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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-484 ACTA2 -0.97 0 1.38 0 miRNAWalker2 validate -0.49 0 NA
2 hsa-miR-484 ADAM10 -0.97 0 0.28 0.07197 miRNAWalker2 validate -0.38 0 NA
3 hsa-miR-484 ADRA1A -0.97 0 2.36 0 miRNAWalker2 validate -0.98 0 NA
4 hsa-miR-484 AEBP2 -0.97 0 0.32 0 miRNAWalker2 validate -0.13 0 NA
5 hsa-miR-484 AGL -0.97 0 0.51 0 miRNAWalker2 validate -0.27 0 NA
6 hsa-miR-484 AHDC1 -0.97 0 0.63 0 miRNAWalker2 validate -0.12 7.0E-5 NA
7 hsa-miR-484 AKAP13 -0.97 0 0.24 0.00396 miRNAWalker2 validate -0.11 0.00011 NA
8 hsa-miR-484 AKAP7 -0.97 0 0.66 1.0E-5 miRNAWalker2 validate -0.38 0 NA
9 hsa-miR-484 AMOTL1 -0.97 0 0.38 0.00203 miRNAWalker2 validate -0.21 0 NA
10 hsa-miR-484 ANAPC1 -0.97 0 0.1 0.28593 miRNAWalker2 validate -0.17 0 NA
11 hsa-miR-484 AP1G1 -0.97 0 0.1 0.21459 miRNAWalker2 validate -0.13 0 NA
12 hsa-miR-484 APP -0.97 0 0.48 2.0E-5 miRNAWalker2 validate -0.18 2.0E-5 NA
13 hsa-miR-484 ARFGEF2 -0.97 0 0.32 0.00076 miRNAWalker2 validate -0.21 0 NA
14 hsa-miR-484 ATL2 -0.97 0 0.4 0 miRNAWalker2 validate -0.15 0 NA
15 hsa-miR-484 ATP1A1 -0.97 0 0.26 0.00124 miRNAWalker2 validate -0.11 0.00033 NA
16 hsa-miR-484 ATP2A2 -0.97 0 0.33 5.0E-5 miRNAWalker2 validate -0.17 0 NA
17 hsa-miR-484 B4GALT1 -0.97 0 0.33 3.0E-5 miRNAWalker2 validate -0.2 0 NA
18 hsa-miR-484 BACE2 -0.97 0 -0.38 0.00565 miRNAWalker2 validate -0.17 0.00087 NA
19 hsa-miR-484 BBX -0.97 0 0.86 0 miRNAWalker2 validate -0.26 0 NA
20 hsa-miR-484 CAMK2D -0.97 0 0.51 0 miRNAWalker2 validate -0.1 0.00133 NA
21 hsa-miR-484 CBX6 -0.97 0 0.85 0 miRNAWalker2 validate -0.4 0 NA
22 hsa-miR-484 CCDC136 -0.97 0 0.86 0 miRNAWalker2 validate -0.29 0 NA
23 hsa-miR-484 CCNT2 -0.97 0 0.22 0.01103 miRNAWalker2 validate -0.1 0.00104 NA
24 hsa-miR-484 CDCA7L -0.97 0 0.54 0.0004 miRNAWalker2 validate -0.21 0.00011 NA
25 hsa-miR-484 CDX2 -0.97 0 -0.26 0.4968 miRNAWalker2 validate -0.37 0.00726 NA
26 hsa-miR-484 CECR2 -0.97 0 -1.22 0 miRNAWalker2 validate -0.24 0.00172 NA
27 hsa-miR-484 CRTAP -0.97 0 0.51 0 miRNAWalker2 validate -0.15 0 NA
28 hsa-miR-484 DDI2 -0.97 0 0.4 0.09923 miRNAWalker2 validate -0.43 0 NA
29 hsa-miR-484 DGKA -0.97 0 0.34 0.00372 miRNAWalker2 validate -0.11 0.00995 NA
30 hsa-miR-484 DHCR24 -0.97 0 -0.72 0 miRNAWalker2 validate -0.14 0.00692 NA
31 hsa-miR-484 DST -0.97 0 1.08 0 miRNAWalker2 validate -0.46 0 NA
32 hsa-miR-484 DSTN -0.97 0 0.63 0 miRNAWalker2 validate -0.2 0 NA
33 hsa-miR-484 EDA2R -0.97 0 1.15 0 miRNAWalker2 validate -0.54 0 NA
34 hsa-miR-484 EFNB3 -0.97 0 0.96 0 miRNAWalker2 validate -0.42 0 NA
35 hsa-miR-484 EIF4G2 -0.97 0 0.28 0 miRNAWalker2 validate -0.11 0 NA
36 hsa-miR-484 EIF5B -0.97 0 0.25 0.00143 miRNAWalker2 validate -0.11 0.00011 NA
37 hsa-miR-484 EXOC5 -0.97 0 0.13 0.04464 miRNAWalker2 validate -0.11 1.0E-5 NA
38 hsa-miR-484 EXOC6B -0.97 0 0.82 1.0E-5 miRNAWalker2 validate -0.39 0 NA
39 hsa-miR-484 FAM129A -0.97 0 0.42 0.00201 miRNAWalker2 validate -0.27 0 NA
40 hsa-miR-484 FAM46A -0.97 0 1.02 0 miRNAWalker2 validate -0.15 0.00671 NA
41 hsa-miR-484 FLNA -0.97 0 1.5 0 miRNAWalker2 validate -0.6 0 NA
42 hsa-miR-484 FUT11 -0.97 0 0.18 0.07723 miRNAWalker2 validate -0.21 0 NA
43 hsa-miR-484 FYCO1 -0.97 0 0.54 0 miRNAWalker2 validate -0.26 0 NA
44 hsa-miR-484 G3BP2 -0.97 0 -0.14 0.06557 miRNAWalker2 validate -0.15 0 NA
45 hsa-miR-484 GFOD1 -0.97 0 0.69 0 miRNAWalker2 validate -0.28 0 NA
46 hsa-miR-484 GLCE -0.97 0 0.69 0 miRNAWalker2 validate -0.24 0 NA
47 hsa-miR-484 GLUL -0.97 0 0.58 0 miRNAWalker2 validate -0.17 0 NA
48 hsa-miR-484 GTF2H3 -0.97 0 0.32 0.00435 miRNAWalker2 validate -0.24 0 NA
49 hsa-miR-484 GTF2I -0.97 0 0.3 0.03125 miRNAWalker2 validate -0.26 0 NA
50 hsa-miR-484 GTF3C3 -0.97 0 0.17 0.03159 miRNAWalker2 validate -0.14 0 NA
51 hsa-miR-484 HIPK1 -0.97 0 0.28 0.00021 miRNAWalker2 validate -0.14 0 NA
52 hsa-miR-484 HIVEP2 -0.97 0 0.33 0.00366 miRNAWalker2 validate -0.14 0.00069 NA
53 hsa-miR-484 IFNAR2 -0.97 0 0.1 0.14566 miRNAWalker2 validate -0.11 1.0E-5 NA
54 hsa-miR-484 IGF1R -0.97 0 -0.09 0.4913 miRNAWalker2 validate -0.19 6.0E-5 NA
55 hsa-miR-484 ISM2 -0.97 0 1.05 3.0E-5 miRNAWalker2 validate -0.77 0 NA
56 hsa-miR-484 ITGA5 -0.97 0 1 0 miRNAWalker2 validate -0.26 0 NA
57 hsa-miR-484 ITGA9 -0.97 0 1.57 0 miRNAWalker2 validate -0.72 0 NA
58 hsa-miR-484 KIAA1109 -0.97 0 0.27 0.00786 miRNAWalker2 validate -0.18 0 NA
59 hsa-miR-484 KREMEN1 -0.97 0 0.44 1.0E-5 miRNAWalker2 validate -0.14 0.0001 NA
60 hsa-miR-484 LAMB2 -0.97 0 0.43 2.0E-5 miRNAWalker2 validate -0.19 0 NA
61 hsa-miR-484 M6PR -0.97 0 0.36 0 miRNAWalker2 validate -0.13 0 NA
62 hsa-miR-484 MDN1 -0.97 0 0.3 0.07352 miRNAWalker2 validate -0.31 0 NA
63 hsa-miR-484 MED12L -0.97 0 0.18 0.51594 miRNAWalker2 validate -0.39 0.00013 NA
64 hsa-miR-484 MEIS1 -0.97 0 1.33 0 miRNAWalker2 validate -0.47 0 NA
65 hsa-miR-484 MFN2 -0.97 0 0.54 0 miRNAWalker2 validate -0.14 0 NA
66 hsa-miR-484 MPP2 -0.97 0 1.71 0 miRNAWalker2 validate -0.6 0 NA
67 hsa-miR-484 MTR -0.97 0 0.45 0 miRNAWalker2 validate -0.13 0 NA
68 hsa-miR-484 MYO5A -0.97 0 -0.14 0.13635 miRNAWalker2 validate -0.12 0.00021 NA
69 hsa-miR-484 NCOA4 -0.97 0 0.22 0.00695 miRNAWalker2 validate -0.27 0 NA
70 hsa-miR-484 NCOR1 -0.97 0 0.37 0.0001 miRNAWalker2 validate -0.14 5.0E-5 NA
71 hsa-miR-484 NCS1 -0.97 0 1.1 0 miRNAWalker2 validate -0.26 0 NA
72 hsa-miR-484 NEO1 -0.97 0 0.04 0.67866 miRNAWalker2 validate -0.17 0 NA
73 hsa-miR-484 NHLRC2 -0.97 0 0.36 0.01904 miRNAWalker2 validate -0.3 0 NA
74 hsa-miR-484 NMD3 -0.97 0 0.02 0.74644 miRNAWalker2 validate -0.13 0 NA
75 hsa-miR-484 NUS1 -0.97 0 0.09 0.37927 miRNAWalker2 validate -0.11 0.00252 NA
76 hsa-miR-484 NYNRIN -0.97 0 2.05 0 miRNAWalker2 validate -0.65 0 NA
77 hsa-miR-484 PEG10 -0.97 0 1.83 0 miRNAWalker2 validate -0.34 0.00011 NA
78 hsa-miR-484 PER1 -0.97 0 0.78 0 miRNAWalker2 validate -0.19 0.00037 NA
79 hsa-miR-484 PPARGC1B -0.97 0 1.55 0 miRNAWalker2 validate -0.47 0 NA
80 hsa-miR-484 PTGS1 -0.97 0 2.1 0 miRNAWalker2 validate -0.64 0 NA
81 hsa-miR-484 PURA -0.97 0 0.38 0 miRNAWalker2 validate -0.15 0 NA
82 hsa-miR-484 PYGB -0.97 0 0.31 9.0E-5 miRNAWalker2 validate -0.15 0 NA
83 hsa-miR-484 RBMS2 -0.97 0 0.61 0 miRNAWalker2 validate -0.2 0 NA
84 hsa-miR-484 RC3H2 -0.97 0 0.26 0.0424 miRNAWalker2 validate -0.18 0.00013 NA
85 hsa-miR-484 RFWD3 -0.97 0 0.19 0.0082 miRNAWalker2 validate -0.11 4.0E-5 NA
86 hsa-miR-484 RGP1 -0.97 0 0.39 0.0058 miRNAWalker2 validate -0.23 1.0E-5 NA
87 hsa-miR-484 RNF111 -0.97 0 0.35 1.0E-5 miRNAWalker2 validate -0.2 0 NA
88 hsa-miR-484 RNMT -0.97 0 0.12 0.03296 miRNAWalker2 validate -0.1 0 NA
89 hsa-miR-484 RRAGD -0.97 0 0 0.97833 miRNAWalker2 validate -0.11 0.01152 NA
90 hsa-miR-484 RUNX2 -0.97 0 0.69 0 miRNAWalker2 validate -0.27 0 NA
91 hsa-miR-484 SALL2 -0.97 0 0.11 0.28412 miRNAWalker2 validate -0.12 0.00134 NA
92 hsa-miR-484 SCD -0.97 0 -0.55 0.00644 miRNAWalker2 validate -0.17 0.02407 NA
93 hsa-miR-484 SETD7 -0.97 0 -0.1 0.25996 miRNAWalker2 validate -0.16 0 NA
94 hsa-miR-484 SLC11A2 -0.97 0 -0.12 0.05964 miRNAWalker2 validate -0.11 1.0E-5 NA
95 hsa-miR-484 SLC38A1 -0.97 0 0.58 0 miRNAWalker2 validate -0.18 0 NA
96 hsa-miR-484 SLK -0.97 0 0.3 0.0005 miRNAWalker2 validate -0.16 0 NA
97 hsa-miR-484 SORD -0.97 0 -0.14 0.28645 miRNAWalker2 validate -0.16 0.00155 NA
98 hsa-miR-484 SP3 -0.97 0 0.26 0.00041 miRNAWalker2 validate -0.14 0 NA
99 hsa-miR-484 SPAG9 -0.97 0 0.33 0 miRNAWalker2 validate -0.14 0 NA
100 hsa-miR-484 SRF -0.97 0 0.58 0 miRNAWalker2 validate -0.13 0.00108 NA
101 hsa-miR-484 ST3GAL2 -0.97 0 0.45 0 miRNAWalker2 validate -0.1 0.00127 NA
102 hsa-miR-484 STRN -0.97 0 0.3 0.11919 miRNAWalker2 validate -0.33 0 NA
103 hsa-miR-484 SYNE2 -0.97 0 0.19 0.05271 miRNAWalker2 validate -0.2 0 NA
104 hsa-miR-484 TBC1D2B -0.97 0 0.39 0 miRNAWalker2 validate -0.12 0 NA
105 hsa-miR-484 TLN1 -0.97 0 0.74 0 miRNAWalker2 validate -0.24 0 NA
106 hsa-miR-484 TMEM131 -0.97 0 -0.05 0.44688 miRNAWalker2 validate -0.12 0 NA
107 hsa-miR-484 TMEM98 -0.97 0 -0.44 0 miRNAWalker2 validate -0.12 0.00021 NA
108 hsa-miR-484 TMF1 -0.97 0 0.2 0.01228 miRNAWalker2 validate -0.1 0.00034 NA
109 hsa-miR-484 TMOD2 -0.97 0 0.89 0 miRNAWalker2 validate -0.15 0.0002 NA
110 hsa-miR-484 TNFAIP8L1 -0.97 0 0.32 0.0042 miRNAWalker2 validate -0.15 0.00016 NA
111 hsa-miR-484 TRIM44 -0.97 0 0.22 0.08578 miRNAWalker2 validate -0.24 0 NA
112 hsa-miR-484 TRIP6 -0.97 0 1.1 0 miRNAWalker2 validate -0.21 1.0E-5 NA
113 hsa-miR-484 TSC22D3 -0.97 0 0.65 0 miRNAWalker2 validate -0.21 0 NA
114 hsa-miR-484 TSPAN6 -0.97 0 -0.04 0.6185 miRNAWalker2 validate -0.15 0 NA
115 hsa-miR-484 TUBGCP4 -0.97 0 0.13 0.12862 miRNAWalker2 validate -0.13 3.0E-5 NA
116 hsa-miR-484 UTP14C -0.97 0 0.39 4.0E-5 miRNAWalker2 validate -0.25 0 NA
117 hsa-miR-484 UTRN -0.97 0 -0.33 0.02056 miRNAWalker2 validate -0.11 0.03261 NA
118 hsa-miR-484 WEE1 -0.97 0 0.4 0.00059 miRNAWalker2 validate -0.14 0.00138 NA
119 hsa-miR-484 ZFX -0.97 0 0.45 5.0E-5 miRNAWalker2 validate -0.23 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION ASSEMBLY 8 129 1.037e-06 0.004824
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 29 1737 2.496e-07 0.0002319
2 KINASE BINDING 15 606 3.164e-06 0.00147
3 MACROMOLECULAR COMPLEX BINDING 22 1399 2.365e-05 0.007323
4 INTEGRIN BINDING 6 105 3.893e-05 0.009042
NumGOOverlapSizeP ValueAdj. P Value
1 FILOPODIUM 6 94 2.077e-05 0.006065
2 ORGANELLE SUBCOMPARTMENT 10 311 1.706e-05 0.006065

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 6 199 0.001231 0.06399
2 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.002928 0.07612
3 Oocyte_meiosis_hsa04114 4 124 0.006461 0.112
4 ECM_receptor_interaction_hsa04512 3 82 0.01293 0.1682
5 Necroptosis_hsa04217 4 164 0.01671 0.1738
6 Ferroptosis_hsa04216 2 40 0.02363 0.2048
7 AMPK_signaling_pathway_hsa04152 3 121 0.03564 0.2414
8 Lysosome_hsa04142 3 123 0.03714 0.2414
9 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.05934 0.3429
10 Calcium_signaling_pathway_hsa04020 3 182 0.09478 0.4929
11 cAMP_signaling_pathway_hsa04024 3 198 0.1144 0.5179
12 HIF_1_signaling_pathway_hsa04066 2 100 0.1195 0.5179
13 Cell_cycle_hsa04110 2 124 0.1685 0.6264
14 Autophagy_animal_hsa04140 2 128 0.1769 0.6264
15 FoxO_signaling_pathway_hsa04068 2 132 0.1855 0.6264
16 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.2005 0.6264
17 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.2136 0.6264
18 mTOR_signaling_pathway_hsa04150 2 151 0.2267 0.6264
19 Phagosome_hsa04145 2 152 0.2289 0.6264
20 MAPK_signaling_pathway_hsa04010 3 295 0.2567 0.6675
21 Rap1_signaling_pathway_hsa04015 2 206 0.3473 0.7618
22 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.3516 0.7618
23 Endocytosis_hsa04144 2 244 0.4273 0.8546
24 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.4791 0.8897

Quest ID: f68ad66243c2cf0ee35d50aadae38dc0