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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-107 ABCA6 -0.07 0.96422 -0.01 0.97622 miRanda -0.78 0.00096 NA
2 hsa-miR-107 ABI2 -0.07 0.96422 -0.12 0.8703 miRanda -0.12 0.02139 NA
3 hsa-miR-107 ABI3BP -0.07 0.96422 -0.37 0.41633 miRanda -0.77 0.00053 NA
4 hsa-miR-338-3p ABI3BP 0.26 0.82352 -0.37 0.41633 miRanda -0.34 0.00054 NA
5 hsa-miR-107 ABL2 -0.07 0.96422 0.04 0.95748 MirTarget; PITA; miRanda; miRNATAP -0.15 0.0065 NA
6 hsa-miR-107 ACACB -0.07 0.96422 -0.08 0.89068 miRanda -0.41 0.00057 NA
7 hsa-miR-107 ACTG2 -0.07 0.96422 -0.09 0.92216 miRanda -1.78 0 NA
8 hsa-miR-107 ACVR1 -0.07 0.96422 -0.02 0.98204 miRanda -0.11 0.02024 NA
9 hsa-miR-107 ACVR2B -0.07 0.96422 -0.2 0.71234 PITA; miRNATAP -0.24 0.00172 NA
10 hsa-miR-338-3p ADAM11 0.26 0.82352 0.11 0.80369 mirMAP -0.2 0.01167 NA
11 hsa-miR-107 ADAMTS1 -0.07 0.96422 0.03 0.96886 miRanda -0.37 0.00449 NA
12 hsa-miR-338-3p ADAMTS1 0.26 0.82352 0.03 0.96886 miRanda -0.13 0.01943 NA
13 hsa-miR-107 ADAMTS19 -0.07 0.96422 1.17 0.10747 miRanda -0.83 0.00455 NA
14 hsa-miR-107 ADAMTS3 -0.07 0.96422 -0.15 0.57772 miRanda -0.46 0.00107 NA
15 hsa-miR-338-3p ADAMTS6 0.26 0.82352 0.02 0.94873 miRNATAP -0.16 0.01117 NA
16 hsa-miR-107 ADAMTSL1 -0.07 0.96422 -0.22 0.5533 miRanda -0.56 0.00121 NA
17 hsa-miR-107 ADAMTSL3 -0.07 0.96422 -0.2 0.64161 MirTarget; PITA; miRanda; miRNATAP -1.21 0 NA
18 hsa-miR-107 ADCY4 -0.07 0.96422 0.26 0.45422 miRanda -0.33 0.00187 NA
19 hsa-miR-107 ADCYAP1 -0.07 0.96422 0.13 0.79662 MirTarget; PITA; miRanda; miRNATAP -1.29 0 NA
20 hsa-miR-107 ADD2 -0.07 0.96422 -0.16 0.76694 miRNAWalker2 validate; miRNATAP -0.98 5.0E-5 NA
21 hsa-miR-107 ADNP -0.07 0.96422 -0.13 0.89598 miRanda -0.14 0.02172 NA
22 hsa-miR-107 ADRB2 -0.07 0.96422 -0.01 0.98489 miRanda -0.43 0.01913 NA
23 hsa-miR-338-3p ADRB2 0.26 0.82352 -0.01 0.98489 miRanda -0.23 0.0054 NA
24 hsa-miR-338-3p AIF1L 0.26 0.82352 0.17 0.69229 miRanda -0.15 0.0389 NA
25 hsa-miR-107 AKAP12 -0.07 0.96422 0.17 0.82172 miRanda; miRNATAP -0.91 1.0E-5 NA
26 hsa-miR-338-3p AKAP12 0.26 0.82352 0.17 0.82172 miRanda -0.26 0.00378 NA
27 hsa-miR-107 AKAP2 -0.07 0.96422 0.07 0.92 MirTarget; PITA; miRanda; miRNATAP -0.32 0.00722 NA
28 hsa-miR-107 AKAP6 -0.07 0.96422 -0.07 0.82446 miRanda -0.64 0 NA
29 hsa-miR-107 AKT3 -0.07 0.96422 0.06 0.90908 PITA; miRanda -0.55 0.00017 NA
30 hsa-miR-107 ALDH1B1 -0.07 0.96422 0.09 0.93378 miRanda -0.32 0.00056 NA
31 hsa-miR-107 ALPK3 -0.07 0.96422 0.84 0.17219 mirMAP -0.52 0.0174 NA
32 hsa-miR-338-3p AMACR 0.26 0.82352 0.02 0.98492 miRanda -0.15 0.01357 NA
33 hsa-miR-107 AMPH -0.07 0.96422 0.08 0.81124 miRanda -0.57 0.00193 NA
34 hsa-miR-107 AMT -0.07 0.96422 0.09 0.87288 miRanda -0.46 0.02226 NA
35 hsa-miR-107 ANGPTL7 -0.07 0.96422 -0.01 0.99351 miRanda -1.49 0 NA
36 hsa-miR-338-3p ANGPTL7 0.26 0.82352 -0.01 0.99351 miRanda -0.24 0.03118 NA
37 hsa-miR-107 ANKRD6 -0.07 0.96422 0.22 0.43754 miRanda -0.49 0.00034 NA
38 hsa-miR-107 ANTXR1 -0.07 0.96422 -0.05 0.96265 miRanda -0.6 0.00138 NA
39 hsa-miR-107 AP1S2 -0.07 0.96422 0.12 0.80192 PITA; miRanda -0.21 0.02448 NA
40 hsa-miR-338-3p AP1S2 0.26 0.82352 0.12 0.80192 MirTarget; PITA; miRanda -0.12 0.00569 NA
41 hsa-miR-107 AP3B2 -0.07 0.96422 0.36 0.54833 miRanda -1.1 4.0E-5 NA
42 hsa-miR-107 APBA1 -0.07 0.96422 -0.19 0.64004 miRNATAP -0.31 0.01764 NA
43 hsa-miR-338-3p APOLD1 0.26 0.82352 0.35 0.649 miRanda -0.18 0.02782 NA
44 hsa-miR-107 ARHGAP1 -0.07 0.96422 0.03 0.97401 miRanda -0.13 0.00718 NA
45 hsa-miR-107 ARHGAP20 -0.07 0.96422 0.1 0.77766 miRanda -0.53 0.00541 NA
46 hsa-miR-107 ARHGAP24 -0.07 0.96422 -0.03 0.93164 miRanda -0.44 0.00038 NA
47 hsa-miR-338-3p ARHGAP6 0.26 0.82352 -0.42 0.35366 miRanda -0.26 0.00512 NA
48 hsa-miR-107 ARMCX2 -0.07 0.96422 0.29 0.5542 miRanda; miRNATAP -0.8 0 NA
49 hsa-miR-107 ARMCX3 -0.07 0.96422 0.03 0.9666 miRanda -0.23 0.02634 NA
50 hsa-miR-338-3p ARMCX3 0.26 0.82352 0.03 0.9666 MirTarget; PITA; miRanda -0.14 0.00164 NA
51 hsa-miR-338-3p ARSB 0.26 0.82352 -0.08 0.88514 miRanda -0.16 2.0E-5 NA
52 hsa-miR-107 ATL1 -0.07 0.96422 0.03 0.93523 miRanda -0.29 0.00538 NA
53 hsa-miR-338-3p ATL1 0.26 0.82352 0.03 0.93523 miRanda -0.14 0.00195 NA
54 hsa-miR-338-3p ATP10D 0.26 0.82352 -0.06 0.91566 MirTarget; miRanda -0.11 0.01855 NA
55 hsa-miR-107 ATP1B2 -0.07 0.96422 -0.1 0.73974 miRanda; miRNATAP -0.86 0 NA
56 hsa-miR-107 ATP2B4 -0.07 0.96422 -0.13 0.8766 miRanda -0.4 0.0005 NA
57 hsa-miR-338-3p ATRN 0.26 0.82352 -0.46 0.56279 MirTarget; miRanda -0.17 0.00015 NA
58 hsa-miR-107 ATRNL1 -0.07 0.96422 -0.45 0.38984 miRanda -1.39 0 NA
59 hsa-miR-107 ATXN1 -0.07 0.96422 -0.02 0.9752 PITA; miRanda -0.18 0.00973 NA
60 hsa-miR-107 BACE1 -0.07 0.96422 -0.16 0.82465 miRNAWalker2 validate; miRTarBase -0.26 0.0028 NA
61 hsa-miR-107 BACH2 -0.07 0.96422 -0.35 0.26727 MirTarget; PITA; miRNATAP -0.59 0.00091 NA
62 hsa-miR-107 BASP1 -0.07 0.96422 0.06 0.91132 miRanda -0.32 0.03293 NA
63 hsa-miR-107 BBS9 -0.07 0.96422 -0.3 0.50207 miRanda -0.18 0.00884 NA
64 hsa-miR-107 BCL11A -0.07 0.96422 -0.11 0.85575 PITA; miRanda; miRNATAP -0.46 0.00496 NA
65 hsa-miR-338-3p BCL11A 0.26 0.82352 -0.11 0.85575 miRanda -0.22 0.00271 NA
66 hsa-miR-107 BCL2L2 -0.07 0.96422 0 0.99812 miRNATAP -0.13 0.01217 NA
67 hsa-miR-107 BMX -0.07 0.96422 -0.01 0.97533 MirTarget; miRanda; miRNATAP -0.63 0.00422 NA
68 hsa-miR-338-3p BMX 0.26 0.82352 -0.01 0.97533 miRanda -0.26 0.0089 NA
69 hsa-miR-107 BNIP3 -0.07 0.96422 0.24 0.69186 miRanda -0.41 0.04607 NA
70 hsa-miR-338-3p BOC 0.26 0.82352 -0.09 0.87023 miRanda -0.27 0.00091 NA
71 hsa-miR-338-3p BST1 0.26 0.82352 0.23 0.52012 miRanda -0.15 0.03629 NA
72 hsa-miR-107 BTG2 -0.07 0.96422 0.01 0.99517 MirTarget; PITA; miRanda; miRNATAP -0.24 0.0064 NA
73 hsa-miR-338-3p BTN2A2 0.26 0.82352 0.1 0.83527 miRanda -0.1 0.00614 NA
74 hsa-miR-338-3p BVES 0.26 0.82352 0.04 0.90028 miRanda -0.29 3.0E-5 NA
75 hsa-miR-107 C17orf51 -0.07 0.96422 -0.1 0.83489 mirMAP -0.29 0.00377 NA
76 hsa-miR-107 CACNA1B -0.07 0.96422 -0.19 0.77523 miRanda -1.29 0 NA
77 hsa-miR-107 CACNA1C -0.07 0.96422 -0.15 0.80484 miRNATAP -0.64 5.0E-5 NA
78 hsa-miR-107 CACNA2D1 -0.07 0.96422 -0.25 0.60439 PITA; miRanda; miRNATAP -1.17 1.0E-5 NA
79 hsa-miR-338-3p CACNA2D1 0.26 0.82352 -0.25 0.60439 miRanda -0.36 0.00235 NA
80 hsa-miR-107 CACNB4 -0.07 0.96422 0.17 0.63328 miRanda -0.42 0.02147 NA
81 hsa-miR-338-3p CACNB4 0.26 0.82352 0.17 0.63328 PITA; miRanda; miRNATAP -0.3 0.00016 NA
82 hsa-miR-338-3p CADM1 0.26 0.82352 0.14 0.76681 PITA; miRanda -0.23 0.00461 NA
83 hsa-miR-107 CADM2 -0.07 0.96422 0.28 0.70913 miRanda -0.97 1.0E-5 NA
84 hsa-miR-338-3p CADM2 0.26 0.82352 0.28 0.70913 miRanda; miRNATAP -0.26 0.00812 NA
85 hsa-miR-107 CADM3 -0.07 0.96422 -0.11 0.84236 miRanda -1.51 0 NA
86 hsa-miR-338-3p CADM3 0.26 0.82352 -0.11 0.84236 miRanda -0.29 0.03788 NA
87 hsa-miR-107 CALCA -0.07 0.96422 0.95 0.16171 miRanda -1.29 0.00019 NA
88 hsa-miR-107 CALD1 -0.07 0.96422 0.1 0.9298 miRanda -0.66 1.0E-5 NA
89 hsa-miR-338-3p CALD1 0.26 0.82352 0.1 0.9298 miRanda -0.22 0.00082 NA
90 hsa-miR-107 CAP2 -0.07 0.96422 0.28 0.45438 miRanda -0.58 4.0E-5 NA
91 hsa-miR-338-3p CAV1 0.26 0.82352 0.05 0.95242 miRanda -0.21 0.00012 NA
92 hsa-miR-338-3p CBX6 0.26 0.82352 -0.23 0.66338 mirMAP -0.28 6.0E-5 NA
93 hsa-miR-338-3p CCBE1 0.26 0.82352 -0.28 0.58179 miRanda -0.35 0.00191 NA
94 hsa-miR-107 CCDC50 -0.07 0.96422 0.08 0.92311 MirTarget; miRanda; miRNATAP -0.12 0.01008 NA
95 hsa-miR-107 CCDC85A -0.07 0.96422 -0.12 0.7313 miRanda -0.5 0.00318 NA
96 hsa-miR-338-3p CCL21 0.26 0.82352 -0.38 0.60205 miRNATAP -0.3 0.0398 NA
97 hsa-miR-338-3p CD200 0.26 0.82352 -0.12 0.79242 miRanda -0.14 0.03343 NA
98 hsa-miR-107 CD34 -0.07 0.96422 0.15 0.83407 miRanda -0.21 0.02322 NA
99 hsa-miR-338-3p CDC14A 0.26 0.82352 -0.08 0.8497 miRanda -0.12 0.00053 NA
100 hsa-miR-338-3p CDH5 0.26 0.82352 0.01 0.99191 miRanda -0.12 0.01545 NA
101 hsa-miR-107 CDK14 -0.07 0.96422 0.01 0.97664 MirTarget; miRanda; miRNATAP -0.53 0.00109 NA
102 hsa-miR-107 CDKN1C -0.07 0.96422 -0.16 0.74975 miRanda -0.48 0.00088 NA
103 hsa-miR-338-3p CENPBD1 0.26 0.82352 0.13 0.79823 miRanda -0.12 0.00012 NA
104 hsa-miR-107 CEP68 -0.07 0.96422 -0.12 0.86579 miRanda -0.26 6.0E-5 NA
105 hsa-miR-107 CFDP1 -0.07 0.96422 0.02 0.98297 miRanda -0.11 0.04929 NA
106 hsa-miR-107 CHD6 -0.07 0.96422 -0.32 0.69558 PITA; miRanda -0.27 0.00054 NA
107 hsa-miR-107 CHIC1 -0.07 0.96422 -0.11 0.83368 PITA; miRanda; miRNATAP -0.22 0.01715 NA
108 hsa-miR-338-3p CHL1 0.26 0.82352 -0.21 0.62739 MirTarget; PITA; miRanda -0.25 0.02306 NA
109 hsa-miR-107 CHODL -0.07 0.96422 -0.08 0.88134 miRanda -1.1 0 NA
110 hsa-miR-338-3p CHODL 0.26 0.82352 -0.08 0.88134 miRanda -0.43 4.0E-5 NA
111 hsa-miR-338-3p CHST10 0.26 0.82352 0.19 0.53596 miRanda -0.21 0.00191 NA
112 hsa-miR-107 CIRBP -0.07 0.96422 -0.07 0.94837 mirMAP -0.17 0.00356 NA
113 hsa-miR-107 CKB -0.07 0.96422 -0.7 0.54933 miRanda -0.52 0.02288 NA
114 hsa-miR-107 CLIP1 -0.07 0.96422 -0 0.99869 MirTarget; miRanda; miRNATAP -0.13 0.00532 NA
115 hsa-miR-107 CLIP4 -0.07 0.96422 0.12 0.75478 miRanda -0.63 0.00036 NA
116 hsa-miR-107 CLU -0.07 0.96422 -0.34 0.68818 miRanda -0.88 0 NA
117 hsa-miR-107 CNIH3 -0.07 0.96422 -0.18 0.5887 miRanda; miRNATAP -0.65 9.0E-5 NA
118 hsa-miR-107 CNNM2 -0.07 0.96422 -0.13 0.79721 MirTarget; PITA; miRanda; miRNATAP -0.12 0.03281 NA
119 hsa-miR-338-3p CNR1 0.26 0.82352 -0.66 0.19872 PITA; miRanda -0.26 0.02962 NA
120 hsa-miR-338-3p CNTLN 0.26 0.82352 -0.05 0.8892 miRanda -0.23 0.00016 NA
121 hsa-miR-338-3p CNTN2 0.26 0.82352 -0.4 0.51237 mirMAP -0.28 0.00767 NA
122 hsa-miR-107 CNTN3 -0.07 0.96422 0.46 0.37052 miRanda -0.64 0.02536 NA
123 hsa-miR-107 CNTN4 -0.07 0.96422 -0.23 0.49815 miRanda -0.55 0.00274 NA
124 hsa-miR-107 CNTNAP1 -0.07 0.96422 0.03 0.94977 MirTarget; PITA; miRanda; miRNATAP -0.85 0 NA
125 hsa-miR-107 COL12A1 -0.07 0.96422 0.05 0.9648 miRanda -0.32 0.04937 NA
126 hsa-miR-107 COL1A1 -0.07 0.96422 0.38 0.81061 PITA; miRanda -0.42 0.0255 NA
127 hsa-miR-107 COL24A1 -0.07 0.96422 0.07 0.84765 miRanda -0.47 0.02668 NA
128 hsa-miR-107 COL3A1 -0.07 0.96422 0.23 0.88029 miRanda -0.44 0.01421 NA
129 hsa-miR-107 COL5A1 -0.07 0.96422 0.21 0.85755 miRanda -0.34 0.02714 NA
130 hsa-miR-107 COL9A1 -0.07 0.96422 0.08 0.88768 miRanda -0.82 0.01147 NA
131 hsa-miR-107 COLQ -0.07 0.96422 0.31 0.14108 miRanda -0.46 5.0E-5 NA
132 hsa-miR-107 CORIN -0.07 0.96422 0.18 0.64084 miRanda -0.62 0.00473 NA
133 hsa-miR-107 CORO2B -0.07 0.96422 0.03 0.92615 MirTarget; PITA; miRanda; miRNATAP -0.52 0.00459 NA
134 hsa-miR-107 CPA6 -0.07 0.96422 0.24 0.70611 miRanda -0.84 0.0223 NA
135 hsa-miR-338-3p CPLX2 0.26 0.82352 -0.44 0.40994 PITA; mirMAP -0.33 0.01349 NA
136 hsa-miR-338-3p CRMP1 0.26 0.82352 -0.12 0.7553 miRanda -0.17 0.00638 NA
137 hsa-miR-338-3p CRYM 0.26 0.82352 -0.07 0.87009 miRanda -0.19 0.02278 NA
138 hsa-miR-107 CSRP1 -0.07 0.96422 0.21 0.8493 miRanda -0.48 0 NA
139 hsa-miR-338-3p DACT3 0.26 0.82352 0.24 0.54313 miRanda -0.23 0.00186 NA
140 hsa-miR-107 DBNDD2 -0.07 0.96422 0.07 0.94458 miRanda -0.15 0.03911 NA
141 hsa-miR-107 DCLK1 -0.07 0.96422 -0.42 0.28986 miRNATAP -0.83 0.00029 NA
142 hsa-miR-338-3p DCLK2 0.26 0.82352 0.06 0.82629 miRanda -0.16 0.01167 NA
143 hsa-miR-107 DDAH2 -0.07 0.96422 0.17 0.8582 miRanda -0.27 0.0051 NA
144 hsa-miR-338-3p DDIT4L 0.26 0.82352 0.41 0.36934 miRanda -0.32 0.00233 NA
145 hsa-miR-338-3p DENND5A 0.26 0.82352 -0.02 0.97749 miRanda -0.2 0 NA
146 hsa-miR-338-3p DES 0.26 0.82352 -0.26 0.79221 PITA; miRanda -0.66 4.0E-5 NA
147 hsa-miR-338-3p DGKB 0.26 0.82352 -0.09 0.88559 MirTarget; PITA; miRanda -0.3 0.01219 NA
148 hsa-miR-107 DHRS12 -0.07 0.96422 -0 0.99413 miRanda -0.29 0.00272 NA
149 hsa-miR-107 DIP2C -0.07 0.96422 -0.09 0.87596 miRanda -0.56 0 NA
150 hsa-miR-107 DKK1 -0.07 0.96422 0.2 0.73405 miRanda -1.07 0.00153 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CARDIOVASCULAR SYSTEM DEVELOPMENT 88 788 3.979e-23 9.258e-20
2 CIRCULATORY SYSTEM DEVELOPMENT 88 788 3.979e-23 9.258e-20
3 NEUROGENESIS 117 1402 6.884e-20 1.068e-16
4 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 128 1672 1.293e-18 1.504e-15
5 CELL DEVELOPMENT 114 1426 5.949e-18 5.536e-15
6 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 61 513 1.475e-17 1.144e-14
7 HEART DEVELOPMENT 56 466 2.089e-16 1.388e-13
8 REGULATION OF CELL DIFFERENTIATION 113 1492 4.43e-16 2.576e-13
9 BIOLOGICAL ADHESION 88 1032 1.411e-15 7.297e-13
10 REGULATION OF MEMBRANE POTENTIAL 45 343 8.401e-15 3.909e-12
11 CELLULAR COMPONENT MORPHOGENESIS 79 900 9.871e-15 4.175e-12
12 VASCULATURE DEVELOPMENT 53 469 1.805e-14 6.089e-12
13 NEURON DIFFERENTIATION 77 874 1.832e-14 6.089e-12
14 REGULATION OF CELL DEVELOPMENT 75 836 1.617e-14 6.089e-12
15 BEHAVIOR 55 516 6.67e-14 2.069e-11
16 REGULATION OF BLOOD CIRCULATION 39 295 4.215e-13 1.226e-10
17 NEURON PROJECTION DEVELOPMENT 55 545 6.308e-13 1.726e-10
18 TISSUE DEVELOPMENT 106 1518 8.222e-13 2.125e-10
19 NEURON DEVELOPMENT 63 687 9.147e-13 2.24e-10
20 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 87 1142 1.26e-12 2.931e-10
21 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 66 750 1.664e-12 3.686e-10
22 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 93 1275 2.302e-12 4.869e-10
23 TISSUE MORPHOGENESIS 53 533 3.006e-12 6.082e-10
24 REGULATION OF NEURON DIFFERENTIATION 54 554 4.063e-12 7.878e-10
25 REGULATION OF HEART CONTRACTION 32 221 4.759e-12 8.857e-10
26 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 79 1021 7.11e-12 1.272e-09
27 REGULATION OF SYSTEM PROCESS 50 507 1.72e-11 2.964e-09
28 SINGLE ORGANISM BEHAVIOR 42 384 2.942e-11 4.889e-09
29 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 66 801 3.064e-11 4.916e-09
30 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 74 957 3.62e-11 5.33e-09
31 CELL CELL SIGNALING 64 767 3.665e-11 5.33e-09
32 NEURON PROJECTION MORPHOGENESIS 43 402 3.523e-11 5.33e-09
33 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 40 368 1.063e-10 1.499e-08
34 CELL PROJECTION ORGANIZATION 70 902 1.096e-10 1.5e-08
35 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 94 1395 1.38e-10 1.834e-08
36 NEGATIVE REGULATION OF CELL DIFFERENTIATION 54 609 1.489e-10 1.924e-08
37 REGULATION OF CELL PROJECTION ORGANIZATION 51 558 1.695e-10 2.132e-08
38 REGULATION OF DEVELOPMENTAL GROWTH 34 289 3.386e-10 4.053e-08
39 ACTION POTENTIAL 19 94 3.397e-10 4.053e-08
40 COGNITION 31 251 6.173e-10 7.181e-08
41 POSITIVE REGULATION OF CELL DIFFERENTIATION 64 823 6.752e-10 7.663e-08
42 MODULATION OF SYNAPTIC TRANSMISSION 34 301 9.983e-10 1.106e-07
43 MUSCLE STRUCTURE DEVELOPMENT 42 432 1.158e-09 1.253e-07
44 REGULATION OF ION TRANSPORT 51 592 1.339e-09 1.416e-07
45 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 42 437 1.638e-09 1.671e-07
46 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 29 232 1.67e-09 1.671e-07
47 POSITIVE REGULATION OF CELL DEVELOPMENT 44 472 1.722e-09 1.671e-07
48 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 27 204 1.724e-09 1.671e-07
49 REGULATION OF NEURON PROJECTION DEVELOPMENT 40 408 2.278e-09 2.149e-07
50 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 23 153 2.309e-09 2.149e-07
51 MUSCLE SYSTEM PROCESS 32 282 2.778e-09 2.535e-07
52 EMBRYO DEVELOPMENT 66 894 2.986e-09 2.672e-07
53 BLOOD VESSEL MORPHOGENESIS 37 364 3.456e-09 3.034e-07
54 LOCOMOTION 76 1114 5.804e-09 5.001e-07
55 MULTICELLULAR ORGANISMAL SIGNALING 20 123 6.425e-09 5.436e-07
56 CENTRAL NERVOUS SYSTEM DEVELOPMENT 64 872 6.61e-09 5.492e-07
57 SYNAPTIC SIGNALING 40 424 6.854e-09 5.595e-07
58 MUSCLE CONTRACTION 28 233 7.727e-09 6.199e-07
59 REGULATION OF TRANSPORT 107 1804 8.83e-09 6.963e-07
60 CELL SUBSTRATE ADHESION 23 164 9.06e-09 7.026e-07
61 ORGAN MORPHOGENESIS 62 841 9.793e-09 7.47e-07
62 EMBRYONIC MORPHOGENESIS 46 539 1.181e-08 8.862e-07
63 LOCOMOTORY BEHAVIOR 24 181 1.331e-08 9.829e-07
64 HEART MORPHOGENESIS 26 212 1.734e-08 1.261e-06
65 POSITIVE REGULATION OF NEURON DIFFERENTIATION 32 306 2.034e-08 1.456e-06
66 REGULATION OF TRANSMEMBRANE TRANSPORT 39 426 2.415e-08 1.702e-06
67 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 27 232 2.835e-08 1.969e-06
68 HEAD DEVELOPMENT 54 709 3.155e-08 2.159e-06
69 CELL PART MORPHOGENESIS 50 633 3.33e-08 2.246e-06
70 MORPHOGENESIS OF AN EPITHELIUM 37 400 4.243e-08 2.821e-06
71 SKELETAL SYSTEM DEVELOPMENT 40 455 4.862e-08 3.186e-06
72 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 31 303 5.606e-08 3.623e-06
73 TUBE DEVELOPMENT 45 552 6.635e-08 4.172e-06
74 REGULATION OF CELL MORPHOGENESIS 45 552 6.635e-08 4.172e-06
75 MUSCLE TISSUE DEVELOPMENT 29 275 7.813e-08 4.847e-06
76 DIVALENT INORGANIC CATION HOMEOSTASIS 33 343 9.143e-08 5.598e-06
77 METAL ION TRANSPORT 46 582 1.177e-07 7.11e-06
78 INORGANIC ION TRANSMEMBRANE TRANSPORT 46 583 1.237e-07 7.379e-06
79 NEURON PROJECTION GUIDANCE 24 205 1.488e-07 8.762e-06
80 NEGATIVE REGULATION OF CELL DEVELOPMENT 30 303 1.887e-07 1.098e-05
81 CELL MOTILITY 58 835 2.304e-07 1.307e-05
82 LOCALIZATION OF CELL 58 835 2.304e-07 1.307e-05
83 TUBE MORPHOGENESIS 31 323 2.368e-07 1.327e-05
84 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 65 983 2.491e-07 1.38e-05
85 ANGIOGENESIS 29 293 3.038e-07 1.663e-05
86 MUSCLE ORGAN DEVELOPMENT 28 277 3.153e-07 1.706e-05
87 CELL CELL ADHESION 46 608 4.126e-07 2.207e-05
88 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 23 203 4.859e-07 2.569e-05
89 CALCIUM ION TRANSMEMBRANE TRANSPORT 20 159 5.091e-07 2.662e-05
90 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 10 39 5.169e-07 2.672e-05
91 ION HOMEOSTASIS 44 576 5.701e-07 2.915e-05
92 MEMBRANE DEPOLARIZATION 12 61 8.453e-07 4.275e-05
93 REGULATION OF ANATOMICAL STRUCTURE SIZE 38 472 9.621e-07 4.814e-05
94 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 26 262 1.178e-06 5.829e-05
95 KIDNEY EPITHELIUM DEVELOPMENT 17 125 1.207e-06 5.911e-05
96 CYTOSKELETON ORGANIZATION 56 838 1.273e-06 6.172e-05
97 EPITHELIUM DEVELOPMENT 61 945 1.323e-06 6.347e-05
98 REGULATION OF SYNAPTIC PLASTICITY 18 140 1.361e-06 6.462e-05
99 REGULATION OF SYNAPSE ORGANIZATION 16 113 1.436e-06 6.716e-05
100 HEART VALVE DEVELOPMENT 9 34 1.443e-06 6.716e-05
101 SYSTEM PROCESS 98 1785 1.498e-06 6.903e-05
102 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 19 156 1.602e-06 7.31e-05
103 NEPHRON DEVELOPMENT 16 115 1.821e-06 8.228e-05
104 CARDIAC CHAMBER DEVELOPMENT 18 144 2.057e-06 9.205e-05
105 MUSCLE CELL DIFFERENTIATION 24 237 2.112e-06 9.36e-05
106 CHEMICAL HOMEOSTASIS 57 874 2.18e-06 9.571e-05
107 REGULATION OF NEUROTRANSMITTER LEVELS 21 190 2.268e-06 9.864e-05
108 LEARNING 17 131 2.339e-06 0.0001008
109 REGULATION OF CELLULAR COMPONENT MOVEMENT 52 771 2.366e-06 0.000101
110 REGULATION OF METAL ION TRANSPORT 29 325 2.542e-06 0.0001075
111 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 22 208 2.731e-06 0.0001145
112 CELL MATRIX ADHESION 16 119 2.883e-06 0.0001198
113 SPINAL CORD DEVELOPMENT 15 106 3.07e-06 0.0001253
114 NEPHRON EPITHELIUM DEVELOPMENT 14 93 3.097e-06 0.0001253
115 POSITIVE REGULATION OF BLOOD CIRCULATION 14 93 3.097e-06 0.0001253
116 ION TRANSMEMBRANE TRANSPORT 54 822 3.292e-06 0.0001321
117 INTEGRIN MEDIATED SIGNALING PATHWAY 13 82 3.847e-06 0.0001517
118 CARDIAC CONDUCTION 13 82 3.847e-06 0.0001517
119 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 10 48 4.031e-06 0.0001576
120 TAXIS 36 464 4.318e-06 0.0001674
121 REGULATION OF POTASSIUM ION TRANSPORT 13 83 4.422e-06 0.00017
122 UROGENITAL SYSTEM DEVELOPMENT 27 299 4.491e-06 0.0001713
123 APPENDAGE DEVELOPMENT 19 169 5.316e-06 0.0001995
124 LIMB DEVELOPMENT 19 169 5.316e-06 0.0001995
125 CATION TRANSPORT 52 796 5.888e-06 0.0002192
126 REGULATION OF ORGAN GROWTH 12 73 6.139e-06 0.0002267
127 REGULATION OF HEART RATE 13 86 6.624e-06 0.0002427
128 OVULATION CYCLE 15 113 6.876e-06 0.00025
129 RESPONSE TO GROWTH FACTOR 36 475 7.284e-06 0.0002627
130 MESENCHYME DEVELOPMENT 20 190 8.261e-06 0.0002934
131 STEM CELL DIFFERENTIATION 20 190 8.261e-06 0.0002934
132 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 20 191 8.938e-06 0.0003151
133 SYNAPSE ORGANIZATION 17 145 9.411e-06 0.0003268
134 CIRCULATORY SYSTEM PROCESS 30 366 9.395e-06 0.0003268
135 REGULATION OF NEUROTRANSMITTER TRANSPORT 11 64 9.592e-06 0.0003306
136 REGULATION OF ACTIN FILAMENT BASED PROCESS 27 312 9.844e-06 0.0003343
137 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 46 684 9.841e-06 0.0003343
138 RESPONSE TO ENDOGENOUS STIMULUS 80 1450 1.293e-05 0.0004359
139 REGULATION OF CARDIAC CONDUCTION 11 66 1.302e-05 0.000436
140 MESENCHYMAL CELL DIFFERENTIATION 16 134 1.357e-05 0.0004511
141 ACTIN FILAMENT BASED PROCESS 34 450 1.39e-05 0.0004587
142 REGULATION OF SYNAPSE ASSEMBLY 12 79 1.419e-05 0.0004633
143 CELLULAR CHEMICAL HOMEOSTASIS 40 570 1.424e-05 0.0004633
144 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 10 55 1.454e-05 0.0004689
145 POSTSYNAPTIC MEMBRANE ORGANIZATION 7 25 1.461e-05 0.0004689
146 REGULATION OF GROWTH 43 633 1.508e-05 0.0004806
147 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 18 166 1.542e-05 0.0004882
148 ADULT LOCOMOTORY BEHAVIOR 12 80 1.618e-05 0.0005088
149 HETEROPHILIC CELL CELL ADHESION VIA PLASMA MEMBRANE CELL ADHESION MOLECULES 9 45 1.744e-05 0.0005446
150 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 60 1008 1.97e-05 0.0006112
151 POTASSIUM ION TRANSPORT 17 154 2.091e-05 0.0006445
152 POSITIVE REGULATION OF GENE EXPRESSION 91 1733 2.162e-05 0.0006618
153 CARDIAC MUSCLE TISSUE DEVELOPMENT 16 140 2.361e-05 0.0007179
154 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 45 689 2.532e-05 0.000765
155 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 12 84 2.681e-05 0.0008048
156 CALCIUM ION TRANSPORT 21 223 2.73e-05 0.0008143
157 CARDIAC MUSCLE CELL ACTION POTENTIAL 8 37 2.82e-05 0.0008356
158 CARDIAC SEPTUM DEVELOPMENT 12 85 3.026e-05 0.0008897
159 REGULATION OF ORGAN MORPHOGENESIS 22 242 3.052e-05 0.0008897
160 REGULATION OF STEM CELL DIFFERENTIATION 14 113 3.059e-05 0.0008897
161 STRIATED MUSCLE CONTRACTION 13 99 3.138e-05 0.000907
162 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 8 38 3.466e-05 0.0009954
163 NEGATIVE REGULATION OF LOCOMOTION 23 263 3.745e-05 0.001069
164 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 38 554 3.823e-05 0.001078
165 CONNECTIVE TISSUE DEVELOPMENT 19 194 3.805e-05 0.001078
166 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 27 337 3.872e-05 0.001085
167 AXONAL FASCICULATION 6 20 3.959e-05 0.001103
168 REGULATION OF CELLULAR COMPONENT BIOGENESIS 48 767 4.027e-05 0.001115
169 FOREBRAIN DEVELOPMENT 28 357 4.089e-05 0.001126
170 PROTEIN PHOSPHORYLATION 56 944 4.121e-05 0.001128
171 CARTILAGE DEVELOPMENT 16 147 4.32e-05 0.001169
172 EMBRYONIC HEART TUBE MORPHOGENESIS 10 62 4.311e-05 0.001169
173 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 65 1152 4.567e-05 0.001228
174 RESPIRATORY SYSTEM DEVELOPMENT 19 197 4.698e-05 0.001256
175 REGULATION OF NEUROTRANSMITTER SECRETION 9 51 4.988e-05 0.001324
176 REGULATION OF TRANSPORTER ACTIVITY 19 198 5.035e-05 0.001324
177 DIVALENT INORGANIC CATION TRANSPORT 23 268 5.02e-05 0.001324
178 CARDIAC CHAMBER MORPHOGENESIS 13 104 5.311e-05 0.001388
179 MORPHOGENESIS OF A BRANCHING STRUCTURE 17 167 5.925e-05 0.00154
180 RENAL TUBULE DEVELOPMENT 11 78 6.514e-05 0.001674
181 CARDIAC VENTRICLE DEVELOPMENT 13 106 6.492e-05 0.001674
182 EMBRYONIC ORGAN DEVELOPMENT 30 406 6.622e-05 0.001693
183 CYTOSOLIC CALCIUM ION TRANSPORT 9 53 6.838e-05 0.001739
184 REGULATION OF HEART GROWTH 8 42 7.417e-05 0.001876
185 TRANSMISSION OF NERVE IMPULSE 9 54 7.961e-05 0.002002
186 NEGATIVE REGULATION OF POTASSIUM ION TRANSPORT 7 32 8.311e-05 0.002079
187 BONE DEVELOPMENT 16 156 8.86e-05 0.002205
188 STRIATED MUSCLE CELL DIFFERENTIATION 17 173 9.211e-05 0.002268
189 REGULATION OF CELL SUBSTRATE ADHESION 17 173 9.211e-05 0.002268
190 REGULATION OF N METHYL D ASPARTATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 5 15 0.0001026 0.002514
191 KIDNEY MORPHOGENESIS 11 82 0.0001037 0.002525
192 NEGATIVE REGULATION OF TRANSPORT 32 458 0.0001099 0.002664
193 PATTERN SPECIFICATION PROCESS 30 418 0.0001116 0.002676
194 RESPONSE TO MECHANICAL STIMULUS 19 210 0.000111 0.002676
195 NEUROMUSCULAR PROCESS 12 97 0.0001131 0.002698
196 DEVELOPMENTAL MATURATION 18 193 0.0001136 0.002698
197 POSITIVE REGULATION OF LOCOMOTION 30 420 0.0001214 0.002865
198 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 15 144 0.0001225 0.002865
199 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 6 24 0.0001223 0.002865
200 REGULATION OF GTPASE ACTIVITY 42 673 0.0001292 0.002978
201 EXTRACELLULAR STRUCTURE ORGANIZATION 24 304 0.0001287 0.002978
202 POSITIVE REGULATION OF OSSIFICATION 11 84 0.0001293 0.002978
203 CELLULAR HOMEOSTASIS 42 676 0.0001423 0.003261
204 REGULATION OF CHONDROCYTE DIFFERENTIATION 8 46 0.0001454 0.003269
205 HEART PROCESS 11 85 0.000144 0.003269
206 PROTEIN LOCALIZATION TO SYNAPSE 5 16 0.0001451 0.003269
207 ATRIOVENTRICULAR VALVE MORPHOGENESIS 5 16 0.0001451 0.003269
208 STARTLE RESPONSE 6 25 0.0001564 0.003498
209 PRESYNAPTIC PROCESS INVOLVED IN SYNAPTIC TRANSMISSION 13 116 0.0001645 0.003662
210 DIGESTIVE SYSTEM DEVELOPMENT 15 148 0.0001665 0.00369
211 EMBRYONIC HEART TUBE DEVELOPMENT 10 73 0.000178 0.003925
212 REGULATION OF RECEPTOR ACTIVITY 13 117 0.0001794 0.003937
213 REGIONALIZATION 24 311 0.0001817 0.003968
214 REGULATION OF MUSCLE TISSUE DEVELOPMENT 12 103 0.0002014 0.004333
215 ACTIN MEDIATED CELL CONTRACTION 10 74 0.0001996 0.004333
216 POSITIVE REGULATION OF GROWTH 20 238 0.0002021 0.004333
217 REGULATION OF MUSCLE ORGAN DEVELOPMENT 12 103 0.0002014 0.004333
218 RESPONSE TO EXTERNAL STIMULUS 90 1821 0.0002102 0.004465
219 REGULATION OF POTASSIUM ION TRANSMEMBRANE TRANSPORT 9 61 0.00021 0.004465
220 ADULT BEHAVIOR 14 135 0.000214 0.004506
221 TRANSMEMBRANE TRANSPORT 60 1098 0.000214 0.004506
222 MONOVALENT INORGANIC CATION TRANSPORT 30 435 0.0002235 0.004684
223 CARDIAC SEPTUM MORPHOGENESIS 8 49 0.0002297 0.004793
224 POSITIVE REGULATION OF CELL COMMUNICATION 78 1532 0.0002345 0.004872
225 POSITIVE REGULATION OF HEART GROWTH 6 27 0.0002466 0.0051
226 SKELETAL MUSCLE ORGAN DEVELOPMENT 14 137 0.0002496 0.00514
227 COLLAGEN FIBRIL ORGANIZATION 7 38 0.0002609 0.005302
228 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 7 38 0.0002609 0.005302
229 POSITIVE REGULATION OF ORGAN GROWTH 7 38 0.0002609 0.005302
230 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 8 50 0.0002654 0.005369
231 REGULATION OF CYTOSKELETON ORGANIZATION 33 502 0.0002668 0.005374
232 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 5 18 0.000269 0.005387
233 REGULATION OF CARTILAGE DEVELOPMENT 9 63 0.0002697 0.005387
234 NEUROTRANSMITTER TRANSPORT 15 155 0.0002769 0.005506
235 NEGATIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 12 107 0.0002886 0.005714
236 SIGNAL RELEASE 16 173 0.0002948 0.005812
237 NEURONAL ACTION POTENTIAL 6 28 0.0003049 0.005986
238 LONG TERM SYNAPTIC POTENTIATION 7 39 0.0003088 0.006011
239 NEGATIVE CHEMOTAXIS 7 39 0.0003088 0.006011
240 ACTIN FILAMENT BASED MOVEMENT 11 93 0.0003219 0.00624
241 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 0.0003393 0.00655
242 DENDRITE DEVELOPMENT 10 79 0.0003437 0.006608
243 ION TRANSPORT 66 1262 0.000353 0.006684
244 REGULATION OF ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLE PROPIONATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 5 19 0.0003548 0.006684
245 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 5 19 0.0003548 0.006684
246 ATRIOVENTRICULAR VALVE DEVELOPMENT 5 19 0.0003548 0.006684
247 ESTROUS CYCLE 5 19 0.0003548 0.006684
248 NEGATIVE REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 4 11 0.0003652 0.006852
249 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 70 1360 0.0003667 0.006852
250 REGULATION OF THE FORCE OF HEART CONTRACTION 6 29 0.0003734 0.006868
251 CARDIAC MUSCLE CELL CONTRACTION 6 29 0.0003734 0.006868
252 NEURON MIGRATION 12 110 0.0003733 0.006868
253 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION 12 110 0.0003733 0.006868
254 MULTI MULTICELLULAR ORGANISM PROCESS 18 213 0.0003862 0.007075
255 SECOND MESSENGER MEDIATED SIGNALING 15 160 0.00039 0.007117
256 REGULATION OF G PROTEIN COUPLED RECEPTOR PROTEIN SIGNALING PATHWAY 13 127 0.0004042 0.007347
257 REGULATION OF OSSIFICATION 16 178 0.0004059 0.00735
258 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 14 144 0.0004175 0.007486
259 GROWTH 28 410 0.0004183 0.007486
260 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 87 1784 0.0004163 0.007486
261 NEGATIVE REGULATION OF G PROTEIN COUPLED RECEPTOR PROTEIN SIGNALING PATHWAY 7 41 0.0004254 0.007556
262 RECEPTOR CLUSTERING 7 41 0.0004254 0.007556
263 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 9 67 0.0004318 0.00764
264 RESPONSE TO OXYGEN LEVELS 23 311 0.0004497 0.007926
265 MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 6 30 0.0004535 0.007932
266 REGULATION OF NEUROTRANSMITTER RECEPTOR ACTIVITY 6 30 0.0004535 0.007932
267 VENTRICULAR SEPTUM DEVELOPMENT 8 54 0.0004564 0.007953
268 VASCULAR PROCESS IN CIRCULATORY SYSTEM 15 163 0.0004754 0.008253
269 REGULATION OF NEUROLOGICAL SYSTEM PROCESS 9 68 0.0004829 0.008353
270 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 19 236 0.0004934 0.008449
271 RESPONSE TO WOUNDING 35 563 0.0004955 0.008449
272 DENDRITE MORPHOGENESIS 7 42 0.0004957 0.008449
273 DEVELOPMENTAL GROWTH 24 333 0.0004949 0.008449
274 REGULATION OF HYDROLASE ACTIVITY 68 1327 0.0005024 0.008532
275 MEMORY 11 98 0.0005075 0.008564
276 INTRACELLULAR SIGNAL TRANSDUCTION 78 1572 0.0005094 0.008564
277 RESPONSE TO ESTROGEN 18 218 0.0005098 0.008564
278 NEGATIVE REGULATION OF NITRIC OXIDE METABOLIC PROCESS 4 12 0.000533 0.008858
279 NEGATIVE REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 4 12 0.000533 0.008858
280 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 89 1848 0.0005321 0.008858
281 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 13 131 0.0005452 0.009029
282 RESPONSE TO OXYGEN CONTAINING COMPOUND 70 1381 0.0005607 0.009251
283 EPITHELIAL TO MESENCHYMAL TRANSITION 8 56 0.0005869 0.009616
284 POSITIVE REGULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 5 21 0.0005868 0.009616
285 RHYTHMIC PROCESS 22 298 0.0006072 0.009913
NumGOOverlapSizeP ValueAdj. P Value
1 CATION CHANNEL ACTIVITY 36 298 4.774e-11 4.435e-08
2 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 42 417 3.936e-10 1.828e-07
3 GATED CHANNEL ACTIVITY 33 325 2.513e-08 6.642e-06
4 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 41 464 2.86e-08 6.642e-06
5 VOLTAGE GATED ION CHANNEL ACTIVITY 23 190 1.465e-07 2.723e-05
6 CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 18 128 3.548e-07 4.709e-05
7 INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 42 527 3.379e-07 4.709e-05
8 ION CHANNEL BINDING 16 111 1.125e-06 0.0001307
9 CYTOSKELETAL PROTEIN BINDING 55 819 1.368e-06 0.0001412
10 ACTIN BINDING 33 393 2.013e-06 0.000187
11 CELL ADHESION MOLECULE BINDING 20 186 5.99e-06 0.0005059
12 CALCIUM ION BINDING 47 697 7.34e-06 0.0005179
13 GLYCOSAMINOGLYCAN BINDING 21 205 7.567e-06 0.0005179
14 POTASSIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 17 143 7.805e-06 0.0005179
15 CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 43 622 9.846e-06 0.0005897
16 CHANNEL REGULATOR ACTIVITY 16 131 1.016e-05 0.0005897
17 MOLECULAR FUNCTION REGULATOR 76 1353 1.169e-05 0.0006391
18 VOLTAGE GATED CATION CHANNEL ACTIVITY 16 134 1.357e-05 0.0007006
19 POTASSIUM CHANNEL ACTIVITY 15 120 1.442e-05 0.0007051
20 DIVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 18 167 1.675e-05 0.0007779
21 SULFUR COMPOUND BINDING 22 234 1.816e-05 0.0008032
22 HEPARIN BINDING 17 157 2.689e-05 0.001136
23 CALMODULIN BINDING 18 179 4.267e-05 0.001652
24 RECEPTOR BINDING 79 1476 4.204e-05 0.001652
25 POTASSIUM CHANNEL REGULATOR ACTIVITY 8 46 0.0001454 0.005404
26 SH3 DOMAIN BINDING 13 116 0.0001645 0.00566
27 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 25 328 0.000163 0.00566
28 PROTEIN COMPLEX BINDING 53 935 0.0002083 0.006912
29 VOLTAGE GATED POTASSIUM CHANNEL ACTIVITY 11 89 0.000218 0.006984
30 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 10 76 0.0002495 0.007297
31 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 64 1199 0.0002513 0.007297
32 CHEMOREPELLENT ACTIVITY 6 27 0.0002466 0.007297
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 92 942 4.256e-20 2.485e-17
2 NEURON PART 105 1265 1.113e-17 3.25e-15
3 CELL PROJECTION 129 1786 1.045e-16 2.034e-14
4 SYNAPSE 73 754 7.188e-16 1.049e-13
5 AXON 48 418 1.785e-13 2.084e-11
6 CATION CHANNEL COMPLEX 29 167 4.583e-13 4.46e-11
7 SYNAPSE PART 59 610 5.412e-13 4.515e-11
8 CELL PROJECTION PART 76 946 2.988e-12 2.181e-10
9 SOMATODENDRITIC COMPARTMENT 57 650 6.892e-11 4.472e-09
10 TRANSPORTER COMPLEX 37 321 1.01e-10 5.896e-09
11 AXON PART 29 219 4.25e-10 2.257e-08
12 CELL JUNCTION 79 1151 2.141e-09 9.619e-08
13 PLASMA MEMBRANE PROTEIN COMPLEX 46 510 2.096e-09 9.619e-08
14 POTASSIUM CHANNEL COMPLEX 17 90 8.568e-09 3.574e-07
15 POSTSYNAPSE 35 378 9.627e-08 3.748e-06
16 DENDRITE 39 451 1.107e-07 4.04e-06
17 PRESYNAPSE 29 283 1.452e-07 4.987e-06
18 EXTRACELLULAR MATRIX 37 426 2.106e-07 6.706e-06
19 PROTEINACEOUS EXTRACELLULAR MATRIX 33 356 2.182e-07 6.706e-06
20 INTRINSIC COMPONENT OF PLASMA MEMBRANE 92 1649 1.684e-06 4.916e-05
21 SARCOLEMMA 16 125 5.526e-06 0.0001537
22 PLASMA MEMBRANE REGION 58 929 6.752e-06 0.0001714
23 PLASMA MEMBRANE RAFT 13 86 6.624e-06 0.0001714
24 NEURON PROJECTION TERMINUS 16 129 8.328e-06 0.0001936
25 CELL CELL JUNCTION 31 383 8.619e-06 0.0001936
26 MEMBRANE REGION 67 1134 8.061e-06 0.0001936
27 NEURONAL POSTSYNAPTIC DENSITY 10 53 1.03e-05 0.0002229
28 CONTRACTILE FIBER 21 211 1.182e-05 0.0002465
29 SITE OF POLARIZED GROWTH 17 149 1.354e-05 0.0002726
30 EXCITATORY SYNAPSE 20 197 1.416e-05 0.0002742
31 MEMBRANE PROTEIN COMPLEX 61 1020 1.456e-05 0.0002742
32 CELL BODY 36 494 1.713e-05 0.0003126
33 EXOCYTIC VESICLE 16 142 2.818e-05 0.0004986
34 CYTOPLASMIC REGION 24 287 5.251e-05 0.000902
35 TERMINAL BOUTON 10 64 5.713e-05 0.0009533
36 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 7.04e-05 0.001118
37 CELL CORTEX 21 238 7.084e-05 0.001118
38 CELL CELL ADHERENS JUNCTION 9 54 7.961e-05 0.001223
39 T TUBULE 8 45 0.0001238 0.001854
40 MAIN AXON 9 58 0.0001412 0.002062
41 SODIUM CHANNEL COMPLEX 5 17 0.0001998 0.002846
42 I BAND 13 121 0.0002512 0.003492
43 EXTRACELLULAR MATRIX COMPONENT 13 125 0.0003462 0.004702
44 ANCHORING JUNCTION 32 489 0.0003558 0.004723
45 AXONAL GROWTH CONE 5 20 0.0004599 0.005969
46 SECRETORY VESICLE 30 461 0.000589 0.007478
47 SYNAPTIC MEMBRANE 20 261 0.0006657 0.008271
48 CELL CORTEX PART 12 119 0.0007632 0.009286
49 CYTOPLASMIC VESICLE PART 36 601 0.0008136 0.009564
50 COLLAGEN TRIMER 10 88 0.0008188 0.009564

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 18 163 1.199e-05 0.0004042
2 Calcium_signaling_pathway_hsa04020 19 182 1.555e-05 0.0004042
3 Cell_adhesion_molecules_.CAMs._hsa04514 16 145 3.65e-05 0.0006327
4 ECM_receptor_interaction_hsa04512 11 82 0.0001037 0.001348
5 Focal_adhesion_hsa04510 18 199 0.0001674 0.001741
6 cAMP_signaling_pathway_hsa04024 17 198 0.0004626 0.00401
7 Apelin_signaling_pathway_hsa04371 13 137 0.0008335 0.006192
8 Rap1_signaling_pathway_hsa04015 15 206 0.004826 0.03045
9 Regulation_of_actin_cytoskeleton_hsa04810 15 208 0.005271 0.03045
10 PI3K_Akt_signaling_pathway_hsa04151 21 352 0.009708 0.05048
11 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.01617 0.07644
12 Hedgehog_signaling_pathway_hsa04340 5 47 0.02141 0.09278
13 MAPK_signaling_pathway_hsa04010 17 295 0.02515 0.1006
14 Adherens_junction_hsa04520 6 72 0.03601 0.1338
15 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 9 139 0.04871 0.1689
16 TGF_beta_signaling_pathway_hsa04350 6 84 0.06706 0.2179
17 Autophagy_animal_hsa04140 8 128 0.07175 0.2195
18 Hippo_signaling_pathway_hsa04390 9 154 0.08137 0.2256
19 FoxO_signaling_pathway_hsa04068 8 132 0.08243 0.2256
20 Ras_signaling_pathway_hsa04014 12 232 0.1006 0.2616
21 Phospholipase_D_signaling_pathway_hsa04072 8 146 0.1267 0.3138
22 Mitophagy_animal_hsa04137 4 65 0.1809 0.4276
23 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.249 0.5572
24 mTOR_signaling_pathway_hsa04150 7 151 0.2572 0.5572
25 VEGF_signaling_pathway_hsa04370 3 59 0.3266 0.6793
26 Neuroactive_ligand_receptor_interaction_hsa04080 11 278 0.3506 0.6797
27 Gap_junction_hsa04540 4 88 0.3529 0.6797
28 Sphingolipid_signaling_pathway_hsa04071 5 118 0.3759 0.6898
29 AMPK_signaling_pathway_hsa04152 5 121 0.3962 0.6898
30 Ferroptosis_hsa04216 2 40 0.398 0.6898
31 Cellular_senescence_hsa04218 6 160 0.4652 0.7803
32 Tight_junction_hsa04530 6 170 0.524 0.8408
33 ErbB_signaling_pathway_hsa04012 3 85 0.5577 0.8408
34 Wnt_signaling_pathway_hsa04310 5 146 0.5594 0.8408
35 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 0.575 0.8408
36 Endocytosis_hsa04144 8 244 0.5949 0.8408
37 Lysosome_hsa04142 4 123 0.6081 0.8408
38 Cell_cycle_hsa04110 4 124 0.6144 0.8408
39 HIF_1_signaling_pathway_hsa04066 3 100 0.6676 0.8721
40 Phagosome_hsa04145 4 152 0.7658 0.9588
41 Oocyte_meiosis_hsa04114 3 124 0.7994 0.9588
42 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.8394 0.9652
43 Apoptosis_hsa04210 3 138 0.8539 0.9652
44 TNF_signaling_pathway_hsa04668 2 108 0.8871 0.9814
45 Jak_STAT_signaling_pathway_hsa04630 2 162 0.976 1

Quest ID: f379bfdbedfb582b3178c7239f0b8c3f