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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-3p BMI1 0.01 0.90222 0.32 0.00051 miRNAWalker2 validate -0.13 1.0E-5 NA
2 hsa-miR-15a-5p BMI1 0.81 0 0.32 0.00051 miRNAWalker2 validate; miRTarBase -0.11 0.00226 27596816 Our results suggest that overexpression of miR-15a and miR-16 mediates down-regulation of BMI1 and leads to mitochondrial mediated apoptosis
3 hsa-miR-218-5p BMI1 -1.03 0 0.32 0.00051 miRNAWalker2 validate; miRNATAP -0.15 0 25999024; 24839010; 23255074 Western blot analysis and luciferase reporter assay revealed that miR-218 decreased BMI1 expression by binding to the putative binding sites in its 3'-untranslated region 3'-UTR; The BMI1 mRNA expression levels were markedly increased and negatively correlated with the miR-218 expression level in the ESCC tissues; The knockdown of BMI1 by siRNA showed the same phenocopy as the effect of miR-218 on ESCC cells indicating that BMI1 was a major target of miR-218; In the present study our findings confirm miR-218 as a tumor suppressor and identify BMI1 as a novel target of miR-218 in ESCC;We then used the Dual-Luciferase assay system quantitative real-time RT-PCR qRT-PCR and Western blot analysis to determine that miR-218 targeted the 3'-UTR of the oncogenes CIP2A and BMI1 and thus regulated the biological process of melanoma; We further demonstrated that CIP2A and BMI1 knockdown phenocopies miR-218 overexpression; By targeting CIP2A and BMI1 miR-218 regulates the proliferation migration and invasion of the melanoma cell lines A375 and SK-MEL-2 indicating that miR-218 plays a pivotal role in melanoma development;Potential target genes of miR-218 were predicted and BMI1 polycomb ring finger oncogene BMI-1 a polycomb ring finger oncogene was identified as one of the potential targets
4 hsa-miR-27a-3p BMI1 0.39 1.0E-5 0.32 0.00051 miRNAWalker2 validate -0.21 0 NA
5 hsa-miR-455-5p BMI1 0.28 0.03576 0.32 0.00051 miRanda -0.18 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 76 1518 1.948e-24 4.532e-21
2 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 83 1784 9.996e-25 4.532e-21
3 REGULATION OF CELL PROLIFERATION 75 1496 3.956e-24 6.135e-21
4 POSITIVE REGULATION OF GENE EXPRESSION 80 1733 1.546e-23 1.799e-20
5 EPITHELIUM DEVELOPMENT 57 945 6.094e-22 5.671e-19
6 NEGATIVE REGULATION OF GENE EXPRESSION 70 1493 8.671e-21 6.725e-18
7 ORGAN MORPHOGENESIS 51 841 1.007e-19 6.697e-17
8 REGULATION OF CELL CYCLE 54 949 1.254e-19 7.295e-17
9 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 75 1805 2.804e-19 1.45e-16
10 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 46 740 3.115e-18 1.45e-15
11 CELL DEVELOPMENT 64 1426 5.507e-18 2.329e-15
12 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 53 1004 7.665e-18 2.972e-15
13 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 65 1517 2.913e-17 1.043e-14
14 TISSUE MORPHOGENESIS 38 533 4.15e-17 1.379e-14
15 MORPHOGENESIS OF AN EPITHELIUM 33 400 8.072e-17 2.504e-14
16 TUBE MORPHOGENESIS 30 323 8.816e-17 2.564e-14
17 REGULATION OF PROTEIN MODIFICATION PROCESS 68 1710 2.049e-16 5.609e-14
18 TUBE DEVELOPMENT 37 552 8.087e-16 2.091e-13
19 EMBRYO DEVELOPMENT 47 894 8.757e-16 2.145e-13
20 EMBRYONIC MORPHOGENESIS 36 539 2.299e-15 5.349e-13
21 POSITIVE REGULATION OF CELL PROLIFERATION 44 814 3.071e-15 6.805e-13
22 NEUROGENESIS 58 1402 1.04e-14 2.2e-12
23 REGULATION OF CELL DIFFERENTIATION 60 1492 1.149e-14 2.325e-12
24 CHROMOSOME ORGANIZATION 48 1009 1.887e-14 3.659e-12
25 GLAND DEVELOPMENT 30 395 2.042e-14 3.8e-12
26 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 35 554 3.058e-14 5.473e-12
27 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 42 801 3.997e-14 6.888e-12
28 CELL FATE COMMITMENT 23 227 6.322e-14 1.051e-11
29 PATTERN SPECIFICATION PROCESS 30 418 9.051e-14 1.452e-11
30 NEGATIVE REGULATION OF CELL DIFFERENTIATION 36 609 9.449e-14 1.465e-11
31 POSITIVE REGULATION OF RESPONSE TO STIMULUS 67 1929 2.567e-13 3.852e-11
32 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 49 1142 4.72e-13 6.863e-11
33 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 61 1672 4.933e-13 6.956e-11
34 REGULATION OF MUSCLE ORGAN DEVELOPMENT 16 103 6.133e-13 8.393e-11
35 REGULATION OF BINDING 24 283 8.882e-13 1.181e-10
36 REGIONALIZATION 25 311 9.667e-13 1.25e-10
37 REGULATION OF EPITHELIAL CELL PROLIFERATION 24 285 1.034e-12 1.301e-10
38 CELLULAR RESPONSE TO STRESS 58 1565 1.116e-12 1.366e-10
39 CHROMATIN ORGANIZATION 36 663 1.165e-12 1.39e-10
40 EMBRYONIC ORGAN DEVELOPMENT 28 406 1.677e-12 1.951e-10
41 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 56 1492 1.807e-12 2.051e-10
42 CELL CYCLE 52 1316 1.922e-12 2.129e-10
43 ANTERIOR POSTERIOR PATTERN SPECIFICATION 20 194 2.088e-12 2.259e-10
44 CHROMATIN MODIFICATION 32 539 2.239e-12 2.368e-10
45 INTERSPECIES INTERACTION BETWEEN ORGANISMS 35 662 5.248e-12 5.309e-10
46 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 35 662 5.248e-12 5.309e-10
47 SENSORY ORGAN DEVELOPMENT 30 493 6.196e-12 6.134e-10
48 REGULATION OF MUSCLE TISSUE DEVELOPMENT 15 103 8.637e-12 8.373e-10
49 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 42 957 1.376e-11 1.307e-09
50 REGULATION OF ORGAN MORPHOGENESIS 21 242 1.612e-11 1.5e-09
51 POSITIVE REGULATION OF CELL COMMUNICATION 55 1532 1.689e-11 1.531e-09
52 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 52 1395 1.712e-11 1.531e-09
53 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 46 1135 1.938e-11 1.702e-09
54 SKELETAL SYSTEM DEVELOPMENT 28 455 2.524e-11 2.175e-09
55 RESPONSE TO ABIOTIC STIMULUS 43 1024 3.154e-11 2.668e-09
56 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 42 983 3.211e-11 2.668e-09
57 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 17 154 3.296e-11 2.69e-09
58 POSITIVE REGULATION OF CELL DIFFERENTIATION 38 823 3.358e-11 2.694e-09
59 CELL PROLIFERATION 34 672 3.581e-11 2.824e-09
60 REGULATION OF CELL DEATH 53 1472 3.84e-11 2.978e-09
61 REGULATION OF WNT SIGNALING PATHWAY 23 310 4.158e-11 3.171e-09
62 CENTRAL NERVOUS SYSTEM DEVELOPMENT 39 872 4.639e-11 3.482e-09
63 CELL CYCLE PROCESS 44 1081 4.955e-11 3.602e-09
64 NEGATIVE REGULATION OF CELL PROLIFERATION 33 643 4.916e-11 3.602e-09
65 COVALENT CHROMATIN MODIFICATION 24 345 5.9e-11 4.223e-09
66 REGULATION OF FIBROBLAST PROLIFERATION 13 81 6.145e-11 4.332e-09
67 PEPTIDYL AMINO ACID MODIFICATION 38 841 6.301e-11 4.376e-09
68 MITOTIC CELL CYCLE 36 766 7.159e-11 4.898e-09
69 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 32 616 7.266e-11 4.899e-09
70 IMMUNE SYSTEM DEVELOPMENT 31 582 7.921e-11 5.265e-09
71 REGULATION OF HEART MORPHOGENESIS 9 29 1.031e-10 6.758e-09
72 MORPHOGENESIS OF A BRANCHING STRUCTURE 17 167 1.203e-10 7.776e-09
73 REGULATION OF TRANSFERASE ACTIVITY 40 946 1.374e-10 8.755e-09
74 NEURON DIFFERENTIATION 38 874 1.906e-10 1.199e-08
75 REGULATION OF CELL DEVELOPMENT 37 836 2.07e-10 1.284e-08
76 REGULATION OF RESPONSE TO STRESS 51 1468 3.424e-10 2.096e-08
77 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 28 513 4.007e-10 2.401e-08
78 REGULATION OF PHOSPHORUS METABOLIC PROCESS 54 1618 4.024e-10 2.401e-08
79 RESPONSE TO EXTERNAL STIMULUS 58 1821 4.671e-10 2.751e-08
80 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 19 236 5.524e-10 3.213e-08
81 IMMUNE SYSTEM PROCESS 61 1984 5.962e-10 3.386e-08
82 REGULATION OF CELL CYCLE PROCESS 29 558 5.968e-10 3.386e-08
83 HEAD DEVELOPMENT 33 709 6.115e-10 3.428e-08
84 REGULATION OF GROWTH 31 633 6.24e-10 3.456e-08
85 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 42 1087 7.086e-10 3.879e-08
86 RESPONSE TO WOUNDING 29 563 7.331e-10 3.966e-08
87 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 58 1848 8.17e-10 4.369e-08
88 EPITHELIAL CELL DIFFERENTIATION 27 495 8.517e-10 4.503e-08
89 CELL ACTIVATION 29 568 8.984e-10 4.645e-08
90 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 9 36 8.925e-10 4.645e-08
91 POSITIVE REGULATION OF CELL CYCLE 22 332 9.596e-10 4.906e-08
92 RESPONSE TO LIPID 37 888 1.096e-09 5.545e-08
93 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 40 1021 1.282e-09 6.412e-08
94 REGULATION OF CHROMOSOME ORGANIZATION 20 278 1.387e-09 6.865e-08
95 LOCOMOTION 42 1114 1.476e-09 7.228e-08
96 REGULATION OF DNA METABOLIC PROCESS 22 340 1.497e-09 7.256e-08
97 PEPTIDYL LYSINE MODIFICATION 21 312 1.77e-09 8.49e-08
98 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 10 53 1.992e-09 9.456e-08
99 RESPONSE TO ORGANIC CYCLIC COMPOUND 37 917 2.619e-09 1.231e-07
100 NEGATIVE REGULATION OF PHOSPHORYLATION 24 422 3.432e-09 1.597e-07
101 AGING 19 264 3.598e-09 1.658e-07
102 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 724 4.005e-09 1.827e-07
103 RESPONSE TO ALCOHOL 22 362 4.765e-09 2.153e-07
104 REGULATION OF CELLULAR RESPONSE TO STRESS 31 691 5.046e-09 2.258e-07
105 CELLULAR COMPONENT MORPHOGENESIS 36 900 5.522e-09 2.447e-07
106 NEGATIVE REGULATION OF CELL CYCLE 24 433 5.673e-09 2.49e-07
107 NEGATIVE REGULATION OF MOLECULAR FUNCTION 40 1079 6.156e-09 2.677e-07
108 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 46 1360 6.775e-09 2.919e-07
109 MESENCHYME DEVELOPMENT 16 190 6.901e-09 2.946e-07
110 GLAND MORPHOGENESIS 12 97 7.393e-09 3.099e-07
111 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 52 1656 7.375e-09 3.099e-07
112 CELL DEATH 38 1001 8.206e-09 3.409e-07
113 EMBRYONIC ORGAN MORPHOGENESIS 19 279 8.903e-09 3.666e-07
114 REGULATION OF PROTEIN BINDING 15 168 9.321e-09 3.771e-07
115 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 32 750 9.312e-09 3.771e-07
116 IN UTERO EMBRYONIC DEVELOPMENT 20 311 9.479e-09 3.802e-07
117 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 16 197 1.159e-08 4.609e-07
118 DNA METABOLIC PROCESS 32 758 1.197e-08 4.721e-07
119 ENDOCRINE SYSTEM DEVELOPMENT 13 123 1.215e-08 4.751e-07
120 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 41 1152 1.236e-08 4.791e-07
121 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 9 48 1.38e-08 5.307e-07
122 POSITIVE REGULATION OF CELL DEATH 28 605 1.517e-08 5.787e-07
123 OSTEOBLAST DIFFERENTIATION 13 126 1.63e-08 6.165e-07
124 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 12 104 1.649e-08 6.187e-07
125 REGULATION OF CHROMATIN ORGANIZATION 14 152 1.972e-08 7.34e-07
126 REGULATION OF KINASE ACTIVITY 32 776 2.079e-08 7.679e-07
127 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 13 129 2.168e-08 7.887e-07
128 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 8 36 2.17e-08 7.887e-07
129 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 28 616 2.228e-08 8.037e-07
130 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 541 2.407e-08 8.551e-07
131 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 26 541 2.407e-08 8.551e-07
132 REGULATION OF CELL CYCLE ARREST 12 108 2.536e-08 8.871e-07
133 REGULATION OF MITOTIC CELL CYCLE 24 468 2.528e-08 8.871e-07
134 REGULATION OF STEM CELL PROLIFERATION 11 88 2.828e-08 9.821e-07
135 DEVELOPMENTAL GROWTH 20 333 2.976e-08 1.026e-06
136 RESPONSE TO OXYGEN CONTAINING COMPOUND 45 1381 3.098e-08 1.06e-06
137 RESPONSE TO GROWTH FACTOR 24 475 3.349e-08 1.137e-06
138 POSITIVE REGULATION OF DNA METABOLIC PROCESS 15 185 3.428e-08 1.15e-06
139 CELL CYCLE G1 S PHASE TRANSITION 12 111 3.46e-08 1.15e-06
140 G1 S TRANSITION OF MITOTIC CELL CYCLE 12 111 3.46e-08 1.15e-06
141 RESPONSE TO EXTRACELLULAR STIMULUS 23 441 3.68e-08 1.214e-06
142 POSITIVE REGULATION OF MOLECULAR FUNCTION 53 1791 3.771e-08 1.236e-06
143 ENDODERM DEVELOPMENT 10 71 3.81e-08 1.237e-06
144 REGULATION OF OSTEOBLAST DIFFERENTIATION 12 112 3.829e-08 1.237e-06
145 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 6 16 4.094e-08 1.314e-06
146 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 14 162 4.438e-08 1.414e-06
147 GROWTH 22 410 4.473e-08 1.416e-06
148 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 16 218 4.842e-08 1.522e-06
149 RESPONSE TO OXYGEN LEVELS 19 311 5.09e-08 1.579e-06
150 REGULATION OF DNA BINDING 11 93 5.076e-08 1.579e-06
151 NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 40 5.263e-08 1.622e-06
152 REGULATION OF PROTEIN STABILITY 16 221 5.857e-08 1.793e-06
153 OSSIFICATION 17 251 5.952e-08 1.81e-06
154 REGULATION OF ORGANELLE ORGANIZATION 40 1178 6.818e-08 2.06e-06
155 EAR DEVELOPMENT 15 195 6.904e-08 2.072e-06
156 CELL CYCLE PHASE TRANSITION 17 255 7.488e-08 2.219e-06
157 CELLULAR RESPONSE TO OXYGEN LEVELS 13 143 7.452e-08 2.219e-06
158 NEGATIVE REGULATION OF CELL DEATH 33 872 9.37e-08 2.759e-06
159 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 23 465 9.617e-08 2.814e-06
160 LEUKOCYTE DIFFERENTIATION 18 292 1.009e-07 2.908e-06
161 CARDIOVASCULAR SYSTEM DEVELOPMENT 31 788 1.013e-07 2.908e-06
162 CIRCULATORY SYSTEM DEVELOPMENT 31 788 1.013e-07 2.908e-06
163 SKELETAL SYSTEM MORPHOGENESIS 15 201 1.029e-07 2.938e-06
164 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 33 876 1.042e-07 2.956e-06
165 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 17 262 1.107e-07 3.122e-06
166 DIGESTIVE SYSTEM DEVELOPMENT 13 148 1.119e-07 3.136e-06
167 MACROMOLECULE METHYLATION 15 205 1.333e-07 3.713e-06
168 UROGENITAL SYSTEM DEVELOPMENT 18 299 1.439e-07 3.985e-06
169 REGULATION OF NEURON DIFFERENTIATION 25 554 1.514e-07 4.168e-06
170 POSITIVE REGULATION OF PROTEIN IMPORT 11 104 1.629e-07 4.459e-06
171 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 29 720 1.652e-07 4.494e-06
172 NEGATIVE REGULATION OF CELL DEVELOPMENT 18 303 1.754e-07 4.745e-06
173 GASTRULATION 13 155 1.924e-07 5.175e-06
174 REGULATION OF FAT CELL DIFFERENTIATION 11 106 1.983e-07 5.302e-06
175 REGULATION OF PROTEIN IMPORT 14 183 2.034e-07 5.408e-06
176 NEURON DEVELOPMENT 28 687 2.154e-07 5.694e-06
177 NEGATIVE REGULATION OF BINDING 12 131 2.192e-07 5.729e-06
178 POSITIVE REGULATION OF CELL CYCLE ARREST 10 85 2.187e-07 5.729e-06
179 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 6 21 2.621e-07 6.814e-06
180 POSITIVE REGULATION OF CELL CYCLE PROCESS 16 247 2.696e-07 6.969e-06
181 FORMATION OF PRIMARY GERM LAYER 11 110 2.9e-07 7.454e-06
182 SINGLE ORGANISM CELL ADHESION 22 459 3.163e-07 8.085e-06
183 STEM CELL DIFFERENTIATION 14 190 3.225e-07 8.199e-06
184 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 15 220 3.329e-07 8.407e-06
185 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 19 351 3.343e-07 8.407e-06
186 CELLULAR RESPONSE TO RADIATION 12 137 3.575e-07 8.943e-06
187 NEGATIVE REGULATION OF OSSIFICATION 9 69 3.642e-07 9.063e-06
188 EPIDERMIS DEVELOPMENT 16 253 3.727e-07 9.225e-06
189 REGULATION OF STEM CELL DIFFERENTIATION 11 113 3.816e-07 9.393e-06
190 NOTCH SIGNALING PATHWAY 11 114 4.173e-07 1.022e-05
191 NEURON PROJECTION DEVELOPMENT 24 545 4.222e-07 1.029e-05
192 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 7 36 4.516e-07 1.095e-05
193 CELL FATE SPECIFICATION 9 71 4.675e-07 1.127e-05
194 WOUND HEALING 22 470 4.721e-07 1.132e-05
195 POSITIVE REGULATION OF CELL DEVELOPMENT 22 472 5.071e-07 1.21e-05
196 PLATELET ACTIVATION 12 142 5.272e-07 1.251e-05
197 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 40 1275 5.389e-07 1.273e-05
198 POSITIVE REGULATION OF PROTEOLYSIS 19 363 5.571e-07 1.309e-05
199 CELLULAR RESPONSE TO ABIOTIC STIMULUS 16 263 6.261e-07 1.464e-05
200 CELLULAR RESPONSE TO EXTERNAL STIMULUS 16 264 6.586e-07 1.532e-05
201 MESENCHYME MORPHOGENESIS 7 38 6.672e-07 1.545e-05
202 REGULATION OF CELLULAR COMPONENT MOVEMENT 29 771 6.774e-07 1.56e-05
203 CARDIOCYTE DIFFERENTIATION 10 96 6.922e-07 1.587e-05
204 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 11 121 7.619e-07 1.738e-05
205 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 27 689 7.707e-07 1.749e-05
206 GLIOGENESIS 13 175 7.795e-07 1.761e-05
207 REGULATION OF OSSIFICATION 13 178 9.454e-07 2.125e-05
208 SENSORY ORGAN MORPHOGENESIS 15 239 9.551e-07 2.137e-05
209 LYMPHOCYTE DIFFERENTIATION 14 209 1.021e-06 2.272e-05
210 LYMPHOCYTE ACTIVATION 18 342 1.029e-06 2.28e-05
211 DEVELOPMENTAL PROGRAMMED CELL DEATH 6 26 1.051e-06 2.317e-05
212 RESPONSE TO UV 11 126 1.142e-06 2.507e-05
213 CELLULAR RESPONSE TO LIPID 21 457 1.167e-06 2.549e-05
214 RESPONSE TO STEROID HORMONE 22 497 1.198e-06 2.605e-05
215 HEART MORPHOGENESIS 14 212 1.21e-06 2.618e-05
216 POSITIVE REGULATION OF LOCOMOTION 20 420 1.224e-06 2.637e-05
217 CELL CYCLE ARREST 12 154 1.256e-06 2.694e-05
218 AXIS ELONGATION 6 27 1.336e-06 2.851e-05
219 POSITIVE REGULATION OF STEM CELL PROLIFERATION 8 61 1.577e-06 3.351e-05
220 PROTEIN PHOSPHORYLATION 32 944 1.659e-06 3.509e-05
221 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 1.681e-06 3.539e-05
222 METHYLATION 16 284 1.722e-06 3.609e-05
223 VASCULATURE DEVELOPMENT 21 469 1.761e-06 3.675e-05
224 HAIR CYCLE 9 83 1.792e-06 3.706e-05
225 MOLTING CYCLE 9 83 1.792e-06 3.706e-05
226 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 21 470 1.821e-06 3.75e-05
227 REGULATION OF PROTEIN LOCALIZATION 32 950 1.898e-06 3.874e-05
228 REGULATION OF CELL CYCLE PHASE TRANSITION 17 321 1.898e-06 3.874e-05
229 NEGATIVE REGULATION OF CELL COMMUNICATION 37 1192 1.944e-06 3.95e-05
230 HISTONE METHYLATION 9 84 1.983e-06 4.013e-05
231 REGENERATION 12 161 2.009e-06 4.048e-05
232 MESENCHYMAL CELL DIFFERENTIATION 11 134 2.102e-06 4.215e-05
233 REGULATION OF DEVELOPMENTAL GROWTH 16 289 2.16e-06 4.296e-05
234 APOPTOTIC SIGNALING PATHWAY 16 289 2.16e-06 4.296e-05
235 PALATE DEVELOPMENT 9 85 2.192e-06 4.323e-05
236 POSITIVE REGULATION OF CHROMATIN MODIFICATION 9 85 2.192e-06 4.323e-05
237 EYE DEVELOPMENT 17 326 2.34e-06 4.594e-05
238 GLIAL CELL DIFFERENTIATION 11 136 2.431e-06 4.753e-05
239 REGULATION OF CYTOPLASMIC TRANSPORT 21 481 2.621e-06 5.102e-05
240 CELLULAR RESPONSE TO UV 8 66 2.902e-06 5.627e-05
241 REGULATION OF GENE EXPRESSION EPIGENETIC 14 229 3.003e-06 5.799e-05
242 MACROMOLECULE CATABOLIC PROCESS 31 926 3.157e-06 6.07e-05
243 APPENDAGE DEVELOPMENT 12 169 3.336e-06 6.362e-05
244 LIMB DEVELOPMENT 12 169 3.336e-06 6.362e-05
245 REGULATION OF EMBRYONIC DEVELOPMENT 10 114 3.376e-06 6.412e-05
246 DIGESTIVE TRACT MORPHOGENESIS 7 48 3.469e-06 6.562e-05
247 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 23 573 3.55e-06 6.687e-05
248 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 17 337 3.655e-06 6.857e-05
249 RESPONSE TO RADIATION 19 413 3.756e-06 7.02e-05
250 REGULATION OF CELLULAR LOCALIZATION 38 1277 3.772e-06 7.021e-05
251 REGULATION OF ORGAN FORMATION 6 32 3.864e-06 7.163e-05
252 LEUKOCYTE ACTIVATION 19 414 3.89e-06 7.183e-05
253 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 7 50 4.599e-06 8.348e-05
254 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 7 50 4.599e-06 8.348e-05
255 ENDODERM FORMATION 7 50 4.599e-06 8.348e-05
256 MESODERM DEVELOPMENT 10 118 4.611e-06 8.348e-05
257 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 11 145 4.539e-06 8.348e-05
258 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 9 93 4.663e-06 8.409e-05
259 REGULATION OF PROTEIN TARGETING 16 307 4.692e-06 8.429e-05
260 RESPONSE TO ENDOGENOUS STIMULUS 41 1450 5.255e-06 9.405e-05
261 HEMOSTASIS 16 311 5.53e-06 9.858e-05
262 CANONICAL WNT SIGNALING PATHWAY 9 95 5.564e-06 9.881e-05
263 NEURAL TUBE DEVELOPMENT 11 149 5.902e-06 0.0001044
264 WNT SIGNALING PATHWAY 17 351 6.273e-06 0.0001101
265 REGULATION OF ORGAN GROWTH 8 73 6.261e-06 0.0001101
266 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 11 150 6.294e-06 0.0001101
267 REGULATION OF CELLULAR PROTEIN LOCALIZATION 22 552 6.518e-06 0.0001132
268 REGULATION OF CELL MORPHOGENESIS 22 552 6.518e-06 0.0001132
269 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 9 97 6.61e-06 0.0001143
270 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 25 684 6.843e-06 0.0001179
271 RESPONSE TO DRUG 19 431 6.924e-06 0.0001189
272 MUSCLE STRUCTURE DEVELOPMENT 19 432 7.156e-06 0.0001215
273 INTRINSIC APOPTOTIC SIGNALING PATHWAY 11 152 7.147e-06 0.0001215
274 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 11 152 7.147e-06 0.0001215
275 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 15 282 7.309e-06 0.0001237
276 FOREBRAIN DEVELOPMENT 17 357 7.838e-06 0.0001321
277 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 23 602 7.963e-06 0.0001338
278 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 28 829 8.295e-06 0.0001388
279 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 17 360 8.744e-06 0.0001458
280 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 8 77 9.356e-06 0.0001547
281 ENDOCARDIAL CUSHION MORPHOGENESIS 5 22 9.428e-06 0.0001547
282 RNA PROCESSING 28 835 9.476e-06 0.0001547
283 CELL MOTILITY 28 835 9.476e-06 0.0001547
284 LOCALIZATION OF CELL 28 835 9.476e-06 0.0001547
285 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 5 22 9.428e-06 0.0001547
286 POSITIVE REGULATION OF KINASE ACTIVITY 20 482 9.667e-06 0.0001573
287 EPITHELIAL TO MESENCHYMAL TRANSITION 7 56 9.967e-06 0.0001588
288 CARDIAC CELL FATE COMMITMENT 4 11 9.949e-06 0.0001588
289 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 15 289 9.799e-06 0.0001588
290 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 56 9.967e-06 0.0001588
291 OUTFLOW TRACT MORPHOGENESIS 7 56 9.967e-06 0.0001588
292 PROSTATE GLANDULAR ACINUS DEVELOPMENT 4 11 9.949e-06 0.0001588
293 BLOOD VESSEL MORPHOGENESIS 17 364 1.01e-05 0.0001604
294 TUBE FORMATION 10 129 1.022e-05 0.0001617
295 SOMITE DEVELOPMENT 8 78 1.03e-05 0.0001625
296 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 17 365 1.047e-05 0.0001645
297 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 32 1036 1.132e-05 0.0001764
298 NEGATIVE REGULATION OF PROTEIN BINDING 8 79 1.133e-05 0.0001764
299 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 32 1036 1.132e-05 0.0001764
300 REGULATION OF MAPK CASCADE 24 660 1.145e-05 0.0001776
301 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 12 191 1.168e-05 0.0001806
302 PROSTATE GLAND MORPHOGENESIS 5 23 1.191e-05 0.0001836
303 REPRODUCTIVE SYSTEM DEVELOPMENT 18 408 1.2e-05 0.0001843
304 ASTROCYTE DIFFERENTIATION 6 39 1.285e-05 0.0001961
305 PLATELET AGGREGATION 6 39 1.285e-05 0.0001961
306 REGULATION OF INTRACELLULAR TRANSPORT 23 621 1.311e-05 0.0001988
307 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 11 162 1.31e-05 0.0001988
308 REGULATION OF PROTEOLYSIS 25 711 1.323e-05 0.0001999
309 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 8 81 1.365e-05 0.0002056
310 DNA METHYLATION OR DEMETHYLATION 7 59 1.417e-05 0.0002126
311 REGULATION OF HISTONE DEACETYLATION 5 24 1.488e-05 0.0002223
312 ENDOCRINE PANCREAS DEVELOPMENT 6 40 1.495e-05 0.0002223
313 ENDODERMAL CELL DIFFERENTIATION 6 40 1.495e-05 0.0002223
314 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 20 498 1.552e-05 0.00023
315 POSITIVE REGULATION OF CATALYTIC ACTIVITY 41 1518 1.57e-05 0.000232
316 INTRACELLULAR SIGNAL TRANSDUCTION 42 1572 1.58e-05 0.0002327
317 CELL DIVISION 19 460 1.727e-05 0.0002534
318 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 6 41 1.732e-05 0.0002534
319 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 8 85 1.95e-05 0.0002844
320 POSITIVE REGULATION OF DNA BINDING 6 42 1.998e-05 0.0002905
321 HEART DEVELOPMENT 19 466 2.065e-05 0.0002993
322 REGULATION OF IRE1 MEDIATED UNFOLDED PROTEIN RESPONSE 4 13 2.11e-05 0.0003021
323 NEGATIVE REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 4 13 2.11e-05 0.0003021
324 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 4 13 2.11e-05 0.0003021
325 REGULATION OF CELL FATE SPECIFICATION 4 13 2.11e-05 0.0003021
326 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 8 86 2.125e-05 0.0003024
327 REGULATION OF CELL DIVISION 14 272 2.131e-05 0.0003024
328 EAR MORPHOGENESIS 9 112 2.132e-05 0.0003024
329 MUSCLE CELL DIFFERENTIATION 13 237 2.163e-05 0.0003059
330 NEGATIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 5 26 2.253e-05 0.0003177
331 CELL FATE DETERMINATION 6 43 2.296e-05 0.0003227
332 POSITIVE REGULATION OF MAPK CASCADE 19 470 2.322e-05 0.0003254
333 REGULATION OF PROTEIN ACETYLATION 7 64 2.436e-05 0.0003393
334 POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 7 64 2.436e-05 0.0003393
335 POSITIVE REGULATION OF MAP KINASE ACTIVITY 12 207 2.607e-05 0.0003622
336 CELLULAR RESPONSE TO ALCOHOL 9 115 2.634e-05 0.0003648
337 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 10 144 2.672e-05 0.0003689
338 SEGMENTATION 8 89 2.732e-05 0.0003754
339 REGULATION OF CATENIN IMPORT INTO NUCLEUS 5 27 2.735e-05 0.0003754
340 RESPONSE TO IONIZING RADIATION 10 145 2.836e-05 0.0003881
341 OUTFLOW TRACT SEPTUM MORPHOGENESIS 4 14 2.923e-05 0.0003965
342 POSITIVE REGULATION OF HISTONE DEACETYLATION 4 14 2.923e-05 0.0003965
343 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 4 14 2.923e-05 0.0003965
344 DNA METHYLATION 6 45 2.998e-05 0.0004041
345 PROTEIN METHYLATION 9 117 3.022e-05 0.0004041
346 MAMMARY GLAND DEVELOPMENT 9 117 3.022e-05 0.0004041
347 PROTEIN ALKYLATION 9 117 3.022e-05 0.0004041
348 DNA ALKYLATION 6 45 2.998e-05 0.0004041
349 REPRODUCTION 36 1297 3.123e-05 0.0004164
350 CELLULAR RESPONSE TO LIGHT STIMULUS 8 91 3.212e-05 0.000427
351 CELL FATE COMMITMENT INVOLVED IN FORMATION OF PRIMARY GERM LAYER 5 28 3.293e-05 0.0004354
352 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 67 3.294e-05 0.0004354
353 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 15 321 3.349e-05 0.0004414
354 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 12 213 3.453e-05 0.0004519
355 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 119 3.457e-05 0.0004519
356 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 12 213 3.453e-05 0.0004519
357 POSITIVE REGULATION OF VIRAL PROCESS 8 92 3.477e-05 0.0004532
358 NEGATIVE REGULATION OF CELL CYCLE PROCESS 12 214 3.615e-05 0.0004698
359 NEGATIVE REGULATION OF KINASE ACTIVITY 13 250 3.775e-05 0.0004893
360 RESPONSE TO KETONE 11 182 3.866e-05 0.0004997
361 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 29 3.935e-05 0.0005042
362 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 5 29 3.935e-05 0.0005042
363 MUSCLE CELL FATE COMMITMENT 4 15 3.944e-05 0.0005042
364 REGULATION OF PROTEIN KINASE B SIGNALING 9 121 3.944e-05 0.0005042
365 REGULATION OF HOMEOSTATIC PROCESS 18 447 4.015e-05 0.0005118
366 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 9 122 4.209e-05 0.0005351
367 REGULATION OF MUSCLE CELL DIFFERENTIATION 10 152 4.248e-05 0.0005371
368 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 10 152 4.248e-05 0.0005371
369 VIRAL LIFE CYCLE 14 290 4.305e-05 0.0005429
370 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 30 1008 4.322e-05 0.0005435
371 CELLULAR CATABOLIC PROCESS 36 1322 4.645e-05 0.0005825
372 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 16 370 4.673e-05 0.0005845
373 SKIN EPIDERMIS DEVELOPMENT 7 71 4.812e-05 0.0006002
374 CARDIAC SEPTUM MORPHOGENESIS 6 49 4.921e-05 0.0006122
375 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 27 867 4.983e-05 0.0006182
376 KIDNEY EPITHELIUM DEVELOPMENT 9 125 5.095e-05 0.0006305
377 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 11 188 5.196e-05 0.0006413
378 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 13 258 5.22e-05 0.0006425
379 RESPONSE TO VITAMIN 8 98 5.483e-05 0.0006732
380 PHOSPHORYLATION 34 1228 5.556e-05 0.0006804
381 EMBRYONIC HEART TUBE DEVELOPMENT 7 73 5.762e-05 0.0007008
382 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 9 127 5.769e-05 0.0007008
383 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 7 73 5.762e-05 0.0007008
384 HOMEOSTATIC PROCESS 36 1337 5.855e-05 0.0007095
385 HOMOTYPIC CELL CELL ADHESION 6 51 6.196e-05 0.0007488
386 REGULATION OF BODY FLUID LEVELS 19 506 6.283e-05 0.0007559
387 PROTEIN AUTOPHOSPHORYLATION 11 192 6.287e-05 0.0007559
388 ENDOCARDIAL CUSHION DEVELOPMENT 5 32 6.456e-05 0.0007742
389 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 16 381 6.607e-05 0.0007903
390 REGULATION OF DNA REPAIR 7 75 6.86e-05 0.0008184
391 REGULATION OF DNA REPLICATION 10 161 6.91e-05 0.0008202
392 CELL CYCLE CHECKPOINT 11 194 6.903e-05 0.0008202
393 REGULATION OF IMMUNE SYSTEM PROCESS 37 1403 7.054e-05 0.0008351
394 EXTRACELLULAR STRUCTURE ORGANIZATION 14 304 7.152e-05 0.0008446
395 RESPONSE TO BIOTIC STIMULUS 27 886 7.178e-05 0.0008456
396 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 10 162 7.278e-05 0.0008552
397 GLIAL CELL DEVELOPMENT 7 76 7.469e-05 0.0008754
398 RESPONSE TO VITAMIN D 5 33 7.526e-05 0.0008798
399 REGULATION OF CELL PROJECTION ORGANIZATION 20 558 7.644e-05 0.0008914
400 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 19 514 7.729e-05 0.000899
401 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 11 197 7.923e-05 0.0009193
402 CELL CELL ADHESION 21 608 8.535e-05 0.0009879
403 POSITIVE REGULATION OF PROTEIN DEACETYLATION 4 18 8.563e-05 0.0009887
404 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 5 34 8.727e-05 0.001
405 REGULATION OF PROTEIN DEACETYLATION 5 34 8.727e-05 0.001
406 PROTEIN DESTABILIZATION 5 34 8.727e-05 0.001
407 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 25 799 8.882e-05 0.001015
408 ODONTOGENESIS 8 105 8.958e-05 0.001022
409 MRNA METABOLIC PROCESS 21 611 9.145e-05 0.00104
410 NEGATIVE REGULATION OF GROWTH 12 236 9.278e-05 0.001053
411 SPINAL CORD DEVELOPMENT 8 106 9.578e-05 0.001079
412 NEGATIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 6 55 9.533e-05 0.001079
413 DNA MODIFICATION 7 79 9.57e-05 0.001079
414 CELL PROJECTION ORGANIZATION 27 902 9.666e-05 0.001086
415 MUSCLE TISSUE DEVELOPMENT 13 275 9.961e-05 0.001117
416 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 17 437 0.0001001 0.00112
417 POSITIVE REGULATION OF CATABOLIC PROCESS 16 395 0.0001006 0.00112
418 POSITIVE REGULATION OF GROWTH 12 238 0.0001005 0.00112
419 RESPONSE TO RETINOIC ACID 8 107 0.0001023 0.001136
420 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 4 19 0.0001073 0.001186
421 ASTROCYTE DEVELOPMENT 4 19 0.0001073 0.001186
422 REGULATION OF SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 11 205 0.0001129 0.001245
423 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 5 36 0.0001157 0.001272
424 RESPONSE TO ACID CHEMICAL 14 319 0.0001191 0.0013
425 REGULATION OF MAP KINASE ACTIVITY 14 319 0.0001191 0.0013
426 CATABOLIC PROCESS 43 1773 0.0001185 0.0013
427 NEURON PROJECTION MORPHOGENESIS 16 402 0.0001232 0.001343
428 POSITIVE REGULATION OF LIGASE ACTIVITY 8 110 0.0001242 0.001351
429 INTERMEDIATE FILAMENT ORGANIZATION 4 20 0.0001327 0.001423
430 HINDLIMB MORPHOGENESIS 5 37 0.0001323 0.001423
431 POSITIVE REGULATION OF B CELL PROLIFERATION 5 37 0.0001323 0.001423
432 ENDOPLASMIC RETICULUM CALCIUM ION HOMEOSTASIS 4 20 0.0001327 0.001423
433 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 8 111 0.0001323 0.001423
434 REGULATION OF TRANSCRIPTION INVOLVED IN CELL FATE COMMITMENT 4 20 0.0001327 0.001423
435 NEGATIVE REGULATION OF GENE EXPRESSION EPIGENETIC 8 112 0.0001409 0.001507
436 ANATOMICAL STRUCTURE HOMEOSTASIS 13 285 0.0001421 0.001517
437 RESPONSE TO VIRUS 12 247 0.0001425 0.001517
438 SKIN DEVELOPMENT 11 211 0.0001456 0.001547
439 REGULATION OF NEURON PROJECTION DEVELOPMENT 16 408 0.000146 0.001548
440 POSITIVE REGULATION OF DNA REPAIR 5 38 0.0001506 0.001589
441 POSITIVE REGULATION OF ORGAN GROWTH 5 38 0.0001506 0.001589
442 REGULATION OF CATABOLIC PROCESS 23 731 0.0001577 0.001659
443 BIOLOGICAL ADHESION 29 1032 0.0001579 0.001659
444 LEFT RIGHT PATTERN FORMATION 4 21 0.0001622 0.0017
445 POSITIVE REGULATION OF B CELL ACTIVATION 7 86 0.0001637 0.001712
446 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 115 0.0001693 0.001762
447 PROTEIN SUMOYLATION 8 115 0.0001693 0.001762
448 EMBRYONIC DIGIT MORPHOGENESIS 6 61 0.0001707 0.001771
449 GLANDULAR EPITHELIAL CELL DIFFERENTIATION 5 39 0.0001709 0.001771
450 TISSUE REMODELING 7 87 0.000176 0.00182
451 POSITIVE REGULATION OF TRANSPORT 27 936 0.0001767 0.001823
452 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 9 147 0.0001773 0.001825
453 SOMITOGENESIS 6 62 0.0001868 0.001911
454 ANGIOGENESIS 13 293 0.0001866 0.001911
455 EMBRYONIC HEART TUBE MORPHOGENESIS 6 62 0.0001868 0.001911
456 SPECIFICATION OF SYMMETRY 8 117 0.0001907 0.001941
457 CELLULAR RESPONSE TO STARVATION 8 117 0.0001907 0.001941
458 LEUKOCYTE CELL CELL ADHESION 12 255 0.0001916 0.001946
459 RESPONSE TO HORMONE 26 893 0.0002023 0.002046
460 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 8 118 0.0002022 0.002046
461 TAXIS 17 464 0.0002044 0.002063
462 AXIS SPECIFICATION 7 90 0.0002175 0.002182
463 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 5 41 0.0002176 0.002182
464 PROSTATE GLAND DEVELOPMENT 5 41 0.0002176 0.002182
465 EPITHELIAL CELL DEVELOPMENT 10 186 0.0002268 0.002269
466 DORSAL VENTRAL PATTERN FORMATION 7 91 0.0002329 0.002326
467 REGULATION OF B CELL ACTIVATION 8 121 0.0002402 0.002393
468 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 5 42 0.0002443 0.002424
469 REGULATION OF HEART GROWTH 5 42 0.0002443 0.002424
470 INNER EAR MORPHOGENESIS 7 92 0.0002493 0.002468
471 AMEBOIDAL TYPE CELL MIGRATION 9 154 0.0002512 0.002482
472 MYELOID CELL DIFFERENTIATION 10 189 0.000258 0.002543
473 T CELL DIFFERENTIATION 8 123 0.0002687 0.002642
474 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 10 190 0.0002691 0.002642
475 INTERMEDIATE FILAMENT BASED PROCESS 5 43 0.0002734 0.002678
476 RNA CATABOLIC PROCESS 11 227 0.0002746 0.002684
477 BONE DEVELOPMENT 9 156 0.0002765 0.002692
478 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 9 156 0.0002765 0.002692
479 RESPONSE TO NUTRIENT 10 191 0.0002807 0.002726
480 RESPONSE TO BMP 7 94 0.0002847 0.002752
481 CELLULAR RESPONSE TO BMP STIMULUS 7 94 0.0002847 0.002752
482 TELENCEPHALON DEVELOPMENT 11 228 0.0002851 0.002752
483 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 6 67 0.0002867 0.002757
484 NEURON FATE COMMITMENT 6 67 0.0002867 0.002757
485 POSITIVE REGULATION OF MULTI ORGANISM PROCESS 9 157 0.00029 0.002782
486 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 10 192 0.0002926 0.002802
487 NEGATIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS 5 44 0.0003051 0.002915
488 REGULATION OF CELLULAR COMPONENT BIOGENESIS 23 767 0.0003139 0.002993
489 CELLULAR RESPONSE TO EPIDERMAL GROWTH FACTOR STIMULUS 4 25 0.0003286 0.003121
490 THYROID GLAND DEVELOPMENT 4 25 0.0003286 0.003121
491 POSITIVE REGULATION OF BINDING 8 127 0.0003339 0.00316
492 PROTEASOMAL PROTEIN CATABOLIC PROCESS 12 271 0.0003342 0.00316
493 EXOCRINE SYSTEM DEVELOPMENT 5 45 0.0003395 0.003204
494 REGULATION OF TRANSPORT 42 1804 0.0003433 0.003234
495 PROTEIN ACETYLATION 8 129 0.000371 0.003467
496 POSITIVE REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 3 11 0.0003705 0.003467
497 NEGATIVE REGULATION OF CELLULAR SENESCENCE 3 11 0.0003705 0.003467
498 REGULATION OF HISTONE H4 ACETYLATION 3 11 0.0003705 0.003467
499 PROTEIN COMPLEX SUBUNIT ORGANIZATION 37 1527 0.0003795 0.003539
500 CELLULAR RESPONSE TO BIOTIC STIMULUS 9 163 0.0003823 0.003548
501 TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 4 26 0.0003843 0.003548
502 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 4 26 0.0003843 0.003548
503 REGULATION OF P38MAPK CASCADE 4 26 0.0003843 0.003548
504 REGULATION OF CELL FATE COMMITMENT 4 26 0.0003843 0.003548
505 REGULATION OF LIGASE ACTIVITY 8 130 0.0003908 0.003601
506 MUSCLE ORGAN DEVELOPMENT 12 277 0.000407 0.003743
507 PROTEIN STABILIZATION 8 131 0.0004115 0.003776
508 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 7 100 0.0004157 0.003808
509 POSITIVE REGULATION OF GLIOGENESIS 5 47 0.000417 0.003812
510 MITOTIC NUCLEAR DIVISION 14 361 0.0004216 0.003839
511 REGULATION OF ION HOMEOSTASIS 10 201 0.0004208 0.003839
512 NEGATIVE REGULATION OF FIBROBLAST PROLIFERATION 4 27 0.0004463 0.004025
513 PROTEIN K11 LINKED UBIQUITINATION 4 27 0.0004463 0.004025
514 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 4 27 0.0004463 0.004025
515 REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE 4 27 0.0004463 0.004025
516 REGULATION OF APOPTOTIC SIGNALING PATHWAY 14 363 0.0004454 0.004025
517 RESPONSE TO LIGHT STIMULUS 12 280 0.0004482 0.004034
518 PROTEOLYSIS 31 1208 0.0004535 0.004074
519 PANCREAS DEVELOPMENT 6 73 0.0004573 0.004092
520 G1 DNA DAMAGE CHECKPOINT 6 73 0.0004573 0.004092
521 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 13 323 0.0004757 0.004249
522 INTERACTION WITH HOST 8 134 0.0004788 0.004268
523 POSITIVE REGULATION OF CATENIN IMPORT INTO NUCLEUS 3 12 0.0004891 0.004352
524 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 74 0.000492 0.004353
525 NEURON PROJECTION GUIDANCE 10 205 0.0004912 0.004353
526 PEPTIDYL LYSINE METHYLATION 6 74 0.000492 0.004353
527 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 14 368 0.00051 0.004503
528 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 28 0.0005152 0.004523
529 REGULATION OF NEUROBLAST PROLIFERATION 4 28 0.0005152 0.004523
530 REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 4 28 0.0005152 0.004523
531 NEGATIVE REGULATION OF CELL GROWTH 9 170 0.0005193 0.004551
532 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 6 75 0.0005289 0.004617
533 REGULATION OF VIRAL GENOME REPLICATION 6 75 0.0005289 0.004617
534 FACE DEVELOPMENT 5 50 0.0005574 0.004847
535 HISTONE H4 ACETYLATION 5 50 0.0005574 0.004847
536 RESPONSE TO MECHANICAL STIMULUS 10 210 0.0005927 0.005145
537 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 5 51 0.0006112 0.005286
538 MITOTIC CELL CYCLE CHECKPOINT 8 139 0.0006106 0.005286
539 REGULATION OF PROTEIN COMPLEX ASSEMBLY 14 375 0.0006137 0.005298
540 REGULATION OF IMMUNE RESPONSE 24 858 0.0006301 0.00538
541 MITOTIC CELL CYCLE ARREST 3 13 0.0006295 0.00538
542 EYELID DEVELOPMENT IN CAMERA TYPE EYE 3 13 0.0006295 0.00538
543 PERIPHERAL NERVOUS SYSTEM NEURON DIFFERENTIATION 3 13 0.0006295 0.00538
544 PERIPHERAL NERVOUS SYSTEM NEURON DEVELOPMENT 3 13 0.0006295 0.00538
545 ENDODERMAL CELL FATE COMMITMENT 3 13 0.0006295 0.00538
546 CARDIAC MUSCLE TISSUE DEVELOPMENT 8 140 0.0006402 0.005456
547 RESPONSE TO CORTICOSTEROID 9 176 0.0006667 0.005671
548 CELLULAR RESPONSE TO IONIZING RADIATION 5 52 0.0006689 0.005679
549 POSITIVE REGULATION OF VIRAL GENOME REPLICATION 4 30 0.0006752 0.005712
550 RESPONSE TO EPIDERMAL GROWTH FACTOR 4 30 0.0006752 0.005712
551 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 6 79 0.0006981 0.005884
552 BONE MORPHOGENESIS 6 79 0.0006981 0.005884
553 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 5 53 0.0007305 0.006113
554 MAMMARY GLAND EPITHELIUM DEVELOPMENT 5 53 0.0007305 0.006113
555 RRNA METABOLIC PROCESS 11 255 0.0007292 0.006113
556 INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR 5 53 0.0007305 0.006113
557 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 15 427 0.0007399 0.006181
558 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 6 80 0.0007462 0.006223
559 RHYTHMIC PROCESS 12 298 0.0007762 0.006461
560 HISTONE H3 K9 MODIFICATION 3 14 0.0007932 0.006556
561 POSITIVE REGULATION OF P38MAPK CASCADE 3 14 0.0007932 0.006556
562 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 10 218 0.0007908 0.006556
563 CONVERGENT EXTENSION 3 14 0.0007932 0.006556
564 CELL DIFFERENTIATION IN SPINAL CORD 5 54 0.0007963 0.006557
565 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 5 54 0.0007963 0.006557
566 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 8 145 0.000806 0.006626
567 NCRNA PROCESSING 14 386 0.0008127 0.006669
568 LEUKOCYTE MIGRATION 11 259 0.0008284 0.006786
569 DNA INTEGRITY CHECKPOINT 8 146 0.0008429 0.006893
570 INTEGRIN MEDIATED SIGNALING PATHWAY 6 82 0.0008503 0.006941
571 SALIVARY GLAND DEVELOPMENT 4 32 0.0008674 0.007007
572 REGULATION OF KIDNEY DEVELOPMENT 5 55 0.0008663 0.007007
573 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 4 32 0.0008674 0.007007
574 CRANIAL SKELETAL SYSTEM DEVELOPMENT 5 55 0.0008663 0.007007
575 REGULATION OF B CELL PROLIFERATION 5 55 0.0008663 0.007007
576 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 0.0008674 0.007007
577 ORGAN REGENERATION 6 83 0.0009064 0.007309
578 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 11 263 0.0009386 0.007543
579 PROTEIN CATABOLIC PROCESS 18 579 0.0009377 0.007543
580 REGULATION OF PEPTIDASE ACTIVITY 14 392 0.0009425 0.007561
581 REGULATION OF CELL ACTIVATION 16 484 0.0009476 0.007589
582 NEPHRON DEVELOPMENT 7 115 0.0009592 0.007668
583 REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY 3 15 0.0009817 0.007742
584 CELLULAR SENESCENCE 4 33 0.0009767 0.007742
585 NEGATIVE REGULATION OF HISTONE ACETYLATION 3 15 0.0009817 0.007742
586 REGULATION OF MESODERM DEVELOPMENT 3 15 0.0009817 0.007742
587 IMMUNE RESPONSE 28 1100 0.0009755 0.007742
588 POSITIVE REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY 3 15 0.0009817 0.007742
589 NEURON PROJECTION REGENERATION 4 33 0.0009767 0.007742
590 POSITIVE REGULATION OF NUCLEASE ACTIVITY 3 15 0.0009817 0.007742
591 PEPTIDYL TYROSINE MODIFICATION 9 186 0.0009872 0.007772
592 CHROMATIN REMODELING 8 150 0.001005 0.007896
593 APOPTOTIC MITOCHONDRIAL CHANGES 5 57 0.00102 0.008005
594 CARDIAC SEPTUM DEVELOPMENT 6 85 0.001027 0.008031
595 EPHRIN RECEPTOR SIGNALING PATHWAY 6 85 0.001027 0.008031
596 CELL PART MORPHOGENESIS 19 633 0.001029 0.008037
597 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 117 0.001061 0.008272
598 POSITIVE REGULATION OF DNA REPLICATION 6 86 0.001092 0.00848
599 ORGAN FORMATION 4 34 0.001095 0.00848
600 REGULATION OF MESENCHYMAL CELL PROLIFERATION 4 34 0.001095 0.00848
601 NEURAL TUBE PATTERNING 4 34 0.001095 0.00848
602 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 10 228 0.001112 0.008594
603 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 7 118 0.001115 0.008608
604 POSITIVE REGULATION OF CELL ACTIVATION 12 311 0.001122 0.008642
605 PALLIUM DEVELOPMENT 8 153 0.001141 0.008779
606 MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION 3 16 0.001196 0.009095
607 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 8 154 0.00119 0.009095
608 ORGAN INDUCTION 3 16 0.001196 0.009095
609 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 3 16 0.001196 0.009095
610 ATRIOVENTRICULAR VALVE MORPHOGENESIS 3 16 0.001196 0.009095
611 RESPONSE TO UV B 3 16 0.001196 0.009095
612 RESPONSE TO STARVATION 8 154 0.00119 0.009095
613 BONE REMODELING 4 35 0.001224 0.009273
614 RESPONSE TO MINERALOCORTICOID 4 35 0.001224 0.009273
615 RNA MODIFICATION 7 120 0.00123 0.009309
616 NEGATIVE REGULATION OF CELL DIVISION 5 60 0.001288 0.009727
617 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 274 0.001306 0.009845
618 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 14 406 0.001315 0.009899
619 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 13 361 0.001321 0.009926
NumGOOverlapSizeP ValueAdj. P Value
1 SEQUENCE SPECIFIC DNA BINDING 56 1037 2.637e-19 2.45e-16
2 REGULATORY REGION NUCLEIC ACID BINDING 45 818 7.454e-16 3.463e-13
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 52 1199 5.193e-14 1.608e-11
4 CHROMATIN BINDING 30 435 2.553e-13 5.929e-11
5 MACROMOLECULAR COMPLEX BINDING 55 1399 4.711e-13 8.753e-11
6 DOUBLE STRANDED DNA BINDING 39 764 8.361e-13 1.294e-10
7 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 34 629 5.924e-12 7.862e-10
8 RNA BINDING 57 1598 8.562e-12 9.942e-10
9 IDENTICAL PROTEIN BINDING 47 1209 4.696e-11 4.363e-09
10 CORE PROMOTER PROXIMAL REGION DNA BINDING 25 371 4.571e-11 4.363e-09
11 TRANSCRIPTION FACTOR BINDING 29 524 1.377e-10 1.163e-08
12 POLY A RNA BINDING 45 1170 1.836e-10 1.422e-08
13 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 7.644e-10 5.462e-08
14 PROTEIN DIMERIZATION ACTIVITY 42 1149 3.676e-09 2.439e-07
15 STRUCTURAL CONSTITUENT OF CYTOSKELETON 12 100 1.051e-08 6.509e-07
16 ENZYME BINDING 53 1737 1.358e-08 7.887e-07
17 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 26 588 1.255e-07 6.858e-06
18 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 18 315 3.116e-07 1.608e-05
19 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 13 168 4.889e-07 2.39e-05
20 HISTONE METHYLTRANSFERASE ACTIVITY 8 58 1.063e-06 4.939e-05
21 PROTEIN HETERODIMERIZATION ACTIVITY 21 468 1.703e-06 7.19e-05
22 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE REGULATOR ACTIVITY 6 28 1.681e-06 7.19e-05
23 ZINC ION BINDING 36 1155 2.474e-06 9.989e-05
24 RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC DNA BINDING 8 65 2.58e-06 9.989e-05
25 TRANSCRIPTION COACTIVATOR ACTIVITY 16 296 2.942e-06 0.0001093
26 CYCLIN BINDING 5 19 4.303e-06 0.0001538
27 PROTEIN DOMAIN SPECIFIC BINDING 24 624 4.487e-06 0.0001544
28 ENHANCER BINDING 9 93 4.663e-06 0.0001547
29 STRUCTURAL MOLECULE ACTIVITY 26 732 7.385e-06 0.0002366
30 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 105 1.265e-05 0.0003919
31 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 13 226 1.308e-05 0.0003919
32 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 4 12 1.477e-05 0.0004209
33 PROTEIN METHYLTRANSFERASE ACTIVITY 8 82 1.495e-05 0.0004209
34 PROTEIN HOMODIMERIZATION ACTIVITY 25 722 1.713e-05 0.0004679
35 INTERMEDIATE FILAMENT BINDING 4 13 2.11e-05 0.0005601
36 N METHYLTRANSFERASE ACTIVITY 8 88 2.515e-05 0.000649
37 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 8 90 2.964e-05 0.0007336
38 TRANSITION METAL ION BINDING 38 1400 3.001e-05 0.0007336
39 KINASE REGULATOR ACTIVITY 11 186 4.715e-05 0.001123
40 UBIQUITIN LIKE PROTEIN LIGASE BINDING 13 264 6.599e-05 0.001533
41 METHYLATED HISTONE BINDING 6 52 6.925e-05 0.001568
42 PROTEIN COMPLEX BINDING 28 935 7.089e-05 0.001568
43 NAD BINDING 6 53 7.722e-05 0.001668
44 S ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE ACTIVITY 9 139 0.0001159 0.002409
45 REPRESSING TRANSCRIPTION FACTOR BINDING 6 57 0.0001167 0.002409
46 DOUBLE STRANDED RNA BINDING 6 64 0.0002228 0.0045
47 SCAFFOLD PROTEIN BINDING 5 45 0.0003395 0.006571
48 HISTONE LYSINE N METHYLTRANSFERASE ACTIVITY 5 45 0.0003395 0.006571
49 GLYCOPROTEIN BINDING 7 101 0.0004416 0.008373
50 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 7 104 0.0005271 0.009793
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMATIN 31 441 5.948e-14 3.473e-11
2 CHROMOSOME 40 880 1.547e-11 4.518e-09
3 NUCLEAR CHROMOSOME 29 523 1.316e-10 2.5e-08
4 NUCLEAR UBIQUITIN LIGASE COMPLEX 10 42 1.713e-10 2.5e-08
5 NUCLEAR CHROMATIN 21 291 5.013e-10 5.855e-08
6 TRANSCRIPTION FACTOR COMPLEX 20 298 4.589e-09 4.467e-07
7 RIBONUCLEOPROTEIN COMPLEX 30 721 4.892e-08 4.081e-06
8 PCG PROTEIN COMPLEX 8 43 9.581e-08 6.994e-06
9 HETEROCHROMATIN 9 67 2.813e-07 1.826e-05
10 PRC1 COMPLEX 5 12 3.167e-07 1.85e-05
11 TRANSFERASE COMPLEX 27 703 1.133e-06 6.014e-05
12 CATALYTIC COMPLEX 33 1038 4.468e-06 0.0002174
13 NUCLEOPLASM PART 25 708 1.232e-05 0.0005535
14 CELL SURFACE 26 757 1.328e-05 0.0005541
15 SUPRAMOLECULAR FIBER 24 670 1.466e-05 0.0005707
16 CELL SUBSTRATE JUNCTION 17 398 3.164e-05 0.001155
17 NUCLEOLUS 27 848 3.412e-05 0.001172
18 ANCHORING JUNCTION 19 489 3.979e-05 0.001291
19 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 9 127 5.769e-05 0.001684
20 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 5 31 5.508e-05 0.001684
21 ANAPHASE PROMOTING COMPLEX 4 22 0.0001962 0.005456
22 CYTOSKELETAL PART 36 1436 0.000241 0.006398

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04110_Cell_cycle 20 128 6.496e-16 1.169e-13
2 hsa04510_Focal_adhesion 16 200 1.437e-08 1.294e-06
3 hsa04310_Wnt_signaling_pathway 13 151 1.417e-07 8.028e-06
4 hsa04390_Hippo_signaling_pathway 13 154 1.784e-07 8.028e-06
5 hsa04151_PI3K_AKT_signaling_pathway 19 351 3.343e-07 1.203e-05
6 hsa04540_Gap_junction 9 90 3.546e-06 0.0001049
7 hsa04115_p53_signaling_pathway 8 69 4.08e-06 0.0001049
8 hsa04810_Regulation_of_actin_cytoskeleton 13 214 7.279e-06 0.0001638
9 hsa03015_mRNA_surveillance_pathway 8 83 1.636e-05 0.0003271
10 hsa04012_ErbB_signaling_pathway 8 87 2.313e-05 0.0004164
11 hsa04330_Notch_signaling_pathway 6 47 3.864e-05 0.0006324
12 hsa04520_Adherens_junction 7 73 5.762e-05 0.0008642
13 hsa04320_Dorso.ventral_axis_formation 4 25 0.0003286 0.00455
14 hsa04660_T_cell_receptor_signaling_pathway 7 108 0.000661 0.008499
15 hsa04350_TGF.beta_signaling_pathway 6 85 0.001027 0.01194
16 hsa04670_Leukocyte_transendothelial_migration 7 117 0.001061 0.01194
17 hsa04912_GnRH_signaling_pathway 6 101 0.002489 0.02636
18 hsa04010_MAPK_signaling_pathway 10 268 0.003619 0.03619
19 hsa04672_Intestinal_immune_network_for_IgA_production 4 49 0.004273 0.04048
20 hsa04114_Oocyte_meiosis 6 114 0.004533 0.0408
21 hsa04145_Phagosome 7 156 0.005355 0.0459
22 hsa04512_ECM.receptor_interaction 5 85 0.005893 0.04821
23 hsa04340_Hedgehog_signaling_pathway 4 56 0.006883 0.05387
24 hsa04722_Neurotrophin_signaling_pathway 6 127 0.007607 0.0546
25 hsa03040_Spliceosome 6 128 0.007894 0.0546
26 hsa04380_Osteoclast_differentiation 6 128 0.007894 0.0546
27 hsa03010_Ribosome 5 92 0.00819 0.0546
28 hsa04530_Tight_junction 6 133 0.009443 0.0607
29 hsa04650_Natural_killer_cell_mediated_cytotoxicity 6 136 0.01047 0.06499
30 hsa04916_Melanogenesis 5 101 0.01197 0.07183
31 hsa04620_Toll.like_receptor_signaling_pathway 5 102 0.01245 0.07231
32 hsa04920_Adipocytokine_signaling_pathway 4 68 0.01347 0.07575
33 hsa04014_Ras_signaling_pathway 8 236 0.01515 0.08262
34 hsa04662_B_cell_receptor_signaling_pathway 4 75 0.01869 0.09895
35 hsa04370_VEGF_signaling_pathway 4 76 0.01953 0.1004
36 hsa00310_Lysine_degradation 3 44 0.02145 0.1072
37 hsa04664_Fc_epsilon_RI_signaling_pathway 4 79 0.02217 0.1078
38 hsa04974_Protein_digestion_and_absorption 4 81 0.02404 0.1139
39 hsa04914_Progesterone.mediated_oocyte_maturation 4 87 0.03024 0.1396
40 hsa04640_Hematopoietic_cell_lineage 4 88 0.03135 0.1411
41 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.04048 0.1777
42 hsa03013_RNA_transport 5 152 0.05551 0.2379
43 hsa04144_Endocytosis 6 203 0.05781 0.242
44 hsa04630_Jak.STAT_signaling_pathway 5 155 0.05938 0.2429
45 hsa04141_Protein_processing_in_endoplasmic_reticulum 5 168 0.07787 0.3115
46 hsa03030_DNA_replication 2 36 0.08479 0.3318
47 hsa03008_Ribosome_biogenesis_in_eukaryotes 3 81 0.09666 0.3702
48 hsa04514_Cell_adhesion_molecules_.CAMs. 4 136 0.1126 0.4222
49 hsa04210_Apoptosis 3 89 0.1193 0.4381
50 hsa03050_Proteasome 2 45 0.1233 0.444
51 hsa04621_NOD.like_receptor_signaling_pathway 2 59 0.1893 0.6554
52 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.2068 0.6893
53 hsa04610_Complement_and_coagulation_cascades 2 69 0.2388 0.7567
54 hsa03320_PPAR_signaling_pathway 2 70 0.2438 0.7567
55 hsa04720_Long.term_potentiation 2 70 0.2438 0.7567
56 hsa04730_Long.term_depression 2 70 0.2438 0.7567
57 hsa03018_RNA_degradation 2 71 0.2488 0.7591
58 hsa04360_Axon_guidance 3 130 0.2567 0.7674
59 hsa04970_Salivary_secretion 2 89 0.3386 0.9375
60 hsa04910_Insulin_signaling_pathway 2 138 0.5582 1
61 hsa04020_Calcium_signaling_pathway 2 177 0.6927 1
62 hsa04062_Chemokine_signaling_pathway 2 189 0.7267 1

Quest ID: efac3afcc860b7ed5dcd8120923500c4