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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-141-3p ABL1 5.02 0 -1.32 0 MirTarget -0.18 0 NA
2 hsa-miR-141-3p ABL2 5.02 0 -0.32 0.04554 MirTarget; TargetScan; miRNATAP -0.13 0 NA
3 hsa-miR-141-3p ACO1 5.02 0 -0.65 0.00055 MirTarget; TargetScan -0.13 0 NA
4 hsa-miR-141-3p ADARB1 5.02 0 -1.93 0 MirTarget -0.34 0 NA
5 hsa-miR-141-3p AFAP1 5.02 0 -0.98 0.00012 mirMAP -0.24 0 NA
6 hsa-miR-141-3p AKAP2 5.02 0 -2.51 8.0E-5 TargetScan -0.59 0 NA
7 hsa-miR-141-3p AMOTL1 5.02 0 -1.62 0 TargetScan -0.26 0 NA
8 hsa-miR-141-3p AMZ1 5.02 0 0.48 0.33638 mirMAP -0.17 0.00019 NA
9 hsa-miR-141-3p ANGPTL1 5.02 0 -4.51 0 MirTarget -0.76 0 NA
10 hsa-miR-141-3p ANK2 5.02 0 -4.32 0 TargetScan; miRNATAP -0.68 0 NA
11 hsa-miR-141-3p ANKRD44 5.02 0 -1.93 0 TargetScan -0.35 0 NA
12 hsa-miR-141-3p ANO5 5.02 0 -3.19 0 mirMAP -0.3 0 NA
13 hsa-miR-141-3p APBB2 5.02 0 -0.59 0.0014 MirTarget; TargetScan -0.17 0 NA
14 hsa-miR-141-3p APOLD1 5.02 0 -2.62 0 TargetScan -0.24 0 NA
15 hsa-miR-141-3p ARHGAP24 5.02 0 -2.02 0 TargetScan; miRNATAP -0.38 0 NA
16 hsa-miR-141-3p ARID5B 5.02 0 -1.57 0 TargetScan; miRNATAP -0.16 0 NA
17 hsa-miR-141-3p ARL10 5.02 0 -1.12 0.00198 mirMAP -0.25 0 NA
18 hsa-miR-141-3p ARL4A 5.02 0 -0.62 0.01525 TargetScan -0.1 1.0E-5 NA
19 hsa-miR-141-3p ARNT2 5.02 0 -1.45 0.00019 mirMAP -0.13 0.00022 NA
20 hsa-miR-141-3p ARNTL 5.02 0 -0.36 0.08956 MirTarget; TargetScan; miRNATAP -0.1 0 NA
21 hsa-miR-141-3p ASB1 5.02 0 -0.87 0 mirMAP -0.12 0 NA
22 hsa-miR-141-3p ASTN1 5.02 0 -2.34 2.0E-5 MirTarget; miRNATAP -0.14 0.00582 NA
23 hsa-miR-141-3p ASXL3 5.02 0 -3.34 0 TargetScan -0.31 0 NA
24 hsa-miR-141-3p ATP8A1 5.02 0 -1.48 8.0E-5 MirTarget; TargetScan -0.16 1.0E-5 NA
25 hsa-miR-141-3p ATXN1 5.02 0 -1.51 0 MirTarget; TargetScan; miRNATAP -0.24 0 NA
26 hsa-miR-141-3p BACE1 5.02 0 -0.72 0.00096 TargetScan; miRNATAP -0.22 0 NA
27 hsa-miR-141-3p BACH2 5.02 0 -1.52 0.00134 TargetScan -0.49 0 NA
28 hsa-miR-141-3p BEND4 5.02 0 -1.97 7.0E-5 TargetScan; miRNATAP -0.29 0 NA
29 hsa-miR-141-3p BNC2 5.02 0 -2.95 0 TargetScan -0.63 0 NA
30 hsa-miR-141-3p BVES 5.02 0 -2.76 0 mirMAP -0.48 0 NA
31 hsa-miR-141-3p C11orf21 5.02 0 -1.31 0.00227 mirMAP -0.24 0 NA
32 hsa-miR-141-3p CACNA2D1 5.02 0 -3.32 0 TargetScan -0.71 0 NA
33 hsa-miR-141-3p CADM1 5.02 0 -1.19 0.01251 MirTarget; TargetScan -0.16 0.00033 NA
34 hsa-miR-141-3p CADM2 5.02 0 -3.84 0 TargetScan; miRNATAP -0.3 0 NA
35 hsa-miR-141-3p CALU 5.02 0 -0.15 0.46318 TargetScan -0.2 0 NA
36 hsa-miR-141-3p CAMK4 5.02 0 -1.28 0.0022 mirMAP -0.29 0 NA
37 hsa-miR-141-3p CCDC80 5.02 0 -3.33 0 MirTarget; TargetScan -0.69 0 NA
38 hsa-miR-141-3p CCND2 5.02 0 -2.43 0 MirTarget; TargetScan -0.34 0 NA
39 hsa-miR-141-3p CCPG1 5.02 0 -1 0 MirTarget; miRNATAP -0.19 0 NA
40 hsa-miR-141-3p CD274 5.02 0 0.06 0.90454 MirTarget -0.22 0 NA
41 hsa-miR-141-3p CD59 5.02 0 -0.7 0.0013 mirMAP -0.1 0 NA
42 hsa-miR-141-3p CDC25B 5.02 0 0.78 0.00479 TargetScan -0.12 0 NA
43 hsa-miR-141-3p CDC42EP3 5.02 0 -1.35 0 MirTarget; TargetScan -0.22 0 NA
44 hsa-miR-141-3p CDK6 5.02 0 -0.77 0.06479 TargetScan; miRNATAP -0.28 0 NA
45 hsa-miR-141-3p CDON 5.02 0 -2.61 0 TargetScan; miRNATAP -0.4 0 NA
46 hsa-miR-141-3p CDV3 5.02 0 -0.42 0.0021 TargetScan; miRNATAP -0.11 0 NA
47 hsa-miR-141-3p CELF2 5.02 0 -3.05 0 mirMAP; miRNATAP -0.47 0 NA
48 hsa-miR-141-3p CEP170 5.02 0 -0.11 0.58268 TargetScan -0.14 0 NA
49 hsa-miR-141-3p CFL2 5.02 0 -2.62 0 TargetScan -0.42 0 NA
50 hsa-miR-141-3p CHRDL1 5.02 0 -6.15 0 MirTarget; TargetScan -0.9 0 NA
51 hsa-miR-141-3p CLIC4 5.02 0 -1.72 0 MirTarget -0.4 0 NA
52 hsa-miR-141-3p CLIP2 5.02 0 -0.8 0.00158 MirTarget; TargetScan -0.15 0 NA
53 hsa-miR-141-3p CNTN1 5.02 0 -4.98 0 MirTarget; TargetScan; miRNATAP -0.75 0 NA
54 hsa-miR-141-3p COL11A1 5.02 0 4.69 0 miRNATAP -0.23 0.00397 NA
55 hsa-miR-141-3p COL15A1 5.02 0 -0.94 0.00988 MirTarget -0.34 0 NA
56 hsa-miR-141-3p COL8A1 5.02 0 -0.75 0.115 mirMAP -0.38 0 NA
57 hsa-miR-141-3p CORO1C 5.02 0 -1.12 0 TargetScan -0.25 0 NA
58 hsa-miR-141-3p CPEB4 5.02 0 -1.56 0 TargetScan -0.12 0 NA
59 hsa-miR-141-3p CREB5 5.02 0 -2.28 0 mirMAP -0.41 0 NA
60 hsa-miR-141-3p CRMP1 5.02 0 -1.11 0.00158 MirTarget; TargetScan -0.23 0 NA
61 hsa-miR-141-3p CSF3 5.02 0 -4.55 0 TargetScan; miRNATAP -0.54 0 NA
62 hsa-miR-141-3p CTSB 5.02 0 0.1 0.67673 mirMAP -0.17 0 NA
63 hsa-miR-141-3p CTTNBP2 5.02 0 -2.9 1.0E-5 miRNATAP -0.24 7.0E-5 NA
64 hsa-miR-141-3p CXCL12 5.02 0 -3.26 0 miRNATAP -0.58 0 NA
65 hsa-miR-141-3p CYLD 5.02 0 -0.89 0 mirMAP -0.14 0 NA
66 hsa-miR-141-3p CYP26B1 5.02 0 -0.69 0.15191 MirTarget; TargetScan; miRNATAP -0.38 0 NA
67 hsa-miR-141-3p DIO2 5.02 0 -0.24 0.63454 miRNATAP -0.29 0 NA
68 hsa-miR-141-3p DLC1 5.02 0 -1.8 0 TargetScan; miRNATAP -0.21 0 26278151 MicroRNA 141 regulates the tumour suppressor DLC1 in colorectal cancer; Luciferase reporter assays and Western blots showed that DLC1 was a direct target of miR-141 in CRC; The expression levels of miR-141 were obviously up-regulated in CRC tissues compared to non-cancerous tissues while DLC1 expression levels were down-regulated in a high proportion of clinical samples 14/18; In addition correlation analyses revealed negative correlation between miR-141 levels and DLC1 expression levels in CRC tissues; In conclusion we demonstrated that miR-141 is up-regulated in CRC and acts as a functional oncogene by targeting DLC1
69 hsa-miR-141-3p DOCK4 5.02 0 -0.48 0.07912 MirTarget; TargetScan -0.18 0 NA
70 hsa-miR-141-3p DPYSL3 5.02 0 -2.32 0 TargetScan -0.54 0 NA
71 hsa-miR-141-3p DSEL 5.02 0 -1.79 0 TargetScan -0.29 0 NA
72 hsa-miR-141-3p DST 5.02 0 -1.12 9.0E-5 mirMAP -0.12 0 NA
73 hsa-miR-141-3p DUSP1 5.02 0 -3.47 0 TargetScan -0.34 0 NA
74 hsa-miR-141-3p DUSP3 5.02 0 -1.04 0 MirTarget; TargetScan; miRNATAP -0.15 0 NA
75 hsa-miR-141-3p DYNC1I1 5.02 0 -2.05 0.0001 MirTarget -0.21 1.0E-5 NA
76 hsa-miR-141-3p DZIP1 5.02 0 -1.57 2.0E-5 TargetScan; miRNATAP -0.29 0 NA
77 hsa-miR-141-3p EGR2 5.02 0 -2.81 0 TargetScan; miRNATAP -0.47 0 NA
78 hsa-miR-141-3p ELK3 5.02 0 -0.31 0.25641 TargetScan -0.19 0 NA
79 hsa-miR-141-3p ELL2 5.02 0 -1.08 1.0E-5 TargetScan -0.13 0 NA
80 hsa-miR-141-3p ENAH 5.02 0 -0.68 0.00063 TargetScan -0.15 0 NA
81 hsa-miR-141-3p EPB41L3 5.02 0 -1.63 7.0E-5 miRNATAP -0.29 0 NA
82 hsa-miR-141-3p EPHA7 5.02 0 -4.2 0 TargetScan; miRNATAP -0.33 0 26261572 Among those the expression of EPHA7 and PI15 were negatively correlated with that of microRNA-141 and they were also identified as potential targets of this microRNA via microRNA-mRNA interaction; We thus concluded that microRNA-141 EPHA7 and PI15 might jointly participate in the regulation of drug resistance in ovarian cancer and serve as potential targets in targeted therapies
83 hsa-miR-141-3p ERC2 5.02 0 -0.08 0.86617 MirTarget; TargetScan -0.11 0.01934 NA
84 hsa-miR-141-3p ERG 5.02 0 -1.35 0 MirTarget; TargetScan -0.25 0 NA
85 hsa-miR-141-3p ETS1 5.02 0 -0.7 0.00228 mirMAP -0.14 0 NA
86 hsa-miR-141-3p FAM133A 5.02 0 -0.54 0.49453 mirMAP -0.31 1.0E-5 NA
87 hsa-miR-141-3p FAM167A 5.02 0 0.27 0.48779 mirMAP -0.19 0 NA
88 hsa-miR-141-3p FAM168A 5.02 0 -0.72 0.00481 TargetScan -0.17 0 NA
89 hsa-miR-141-3p FAM168B 5.02 0 -0.95 0 MirTarget; TargetScan -0.11 0 NA
90 hsa-miR-141-3p FAM20C 5.02 0 -1.33 0.00181 MirTarget -0.46 0 NA
91 hsa-miR-141-3p FAM26E 5.02 0 -1.51 4.0E-5 mirMAP -0.41 0 NA
92 hsa-miR-141-3p FAM46C 5.02 0 -1.66 0 TargetScan; miRNATAP -0.11 0.00024 NA
93 hsa-miR-141-3p FAT3 5.02 0 -2.79 0 MirTarget; miRNATAP -0.24 1.0E-5 NA
94 hsa-miR-141-3p FER 5.02 0 -0.96 0.00017 mirMAP -0.18 0 NA
95 hsa-miR-141-3p FGF13 5.02 0 -2.8 0 TargetScan -0.3 0 NA
96 hsa-miR-141-3p FKBP5 5.02 0 -1.54 4.0E-5 TargetScan -0.39 0 NA
97 hsa-miR-141-3p FLI1 5.02 0 -1.11 7.0E-5 TargetScan -0.28 0 NA
98 hsa-miR-141-3p FNIP2 5.02 0 -0.76 0.01045 TargetScan -0.15 0 NA
99 hsa-miR-141-3p FOXN3 5.02 0 -1.44 0 MirTarget; TargetScan; miRNATAP -0.14 0 NA
100 hsa-miR-141-3p FOXP2 5.02 0 -3.99 0 TargetScan -0.49 0 NA
101 hsa-miR-141-3p FRMD6 5.02 0 -0.93 0.00183 MirTarget; TargetScan; miRNATAP -0.12 2.0E-5 NA
102 hsa-miR-141-3p FSD1L 5.02 0 -0.15 0.71855 TargetScan -0.29 0 NA
103 hsa-miR-141-3p FTO 5.02 0 -0.52 0.0001 mirMAP -0.1 0 NA
104 hsa-miR-141-3p FYCO1 5.02 0 -1.62 0 mirMAP -0.12 0 NA
105 hsa-miR-141-3p FZD4 5.02 0 -0.83 0.00068 TargetScan -0.11 0 NA
106 hsa-miR-141-3p GAB2 5.02 0 -1.2 0 mirMAP -0.13 0 NA
107 hsa-miR-141-3p GATA6 5.02 0 -3.38 0 TargetScan; miRNATAP -0.51 0 NA
108 hsa-miR-141-3p GCNT2 5.02 0 -0.71 0.08266 TargetScan -0.11 0.00337 NA
109 hsa-miR-141-3p GDF6 5.02 0 -1.14 0.02791 TargetScan -0.34 0 NA
110 hsa-miR-141-3p GEM 5.02 0 -3.69 0 MirTarget -0.59 0 NA
111 hsa-miR-141-3p GFRA1 5.02 0 -5 0 mirMAP -0.39 0 NA
112 hsa-miR-141-3p GFRA2 5.02 0 -3.22 0 mirMAP -0.44 0 NA
113 hsa-miR-141-3p GJC1 5.02 0 -0.97 0.00222 MirTarget; TargetScan; miRNATAP -0.25 0 NA
114 hsa-miR-141-3p GLI2 5.02 0 -2.29 0 MirTarget -0.49 0 NA
115 hsa-miR-141-3p GLRX 5.02 0 -0.28 0.31677 MirTarget; TargetScan; miRNATAP -0.13 0 NA
116 hsa-miR-141-3p GNA12 5.02 0 -0.33 0.08399 mirMAP -0.16 0 NA
117 hsa-miR-141-3p GNE 5.02 0 -0.89 0.00299 MirTarget -0.13 0 NA
118 hsa-miR-141-3p GNG4 5.02 0 0.22 0.74468 mirMAP -0.31 0 NA
119 hsa-miR-141-3p GNG7 5.02 0 -3.48 0 MirTarget; TargetScan; miRNATAP -0.3 0 NA
120 hsa-miR-141-3p GPC6 5.02 0 -2.71 0 TargetScan -0.64 0 NA
121 hsa-miR-141-3p GPD1 5.02 0 -1.45 0.00526 TargetScan -0.19 6.0E-5 NA
122 hsa-miR-141-3p GPM6B 5.02 0 -2.39 0 TargetScan; miRNATAP -0.3 0 NA
123 hsa-miR-141-3p GPR174 5.02 0 -0.71 0.15454 TargetScan -0.28 0 NA
124 hsa-miR-141-3p GPR63 5.02 0 -0.92 0.01437 TargetScan -0.15 1.0E-5 NA
125 hsa-miR-141-3p GPRC5B 5.02 0 -0.92 0.00843 mirMAP -0.17 0 NA
126 hsa-miR-141-3p GRAP2 5.02 0 -1.99 0 mirMAP -0.34 0 NA
127 hsa-miR-141-3p GRIK3 5.02 0 -4.42 0 mirMAP -0.34 0 NA
128 hsa-miR-141-3p GRIN3A 5.02 0 -0.24 0.40319 TargetScan; miRNATAP -0.19 0 NA
129 hsa-miR-141-3p GSN 5.02 0 -2.39 0 MirTarget -0.26 0 NA
130 hsa-miR-141-3p HAS2 5.02 0 -1.45 0.00631 MirTarget -0.37 0 NA
131 hsa-miR-141-3p HDAC4 5.02 0 -1.8 0 TargetScan; miRNATAP -0.22 0 NA
132 hsa-miR-141-3p HECW1 5.02 0 0.08 0.87699 TargetScan -0.23 0 NA
133 hsa-miR-141-3p HEYL 5.02 0 -0.31 0.27592 mirMAP -0.21 0 NA
134 hsa-miR-141-3p HGF 5.02 0 -2.97 0 MirTarget; TargetScan -0.68 0 NA
135 hsa-miR-141-3p HIPK3 5.02 0 -1.75 0 MirTarget; TargetScan -0.22 0 NA
136 hsa-miR-141-3p HIVEP3 5.02 0 0.03 0.92033 mirMAP -0.17 0 NA
137 hsa-miR-141-3p HLF 5.02 0 -5.48 0 TargetScan -0.59 0 NA
138 hsa-miR-141-3p HOXA11 5.02 0 -0.78 0.02922 TargetScan; miRNATAP -0.12 0.00017 NA
139 hsa-miR-141-3p HS3ST3B1 5.02 0 -0.64 0.18337 mirMAP -0.38 0 NA
140 hsa-miR-141-3p HSPA13 5.02 0 -0.29 0.10635 TargetScan -0.13 0 NA
141 hsa-miR-141-3p IFFO2 5.02 0 -0.91 0.00201 MirTarget; TargetScan -0.1 0.00019 NA
142 hsa-miR-141-3p IGDCC4 5.02 0 -1.99 0 TargetScan; miRNATAP -0.35 0 NA
143 hsa-miR-141-3p IGF2BP2 5.02 0 0.95 0.14454 MirTarget; TargetScan; miRNATAP -0.31 0 NA
144 hsa-miR-141-3p IGSF6 5.02 0 0.29 0.48351 TargetScan -0.26 0 NA
145 hsa-miR-141-3p IGSF9B 5.02 0 -3.7 0 TargetScan -0.38 0 NA
146 hsa-miR-141-3p IL18R1 5.02 0 -0.49 0.12464 MirTarget -0.13 1.0E-5 NA
147 hsa-miR-141-3p IL6R 5.02 0 -1.87 0 MirTarget -0.24 0 NA
148 hsa-miR-141-3p IRAK3 5.02 0 -1.61 0 mirMAP -0.24 0 NA
149 hsa-miR-141-3p IRS2 5.02 0 -0.91 0.01102 MirTarget; TargetScan; miRNATAP -0.16 0 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2
150 hsa-miR-141-3p ITGAV 5.02 0 -0.06 0.79571 MirTarget -0.13 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 77 1426 6.022e-17 2.802e-13
2 REGULATION OF CELL DIFFERENTIATION 75 1492 7.616e-15 1.191e-11
3 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 41 513 1.024e-14 1.191e-11
4 NEUROGENESIS 72 1402 1.004e-14 1.191e-11
5 CARDIOVASCULAR SYSTEM DEVELOPMENT 49 788 3.551e-13 2.754e-10
6 CIRCULATORY SYSTEM DEVELOPMENT 49 788 3.551e-13 2.754e-10
7 CELLULAR COMPONENT MORPHOGENESIS 52 900 1.076e-12 7.15e-10
8 POSITIVE REGULATION OF CELL DIFFERENTIATION 49 823 1.756e-12 1.021e-09
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 74 1672 6.801e-12 3.062e-09
10 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 66 1395 6.552e-12 3.062e-09
11 VASCULATURE DEVELOPMENT 35 469 7.24e-12 3.062e-09
12 TISSUE DEVELOPMENT 69 1518 1.233e-11 4.782e-09
13 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 60 1275 8.665e-11 2.88e-08
14 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 56 1142 8.635e-11 2.88e-08
15 BLOOD VESSEL MORPHOGENESIS 29 364 1.051e-10 3.057e-08
16 REGULATION OF CELLULAR COMPONENT MOVEMENT 44 771 1.043e-10 3.057e-08
17 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 51 1021 3.521e-10 9.637e-08
18 REGULATION OF NEURON DIFFERENTIATION 35 554 6.911e-10 1.692e-07
19 POSITIVE REGULATION OF CELL DEVELOPMENT 32 472 6.819e-10 1.692e-07
20 REGULATION OF CELL PROJECTION ORGANIZATION 35 558 8.36e-10 1.945e-07
21 POSITIVE REGULATION OF NEURON DIFFERENTIATION 25 306 1.261e-09 2.795e-07
22 REGULATION OF CELL DEVELOPMENT 44 836 1.323e-09 2.798e-07
23 POSITIVE REGULATION OF GENE EXPRESSION 70 1733 1.549e-09 3.133e-07
24 REGULATION OF CELL MORPHOGENESIS 34 552 2.349e-09 4.554e-07
25 LOCOMOTION 52 1114 2.45e-09 4.56e-07
26 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 27 368 2.869e-09 5.134e-07
27 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 47 957 3.203e-09 5.519e-07
28 NEURON PROJECTION MORPHOGENESIS 28 402 4.586e-09 7.621e-07
29 CENTRAL NERVOUS SYSTEM DEVELOPMENT 44 872 4.766e-09 7.648e-07
30 NEURON DIFFERENTIATION 44 874 5.106e-09 7.919e-07
31 NEURON PROJECTION DEVELOPMENT 33 545 6.222e-09 9.225e-07
32 REGULATION OF NEURON PROJECTION DEVELOPMENT 28 408 6.344e-09 9.225e-07
33 ANGIOGENESIS 23 293 1.25e-08 1.762e-06
34 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 39 750 1.708e-08 2.337e-06
35 BIOLOGICAL ADHESION 47 1032 3.316e-08 4.408e-06
36 NEURON DEVELOPMENT 36 687 5.178e-08 6.511e-06
37 POSITIVE REGULATION OF CELL PROLIFERATION 40 814 5.172e-08 6.511e-06
38 MUSCLE STRUCTURE DEVELOPMENT 27 432 8.254e-08 1.011e-05
39 MUSCLE TISSUE DEVELOPMENT 21 275 8.69e-08 1.037e-05
40 NEURON PROJECTION GUIDANCE 18 205 9.139e-08 1.063e-05
41 CELL PROJECTION ORGANIZATION 42 902 1.043e-07 1.184e-05
42 HEART DEVELOPMENT 28 466 1.074e-07 1.19e-05
43 STEM CELL DIFFERENTIATION 17 190 1.59e-07 1.72e-05
44 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 23 337 1.629e-07 1.723e-05
45 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 35 689 1.695e-07 1.753e-05
46 HEAD DEVELOPMENT 35 709 3.339e-07 3.378e-05
47 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 26 437 3.74e-07 3.702e-05
48 REGULATION OF EXTENT OF CELL GROWTH 12 101 5.273e-07 5.112e-05
49 EMBRYONIC MORPHOGENESIS 29 539 6.368e-07 6.047e-05
50 CELL PART MORPHOGENESIS 32 633 6.52e-07 6.068e-05
51 MESENCHYME DEVELOPMENT 16 190 8.349e-07 7.617e-05
52 CONNECTIVE TISSUE DEVELOPMENT 16 194 1.102e-06 9.805e-05
53 SENSORY ORGAN DEVELOPMENT 27 493 1.117e-06 9.805e-05
54 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 34 724 1.524e-06 0.0001313
55 REGULATION OF CELL ADHESION 31 629 1.67e-06 0.0001413
56 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 42 1004 1.763e-06 0.0001442
57 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 20 303 1.767e-06 0.0001442
58 MESENCHYMAL CELL DIFFERENTIATION 13 134 1.859e-06 0.0001491
59 POSITIVE REGULATION OF LOCOMOTION 24 420 2.146e-06 0.0001665
60 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 63 1805 2.127e-06 0.0001665
61 REGULATION OF CHONDROCYTE DIFFERENTIATION 8 46 2.322e-06 0.0001772
62 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 17 232 2.619e-06 0.0001965
63 REGULATION OF CARTILAGE DEVELOPMENT 9 63 2.996e-06 0.0002145
64 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 162 2.991e-06 0.0002145
65 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 62 1784 2.989e-06 0.0002145
66 TAXIS 25 464 3.747e-06 0.0002641
67 EMBRYO DEVELOPMENT 38 894 3.917e-06 0.000272
68 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 26 498 4.23e-06 0.0002894
69 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 8 50 4.47e-06 0.0003014
70 RESPONSE TO WOUNDING 28 563 4.544e-06 0.000302
71 GROWTH 23 410 4.757e-06 0.0003117
72 EYE DEVELOPMENT 20 326 5.354e-06 0.0003413
73 REGULATION OF PHOSPHORUS METABOLIC PROCESS 57 1618 5.32e-06 0.0003413
74 ORGAN MORPHOGENESIS 36 841 6.105e-06 0.0003839
75 SKELETAL SYSTEM DEVELOPMENT 24 455 8.38e-06 0.0005199
76 NEURON MIGRATION 11 110 8.614e-06 0.0005274
77 REGULATION OF ACTIN FILAMENT BASED PROCESS 19 312 1.021e-05 0.0006169
78 NEGATIVE REGULATION OF CELL COMMUNICATION 45 1192 1.075e-05 0.000641
79 REGULATION OF DEVELOPMENTAL GROWTH 18 289 1.287e-05 0.0007429
80 CELL MOTILITY 35 835 1.293e-05 0.0007429
81 LOCALIZATION OF CELL 35 835 1.293e-05 0.0007429
82 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 49 1360 1.469e-05 0.0008335
83 STEM CELL DIVISION 6 29 1.552e-05 0.0008594
84 CARDIOCYTE DIFFERENTIATION 10 96 1.54e-05 0.0008594
85 VASCULOGENESIS 8 59 1.589e-05 0.0008698
86 CARDIAC MUSCLE TISSUE DEVELOPMENT 12 140 1.652e-05 0.0008938
87 REGULATION OF EPITHELIAL CELL MIGRATION 13 166 1.954e-05 0.001044
88 INTRACELLULAR SIGNAL TRANSDUCTION 54 1572 1.974e-05 0.001044
89 MEMBRANE DEPOLARIZATION 8 61 2.041e-05 0.001067
90 REGULATION OF AXONOGENESIS 13 168 2.219e-05 0.001147
91 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 5 19 2.338e-05 0.001196
92 MULTICELLULAR ORGANISMAL SIGNALING 11 123 2.495e-05 0.001262
93 DEVELOPMENTAL GROWTH 19 333 2.532e-05 0.001267
94 MUSCLE ORGAN DEVELOPMENT 17 277 2.698e-05 0.001335
95 REGULATION OF CELL SIZE 13 172 2.845e-05 0.001393
96 REGULATION OF CELLULAR COMPONENT SIZE 19 337 2.982e-05 0.001445
97 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 6 33 3.391e-05 0.001627
98 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 60 1848 3.45e-05 0.001638
99 REGULATION OF MEMBRANE POTENTIAL 19 343 3.791e-05 0.001782
100 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 437 4.035e-05 0.001878
101 REGULATION OF CELL PROLIFERATION 51 1496 4.201e-05 0.001935
102 NEGATIVE REGULATION OF CELL DIFFERENTIATION 27 609 5.083e-05 0.002319
103 TUBE MORPHOGENESIS 18 323 5.596e-05 0.002528
104 HEART MORPHOGENESIS 14 212 6.274e-05 0.002807
105 REGULATION OF STEM CELL DIFFERENTIATION 10 113 6.358e-05 0.002817
106 FOREBRAIN DEVELOPMENT 19 357 6.486e-05 0.002847
107 HINDBRAIN DEVELOPMENT 11 137 6.755e-05 0.00291
108 SKELETAL MUSCLE ORGAN DEVELOPMENT 11 137 6.755e-05 0.00291
109 TUBE DEVELOPMENT 25 552 6.883e-05 0.002938
110 PROTEIN PHOSPHORYLATION 36 944 7.029e-05 0.002959
111 NEGATIVE REGULATION OF PHOSPHORYLATION 21 422 7.106e-05 0.002959
112 REGULATION OF ORGAN MORPHOGENESIS 15 242 7.122e-05 0.002959
113 ACTIN FILAMENT BASED MOVEMENT 9 93 7.353e-05 0.003028
114 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 32 801 7.656e-05 0.003125
115 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 5 24 7.899e-05 0.003196
116 SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE 4 13 8.255e-05 0.003311
117 CARDIAC MUSCLE CELL DIFFERENTIATION 8 74 8.415e-05 0.003347
118 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 6 39 9.067e-05 0.003575
119 EPITHELIAL TO MESENCHYMAL TRANSITION 7 56 9.245e-05 0.003585
120 OUTFLOW TRACT MORPHOGENESIS 7 56 9.245e-05 0.003585
121 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 38 1036 9.928e-05 0.003728
122 MEMBRANE ASSEMBLY 5 25 9.72e-05 0.003728
123 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 38 1036 9.928e-05 0.003728
124 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 30 740 9.934e-05 0.003728
125 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 4 14 0.0001138 0.004203
126 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 4 14 0.0001138 0.004203
127 CELL CELL ADHESION 26 608 0.0001253 0.004591
128 CARTILAGE DEVELOPMENT 11 147 0.0001273 0.004628
129 METENCEPHALON DEVELOPMENT 9 100 0.0001293 0.004665
130 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 24 541 0.0001315 0.00467
131 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 24 541 0.0001315 0.00467
132 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 103 0.0001623 0.00572
133 ACTIN FILAMENT BASED PROCESS 21 450 0.0001737 0.006075
134 REGULATION OF FAT CELL DIFFERENTIATION 9 106 0.0002019 0.006878
135 CARDIAC MUSCLE CELL CONTRACTION 5 29 0.000204 0.006878
136 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 5 29 0.000204 0.006878
137 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 4 16 0.0002008 0.006878
138 MUSCLE CELL DIFFERENTIATION 14 237 0.0002038 0.006878
139 BONE DEVELOPMENT 11 156 0.0002149 0.007195
140 AMINOGLYCAN BIOSYNTHETIC PROCESS 9 107 0.0002168 0.007206
141 CARDIAC SEPTUM DEVELOPMENT 8 85 0.0002239 0.007389
142 MEMBRANE BIOGENESIS 5 30 0.000241 0.007897
143 EPITHELIAL CELL DIFFERENTIATION 22 495 0.0002429 0.007902
144 CELL JUNCTION ORGANIZATION 12 185 0.000245 0.007916
145 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 36 1008 0.0002542 0.008158
146 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 52 1656 0.0002774 0.008723
147 RESPONSE TO ENDOGENOUS STIMULUS 47 1450 0.0002769 0.008723
148 EXTRACELLULAR STRUCTURE ORGANIZATION 16 304 0.0002743 0.008723
149 DIGESTIVE TRACT MORPHOGENESIS 6 48 0.000295 0.009213
150 REGULATION OF ANATOMICAL STRUCTURE SIZE 21 472 0.00033 0.009996
151 GLOMERULUS DEVELOPMENT 6 49 0.0003308 0.009996
152 REGULATION OF ACTIN CYTOSKELETON REORGANIZATION 5 32 0.00033 0.009996
153 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 35 983 0.000328 0.009996
154 ADIPOSE TISSUE DEVELOPMENT 5 32 0.00033 0.009996
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 36 629 5.434e-09 5.048e-06
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 51 1199 7.263e-08 3.374e-05
3 CYTOSKELETAL PROTEIN BINDING 37 819 1.295e-06 0.0003007
4 REGULATORY REGION NUCLEIC ACID BINDING 37 818 1.258e-06 0.0003007
5 SEQUENCE SPECIFIC DNA BINDING 42 1037 3.97e-06 0.0007377
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 20 328 5.865e-06 0.0009081
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 18 315 4.043e-05 0.004695
8 SEMAPHORIN RECEPTOR ACTIVITY 4 11 3.928e-05 0.004695
9 ACTIN BINDING 20 393 7.767e-05 0.008018
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 60 1151 1.302e-12 7.603e-10
2 CELL PROJECTION 74 1786 1.491e-10 4.352e-08
3 SYNAPSE 42 754 5.996e-10 1.167e-07
4 NEURON PART 54 1265 2.527e-08 3.69e-06
5 NEURON PROJECTION 42 942 3.36e-07 3.925e-05
6 CELL LEADING EDGE 22 350 1.216e-06 0.0001183
7 CYTOSKELETON 65 1967 8.748e-06 0.0007298
8 SITE OF POLARIZED GROWTH 12 149 3.082e-05 0.00191
9 CELL SUBSTRATE JUNCTION 21 398 3.06e-05 0.00191
10 CELL PROJECTION PART 37 946 3.271e-05 0.00191
11 SEMAPHORIN RECEPTOR COMPLEX 4 11 3.928e-05 0.002085
12 ACTIN CYTOSKELETON 22 444 5.11e-05 0.002273
13 CELL CELL JUNCTION 20 383 5.449e-05 0.002273
14 MICROTUBULE END 5 22 5.051e-05 0.002273
15 ANCHORING JUNCTION 23 489 7.644e-05 0.002976
16 LAMELLIPODIUM 12 172 0.000124 0.004526
17 SIDE OF MEMBRANE 20 428 0.0002425 0.008331
18 MICROTUBULE PLUS END 4 17 0.0002586 0.00839
19 MEMBRANE REGION 39 1134 0.0002999 0.009217
20 SYNAPSE PART 25 610 0.0003205 0.00936

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_adhesion_molecules_.CAMs._hsa04514 12 145 2.351e-05 0.001222
2 Hippo_signaling_pathway_multiple_species_hsa04392 5 29 0.000204 0.005304
3 Hippo_signaling_pathway_hsa04390 10 154 0.0007874 0.01365
4 Ras_signaling_pathway_hsa04014 11 232 0.005295 0.0623
5 Rap1_signaling_pathway_hsa04015 10 206 0.006539 0.0623
6 Wnt_signaling_pathway_hsa04310 8 146 0.007189 0.0623
7 MAPK_signaling_pathway_hsa04010 12 295 0.01182 0.08029
8 Hedgehog_signaling_pathway_hsa04340 4 47 0.01235 0.08029
9 Apelin_signaling_pathway_hsa04371 7 137 0.01651 0.09538
10 Jak_STAT_signaling_pathway_hsa04630 7 162 0.03674 0.1867
11 PI3K_Akt_signaling_pathway_hsa04151 12 352 0.03949 0.1867
12 TNF_signaling_pathway_hsa04668 5 108 0.05671 0.2458
13 TGF_beta_signaling_pathway_hsa04350 4 84 0.07772 0.2986
14 ErbB_signaling_pathway_hsa04012 4 85 0.08039 0.2986
15 Cell_cycle_hsa04110 5 124 0.09014 0.3125
16 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.1058 0.3333
17 Tight_junction_hsa04530 6 170 0.109 0.3333
18 Cytokine_cytokine_receptor_interaction_hsa04060 8 270 0.1484 0.4287
19 cAMP_signaling_pathway_hsa04024 6 198 0.1806 0.4769
20 Focal_adhesion_hsa04510 6 199 0.1834 0.4769
21 Cellular_senescence_hsa04218 5 160 0.1934 0.4783
22 AMPK_signaling_pathway_hsa04152 4 121 0.2023 0.4783
23 Autophagy_animal_hsa04140 4 128 0.2305 0.5138
24 Gap_junction_hsa04540 3 88 0.2379 0.5138
25 FoxO_signaling_pathway_hsa04068 4 132 0.247 0.5138
26 Calcium_signaling_pathway_hsa04020 5 182 0.2704 0.5407
27 Phospholipase_D_signaling_pathway_hsa04072 4 146 0.3065 0.5903
28 p53_signaling_pathway_hsa04115 2 68 0.3752 0.6538
29 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.3803 0.6538
30 Necroptosis_hsa04217 4 164 0.3846 0.6538
31 Sphingolipid_signaling_pathway_hsa04071 3 118 0.3941 0.6538
32 Adherens_junction_hsa04520 2 72 0.4023 0.6538
33 ECM_receptor_interaction_hsa04512 2 82 0.4676 0.7368
34 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.5458 0.8244
35 mTOR_signaling_pathway_hsa04150 3 151 0.5549 0.8244
36 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.618 0.8685
37 Lysosome_hsa04142 2 123 0.6856 0.9198
38 Oocyte_meiosis_hsa04114 2 124 0.6899 0.9198
39 Apoptosis_hsa04210 2 138 0.7448 0.9266
40 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.7484 0.9266
41 Phagosome_hsa04145 2 152 0.7912 0.9568
42 Endocytosis_hsa04144 2 244 0.9495 1

Quest ID: eef48273572a7d30037c16f6cc5ed1b7