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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-101-3p PRR11 0.52 0.00376 2.86 0 MirTarget -0.62 0 NA
2 hsa-miR-139-5p PRR11 -1.53 0 2.86 0 miRanda -0.35 7.0E-5 NA
3 hsa-miR-199b-5p PRR11 0.22 0.51949 2.86 0 miRanda -0.15 0.02952 NA
4 hsa-miR-320a PRR11 0.44 0.03902 2.86 0 miRanda -0.48 2.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 6 104 8.703e-10 3.734e-06
2 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 6 123 2.408e-09 3.734e-06
3 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 6 118 1.873e-09 3.734e-06
4 MULTI ORGANISM METABOLIC PROCESS 6 138 4.821e-09 5.608e-06
5 TRANSLATIONAL INITIATION 6 146 6.767e-09 6.297e-06
6 PROTEIN TARGETING TO MEMBRANE 6 157 1.047e-08 8.117e-06
7 RIBOSOME BIOGENESIS 7 308 1.855e-08 1.233e-05
8 RNA CATABOLIC PROCESS 6 227 9.417e-08 5.477e-05
9 RRNA METABOLIC PROCESS 6 255 1.872e-07 9.679e-05
10 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 6 264 2.297e-07 9.714e-05
11 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 7 440 2.118e-07 9.714e-05
12 RIBOSOME ASSEMBLY 4 54 2.745e-07 0.0001064
13 VIRAL LIFE CYCLE 6 290 3.988e-07 0.0001427
14 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 6 361 1.432e-06 0.0004758
15 PROTEIN LOCALIZATION TO MEMBRANE 6 376 1.813e-06 0.0005273
16 RIBOSOMAL LARGE SUBUNIT ASSEMBLY 3 23 1.743e-06 0.0005273
17 NCRNA PROCESSING 6 386 2.111e-06 0.0005778
18 PROTEIN TARGETING 6 406 2.827e-06 0.0007307
19 INTERSPECIES INTERACTION BETWEEN ORGANISMS 7 662 3.27e-06 0.0007609
20 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 7 662 3.27e-06 0.0007609
21 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 6 427 3.78e-06 0.0008376
22 AMIDE BIOSYNTHETIC PROCESS 6 507 1.011e-05 0.002138
23 NCRNA METABOLIC PROCESS 6 533 1.344e-05 0.002719
24 PROTEIN LOCALIZATION TO ORGANELLE 6 556 1.708e-05 0.003311
25 RIBOSOMAL LARGE SUBUNIT BIOGENESIS 3 49 1.782e-05 0.003316
26 PEPTIDE METABOLIC PROCESS 6 571 1.985e-05 0.003553
27 MRNA METABOLIC PROCESS 6 611 2.908e-05 0.005012
28 RIBONUCLEOPROTEIN COMPLEX SUBUNIT ORGANIZATION 4 199 4.985e-05 0.008283
NumGOOverlapSizeP ValueAdj. P Value
1 POLY A RNA BINDING 11 1170 5.371e-09 4.99e-06
2 STRUCTURAL CONSTITUENT OF RIBOSOME 6 212 6.28e-08 2.917e-05
3 RNA BINDING 11 1598 1.362e-07 4.219e-05
4 RRNA BINDING 3 58 2.966e-05 0.006889
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOSOLIC RIBOSOME 7 113 1.659e-11 9.686e-09
2 RIBOSOME 7 226 2.179e-09 4.242e-07
3 CYTOSOLIC PART 7 223 1.986e-09 4.242e-07
4 NUCLEOLUS 10 848 4.108e-09 5.997e-07
5 RIBOSOMAL SUBUNIT 6 163 1.31e-08 1.531e-06
6 RIBONUCLEOPROTEIN COMPLEX 8 721 3.681e-07 3.583e-05
7 CYTOSOLIC LARGE RIBOSOMAL SUBUNIT 4 61 4.508e-07 3.761e-05
8 LARGE RIBOSOMAL SUBUNIT 4 95 2.687e-06 0.0001962
9 CELL SUBSTRATE JUNCTION 5 398 4.761e-05 0.003089
10 ANCHORING JUNCTION 5 489 0.000126 0.007356

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Tight_junction_hsa04530 2 170 0.01357 0.7054

Quest ID: f4a021ffc17f7bff4a8e7f36fb03fc54