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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-5p ADAM10 0.84 4.0E-5 0.67 0.00766 MirTarget; PITA; miRanda -0.12 0.04176 NA
2 hsa-miR-155-5p ADAM10 1.2 0.00086 0.67 0.00766 miRNAWalker2 validate -0.11 0.00135 NA
3 hsa-miR-199a-3p ADAM10 0.64 0.03803 0.67 0.00766 MirTarget -0.1 0.01088 NA
4 hsa-miR-199b-3p ADAM10 0.64 0.03717 0.67 0.00766 MirTarget -0.1 0.01105 NA
5 hsa-miR-374b-5p ADAM10 0.07 0.72267 0.67 0.00766 MirTarget; mirMAP -0.2 0.00316 NA
6 hsa-miR-655-3p ADAM10 0.49 0.13701 0.67 0.00766 MirTarget -0.12 0.0015 27259866 MicroRNA 655 3p functions as a tumor suppressor by regulating ADAM10 and β catenin pathway in Hepatocellular Carcinoma; MiR-655-3p might functions as a tumor suppressor by directly targeting ADAM10 and indirectly regulating β-catenin pathway in the development of progression of HCC
7 hsa-miR-92b-3p ADAM10 1.2 0 0.67 0.00766 MirTarget -0.11 0.0222 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 31 1929 3.37e-16 1.568e-12
2 POSITIVE REGULATION OF CELL COMMUNICATION 27 1532 7.367e-15 1.714e-11
3 REGULATION OF CELL DEATH 26 1472 2.741e-14 4.251e-11
4 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 1656 3.517e-12 4.091e-09
5 NEGATIVE REGULATION OF CELL DEATH 18 872 6.093e-11 5.091e-08
6 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 876 6.565e-11 5.091e-08
7 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 19 1087 2.678e-10 1.558e-07
8 REGULATION OF PROTEOLYSIS 16 711 2.512e-10 1.558e-07
9 NEUROGENESIS 21 1402 3.996e-10 2.066e-07
10 CELL DEVELOPMENT 21 1426 5.449e-10 2.536e-07
11 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 18 1036 9.841e-10 3.522e-07
12 POSITIVE REGULATION OF MOLECULAR FUNCTION 23 1791 9.055e-10 3.522e-07
13 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 18 1036 9.841e-10 3.522e-07
14 IMMUNE SYSTEM PROCESS 24 1984 1.122e-09 3.73e-07
15 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 22 1672 1.542e-09 4.784e-07
16 NOTCH SIGNALING PATHWAY 8 114 1.99e-09 5.788e-07
17 POSITIVE REGULATION OF CELL DEATH 14 605 2.809e-09 7.69e-07
18 LOCOMOTION 18 1114 3.11e-09 8.04e-07
19 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 983 3.447e-09 8.442e-07
20 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 513 3.816e-09 8.877e-07
21 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 18 1152 5.268e-09 1.167e-06
22 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 17 1021 6.081e-09 1.286e-06
23 REGULATION OF CELLULAR COMPONENT MOVEMENT 15 771 7.277e-09 1.472e-06
24 NEGATIVE REGULATION OF MOLECULAR FUNCTION 17 1079 1.382e-08 2.679e-06
25 DEFENSE RESPONSE 18 1231 1.48e-08 2.755e-06
26 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 19 1395 1.659e-08 2.97e-06
27 IMMUNE RESPONSE 17 1100 1.836e-08 3.164e-06
28 REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1618 3.168e-08 5.264e-06
29 LEUKOCYTE ACTIVATION 11 414 4.323e-08 6.936e-06
30 POSITIVE REGULATION OF LOCOMOTION 11 420 5.004e-08 7.167e-06
31 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 19 1492 4.882e-08 7.167e-06
32 NEGATIVE REGULATION OF NEURON DEATH 8 171 4.853e-08 7.167e-06
33 BIOLOGICAL ADHESION 16 1032 5.083e-08 7.167e-06
34 CELLULAR COMPONENT MORPHOGENESIS 15 900 5.669e-08 7.758e-06
35 NEURON PROJECTION DEVELOPMENT 12 545 7.674e-08 9.986e-06
36 LYMPHOCYTE ACTIVATION 10 342 7.801e-08 9.986e-06
37 REGULATION OF PROTEIN MODIFICATION PROCESS 20 1710 7.941e-08 9.986e-06
38 REGULATION OF CELL MORPHOGENESIS 12 552 8.814e-08 1.079e-05
39 CELL ACTIVATION 12 568 1.201e-07 1.397e-05
40 REGULATION OF NEURON APOPTOTIC PROCESS 8 192 1.188e-07 1.397e-05
41 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 1.454e-07 1.65e-05
42 CELL MOTILITY 14 835 1.588e-07 1.666e-05
43 LOCALIZATION OF CELL 14 835 1.588e-07 1.666e-05
44 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 17 1275 1.568e-07 1.666e-05
45 REGULATION OF CELL DEVELOPMENT 14 836 1.611e-07 1.666e-05
46 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 7 135 1.758e-07 1.779e-05
47 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 16 1135 1.874e-07 1.856e-05
48 CELL DEATH 15 1001 2.256e-07 2.163e-05
49 LYMPHOCYTE DIFFERENTIATION 8 209 2.278e-07 2.163e-05
50 LEUKOCYTE DIFFERENTIATION 9 292 2.377e-07 2.212e-05
51 REGULATION OF CATABOLIC PROCESS 13 731 2.427e-07 2.214e-05
52 REGULATION OF PROTEIN CATABOLIC PROCESS 10 393 2.828e-07 2.437e-05
53 NEURON DIFFERENTIATION 14 874 2.767e-07 2.437e-05
54 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 11 498 2.776e-07 2.437e-05
55 EXTRACELLULAR STRUCTURE ORGANIZATION 9 304 3.337e-07 2.823e-05
56 NEURON PROJECTION MORPHOGENESIS 10 402 3.481e-07 2.893e-05
57 PROTEOLYSIS 16 1208 4.349e-07 3.55e-05
58 NEGATIVE REGULATION OF PROTEOLYSIS 9 329 6.466e-07 5.187e-05
59 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 13 801 6.853e-07 5.405e-05
60 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 337 7.897e-07 6.125e-05
61 REGULATION OF CELL PROJECTION ORGANIZATION 11 558 8.538e-07 6.513e-05
62 NEURON DEVELOPMENT 12 687 9.127e-07 6.842e-05
63 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 12 689 9.41e-07 6.842e-05
64 REGULATION OF NEURON DEATH 8 252 9.407e-07 6.842e-05
65 NEURON MIGRATION 6 110 1.048e-06 7.499e-05
66 RESPONSE TO CYTOKINE 12 714 1.367e-06 9.636e-05
67 REGULATION OF CELL DIFFERENTIATION 17 1492 1.43e-06 9.93e-05
68 POSITIVE REGULATION OF PROTEOLYSIS 9 363 1.461e-06 9.999e-05
69 REGULATION OF CELL PROLIFERATION 17 1496 1.484e-06 1e-04
70 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 9 368 1.636e-06 0.0001087
71 POSITIVE REGULATION OF CATALYTIC ACTIVITY 17 1518 1.814e-06 0.0001189
72 CELL CYCLE CHECKPOINT 7 194 2.031e-06 0.0001313
73 REGULATION OF BINDING 8 283 2.239e-06 0.0001427
74 POSITIVE REGULATION OF BINDING 6 127 2.429e-06 0.0001527
75 REGULATION OF PEPTIDASE ACTIVITY 9 392 2.746e-06 0.0001703
76 POSITIVE REGULATION OF PROTEIN BINDING 5 73 2.86e-06 0.0001747
77 CELL PART MORPHOGENESIS 11 633 2.904e-06 0.0001747
78 NEURON PROJECTION GUIDANCE 7 205 2.929e-06 0.0001747
79 REGULATION OF IMMUNE SYSTEM PROCESS 16 1403 3.128e-06 0.0001843
80 EXTRACELLULAR MATRIX DISASSEMBLY 5 76 3.494e-06 0.0002032
81 GLIAL CELL DIFFERENTIATION 6 136 3.615e-06 0.0002077
82 REGULATION OF NEURON PROJECTION DEVELOPMENT 9 408 3.803e-06 0.0002158
83 REGULATION OF MAPK CASCADE 11 660 4.332e-06 0.0002344
84 REGULATION OF SYNAPTIC PLASTICITY 6 140 4.275e-06 0.0002344
85 PROTEIN PHOSPHORYLATION 13 944 4.237e-06 0.0002344
86 POSITIVE REGULATION OF ERBB SIGNALING PATHWAY 4 36 4.288e-06 0.0002344
87 INTERSPECIES INTERACTION BETWEEN ORGANISMS 11 662 4.458e-06 0.0002357
88 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 11 662 4.458e-06 0.0002357
89 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 4.832e-06 0.0002526
90 POSITIVE REGULATION OF CELL DIFFERENTIATION 12 823 5.911e-06 0.0003056
91 REGULATION OF NEURON DIFFERENTIATION 10 554 6.21e-06 0.0003175
92 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 14 1142 6.515e-06 0.0003295
93 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 7 232 6.613e-06 0.0003309
94 RESPONSE TO WOUNDING 10 563 7.152e-06 0.000354
95 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 7 245 9.438e-06 0.0004623
96 SINGLE ORGANISM CELL ADHESION 9 459 9.829e-06 0.0004764
97 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 12 867 1.001e-05 0.0004802
98 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 15 1360 1.024e-05 0.0004861
99 REGULATION OF PROTEIN BINDING 6 168 1.217e-05 0.0005668
100 FOREBRAIN DEVELOPMENT 8 357 1.23e-05 0.0005668
101 POSITIVE REGULATION OF CELL DEVELOPMENT 9 472 1.228e-05 0.0005668
102 INTRACELLULAR SIGNAL TRANSDUCTION 16 1572 1.333e-05 0.000608
103 LEUKOCYTE MIGRATION 7 259 1.354e-05 0.0006115
104 REGULATION OF APOPTOTIC SIGNALING PATHWAY 8 363 1.388e-05 0.0006209
105 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 1.416e-05 0.0006276
106 CELL PROJECTION ORGANIZATION 12 902 1.488e-05 0.0006532
107 GLIOGENESIS 6 175 1.535e-05 0.0006675
108 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 10 616 1.563e-05 0.0006734
109 RESPONSE TO EXTERNAL STIMULUS 17 1821 2.07e-05 0.0008835
110 POSITIVE REGULATION OF TRANSPORT 12 936 2.149e-05 0.0009091
111 POSITIVE REGULATION OF CATABOLIC PROCESS 8 395 2.545e-05 0.001048
112 REGULATION OF RESPONSE TO STRESS 15 1468 2.534e-05 0.001048
113 ERROR PRONE TRANSLESION SYNTHESIS 3 19 2.526e-05 0.001048
114 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 8 397 2.638e-05 0.001077
115 VIRAL LIFE CYCLE 7 290 2.8e-05 0.001133
116 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 6 195 2.828e-05 0.001134
117 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 200 3.26e-05 0.001296
118 RHYTHMIC PROCESS 7 298 3.33e-05 0.001313
119 REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 3 21 3.453e-05 0.00135
120 REGULATION OF HYDROLASE ACTIVITY 14 1327 3.526e-05 0.001365
121 MODULATION OF SYNAPTIC TRANSMISSION 7 301 3.549e-05 0.001365
122 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 7 303 3.702e-05 0.001412
123 FOREBRAIN CELL MIGRATION 4 62 3.827e-05 0.001448
124 ENDOCARDIAL CUSHION MORPHOGENESIS 3 22 3.989e-05 0.001497
125 ORGAN MORPHOGENESIS 11 841 4.151e-05 0.001545
126 NEGATIVE REGULATION OF ION TRANSPORT 5 127 4.269e-05 0.001576
127 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 213 4.635e-05 0.001698
128 REGULATION OF IMMUNE RESPONSE 11 858 4.977e-05 0.001809
129 NEGATIVE REGULATION OF CELL COMMUNICATION 13 1192 5.041e-05 0.001818
130 POSITIVE REGULATION OF NEURON DEATH 4 67 5.199e-05 0.001819
131 REGULATION OF NOTCH SIGNALING PATHWAY 4 67 5.199e-05 0.001819
132 RESPONSE TO ABIOTIC STIMULUS 12 1024 5.176e-05 0.001819
133 REGULATION OF MAP KINASE ACTIVITY 7 319 5.128e-05 0.001819
134 CELLULAR RESPONSE TO STRESS 15 1565 5.325e-05 0.001849
135 IMMUNE SYSTEM DEVELOPMENT 9 582 6.33e-05 0.002182
136 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 5 139 6.565e-05 0.00223
137 MITOTIC CELL CYCLE CHECKPOINT 5 139 6.565e-05 0.00223
138 INFLAMMATORY RESPONSE 8 454 6.802e-05 0.002289
139 PHOSPHORYLATION 13 1228 6.839e-05 0.002289
140 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 16 1805 7.251e-05 0.00241
141 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 6 232 7.443e-05 0.002456
142 RESPONSE TO TUMOR NECROSIS FACTOR 6 233 7.622e-05 0.002498
143 TAXIS 8 464 7.918e-05 0.002576
144 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 145 8.022e-05 0.002592
145 SENSORY PERCEPTION OF PAIN 4 75 8.096e-05 0.002598
146 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 10 750 8.264e-05 0.002623
147 T CELL RECEPTOR SIGNALING PATHWAY 5 146 8.287e-05 0.002623
148 RESPONSE TO COPPER ION 3 28 8.376e-05 0.002633
149 POSITIVE REGULATION OF MAPK CASCADE 8 470 8.658e-05 0.002686
150 CELLULAR RESPONSE TO CYTOKINE STIMULUS 9 606 8.624e-05 0.002686
151 RESPONSE TO TRANSITION METAL NANOPARTICLE 5 148 8.838e-05 0.002723
152 RESPONSE TO GROWTH FACTOR 8 475 9.317e-05 0.002852
153 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 16 1848 9.599e-05 0.002919
154 INNATE IMMUNE RESPONSE 9 619 0.0001014 0.003062
155 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 0.0001031 0.003095
156 REGULATION OF KINASE ACTIVITY 10 776 0.0001095 0.003266
157 REGULATION OF CELL ADHESION 9 629 0.0001144 0.003392
158 REGULATION OF TRANSFERASE ACTIVITY 11 946 0.0001192 0.003509
159 REGULATION OF ERBB SIGNALING PATHWAY 4 83 0.0001202 0.003517
160 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 0.0001257 0.003589
161 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 0.0001257 0.003589
162 BLOOD VESSEL REMODELING 3 32 0.0001257 0.003589
163 LEUKOCYTE CELL CELL ADHESION 6 255 0.0001251 0.003589
164 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 11 957 0.0001319 0.003698
165 PALATE DEVELOPMENT 4 85 0.0001318 0.003698
166 EPHRIN RECEPTOR SIGNALING PATHWAY 4 85 0.0001318 0.003698
167 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 162 0.0001352 0.003723
168 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 5 162 0.0001352 0.003723
169 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 162 0.0001352 0.003723
170 MOVEMENT IN ENVIRONMENT OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 4 87 0.0001443 0.003789
171 ENTRY INTO CELL OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 4 87 0.0001443 0.003789
172 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 262 0.000145 0.003789
173 PROTEIN LOCALIZATION TO MEMBRANE 7 376 0.000143 0.003789
174 VIRAL ENTRY INTO HOST CELL 4 87 0.0001443 0.003789
175 ENTRY INTO OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 4 87 0.0001443 0.003789
176 MOVEMENT IN HOST ENVIRONMENT 4 87 0.0001443 0.003789
177 ENTRY INTO HOST 4 87 0.0001443 0.003789
178 ENTRY INTO HOST CELL 4 87 0.0001443 0.003789
179 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 6 263 0.000148 0.003847
180 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 3 34 0.000151 0.003862
181 AGING 6 264 0.0001511 0.003862
182 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 0.0001508 0.003862
183 PROTEIN MATURATION 6 265 0.0001542 0.003921
184 B CELL DIFFERENTIATION 4 89 0.0001575 0.003984
185 REGULATION OF AXONOGENESIS 5 168 0.0001603 0.004032
186 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 0.0001619 0.00405
187 POSITIVE REGULATION OF GENE EXPRESSION 15 1733 0.0001683 0.004187
188 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 6 274 0.0001848 0.004574
189 VIRION ASSEMBLY 3 37 0.0001948 0.004796
190 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 95 0.0002026 0.004962
191 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 4 96 0.0002109 0.005115
192 MESENCHYME MORPHOGENESIS 3 38 0.0002111 0.005115
193 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 5 179 0.0002154 0.005192
194 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 7 404 0.0002222 0.005329
195 ERBB2 SIGNALING PATHWAY 3 39 0.0002282 0.005389
196 POSITIVE REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 3 39 0.0002282 0.005389
197 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 3 39 0.0002282 0.005389
198 REGULATION OF TRANSPORT 15 1804 0.0002616 0.006148
199 TRANSLESION SYNTHESIS 3 41 0.000265 0.006165
200 RECEPTOR CLUSTERING 3 41 0.000265 0.006165
201 CENTRAL NERVOUS SYSTEM DEVELOPMENT 10 872 0.0002819 0.006527
202 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 5 191 0.0002907 0.006697
203 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 5 192 0.0002978 0.006793
204 CEREBRAL CORTEX DEVELOPMENT 4 105 0.0002974 0.006793
205 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 4 106 0.0003084 0.006999
206 NEGATIVE REGULATION OF CELL DEVELOPMENT 6 303 0.0003174 0.007168
207 REGULATION OF SEQUESTERING OF CALCIUM ION 4 107 0.0003196 0.007185
208 REGULATION OF CELL CYCLE ARREST 4 108 0.0003312 0.007408
209 POSITIVE REGULATION OF NEURON DIFFERENTIATION 6 306 0.0003345 0.007412
210 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 8 573 0.0003345 0.007412
211 NEGATIVE REGULATION OF CELL CYCLE 7 433 0.0003382 0.007458
212 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 4 109 0.000343 0.007528
213 POSITIVE REGULATION OF RECEPTOR ACTIVITY 3 45 0.0003497 0.007634
214 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 5 199 0.0003511 0.007634
215 IN UTERO EMBRYONIC DEVELOPMENT 6 311 0.0003646 0.007855
216 RESPONSE TO OXYGEN LEVELS 6 311 0.0003646 0.007855
217 REGULATION OF ION HOMEOSTASIS 5 201 0.0003676 0.007882
218 ZYMOGEN ACTIVATION 4 112 0.0003803 0.008118
219 OVULATION CYCLE 4 113 0.0003934 0.008358
220 REGULATION OF ION TRANSPORT 8 592 0.0004157 0.008793
221 FEMALE SEX DIFFERENTIATION 4 116 0.0004345 0.009148
222 CYTOKINE MEDIATED SIGNALING PATHWAY 7 452 0.0004376 0.009171
223 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 323 0.0004457 0.009299
224 REGULATION OF NEURONAL SYNAPTIC PLASTICITY 3 49 0.0004501 0.009349
225 SKELETAL SYSTEM DEVELOPMENT 7 455 0.0004552 0.009414
226 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 4 118 0.0004636 0.009544
227 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 213 0.0004791 0.00982
NumGOOverlapSizeP ValueAdj. P Value
1 METALLOENDOPEPTIDASE ACTIVITY 7 113 5.168e-08 2.092e-05
2 BETA AMYLOID BINDING 5 35 6.756e-08 2.092e-05
3 RECEPTOR BINDING 19 1476 4.11e-08 2.092e-05
4 METALLOPEPTIDASE ACTIVITY 7 188 1.648e-06 0.0003827
5 TAU PROTEIN BINDING 3 12 5.824e-06 0.001074
6 ZINC ION BINDING 14 1155 7.417e-06 0.001074
7 ENDOPEPTIDASE ACTIVITY 9 448 8.094e-06 0.001074
8 PEPTIDASE ACTIVITY 10 663 2.934e-05 0.003407
9 TRANSITION METAL ION BINDING 14 1400 6.33e-05 0.005881
10 IDENTICAL PROTEIN BINDING 13 1209 5.83e-05 0.005881
11 SERINE HYDROLASE ACTIVITY 6 242 9.39e-05 0.007931
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX 14 426 2.896e-11 1.285e-08
2 PROTEINACEOUS EXTRACELLULAR MATRIX 13 356 4.402e-11 1.285e-08
3 EXTRACELLULAR SPACE 18 1376 8.147e-08 1.586e-05
4 IMMUNOLOGICAL SYNAPSE 4 33 2.999e-06 0.0004379
5 SIDE OF MEMBRANE 8 428 4.496e-05 0.005252
6 CELL SURFACE 10 757 8.925e-05 0.007446
7 EXTERNAL SIDE OF PLASMA MEMBRANE 6 238 8.568e-05 0.007446
8 CELL BODY 8 494 0.0001222 0.008919

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Notch_signaling_pathway_hsa04330 5 48 3.457e-07 1.798e-05
2 Apoptosis_hsa04210 5 138 6.344e-05 0.001649
3 Apoptosis_multiple_species_hsa04215 3 33 0.000138 0.002392
4 Focal_adhesion_hsa04510 4 199 0.003188 0.03805
5 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.00436 0.03805
6 TNF_signaling_pathway_hsa04668 3 108 0.004391 0.03805
7 Sphingolipid_signaling_pathway_hsa04071 3 118 0.005618 0.04174
8 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.009885 0.06425
9 MAPK_signaling_pathway_hsa04010 4 295 0.01253 0.0724
10 Adherens_junction_hsa04520 2 72 0.0204 0.1061
11 Rap1_signaling_pathway_hsa04015 3 206 0.02504 0.1126
12 ECM_receptor_interaction_hsa04512 2 82 0.02599 0.1126
13 Ras_signaling_pathway_hsa04014 3 232 0.0339 0.1266
14 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.03408 0.1266
15 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.0494 0.1713
16 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.07327 0.2381
17 Necroptosis_hsa04217 2 164 0.0894 0.2735
18 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.1325 0.3828

Quest ID: fa83e066c02b5a525bcf56e7891a8e31