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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200c-3p ABL2 3.5 0 -0.32 0.04554 MirTarget -0.15 0 NA
2 hsa-miR-200c-3p ACTC1 3.5 0 -7.19 0 MirTarget -1.34 0 NA
3 hsa-miR-200c-3p ADAMTS3 3.5 0 -1.18 0.00448 miRNATAP -0.41 0 NA
4 hsa-miR-200c-3p ADCY2 3.5 0 -3.87 0 MirTarget; miRNATAP -0.44 0 NA
5 hsa-miR-200c-5p AFF2 2.96 0 -1.73 0.00201 mirMAP -0.3 0 NA
6 hsa-miR-200c-3p AFF3 3.5 0 -5 0 MirTarget; miRNATAP -0.59 0 NA
7 hsa-miR-200c-3p AMOTL2 3.5 0 -1.01 0.00015 MirTarget; miRNATAP -0.22 0 NA
8 hsa-miR-200c-3p ANKH 3.5 0 -0.38 0.21654 miRNATAP -0.29 0 NA
9 hsa-miR-200c-3p AP1S2 3.5 0 -1.31 0 MirTarget; miRNATAP -0.38 0 NA
10 hsa-miR-200c-3p ARHGAP20 3.5 0 -3.52 0 MirTarget; miRNATAP -0.51 0 NA
11 hsa-miR-200c-3p ARHGAP28 3.5 0 -1.54 0.00053 MirTarget -0.2 1.0E-5 NA
12 hsa-miR-200c-3p ARHGAP6 3.5 0 -3.25 0 MirTarget -0.12 0.0192 NA
13 hsa-miR-200c-3p ARHGEF17 3.5 0 -1.19 0 miRNATAP -0.24 0 NA
14 hsa-miR-200c-3p ARL10 3.5 0 -1.12 0.00198 mirMAP -0.29 0 NA
15 hsa-miR-200c-3p ASAP1 3.5 0 0.06 0.77944 MirTarget; miRNATAP -0.16 0 NA
16 hsa-miR-200c-5p ATP1A2 2.96 0 -6.96 0 MirTarget -0.88 0 NA
17 hsa-miR-200c-3p ATXN1 3.5 0 -1.51 0 MirTarget; miRNATAP -0.24 0 NA
18 hsa-miR-200c-3p BACH2 3.5 0 -1.52 0.00134 mirMAP -0.54 0 NA
19 hsa-miR-200c-3p BASP1 3.5 0 -0.12 0.79725 miRNATAP -0.19 6.0E-5 NA
20 hsa-miR-200c-3p BCL2 3.5 0 -2.02 0 miRNAWalker2 validate; miRTarBase; mirMAP -0.19 0 NA
21 hsa-miR-200c-3p BEND4 3.5 0 -1.97 7.0E-5 mirMAP -0.32 0 NA
22 hsa-miR-200c-3p BNC2 3.5 0 -2.95 0 MirTarget -0.7 0 NA
23 hsa-miR-200c-3p C11orf87 3.5 0 -1.55 0.01186 miRNATAP -0.34 0 NA
24 hsa-miR-200c-3p C17orf51 3.5 0 -0.68 0.02254 mirMAP -0.28 0 NA
25 hsa-miR-200c-3p CACNA1C 3.5 0 -2.53 0 MirTarget -0.44 0 NA
26 hsa-miR-200c-5p CACNB2 2.96 0 -2.97 0 MirTarget; miRNATAP -0.35 0 NA
27 hsa-miR-200c-3p CALU 3.5 0 -0.15 0.46318 MirTarget -0.23 0 NA
28 hsa-miR-200c-5p CASQ2 2.96 0 -6.22 0 MirTarget -1.11 0 NA
29 hsa-miR-200c-3p CBL 3.5 0 -0.31 0.06484 MirTarget; mirMAP -0.11 0 NA
30 hsa-miR-200c-5p CCDC141 2.96 0 -2.94 0 MirTarget -0.44 0 NA
31 hsa-miR-200c-3p CDK6 3.5 0 -0.77 0.06479 mirMAP -0.32 0 NA
32 hsa-miR-200c-3p CELF2 3.5 0 -3.05 0 mirMAP; miRNATAP -0.51 0 NA
33 hsa-miR-200c-5p CELF2 2.96 0 -3.05 0 miRNATAP -0.53 0 NA
34 hsa-miR-200c-3p CFL2 3.5 0 -2.62 0 MirTarget; miRNATAP -0.48 0 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c
35 hsa-miR-200c-3p CHRDL1 3.5 0 -6.15 0 MirTarget -0.99 0 NA
36 hsa-miR-200c-3p CHST11 3.5 0 0.54 0.2311 mirMAP -0.4 0 NA
37 hsa-miR-200c-3p CIITA 3.5 0 -0.02 0.95968 mirMAP -0.2 2.0E-5 NA
38 hsa-miR-200c-3p CLIC4 3.5 0 -1.72 0 MirTarget; miRNATAP -0.46 0 NA
39 hsa-miR-200c-3p CLIP2 3.5 0 -0.8 0.00158 MirTarget; miRNATAP -0.18 0 NA
40 hsa-miR-200c-3p CNN3 3.5 0 -0.66 0.00535 MirTarget; miRNATAP -0.2 0 NA
41 hsa-miR-200c-3p CNTFR 3.5 0 -3.86 0 miRNATAP -0.44 0 NA
42 hsa-miR-200c-3p CNTN1 3.5 0 -4.98 0 MirTarget; miRNATAP -0.74 0 NA
43 hsa-miR-200c-3p CNTN4 3.5 0 -3.06 0 miRNATAP -0.19 5.0E-5 NA
44 hsa-miR-200c-5p COL11A1 2.96 0 4.69 0 MirTarget; miRNATAP -0.57 0 NA
45 hsa-miR-200c-3p COL4A3 3.5 0 -3.14 0 miRNATAP -0.32 0 NA
46 hsa-miR-200c-3p COPS8 3.5 0 -0.27 0.01391 MirTarget -0.11 0 NA
47 hsa-miR-200c-3p CORO1C 3.5 0 -1.12 0 MirTarget; miRNATAP -0.29 0 NA
48 hsa-miR-200c-5p CPEB2 2.96 0 -1.81 0 miRNATAP -0.11 7.0E-5 NA
49 hsa-miR-200c-3p CREB5 3.5 0 -2.28 0 miRNATAP -0.47 0 NA
50 hsa-miR-200c-3p CYP1B1 3.5 0 -2.82 0 miRNATAP -0.55 0 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response
51 hsa-miR-200c-3p CYTH3 3.5 0 -0.27 0.19343 MirTarget -0.17 0 NA
52 hsa-miR-200c-3p DACT1 3.5 0 -1.78 2.0E-5 miRNATAP -0.47 0 NA
53 hsa-miR-200c-3p DCBLD2 3.5 0 -0.13 0.73597 MirTarget -0.31 0 NA
54 hsa-miR-200c-3p DDIT4L 3.5 0 -1.9 0.00047 MirTarget -0.47 0 NA
55 hsa-miR-200c-3p DENND5A 3.5 0 -1.19 0 MirTarget -0.25 0 NA
56 hsa-miR-200c-3p DENND5B 3.5 0 -1.35 0.0001 MirTarget; miRNATAP -0.39 0 NA
57 hsa-miR-200c-3p DIAPH2 3.5 0 -0.89 0.00037 mirMAP -0.11 4.0E-5 NA
58 hsa-miR-200c-5p DIP2C 2.96 0 -1.11 0 mirMAP -0.12 0 NA
59 hsa-miR-200c-3p DIXDC1 3.5 0 -3.01 0 MirTarget -0.52 0 NA
60 hsa-miR-200c-3p DLC1 3.5 0 -1.8 0 miRNATAP -0.2 0 NA
61 hsa-miR-200c-3p DMD 3.5 0 -3.69 0 miRNATAP -0.53 0 NA
62 hsa-miR-200c-3p DNAJB5 3.5 0 -2.65 0 miRNATAP -0.52 0 NA
63 hsa-miR-200c-3p DOCK4 3.5 0 -0.48 0.07912 MirTarget -0.22 0 NA
64 hsa-miR-200c-3p DRP2 3.5 0 -1.35 0.00023 mirMAP -0.31 0 NA
65 hsa-miR-200c-3p DST 3.5 0 -1.12 9.0E-5 mirMAP -0.1 0.00054 NA
66 hsa-miR-200c-3p DTNA 3.5 0 -4.06 0 MirTarget -0.65 0 NA
67 hsa-miR-200c-5p DTNA 2.96 0 -4.06 0 MirTarget; miRNATAP -0.66 0 NA
68 hsa-miR-200c-3p DUSP1 3.5 0 -3.47 0 MirTarget; miRNATAP -0.32 0 NA
69 hsa-miR-200c-3p DYNC1I1 3.5 0 -2.05 0.0001 MirTarget -0.2 0.00038 NA
70 hsa-miR-200c-3p DZIP1 3.5 0 -1.57 2.0E-5 MirTarget -0.34 0 NA
71 hsa-miR-200c-3p EDNRA 3.5 0 -2.19 0 miRNAWalker2 validate; miRNATAP -0.43 0 NA
72 hsa-miR-200c-3p ELL2 3.5 0 -1.08 1.0E-5 MirTarget -0.13 0 NA
73 hsa-miR-200c-5p EML1 2.96 0 -2.07 0 MirTarget -0.33 0 NA
74 hsa-miR-200c-3p ENTPD1 3.5 0 -1.12 0 MirTarget; mirMAP -0.24 0 NA
75 hsa-miR-200c-3p ERC1 3.5 0 -1.1 0 mirMAP -0.17 0 NA
76 hsa-miR-200c-5p ESAM 2.96 0 -0.6 0.00929 MirTarget -0.15 0 NA
77 hsa-miR-200c-3p ETS1 3.5 0 -0.7 0.00228 MirTarget; miRNATAP -0.13 0 NA
78 hsa-miR-200c-3p ETV5 3.5 0 0.24 0.42305 MirTarget; miRNATAP -0.2 0 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration
79 hsa-miR-200c-3p EXT1 3.5 0 0.13 0.57371 mirMAP -0.12 0 NA
80 hsa-miR-200c-3p F2RL2 3.5 0 -0.07 0.88286 MirTarget -0.4 0 NA
81 hsa-miR-200c-5p FAM110B 2.96 0 -2.49 0 MirTarget -0.52 0 NA
82 hsa-miR-200c-3p FAT3 3.5 0 -2.79 0 MirTarget; miRNATAP -0.23 0.00025 NA
83 hsa-miR-200c-3p FBLN5 3.5 0 -2.76 0 miRNAWalker2 validate; miRTarBase -0.4 0 NA
84 hsa-miR-200c-3p FGD1 3.5 0 -0.05 0.85964 miRNATAP -0.18 0 NA
85 hsa-miR-200c-3p FGF18 3.5 0 -1.42 0.00104 miRNATAP -0.26 0 NA
86 hsa-miR-200c-3p FGF2 3.5 0 -3.46 0 mirMAP -0.58 0 NA
87 hsa-miR-200c-3p FHL1 3.5 0 -4.79 0 MirTarget -0.78 0 NA
88 hsa-miR-200c-3p FHOD1 3.5 0 0.61 0.00071 miRNAWalker2 validate -0.11 0 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins
89 hsa-miR-200c-3p FKBP14 3.5 0 0.03 0.86788 mirMAP -0.12 0 NA
90 hsa-miR-200c-3p FLI1 3.5 0 -1.11 7.0E-5 MirTarget; miRNATAP -0.32 0 NA
91 hsa-miR-200c-3p FLNA 3.5 0 -2.63 0 miRNAWalker2 validate -0.57 0 NA
92 hsa-miR-200c-3p FN1 3.5 0 -0.41 0.45793 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.66 0 NA
93 hsa-miR-200c-3p FOXF1 3.5 0 -3.6 0 MirTarget -0.33 0 NA
94 hsa-miR-200c-3p FSTL1 3.5 0 -1.2 3.0E-5 MirTarget -0.36 0 NA
95 hsa-miR-200c-3p FUNDC2 3.5 0 -0.54 1.0E-5 mirMAP -0.12 0 NA
96 hsa-miR-200c-3p FYN 3.5 0 -1.47 0 miRNATAP -0.35 0 NA
97 hsa-miR-200c-3p FZD4 3.5 0 -0.83 0.00068 mirMAP -0.11 1.0E-5 NA
98 hsa-miR-200c-3p GATA4 3.5 0 0.21 0.73605 MirTarget; miRNATAP -0.25 0.00011 NA
99 hsa-miR-200c-3p GEM 3.5 0 -3.69 0 MirTarget; miRNATAP -0.6 0 NA
100 hsa-miR-200c-3p GFI1 3.5 0 0.35 0.37482 miRNATAP -0.14 0.00083 NA
101 hsa-miR-200c-5p GFOD1 2.96 0 -0.94 0.00661 mirMAP -0.24 0 NA
102 hsa-miR-200c-3p GFRA1 3.5 0 -5 0 mirMAP -0.33 0 NA
103 hsa-miR-200c-3p GJA3 3.5 0 0.72 0.20501 mirMAP -0.16 0.00815 NA
104 hsa-miR-200c-3p GJC1 3.5 0 -0.97 0.00222 MirTarget; miRNATAP -0.31 0 NA
105 hsa-miR-200c-3p GLI3 3.5 0 -0.85 0.02024 miRNATAP -0.22 0 NA
106 hsa-miR-200c-3p GLIS2 3.5 0 -0.61 0.05279 miRNATAP -0.31 0 NA
107 hsa-miR-200c-3p GLRX 3.5 0 -0.28 0.31677 MirTarget -0.17 0 NA
108 hsa-miR-200c-5p GNAO1 2.96 0 -3.6 0 MirTarget -0.62 0 NA
109 hsa-miR-200c-3p GNG4 3.5 0 0.22 0.74468 mirMAP -0.42 0 NA
110 hsa-miR-200c-3p GPM6A 3.5 0 -4.43 0 miRNATAP -0.61 0 NA
111 hsa-miR-200c-3p GPR146 3.5 0 -1.49 0 miRNATAP -0.18 0 NA
112 hsa-miR-200c-3p GPRASP2 3.5 0 -1.46 0 MirTarget -0.18 0 NA
113 hsa-miR-200c-3p GREM1 3.5 0 0.09 0.91453 MirTarget -0.65 0 NA
114 hsa-miR-200c-3p HCFC2 3.5 0 -0.81 0 miRNATAP -0.12 0 NA
115 hsa-miR-200c-3p HDAC4 3.5 0 -1.8 0 miRNATAP -0.26 0 NA
116 hsa-miR-200c-3p HIPK3 3.5 0 -1.75 0 MirTarget -0.18 0 NA
117 hsa-miR-200c-3p HIVEP3 3.5 0 0.03 0.92033 miRNATAP -0.21 0 NA
118 hsa-miR-200c-3p HLF 3.5 0 -5.48 0 MirTarget; miRNATAP -0.6 0 NA
119 hsa-miR-200c-3p HPS5 3.5 0 -0.39 0.01461 MirTarget -0.12 0 NA
120 hsa-miR-200c-3p HS3ST3A1 3.5 0 -0.13 0.83157 MirTarget -0.63 0 NA
121 hsa-miR-200c-3p HUNK 3.5 0 -2.27 1.0E-5 mirMAP -0.23 2.0E-5 NA
122 hsa-miR-200c-3p IFIT5 3.5 0 -0.14 0.54951 miRNATAP -0.13 0 NA
123 hsa-miR-200c-3p IGSF10 3.5 0 -5.3 0 MirTarget -0.54 0 NA
124 hsa-miR-200c-3p IL6ST 3.5 0 -2.1 2.0E-5 mirMAP -0.35 0 NA
125 hsa-miR-200c-3p ITGA1 3.5 0 -1.43 0 MirTarget -0.34 0 NA
126 hsa-miR-200c-3p ITPR1 3.5 0 -2.58 0 miRNATAP -0.31 0 NA
127 hsa-miR-200c-3p ITPR2 3.5 0 -0.18 0.43611 MirTarget -0.15 0 NA
128 hsa-miR-200c-3p JAZF1 3.5 0 -1.92 0 MirTarget; miRNATAP -0.42 0 NA
129 hsa-miR-200c-3p JUN 3.5 0 -2.05 0 MirTarget -0.2 0 NA
130 hsa-miR-200c-3p KCNJ2 3.5 0 -0.28 0.36165 miRNATAP -0.12 0.00012 NA
131 hsa-miR-200c-3p KCNK2 3.5 0 -3.96 0 miRNATAP -0.5 0 NA
132 hsa-miR-200c-3p KCNQ4 3.5 0 -2.64 0 miRNATAP -0.36 0 NA
133 hsa-miR-200c-3p KCTD15 3.5 0 -1.07 0.00367 MirTarget; miRNATAP -0.22 0 NA
134 hsa-miR-200c-3p KDR 3.5 0 -0.81 0.0014 miRNATAP -0.1 0.00017 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c
135 hsa-miR-200c-3p KIAA1462 3.5 0 -1.72 0 MirTarget -0.39 0 NA
136 hsa-miR-200c-3p KIF13A 3.5 0 -1.22 0 miRNATAP -0.12 0 NA
137 hsa-miR-200c-3p KLF10 3.5 0 -1.13 0 miRNATAP -0.18 0 NA
138 hsa-miR-200c-3p KLF11 3.5 0 -0.89 1.0E-5 miRNAWalker2 validate -0.11 0 NA
139 hsa-miR-200c-3p KLF13 3.5 0 -1.16 1.0E-5 miRNATAP -0.22 0 NA
140 hsa-miR-200c-3p KLF4 3.5 0 -2.67 0 MirTarget; miRNATAP -0.11 0.00217 NA
141 hsa-miR-200c-3p KLF9 3.5 0 -2.79 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.4 0 NA
142 hsa-miR-200c-3p KLHDC1 3.5 0 -1.74 0 MirTarget -0.12 4.0E-5 NA
143 hsa-miR-200c-3p LAMC1 3.5 0 -0.82 0.0001 MirTarget; miRNATAP -0.19 0 NA
144 hsa-miR-200c-3p LATS2 3.5 0 -1.5 0 miRNATAP -0.26 0 NA
145 hsa-miR-200c-3p LHFP 3.5 0 -1.83 0 MirTarget; miRNATAP -0.36 0 NA
146 hsa-miR-200c-5p LINGO2 2.96 0 -1.99 0.00051 MirTarget -0.32 0 NA
147 hsa-miR-200c-3p LIX1L 3.5 0 -1.29 0 MirTarget -0.34 0 NA
148 hsa-miR-200c-3p LPAR1 3.5 0 -1.92 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.18 0 NA
149 hsa-miR-200c-3p LPIN1 3.5 0 -0.9 0.00013 MirTarget -0.17 0 NA
150 hsa-miR-200c-3p MAF 3.5 0 -1.28 0.00016 miRNATAP -0.36 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 87 1672 8.019e-23 3.731e-19
2 CELL DEVELOPMENT 76 1426 2.069e-20 4.813e-17
3 REGULATION OF CELL DIFFERENTIATION 75 1492 1.124e-18 1.744e-15
4 REGULATION OF CELL DEVELOPMENT 51 836 4.658e-16 5.419e-13
5 REGULATION OF NEURON DIFFERENTIATION 41 554 7.209e-16 6.709e-13
6 NEUROGENESIS 66 1402 5.179e-15 3.9e-12
7 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 55 1021 5.867e-15 3.9e-12
8 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 46 750 1.244e-14 7.236e-12
9 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 57 1142 4.592e-14 2.374e-11
10 CENTRAL NERVOUS SYSTEM DEVELOPMENT 48 872 1.789e-13 8.325e-11
11 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 35 513 1.173e-12 4.962e-10
12 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 58 1275 1.32e-12 5.024e-10
13 POSITIVE REGULATION OF CELL DIFFERENTIATION 45 823 1.404e-12 5.024e-10
14 CELLULAR COMPONENT MORPHOGENESIS 47 900 2.153e-12 6.681e-10
15 TISSUE DEVELOPMENT 64 1518 2.154e-12 6.681e-10
16 REGULATION OF CELLULAR COMPONENT MOVEMENT 43 771 2.431e-12 7.07e-10
17 REGULATION OF NEURON PROJECTION DEVELOPMENT 30 408 8.194e-12 2.243e-09
18 POSITIVE REGULATION OF NEURON DIFFERENTIATION 26 306 8.698e-12 2.248e-09
19 NEGATIVE REGULATION OF CELL PROLIFERATION 38 643 9.354e-12 2.291e-09
20 CARDIOVASCULAR SYSTEM DEVELOPMENT 42 788 1.911e-11 4.234e-09
21 CIRCULATORY SYSTEM DEVELOPMENT 42 788 1.911e-11 4.234e-09
22 HEAD DEVELOPMENT 39 709 4.226e-11 8.938e-09
23 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 30 437 4.512e-11 9.128e-09
24 POSITIVE REGULATION OF CELL DEVELOPMENT 31 472 6.433e-11 1.247e-08
25 RESPONSE TO WOUNDING 34 563 7.047e-11 1.312e-08
26 LOCOMOTION 50 1114 9.512e-11 1.702e-08
27 NEURON PROJECTION DEVELOPMENT 33 545 1.276e-10 2.199e-08
28 HEART DEVELOPMENT 30 466 2.155e-10 3.582e-08
29 REGULATION OF CELL PROJECTION ORGANIZATION 33 558 2.348e-10 3.768e-08
30 FOREBRAIN DEVELOPMENT 26 357 2.638e-10 4.091e-08
31 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 26 368 5.075e-10 7.617e-08
32 NEURON PROJECTION MORPHOGENESIS 27 402 7.129e-10 1.037e-07
33 NEURON DEVELOPMENT 36 687 9.381e-10 1.323e-07
34 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 55 1395 1.193e-09 1.632e-07
35 RESPONSE TO ENDOGENOUS STIMULUS 56 1450 1.74e-09 2.314e-07
36 REGULATION OF CELL PROLIFERATION 57 1496 1.992e-09 2.574e-07
37 POSITIVE REGULATION OF MOLECULAR FUNCTION 64 1791 2.183e-09 2.745e-07
38 BIOLOGICAL ADHESION 45 1032 2.293e-09 2.807e-07
39 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 65 1848 2.988e-09 3.476e-07
40 REGULATION OF CELL MORPHOGENESIS 31 552 2.935e-09 3.476e-07
41 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 36 724 3.775e-09 4.284e-07
42 POSITIVE REGULATION OF GENE EXPRESSION 62 1733 3.942e-09 4.367e-07
43 INTRACELLULAR SIGNAL TRANSDUCTION 58 1572 4.574e-09 4.949e-07
44 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 38 801 4.871e-09 4.996e-07
45 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 43 983 4.939e-09 4.996e-07
46 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 63 1784 4.749e-09 4.996e-07
47 NEURON DIFFERENTIATION 40 874 5.111e-09 5.06e-07
48 BEHAVIOR 29 516 9.591e-09 9.298e-07
49 MUSCLE SYSTEM PROCESS 21 282 9.84e-09 9.344e-07
50 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 43 1008 1.033e-08 9.609e-07
51 CELL PROJECTION ORGANIZATION 40 902 1.231e-08 1.123e-06
52 MESENCHYME DEVELOPMENT 17 190 1.765e-08 1.58e-06
53 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 35 740 2.23e-08 1.957e-06
54 EMBRYO DEVELOPMENT 39 894 2.958e-08 2.549e-06
55 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 21 303 3.435e-08 2.906e-06
56 TELENCEPHALON DEVELOPMENT 18 228 4.689e-08 3.896e-06
57 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 18 229 5.014e-08 4.093e-06
58 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 54 1517 5.68e-08 4.557e-06
59 MUSCLE STRUCTURE DEVELOPMENT 25 432 5.968e-08 4.64e-06
60 REGULATION OF CELL ADHESION 31 629 5.983e-08 4.64e-06
61 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 18 232 6.116e-08 4.665e-06
62 CELL PART MORPHOGENESIS 31 633 6.896e-08 5.175e-06
63 EMBRYONIC MORPHOGENESIS 28 539 9.163e-08 6.768e-06
64 ACTIN FILAMENT BASED PROCESS 25 450 1.304e-07 9.483e-06
65 REGULATION OF CELL DEATH 52 1472 1.327e-07 9.499e-06
66 CELL MOTILITY 36 835 1.405e-07 9.69e-06
67 POSITIVE REGULATION OF CATALYTIC ACTIVITY 53 1518 1.432e-07 9.69e-06
68 LOCALIZATION OF CELL 36 835 1.405e-07 9.69e-06
69 HEART PROCESS 11 85 1.458e-07 9.69e-06
70 CONNECTIVE TISSUE DEVELOPMENT 16 194 1.45e-07 9.69e-06
71 CARTILAGE DEVELOPMENT 14 147 1.501e-07 9.84e-06
72 REGULATION OF MUSCLE SYSTEM PROCESS 16 195 1.557e-07 1.006e-05
73 SKELETAL SYSTEM DEVELOPMENT 25 455 1.608e-07 1.025e-05
74 ORGAN MORPHOGENESIS 36 841 1.673e-07 1.052e-05
75 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 337 2.08e-07 1.291e-05
76 CELL JUNCTION ASSEMBLY 13 129 2.167e-07 1.301e-05
77 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 40 1004 2.181e-07 1.301e-05
78 EPITHELIAL CELL DIFFERENTIATION 26 495 2.171e-07 1.301e-05
79 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 59 1805 2.417e-07 1.424e-05
80 VASCULATURE DEVELOPMENT 25 469 2.844e-07 1.654e-05
81 WOUND HEALING 25 470 2.959e-07 1.7e-05
82 EPITHELIUM DEVELOPMENT 38 945 3.583e-07 2.033e-05
83 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 55 1656 4.041e-07 2.266e-05
84 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 38 957 4.894e-07 2.711e-05
85 RESPONSE TO OXYGEN CONTAINING COMPOUND 48 1381 6.911e-07 3.746e-05
86 REGULATION OF DENDRITE DEVELOPMENT 12 120 6.923e-07 3.746e-05
87 SYNAPSE ORGANIZATION 13 145 8.407e-07 4.477e-05
88 REGULATION OF HEART CONTRACTION 16 221 8.468e-07 4.477e-05
89 NEGATIVE REGULATION OF CELL COMMUNICATION 43 1192 1.079e-06 5.64e-05
90 REGULATION OF CELL SUBSTRATE ADHESION 14 173 1.104e-06 5.708e-05
91 REGULATION OF SYSTEM PROCESS 25 507 1.191e-06 6.09e-05
92 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 33 799 1.248e-06 6.311e-05
93 REGULATION OF CARDIAC MUSCLE CONTRACTION 9 66 1.284e-06 6.424e-05
94 REGULATION OF DEVELOPMENTAL GROWTH 18 289 1.569e-06 7.767e-05
95 NEURON PROJECTION GUIDANCE 15 205 1.636e-06 8.012e-05
96 CELLULAR RESPONSE TO HORMONE STIMULUS 26 552 1.697e-06 8.226e-05
97 NEGATIVE REGULATION OF LOCOMOTION 17 263 1.853e-06 8.89e-05
98 TUBE MORPHOGENESIS 19 323 1.882e-06 8.935e-05
99 RESPONSE TO HORMONE 35 893 1.921e-06 9.029e-05
100 REGULATION OF PHOSPHORUS METABOLIC PROCESS 52 1618 2.336e-06 0.0001087
101 CELL JUNCTION ORGANIZATION 14 185 2.452e-06 0.000113
102 SECOND MESSENGER MEDIATED SIGNALING 13 160 2.557e-06 0.0001167
103 NEGATIVE REGULATION OF GENE EXPRESSION 49 1493 2.676e-06 0.0001209
104 BLOOD VESSEL MORPHOGENESIS 20 364 2.864e-06 0.0001281
105 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 7 39 2.993e-06 0.0001326
106 REGULATION OF ORGAN GROWTH 9 73 3.045e-06 0.0001337
107 STEM CELL DIFFERENTIATION 14 190 3.354e-06 0.0001458
108 RESPONSE TO ORGANIC CYCLIC COMPOUND 35 917 3.467e-06 0.0001494
109 MUSCLE ORGAN DEVELOPMENT 17 277 3.738e-06 0.0001595
110 SYSTEM PROCESS 55 1785 4.07e-06 0.0001722
111 CELL SUBSTRATE JUNCTION ASSEMBLY 7 41 4.252e-06 0.0001783
112 REGULATION OF MEMBRANE POTENTIAL 19 343 4.522e-06 0.0001878
113 REGULATION OF ACTIN FILAMENT BASED PROCESS 18 312 4.61e-06 0.0001898
114 CARDIAC CHAMBER DEVELOPMENT 12 144 4.787e-06 0.0001954
115 REGULATION OF PROTEIN MODIFICATION PROCESS 53 1710 5.306e-06 0.0002147
116 REGULATION OF EPITHELIAL CELL PROLIFERATION 17 285 5.465e-06 0.0002192
117 REGULATION OF MUSCLE CONTRACTION 12 147 5.926e-06 0.0002317
118 REGULATION OF STRIATED MUSCLE CONTRACTION 9 79 5.92e-06 0.0002317
119 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 45 1360 5.856e-06 0.0002317
120 OLIGODENDROCYTE DIFFERENTIATION 8 60 5.988e-06 0.0002322
121 RESPONSE TO ABIOTIC STIMULUS 37 1024 6.272e-06 0.0002412
122 REGULATION OF ION HOMEOSTASIS 14 201 6.446e-06 0.0002458
123 MEMBRANE DEPOLARIZATION 8 61 6.794e-06 0.000257
124 GLIOGENESIS 13 175 6.873e-06 0.0002579
125 REGULATION OF MUSCLE TISSUE DEVELOPMENT 10 103 7.718e-06 0.0002873
126 MUSCLE CONTRACTION 15 233 7.873e-06 0.0002907
127 SENSORY ORGAN DEVELOPMENT 23 493 7.983e-06 0.0002925
128 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 37 1036 8.141e-06 0.0002937
129 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 37 1036 8.141e-06 0.0002937
130 REGULATION OF BLOOD CIRCULATION 17 295 8.613e-06 0.0003083
131 REGULATION OF CARTILAGE DEVELOPMENT 8 63 8.684e-06 0.0003084
132 TISSUE MORPHOGENESIS 24 533 9.156e-06 0.0003228
133 REGULATION OF CHONDROCYTE DIFFERENTIATION 7 46 9.435e-06 0.0003301
134 MUSCLE CELL DIFFERENTIATION 15 237 9.657e-06 0.0003353
135 TAXIS 22 464 9.797e-06 0.0003377
136 NEGATIVE REGULATION OF CELL DIFFERENTIATION 26 609 9.904e-06 0.0003388
137 DIVALENT INORGANIC CATION TRANSPORT 16 268 1.021e-05 0.0003467
138 RESPONSE TO MECHANICAL STIMULUS 14 210 1.064e-05 0.0003587
139 REGULATION OF SEQUESTERING OF CALCIUM ION 10 107 1.085e-05 0.0003632
140 PIGMENTATION 9 86 1.196e-05 0.0003975
141 EXTRACELLULAR STRUCTURE ORGANIZATION 17 304 1.274e-05 0.0004206
142 MUSCLE TISSUE DEVELOPMENT 16 275 1.407e-05 0.000461
143 MELANOCYTE DIFFERENTIATION 5 20 1.479e-05 0.0004812
144 REGULATION OF CELL JUNCTION ASSEMBLY 8 68 1.543e-05 0.0004987
145 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 39 1152 1.56e-05 0.0005007
146 GLIAL CELL DIFFERENTIATION 11 136 1.581e-05 0.0005012
147 POST EMBRYONIC DEVELOPMENT 9 89 1.583e-05 0.0005012
148 REGULATION OF ADHERENS JUNCTION ORGANIZATION 7 50 1.664e-05 0.0005232
149 HEMOSTASIS 17 311 1.71e-05 0.0005339
150 REGULATION OF CELL MATRIX ADHESION 9 90 1.734e-05 0.000538
151 REGULATION OF HOMEOSTATIC PROCESS 21 447 1.792e-05 0.0005522
152 COGNITION 15 251 1.906e-05 0.0005798
153 OSSIFICATION 15 251 1.906e-05 0.0005798
154 REGULATION OF GROWTH 26 633 1.933e-05 0.000584
155 REGULATION OF GTPASE ACTIVITY 27 673 2.018e-05 0.0006059
156 NEGATIVE REGULATION OF CELL DEATH 32 872 2.036e-05 0.0006072
157 CARDIAC MUSCLE TISSUE DEVELOPMENT 11 140 2.077e-05 0.0006155
158 SINGLE ORGANISM BEHAVIOR 19 384 2.222e-05 0.0006516
159 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 32 876 2.227e-05 0.0006516
160 ACTIN FILAMENT BASED MOVEMENT 9 93 2.262e-05 0.0006579
161 ACTION POTENTIAL 9 94 2.466e-05 0.0007127
162 CARDIAC MUSCLE CELL ACTION POTENTIAL 6 37 2.863e-05 0.0008182
163 REGULATION OF TRANSMEMBRANE TRANSPORT 20 426 2.866e-05 0.0008182
164 RESPONSE TO LIPID 32 888 2.902e-05 0.0008232
165 RESPONSE TO EXTERNAL STIMULUS 53 1821 3.064e-05 0.0008638
166 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 5 23 3.082e-05 0.0008638
167 NEURAL CREST CELL DIFFERENTIATION 8 75 3.188e-05 0.0008884
168 RESPONSE TO DRUG 20 431 3.379e-05 0.0009358
169 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 10 122 3.425e-05 0.000943
170 REGULATION OF HYDROLASE ACTIVITY 42 1327 3.514e-05 0.0009619
171 REGULATION OF DENDRITIC SPINE DEVELOPMENT 7 56 3.552e-05 0.0009664
172 STRIATED MUSCLE CONTRACTION 9 99 3.735e-05 0.00101
173 MORPHOGENESIS OF AN EPITHELIUM 19 400 3.877e-05 0.001043
174 CIRCULATORY SYSTEM PROCESS 18 366 3.95e-05 0.00105
175 PROTEIN PHOSPHORYLATION 33 944 3.946e-05 0.00105
176 REGULATION OF OSSIFICATION 12 178 4.063e-05 0.001074
177 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 207 4.099e-05 0.001077
178 POSITIVE REGULATION OF HYDROLASE ACTIVITY 32 905 4.179e-05 0.001092
179 DEVELOPMENTAL PIGMENTATION 6 40 4.535e-05 0.001179
180 DENDRITE DEVELOPMENT 8 79 4.658e-05 0.001204
181 TUBE DEVELOPMENT 23 552 4.729e-05 0.001211
182 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 5 25 4.736e-05 0.001211
183 LOCOMOTORY BEHAVIOR 12 181 4.783e-05 0.001216
184 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 23 554 4.997e-05 0.00126
185 VASCULOGENESIS 7 59 5.009e-05 0.00126
186 REGULATION OF MUSCLE ORGAN DEVELOPMENT 9 103 5.113e-05 0.001279
187 HEART MORPHOGENESIS 13 212 5.243e-05 0.001305
188 CHONDROCYTE DIFFERENTIATION 7 60 5.591e-05 0.001384
189 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 45 1492 5.748e-05 0.001415
190 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 37 1135 5.808e-05 0.001422
191 REGULATION OF HEART GROWTH 6 42 6.028e-05 0.001469
192 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 4 14 6.318e-05 0.001531
193 CARDIAC VENTRICLE DEVELOPMENT 9 106 6.409e-05 0.001545
194 FOREBRAIN CELL MIGRATION 7 62 6.923e-05 0.001652
195 CARDIAC VENTRICLE MORPHOGENESIS 7 62 6.923e-05 0.001652
196 REGULATION OF CARDIAC MUSCLE CELL CONTRACTION 5 27 7.005e-05 0.001663
197 POSITIVE REGULATION OF RESPONSE TO STIMULUS 54 1929 7.265e-05 0.001707
198 TISSUE MIGRATION 8 84 7.249e-05 0.001707
199 CELLULAR RESPONSE TO LIPID 20 457 7.607e-05 0.001773
200 MESENCHYMAL CELL DIFFERENTIATION 10 134 7.619e-05 0.001773
201 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 26 689 7.946e-05 0.001839
202 SINGLE ORGANISM CELL ADHESION 20 459 8.073e-05 0.00186
203 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 4 15 8.504e-05 0.00194
204 POSITIVE REGULATION OF DENDRITE DEVELOPMENT 7 64 8.502e-05 0.00194
205 NEURON MIGRATION 9 110 8.557e-05 0.001942
206 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 9 111 9.18e-05 0.002073
207 REGULATION OF TRANSPORT 51 1804 9.289e-05 0.002088
208 REGULATION OF OSTEOBLAST DIFFERENTIATION 9 112 9.84e-05 0.002201
209 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 29 0.0001003 0.002222
210 PIGMENT CELL DIFFERENTIATION 5 29 0.0001003 0.002222
211 REGULATION OF CELL SHAPE 10 139 0.0001035 0.002283
212 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 0.0001043 0.00229
213 REGULATION OF BODY FLUID LEVELS 21 506 0.0001067 0.00233
214 EYE DEVELOPMENT 16 326 0.0001082 0.002352
215 NEGATIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 4 16 0.0001119 0.002422
216 REGULATION OF TRANSPORTER ACTIVITY 12 198 0.0001132 0.002439
217 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 5 30 0.0001188 0.002546
218 NEPHRON DEVELOPMENT 9 115 0.0001206 0.002575
219 RESPONSE TO GROWTH FACTOR 20 475 0.0001282 0.002723
220 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 6 48 0.0001298 0.002733
221 DIGESTIVE TRACT MORPHOGENESIS 6 48 0.0001298 0.002733
222 REGULATION OF VASCULATURE DEVELOPMENT 13 233 0.0001362 0.002856
223 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 8 92 0.0001382 0.002883
224 UROGENITAL SYSTEM DEVELOPMENT 15 299 0.0001391 0.002889
225 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 4 17 0.0001445 0.002988
226 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 6 49 0.0001459 0.003004
227 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 8 93 0.000149 0.003054
228 MODULATION OF SYNAPTIC TRANSMISSION 15 301 0.0001496 0.003054
229 POSITIVE REGULATION OF KINASE ACTIVITY 20 482 0.0001557 0.003164
230 NEGATIVE REGULATION OF CELL DEVELOPMENT 15 303 0.0001608 0.003254
231 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 5 32 0.0001634 0.00329
232 ENDODERM DEVELOPMENT 7 71 0.000165 0.003309
233 REGULATION OF CELLULAR COMPONENT BIOGENESIS 27 767 0.0001815 0.003626
234 CARDIOCYTE DIFFERENTIATION 8 96 0.000186 0.003698
235 CELL CELL ADHESION 23 608 0.0001983 0.003926
236 MULTICELLULAR ORGANISMAL SIGNALING 9 123 0.0002013 0.003966
237 REGULATION OF CHEMOTAXIS 11 180 0.000202 0.003966
238 POSITIVE REGULATION OF CELL COMMUNICATION 44 1532 0.0002104 0.004114
239 RESPONSE TO NITROGEN COMPOUND 29 859 0.0002126 0.004133
240 RESPONSE TO OXYGEN LEVELS 15 311 0.0002133 0.004133
241 CARDIAC MUSCLE CELL DIFFERENTIATION 7 74 0.0002141 0.004133
242 REGULATION OF MUSCLE CELL DIFFERENTIATION 10 152 0.0002161 0.004155
243 REGULATION OF KINASE ACTIVITY 27 776 0.0002188 0.004189
244 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 14 278 0.000222 0.004233
245 POSITIVE REGULATION OF LOCOMOTION 18 420 0.0002235 0.004245
246 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 6 53 0.0002267 0.00427
247 SKELETAL MUSCLE CELL DIFFERENTIATION 6 53 0.0002267 0.00427
248 PALLIUM DEVELOPMENT 10 153 0.0002279 0.004275
249 REGULATION OF CARDIAC MUSCLE CONTRACTION BY REGULATION OF THE RELEASE OF SEQUESTERED CALCIUM ION 4 19 0.0002292 0.004284
250 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 7 75 0.0002328 0.004334
251 ION TRANSMEMBRANE TRANSPORT 28 822 0.0002366 0.004386
252 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 23 616 0.0002391 0.004398
253 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 20 498 0.0002391 0.004398
254 REGULATION OF MAPK CASCADE 24 660 0.0002591 0.004746
255 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 10 156 0.0002666 0.004864
256 MUSCLE CELL DEVELOPMENT 9 128 0.0002715 0.004935
257 REGULATION OF BMP SIGNALING PATHWAY 7 77 0.0002743 0.004967
258 NEGATIVE REGULATION OF CELL JUNCTION ASSEMBLY 4 20 0.0002828 0.005081
259 RELAXATION OF MUSCLE 4 20 0.0002828 0.005081
260 CELLULAR RESPONSE TO NITROGEN COMPOUND 20 505 0.0002866 0.005128
261 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 6 56 0.0003076 0.005464
262 TRANSMEMBRANE TRANSPORT 34 1098 0.0003065 0.005464
263 CARDIAC CHAMBER MORPHOGENESIS 8 104 0.0003226 0.005664
264 LEARNING 9 131 0.0003226 0.005664
265 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 9 131 0.0003226 0.005664
266 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 5 37 0.0003306 0.005783
267 CALCIUM ION TRANSPORT 12 223 0.0003407 0.005916
268 NEGATIVE REGULATION OF CELL ADHESION 12 223 0.0003407 0.005916
269 CHONDROCYTE DEVELOPMENT 4 21 0.0003449 0.005966
270 REGULATION OF ION TRANSPORT 22 592 0.0003474 0.005987
271 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 162 0.0003606 0.006192
272 POSITIVE REGULATION OF ORGAN GROWTH 5 38 0.0003756 0.006425
273 NEGATIVE REGULATION OF MUSCLE CONTRACTION 4 22 0.0004161 0.007066
274 CELL CELL SIGNALING INVOLVED IN CARDIAC CONDUCTION 4 22 0.0004161 0.007066
275 REGULATION OF PHOSPHOLIPASE C ACTIVITY 5 39 0.0004251 0.007179
276 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 262 0.0004258 0.007179
277 EMBRYONIC ORGAN DEVELOPMENT 17 406 0.0004336 0.007284
278 REGULATION OF EPITHELIAL CELL MIGRATION 10 166 0.0004375 0.007305
279 RESPIRATORY SYSTEM DEVELOPMENT 11 197 0.000438 0.007305
280 DEVELOPMENTAL GROWTH 15 333 0.0004405 0.00732
281 RESPONSE TO HYDROGEN PEROXIDE 8 109 0.0004433 0.00734
282 HINDBRAIN DEVELOPMENT 9 137 0.0004487 0.007377
283 SKELETAL MUSCLE ORGAN DEVELOPMENT 9 137 0.0004487 0.007377
284 POSITIVE REGULATION OF CELL PROLIFERATION 27 814 0.0004617 0.007564
285 ION TRANSPORT 37 1262 0.0004724 0.007698
286 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 9 138 0.0004732 0.007698
287 REGULATION OF AXONOGENESIS 10 168 0.0004808 0.007796
288 APPENDAGE DEVELOPMENT 10 169 0.0005038 0.008111
289 LIMB DEVELOPMENT 10 169 0.0005038 0.008111
290 SKELETAL SYSTEM MORPHOGENESIS 11 201 0.0005187 0.008322
291 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 62 0.0005364 0.008576
292 PLATELET ACTIVATION 9 142 0.0005824 0.009255
293 NEUROEPITHELIAL CELL DIFFERENTIATION 6 63 0.0005847 0.009255
294 REGULATION OF MUSCLE ADAPTATION 6 63 0.0005847 0.009255
295 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 4 24 0.000589 0.009258
296 NEGATIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 24 0.000589 0.009258
297 STRIATED MUSCLE CELL DIFFERENTIATION 10 173 0.0006049 0.009444
298 DENDRITE MORPHOGENESIS 5 42 0.0006033 0.009444
299 REGULATION OF STEM CELL PROLIFERATION 7 88 0.000621 0.009664
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATORY REGION NUCLEIC ACID BINDING 40 818 7.716e-10 7.168e-07
2 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 33 629 4.791e-09 1.484e-06
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 49 1199 3.466e-09 1.484e-06
4 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 22 315 1.401e-08 3.253e-06
5 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 2.897e-08 5.383e-06
6 MACROMOLECULAR COMPLEX BINDING 51 1399 6.697e-08 1.037e-05
7 SEQUENCE SPECIFIC DNA BINDING 41 1037 1.857e-07 2.465e-05
8 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 17 226 2.23e-07 2.589e-05
9 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 13 133 3.099e-07 3.198e-05
10 ACTIVATING TRANSCRIPTION FACTOR BINDING 9 57 3.554e-07 3.301e-05
11 CYTOSKELETAL PROTEIN BINDING 32 819 5.793e-06 0.0004485
12 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 26 588 5.33e-06 0.0004485
13 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 9 90 1.734e-05 0.001239
14 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 20 417 2.116e-05 0.001404
15 DOUBLE STRANDED DNA BINDING 29 764 2.75e-05 0.001703
16 ACTIN BINDING 19 393 3.051e-05 0.001772
17 CORE PROMOTER PROXIMAL REGION DNA BINDING 18 371 4.71e-05 0.002574
18 MOLECULAR FUNCTION REGULATOR 42 1353 5.47e-05 0.002823
19 PROTEIN COMPLEX BINDING 32 935 7.731e-05 0.00378
20 DIVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 11 167 0.0001043 0.004846
21 TRANSCRIPTION COACTIVATOR ACTIVITY 15 296 0.0001245 0.005508
22 ACTIN FILAMENT BINDING 9 121 0.0001778 0.006666
23 PROTEIN KINASE ACTIVITY 24 640 0.0001645 0.006666
24 INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 21 527 0.0001866 0.006666
25 TUBULIN BINDING 14 273 0.0001841 0.006666
26 TRANSCRIPTION FACTOR BINDING 21 524 0.0001726 0.006666
27 ENZYME BINDING 48 1737 0.0002602 0.008952
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 54 1265 9.794e-11 2.073e-08
2 NEURON PROJECTION 46 942 3.719e-11 2.073e-08
3 CELL PROJECTION 67 1786 1.065e-10 2.073e-08
4 SOMATODENDRITIC COMPARTMENT 35 650 8.006e-10 1.169e-07
5 CELL JUNCTION 47 1151 7.762e-09 9.066e-07
6 SYNAPSE 35 754 3.548e-08 2.96e-06
7 DENDRITE 26 451 3.472e-08 2.96e-06
8 CELL BODY 26 494 2.088e-07 1.524e-05
9 MEMBRANE REGION 42 1134 7.386e-07 4.793e-05
10 NEURON SPINE 11 121 5.158e-06 0.0003012
11 MEMBRANE MICRODOMAIN 17 288 6.278e-06 0.0003333
12 SYNAPSE PART 26 610 1.019e-05 0.000496
13 PLASMA MEMBRANE PROTEIN COMPLEX 23 510 1.376e-05 0.0006182
14 ACTIN CYTOSKELETON 21 444 1.621e-05 0.0006763
15 POSTSYNAPSE 19 378 1.787e-05 0.0006959
16 CELL LEADING EDGE 18 350 2.195e-05 0.0008012
17 SARCOLEMMA 10 125 4.221e-05 0.00145
18 CYTOSKELETON 55 1967 6.355e-05 0.002062
19 T TUBULE 6 45 8.981e-05 0.00276
20 CELL SUBSTRATE JUNCTION 18 398 0.0001151 0.003361
21 CELL CELL JUNCTION 17 383 0.0002213 0.005875
22 CELL PROJECTION PART 31 946 0.0002169 0.005875
23 RUFFLE 10 156 0.0002666 0.006769

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 15 200 1.2e-06 0.0002034
2 hsa04540_Gap_junction 10 90 2.26e-06 0.0002034
3 hsa04971_Gastric_acid_secretion 9 74 3.417e-06 0.000205
4 hsa04270_Vascular_smooth_muscle_contraction 10 116 2.211e-05 0.0008207
5 hsa04151_PI3K_AKT_signaling_pathway 18 351 2.28e-05 0.0008207
6 hsa04970_Salivary_secretion 8 89 0.0001094 0.003282
7 hsa04720_Long.term_potentiation 7 70 0.0001508 0.00342
8 hsa04010_MAPK_signaling_pathway 14 268 0.000152 0.00342
9 hsa04912_GnRH_signaling_pathway 8 101 0.0002641 0.004753
10 hsa04916_Melanogenesis 8 101 0.0002641 0.004753
11 hsa04512_ECM.receptor_interaction 7 85 0.0005035 0.008026
12 hsa04014_Ras_signaling_pathway 12 236 0.0005662 0.008026
13 hsa04012_ErbB_signaling_pathway 7 87 0.0005797 0.008026
14 hsa04730_Long.term_depression 6 70 0.001025 0.01318
15 hsa04810_Regulation_of_actin_cytoskeleton 10 214 0.002969 0.03563
16 hsa04972_Pancreatic_secretion 6 101 0.006494 0.07306
17 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 3 26 0.008665 0.09139
18 hsa04020_Calcium_signaling_pathway 8 177 0.009139 0.09139
19 hsa04390_Hippo_signaling_pathway 7 154 0.01393 0.132
20 hsa04666_Fc_gamma_R.mediated_phagocytosis 5 95 0.02035 0.1771
21 hsa04360_Axon_guidance 6 130 0.02067 0.1771
22 hsa04514_Cell_adhesion_molecules_.CAMs. 6 136 0.02513 0.2056
23 hsa04960_Aldosterone.regulated_sodium_reabsorption 3 42 0.03158 0.242
24 hsa04520_Adherens_junction 4 73 0.03227 0.242
25 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.03558 0.2498
26 hsa04260_Cardiac_muscle_contraction 4 77 0.03815 0.2498
27 hsa04310_Wnt_signaling_pathway 6 151 0.03897 0.2498
28 hsa04070_Phosphatidylinositol_signaling_system 4 78 0.03971 0.2498
29 hsa04114_Oocyte_meiosis 5 114 0.04024 0.2498
30 hsa04380_Osteoclast_differentiation 5 128 0.06051 0.3631
31 hsa04530_Tight_junction 5 133 0.06893 0.4002
32 hsa04910_Insulin_signaling_pathway 5 138 0.07796 0.4386
33 hsa04660_T_cell_receptor_signaling_pathway 4 108 0.1028 0.5609
34 hsa04976_Bile_secretion 3 71 0.1118 0.5818
35 hsa04630_Jak.STAT_signaling_pathway 5 155 0.1131 0.5818
36 hsa04670_Leukocyte_transendothelial_migration 4 117 0.1274 0.6317
37 hsa04370_VEGF_signaling_pathway 3 76 0.1298 0.6317
38 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.1411 0.6684
39 hsa04722_Neurotrophin_signaling_pathway 4 127 0.1573 0.7261
40 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.1632 0.7343
41 hsa04914_Progesterone.mediated_oocyte_maturation 3 87 0.1726 0.7577
42 hsa04210_Apoptosis 3 89 0.1808 0.7747
43 hsa04150_mTOR_signaling_pathway 2 52 0.2107 0.8429
44 hsa04340_Hedgehog_signaling_pathway 2 56 0.235 0.8812
45 hsa00230_Purine_metabolism 4 162 0.2772 1
46 hsa04920_Adipocytokine_signaling_pathway 2 68 0.3082 1
47 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.3504 1
48 hsa04062_Chemokine_signaling_pathway 4 189 0.3775 1
49 hsa04974_Protein_digestion_and_absorption 2 81 0.3858 1
50 hsa04650_Natural_killer_cell_mediated_cytotoxicity 3 136 0.388 1
51 hsa04145_Phagosome 3 156 0.4748 1
52 hsa04142_Lysosome 2 121 0.5944 1
53 hsa04144_Endocytosis 3 203 0.652 1
54 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.6695 1
55 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.7665 1
56 hsa04740_Olfactory_transduction 2 388 0.9885 1

Quest ID: f5013c8bc92aa832928c3d5e3e71ddc4