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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-194-5p ANGPTL1 0.69 0.52314 -8.04 0 MirTarget -0.15 0.02902 NA
2 hsa-miR-194-5p ASAP1 0.69 0.52314 -0.15 0.71428 MirTarget; miRNATAP -0.13 0 NA
3 hsa-miR-194-5p ATP8B4 0.69 0.52314 -2.31 0.00034 MirTarget -0.12 0.00043 NA
4 hsa-miR-194-5p BICD2 0.69 0.52314 0.86 0.21413 miRNATAP -0.38 0 NA
5 hsa-miR-194-5p BNC1 0.69 0.52314 5.47 0.02957 MirTarget -1.31 0 NA
6 hsa-miR-194-5p BNIP2 0.69 0.52314 -0.41 0.18881 MirTarget -0.12 0 NA
7 hsa-miR-194-5p BRMS1L 0.69 0.52314 -0.03 0.94633 MirTarget -0.14 0 NA
8 hsa-miR-194-5p C18orf25 0.69 0.52314 0.65 0.03338 miRNATAP -0.11 0 NA
9 hsa-miR-194-5p CEP170 0.69 0.52314 -0.15 0.75249 miRNATAP -0.11 1.0E-5 NA
10 hsa-miR-194-5p CLIP4 0.69 0.52314 -0.83 0.29386 MirTarget -0.35 0 NA
11 hsa-miR-194-5p CYP26B1 0.69 0.52314 1.59 0.0886 mirMAP -0.25 0 NA
12 hsa-miR-194-5p DAAM1 0.69 0.52314 0.28 0.67526 miRNATAP -0.17 0 NA
13 hsa-miR-194-5p DUSP9 0.69 0.52314 6.66 4.0E-5 MirTarget; miRNATAP -0.53 0 NA
14 hsa-miR-194-5p EGR2 0.69 0.52314 -1.39 0.09323 miRNATAP -0.12 0.00526 NA
15 hsa-miR-194-5p ENAH 0.69 0.52314 -0.27 0.60264 mirMAP; miRNATAP -0.18 0 NA
16 hsa-miR-194-5p ERG 0.69 0.52314 -2.93 5.0E-5 MirTarget -0.21 0 NA
17 hsa-miR-194-5p FGFR3 0.69 0.52314 3.49 0.00307 miRNATAP -0.21 0.00062 NA
18 hsa-miR-194-5p FKBP6 0.69 0.52314 4.72 0.00139 miRNATAP -0.4 0 NA
19 hsa-miR-194-5p FLI1 0.69 0.52314 -2.51 0.00017 MirTarget -0.12 0.00084 NA
20 hsa-miR-194-5p FZD6 0.69 0.52314 1.58 0.00919 MirTarget -0.25 0 NA
21 hsa-miR-194-5p GRHL3 0.69 0.52314 7.35 0 MirTarget -0.45 0 NA
22 hsa-miR-194-5p HBEGF 0.69 0.52314 -0.07 0.93961 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.24 0 NA
23 hsa-miR-194-5p IGF1R 0.69 0.52314 -0.35 0.58959 miRNAWalker2 validate; miRTarBase; miRNATAP -0.19 0 NA
24 hsa-miR-126-5p ITGB6 -0.42 0.32997 6.67 0 MirTarget -0.42 0.00425 NA
25 hsa-miR-197-3p ITGB6 1.24 0.00733 6.67 0 MirTarget -0.43 0.00153 NA
26 hsa-miR-335-5p ITGB6 0.17 0.8039 6.67 0 miRNAWalker2 validate -0.24 0.00921 NA
27 hsa-miR-194-5p KLF12 0.69 0.52314 -0.51 0.48767 MirTarget -0.11 0.00433 NA
28 hsa-miR-194-5p KLF7 0.69 0.52314 0.14 0.86538 miRNATAP -0.15 0.00044 NA
29 hsa-miR-194-5p LHX6 0.69 0.52314 -2.26 0.00168 miRNATAP -0.16 1.0E-5 NA
30 hsa-miR-194-5p LIMK2 0.69 0.52314 1.43 0.00024 miRNATAP -0.14 0 NA
31 hsa-miR-194-5p MAF 0.69 0.52314 -1.68 0.06488 miRNATAP -0.36 0 NA
32 hsa-miR-194-5p MAP1B 0.69 0.52314 -3.21 0.00229 MirTarget -0.18 0.00142 NA
33 hsa-miR-194-5p MPZL2 0.69 0.52314 1.8 0.00596 MirTarget -0.16 0 NA
34 hsa-miR-194-5p MTSS1 0.69 0.52314 1.67 0.14592 MirTarget; miRNATAP -0.56 0 NA
35 hsa-miR-194-5p MYH10 0.69 0.52314 -2.11 0.01498 miRNATAP -0.14 0.00227 NA
36 hsa-miR-194-5p MYO5A 0.69 0.52314 -0.13 0.84407 mirMAP -0.34 0 NA
37 hsa-miR-194-5p NAA50 0.69 0.52314 1.23 0.00042 MirTarget; miRNATAP -0.1 0 NA
38 hsa-miR-194-5p NLN 0.69 0.52314 1.05 0.04092 mirMAP -0.1 0.00014 NA
39 hsa-miR-194-5p NMB 0.69 0.52314 1.02 0.17555 MirTarget -0.18 0 NA
40 hsa-miR-194-5p PGAP1 0.69 0.52314 -0.49 0.41476 mirMAP -0.21 0 NA
41 hsa-miR-194-5p PHLDA1 0.69 0.52314 0.25 0.76787 MirTarget -0.18 6.0E-5 NA
42 hsa-miR-194-5p PIK3C3 0.69 0.52314 -0.06 0.84404 mirMAP -0.1 0 NA
43 hsa-miR-194-5p PITPNM2 0.69 0.52314 -0.66 0.27371 MirTarget; miRNATAP -0.21 0 NA
44 hsa-miR-194-5p PPFIBP1 0.69 0.52314 -0.47 0.32582 MirTarget -0.1 3.0E-5 NA
45 hsa-miR-194-5p PPP2R2C 0.69 0.52314 -2.54 0.14964 miRNATAP -0.29 0.00156 NA
46 hsa-miR-194-5p PTPN13 0.69 0.52314 0.29 0.73972 miRNAWalker2 validate; miRTarBase -0.31 0 NA
47 hsa-miR-194-5p RNF152 0.69 0.52314 0.01 0.99511 mirMAP -0.12 0.00849 NA
48 hsa-miR-194-5p RRAS2 0.69 0.52314 -0.65 0.37895 MirTarget -0.11 0.00442 NA
49 hsa-miR-194-5p SH3PXD2A 0.69 0.52314 -0.79 0.07818 mirMAP -0.11 0 NA
50 hsa-miR-194-5p SLC12A6 0.69 0.52314 0.79 0.20377 MirTarget -0.16 0 NA
51 hsa-miR-194-5p SLC1A3 0.69 0.52314 2.99 0.00649 MirTarget -0.32 0 NA
52 hsa-miR-194-5p SLC7A5 0.69 0.52314 4.09 3.0E-5 MirTarget -0.22 3.0E-5 NA
53 hsa-miR-194-5p SRGN 0.69 0.52314 -1.43 0.05468 MirTarget -0.1 0.00946 NA
54 hsa-miR-194-5p SRXN1 0.69 0.52314 0.64 0.2355 mirMAP -0.13 1.0E-5 NA
55 hsa-miR-194-5p TMEM43 0.69 0.52314 -1.34 0.00018 MirTarget; miRNATAP -0.12 0 NA
56 hsa-miR-194-5p TRERF1 0.69 0.52314 0.08 0.90048 mirMAP -0.19 0 NA
57 hsa-miR-194-5p TRPS1 0.69 0.52314 -0.28 0.74573 MirTarget; miRNATAP -0.16 0.00039 NA
58 hsa-miR-194-5p ZFHX4 0.69 0.52314 -3.24 0.01668 MirTarget; miRNATAP -0.15 0.03073 NA
59 hsa-miR-194-5p ZFYVE9 0.69 0.52314 -1.01 0.04627 MirTarget -0.19 0 NA
60 hsa-miR-194-5p ZNF532 0.69 0.52314 -0.65 0.18352 miRNATAP -0.21 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Regulation_of_actin_cytoskeleton_hsa04810 6 208 3.037e-05 0.001579
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.0007087 0.01673
3 mTOR_signaling_pathway_hsa04150 4 151 0.0009652 0.01673
4 Endocytosis_hsa04144 4 244 0.005476 0.06358
5 Autophagy_animal_hsa04140 3 128 0.006114 0.06358
6 MAPK_signaling_pathway_hsa04010 4 295 0.01054 0.09136
7 PI3K_Akt_signaling_pathway_hsa04151 4 352 0.019 0.1411
8 Ras_signaling_pathway_hsa04014 3 232 0.0298 0.1937
9 AMPK_signaling_pathway_hsa04152 2 121 0.04817 0.2783
10 Apelin_signaling_pathway_hsa04371 2 137 0.06004 0.3122
11 Wnt_signaling_pathway_hsa04310 2 146 0.06711 0.3172
12 Hippo_signaling_pathway_hsa04390 2 154 0.07362 0.319
13 Tight_junction_hsa04530 2 170 0.08721 0.3299
14 Focal_adhesion_hsa04510 2 199 0.1135 0.3905
15 Rap1_signaling_pathway_hsa04015 2 206 0.1202 0.3905

Quest ID: f141eadce423968924c7207b40cec3d9