.188 0.6637
52 hsa00410_beta.Alanine_metabolism 2 22 0.1985 0.6871
53 hsa04960_Aldosterone.regulated_sodium_reabsorption 3 42 0.2074 0.698
54 hsa04350_TGF.beta_signaling_pathway 5 85 0.2133 0.698
55 hsa04512_ECM.receptor_interaction 5 85 0.2133 0.698
56 hsa00010_Glycolysis_._Gluconeogenesis 4 65 0.2259 0.7049
57 hsa00310_Lysine_degradation 3 44 0.2271 0.7049
58 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.2271 0.7049
59 hsa04970_Salivary_secretion 5 89 0.2408 0.7346
60 hsa04650_Natural_killer_cell_mediated_cytotoxicity 7 136 0.2485 0.7454
61 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 3 48 0.2676 0.7864
62 hsa04670_Leukocyte_transendothelial_migration 6 117 0.2746 0.7864
63 hsa04976_Bile_secretion 4 71 0.2753 0.7864
64 hsa00561_Glycerolipid_metabolism 3 50 0.2881 0.8103
65 hsa04370_VEGF_signaling_pathway 4 76 0.3176 0.8795
66 hsa04260_Cardiac_muscle_contraction 4 77 0.3261 0.8894
67 hsa00040_Pentose_and_glucuronate_interconversions 2 32 0.3382 0.9078
68 hsa04340_Hedgehog_signaling_pathway 3 56 0.3501 0.9133
69 hsa04145_Phagosome 7 156 0.3677 0.9456
70 hsa00565_Ether_lipid_metabolism 2 36 0.3926 0.9952
71 hsa00230_Purine_metabolism 7 162 0.4046 1
72 hsa04120_Ubiquitin_mediated_proteolysis 6 139 0.4208 1
73 hsa00071_Fatty_acid_metabolism 2 43 0.4824 1
74 hsa03320_PPAR_signaling_pathway 3 70 0.4902 1
75 hsa02010_ABC_transporters 2 44 0.4945 1
76 hsa04110_Cell_cycle 5 128 0.5258 1
77 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.5634 1
78 hsa04612_Antigen_processing_and_presentation 3 78 0.5634 1
79 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.572 1
80 hsa00564_Glycerophospholipid_metabolism 3 80 0.5806 1
81 hsa00983_Drug_metabolism_._other_enzymes 2 52 0.5849 1
82 hsa04974_Protein_digestion_and_absorption 3 81 0.5891 1
83 hsa04141_Protein_processing_in_endoplasmic_reticulum 6 168 0.6045 1
84 hsa00140_Steroid_hormone_biosynthesis 2 57 0.6351 1
85 hsa00562_Inositol_phosphate_metabolism 2 57 0.6351 1
86 hsa04640_Hematopoietic_cell_lineage 3 88 0.6452 1
87 hsa00590_Arachidonic_acid_metabolism 2 59 0.6538 1
88 hsa00240_Pyrimidine_metabolism 3 99 0.722 1
89 hsa03015_mRNA_surveillance_pathway 2 83 0.8226 1
90 hsa04740_Olfactory_transduction 2 388 1 1

Quest ID: ee1d6804eaaa226daa435884127711c2