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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-340-5p ABCA1 1.09 0 -1.41 0 MirTarget -0.2 0 NA
2 hsa-miR-340-5p ABCD2 1.09 0 -4.13 0 mirMAP -0.34 2.0E-5 NA
3 hsa-miR-340-5p ABHD13 1.09 0 -0.44 0 mirMAP -0.13 0 NA
4 hsa-miR-340-5p ABI2 1.09 0 -0.28 0 mirMAP -0.14 0 NA
5 hsa-miR-340-5p ACAD11 1.09 0 -1.05 0 MirTarget -0.11 0 NA
6 hsa-miR-340-5p ACAP2 1.09 0 -0.39 0 mirMAP -0.13 0 NA
7 hsa-miR-340-5p ACER3 1.09 0 -0.64 0 MirTarget -0.13 0.00024 NA
8 hsa-miR-340-5p ADAM22 1.09 0 -1.22 0 mirMAP -0.37 0 NA
9 hsa-miR-340-5p AFF4 1.09 0 -0.28 0.00153 MirTarget; miRNATAP -0.23 0 NA
10 hsa-miR-340-5p AHCYL1 1.09 0 -0.15 0.02457 mirMAP -0.15 0 NA
11 hsa-miR-340-5p AHCYL2 1.09 0 -0.11 0.19404 mirMAP -0.18 0 NA
12 hsa-miR-340-5p AHR 1.09 0 -0.98 0 mirMAP -0.2 0 NA
13 hsa-miR-340-5p AK3 1.09 0 -0.93 0 MirTarget -0.13 0 NA
14 hsa-miR-340-5p AKAP2 1.09 0 -2.14 0 mirMAP -0.34 0 NA
15 hsa-miR-340-5p AKT3 1.09 0 -1.39 0 mirMAP -0.28 0 NA
16 hsa-miR-340-5p ALCAM 1.09 0 0.51 0.00106 MirTarget -0.21 1.0E-5 NA
17 hsa-miR-340-5p ALKBH8 1.09 0 -0.38 0 mirMAP -0.22 0 NA
18 hsa-miR-340-5p ALPK3 1.09 0 -1.48 0 mirMAP -0.2 0 NA
19 hsa-miR-340-5p ALS2 1.09 0 -0.23 3.0E-5 MirTarget -0.12 0 NA
20 hsa-miR-340-5p ALX4 1.09 0 -3.22 0 mirMAP -0.34 8.0E-5 NA
21 hsa-miR-340-5p AMOT 1.09 0 -0.91 0 miRNAWalker2 validate; mirMAP -0.19 0 NA
22 hsa-miR-340-5p AMOTL1 1.09 0 -1.81 0 mirMAP -0.22 0 NA
23 hsa-miR-340-5p ANKH 1.09 0 -0.31 0.00327 mirMAP -0.13 5.0E-5 NA
24 hsa-miR-340-5p ANKRD26 1.09 0 -0.11 0.24936 mirMAP -0.16 0 NA
25 hsa-miR-340-5p ANKRD28 1.09 0 -0.1 0.1268 MirTarget; miRNATAP -0.16 0 NA
26 hsa-miR-340-5p ANKRD29 1.09 0 -2.95 0 miRNAWalker2 validate; MirTarget; mirMAP -0.38 0 NA
27 hsa-miR-340-5p ANKRD40 1.09 0 -0.79 0 miRNAWalker2 validate; mirMAP -0.22 0 NA
28 hsa-miR-340-5p ANO6 1.09 0 -1.5 0 mirMAP -0.32 0 NA
29 hsa-miR-340-5p ANTXR2 1.09 0 -1.7 0 mirMAP -0.26 0 NA
30 hsa-miR-340-5p APBB2 1.09 0 -0.39 0.0002 mirMAP -0.21 0 NA
31 hsa-miR-340-5p APH1B 1.09 0 -0.54 0 mirMAP -0.23 0 NA
32 hsa-miR-340-5p APLN 1.09 0 0.04 0.75786 MirTarget; miRNATAP -0.11 0.0174 NA
33 hsa-miR-340-5p APPBP2 1.09 0 -0.25 0.00343 MirTarget -0.2 0 NA
34 hsa-miR-340-5p APPL1 1.09 0 -0.29 1.0E-5 miRNAWalker2 validate; MirTarget -0.18 0 NA
35 hsa-miR-340-5p AQP4 1.09 0 -2.95 0 mirMAP -0.33 3.0E-5 NA
36 hsa-miR-340-5p AR 1.09 0 -1 0.00094 mirMAP -0.59 0 NA
37 hsa-miR-340-5p ARHGAP12 1.09 0 -0.58 0 miRNAWalker2 validate -0.19 0 NA
38 hsa-miR-340-5p ARHGAP19 1.09 0 -0.97 0 mirMAP -0.18 0 NA
39 hsa-miR-340-5p ARHGAP24 1.09 0 -1.41 0 mirMAP -0.15 1.0E-5 NA
40 hsa-miR-340-5p ARHGAP26 1.09 0 -1.51 0 mirMAP -0.21 0 NA
41 hsa-miR-340-5p ARHGAP32 1.09 0 0.43 9.0E-5 mirMAP -0.2 0 NA
42 hsa-miR-340-5p ARHGAP6 1.09 0 -1.65 0 mirMAP -0.21 0 NA
43 hsa-miR-340-5p ARHGEF6 1.09 0 -1.7 0 MirTarget -0.27 0 NA
44 hsa-miR-340-5p ARID1B 1.09 0 -0.39 0 MirTarget -0.12 0 NA
45 hsa-miR-340-5p ARID2 1.09 0 0.01 0.8705 MirTarget -0.16 0 NA
46 hsa-miR-340-5p ARL10 1.09 0 -1.27 0 mirMAP -0.28 0 NA
47 hsa-miR-340-5p ARL13B 1.09 0 -0.46 0 mirMAP -0.19 0 NA
48 hsa-miR-340-5p ARL4A 1.09 0 -1.62 0 mirMAP -0.11 0.0019 NA
49 hsa-miR-340-5p ARL6IP5 1.09 0 -0.45 0 mirMAP -0.1 0 NA
50 hsa-miR-340-5p ARMC8 1.09 0 -0.25 0 MirTarget; mirMAP -0.11 0 NA
51 hsa-miR-340-5p ARPP19 1.09 0 -0.25 0.00027 mirMAP -0.18 0 NA
52 hsa-miR-340-5p ASXL3 1.09 0 -2.86 0 mirMAP -0.45 0 NA
53 hsa-miR-340-5p ATF1 1.09 0 -0.23 3.0E-5 MirTarget -0.1 0 NA
54 hsa-miR-340-5p ATP11B 1.09 0 -0.93 0 mirMAP -0.11 0.00211 NA
55 hsa-miR-340-5p ATP2B4 1.09 0 -1.11 0 mirMAP -0.23 0 NA
56 hsa-miR-340-5p ATP7A 1.09 0 -0.47 0 mirMAP -0.2 0 NA
57 hsa-miR-340-5p ATP8B1 1.09 0 0.58 0 MirTarget -0.23 0 NA
58 hsa-miR-340-5p ATXN1L 1.09 0 -0.97 0 mirMAP -0.23 0 NA
59 hsa-miR-340-5p AVL9 1.09 0 0.23 0.01367 mirMAP -0.14 0 NA
60 hsa-miR-340-5p BACE1 1.09 0 -0.67 0 mirMAP -0.19 0 NA
61 hsa-miR-340-5p BBS10 1.09 0 -0.8 0 miRNAWalker2 validate; mirMAP -0.24 0 NA
62 hsa-miR-340-5p BBS7 1.09 0 -0.61 0 mirMAP -0.13 0 NA
63 hsa-miR-340-5p BBX 1.09 0 -0.61 0 mirMAP -0.22 0 NA
64 hsa-miR-340-5p BCKDHB 1.09 0 -0.64 0 mirMAP -0.13 0 NA
65 hsa-miR-340-5p BCLAF1 1.09 0 -0.27 1.0E-5 mirMAP -0.15 0 NA
66 hsa-miR-340-5p BCOR 1.09 0 0.37 2.0E-5 MirTarget -0.12 1.0E-5 NA
67 hsa-miR-340-5p BEND7 1.09 0 -1.72 0 mirMAP -0.14 0.0192 NA
68 hsa-miR-340-5p BIVM 1.09 0 -0.67 0 miRNAWalker2 validate -0.15 0 NA
69 hsa-miR-340-5p BMP5 1.09 0 -4.21 0 mirMAP -0.3 0.0042 NA
70 hsa-miR-340-5p BMPR1A 1.09 0 -0.75 0 MirTarget -0.21 0 NA
71 hsa-miR-340-5p BMPR2 1.09 0 -0.62 0 mirMAP -0.23 0 NA
72 hsa-miR-340-5p BMX 1.09 0 -3.75 0 MirTarget -0.33 2.0E-5 NA
73 hsa-miR-340-5p BNC2 1.09 0 -0.78 0 mirMAP -0.24 0 NA
74 hsa-miR-340-5p BNIP2 1.09 0 -0.8 0 MirTarget -0.1 0 NA
75 hsa-miR-340-5p BTC 1.09 0 -1.19 0 mirMAP -0.24 0.00018 NA
76 hsa-miR-340-5p BVES 1.09 0 -1.62 0 MirTarget -0.22 0 NA
77 hsa-miR-340-5p C16orf45 1.09 0 -0.55 0.00106 mirMAP -0.22 3.0E-5 NA
78 hsa-miR-340-5p C1QTNF3 1.09 0 0.57 0.00057 MirTarget -0.15 0.00335 NA
79 hsa-miR-340-5p C21orf91 1.09 0 -0.78 0 mirMAP -0.11 0.00076 NA
80 hsa-miR-340-5p C3orf58 1.09 0 -1.12 0 miRNATAP -0.13 0.00051 NA
81 hsa-miR-340-5p C3orf70 1.09 0 -0.82 0 mirMAP -0.16 0.00041 NA
82 hsa-miR-340-5p C4orf32 1.09 0 -0.94 0 mirMAP -0.24 0 NA
83 hsa-miR-340-5p C4orf36 1.09 0 -0.43 0.00053 mirMAP -0.25 0 NA
84 hsa-miR-340-5p C5orf30 1.09 0 0.37 0.00227 mirMAP -0.12 0.0015 NA
85 hsa-miR-340-5p CACNB2 1.09 0 -0.73 2.0E-5 miRNATAP -0.28 0 NA
86 hsa-miR-340-5p CACNB4 1.09 0 -1.55 0 mirMAP -0.16 0.00215 NA
87 hsa-miR-340-5p CADM2 1.09 0 -2.4 0 MirTarget -0.44 0 NA
88 hsa-miR-340-5p CAPN7 1.09 0 -0.37 0 MirTarget -0.19 0 NA
89 hsa-miR-340-5p CASC4 1.09 0 -0.15 0.04292 MirTarget -0.19 0 NA
90 hsa-miR-340-5p CASK 1.09 0 0.23 0.00547 mirMAP -0.1 5.0E-5 NA
91 hsa-miR-340-5p CAST 1.09 0 -0.6 0 miRNATAP -0.16 0 NA
92 hsa-miR-340-5p CAV1 1.09 0 -3.35 0 MirTarget -0.38 0 NA
93 hsa-miR-340-5p CBR4 1.09 0 -0.13 0.12049 MirTarget -0.13 0 NA
94 hsa-miR-340-5p CCDC126 1.09 0 -0.21 0.03155 mirMAP -0.14 1.0E-5 NA
95 hsa-miR-340-5p CCDC146 1.09 0 -0.44 3.0E-5 MirTarget -0.1 0.00148 NA
96 hsa-miR-340-5p CCDC47 1.09 0 0.15 0.05931 miRNATAP -0.14 0 NA
97 hsa-miR-340-5p CCDC50 1.09 0 -1.33 0 mirMAP -0.16 0 NA
98 hsa-miR-340-5p CCDC82 1.09 0 -1.57 0 MirTarget -0.1 0.00514 NA
99 hsa-miR-340-5p CCL28 1.09 0 -3.13 0 mirMAP -0.17 0.0367 NA
100 hsa-miR-340-5p CCND1 1.09 0 0.79 0 mirMAP -0.16 0.00211 NA
101 hsa-miR-340-5p CCNG2 1.09 0 -0.15 0.14084 MirTarget; mirMAP -0.16 0 27374211 MicroRNA 340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2; Notably alteration of miR-340 expression affected the luciferase activity of wild-type 3'-UTR of cyclin G2 CCNG2 and regulated CCNG2 abundance in gastric cancer cells indicating that CCNG2 is a direct target of miR-340; Moreover CCNG2 knockdown eradicated the effects of miR-340 silencing on gastric cancer cells
102 hsa-miR-340-5p CCNT2 1.09 0 -0.29 3.0E-5 mirMAP -0.11 0 NA
103 hsa-miR-340-5p CCPG1 1.09 0 -0.53 0 MirTarget -0.24 0 NA
104 hsa-miR-340-5p CD209 1.09 0 -2.69 0 mirMAP -0.19 0.00306 NA
105 hsa-miR-340-5p CD2AP 1.09 0 0.26 0.00079 mirMAP -0.13 0 NA
106 hsa-miR-340-5p CD302 1.09 0 -1.77 0 mirMAP -0.22 0 NA
107 hsa-miR-340-5p CD44 1.09 0 0.06 0.57241 mirMAP -0.12 0.00089 NA
108 hsa-miR-340-5p CD46 1.09 0 0.22 0.00794 miRNAWalker2 validate; mirMAP -0.15 0 NA
109 hsa-miR-340-5p CD47 1.09 0 -0.45 0 miRNATAP -0.12 0 NA
110 hsa-miR-340-5p CD93 1.09 0 -1.1 0 mirMAP -0.19 0 NA
111 hsa-miR-340-5p CDC42EP3 1.09 0 -1.06 0 mirMAP -0.16 3.0E-5 NA
112 hsa-miR-340-5p CDH12 1.09 0 -1.96 0 MirTarget -0.23 9.0E-5 NA
113 hsa-miR-340-5p CDH6 1.09 0 -0.97 0 mirMAP -0.25 0 NA
114 hsa-miR-340-5p CDH8 1.09 0 -1.56 0 mirMAP -0.43 0 NA
115 hsa-miR-340-5p CDK12 1.09 0 0.2 0.04665 mirMAP -0.12 0.0002 NA
116 hsa-miR-340-5p CDK6 1.09 0 -1.03 0 mirMAP -0.12 0.01354 NA
117 hsa-miR-340-5p CDON 1.09 0 -0.99 0 MirTarget -0.37 0 NA
118 hsa-miR-340-5p CDYL2 1.09 0 0.31 0.04236 mirMAP -0.25 0 NA
119 hsa-miR-340-5p CEP120 1.09 0 -0.64 0 miRNATAP -0.18 0 NA
120 hsa-miR-340-5p CEP290 1.09 0 -0.22 0.01345 MirTarget -0.18 0 NA
121 hsa-miR-340-5p CEP57 1.09 0 -0.46 0 MirTarget -0.11 0 NA
122 hsa-miR-340-5p CEP68 1.09 0 -1.32 0 MirTarget -0.21 0 NA
123 hsa-miR-340-5p CEP97 1.09 0 0.06 0.59549 mirMAP -0.23 0 NA
124 hsa-miR-340-5p CHD6 1.09 0 -0.27 0.00287 mirMAP -0.19 0 NA
125 hsa-miR-340-5p CHD9 1.09 0 -1.21 0 mirMAP -0.34 0 NA
126 hsa-miR-340-5p CHL1 1.09 0 -4.19 0 mirMAP -0.55 0 NA
127 hsa-miR-340-5p CHM 1.09 0 -0.44 0 mirMAP -0.23 0 NA
128 hsa-miR-340-5p CLDN8 1.09 0 -2.41 0 MirTarget -0.25 0.01122 NA
129 hsa-miR-340-5p CLIC4 1.09 0 -0.6 0 MirTarget -0.13 0 NA
130 hsa-miR-340-5p CLIP1 1.09 0 -0.42 0 mirMAP -0.17 0 NA
131 hsa-miR-340-5p CLIP4 1.09 0 -2.32 0 MirTarget -0.24 1.0E-5 NA
132 hsa-miR-340-5p CLMN 1.09 0 -0.54 0 mirMAP -0.1 0.00161 NA
133 hsa-miR-340-5p CLOCK 1.09 0 -0.44 0.00109 MirTarget; mirMAP -0.29 0 NA
134 hsa-miR-340-5p CMTM6 1.09 0 0.13 0.07841 mirMAP -0.13 0 NA
135 hsa-miR-340-5p CNKSR2 1.09 0 -3.5 0 mirMAP; miRNATAP -0.25 0.00122 NA
136 hsa-miR-340-5p CNOT4 1.09 0 -0.16 0.001 mirMAP -0.1 0 NA
137 hsa-miR-340-5p CNRIP1 1.09 0 -1.67 0 mirMAP -0.17 0 NA
138 hsa-miR-340-5p CNTN4 1.09 0 -1.68 0 mirMAP -0.44 0 NA
139 hsa-miR-340-5p COBLL1 1.09 0 -1.51 0 mirMAP -0.32 0 NA
140 hsa-miR-340-5p COG6 1.09 0 -0.3 3.0E-5 mirMAP -0.19 0 NA
141 hsa-miR-340-5p COL4A3BP 1.09 0 -1.02 0 MirTarget -0.25 0 NA
142 hsa-miR-340-5p CPD 1.09 0 -0.24 0.02078 mirMAP -0.24 0 NA
143 hsa-miR-340-5p CPEB3 1.09 0 -0.8 0 mirMAP -0.25 0 NA
144 hsa-miR-340-5p CPM 1.09 0 -1.87 0 mirMAP -0.19 2.0E-5 NA
145 hsa-miR-340-5p CREB1 1.09 0 -0.39 0 MirTarget -0.14 0 NA
146 hsa-miR-340-5p CREB5 1.09 0 -2.35 0 mirMAP -0.29 0 NA
147 hsa-miR-340-5p CRY2 1.09 0 -1.2 0 miRNAWalker2 validate -0.2 0 NA
148 hsa-miR-340-5p CRYZ 1.09 0 -0.15 0.08389 mirMAP -0.12 1.0E-5 NA
149 hsa-miR-340-5p CSDE1 1.09 0 -0.7 0 miRNAWalker2 validate; mirMAP; miRNATAP -0.12 0 NA
150 hsa-miR-340-5p CSRNP3 1.09 0 -3.02 0 mirMAP -0.63 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF GENE EXPRESSION 119 1733 2.6e-10 1.21e-06
2 REGULATION OF CELL DIFFERENTIATION 104 1492 1.875e-09 4.363e-06
3 INTRACELLULAR SIGNAL TRANSDUCTION 106 1572 7.752e-09 8e-06
4 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 111 1672 7.674e-09 8e-06
5 CELL DEVELOPMENT 98 1426 1.203e-08 8e-06
6 TISSUE DEVELOPMENT 103 1518 9.436e-09 8e-06
7 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 116 1784 1.079e-08 8e-06
8 REGULATION OF GTPASE ACTIVITY 57 673 2.086e-08 1.213e-05
9 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 115 1805 3.853e-08 1.992e-05
10 CELL GROWTH 21 135 4.854e-08 2.258e-05
11 CARDIOVASCULAR SYSTEM DEVELOPMENT 62 788 7.434e-08 2.882e-05
12 CIRCULATORY SYSTEM DEVELOPMENT 62 788 7.434e-08 2.882e-05
13 CELL PROJECTION ORGANIZATION 68 902 8.753e-08 3.133e-05
14 LOCOMOTION 79 1114 1.004e-07 3.336e-05
15 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 73 1008 1.413e-07 4.383e-05
16 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 105 1656 2.095e-07 5.416e-05
17 GROWTH 39 410 2.036e-07 5.416e-05
18 RESPONSE TO GROWTH FACTOR 43 475 1.945e-07 5.416e-05
19 DEVELOPMENTAL GROWTH 34 333 2.379e-07 5.827e-05
20 TISSUE MORPHOGENESIS 46 533 2.917e-07 5.942e-05
21 POSITIVE REGULATION OF MOLECULAR FUNCTION 111 1791 2.836e-07 5.942e-05
22 NEUROGENESIS 92 1402 2.937e-07 5.942e-05
23 REGULATION OF CELL DEVELOPMENT 63 836 2.709e-07 5.942e-05
24 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 58 750 3.535e-07 6.854e-05
25 REGULATION OF TRANSPORT 111 1804 4.065e-07 7.566e-05
26 PROTEIN PHOSPHORYLATION 68 944 4.717e-07 8.442e-05
27 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 44 513 6.274e-07 0.0001081
28 RESPONSE TO ENDOGENOUS STIMULUS 93 1450 6.902e-07 0.0001147
29 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 78 1152 7.719e-07 0.0001239
30 REGULATION OF NEURON DIFFERENTIATION 46 554 8.666e-07 0.0001263
31 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 84 1275 8.64e-07 0.0001263
32 REGULATION OF CELLULAR COMPONENT MOVEMENT 58 771 8.686e-07 0.0001263
33 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 70 1004 1.046e-06 0.0001475
34 CELL PART MORPHOGENESIS 50 633 1.26e-06 0.0001629
35 REGULATION OF HYDROLASE ACTIVITY 86 1327 1.243e-06 0.0001629
36 DEVELOPMENTAL CELL GROWTH 14 77 1.216e-06 0.0001629
37 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 53 689 1.344e-06 0.000169
38 REGULATION OF CIRCADIAN RHYTHM 16 103 1.93e-06 0.0002363
39 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 76 1142 2.062e-06 0.000246
40 NEURON PROJECTION MORPHOGENESIS 36 402 2.469e-06 0.0002872
41 POSITIVE REGULATION OF CATALYTIC ACTIVITY 94 1518 2.705e-06 0.0003052
42 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 19 144 2.755e-06 0.0003052
43 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 66 957 3.118e-06 0.0003311
44 HEAD DEVELOPMENT 53 709 3.131e-06 0.0003311
45 CELLULAR COMPONENT MORPHOGENESIS 63 900 3.263e-06 0.0003374
46 NEURON PROJECTION EXTENSION 11 53 4.402e-06 0.0004358
47 REGULATION OF CELLULAR PROTEIN LOCALIZATION 44 552 4.357e-06 0.0004358
48 POSITIVE REGULATION OF CELL PROLIFERATION 58 814 4.743e-06 0.0004504
49 RHYTHMIC PROCESS 29 298 4.722e-06 0.0004504
50 CIRCADIAN RHYTHM 18 137 5.324e-06 0.0004955
51 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 33 368 6.259e-06 0.000571
52 NEURON PROJECTION DEVELOPMENT 43 545 7.222e-06 0.0006356
53 REGULATION OF PHOSPHORUS METABOLIC PROCESS 97 1618 7.24e-06 0.0006356
54 REGULATION OF CELL MATRIX ADHESION 14 90 8.247e-06 0.0007106
55 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 27 278 1.034e-05 0.0008588
56 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 15 104 1.023e-05 0.0008588
57 REGULATION OF CELL SIZE 20 172 1.069e-05 0.000873
58 NEURON DEVELOPMENT 50 687 1.234e-05 0.0009899
59 REGULATION OF CELL PROLIFERATION 90 1496 1.401e-05 0.001105
60 POSITIVE REGULATION OF LOCOMOTION 35 420 1.631e-05 0.001224
61 SKELETAL SYSTEM DEVELOPMENT 37 455 1.618e-05 0.001224
62 REGULATION OF EPITHELIAL CELL PROLIFERATION 27 285 1.622e-05 0.001224
63 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 16 122 1.795e-05 0.001326
64 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 30 337 1.882e-05 0.001347
65 REGULATION OF CELLULAR COMPONENT SIZE 30 337 1.882e-05 0.001347
66 CELL MOTILITY 57 835 2.006e-05 0.001393
67 LOCALIZATION OF CELL 57 835 2.006e-05 0.001393
68 NEGATIVE REGULATION OF CELL DIFFERENTIATION 45 609 2.32e-05 0.001587
69 PROTEIN UBIQUITINATION 46 629 2.438e-05 0.001597
70 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 55 801 2.388e-05 0.001597
71 REGULATION OF CELL ADHESION 46 629 2.438e-05 0.001597
72 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 18 154 2.717e-05 0.001688
73 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 84 1395 2.686e-05 0.001688
74 HEART DEVELOPMENT 37 466 2.72e-05 0.001688
75 PHOSPHORYLATION 76 1228 2.687e-05 0.001688
76 EPITHELIUM DEVELOPMENT 62 945 2.873e-05 0.001759
77 NEGATIVE REGULATION OF CELL COMMUNICATION 74 1192 3.115e-05 0.001882
78 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 22 218 3.734e-05 0.002228
79 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 66 1036 3.918e-05 0.002269
80 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 89 1517 3.998e-05 0.002269
81 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 66 1036 3.918e-05 0.002269
82 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 14 103 3.96e-05 0.002269
83 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 22 220 4.291e-05 0.002406
84 ORGAN MORPHOGENESIS 56 841 4.713e-05 0.002611
85 REGULATION OF NEURON PROJECTION DEVELOPMENT 33 408 5.101e-05 0.002792
86 ORGAN GROWTH 11 68 5.24e-05 0.002835
87 REGULATION OF DEVELOPMENTAL GROWTH 26 289 5.581e-05 0.002918
88 REGULATION OF CELLULAR COMPONENT BIOGENESIS 52 767 5.544e-05 0.002918
89 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 81 1360 5.49e-05 0.002918
90 REGULATION OF OSSIFICATION 19 178 5.829e-05 0.003014
91 EMBRYONIC MORPHOGENESIS 40 539 5.955e-05 0.003045
92 REGULATION OF CELL PROJECTION ORGANIZATION 41 558 6.029e-05 0.003049
93 REGULATION OF PROTEIN MODIFICATION PROCESS 97 1710 6.417e-05 0.003177
94 GLAND DEVELOPMENT 32 395 6.401e-05 0.003177
95 MUSCLE TISSUE DEVELOPMENT 25 275 6.511e-05 0.003189
96 AXON EXTENSION 8 37 6.601e-05 0.0032
97 CENTRAL NERVOUS SYSTEM DEVELOPMENT 57 872 6.691e-05 0.00321
98 MUSCLE STRUCTURE DEVELOPMENT 34 432 6.786e-05 0.003222
99 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 57 873 6.902e-05 0.003244
100 EMBRYO DEVELOPMENT 58 894 7.099e-05 0.003247
101 VASCULATURE DEVELOPMENT 36 469 6.999e-05 0.003247
102 NEURON DIFFERENTIATION 57 874 7.119e-05 0.003247
103 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 31 381 7.652e-05 0.003457
104 MORPHOGENESIS OF AN EPITHELIUM 32 400 8.116e-05 0.003631
105 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 12 84 8.529e-05 0.00378
106 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 47 684 9.166e-05 0.004023
107 POSITIVE REGULATION OF CELL DIFFERENTIATION 54 823 9.434e-05 0.004103
108 PALATE DEVELOPMENT 12 85 9.589e-05 0.004131
109 TUBE DEVELOPMENT 40 552 9.968e-05 0.004141
110 UROGENITAL SYSTEM DEVELOPMENT 26 299 9.795e-05 0.004141
111 NEGATIVE CHEMOTAXIS 8 39 9.829e-05 0.004141
112 REGULATION OF CELL MORPHOGENESIS 40 552 9.968e-05 0.004141
113 NEGATIVE REGULATION OF ORGAN GROWTH 6 21 0.0001047 0.004313
114 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 37 498 0.000109 0.00445
115 PROTEIN LOCALIZATION 100 1805 0.0001198 0.004848
116 STRIATED MUSCLE CELL DIFFERENTIATION 18 173 0.0001257 0.005043
117 MUSCLE CELL DIFFERENTIATION 22 237 0.0001296 0.005156
118 FOREBRAIN DEVELOPMENT 29 357 0.0001327 0.005187
119 NEURON PROJECTION GUIDANCE 20 205 0.0001323 0.005187
120 PROTEIN CATABOLIC PROCESS 41 579 0.0001348 0.005228
121 SECOND MESSENGER MEDIATED SIGNALING 17 160 0.0001488 0.005721
122 CELLULAR MACROMOLECULE LOCALIZATION 73 1234 0.0001598 0.006043
123 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 49 740 0.0001595 0.006043
124 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 107 1977 0.0001676 0.006288
125 DENDRITE MORPHOGENESIS 8 42 0.0001703 0.00634
126 REGULATION OF ANATOMICAL STRUCTURE SIZE 35 472 0.0001722 0.006359
127 POSITIVE REGULATION OF HYDROLASE ACTIVITY 57 905 0.0001785 0.006541
128 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 101 1848 0.0001827 0.00664
129 BLOOD VESSEL MORPHOGENESIS 29 364 0.000185 0.006673
130 SENSORY ORGAN DEVELOPMENT 36 493 0.0001887 0.006754
131 REGULATION OF PROTEIN LOCALIZATION 59 950 0.0001996 0.007088
132 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 39 554 0.0002198 0.007689
133 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 15 135 0.0002194 0.007689
134 REGULATION OF CELL JUNCTION ASSEMBLY 10 68 0.0002573 0.008738
135 REGULATION OF PROTEIN IMPORT 18 183 0.0002548 0.008738
136 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 62 1021 0.0002529 0.008738
137 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 10 68 0.0002573 0.008738
138 TAXIS 34 464 0.0002645 0.008917
139 REGULATION OF CYTOSKELETON ORGANIZATION 36 502 0.0002672 0.008944
140 PALLIUM DEVELOPMENT 16 153 0.0002767 0.009179
141 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 60 983 0.0002781 0.009179
142 CIRCADIAN REGULATION OF GENE EXPRESSION 9 57 0.0003011 0.009867
143 CELLULAR RESPONSE TO STRESS 87 1565 0.0003067 0.009981
NumGOOverlapSizeP ValueAdj. P Value
1 MOLECULAR FUNCTION REGULATOR 90 1353 2.213e-07 0.0001028
2 ENZYME BINDING 109 1737 1.996e-07 0.0001028
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 78 1199 3.517e-06 0.001089
4 ENZYME REGULATOR ACTIVITY 65 959 6.542e-06 0.001519
5 NUCLEOSIDE TRIPHOSPHATASE REGULATOR ACTIVITY 30 329 1.184e-05 0.0022
6 ENZYME ACTIVATOR ACTIVITY 38 471 1.489e-05 0.002305
7 PROTEIN KINASE ACTIVITY 47 640 1.791e-05 0.002377
8 KINASE ACTIVITY 57 842 2.542e-05 0.002624
9 PROTEIN SERINE THREONINE KINASE ACTIVITY 36 445 2.346e-05 0.002624
10 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 34 420 3.875e-05 0.0036
11 PHOSPHATASE BINDING 18 162 5.354e-05 0.004145
12 DOUBLE STRANDED DNA BINDING 52 764 5.01e-05 0.004145
13 SEQUENCE SPECIFIC DNA BINDING 64 1037 0.0001282 0.009162
14 CYTOSKELETAL PROTEIN BINDING 53 819 0.0001547 0.009582
15 REGULATORY REGION NUCLEIC ACID BINDING 53 818 0.0001501 0.009582
NumGOOverlapSizeP ValueAdj. P Value
1 CELL PROJECTION 118 1786 3.129e-09 1.828e-06
2 PLASMA MEMBRANE REGION 68 929 2.63e-07 7.681e-05
3 MEMBRANE REGION 78 1134 4.163e-07 8.104e-05
4 CYTOSKELETON 117 1967 1.052e-06 0.0001536
5 CENTROSOME 41 487 2.421e-06 0.0002827
6 NEURON PART 81 1265 4.113e-06 0.0004003
7 CELL LEADING EDGE 32 350 5.781e-06 0.0004823
8 NEURON PROJECTION 64 942 7.159e-06 0.0005226
9 APICAL JUNCTION COMPLEX 17 128 8.345e-06 0.0005415
10 GOLGI APPARATUS 88 1445 1.109e-05 0.0006477
11 CELL PROJECTION PART 63 946 1.572e-05 0.0008345
12 SYNAPSE 53 754 1.784e-05 0.0008681
13 CELL JUNCTION 71 1151 5.544e-05 0.00249
14 EXCITATORY SYNAPSE 20 197 7.64e-05 0.003187
15 RUFFLE 17 156 0.000109 0.004243
16 APICAL PART OF CELL 29 361 0.0001607 0.005637
17 MICROTUBULE ORGANIZING CENTER 43 623 0.0001641 0.005637
18 CELL CELL JUNCTION 30 383 0.0001939 0.006132
19 SYNAPTIC MEMBRANE 23 261 0.0001995 0.006132
20 CELL SURFACE 49 757 0.0002709 0.007912
21 LAMELLIPODIUM 17 172 0.0003536 0.009834

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 20 163 4.725e-06 0.0002457
2 Cellular_senescence_hsa04218 18 160 4.541e-05 0.001181
3 Apelin_signaling_pathway_hsa04371 16 137 7.56e-05 0.00131
4 Focal_adhesion_hsa04510 19 199 0.0002549 0.003314
5 TGF_beta_signaling_pathway_hsa04350 11 84 0.0003638 0.003784
6 Gap_junction_hsa04540 11 88 0.0005457 0.00473
7 Hippo_signaling_pathway_hsa04390 15 154 0.0008959 0.006656
8 Autophagy_animal_hsa04140 13 128 0.001316 0.008557
9 FoxO_signaling_pathway_hsa04068 13 132 0.001742 0.01007
10 MAPK_signaling_pathway_hsa04010 22 295 0.002448 0.01273
11 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 0.002758 0.01304
12 Phosphatidylinositol_signaling_system_hsa04070 10 99 0.004761 0.02063
13 mTOR_signaling_pathway_hsa04150 13 151 0.005592 0.02237
14 Tight_junction_hsa04530 14 170 0.006092 0.02263
15 Regulation_of_actin_cytoskeleton_hsa04810 16 208 0.00674 0.02336
16 Oocyte_meiosis_hsa04114 11 124 0.008346 0.02713
17 Hedgehog_signaling_pathway_hsa04340 6 47 0.008885 0.02718
18 PI3K_Akt_signaling_pathway_hsa04151 23 352 0.009691 0.028
19 Wnt_signaling_pathway_hsa04310 12 146 0.0108 0.02955
20 AMPK_signaling_pathway_hsa04152 10 121 0.01834 0.04769
21 Calcium_signaling_pathway_hsa04020 13 182 0.02385 0.05907
22 Sphingolipid_signaling_pathway_hsa04071 9 118 0.03833 0.0906
23 p53_signaling_pathway_hsa04115 6 68 0.04635 0.1048
24 Endocytosis_hsa04144 15 244 0.05055 0.1095
25 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.05349 0.1113
26 Adherens_junction_hsa04520 6 72 0.05833 0.1167
27 VEGF_signaling_pathway_hsa04370 5 59 0.07593 0.1462
28 Jak_STAT_signaling_pathway_hsa04630 10 162 0.09554 0.1714
29 ECM_receptor_interaction_hsa04512 6 82 0.09564 0.1714
30 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.0989 0.1714
31 ErbB_signaling_pathway_hsa04012 6 85 0.1088 0.1826
32 Cytokine_cytokine_receptor_interaction_hsa04060 14 270 0.1593 0.2588
33 Rap1_signaling_pathway_hsa04015 11 206 0.1712 0.2698
34 Ras_signaling_pathway_hsa04014 12 232 0.1842 0.2818
35 Phospholipase_D_signaling_pathway_hsa04072 8 146 0.2006 0.298
36 Mitophagy_animal_hsa04137 4 65 0.2399 0.3466
37 HIF_1_signaling_pathway_hsa04066 5 100 0.3402 0.4685
38 Cell_cycle_hsa04110 6 124 0.3424 0.4685
39 cAMP_signaling_pathway_hsa04024 9 198 0.3522 0.4697
40 Peroxisome_hsa04146 4 83 0.3964 0.5093
41 TNF_signaling_pathway_hsa04668 5 108 0.4016 0.5093
42 Apoptosis_hsa04210 6 138 0.4388 0.5433
43 ABC_transporters_hsa02010 2 45 0.5207 0.629
44 Phagosome_hsa04145 6 152 0.5323 0.629
45 Notch_signaling_pathway_hsa04330 2 48 0.5557 0.6422
46 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.8849 0.979
47 Necroptosis_hsa04217 3 164 0.954 1
48 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.9588 1

Quest ID: f16c845980020eabbeab4cc5e9856be6