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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-5p ASPM -0.03 0.25442 2.01 0 miRNAWalker2 validate -3.72 0
2 hsa-let-7a-5p CCNB2 -0.03 0.25442 1.87 0 miRNAWalker2 validate -3.92 0
3 hsa-let-7a-5p RRM2 -0.03 0.25442 1.6 0 miRNAWalker2 validate; TargetScan; miRNATAP -3.21 0
4 hsa-let-7b-5p BIRC5 -0.12 0.00077 1.89 0 miRNAWalker2 validate -4.17 0
5 hsa-let-7b-5p CCNB1 -0.12 0.00077 1.59 0 miRNAWalker2 validate -3.89 0
6 hsa-let-7b-5p CCNB2 -0.12 0.00077 1.87 0 miRNAWalker2 validate -4.32 0
7 hsa-let-7b-5p CDCA8 -0.12 0.00077 1.9 0 miRNAWalker2 validate -4.01 0
8 hsa-let-7b-5p RRM2 -0.12 0.00077 1.6 0 miRNAWalker2 validate; miRNATAP -3.62 0
9 hsa-let-7c-5p CCNB2 -0.13 0.00086 1.87 0 miRNAWalker2 validate -4.54 0
10 hsa-let-7e-5p MKI67 -0.06 0.0129 1.67 0 miRNAWalker2 validate -4.4 0
11 hsa-miR-100-5p RRM2 -0.14 0.00081 1.6 0 miRNAWalker2 validate -3.6 0
12 hsa-miR-101-3p BIRC5 -0.13 4.0E-5 1.89 0 miRNAWalker2 validate -5.94 0
13 hsa-miR-10a-5p BIRC5 -0.29 0 1.89 0 miRNAWalker2 validate -3.79 0
14 hsa-miR-122-5p CENPF -0.14 0.00123 1.92 0 miRNAWalker2 validate -3.98 0
15 hsa-miR-124-3p BEX1 0.08 0.04068 -1.68 0 miRNAWalker2 validate -1.46 0.02553
16 hsa-miR-124-3p ID1 0.08 0.04068 -1.66 0 miRNAWalker2 validate -0.96 0.03411
17 hsa-miR-124-3p MFAP4 0.08 0.04068 -1.79 0 miRNAWalker2 validate -1.66 0.00453
18 hsa-miR-125a-5p PRC1 -0.13 0.00014 1.59 0 miRNAWalker2 validate -3.56 0
19 hsa-miR-125b-5p HOXA13 -0.19 1.0E-5 1.81 0 miRNAWalker2 validate -2.15 0.00011
20 hsa-miR-128-3p LIFR 0.08 0.0018 -1.71 0 miRNAWalker2 validate -3.77 0
21 hsa-miR-128-3p RELN 0.08 0.0018 -1.76 0 miRNAWalker2 validate; miRTarBase; MirTarget -4.11 1.0E-5
22 hsa-miR-132-3p CYP26A1 0.04 0.33877 -1.78 0 miRNAWalker2 validate -1.32 0.03036
23 hsa-miR-146a-5p CDKN3 -0.15 0.00019 1.99 0 miRNAWalker2 validate -2.83 0
24 hsa-miR-148b-3p CCL19 0.14 0 -1.9 0 miRNAWalker2 validate -6.88 0
25 hsa-miR-148b-3p DPT 0.14 0 -2.5 0 miRNAWalker2 validate -8.78 0
26 hsa-miR-148b-3p IL13RA2 0.14 0 -2.45 0 miRNAWalker2 validate -5.71 0
27 hsa-miR-15b-5p BEX1 0.17 0 -1.68 0 miRNAWalker2 validate -5.39 0
28 hsa-miR-16-5p CRHBP 0.05 0.02313 -3.12 0 miRNAWalker2 validate -6.39 1.0E-5
29 hsa-miR-192-5p ANLN 0.01 0.72622 2.11 0 miRNAWalker2 validate -1.76 0.01044
30 hsa-miR-192-5p ASPM 0.01 0.72622 2.01 0 miRNAWalker2 validate -1.66 0.011
31 hsa-miR-192-5p CDKN3 0.01 0.72622 1.99 0 miRNAWalker2 validate -1.51 0.01409
32 hsa-miR-192-5p CENPA 0.01 0.72622 1.91 0 miRNAWalker2 validate -1.82 0.00402
33 hsa-miR-192-5p CENPE 0.01 0.72622 1.59 0 miRNAWalker2 validate -2.03 0.00015
34 hsa-miR-192-5p CENPF 0.01 0.72622 1.92 0 miRNAWalker2 validate -1.9 0.00192
35 hsa-miR-192-5p DTL 0.01 0.72622 1.64 0 miRNAWalker2 validate -1.34 0.01789
36 hsa-miR-192-5p E2F8 0.01 0.72622 1.83 0 miRNAWalker2 validate -1.16 0.04535
37 hsa-miR-192-5p KIF20A 0.01 0.72622 1.86 0 miRNAWalker2 validate -1.83 0.00359
38 hsa-miR-192-5p MKI67 0.01 0.72622 1.67 0 miRNAWalker2 validate; mirMAP -2.04 0.00041
39 hsa-miR-192-5p NUF2 0.01 0.72622 1.95 0 miRNAWalker2 validate -2.03 0.00155
40 hsa-miR-192-5p PAK6 0.01 0.72622 1.6 0 miRNAWalker2 validate -1.72 0.00123
41 hsa-miR-192-5p RAB3B 0.01 0.72622 1.83 0 miRNAWalker2 validate; mirMAP -2.28 0.00384
42 hsa-miR-192-5p TTK 0.01 0.72622 1.73 0 miRNAWalker2 validate -2.05 0.00054
43 hsa-miR-21-5p LIFR 0.23 0.00018 -1.71 0 miRNAWalker2 validate -1.81 0
44 hsa-miR-215-5p CENPE 0.04 0.21421 1.59 0 miRNAWalker2 validate -1.52 0.00355
45 hsa-miR-215-5p CENPF 0.04 0.21421 1.92 0 miRNAWalker2 validate -1.44 0.01556
46 hsa-miR-215-5p ID1 0.04 0.21421 -1.66 0 miRNAWalker2 validate -1.32 0.01002
47 hsa-miR-215-5p KIF20A 0.04 0.21421 1.86 0 miRNAWalker2 validate -1.26 0.03958
48 hsa-miR-215-5p MKI67 0.04 0.21421 1.67 0 miRNAWalker2 validate -1.46 0.00933
49 hsa-miR-215-5p NUF2 0.04 0.21421 1.95 0 miRNAWalker2 validate -1.46 0.01959
50 hsa-miR-215-5p PAK6 0.04 0.21421 1.6 0 miRNAWalker2 validate -1.25 0.01669
51 hsa-miR-215-5p RAB3B 0.04 0.21421 1.83 0 miRNAWalker2 validate -1.57 0.04108
52 hsa-miR-215-5p TTK 0.04 0.21421 1.73 0 miRNAWalker2 validate -1.51 0.00889
53 hsa-miR-23a-3p KIF20A -0.02 0.18092 1.86 0 miRNAWalker2 validate -4.7 0.00011
54 hsa-miR-23b-3p CCNB2 0.01 0.57764 1.87 0 miRNAWalker2 validate -3.74 0.00154
55 hsa-miR-23b-3p CDCA8 0.01 0.57764 1.9 0 miRNAWalker2 validate -2.69 0.01297
56 hsa-miR-24-3p BEX1 -0.01 0.59303 -1.68 0 miRNAWalker2 validate -3.13 0.02097
57 hsa-miR-24-3p CCNB1 -0.01 0.59303 1.59 0 miRNAWalker2 validate -3.31 0.00049
58 hsa-miR-24-3p DTL -0.01 0.59303 1.64 0 miRNAWalker2 validate -2.21 0.02677
59 hsa-miR-24-3p RRM2 -0.01 0.59303 1.6 0 miRNAWalker2 validate -3.08 0.00198
60 hsa-miR-24-3p UBE2C -0.01 0.59303 1.89 0 miRNAWalker2 validate -3.91 0.0003
61 hsa-miR-26a-5p RRM2 -0.08 7.0E-5 1.6 0 miRNAWalker2 validate -5.75 0
62 hsa-miR-26b-5p ASPM -0.05 0.04928 2.01 0 miRNAWalker2 validate -5.79 0
63 hsa-miR-26b-5p DTL -0.05 0.04928 1.64 0 miRNAWalker2 validate -4.55 0
64 hsa-miR-26b-5p FOXM1 -0.05 0.04928 1.79 0 miRNAWalker2 validate -5.76 0
65 hsa-miR-26b-5p PAK6 -0.05 0.04928 1.6 0 miRNAWalker2 validate -5.13 0
66 hsa-miR-26b-5p SPC25 -0.05 0.04928 1.93 0 miRNAWalker2 validate -5.75 0
67 hsa-miR-30a-5p DTL -0.1 0.00105 1.64 0 miRNAWalker2 validate; miRTarBase -2.81 0 22287560 Combining global gene expression analyses of miR-30a-5p transgenic line HCT116 with in silico miRNA target prediction we identified the denticleless protein homolog DTL as a potential miRNA-30a-5p target
68 hsa-miR-30a-5p RRM2 -0.1 0.00105 1.6 0 miRNAWalker2 validate -2.62 0
69 hsa-miR-30c-5p BIRC5 -0.05 0.0598 1.89 0 miRNAWalker2 validate -5.67 0
70 hsa-miR-30c-5p CELSR3 -0.05 0.0598 1.59 0 miRNAWalker2 validate; MirTarget; miRNATAP -3.83 0
71 hsa-miR-30c-5p RRM2 -0.05 0.0598 1.6 0 miRNAWalker2 validate -5.2 0
72 hsa-miR-30e-5p EXO1 -0.03 0.2867 1.64 0 miRNAWalker2 validate -3.08 0
73 hsa-miR-324-5p APOF 0.23 0 -1.83 0 miRNAWalker2 validate -5.34 0
74 hsa-miR-335-5p CCL19 0.02 0.79934 -1.9 0 miRNAWalker2 validate -0.72 0.02147
75 hsa-miR-335-5p NGFR 0.02 0.79934 -1.59 0 miRNAWalker2 validate -0.65 0.00518
76 hsa-miR-375 CENPF -0.55 0 1.92 0 miRNAWalker2 validate -1.22 0
77 hsa-miR-375 EXO1 -0.55 0 1.64 0 miRNAWalker2 validate -1.09 0
78 hsa-miR-375 RAB3B -0.55 0 1.83 0 miRNAWalker2 validate -0.56 0.02581
79 hsa-miR-424-5p ANLN -0.16 0 2.11 0 miRNAWalker2 validate; miRTarBase -5.97 0
80 hsa-miR-9-5p CCL19 0.21 0.00475 -1.9 0 miRNAWalker2 validate -1.05 0.00113
81 hsa-miR-9-5p CYP39A1 0.21 0.00475 -1.72 0 miRNAWalker2 validate -1.02 0.00037
82 hsa-miR-98-5p LIFR 0.11 0.00295 -1.71 0 miRNAWalker2 validate -1.72 0.00018
83 hsa-miR-221-3p DIRAS3 0.19 0 -1.7 0 miRTarBase -4.22 0 22117988; 22117988; 22117988; 22117988; 23801152; 23801152; 23801152; 23801152; 21071579; 21071579; 21071579 The expression and clinical significance of GTP-binding RAS-like 3 ARHI and microRNA 221 and 222 in prostate cancer;MicroRNA 221 and 222 have been shown to regulate ARHI expression negatively;Expression of ARHI and microRNA 221 and 222 was measured by real-time reverse transcription-polymerase chain reaction;Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation;The downregulation of ARHI was regulated by miR-221 in prostate cancer cell lines;The inhibition of miR-221 induced a significant upregulation of ARHI in MCF-7 cells;To prove a direct interaction between miR-221 and ARHI mRNA ARHI 3'UTR which includes the potential target site for miR-221 was cloned downstream of the luciferase reporter gene of the pMIR-REPORT vector to generate the pMIR-ARHI-3'UTR vector;This study demonstrated for the first time that the downregulation of ARHI in breast cancer cells could be regulated by miR-221;Further studies on a new mechanism of ARHI downregulation showed a significant inverse relationship between ARHI and miR-221 and 222 which were upregulated in prostate cancer cell lines;Transfection of miR-221 and 222 inhibitors into PC-3 cells caused a significant induction of ARHI expression;Finally we also found that genistein upregulates ARHI by downregulating miR-221 and 222 in PC-3 cells
84 hsa-miR-222-3p DIRAS3 0.15 3.0E-5 -1.7 0 miRTarBase -4.33 0
85 hsa-miR-218-5p BIRC5 -0.14 0.00268 1.89 0 miRTarBase; MirTarget -1.51 0.00025
86 hsa-miR-203a-3p BIRC5 -0.27 3.0E-5 1.89 0 miRTarBase -1.62 0
87 hsa-miR-21-5p NTF3 0.23 0.00018 -1.58 0 miRTarBase; miRNATAP -1.78 0
88 hsa-miR-103a-3p LRRN3 0.11 0 -1.69 0 MirTarget; miRNATAP -4.41 0
89 hsa-miR-105-5p CLDN10 0.17 0.00159 -2.25 0 MirTarget -1.51 0.00044
90 hsa-miR-106a-5p LRRC55 0.05 0.12421 -1.67 0 MirTarget -1.81 0.00165
91 hsa-miR-106a-5p KCNJ10 0.05 0.12421 -1.63 0 MirTarget; miRNATAP -1.31 0.01777
92 hsa-miR-106b-5p LRRC55 0.17 0 -1.67 0 MirTarget -5.56 0
93 hsa-miR-106b-5p KCNJ10 0.17 0 -1.63 0 MirTarget; miRNATAP -5 0
94 hsa-miR-107 LRRN3 0.13 0 -1.69 0 MirTarget; PITA; miRanda; miRNATAP -2.98 0
95 hsa-miR-126-5p MELK 0 0.93995 1.86 0 MirTarget -3.22 8.0E-5
96 hsa-miR-128-3p LRAT 0.08 0.0018 -2.15 0 MirTarget -4.55 0
97 hsa-miR-128-3p CLRN3 0.08 0.0018 -1.93 0 MirTarget -3.78 0.00027
98 hsa-miR-135a-5p BMPER 0.26 0.01554 -2.99 0 MirTarget; miRNATAP -1.43 0
99 hsa-miR-135a-5p ST6GAL2 0.26 0.01554 -2.01 0 MirTarget; miRNATAP -0.84 5.0E-5
100 hsa-miR-140-5p ST6GAL2 0.04 0.1479 -2.01 0 MirTarget; miRanda -2.44 0.00178
101 hsa-miR-142-5p CCNB1 -0.12 0.00783 1.59 0 MirTarget -1.38 0.0003
102 hsa-miR-144-3p E2F8 -0.11 0.02244 1.83 0 MirTarget; miRNATAP -1.82 0
103 hsa-miR-147a SYT9 0.09 0.00179 -1.93 0 MirTarget -2.3 0.00066
104 hsa-miR-147a CXCL14 0.09 0.00179 -2.84 0 MirTarget -4.74 0
105 hsa-miR-150-5p NEK2 -0.18 0.00075 2.04 0 MirTarget -2.19 0
106 hsa-miR-15a-5p LRRN3 0.01 0.57141 -1.69 0 MirTarget; miRNATAP -1.87 0.00306
107 hsa-miR-15a-5p RELN 0.01 0.57141 -1.76 0 MirTarget; miRNATAP -2.6 0.00634
108 hsa-miR-15a-5p RSPO3 0.01 0.57141 -2.56 0 MirTarget -4.07 6.0E-5
109 hsa-miR-15b-5p LRRN3 0.17 0 -1.69 0 MirTarget; miRNATAP -3.92 0
110 hsa-miR-15b-5p RELN 0.17 0 -1.76 0 MirTarget; miRNATAP -6.6 0
111 hsa-miR-15b-5p RSPO3 0.17 0 -2.56 0 MirTarget -7.32 0
112 hsa-miR-16-5p LRRN3 0.05 0.02313 -1.69 0 MirTarget; miRNATAP -3.18 5.0E-5
113 hsa-miR-16-5p RELN 0.05 0.02313 -1.76 0 MirTarget; miRNATAP -6.34 0
114 hsa-miR-16-5p RSPO3 0.05 0.02313 -2.56 0 MirTarget -6.2 0
115 hsa-miR-17-3p DPT 0.01 0.63304 -2.5 0 MirTarget -5.09 0.00054
116 hsa-miR-17-5p LRRC55 0.06 0.05778 -1.67 0 MirTarget; TargetScan -2.35 0.00014
117 hsa-miR-17-5p KCNJ10 0.06 0.05778 -1.63 0 MirTarget; TargetScan; miRNATAP -2.13 0.00031
118 hsa-miR-181b-5p TMEM27 0.04 0.18111 -1.83 0 MirTarget -1.92 0.01189
119 hsa-miR-181c-5p ESM1 -0.04 0.24874 2.3 0 MirTarget; miRNATAP -1.41 0.04857
120 hsa-miR-182-5p BMPER 0.14 0.00166 -2.99 0 MirTarget -3.49 0
121 hsa-miR-182-5p LRRC55 0.14 0.00166 -1.67 0 MirTarget -2.09 0
122 hsa-miR-185-5p CLEC4M 0.11 0 -3.6 0 MirTarget -9.02 0
123 hsa-miR-185-5p ADH4 0.11 0 -1.78 0 MirTarget -4.28 0.00025
124 hsa-miR-185-5p CFTR 0.11 0 -1.68 0 MirTarget -5.94 0
125 hsa-miR-185-5p KCNJ10 0.11 0 -1.63 0 MirTarget -4.14 0
126 hsa-miR-186-5p COL6A6 0.12 0 -1.8 0 MirTarget -3.66 0
127 hsa-miR-188-5p RSPO3 0.23 0 -2.56 0 MirTarget; PITA -7.86 0
128 hsa-miR-18a-5p FCGR2B 0.2 7.0E-5 -1.93 0 MirTarget -2.31 0
129 hsa-miR-194-5p DUSP9 0.03 0.38268 1.59 0 MirTarget; miRNATAP -3.32 0
130 hsa-miR-196b-5p SYT9 0.35 0 -1.93 0 MirTarget -1.6 0
131 hsa-miR-199a-3p PRC1 -0.47 0 1.59 0 MirTarget -1.81 0
132 hsa-miR-19a-3p RSPO3 0.02 0.47729 -2.56 0 MirTarget -2.79 0.00161
133 hsa-miR-200a-3p CDCA2 -0.48 0 1.62 0 MirTarget -1.01 0
134 hsa-miR-200a-3p DTL -0.48 0 1.64 0 MirTarget -1.08 0
135 hsa-miR-200b-3p ESM1 -0.53 0 2.3 0 MirTarget -1.66 0
136 hsa-miR-200b-3p MAGEC2 -0.53 0 1.62 0 MirTarget -1.57 0
137 hsa-miR-200b-3p ANLN -0.53 0 2.11 0 MirTarget; TargetScan -1.4 0
138 hsa-miR-202-3p SULT1C2 -0.19 0 1.58 1.0E-5 MirTarget -2.97 0
139 hsa-miR-203a-3p PRC1 -0.27 3.0E-5 1.59 0 MirTarget -1.51 0
140 hsa-miR-203a-3p SPC25 -0.27 3.0E-5 1.93 0 MirTarget -1.8 0
141 hsa-miR-204-5p GPC3 0.01 0.79023 1.83 0 MirTarget -0.95 0.02315
142 hsa-miR-204-5p CELSR3 0.01 0.79023 1.59 0 MirTarget; miRNATAP -0.74 0.01278
143 hsa-miR-206 RSPO3 0.03 0.13251 -2.56 0 MirTarget; PITA; miRanda -4.73 0.00013
144 hsa-miR-206 INMT 0.03 0.13251 -1.68 0 MirTarget; miRanda -4.66 0
145 hsa-miR-21-5p LPA 0.23 0.00018 -1.67 0 MirTarget -2.1 0
146 hsa-miR-211-5p DBH 0.09 0.01154 -2.08 0 MirTarget -1.82 0.00218
147 hsa-miR-212-3p BMPER 0.04 0.03172 -2.99 0 MirTarget -4.89 0.00336
148 hsa-miR-217 COL6A6 0.09 0.11729 -1.8 0 MirTarget; miRanda -1.23 0.00012
149 hsa-miR-224-5p NUDT10 0.35 6.0E-5 -1.77 0 MirTarget -1.19 0
150 hsa-miR-224-5p RELN 0.35 6.0E-5 -1.76 0 MirTarget -1.65 0

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 MITOTIC CELL CYCLE 29 766 2.272e-16 1.057e-12
2 CELL CYCLE 33 1316 1.892e-13 3.656e-10
3 CELL CYCLE PROCESS 30 1081 2.357e-13 3.656e-10
4 SISTER CHROMATID SEGREGATION 14 176 1.443e-12 1.678e-09
5 CHROMOSOME SEGREGATION 16 272 3.451e-12 3.212e-09
6 CELL DIVISION 19 460 1.397e-11 1.084e-08
7 MITOTIC NUCLEAR DIVISION 17 361 2.387e-11 1.587e-08
8 ORGANELLE FISSION 19 496 5.095e-11 2.634e-08
9 NUCLEAR CHROMOSOME SEGREGATION 14 228 4.793e-11 2.634e-08
10 SISTER CHROMATID COHESION 9 111 1.434e-08 6.674e-06
11 CELL CYCLE PHASE TRANSITION 12 255 2.491e-08 1.054e-05
12 REGULATION OF CHROMOSOME SEGREGATION 8 85 2.904e-08 1.126e-05
13 REGULATION OF NUCLEAR DIVISION 10 163 3.221e-08 1.153e-05
14 REGULATION OF CELL DIVISION 12 272 5.069e-08 1.685e-05
15 REGULATION OF SISTER CHROMATID SEGREGATION 7 67 1.065e-07 3.302e-05
16 MITOTIC SISTER CHROMATID SEGREGATION 7 91 8.855e-07 0.0002575
17 CHROMOSOME LOCALIZATION 6 61 1.292e-06 0.000334
18 CELL CYCLE G2 M PHASE TRANSITION 8 138 1.247e-06 0.000334
19 REGULATION OF EXIT FROM MITOSIS 4 16 1.728e-06 0.0004021
20 REGULATION OF CELL CYCLE 19 949 1.665e-06 0.0004021
21 MITOTIC SPINDLE ORGANIZATION 6 69 2.688e-06 0.0005956
22 METAPHASE PLATE CONGRESSION 5 42 3.96e-06 0.0008375
23 SPINDLE CHECKPOINT 4 25 1.155e-05 0.002336
24 NEGATIVE REGULATION OF CELL DIVISION 5 60 2.343e-05 0.004543
25 CHROMOSOME CONDENSATION 4 31 2.797e-05 0.005006
26 HYALURONAN METABOLIC PROCESS 4 31 2.797e-05 0.005006
27 REGULATION OF CELL PROLIFERATION 22 1496 3.287e-05 0.005664
28 REGULATION OF ORGANELLE ORGANIZATION 19 1178 3.586e-05 0.005959
29 KINETOCHORE ORGANIZATION 3 12 3.822e-05 0.006133
30 AMINOGLYCAN CATABOLIC PROCESS 5 68 4.313e-05 0.00669
31 NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY 7 170 5.433e-05 0.008155
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 CONDENSED CHROMOSOME 13 195 8.822e-11 5.152e-08
2 CHROMOSOME CENTROMERIC REGION 12 174 3.286e-10 9.596e-08
3 CONDENSED CHROMOSOME CENTROMERIC REGION 9 102 6.785e-09 1.321e-06
4 KINETOCHORE 9 120 2.844e-08 4.153e-06
5 CHROMOSOMAL REGION 12 330 4.091e-07 4.657e-05
6 CONDENSED CHROMOSOME OUTER KINETOCHORE 4 12 4.784e-07 4.657e-05
7 MIDBODY 8 132 8.903e-07 7.427e-05
8 SPINDLE 10 289 6.159e-06 0.0004496
9 CHROMOSOME 17 880 1e-05 0.000649
10 MICROTUBULE CYTOSKELETON 17 1068 0.0001137 0.006642
11 CONDENSED NUCLEAR CHROMOSOME CENTROMERIC REGION 3 18 0.0001383 0.007341
12 EXTRACELLULAR MATRIX 10 426 0.0001639 0.007979
13 PROTEINACEOUS EXTRACELLULAR MATRIX 9 356 0.0002036 0.009149

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa00830_Retinol_metabolism 4 387 0.1798 1
2 hsa04110_Cell_cycle 4 387 0.1798 1
3 hsa04062_Chemokine_signaling_pathway 3 387 0.3795 1
4 hsa04114_Oocyte_meiosis 3 387 0.3795 1
5 hsa04115_p53_signaling_pathway 3 387 0.3795 1
6 hsa04510_Focal_adhesion 3 387 0.3795 1
7 hsa04512_ECM.receptor_interaction 3 387 0.3795 1
8 hsa04630_Jak.STAT_signaling_pathway 3 387 0.3795 1
9 hsa04914_Progesterone.mediated_oocyte_maturation 3 387 0.3795 1
10 hsa04976_Bile_secretion 3 387 0.3795 1
11 hsa00340_Histidine_metabolism 2 387 0.6506 1
12 hsa00350_Tyrosine_metabolism 2 387 0.6506 1
13 hsa00380_Tryptophan_metabolism 2 387 0.6506 1
14 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 2 387 0.6506 1
15 hsa00982_Drug_metabolism_._cytochrome_P450 2 387 0.6506 1
16 hsa04010_MAPK_signaling_pathway 2 387 0.6506 1
17 hsa04145_Phagosome 2 387 0.6506 1
18 hsa04350_TGF.beta_signaling_pathway 2 387 0.6506 1
19 hsa04530_Tight_junction 2 387 0.6506 1
20 hsa04722_Neurotrophin_signaling_pathway 2 387 0.6506 1
21 hsa04971_Gastric_acid_secretion 2 387 0.6506 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

KCNQ1OT1

 hsa-let-7a-5p;hsa-let-7b-5p;hsa-let-7e-5p;hsa-miR-100-5p;hsa-miR-133b;hsa-miR-194-5p;hsa-miR-202-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-99a-5p 10 DUSP9 Sponge network 0.459 0.00259 1.595 0 0.658
2 FAM99A hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-132-3p;hsa-miR-148b-3p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-182-5p;hsa-miR-193a-3p;hsa-miR-21-5p 10 LRRC55 Sponge network -1.52 0 -1.671 0 0.527
3 GAS5 hsa-miR-130a-3p;hsa-miR-146a-5p;hsa-miR-192-5p;hsa-miR-199a-3p;hsa-miR-204-5p;hsa-miR-214-3p;hsa-miR-215-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29c-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-373-5p 13 RAB3B Sponge network 0.239 0.00543 1.829 0 0.517
4 SNHG6 hsa-miR-126-5p;hsa-miR-130a-3p;hsa-miR-133b;hsa-miR-192-5p;hsa-miR-199a-3p;hsa-miR-214-3p;hsa-miR-215-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-30a-5p 10 RAB3B Sponge network 0.28 0.00038 1.829 0 0.474
5

KCNQ1OT1

 hsa-let-7a-5p;hsa-let-7b-5p;hsa-let-7d-5p;hsa-let-7e-5p;hsa-miR-100-5p;hsa-miR-125a-5p;hsa-miR-199a-5p;hsa-miR-24-3p;hsa-miR-26a-5p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-373-5p 12 RRM2 Sponge network 0.459 0.00259 1.604 0 0.467
6

KTN1-AS1

 hsa-let-7a-5p;hsa-let-7b-5p;hsa-let-7e-5p;hsa-miR-100-5p;hsa-miR-133b;hsa-miR-194-5p;hsa-miR-202-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-99a-5p 10 DUSP9 Sponge network 0.382 0.00019 1.595 0 0.462
7

KCNQ1OT1

 hsa-miR-126-5p;hsa-miR-133b;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-192-5p;hsa-miR-199a-3p;hsa-miR-214-3p;hsa-miR-215-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-373-5p;hsa-miR-375 18 RAB3B Sponge network 0.459 0.00259 1.829 0 0.416
8

HCG18

 hsa-let-7a-5p;hsa-let-7b-5p;hsa-let-7e-5p;hsa-miR-100-5p;hsa-miR-125a-5p;hsa-miR-199a-5p;hsa-miR-26a-5p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-373-5p 10 RRM2 Sponge network 0.22 0.00721 1.604 0 0.41
9

KTN1-AS1

 hsa-miR-126-5p;hsa-miR-130a-3p;hsa-miR-133b;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-192-5p;hsa-miR-199a-3p;hsa-miR-214-3p;hsa-miR-215-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29c-3p;hsa-miR-30e-3p;hsa-miR-373-5p 14 RAB3B Sponge network 0.382 0.00019 1.829 0 0.396
10 MYCNOS hsa-let-7a-5p;hsa-let-7b-5p;hsa-let-7d-5p;hsa-let-7e-5p;hsa-miR-125a-5p;hsa-miR-199a-5p;hsa-miR-199b-5p;hsa-miR-24-3p;hsa-miR-26a-5p;hsa-miR-30a-5p;hsa-miR-30c-5p 11 RRM2 Sponge network 0.192 0.0041 1.604 0 0.384
11

HCG18

 hsa-miR-126-5p;hsa-miR-146a-5p;hsa-miR-192-5p;hsa-miR-199a-3p;hsa-miR-204-5p;hsa-miR-214-3p;hsa-miR-215-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-373-5p;hsa-miR-375 17 RAB3B Sponge network 0.22 0.00721 1.829 0 0.377
12 SNHG5 hsa-miR-106b-5p;hsa-miR-148b-3p;hsa-miR-182-5p;hsa-miR-193a-3p;hsa-miR-21-5p;hsa-miR-330-3p;hsa-miR-34a-5p;hsa-miR-34b-5p;hsa-miR-449a;hsa-miR-93-5p 10 LRRC55 Sponge network -0.338 1.0E-5 -1.671 0 0.364
13 SCARNA15 hsa-miR-130a-3p;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-199a-3p;hsa-miR-200b-3p;hsa-miR-204-5p;hsa-miR-214-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29c-3p;hsa-miR-30e-3p;hsa-miR-373-5p 12 RAB3B Sponge network 0.373 2.0E-5 1.829 0 0.32
14 FAM87B hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-214-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-375 10 RAB3B Sponge network 0.318 0.00507 1.829 0 0.314
15 PVT1 hsa-miR-130a-3p;hsa-miR-192-5p;hsa-miR-199a-3p;hsa-miR-200b-3p;hsa-miR-214-3p;hsa-miR-215-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-30c-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-373-5p 12 RAB3B Sponge network 0.192 0.00873 1.829 0 0.288

Quest ID: ff76bbd34e0071cce5bcfcd0bfc9c48c