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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p APC2 -1.37 0 1.14 0.00012 TargetScan -0.46 0 NA
2 hsa-miR-15b-3p CAMK2A 0.8 0.0004 -1.98 0 mirMAP -0.33 0 NA
3 hsa-miR-19b-1-5p CAMK2A 1.71 0 -1.98 0 mirMAP -0.34 0 NA
4 hsa-miR-21-3p CAMK2A 2.54 0 -1.98 0 MirTarget -0.32 0 NA
5 hsa-miR-25-3p CAMK2A 0.36 0.01637 -1.98 0 MirTarget -0.43 1.0E-5 NA
6 hsa-miR-7-1-3p CAMK2A 2.61 0 -1.98 0 MirTarget -0.32 0 NA
7 hsa-miR-24-3p CAMK2B -0.04 0.78587 1.37 0.0148 MirTarget -0.42 0.0381 NA
8 hsa-miR-29a-3p CAMK2B 0.1 0.5732 1.37 0.0148 mirMAP -0.57 8.0E-5 NA
9 hsa-miR-15b-5p CCND1 -1.26 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.3 0 NA
10 hsa-miR-16-5p CCND1 0.75 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.37 0 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
11 hsa-miR-17-5p CCND1 2.07 0 -0.3 0.2554 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.31 0 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene
12 hsa-miR-186-5p CCND1 0.85 0 -0.3 0.2554 mirMAP -0.38 1.0E-5 NA
13 hsa-miR-19b-1-5p CCND1 1.71 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase -0.3 0 NA
14 hsa-miR-374a-5p CCND1 -0.2 0.29808 -0.3 0.2554 MirTarget -0.31 1.0E-5 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression
15 hsa-miR-92a-3p CCND1 -0.14 0.49341 -0.3 0.2554 miRNAWalker2 validate -0.34 0 NA
16 hsa-miR-93-5p CCND1 1.51 0 -0.3 0.2554 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 0 NA
17 hsa-miR-106b-5p CCND2 1.47 0 -1.64 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.38 0 NA
18 hsa-miR-17-5p CCND2 2.07 0 -1.64 0 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.37 0 NA
19 hsa-miR-182-5p CCND2 3.22 0 -1.64 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0 NA
20 hsa-miR-183-5p CCND2 2.39 0 -1.64 0 miRNATAP -0.41 0 NA
21 hsa-miR-186-5p CCND2 0.85 0 -1.64 0 mirMAP; miRNATAP -0.36 1.0E-5 NA
22 hsa-miR-93-5p CCND2 1.51 0 -1.64 0 miRNATAP -0.41 0 NA
23 hsa-miR-96-5p CCND2 3.04 0 -1.64 0 TargetScan; miRNATAP -0.36 0 NA
24 hsa-miR-146a-5p CXXC4 0.68 0.01053 0.06 0.89857 MirTarget -0.35 1.0E-5 NA
25 hsa-miR-146b-5p CXXC4 1.09 1.0E-5 0.06 0.89857 MirTarget; miRNATAP -0.46 0 NA
26 hsa-miR-193a-3p DAAM2 0.55 0.0319 -1.64 0 miRanda -0.32 0 NA
27 hsa-miR-421 DAAM2 0.17 0.53528 -1.64 0 PITA; miRanda -0.39 0 NA
28 hsa-miR-590-3p DAAM2 0.84 0.00129 -1.64 0 miRanda; mirMAP -0.39 0 NA
29 hsa-miR-107 DKK1 0.66 0 -0.08 0.90908 miRanda -0.58 0.02089 NA
30 hsa-miR-29a-3p DKK1 0.1 0.5732 -0.08 0.90908 miRNAWalker2 validate; miRTarBase -0.38 0.0397 NA
31 hsa-miR-324-5p DKK2 1.07 5.0E-5 -2.46 0 miRanda -0.32 0 NA
32 hsa-miR-590-5p DKK2 2.07 0 -2.46 0 miRanda -0.43 0 NA
33 hsa-miR-429 FOSL1 2.38 0 -0.17 0.70192 miRanda; miRNATAP -0.3 0 NA
34 hsa-miR-186-5p FZD1 0.85 0 -0.36 0.09979 mirMAP -0.33 1.0E-5 NA
35 hsa-miR-15a-5p FZD10 1.63 0 -0.8 0.14751 miRNATAP -0.34 0.01212 NA
36 hsa-miR-23a-3p FZD3 0.11 0.39309 0.79 0.00088 MirTarget -0.35 5.0E-5 NA
37 hsa-miR-361-5p FZD3 0.21 0.0801 0.79 0.00088 miRanda; miRNATAP -0.34 0.00018 NA
38 hsa-miR-130b-3p MAPK10 1.83 0 -1.85 0 miRNATAP -0.54 0 NA
39 hsa-miR-590-3p MAPK10 0.84 0.00129 -1.85 0 miRanda; mirMAP -0.49 0 NA
40 hsa-miR-590-5p MAPK10 2.07 0 -1.85 0 PITA; miRanda; miRNATAP -0.56 0 NA
41 hsa-miR-185-5p NFATC2 1.14 0 -1.18 0.0004 MirTarget -0.36 0.00019 NA
42 hsa-miR-186-5p NFATC2 0.85 0 -1.18 0.0004 mirMAP -0.34 0.00202 NA
43 hsa-miR-19a-3p NFATC2 2.12 0 -1.18 0.0004 mirMAP -0.34 0 NA
44 hsa-miR-19b-3p NFATC2 2.11 0 -1.18 0.0004 mirMAP -0.38 0 NA
45 hsa-miR-21-5p NKD1 4.38 0 -1.73 0 mirMAP -0.39 0 NA
46 hsa-miR-140-3p PLCB1 -1.11 0 0.16 0.60449 PITA -0.39 2.0E-5 NA
47 hsa-miR-183-5p PLCB4 2.39 0 -1.83 7.0E-5 miRNATAP -0.32 6.0E-5 NA
48 hsa-miR-590-3p PLCB4 0.84 0.00129 -1.83 7.0E-5 miRanda -0.35 0.00036 NA
49 hsa-miR-96-5p PLCB4 3.04 0 -1.83 7.0E-5 TargetScan; miRNATAP -0.31 6.0E-5 NA
50 hsa-miR-141-3p PRICKLE1 3.37 0 -1.65 0 TargetScan -0.35 0 NA
51 hsa-miR-17-5p PRICKLE1 2.07 0 -1.65 0 miRNAWalker2 validate -0.37 0 NA
52 hsa-miR-148b-3p PRICKLE2 0.48 0.00265 -1.56 0 MirTarget; miRNATAP -0.35 0 NA
53 hsa-miR-590-5p PRICKLE2 2.07 0 -1.56 0 MirTarget; PITA; miRanda -0.34 0 NA
54 hsa-miR-181c-5p PRKCA 0.53 0.01259 -0.19 0.47108 mirMAP -0.33 0 NA
55 hsa-miR-2110 PRKCG -1.92 0 1.67 0.00027 MirTarget -0.31 6.0E-5 NA
56 hsa-miR-30c-2-3p RAC3 -3.11 0 1.83 0 miRNAWalker2 validate -0.37 0 NA
57 hsa-miR-146b-5p SFRP1 1.09 1.0E-5 -2.09 5.0E-5 MirTarget -0.53 0 NA
58 hsa-miR-16-1-3p SFRP1 1.5 0 -2.09 5.0E-5 MirTarget -0.48 6.0E-5 NA
59 hsa-miR-29a-5p SFRP1 1.9 0 -2.09 5.0E-5 mirMAP -0.55 0 NA
60 hsa-miR-96-5p SFRP1 3.04 0 -2.09 5.0E-5 mirMAP -0.38 2.0E-5 NA
61 hsa-miR-26b-5p SFRP4 0.72 5.0E-5 0.5 0.21527 miRNAWalker2 validate -0.31 0.00346 NA
62 hsa-miR-127-5p WIF1 2.05 0 -5.68 0 PITA; miRNATAP -0.49 0 NA
63 hsa-miR-28-5p WIF1 1.2 0 -5.68 0 miRanda -0.75 0.00387 NA
64 hsa-miR-590-3p WIF1 0.84 0.00129 -5.68 0 PITA; miRanda; mirMAP -0.52 0.00196 NA
65 hsa-miR-590-3p WNT11 0.84 0.00129 -2.02 0 miRanda -0.37 1.0E-5 NA
66 hsa-miR-181a-5p WNT16 -0.38 0.05621 0.42 0.38122 miRNAWalker2 validate; MirTarget -0.42 0.00021 NA
67 hsa-miR-181b-5p WNT16 0.67 0.00024 0.42 0.38122 MirTarget -0.4 0.00092 NA
68 hsa-miR-335-3p WNT2 1.51 0 -1.62 0 mirMAP -0.42 0 NA
69 hsa-miR-130b-3p WNT2B 1.83 0 -1.79 0 MirTarget -0.34 0 NA
70 hsa-miR-107 WNT3A 0.66 0 -5.45 0 MirTarget; PITA; miRanda; miRNATAP -0.6 0.00204 NA
71 hsa-miR-128-3p WNT3A 1.04 0 -5.45 0 miRNAWalker2 validate -0.73 0 27341528 AurkA controls self renewal of breast cancer initiating cells promoting wnt3a stabilization through suppression of miR 128; Interestingly we found that AurkA suppressed the expression of miR-128 inhibitor of wnt3a mRNA stabilization
72 hsa-miR-16-2-3p WNT5A 0.5 0.02636 -0.37 0.19306 MirTarget; mirMAP -0.37 0 NA
73 hsa-miR-186-5p WNT5A 0.85 0 -0.37 0.19306 miRNAWalker2 validate; mirMAP; miRNATAP -0.42 1.0E-5 NA
74 hsa-miR-576-5p WNT5A 1.03 0 -0.37 0.19306 mirMAP -0.4 0 NA
75 hsa-miR-92a-3p WNT5A -0.14 0.49341 -0.37 0.19306 miRNAWalker2 validate -0.36 0 NA
76 hsa-miR-107 WNT7A 0.66 0 -4.45 0 MirTarget; miRanda -1.04 1.0E-5 NA
77 hsa-miR-15a-5p WNT7A 1.63 0 -4.45 0 MirTarget -0.37 0.02487 NA
78 hsa-miR-16-5p WNT7A 0.75 0 -4.45 0 MirTarget -0.55 0.00371 NA
79 hsa-miR-374a-3p WNT7A 1.74 0 -4.45 0 MirTarget -0.32 0.01117 NA
80 hsa-miR-28-5p WNT9A 1.2 0 -1.71 0 mirMAP -0.41 3.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 24 351 3.7e-35 1.721e-31
2 REGULATION OF WNT SIGNALING PATHWAY 17 310 2.04e-22 4.746e-19
3 CANONICAL WNT SIGNALING PATHWAY 12 95 3.232e-20 5.012e-17
4 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 14 236 7.775e-19 9.044e-16
5 NON CANONICAL WNT SIGNALING PATHWAY 12 140 4.116e-18 3.307e-15
6 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 13 197 4.265e-18 3.307e-15
7 REGULATION OF EMBRYONIC DEVELOPMENT 10 114 2.829e-15 1.88e-12
8 REGULATION OF ORGAN MORPHOGENESIS 12 242 3.247e-15 1.889e-12
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 20 1672 1.107e-13 4.683e-11
10 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 10 162 1.019e-13 4.683e-11
11 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 17 1021 9.776e-14 4.683e-11
12 REGULATION OF CELL DIFFERENTIATION 19 1492 2.147e-13 8.325e-11
13 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 17 1142 6.01e-13 2.151e-10
14 CELL FATE COMMITMENT 10 227 3.006e-12 9.325e-10
15 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 9 152 2.971e-12 9.325e-10
16 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 8 110 1.042e-11 3.032e-09
17 POSITIVE REGULATION OF CELL DIFFERENTIATION 14 823 2.314e-11 6.334e-09
18 NEURON DIFFERENTIATION 14 874 5.145e-11 1.33e-08
19 POSITIVE REGULATION OF CELL COMMUNICATION 17 1532 6.555e-11 1.605e-08
20 EMBRYO DEVELOPMENT 14 894 6.943e-11 1.615e-08
21 MIDBRAIN DEVELOPMENT 7 90 1.436e-10 3.182e-08
22 NEUROGENESIS 16 1402 2.057e-10 4.351e-08
23 POSITIVE REGULATION OF RESPONSE TO STIMULUS 18 1929 2.348e-10 4.75e-08
24 ORGAN MORPHOGENESIS 13 841 4.792e-10 9.142e-08
25 RESPONSE TO RETINOIC ACID 7 107 4.912e-10 9.142e-08
26 TISSUE MORPHOGENESIS 11 533 7.138e-10 1.277e-07
27 EMBRYONIC MORPHOGENESIS 11 539 8.031e-10 1.384e-07
28 DOPAMINERGIC NEURON DIFFERENTIATION 5 28 9.979e-10 1.658e-07
29 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 11 554 1.072e-09 1.662e-07
30 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 119 1.04e-09 1.662e-07
31 CELLULAR RESPONSE TO RETINOIC ACID 6 65 1.165e-09 1.749e-07
32 REGULATION OF ORGAN FORMATION 5 32 2.035e-09 2.959e-07
33 NEGATIVE REGULATION OF CELL COMMUNICATION 14 1192 2.988e-09 4.213e-07
34 REGULATION OF PROTEIN MODIFICATION PROCESS 16 1710 3.787e-09 5.182e-07
35 SENSORY ORGAN MORPHOGENESIS 8 239 5.137e-09 6.829e-07
36 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1492 5.498e-09 7.106e-07
37 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 5 39 5.769e-09 7.254e-07
38 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 6.323e-09 7.743e-07
39 RESPONSE TO LIPID 12 888 1.211e-08 1.444e-06
40 HEAD DEVELOPMENT 11 709 1.398e-08 1.626e-06
41 CELLULAR RESPONSE TO ACID CHEMICAL 7 175 1.535e-08 1.742e-06
42 MORPHOGENESIS OF AN EPITHELIUM 9 400 1.577e-08 1.748e-06
43 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 14 1360 1.619e-08 1.752e-06
44 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 1135 1.794e-08 1.897e-06
45 RESPONSE TO OXYGEN CONTAINING COMPOUND 14 1381 1.967e-08 2.034e-06
46 PATTERN SPECIFICATION PROCESS 9 418 2.306e-08 2.332e-06
47 EPITHELIUM DEVELOPMENT 12 945 2.416e-08 2.392e-06
48 STEM CELL DIFFERENTIATION 7 190 2.707e-08 2.624e-06
49 EPITHELIAL TO MESENCHYMAL TRANSITION 5 56 3.749e-08 3.56e-06
50 RESPONSE TO ACID CHEMICAL 8 319 4.857e-08 4.455e-06
51 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 11 801 4.883e-08 4.455e-06
52 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 12 1036 6.655e-08 5.734e-06
53 POSITIVE REGULATION OF MOLECULAR FUNCTION 15 1791 6.468e-08 5.734e-06
54 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 1036 6.655e-08 5.734e-06
55 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 6 134 9.318e-08 7.868e-06
56 SENSORY ORGAN DEVELOPMENT 9 493 9.47e-08 7.868e-06
57 EYE MORPHOGENESIS 6 136 1.018e-07 8.308e-06
58 CENTRAL NERVOUS SYSTEM DEVELOPMENT 11 872 1.157e-07 9.281e-06
59 AXIS ELONGATION 4 27 1.188e-07 9.369e-06
60 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 513 1.328e-07 1.03e-05
61 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 8 365 1.367e-07 1.043e-05
62 REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1618 1.44e-07 1.081e-05
63 NEURAL TUBE DEVELOPMENT 6 149 1.75e-07 1.292e-05
64 SOMITE DEVELOPMENT 5 78 2.018e-07 1.467e-05
65 TUBE DEVELOPMENT 9 552 2.467e-07 1.766e-05
66 REGULATION OF JNK CASCADE 6 159 2.569e-07 1.811e-05
67 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 4 33 2.75e-07 1.91e-05
68 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 11 957 2.95e-07 2.018e-05
69 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 10 750 3e-07 2.023e-05
70 PALATE DEVELOPMENT 5 85 3.109e-07 2.04e-05
71 BRAIN MORPHOGENESIS 4 34 3.113e-07 2.04e-05
72 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 6 166 3.313e-07 2.141e-05
73 CELL CELL SIGNALING 10 767 3.687e-07 2.35e-05
74 REGULATION OF CELL DEATH 13 1472 3.782e-07 2.378e-05
75 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 4.29e-07 2.661e-05
76 REGULATION OF CELL PROLIFERATION 13 1496 4.556e-07 2.789e-05
77 CARDIOVASCULAR SYSTEM DEVELOPMENT 10 788 4.726e-07 2.819e-05
78 CIRCULATORY SYSTEM DEVELOPMENT 10 788 4.726e-07 2.819e-05
79 NEURAL TUBE FORMATION 5 94 5.146e-07 3.031e-05
80 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 10 799 5.366e-07 3.095e-05
81 TISSUE DEVELOPMENT 13 1518 5.388e-07 3.095e-05
82 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 6.361e-07 3.61e-05
83 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 4 42 7.441e-07 4.026e-05
84 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 11 7.338e-07 4.026e-05
85 MESENCHYME DEVELOPMENT 6 190 7.321e-07 4.026e-05
86 CAMERA TYPE EYE MORPHOGENESIS 5 101 7.363e-07 4.026e-05
87 CELLULAR RESPONSE TO LIPID 8 457 7.532e-07 4.028e-05
88 REGIONALIZATION 7 311 7.711e-07 4.077e-05
89 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 197 9.046e-07 4.729e-05
90 TUBE MORPHOGENESIS 7 323 9.933e-07 5.135e-05
91 EYE DEVELOPMENT 7 326 1.057e-06 5.402e-05
92 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 1.284e-06 6.426e-05
93 CELL PROLIFERATION 9 672 1.277e-06 6.426e-05
94 HEART MORPHOGENESIS 6 212 1.387e-06 6.868e-05
95 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 3 14 1.613e-06 7.659e-05
96 CELLULAR COMPONENT MORPHOGENESIS 10 900 1.585e-06 7.659e-05
97 REGULATION OF CELLULAR RESPONSE TO STRESS 9 691 1.609e-06 7.659e-05
98 CONVERGENT EXTENSION 3 14 1.613e-06 7.659e-05
99 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 1.639e-06 7.701e-05
100 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 1152 1.849e-06 8.603e-05
101 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 4 53 1.921e-06 8.823e-05
102 FOREBRAIN DEVELOPMENT 7 357 1.934e-06 8.823e-05
103 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 6 228 2.116e-06 9.561e-05
104 POSITIVE REGULATION OF GENE EXPRESSION 13 1733 2.424e-06 0.0001084
105 TUBE FORMATION 5 129 2.473e-06 0.0001087
106 PARAXIAL MESODERM DEVELOPMENT 3 16 2.476e-06 0.0001087
107 MESENCHYMAL CELL DIFFERENTIATION 5 134 2.982e-06 0.0001297
108 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 135 3.093e-06 0.0001332
109 SOMITOGENESIS 4 62 3.621e-06 0.0001532
110 POST ANAL TAIL MORPHOGENESIS 3 18 3.599e-06 0.0001532
111 REGULATION OF TRANSPORT 13 1804 3.798e-06 0.0001592
112 POSITIVE REGULATION OF CATALYTIC ACTIVITY 12 1518 3.971e-06 0.000165
113 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 19 4.269e-06 0.0001743
114 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 4.269e-06 0.0001743
115 EMBRYONIC ORGAN DEVELOPMENT 7 406 4.521e-06 0.0001829
116 REPRODUCTIVE SYSTEM DEVELOPMENT 7 408 4.669e-06 0.0001841
117 MESODERM MORPHOGENESIS 4 66 4.655e-06 0.0001841
118 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 4.655e-06 0.0001841
119 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 13 1848 4.965e-06 0.0001941
120 REGULATION OF MUSCLE CELL DIFFERENTIATION 5 152 5.529e-06 0.000214
121 SYNAPSE ASSEMBLY 4 69 5.564e-06 0.000214
122 NEURAL PRECURSOR CELL PROLIFERATION 4 70 5.894e-06 0.0002248
123 GASTRULATION 5 155 6.082e-06 0.0002301
124 NEGATIVE REGULATION OF CELL DIFFERENTIATION 8 609 6.363e-06 0.0002388
125 EMBRYONIC ORGAN MORPHOGENESIS 6 279 6.764e-06 0.0002518
126 REGULATION OF CELL DEVELOPMENT 9 836 7.625e-06 0.0002816
127 REGULATION OF DEVELOPMENTAL GROWTH 6 289 8.271e-06 0.000303
128 REGULATION OF BMP SIGNALING PATHWAY 4 77 8.627e-06 0.0003136
129 NEGATIVE REGULATION OF CELL DEATH 9 872 1.071e-05 0.0003862
130 HEART DEVELOPMENT 7 466 1.112e-05 0.0003979
131 REGULATION OF MAPK CASCADE 8 660 1.144e-05 0.0004033
132 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 3 26 1.136e-05 0.0004033
133 POSITIVE REGULATION OF MAPK CASCADE 7 470 1.175e-05 0.0004111
134 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 4 84 1.22e-05 0.0004235
135 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 85 1.278e-05 0.0004374
136 REGULATION OF CATENIN IMPORT INTO NUCLEUS 3 27 1.277e-05 0.0004374
137 POSITIVE REGULATION OF KINASE ACTIVITY 7 482 1.383e-05 0.0004699
138 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 1.428e-05 0.0004816
139 CELL DEVELOPMENT 11 1426 1.44e-05 0.000482
140 REGULATION OF STEM CELL PROLIFERATION 4 88 1.467e-05 0.0004876
141 SEGMENTATION 4 89 1.534e-05 0.0005063
142 AXIS SPECIFICATION 4 90 1.604e-05 0.0005255
143 DORSAL VENTRAL PATTERN FORMATION 4 91 1.675e-05 0.0005451
144 POSITIVE REGULATION OF CELL CYCLE 6 332 1.817e-05 0.0005872
145 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 337 1.977e-05 0.0006344
146 REGULATION OF ENDOCYTOSIS 5 199 2.041e-05 0.0006504
147 REGULATION OF CELL CYCLE 9 949 2.104e-05 0.0006661
148 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 12 1805 2.339e-05 0.0007352
149 EMBRYONIC AXIS SPECIFICATION 3 33 2.365e-05 0.0007386
150 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 11 1517 2.575e-05 0.0007984
151 REGULATION OF MESENCHYMAL CELL PROLIFERATION 3 34 2.591e-05 0.0007984
152 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 102 2.629e-05 0.0008047
153 REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 103 2.732e-05 0.0008254
154 REGULATION OF MUSCLE ORGAN DEVELOPMENT 4 103 2.732e-05 0.0008254
155 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 9 983 2.78e-05 0.0008347
156 CARDIAC CHAMBER MORPHOGENESIS 4 104 2.838e-05 0.000841
157 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 4 104 2.838e-05 0.000841
158 RESPONSE TO ALCOHOL 6 362 2.956e-05 0.0008705
159 REGULATION OF FAT CELL DIFFERENTIATION 4 106 3.058e-05 0.000895
160 REGULATION OF RECEPTOR INTERNALIZATION 3 37 3.353e-05 0.000975
161 REGULATION OF NEURON DIFFERENTIATION 7 554 3.383e-05 0.0009776
162 REGULATION OF CELLULAR COMPONENT MOVEMENT 8 771 3.502e-05 0.001006
163 FORMATION OF PRIMARY GERM LAYER 4 110 3.537e-05 0.00101
164 MESENCHYME MORPHOGENESIS 3 38 3.636e-05 0.001032
165 REGULATION OF KINASE ACTIVITY 8 776 3.667e-05 0.001034
166 REGULATION OF SYNAPSE ORGANIZATION 4 113 3.931e-05 0.001102
167 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 5 232 4.254e-05 0.001185
168 MAMMARY GLAND DEVELOPMENT 4 117 4.504e-05 0.001248
169 NEGATIVE REGULATION OF GROWTH 5 236 4.614e-05 0.00127
170 MESODERM DEVELOPMENT 4 118 4.657e-05 0.001275
171 GLAND DEVELOPMENT 6 395 4.811e-05 0.001309
172 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 4 121 5.137e-05 0.00139
173 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 3 43 5.288e-05 0.001422
174 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 7 602 5.731e-05 0.001532
175 POSITIVE REGULATION OF CELL DEATH 7 605 5.913e-05 0.001572
176 OSTEOBLAST DIFFERENTIATION 4 126 6.016e-05 0.001591
177 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 7 616 6.624e-05 0.001741
178 DIGESTIVE TRACT MORPHOGENESIS 3 48 7.368e-05 0.001926
179 NEGATIVE REGULATION OF LOCOMOTION 5 263 7.71e-05 0.002004
180 REGULATION OF GROWTH 7 633 7.86e-05 0.002019
181 MUSCLE STRUCTURE DEVELOPMENT 6 432 7.899e-05 0.002019
182 CARDIAC SEPTUM MORPHOGENESIS 3 49 7.839e-05 0.002019
183 SEX DIFFERENTIATION 5 266 8.134e-05 0.002068
184 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 8.416e-05 0.002128
185 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 8.627e-05 0.00217
186 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 8.848e-05 0.002214
187 RESPONSE TO HORMONE 8 893 9.866e-05 0.002455
188 MAMMARY GLAND EPITHELIUM DEVELOPMENT 3 53 9.922e-05 0.002456
189 CARDIAC CHAMBER DEVELOPMENT 4 144 0.0001011 0.002475
190 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 4 144 0.0001011 0.002475
191 RESPONSE TO ENDOGENOUS STIMULUS 10 1450 0.0001017 0.002479
192 SYNAPSE ORGANIZATION 4 145 0.0001038 0.002515
193 SKELETAL SYSTEM DEVELOPMENT 6 455 0.0001051 0.00252
194 VENTRICULAR SEPTUM DEVELOPMENT 3 54 0.0001049 0.00252
195 RESPONSE TO ESTRADIOL 4 146 0.0001066 0.002543
196 POSITIVE REGULATION OF HYDROLASE ACTIVITY 8 905 0.0001083 0.00257
197 REGULATION OF RESPONSE TO STRESS 10 1468 0.0001128 0.00265
198 MALE SEX DIFFERENTIATION 4 148 0.0001123 0.00265
199 REGULATION OF VESICLE MEDIATED TRANSPORT 6 462 0.0001142 0.002671
200 REGULATION OF GTPASE ACTIVITY 7 673 0.0001153 0.002682
201 OUTFLOW TRACT MORPHOGENESIS 3 56 0.000117 0.002708
202 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 289 0.0001201 0.002767
203 VASCULATURE DEVELOPMENT 6 469 0.000124 0.002842
204 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 470 0.0001255 0.002862
205 POSITIVE REGULATION OF CELL DEVELOPMENT 6 472 0.0001284 0.002914
206 NEGATIVE REGULATION OF GENE EXPRESSION 10 1493 0.0001298 0.002921
207 EMBRYONIC PATTERN SPECIFICATION 3 58 0.0001299 0.002921
208 STEM CELL PROLIFERATION 3 60 0.0001438 0.003216
209 PROTEIN PHOSPHORYLATION 8 944 0.0001451 0.003229
210 REGULATION OF TRANSFERASE ACTIVITY 8 946 0.0001472 0.003261
211 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.000151 0.00333
212 POSITIVE REGULATION OF CELL FATE COMMITMENT 2 11 0.0001528 0.003338
213 REGULATION OF CELL CELL ADHESION MEDIATED BY CADHERIN 2 11 0.0001528 0.003338
214 REGULATION OF CARTILAGE DEVELOPMENT 3 63 0.0001662 0.003599
215 RESPONSE TO CYTOKINE 7 714 0.0001663 0.003599
216 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 2 12 0.0001832 0.00391
217 EMBRYONIC CAMERA TYPE EYE FORMATION 2 12 0.0001832 0.00391
218 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 2 12 0.0001832 0.00391
219 APPENDAGE DEVELOPMENT 4 169 0.0001872 0.00396
220 LIMB DEVELOPMENT 4 169 0.0001872 0.00396
221 NEGATIVE REGULATION OF CELL GROWTH 4 170 0.0001915 0.004014
222 FOREBRAIN GENERATION OF NEURONS 3 66 0.0001909 0.004014
223 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 3 67 0.0001996 0.004147
224 INTRACELLULAR SIGNAL TRANSDUCTION 10 1572 0.0001988 0.004147
225 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0002086 0.004314
226 HEMATOPOIETIC STEM CELL PROLIFERATION 2 13 0.0002162 0.004433
227 REGULATION OF CELL FATE SPECIFICATION 2 13 0.0002162 0.004433
228 MUSCLE ORGAN MORPHOGENESIS 3 70 0.0002273 0.004639
229 DEVELOPMENTAL GROWTH 5 333 0.0002324 0.004721
230 POSITIVE REGULATION OF MEIOTIC CELL CYCLE 2 14 0.000252 0.005011
231 RESPONSE TO KETONE 4 182 0.0002486 0.005011
232 CELL MIGRATION INVOLVED IN GASTRULATION 2 14 0.000252 0.005011
233 REGULATION OF PROTEIN KINASE C SIGNALING 2 14 0.000252 0.005011
234 CELLULAR RESPONSE TO VITAMIN D 2 14 0.000252 0.005011
235 REGULATION OF CELLULAR COMPONENT BIOGENESIS 7 767 0.0002581 0.005088
236 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 73 0.0002574 0.005088
237 REGULATION OF HYDROLASE ACTIVITY 9 1327 0.0002795 0.005488
238 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 4 188 0.0002813 0.005499
239 REGULATION OF MESODERM DEVELOPMENT 2 15 0.0002905 0.005655
240 REGULATION OF CELL MORPHOGENESIS 6 552 0.0002996 0.005808
241 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 10 1656 0.000304 0.005869
242 REGULATION OF RECEPTOR MEDIATED ENDOCYTOSIS 3 78 0.000313 0.006018
243 ANTERIOR POSTERIOR PATTERN SPECIFICATION 4 194 0.0003169 0.006069
244 REGULATION OF SYNAPSE ASSEMBLY 3 79 0.000325 0.006197
245 ORGAN INDUCTION 2 16 0.0003316 0.006273
246 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 2 16 0.0003316 0.006273
247 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.000336 0.006329
248 REGULATION OF FIBROBLAST PROLIFERATION 3 81 0.0003498 0.006537
249 REGULATION OF JUN KINASE ACTIVITY 3 81 0.0003498 0.006537
250 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 2 17 0.0003754 0.006932
251 ESTABLISHMENT OF TISSUE POLARITY 2 17 0.0003754 0.006932
252 NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 2 17 0.0003754 0.006932
253 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 84 0.0003893 0.00716
254 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0004031 0.007383
255 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 207 0.0004053 0.007383
256 POSITIVE REGULATION OF CELL ADHESION 5 376 0.0004062 0.007383
257 NOTOCHORD DEVELOPMENT 2 18 0.0004219 0.007609
258 UTERUS DEVELOPMENT 2 18 0.0004219 0.007609
259 SKIN DEVELOPMENT 4 211 0.0004357 0.007827
260 LOCOMOTION 8 1114 0.0004476 0.00801
261 EPITHELIAL CELL PROLIFERATION 3 89 0.0004613 0.008224
262 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 4 216 0.0004759 0.008452
263 RESPONSE TO ESTROGEN 4 218 0.0004927 0.008717
264 REGULATION OF PROTEIN CATABOLIC PROCESS 5 393 0.000497 0.008759
265 INNER EAR MORPHOGENESIS 3 92 0.0005083 0.008926
266 RESPONSE TO NITROGEN COMPOUND 7 859 0.000512 0.008957
267 DORSAL VENTRAL AXIS SPECIFICATION 2 20 0.0005228 0.009112
268 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 10 1784 0.0005528 0.009597
269 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 5 406 0.0005761 0.009965
NumGOOverlapSizeP ValueAdj. P Value
1 FRIZZLED BINDING 10 36 1.151e-20 1.069e-17
2 WNT PROTEIN BINDING 6 31 1.082e-11 3.445e-09
3 G PROTEIN COUPLED RECEPTOR BINDING 10 259 1.113e-11 3.445e-09
4 WNT ACTIVATED RECEPTOR ACTIVITY 5 22 2.693e-10 6.255e-08
5 RECEPTOR AGONIST ACTIVITY 4 16 1.248e-08 1.933e-06
6 RECEPTOR REGULATOR ACTIVITY 5 45 1.215e-08 1.933e-06
7 RECEPTOR ACTIVATOR ACTIVITY 4 32 2.42e-07 3.211e-05
8 SIGNAL TRANSDUCER ACTIVITY 13 1731 2.392e-06 0.0002778
9 RECEPTOR BINDING 12 1476 2.964e-06 0.0003059
10 PDZ DOMAIN BINDING 4 90 1.604e-05 0.00149
11 MOLECULAR FUNCTION REGULATOR 10 1353 5.678e-05 0.004795
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEINACEOUS EXTRACELLULAR MATRIX 9 356 5.746e-09 3.355e-06
2 EXTRACELLULAR MATRIX 9 426 2.714e-08 7.925e-06
3 EXTRACELLULAR SPACE 12 1376 1.418e-06 0.000276
4 ENDOCYTIC VESICLE MEMBRANE 5 152 5.529e-06 0.0007522
5 SYNAPSE PART 8 610 6.44e-06 0.0007522
6 NEURON PART 10 1265 3.198e-05 0.002334
7 SYNAPSE 8 754 2.987e-05 0.002334
8 CELL SURFACE 8 757 3.073e-05 0.002334
9 ENDOCYTIC VESICLE 5 256 6.787e-05 0.004404
10 PRESYNAPSE 5 283 0.0001089 0.006357
11 WNT SIGNALOSOME 2 11 0.0001528 0.008113

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 34 151 1.301e-74 2.303e-72
2 hsa04916_Melanogenesis 17 101 4.765e-31 4.217e-29
3 hsa04340_Hedgehog_signaling_pathway 8 56 3.848e-14 2.27e-12
4 hsa04720_Long.term_potentiation 6 70 1.838e-09 8.135e-08
5 hsa04971_Gastric_acid_secretion 6 74 2.585e-09 9.15e-08
6 hsa04912_GnRH_signaling_pathway 6 101 1.712e-08 5.05e-07
7 hsa04012_ErbB_signaling_pathway 5 87 3.493e-07 8.833e-06
8 hsa04020_Calcium_signaling_pathway 6 177 4.832e-07 1.069e-05
9 hsa04510_Focal_adhesion 6 200 9.88e-07 1.943e-05
10 hsa04730_Long.term_depression 4 70 5.894e-06 0.0001043
11 hsa04370_VEGF_signaling_pathway 4 76 8.188e-06 0.0001318
12 hsa04070_Phosphatidylinositol_signaling_system 4 78 9.082e-06 0.000134
13 hsa04970_Salivary_secretion 4 89 1.534e-05 0.0002027
14 hsa04540_Gap_junction 4 90 1.604e-05 0.0002027
15 hsa04972_Pancreatic_secretion 4 101 2.529e-05 0.0002984
16 hsa04270_Vascular_smooth_muscle_contraction 4 116 4.356e-05 0.0004818
17 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 136 8.097e-05 0.0008286
18 hsa04010_MAPK_signaling_pathway 5 268 8.426e-05 0.0008286
19 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.000325 0.003027
20 hsa04722_Neurotrophin_signaling_pathway 3 127 0.001296 0.01117
21 hsa04380_Osteoclast_differentiation 3 128 0.001325 0.01117
22 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.002314 0.01862
23 hsa00562_Inositol_phosphate_metabolism 2 57 0.004222 0.03249
24 hsa04115_p53_signaling_pathway 2 69 0.006128 0.04519
25 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.007203 0.051
26 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.01135 0.07724
27 hsa04114_Oocyte_meiosis 2 114 0.01604 0.1052
28 hsa04670_Leukocyte_transendothelial_migration 2 117 0.01685 0.1065
29 hsa04110_Cell_cycle 2 128 0.01995 0.1212
30 hsa04360_Axon_guidance 2 130 0.02053 0.1212
31 hsa04530_Tight_junction 2 133 0.02143 0.1224
32 hsa04630_Jak.STAT_signaling_pathway 2 155 0.02847 0.1575
33 hsa04062_Chemokine_signaling_pathway 2 189 0.04089 0.2193
34 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.05111 0.2661
35 hsa04740_Olfactory_transduction 2 388 0.1406 0.6223

Quest ID: f55c4e7574f2b1660994640da9ec5c11