miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-664a-3p APAF1 -0.256108763664991 0.0513188660751664 0.251747723736351 0.00842695067076781 mirMAP -0.133093485485973 2.59239090057129e-05 NA NA NA hsa-miR-18a-5p ATM 1.65455873230328 3.76457892277775e-20 -0.093354974252863 0.454138180986134 miRNAWalker2_validate;miRTarBase;MirTarget -0.172854853213816 1.55248713992951e-09 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 0.538732279378089 0.000622008277870679 -0.093354974252863 0.454138180986134 miRNAWalker2_validate -0.186784239327415 3.93187101386662e-08 NA NA NA hsa-miR-203a-3p ATM 0.0441399794719697 0.880456392176704 -0.093354974252863 0.454138180986134 MirTarget -0.104881351322909 9.03651632141775e-09 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-21-5p ATM 1.62465922021121 3.44191300985109e-58 -0.093354974252863 0.454138180986134 mirMAP -0.140220573701406 0.00355116923594901 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-30c-5p ATM 0.021222006155897 0.886366656528128 -0.093354974252863 0.454138180986134 mirMAP -0.12262645993067 0.000806314047643549 NA NA NA hsa-miR-339-5p ATM 1.07771430326938 2.45772601859307e-09 -0.093354974252863 0.454138180986134 miRanda -0.139243170775692 2.1104639922551e-06 NA NA NA hsa-miR-455-5p ATM 1.408595672323 5.52039116456697e-22 -0.093354974252863 0.454138180986134 miRanda -0.217802614613522 5.72421455047167e-10 NA NA NA hsa-miR-500a-5p ATM 0.675401699376111 8.24389004707854e-05 -0.093354974252863 0.454138180986134 mirMAP -0.142109646438286 5.47687546110341e-06 NA NA NA hsa-miR-576-5p ATM 0.940432050128373 6.90227595663302e-12 -0.093354974252863 0.454138180986134 mirMAP -0.165312006285652 1.91611455442744e-05 NA NA NA hsa-miR-590-5p ATM 0.763025362395968 3.65305892505623e-09 -0.093354974252863 0.454138180986134 mirMAP -0.147037048698993 0.000379931177124788 NA NA NA hsa-miR-92a-3p ATM 0.994679542307232 1.32587679156217e-16 -0.093354974252863 0.454138180986134 miRNAWalker2_validate -0.103772274344878 0.0183487891495439 NA NA NA hsa-miR-30b-5p ATR -0.400238605368173 0.00346540992719245 0.338492924444351 0.000892078828786625 mirMAP -0.107889073862237 0.000888694985860714 NA NA NA hsa-miR-374b-5p ATR -0.288413933608091 0.0041474558664058 0.338492924444351 0.000892078828786625 mirMAP -0.106771064141704 0.0165693822028123 NA NA NA hsa-miR-139-5p BBC3 -1.46099200329485 7.85040381494472e-22 0.908969832434519 2.81890699384748e-10 miRNATAP -0.219713232841052 3.65461069729995e-08 NA NA NA hsa-miR-144-3p BBC3 -1.64994343636831 1.13169944841075e-08 0.908969832434519 2.81890699384748e-10 miRNATAP -0.105802966202106 9.49962606775774e-07 NA NA NA hsa-miR-221-3p BBC3 0.410625614724387 0.000741090075261272 0.908969832434519 2.81890699384748e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12167946044098 0.0207110548390006 20813046;25585941 MiR 221 and miR 222 target PUMA to induce cell survival in glioblastoma;MiR 221 induced PUMA silencing mediates immune evasion of bladder cancer cells poor survival;immune evasion glioblastoma;bladder cancer hsa-miR-24-3p BBC3 0.13115428390042 0.203891651275156 0.908969832434519 2.81890699384748e-10 miRNATAP -0.230932302847746 0.000208687707166106 NA NA NA hsa-miR-338-5p BID -1.71946558699173 2.62649071488641e-23 0.969056554743071 1.68658061140478e-15 MirTarget -0.145216784372344 1.23781023880555e-06 NA NA NA hsa-miR-193b-3p CASP9 1.72788400801602 3.0722151264559e-21 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.154521744765018 3.59150879724078e-12 NA NA NA hsa-miR-424-5p CASP9 1.48125289532143 9.10372985713165e-19 -0.463384781945098 2.35696508685012e-06 mirMAP -0.139144406558183 1.49418335447692e-08 NA NA NA hsa-miR-7-5p CASP9 1.55674721532755 2.41989824363914e-11 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.103910716853992 3.37252845720189e-08 NA NA NA hsa-let-7b-5p CCNB1 -0.2489842756826 0.0211384499461719 1.44538211790055 1.41324264488903e-25 miRNAWalker2_validate -0.137154159733175 0.0202326535235778 NA NA NA hsa-miR-139-5p CCNB1 -1.46099200329485 7.85040381494472e-22 1.44538211790055 1.41324264488903e-25 miRanda -0.202873863849802 3.05511373822587e-07 NA NA NA hsa-let-7a-5p CCNB2 -0.439381775414001 3.1119785480023e-05 1.82527116734947 3.50769542184975e-39 miRNAWalker2_validate -0.171130721484154 0.00603586755919132 NA NA NA hsa-let-7b-5p CCNB2 -0.2489842756826 0.0211384499461719 1.82527116734947 3.50769542184975e-39 miRNAWalker2_validate -0.135176185068526 0.0273898364063523 NA NA NA hsa-let-7c-5p CCNB2 -2.07953368242668 3.46048888391218e-23 1.82527116734947 3.50769542184975e-39 miRNAWalker2_validate -0.203186123688501 4.53821488190806e-12 NA NA NA hsa-miR-339-5p CCNB3 1.07771430326938 2.45772601859307e-09 -0.696197499388971 0.00192746017407277 miRanda -0.107517206633162 0.0449385604292131 NA NA NA hsa-let-7g-5p CCND1 -0.250780249469264 0.00939610188330072 -0.0109881197784345 0.959465409721582 miRNATAP -0.424829740163156 1.3974509451707e-05 NA NA NA hsa-miR-106a-5p CCND1 0.67978010057847 0.00221925869726092 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.290355514799433 2.22440819238953e-12 NA NA NA hsa-miR-1266-5p CCND1 -0.595481713934774 0.0201336437562675 -0.0109881197784345 0.959465409721582 MirTarget -0.139245086566564 0.000186104290921039 NA NA NA hsa-miR-142-3p CCND1 1.12754191614028 1.68798138028946e-08 -0.0109881197784345 0.959465409721582 miRanda -0.212388247517233 4.15485864028608e-06 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 0.288897753038094 0.0900009317815725 -0.0109881197784345 0.959465409721582 PITA -0.191106128320911 0.000532572974747186 NA NA NA hsa-miR-150-5p CCND1 -0.243749814009231 0.331546276920338 -0.0109881197784345 0.959465409721582 mirMAP -0.180131286994855 1.27780213542857e-06 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15a-5p CCND1 0.783550182002274 2.60699595655907e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320464086146859 4.59241835770022e-05 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.85315666454713 3.79816274836297e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196519284459032 0.00913339894150689 NA NA NA hsa-miR-16-1-3p CCND1 0.955017760172879 5.95379292601146e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.299307340787817 2.12501301813106e-06 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.521122945828175 1.40561786410572e-06 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36160545188711 2.92815156758109e-05 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-19a-3p CCND1 1.35800152353624 2.80940447111944e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12556465980021 0.0080645437414565 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.757034032029085 2.99828133413343e-07 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.202417906859997 0.00132907107963613 NA NA NA hsa-miR-19b-3p CCND1 0.538732279378089 0.000622008277870679 -0.0109881197784345 0.959465409721582 miRNATAP -0.231848363677157 9.5371115518645e-05 NA NA NA hsa-miR-20a-5p CCND1 1.1531986665452 1.02385132917958e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150528956777027 0.00569825749150082 NA NA NA hsa-miR-20b-5p CCND1 0.345967670847176 0.232014828043601 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.250103392191291 2.8858693936891e-15 NA NA NA hsa-miR-26b-5p CCND1 -0.254478038884324 0.0285227763044636 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.1864018839503 0.0222087309699722 NA NA NA hsa-miR-29b-3p CCND1 -0.110721443686039 0.511264554091106 -0.0109881197784345 0.959465409721582 mirMAP -0.182509877041615 0.00109069300418897 NA NA NA hsa-miR-29c-3p CCND1 -2.08166260448948 8.3238369390898e-24 -0.0109881197784345 0.959465409721582 mirMAP -0.163903476961256 0.000152217345834049 NA NA NA hsa-miR-33a-3p CCND1 0.20371038027126 0.212335697664505 -0.0109881197784345 0.959465409721582 MirTarget -0.204409670414224 0.000471939794699908 NA NA NA hsa-miR-34a-5p CCND1 -0.117372471043915 0.364001947180738 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309736660444851 2.09961171943065e-05 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-374a-5p CCND1 -0.621903385111545 6.61791773205282e-12 -0.0109881197784345 0.959465409721582 MirTarget -0.226492767440786 0.028039247002316 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-425-5p CCND1 0.931027421598738 6.46235724408844e-08 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.149225802492201 0.00573052989307961 NA NA NA hsa-miR-497-5p CCND1 -0.966244470847844 5.26505649147857e-12 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.266892367444044 4.86480308910068e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 0.221436901462551 0.0965904764063157 -0.0109881197784345 0.959465409721582 mirMAP -0.238086291527056 0.000767975801470639 NA NA NA hsa-miR-7-1-3p CCND1 1.13646121619622 1.49823237535933e-14 -0.0109881197784345 0.959465409721582 mirMAP -0.221180507811752 0.000359772635429063 NA NA NA hsa-miR-9-5p CCND1 1.65694862043766 2.08325802567323e-05 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.135043708232949 1.13694784335034e-08 NA NA NA hsa-miR-92a-3p CCND1 0.994679542307232 1.32587679156217e-16 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.235491439560111 0.00199944237198536 NA NA NA hsa-miR-93-5p CCND1 1.61042951896619 5.1280369606967e-24 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;MirTarget;miRNATAP -0.120059501509574 0.0337471079428238 NA NA NA hsa-miR-942-5p CCND1 0.678652135586536 2.58063518495056e-07 -0.0109881197784345 0.959465409721582 MirTarget -0.230928848103094 0.0011113987419772 NA NA NA hsa-miR-15b-5p CCND2 0.85315666454713 3.79816274836297e-12 0.148711904010299 0.532420631377314 miRNATAP -0.210665392155605 0.0112338053901537 NA NA NA hsa-miR-224-3p CCND2 0.502645536188015 0.0081142387260641 0.148711904010299 0.532420631377314 mirMAP -0.312870902501466 8.12446049333883e-09 NA NA NA hsa-miR-429 CCND2 0.559451508722375 0.00563641638673083 0.148711904010299 0.532420631377314 miRNATAP -0.121914638155183 0.0173488264276512 NA NA NA hsa-miR-93-5p CCND2 1.61042951896619 5.1280369606967e-24 0.148711904010299 0.532420631377314 miRNATAP -0.125461177225382 0.0441531568104119 NA NA NA hsa-miR-27b-3p CCND3 -0.732682718863563 2.26896143573324e-09 -0.048043868607146 0.631560985924681 miRNAWalker2_validate -0.132150579088403 0.000160876577060277 NA NA NA hsa-miR-107 CCNE1 -0.0447040564279497 0.671618791096755 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.119335632523562 0.0483447408149609 NA NA NA hsa-miR-125b-5p CCNE1 -0.993460109818276 5.07736727659894e-12 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.277374392819013 5.31956215938705e-11 NA NA NA hsa-miR-151a-3p CCNE1 0.131002217498676 0.295273522160941 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.150265962772684 0.00298585050443392 NA NA NA hsa-miR-195-5p CCNE1 -1.8367376818177 6.9944883988895e-31 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.309888398159948 1.15906313064363e-17 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-215-5p CCNE1 -0.757663683237828 5.72998183244808e-05 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.129994430039298 9.70603819621136e-05 NA NA NA hsa-miR-26a-5p CCNE1 -1.09269574587169 1.24020612216319e-22 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.491075252836977 6.85651906736478e-21 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.966244470847844 5.26505649147857e-12 1.47144541933057 8.39227402888879e-27 MirTarget;miRNATAP -0.164722219234429 0.000184434596017171 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-30a-5p CCNE2 -1.79779915425811 1.93360169837799e-26 1.23951713462192 5.15429419774609e-15 miRNATAP -0.160843483864371 5.22163952330061e-05 NA NA NA hsa-miR-369-3p CCNE2 -1.2344419076994 2.66882944171146e-10 1.23951713462192 5.15429419774609e-15 PITA -0.244374203286038 3.35442431580483e-12 NA NA NA hsa-miR-21-5p CCNG1 1.62465922021121 3.44191300985109e-58 -1.01914097071318 1.52561597617797e-21 miRNAWalker2_validate -0.333559537515227 1.68430615205965e-15 NA NA NA hsa-miR-23a-3p CCNG1 0.348231698801568 6.4911858506572e-05 -1.01914097071318 1.52561597617797e-21 MirTarget;miRNATAP -0.275527622229945 7.11832245221205e-07 NA NA NA hsa-miR-24-3p CCNG1 0.13115428390042 0.203891651275156 -1.01914097071318 1.52561597617797e-21 miRNAWalker2_validate -0.163045083676421 0.000569245471517724 NA NA NA hsa-miR-27a-3p CCNG1 0.348456440505425 0.00126682892514312 -1.01914097071318 1.52561597617797e-21 MirTarget;miRNATAP -0.257936423007813 6.66978918562919e-09 NA NA NA hsa-miR-361-5p CCNG1 0.0803683277369505 0.314043140368058 -1.01914097071318 1.52561597617797e-21 miRanda -0.192000608501525 0.00188550110096436 NA NA NA hsa-miR-96-5p CCNG1 1.42326703011157 4.39736150032373e-14 -1.01914097071318 1.52561597617797e-21 MirTarget;TargetScan -0.149208308433956 1.60635659171162e-09 NA NA NA hsa-let-7a-3p CCNG2 0.0966652362351867 0.423761916840503 -1.02144511060822 3.87201711287946e-15 MirTarget;mirMAP -0.118468734212471 0.0146017532563259 NA NA NA hsa-miR-146b-5p CCNG2 0.917975986853978 3.33749259316025e-09 -1.02144511060822 3.87201711287946e-15 miRNATAP -0.119791443369878 0.00118509393968216 NA NA NA hsa-miR-16-2-3p CCNG2 1.1567130855258 1.01867256952189e-14 -1.02144511060822 3.87201711287946e-15 mirMAP -0.118189763787161 0.00183770397596699 NA NA NA hsa-miR-17-5p CCNG2 1.41924888736771 2.75805544953758e-18 -1.02144511060822 3.87201711287946e-15 MirTarget;TargetScan;miRNATAP -0.166524699758166 1.23363568806553e-06 NA NA NA hsa-miR-181a-5p CCNG2 0.819060835827404 1.38616688310277e-13 -1.02144511060822 3.87201711287946e-15 mirMAP -0.116411250669286 0.0243495912919426 NA NA NA hsa-miR-181b-5p CCNG2 0.974255518824355 2.64876280203475e-16 -1.02144511060822 3.87201711287946e-15 mirMAP -0.173807068392077 0.000259183400790311 NA NA NA hsa-miR-20a-5p CCNG2 1.1531986665452 1.02385132917958e-11 -1.02144511060822 3.87201711287946e-15 MirTarget;miRNATAP -0.147542167159351 1.04814360501382e-05 NA NA NA hsa-miR-21-5p CCNG2 1.62465922021121 3.44191300985109e-58 -1.02144511060822 3.87201711287946e-15 mirMAP -0.325894312246883 1.41761237412582e-10 NA NA NA hsa-miR-224-5p CCNG2 1.94534596857416 1.88348779207332e-19 -1.02144511060822 3.87201711287946e-15 mirMAP -0.132590255498133 2.63473494928453e-07 NA NA NA hsa-miR-331-5p CCNG2 0.851618030062133 1.42670149420057e-14 -1.02144511060822 3.87201711287946e-15 miRNATAP -0.13474007214555 0.00897419740879736 NA NA NA hsa-miR-365a-3p CCNG2 0.446833934952926 0.00233857759218299 -1.02144511060822 3.87201711287946e-15 MirTarget -0.11942218905551 0.00255816372342125 NA NA NA hsa-miR-485-3p CCNG2 0.359155046663542 0.0929405338270575 -1.02144511060822 3.87201711287946e-15 MirTarget;mirMAP -0.105396188060574 0.000110148033124434 NA NA NA hsa-miR-493-5p CCNG2 -0.471586962917071 0.0221327433064002 -1.02144511060822 3.87201711287946e-15 MirTarget;miRNATAP -0.10341852067461 0.000241798789527104 NA NA NA hsa-miR-503-5p CCNG2 2.85210590411715 1.27298190263569e-35 -1.02144511060822 3.87201711287946e-15 miRNAWalker2_validate -0.123369942307466 5.43785495985183e-07 NA NA NA hsa-miR-542-3p CCNG2 0.643308814904977 8.81635403230104e-07 -1.02144511060822 3.87201711287946e-15 miRanda;miRNATAP -0.162822962802516 0.000220846756813977 NA NA NA hsa-miR-576-5p CCNG2 0.940432050128373 6.90227595663302e-12 -1.02144511060822 3.87201711287946e-15 mirMAP -0.131591578504679 0.00158540155316213 NA NA NA hsa-miR-590-5p CCNG2 0.763025362395968 3.65305892505623e-09 -1.02144511060822 3.87201711287946e-15 mirMAP -0.148692148223222 0.000817114437293401 NA NA NA hsa-miR-664a-3p CCNG2 -0.256108763664991 0.0513188660751664 -1.02144511060822 3.87201711287946e-15 MirTarget;mirMAP -0.132399113864809 0.00287457412507839 NA NA NA hsa-miR-7-1-3p CCNG2 1.13646121619622 1.49823237535933e-14 -1.02144511060822 3.87201711287946e-15 MirTarget -0.125158759158852 0.00110688377081487 NA NA NA hsa-miR-708-3p CCNG2 1.32647174389322 4.87465491977979e-16 -1.02144511060822 3.87201711287946e-15 MirTarget -0.161846832856879 2.48161565138737e-06 NA NA NA hsa-miR-769-3p CCNG2 0.89886491506181 2.21711828717073e-08 -1.02144511060822 3.87201711287946e-15 miRNATAP -0.1401540168002 9.68885833145098e-05 NA NA NA hsa-miR-93-5p CCNG2 1.61042951896619 5.1280369606967e-24 -1.02144511060822 3.87201711287946e-15 miRNAWalker2_validate;MirTarget;miRNATAP -0.1791727922722 2.23334493053793e-07 NA NA NA hsa-miR-944 CCNG2 1.47323925060177 2.61626403984929e-13 -1.02144511060822 3.87201711287946e-15 mirMAP -0.132944786835073 2.05011376879037e-06 NA NA NA hsa-miR-96-5p CCNG2 1.42326703011157 4.39736150032373e-14 -1.02144511060822 3.87201711287946e-15 MirTarget;TargetScan;miRNATAP -0.119045309341822 7.14551215360663e-05 NA NA NA hsa-miR-491-5p CD82 -0.541680329196715 0.00135829217561865 -0.154820544390334 0.248710667217009 miRanda -0.151611321093834 2.41542872681291e-05 NA NA NA hsa-miR-10b-5p CDK2 -0.582989331935508 4.56688330655626e-06 0.825648307855554 1.29874808659333e-17 miRNAWalker2_validate -0.159909593508401 2.19683871071865e-06 NA NA NA hsa-miR-495-3p CDK2 -1.47803501311999 6.88839745293927e-13 0.825648307855554 1.29874808659333e-17 mirMAP -0.121067515894841 3.00810482531006e-09 NA NA NA hsa-miR-101-3p CDK6 -1.91263766544878 1.50270129259053e-39 0.943799976100438 3.26010908820164e-07 mirMAP -0.330251321821837 9.84955273894382e-11 NA NA NA hsa-miR-106a-5p CDK6 0.67978010057847 0.00221925869726092 0.943799976100438 3.26010908820164e-07 mirMAP -0.270806778075969 3.01546103688573e-14 NA NA NA hsa-miR-140-3p CDK6 -0.967453553824782 7.6999446305445e-23 0.943799976100438 3.26010908820164e-07 miRNATAP -0.274830984983389 0.000572898612660903 NA NA NA hsa-miR-141-3p CDK6 0.730011517758706 0.000120338355004032 0.943799976100438 3.26010908820164e-07 TargetScan;miRNATAP -0.144552658761934 0.000685853549803452 NA NA NA hsa-miR-142-5p CDK6 0.288897753038094 0.0900009317815725 0.943799976100438 3.26010908820164e-07 PITA -0.139817988293101 0.00345142119103429 NA NA NA hsa-miR-146a-5p CDK6 -0.0201236699646614 0.905882759106561 0.943799976100438 3.26010908820164e-07 mirMAP -0.215910726342031 5.89162734992982e-06 NA NA NA hsa-miR-148a-3p CDK6 -0.428944290834563 0.00954246923521465 0.943799976100438 3.26010908820164e-07 mirMAP -0.352194126420792 2.47922792703682e-13 NA NA NA hsa-miR-148a-5p CDK6 -1.00478606532747 1.38045244999229e-07 0.943799976100438 3.26010908820164e-07 mirMAP -0.168311831982054 6.19585640247235e-05 NA NA NA hsa-miR-148b-3p CDK6 0.386859166050437 4.6728211830726e-06 0.943799976100438 3.26010908820164e-07 mirMAP -0.230655591303551 0.0174649784492903 NA NA NA hsa-miR-15a-5p CDK6 0.783550182002274 2.60699595655907e-11 0.943799976100438 3.26010908820164e-07 miRNATAP -0.285921263186907 2.61019491684346e-05 NA NA NA hsa-miR-16-1-3p CDK6 0.955017760172879 5.95379292601146e-11 0.943799976100438 3.26010908820164e-07 mirMAP -0.191844024126834 0.000473356615206941 NA NA NA hsa-miR-16-5p CDK6 0.521122945828175 1.40561786410572e-06 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.390172822616052 1.63474102862122e-07 NA NA NA hsa-miR-191-5p CDK6 0.648528205617075 5.59342922179914e-07 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.304048292825889 9.20052672769938e-07 NA NA NA hsa-miR-195-5p CDK6 -1.8367376818177 6.9944883988895e-31 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.147548431452902 0.00221639504281517 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-200a-3p CDK6 0.607140814457753 0.00289840524858752 0.943799976100438 3.26010908820164e-07 miRNATAP -0.141449889886458 0.00036916846884784 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 0.0717138787925347 0.682858087587209 0.943799976100438 3.26010908820164e-07 mirMAP -0.172143765246203 0.000203839288085545 NA NA NA hsa-miR-20b-5p CDK6 0.345967670847176 0.232014828043601 0.943799976100438 3.26010908820164e-07 mirMAP -0.319548642762033 7.55584014107553e-34 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-217 CDK6 -1.35391381055929 2.42394951427902e-09 0.943799976100438 3.26010908820164e-07 mirMAP -0.101972431424956 0.00385414956789609 NA NA NA hsa-miR-218-5p CDK6 -1.0725338636959 3.61493686604269e-09 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate -0.157173497673979 0.000358234774549337 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC malignant trasformation liver cancer hsa-miR-224-3p CDK6 0.502645536188015 0.0081142387260641 0.943799976100438 3.26010908820164e-07 mirMAP -0.103604720872101 0.0163689617892578 NA NA NA hsa-miR-23b-3p CDK6 -0.497563803223134 3.31483353357535e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.187559518282179 0.00569215928221825 NA NA NA hsa-miR-26a-5p CDK6 -1.09269574587169 1.24020612216319e-22 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.299394118060181 1.85556297732571e-05 26314438 Maxvision immunohistochemistry technique was used to detect the expression level of CDK6 and miR-26a in tissue of 20 ENKTCL cases 10 cases of proliferative lymphadenitis and 10 samples of normal lymph node respectively; The possible role of miR-26a and its target gene CDK6 in genesis and development of ENKTCL were analyzed according to the clinical features of ENKTCL patients; Correlation analysis showed that there was significant negative correlation between miR-26a expression and CDK6 expression r = -0.54 P = 0.04 lymphoma hsa-miR-26b-5p CDK6 -0.254478038884324 0.0285227763044636 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.366507052753924 1.49769255271943e-07 NA NA NA hsa-miR-27b-3p CDK6 -0.732682718863563 2.26896143573324e-09 0.943799976100438 3.26010908820164e-07 mirMAP -0.25498599690856 9.88663275746304e-05 NA NA NA hsa-miR-27b-5p CDK6 0.580870079022649 0.000181529223377382 0.943799976100438 3.26010908820164e-07 mirMAP -0.136352328908371 0.00915378846518187 NA NA NA hsa-miR-29a-3p CDK6 -1.26881270980079 2.82496991513463e-22 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123841351266681 0.0390099642620887 22493297;23245396;20086245 In addition a target of miR-29a cyclin-dependent kinase 6 gene and a target of miR-142-3p TGF-β-activated kinase 1/MAP3K7 binding protein 2 gene are involved in the regulation of both monocytic and granulocytic differentiation;The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL differentiation;; acute myeloid leukemia;melanoma;lymphoma hsa-miR-29b-3p CDK6 -0.110721443686039 0.511264554091106 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231353291571021 1.47948165135711e-06 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -2.08166260448948 8.3238369390898e-24 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.263284323247694 8.29389379067708e-13 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-3p CDK6 -2.26144364746452 8.12421214153823e-31 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;mirMAP -0.140198240628917 0.000324956485864008 NA NA NA hsa-miR-30a-5p CDK6 -1.79779915425811 1.93360169837799e-26 0.943799976100438 3.26010908820164e-07 mirMAP -0.244091558945119 7.330875395431e-08 NA NA NA hsa-miR-30b-5p CDK6 -0.400238605368173 0.00346540992719245 0.943799976100438 3.26010908820164e-07 mirMAP -0.434806721700384 7.69264513504911e-14 NA NA NA hsa-miR-30c-5p CDK6 0.021222006155897 0.886366656528128 0.943799976100438 3.26010908820164e-07 mirMAP -0.3418227405519 2.85445288861842e-10 NA NA NA hsa-miR-30d-3p CDK6 -0.577371911152798 2.02950840095287e-06 0.943799976100438 3.26010908820164e-07 mirMAP -0.503232545055278 1.21266173811556e-14 NA NA NA hsa-miR-30d-5p CDK6 -0.38399848121878 0.000171129616944749 0.943799976100438 3.26010908820164e-07 mirMAP -0.478956981188774 1.25587674803108e-09 NA NA NA hsa-miR-30e-3p CDK6 -0.890635378639789 1.65740480611339e-16 0.943799976100438 3.26010908820164e-07 mirMAP -0.493162425301019 8.88393527920392e-12 NA NA NA hsa-miR-30e-5p CDK6 -1.02114836019762 6.81961221797866e-17 0.943799976100438 3.26010908820164e-07 mirMAP -0.527037067797998 5.6019097407655e-17 NA NA NA hsa-miR-32-5p CDK6 -0.317310201890053 0.0102525324475293 0.943799976100438 3.26010908820164e-07 miRNATAP -0.343788737898722 1.50852274763283e-07 NA NA NA hsa-miR-320a CDK6 0.801356001806321 4.91397101474502e-09 0.943799976100438 3.26010908820164e-07 PITA;miRNATAP -0.215899862858631 0.000228990035954073 NA NA NA hsa-miR-335-3p CDK6 0.336785882180547 0.0542446207938138 0.943799976100438 3.26010908820164e-07 mirMAP -0.134100857118668 0.00395950799932265 NA NA NA hsa-miR-335-5p CDK6 -1.17227779671552 1.49282618530733e-10 0.943799976100438 3.26010908820164e-07 mirMAP -0.17718916608193 4.69104859301016e-05 NA NA NA hsa-miR-340-5p CDK6 -0.608415693437977 4.44345153563513e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.17760804422206 0.00108030432977789 NA NA NA hsa-miR-34a-5p CDK6 -0.117372471043915 0.364001947180738 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.474044531250989 1.69147353058574e-14 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-362-5p CDK6 0.41089772861323 0.0404254902071382 0.943799976100438 3.26010908820164e-07 mirMAP -0.260229145155647 7.00102306080077e-11 NA NA NA hsa-miR-374a-3p CDK6 -0.299190081500425 0.00682975596757891 0.943799976100438 3.26010908820164e-07 mirMAP -0.380845410382319 2.04485987693411e-07 NA NA NA hsa-miR-374a-5p CDK6 -0.621903385111545 6.61791773205282e-12 0.943799976100438 3.26010908820164e-07 mirMAP -0.405061325584562 4.73802604337785e-06 NA NA NA hsa-miR-374b-5p CDK6 -0.288413933608091 0.0041474558664058 0.943799976100438 3.26010908820164e-07 mirMAP -0.474069124376016 3.78110860368437e-09 NA NA NA hsa-miR-378a-3p CDK6 -1.50453783521372 9.41694954361173e-17 0.943799976100438 3.26010908820164e-07 mirMAP -0.209704195412153 1.273508200611e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-429 CDK6 0.559451508722375 0.00563641638673083 0.943799976100438 3.26010908820164e-07 mirMAP;miRNATAP -0.106003536253203 0.0083665250305265 NA NA NA hsa-miR-497-5p CDK6 -0.966244470847844 5.26505649147857e-12 0.943799976100438 3.26010908820164e-07 miRNATAP -0.336887999296509 2.21691851621954e-09 NA NA NA hsa-miR-500a-5p CDK6 0.675401699376111 8.24389004707854e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.136463332134803 0.0038451740739746 NA NA NA hsa-miR-501-3p CDK6 0.820141346319976 1.74562930463389e-08 0.943799976100438 3.26010908820164e-07 PITA;TargetScan;miRNATAP -0.126792914533937 0.0222216417874572 NA NA NA hsa-miR-502-3p CDK6 -0.165138869760313 0.106881047403914 0.943799976100438 3.26010908820164e-07 PITA;miRNATAP -0.296409566969119 0.000210944839114926 NA NA NA hsa-miR-582-5p CDK6 -0.0366995972742474 0.821827119138923 0.943799976100438 3.26010908820164e-07 miRNATAP -0.222480119114911 7.9439037894028e-06 NA NA NA hsa-miR-590-3p CDK6 0.221436901462551 0.0965904764063157 0.943799976100438 3.26010908820164e-07 mirMAP;miRNATAP -0.167194733039206 0.00641945407308449 NA NA NA hsa-miR-660-5p CDK6 -0.202705992887645 0.101093376073573 0.943799976100438 3.26010908820164e-07 mirMAP -0.39601322603476 1.31183015377543e-09 NA NA NA hsa-miR-664a-3p CDK6 -0.256108763664991 0.0513188660751664 0.943799976100438 3.26010908820164e-07 mirMAP -0.32103643789594 1.87674231980515e-07 NA NA NA hsa-miR-7-1-3p CDK6 1.13646121619622 1.49823237535933e-14 0.943799976100438 3.26010908820164e-07 mirMAP -0.167417347789213 0.0018262424002125 NA NA NA hsa-miR-9-5p CDK6 1.65694862043766 2.08325802567323e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.168540643433085 5.15188603206423e-17 NA NA NA hsa-let-7a-5p CDKN1A -0.439381775414001 3.1119785480023e-05 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget;TargetScan -0.157887314863044 0.00607392500892242 NA NA NA hsa-let-7c-5p CDKN1A -2.07953368242668 3.46048888391218e-23 0.127907055720529 0.358633438275103 MirTarget -0.154966489020611 1.40043705353072e-08 NA NA NA hsa-let-7d-5p CDKN1A 0.481757661442508 3.66030810124939e-07 0.127907055720529 0.358633438275103 MirTarget -0.318303233510587 5.28719683231192e-07 NA NA NA hsa-let-7f-5p CDKN1A -0.441845198213823 0.00242957484218694 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget -0.182282405867162 1.04368032915846e-05 NA NA NA hsa-let-7g-5p CDKN1A -0.250780249469264 0.00939610188330072 0.127907055720529 0.358633438275103 MirTarget -0.398859680782031 1.57079778109355e-10 NA NA NA hsa-let-7i-5p CDKN1A 0.249440992451337 0.00426823922424972 0.127907055720529 0.358633438275103 MirTarget -0.294915458886481 2.44467484945999e-05 NA NA NA hsa-miR-101-3p CDKN1A -1.91263766544878 1.50270129259053e-39 0.127907055720529 0.358633438275103 MirTarget -0.258645074781103 9.13055424902711e-12 NA NA NA hsa-miR-106a-5p CDKN1A 0.67978010057847 0.00221925869726092 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127737584115643 2.20859465651693e-06 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 0.50378717276868 1.45412404526866e-05 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.395677807466644 6.77429329572222e-15 NA NA NA hsa-miR-132-3p CDKN1A 0.237841736463996 0.00653466538179383 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.138635683872027 0.0484263223756676 NA NA NA hsa-miR-20b-5p CDKN1A 0.345967670847176 0.232014828043601 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104762985609593 4.52354521296224e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.026996999089909 0.733047113251652 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.739238141393868 4.97263373683604e-23 NA NA NA hsa-miR-30b-3p CDKN1A -0.338530747940815 0.0223424741180399 0.127907055720529 0.358633438275103 MirTarget -0.214381215718527 1.34523563618692e-07 NA NA NA hsa-miR-335-5p CDKN1A -1.17227779671552 1.49282618530733e-10 0.127907055720529 0.358633438275103 miRNAWalker2_validate -0.233668033663431 2.16898184164444e-13 NA NA NA hsa-miR-345-5p CDKN1A 0.882162580294938 2.95895678052434e-07 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget -0.22316248649142 7.71072127808706e-11 NA NA NA hsa-miR-363-3p CDKN1A -0.608157508016978 0.0186109501272176 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.113214661296052 1.07835696522481e-06 NA NA NA hsa-miR-423-5p CDKN1A 0.60141781325829 1.62940950644999e-07 0.127907055720529 0.358633438275103 MirTarget -0.249258805343378 1.73973574563061e-06 NA NA NA hsa-miR-429 CDKN1A 0.559451508722375 0.00563641638673083 0.127907055720529 0.358633438275103 miRNATAP -0.109329855441573 0.000248387440193944 NA NA NA hsa-miR-491-5p CDKN1A -0.541680329196715 0.00135829217561865 0.127907055720529 0.358633438275103 miRanda -0.113024010321719 0.00252753472048722 NA NA NA hsa-miR-582-5p CDKN1A -0.0366995972742474 0.821827119138923 0.127907055720529 0.358633438275103 miRNATAP -0.162063113723445 1.25361670221294e-05 NA NA NA hsa-miR-654-3p CDKN1A -1.77960431554497 1.76486415439529e-14 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.117614114313009 3.17265104059811e-06 NA NA NA hsa-miR-93-5p CDKN1A 1.61042951896619 5.1280369606967e-24 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131898490796649 0.000276995054107702 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-98-5p CDKN1A 0.0176698653376732 0.858271091070735 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget -0.236406574284277 0.000129077758881236 NA NA NA hsa-miR-139-5p CHEK1 -1.46099200329485 7.85040381494472e-22 1.20396859855604 7.17975286300605e-27 miRanda -0.178007141307805 3.06480379143231e-08 NA NA NA hsa-miR-195-5p CHEK1 -1.8367376818177 6.9944883988895e-31 1.20396859855604 7.17975286300605e-27 MirTarget;miRNATAP -0.174259778110084 7.35654556791948e-09 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-495-3p CHEK1 -1.47803501311999 6.88839745293927e-13 1.20396859855604 7.17975286300605e-27 MirTarget -0.100625603739772 3.70483806389657e-05 NA NA NA hsa-miR-497-5p CHEK1 -0.966244470847844 5.26505649147857e-12 1.20396859855604 7.17975286300605e-27 MirTarget;miRNATAP -0.141727865552293 8.05919355042318e-05 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-125a-3p CYCS 0.116035800853173 0.444825559956959 -0.134141810341233 0.133947101630507 miRanda -0.107410555046087 2.65589206099304e-05 NA NA NA hsa-miR-361-5p FAS 0.0803683277369505 0.314043140368058 -0.353746390296431 0.0224836395610983 miRanda -0.254638067114056 0.00313062697979385 NA NA NA hsa-miR-590-5p FAS 0.763025362395968 3.65305892505623e-09 -0.353746390296431 0.0224836395610983 miRanda -0.179002441556527 0.000520949899474374 NA NA NA hsa-miR-98-5p FAS 0.0176698653376732 0.858271091070735 -0.353746390296431 0.0224836395610983 miRNAWalker2_validate -0.14040192647554 0.0424993258234579 NA NA NA hsa-miR-148a-3p GADD45A -0.428944290834563 0.00954246923521465 -0.148778543104967 0.244563831657349 MirTarget;miRNATAP -0.115529771802971 0.000569454583886927 NA NA NA hsa-miR-148b-3p GADD45A 0.386859166050437 4.6728211830726e-06 -0.148778543104967 0.244563831657349 MirTarget -0.297536185776573 6.20121677211309e-06 NA NA NA hsa-miR-152-3p GADD45A -0.382486223604156 0.00710736505198702 -0.148778543104967 0.244563831657349 MirTarget -0.124908349912319 0.00141434525214503 NA NA NA hsa-miR-1976 GADD45B 0.638808083289405 2.94840228896364e-07 -1.29500058031274 1.88372965534317e-17 miRNATAP -0.163735681565526 0.00273735021269302 NA NA NA hsa-miR-324-3p GADD45B 0.867391246413545 3.63808540490361e-10 -1.29500058031274 1.88372965534317e-17 MirTarget;miRNATAP -0.456604551243598 2.13998090154516e-22 NA NA NA hsa-miR-590-3p GADD45B 0.221436901462551 0.0965904764063157 -1.29500058031274 1.88372965534317e-17 miRanda -0.163308519334935 0.00155213230880389 NA NA NA hsa-miR-107 GADD45G -0.0447040564279497 0.671618791096755 -1.08524974570121 1.91330427119552e-06 miRanda -0.261360902067525 0.00649010053220016 NA NA NA hsa-miR-296-5p GADD45G -0.425442682383961 0.0948240114267711 -1.08524974570121 1.91330427119552e-06 miRNATAP -0.100896610505165 0.0123096949032642 NA NA NA hsa-miR-320b GADD45G 1.23473838180754 3.04337566045537e-14 -1.08524974570121 1.91330427119552e-06 miRanda -0.177971631376559 0.00309864212413347 NA NA NA hsa-miR-421 GADD45G 0.945488088619653 2.35762398527362e-09 -1.08524974570121 1.91330427119552e-06 miRanda -0.165999925954088 0.00807659341669784 NA NA NA hsa-miR-429 GADD45G 0.559451508722375 0.00563641638673083 -1.08524974570121 1.91330427119552e-06 miRNATAP -0.11150368629514 0.0244457804105109 NA NA NA hsa-miR-139-5p GTSE1 -1.46099200329485 7.85040381494472e-22 1.91479773038689 3.17305633688938e-41 miRanda -0.300852352003789 5.05570167502871e-13 NA NA NA hsa-miR-338-3p GTSE1 -0.948755228846395 8.99167125682392e-08 1.91479773038689 3.17305633688938e-41 miRanda -0.170930216372992 4.54954364637476e-06 NA NA NA hsa-let-7a-3p IGF1 0.0966652362351867 0.423761916840503 -1.83606554417213 4.89445874007951e-10 mirMAP -0.628414381189287 5.27761426031282e-09 NA NA NA hsa-let-7f-1-3p IGF1 0.700374242293247 8.65000484720084e-08 -1.83606554417213 4.89445874007951e-10 mirMAP -0.223014721795587 0.0247561439527582 NA NA NA hsa-miR-103a-2-5p IGF1 1.37988337975616 6.74852943995612e-08 -1.83606554417213 4.89445874007951e-10 mirMAP -0.45438875584609 1.7540230331713e-17 NA NA NA hsa-miR-130a-3p IGF1 0.67051191119964 4.89747518735144e-06 -1.83606554417213 4.89445874007951e-10 MirTarget -0.700417159997035 4.55001564446877e-16 NA NA NA hsa-miR-130b-3p IGF1 1.44628430084411 9.13980959861273e-24 -1.83606554417213 4.89445874007951e-10 MirTarget -0.381225145442848 1.06880616791146e-05 NA NA NA hsa-miR-15b-3p IGF1 1.05020782493504 6.38723677324836e-14 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600110692355124 2.35788363622271e-11 NA NA NA hsa-miR-16-1-3p IGF1 0.955017760172879 5.95379292601146e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.654262965462375 3.52738431783344e-14 NA NA NA hsa-miR-186-5p IGF1 0.353452958261612 0.000145058448579496 -1.83606554417213 4.89445874007951e-10 mirMAP -0.366692143669484 0.00959838552779203 NA NA NA hsa-miR-19a-3p IGF1 1.35800152353624 2.80940447111944e-12 -1.83606554417213 4.89445874007951e-10 MirTarget -0.675360942734142 3.91550460498543e-27 NA NA NA hsa-miR-19b-1-5p IGF1 0.757034032029085 2.99828133413343e-07 -1.83606554417213 4.89445874007951e-10 mirMAP -0.699245326551041 2.59396405008731e-16 NA NA NA hsa-miR-19b-3p IGF1 0.538732279378089 0.000622008277870679 -1.83606554417213 4.89445874007951e-10 MirTarget -0.750279055807441 5.4834038782256e-21 NA NA NA hsa-miR-205-3p IGF1 1.2960640797621 5.80786479909147e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600295652502196 5.84026535331867e-22 NA NA NA hsa-miR-20a-3p IGF1 1.34885093664027 2.07697464119202e-12 -1.83606554417213 4.89445874007951e-10 mirMAP -0.573755673684406 5.83753051386334e-19 NA NA NA hsa-miR-224-3p IGF1 0.502645536188015 0.0081142387260641 -1.83606554417213 4.89445874007951e-10 mirMAP -0.397083320323672 6.59448390538765e-09 NA NA NA hsa-miR-27a-3p IGF1 0.348456440505425 0.00126682892514312 -1.83606554417213 4.89445874007951e-10 miRNAWalker2_validate;miRTarBase -0.630796790452773 1.61575924809895e-07 NA NA NA hsa-miR-28-3p IGF1 0.459875450032895 3.47095927872566e-07 -1.83606554417213 4.89445874007951e-10 MirTarget -0.297876747247095 0.0405591423170885 NA NA NA hsa-miR-301a-3p IGF1 2.14132004241926 4.46255413526808e-25 -1.83606554417213 4.89445874007951e-10 MirTarget -0.542962161756586 7.28279283702467e-21 NA NA NA hsa-miR-320a IGF1 0.801356001806321 4.91397101474502e-09 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.471166482627833 4.87790750232857e-07 NA NA NA hsa-miR-320b IGF1 1.23473838180754 3.04337566045537e-14 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.435970586012069 1.99260325159595e-08 NA NA NA hsa-miR-33a-3p IGF1 0.20371038027126 0.212335697664505 -1.83606554417213 4.89445874007951e-10 MirTarget -0.301086727433913 0.000210494168325812 NA NA NA hsa-miR-34b-3p IGF1 1.05595687443274 4.36830248743191e-05 -1.83606554417213 4.89445874007951e-10 mirMAP -0.12750718956527 0.0131037797382625 NA NA NA hsa-miR-3607-3p IGF1 1.01377165357363 9.13355519701165e-05 -1.83606554417213 4.89445874007951e-10 mirMAP -0.279152595145872 1.84181237021726e-08 NA NA NA hsa-miR-362-5p IGF1 0.41089772861323 0.0404254902071382 -1.83606554417213 4.89445874007951e-10 mirMAP -0.266319117984938 4.10437106471054e-05 NA NA NA hsa-miR-450b-5p IGF1 1.25529820885833 1.18847120528666e-15 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;mirMAP;miRNATAP -0.248366118573042 0.00221127559765416 NA NA NA hsa-miR-452-5p IGF1 0.373288744398455 0.0348485937209964 -1.83606554417213 4.89445874007951e-10 MirTarget;mirMAP -0.266246297258034 0.000308015705405959 NA NA NA hsa-miR-454-3p IGF1 1.54137391927201 4.15861570449376e-20 -1.83606554417213 4.89445874007951e-10 MirTarget -0.626033221014056 8.04576753877952e-18 NA NA NA hsa-miR-576-5p IGF1 0.940432050128373 6.90227595663302e-12 -1.83606554417213 4.89445874007951e-10 PITA;mirMAP;miRNATAP -0.73695380930135 6.7749669820951e-16 NA NA NA hsa-miR-590-3p IGF1 0.221436901462551 0.0965904764063157 -1.83606554417213 4.89445874007951e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.293536383987437 0.00288981376091861 NA NA NA hsa-miR-629-5p IGF1 0.461215538037447 8.95262667860215e-06 -1.83606554417213 4.89445874007951e-10 mirMAP -0.473288980212107 0.00016595454212857 NA NA NA hsa-miR-940 IGF1 1.25303020594374 1.3005368359451e-10 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;miRNATAP -0.179832112337034 0.00706374566547861 NA NA NA hsa-let-7a-3p IGFBP3 0.0966652362351867 0.423761916840503 1.31162008873232 3.37696142113191e-08 miRNATAP -0.240591190921702 0.00591660569748922 NA NA NA hsa-miR-19a-3p IGFBP3 1.35800152353624 2.80940447111944e-12 1.31162008873232 3.37696142113191e-08 MirTarget;miRNATAP -0.113859640609741 0.0313981852459747 NA NA NA hsa-miR-19b-3p IGFBP3 0.538732279378089 0.000622008277870679 1.31162008873232 3.37696142113191e-08 MirTarget;miRNATAP -0.254437784731586 0.000123320743810695 NA NA NA hsa-miR-34a-5p IGFBP3 -0.117372471043915 0.364001947180738 1.31162008873232 3.37696142113191e-08 miRNATAP -0.358491037451918 9.9388240308686e-06 NA NA NA hsa-miR-590-3p IGFBP3 0.221436901462551 0.0965904764063157 1.31162008873232 3.37696142113191e-08 miRanda -0.182907294682777 0.0208279811247891 NA NA NA hsa-miR-145-5p MDM2 -0.46917511594055 0.000685297625493134 -0.187608646962063 0.0757851997933277 miRNAWalker2_validate -0.120282167205982 0.000285646785971262 NA NA NA hsa-miR-181a-2-3p MDM2 0.562132917934234 4.79313448225408e-05 -0.187608646962063 0.0757851997933277 mirMAP -0.183010150101776 2.34295977089442e-08 NA NA NA hsa-miR-450a-5p MDM2 1.74695686398479 4.62583996044297e-22 -0.187608646962063 0.0757851997933277 mirMAP -0.133291140860781 3.19028333188365e-08 NA NA NA hsa-let-7a-5p MDM4 -0.439381775414001 3.1119785480023e-05 0.0883527290518815 0.371792607992624 MirTarget;TargetScan -0.161157649624351 7.30585782392489e-05 NA NA NA hsa-let-7b-5p MDM4 -0.2489842756826 0.0211384499461719 0.0883527290518815 0.371792607992624 miRNAWalker2_validate;MirTarget -0.166166365113163 3.07710722572198e-05 NA NA NA hsa-let-7e-5p MDM4 0.0857356192778891 0.512869729833211 0.0883527290518815 0.371792607992624 MirTarget -0.182087564213607 2.35061495285714e-08 NA NA NA hsa-miR-125a-3p MDM4 0.116035800853173 0.444825559956959 0.0883527290518815 0.371792607992624 miRanda -0.144717901413484 2.70533462305936e-07 NA NA NA hsa-miR-125a-3p PERP 0.116035800853173 0.444825559956959 0.0402086313936358 0.800945857114924 miRanda -0.119968380376055 0.00889552255550686 NA NA NA hsa-miR-127-5p PERP -0.605739525751187 0.000636065602565634 0.0402086313936358 0.800945857114924 MirTarget -0.125959214859642 0.00121732800532189 NA NA NA hsa-miR-146b-5p PERP 0.917975986853978 3.33749259316025e-09 0.0402086313936358 0.800945857114924 miRanda -0.181286643420007 3.65584260250354e-05 NA NA NA hsa-miR-192-5p PERP 0.380924502586635 0.00986961967409205 0.0402086313936358 0.800945857114924 miRNAWalker2_validate -0.240635672315048 2.43659170425863e-07 NA NA NA hsa-miR-215-5p PERP -0.757663683237828 5.72998183244808e-05 0.0402086313936358 0.800945857114924 miRNAWalker2_validate -0.139789695189868 0.000141491306326441 NA NA NA hsa-miR-218-5p PERP -1.0725338636959 3.61493686604269e-09 0.0402086313936358 0.800945857114924 MirTarget -0.273597304655557 1.01417119159749e-13 NA NA NA hsa-miR-361-5p PERP 0.0803683277369505 0.314043140368058 0.0402086313936358 0.800945857114924 miRanda -0.26168692670671 0.00309258994006191 NA NA NA hsa-miR-582-5p PERP -0.0366995972742474 0.821827119138923 0.0402086313936358 0.800945857114924 miRNATAP -0.261120773108593 5.43120512201213e-10 NA NA NA hsa-miR-22-3p PMAIP1 0.00776313533473072 0.926356548861307 0.413050918008753 0.00858326872074618 MirTarget -0.24217477864098 0.00352585298851185 NA NA NA hsa-miR-370-3p PMAIP1 -0.362239506850908 0.0857012995712968 0.413050918008753 0.00858326872074618 MirTarget -0.124338789112375 0.000133841766924475 NA NA NA hsa-miR-98-5p PMAIP1 0.0176698653376732 0.858271091070735 0.413050918008753 0.00858326872074618 miRNAWalker2_validate -0.168304028635944 0.0164705038849048 NA NA NA hsa-let-7a-3p PPM1D 0.0966652362351867 0.423761916840503 -0.402133074939072 1.86435694952019e-05 MirTarget -0.192840412608173 1.24138918364151e-08 NA NA NA hsa-miR-125a-5p PPM1D 0.215366061934933 0.119550904549401 -0.402133074939072 1.86435694952019e-05 miRanda -0.149022240233314 4.76293586636566e-07 NA NA NA hsa-miR-148b-5p PPM1D 1.1533193737265 7.26420964688337e-13 -0.402133074939072 1.86435694952019e-05 MirTarget -0.1037897626626 3.96260902578162e-05 NA NA NA hsa-miR-15a-5p PPM1D 0.783550182002274 2.60699595655907e-11 -0.402133074939072 1.86435694952019e-05 MirTarget;miRNATAP -0.154748485686335 6.49548664761943e-06 NA NA NA hsa-miR-29a-5p PPM1D 0.323252792625584 0.0370417231222825 -0.402133074939072 1.86435694952019e-05 MirTarget -0.145593673706258 3.04215322253102e-08 NA NA NA hsa-miR-424-5p PPM1D 1.48125289532143 9.10372985713165e-19 -0.402133074939072 1.86435694952019e-05 MirTarget;miRNATAP -0.13598998835342 6.64052027161056e-09 NA NA NA hsa-miR-103a-3p PTEN 0.556219385347418 1.55815736455067e-09 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase -0.212301381039792 1.12994240930338e-06 26511107;24828205 LncRNA GAS5 induces PTEN expression through inhibiting miR 103 in endometrial cancer cells; To investigate the expression of GAS5 PTEN and miR-103 RT-PCR was performed; Finally we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells; Through inhibiting the expression of miR-103 GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis and thus could be an important mediator in the pathogenesis of endometrial cancer;Our data collectively demonstrate that miR-103 is an oncogene miRNA that promotes colorectal cancer proliferation and migration through down-regulation of the tumor suppressor genes DICER and PTEN ; endometrial cancer;colorectal cancer hsa-miR-106a-5p PTEN 0.67978010057847 0.00221925869726092 -0.105559265617794 0.259478904420102 miRNATAP -0.106146372576128 3.66470578195619e-09 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-106b-5p PTEN 0.50378717276868 1.45412404526866e-05 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174826094407509 4.51369872456834e-07 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-130b-3p PTEN 1.44628430084411 9.13980959861273e-24 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.12763831354529 2.02162718248739e-06 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-141-3p PTEN 0.730011517758706 0.000120338355004032 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.125754501440233 2.19301445533495e-09 27644195;24742567 Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis drug resistance;tumorigenesis esophageal cancer;endometrial cancer hsa-miR-148b-3p PTEN 0.386859166050437 4.6728211830726e-06 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.117668874173982 0.015177793520145 NA NA NA hsa-miR-15b-3p PTEN 1.05020782493504 6.38723677324836e-14 -0.105559265617794 0.259478904420102 mirMAP -0.149806075215585 9.98966845863658e-08 NA NA NA hsa-miR-16-1-3p PTEN 0.955017760172879 5.95379292601146e-11 -0.105559265617794 0.259478904420102 MirTarget -0.101536030757984 0.000209771919825589 NA NA NA hsa-miR-16-2-3p PTEN 1.1567130855258 1.01867256952189e-14 -0.105559265617794 0.259478904420102 mirMAP -0.140201599486745 9.49304636851156e-08 NA NA NA hsa-miR-17-5p PTEN 1.41924888736771 2.75805544953758e-18 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.140106850111196 4.3473859521156e-09 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-182-5p PTEN 1.15060905311096 6.25565852529946e-10 -0.105559265617794 0.259478904420102 mirMAP -0.129020080970652 1.15688418944506e-09 NA NA NA hsa-miR-186-5p PTEN 0.353452958261612 0.000145058448579496 -0.105559265617794 0.259478904420102 mirMAP;miRNATAP -0.157331259101545 0.000334733432007599 NA NA NA hsa-miR-188-5p PTEN 0.559328953885106 0.000430338888594543 -0.105559265617794 0.259478904420102 MirTarget;PITA;miRNATAP -0.116715312390083 4.58343088299575e-06 NA NA NA hsa-miR-19b-3p PTEN 0.538732279378089 0.000622008277870679 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.141954274984075 2.53034214678501e-08 26098000;24831732;21853360;24681249 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN ;;drug resistance;metastasis lung cancer;breast cancer;breast cancer;colon cancer hsa-miR-200a-3p PTEN 0.607140814457753 0.00289840524858752 -0.105559265617794 0.259478904420102 miRNATAP -0.148111731349853 2.35958613974647e-14 22637745;24742567;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ;tumorigenesis; pancreatic cancer;endometrial cancer;pancreatic cancer hsa-miR-200b-3p PTEN 0.0717138787925347 0.682858087587209 -0.105559265617794 0.259478904420102 TargetScan;mirMAP -0.171021772729679 4.66573539439015e-14 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-200c-3p PTEN 0.630251054099546 0.000131975031451555 -0.105559265617794 0.259478904420102 mirMAP;miRNATAP -0.11197157521581 4.46533092344619e-06 24682933;22637745 In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment metastasis;poor survival; colon cancer;pancreatic cancer hsa-miR-20a-5p PTEN 1.1531986665452 1.02385132917958e-11 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.146702630345827 2.40532820370931e-10 26031366 The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction; MiR-20a levels were increased in HCC cell lines and tissues whereas PTEN was inversely correlated with it; PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance drug resistance liver cancer hsa-miR-20b-5p PTEN 0.345967670847176 0.232014828043601 -0.105559265617794 0.259478904420102 miRNATAP -0.100046689111042 3.39404588539732e-13 23945289;24468585;27701465;25364498 In vitro RNA-pull down assays indicated that miR-20b targets numerous tumor suppressors including PTEN and BRCA1 which were downregulated in HCC1806; Conversely suppression of miR-20b increased PTEN and BRCA1 levels;Finally the impact of these up-regulated miRNAs on PTEN expression was tested by using dual-luciferase reporter assay system from which the results indicated that miR-20b -21 and -130b were involved in suppression of PTEN expression; These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer;Additionally the 3'-untranslated region 3'-UTR of phosphatase and tensin homologue PTEN binding with miR-20b was analyzed by dual-luciferase reporter assays; The results indicated that miR-20b expression level in esophageal tumor tissues was significantly increased compared with their neighboring normal tissues but its expression was inverse with PTEN protein expression; Luciferase assays confirmed that the 3'-UTR of PTEN was a target of miR-20b in esophageal cancer cells; MiR-20b upregulation promoted cell proliferation migration invasiveness and tumor growth and decreased apoptosis and reduced PTEN protein level but not mRNA expression in Eca-109 cells; Conversely downregulation of miR-20b suppressed these processes in KYSE-150 cells and enhanced PTEN protein expression; These data indicate that miR-20b plays important roles in tumorigenesis of esophageal cancer possibly via regulation of PTEN expression and it may be a potential therapeutic target for esophageal cancer treatment;MicroRNA 20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue PTEN; We identified PTEN a well-known tumor suppressor as the functional downstream target of miR-20b; Luciferase assays confirmed that miR-20b could directly bind to the 3' untranslated regionUTR of PTEN and suppress translation; Alteration of miR-20b expression changed PTEN protein level but not mRNA expression in ZR-75-30 and MCF-7 breast cancer cells suggesting miR-20b regulates PTEN gene expression at the posttranscriptional level; Dysregulation of miR-20b plays critical roles in the breast cancer tumorigenesis at least in part via targeting the tumor suppressor PTEN ;;tumorigenesis;tumorigenesis breast cancer;colorectal cancer;esophageal cancer;breast cancer hsa-miR-25-3p PTEN 0.76549796417801 3.32282098247097e-11 -0.105559265617794 0.259478904420102 miRTarBase;MirTarget;miRNATAP -0.2479570822814 3.10997599301382e-13 NA NA NA hsa-miR-26b-5p PTEN -0.254478038884324 0.0285227763044636 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.119107310036174 0.000693884471580411 26068649 Down regulation of microRNA 26b modulates non small cell lung cancer cells chemoresistance and migration through the association of PTEN; It indicates that miR-26b may regulate NSCLC migration and chemosensitivity through the regulation of PTEN drug resistance lung squamous cell cancer hsa-miR-28-5p PTEN -0.026996999089909 0.733047113251652 -0.105559265617794 0.259478904420102 miRanda -0.148078581199056 0.00466758423516303 NA NA NA hsa-miR-29b-3p PTEN -0.110721443686039 0.511264554091106 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104140290718439 1.49268174826838e-05 26471361;23179556;26063204;21359530 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Anticancer role of MUC1 aptamer miR 29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation; Our study indicated that Chi-29b chimera can effectively exert antitumor effect through specific delivery of miR-29b into OVCAR-3 tumor cells subsequently reexpressing PTEN gene and inducing cell apoptosis;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA;In contrast enhanced miR-29b expression by transfection with pre-miR-29b decreased the expression of PTEN and impaired apoptosis increasing tumor cell migration and invasion; Moreover PTEN was shown to be a direct target of miR-29b and was also shown to contribute to the miR-29b-mediated effects on cell invasion; Modulation of miR-29b altered the role of PTEN involved in cell migration and invasion; Aberrant expression of miR-29b which modulates PTEN expression can contribute to migration invasion and anti-apoptosis ;;;cell migration bladder cancer;ovarian cancer;lung squamous cell cancer;breast cancer hsa-miR-30b-5p PTEN -0.400238605368173 0.00346540992719245 -0.105559265617794 0.259478904420102 mirMAP -0.167292628386744 1.22945082617617e-08 NA NA NA hsa-miR-30c-5p PTEN 0.021222006155897 0.886366656528128 -0.105559265617794 0.259478904420102 mirMAP -0.156825954386916 7.65587626809304e-09 NA NA NA hsa-miR-30d-3p PTEN -0.577371911152798 2.02950840095287e-06 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.199701101668772 1.32292586130764e-09 NA NA NA hsa-miR-30d-5p PTEN -0.38399848121878 0.000171129616944749 -0.105559265617794 0.259478904420102 mirMAP -0.220188562855424 2.47717470197967e-08 NA NA NA hsa-miR-30e-5p PTEN -1.02114836019762 6.81961221797866e-17 -0.105559265617794 0.259478904420102 mirMAP -0.117105233149191 0.000287532519172905 NA NA NA hsa-miR-320a PTEN 0.801356001806321 4.91397101474502e-09 -0.105559265617794 0.259478904420102 MirTarget;PITA;miRanda;miRNATAP -0.141503454711623 1.18141156695628e-06 NA NA NA hsa-miR-335-3p PTEN 0.336785882180547 0.0542446207938138 -0.105559265617794 0.259478904420102 MirTarget -0.112677059847725 1.04070864873638e-06 NA NA NA hsa-miR-374b-5p PTEN -0.288413933608091 0.0041474558664058 -0.105559265617794 0.259478904420102 MirTarget;mirMAP;miRNATAP -0.16851732961829 3.18032198525689e-05 NA NA NA hsa-miR-429 PTEN 0.559451508722375 0.00563641638673083 -0.105559265617794 0.259478904420102 PITA;miRanda;mirMAP;miRNATAP -0.150523780429582 1.52917738778381e-14 NA NA NA hsa-miR-454-3p PTEN 1.54137391927201 4.15861570449376e-20 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.109685346766956 2.22248900040344e-06 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-532-5p PTEN -0.021857649390892 0.830992272120134 -0.105559265617794 0.259478904420102 PITA;mirMAP;miRNATAP -0.202965037131022 3.33044253297789e-07 NA NA NA hsa-miR-582-3p PTEN -0.248056267546012 0.143798829508405 -0.105559265617794 0.259478904420102 PITA -0.104272846654196 1.24824461296463e-05 NA NA NA hsa-miR-590-5p PTEN 0.763025362395968 3.65305892505623e-09 -0.105559265617794 0.259478904420102 mirMAP -0.14144429591082 4.70302286754264e-06 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-7-1-3p PTEN 1.13646121619622 1.49823237535933e-14 -0.105559265617794 0.259478904420102 mirMAP -0.124388298964707 3.10112587036933e-06 NA NA NA hsa-miR-92a-3p PTEN 0.994679542307232 1.32587679156217e-16 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.200124132359 7.23918085276245e-10 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-93-5p PTEN 1.61042951896619 5.1280369606967e-24 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.189369301529539 1.58326496608035e-15 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-miR-455-5p RCHY1 1.408595672323 5.52039116456697e-22 -0.671047727328744 1.04158261403949e-16 miRanda -0.140197422780137 2.45176848050953e-09 NA NA NA hsa-miR-708-3p RCHY1 1.32647174389322 4.87465491977979e-16 -0.671047727328744 1.04158261403949e-16 MirTarget -0.108676577210354 3.60015530321524e-07 NA NA NA hsa-let-7e-5p RRM2 0.0857356192778891 0.512869729833211 1.43072923436349 4.76347605113061e-23 miRNATAP -0.116594885976381 0.0212921458521041 NA NA NA hsa-miR-100-5p RRM2 -1.85857794619369 1.248973638996e-25 1.43072923436349 4.76347605113061e-23 miRNAWalker2_validate -0.200687418277192 8.92534119980868e-09 NA NA NA hsa-miR-125a-5p RRM2 0.215366061934933 0.119550904549401 1.43072923436349 4.76347605113061e-23 miRanda -0.166440783233834 0.000485425098556746 NA NA NA hsa-miR-199a-5p RRM2 -0.364835768178638 0.0435119211101981 1.43072923436349 4.76347605113061e-23 miRanda -0.202244030529267 2.04040786612199e-08 NA NA NA hsa-miR-199b-5p RRM2 -1.08432682485992 7.68241801134089e-10 1.43072923436349 4.76347605113061e-23 miRanda -0.228289394052757 3.01620002310821e-10 NA NA NA hsa-miR-217 RRM2 -1.35391381055929 2.42394951427902e-09 1.43072923436349 4.76347605113061e-23 miRanda -0.131923693768233 3.35877251878021e-06 NA NA NA hsa-miR-26a-5p RRM2 -1.09269574587169 1.24020612216319e-22 1.43072923436349 4.76347605113061e-23 miRNAWalker2_validate -0.212127206493373 0.000184335826611229 NA NA NA hsa-miR-30a-5p RRM2 -1.79779915425811 1.93360169837799e-26 1.43072923436349 4.76347605113061e-23 miRNAWalker2_validate -0.289076549761803 1.18014872954407e-15 NA NA NA hsa-miR-7-1-3p RRM2B 1.13646121619622 1.49823237535933e-14 -0.128123172174143 0.179037133260049 mirMAP -0.142817263637725 1.36014390546721e-07 NA NA NA hsa-miR-103a-3p SERPINB5 0.556219385347418 1.55815736455067e-09 0.195467092677395 0.374442931189982 MirTarget -0.225932625344409 0.0293991612448752 NA NA NA hsa-miR-107 SERPINB5 -0.0447040564279497 0.671618791096755 0.195467092677395 0.374442931189982 MirTarget;miRanda -0.257230162905978 0.00505194431322522 NA NA NA hsa-miR-16-5p SERPINB5 0.521122945828175 1.40561786410572e-06 0.195467092677395 0.374442931189982 miRNAWalker2_validate -0.35749735523644 5.01089434926055e-05 NA NA NA hsa-miR-186-5p SERPINB5 0.353452958261612 0.000145058448579496 0.195467092677395 0.374442931189982 mirMAP -0.479478844714824 3.19948122498841e-06 NA NA NA hsa-miR-199a-5p SERPINB5 -0.364835768178638 0.0435119211101981 0.195467092677395 0.374442931189982 miRanda -0.126387843553672 0.0172607139083172 NA NA NA hsa-miR-26b-5p SERPINB5 -0.254478038884324 0.0285227763044636 0.195467092677395 0.374442931189982 miRNAWalker2_validate -0.234236931352466 0.0047194858052241 NA NA NA hsa-miR-30a-5p SERPINB5 -1.79779915425811 1.93360169837799e-26 0.195467092677395 0.374442931189982 miRNAWalker2_validate -0.394271321582041 7.33480296016729e-14 NA NA NA hsa-miR-335-5p SERPINB5 -1.17227779671552 1.49282618530733e-10 0.195467092677395 0.374442931189982 miRNAWalker2_validate -0.285605698710171 1.97779947308378e-08 NA NA NA hsa-miR-590-3p SERPINB5 0.221436901462551 0.0965904764063157 0.195467092677395 0.374442931189982 miRanda;mirMAP -0.190487192690113 0.00835092191360349 NA NA NA hsa-miR-148a-3p SERPINE1 -0.428944290834563 0.00954246923521465 2.9800460155055 1.19587534601183e-23 miRNATAP -0.588614974561901 2.12257805079507e-13 NA NA NA hsa-miR-148a-5p SERPINE1 -1.00478606532747 1.38045244999229e-07 2.9800460155055 1.19587534601183e-23 miRNATAP -0.483536967493396 2.33591419513461e-12 NA NA NA hsa-miR-2110 SERPINE1 -0.097378294887309 0.534549425629295 2.9800460155055 1.19587534601183e-23 miRNATAP -0.180621425114151 0.0435664839882757 NA NA NA hsa-miR-30a-5p SERPINE1 -1.79779915425811 1.93360169837799e-26 2.9800460155055 1.19587534601183e-23 miRNATAP -0.538352757158472 6.00868327349311e-13 NA NA NA hsa-miR-30b-5p SERPINE1 -0.400238605368173 0.00346540992719245 2.9800460155055 1.19587534601183e-23 MirTarget -0.571395507493692 5.43373687267357e-09 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 0.021222006155897 0.886366656528128 2.9800460155055 1.19587534601183e-23 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.436659380942926 1.62646729429929e-06 NA NA NA hsa-miR-30d-5p SERPINE1 -0.38399848121878 0.000171129616944749 2.9800460155055 1.19587534601183e-23 miRNATAP -0.990118259600798 2.80475112753928e-14 NA NA NA hsa-miR-34a-5p SERPINE1 -0.117372471043915 0.364001947180738 2.9800460155055 1.19587534601183e-23 miRNATAP -0.695579360286566 1.94417698929934e-11 NA NA NA hsa-miR-378a-5p SERPINE1 -1.31095692407946 2.375328908085e-15 2.9800460155055 1.19587534601183e-23 MirTarget -0.818100657001554 3.87528348811537e-27 NA NA NA hsa-miR-769-5p SERPINE1 0.0865819375213306 0.445395188017017 2.9800460155055 1.19587534601183e-23 MirTarget;miRNATAP -0.464940639629924 0.000108602547545672 NA NA NA hsa-miR-942-5p SERPINE1 0.678652135586536 2.58063518495056e-07 2.9800460155055 1.19587534601183e-23 MirTarget -0.302350801947272 0.00309769215152792 NA NA NA hsa-miR-99a-5p SERPINE1 -2.344442285007 7.11841214134739e-24 2.9800460155055 1.19587534601183e-23 miRNAWalker2_validate -0.641238698328427 6.18498189813307e-35 NA NA NA hsa-miR-15b-5p SESN1 0.85315666454713 3.79816274836297e-12 -0.956593870335502 3.11673242319883e-20 MirTarget;miRNATAP -0.145277808468022 0.000104902093229544 NA NA NA hsa-miR-183-5p SESN1 1.4313129319945 6.25230916431996e-14 -0.956593870335502 3.11673242319883e-20 MirTarget -0.121792740843436 3.0477038560725e-07 NA NA NA hsa-miR-200c-3p SESN1 0.630251054099546 0.000131975031451555 -0.956593870335502 3.11673242319883e-20 MirTarget;miRNATAP -0.103449684497436 0.00025349147273149 24791940 We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2 GAPB/Nrf2 and SESN1 in ways that inhibits DNA double-strand breaks repair increase levels of reactive oxygen species and upregulate p21 drug resistance lung cancer hsa-miR-21-5p SESN1 1.62465922021121 3.44191300985109e-58 -0.956593870335502 3.11673242319883e-20 miRNAWalker2_validate -0.332983784803834 1.93054884426259e-16 NA NA NA hsa-miR-24-3p SESN1 0.13115428390042 0.203891651275156 -0.956593870335502 3.11673242319883e-20 miRNAWalker2_validate;MirTarget;miRNATAP -0.214844989779189 2.4425437453515e-06 NA NA NA hsa-miR-320b SESN1 1.23473838180754 3.04337566045537e-14 -0.956593870335502 3.11673242319883e-20 miRanda -0.133461776305955 1.84294820455119e-06 NA NA NA hsa-miR-424-5p SESN1 1.48125289532143 9.10372985713165e-19 -0.956593870335502 3.11673242319883e-20 MirTarget;miRNATAP -0.115311441305507 1.87796264757534e-05 NA NA NA hsa-miR-944 SESN1 1.47323925060177 2.61626403984929e-13 -0.956593870335502 3.11673242319883e-20 PITA;mirMAP -0.124615238642699 3.04225821490615e-08 NA NA NA hsa-miR-106a-5p SESN2 0.67978010057847 0.00221925869726092 -0.220566938026376 0.0522487270080071 miRNATAP -0.101073544273185 4.50465712309792e-06 NA NA NA hsa-miR-106b-5p SESN2 0.50378717276868 1.45412404526866e-05 -0.220566938026376 0.0522487270080071 miRNATAP -0.29549870354441 1.30954269964478e-12 NA NA NA hsa-miR-148a-3p SESN2 -0.428944290834563 0.00954246923521465 -0.220566938026376 0.0522487270080071 miRNATAP -0.155006877991531 1.6318708162542e-07 NA NA NA hsa-miR-23b-3p SESN2 -0.497563803223134 3.31483353357535e-05 -0.220566938026376 0.0522487270080071 miRNATAP -0.211870260933953 2.12613637907102e-07 NA NA NA hsa-miR-27b-3p SESN2 -0.732682718863563 2.26896143573324e-09 -0.220566938026376 0.0522487270080071 miRNATAP -0.173500379693755 1.252911536474e-05 NA NA NA hsa-miR-30d-3p SESN2 -0.577371911152798 2.02950840095287e-06 -0.220566938026376 0.0522487270080071 mirMAP -0.114826166926729 0.00469561825525212 NA NA NA hsa-miR-30e-3p SESN2 -0.890635378639789 1.65740480611339e-16 -0.220566938026376 0.0522487270080071 mirMAP -0.150659343939762 0.000741028174927056 NA NA NA hsa-miR-320b SESN2 1.23473838180754 3.04337566045537e-14 -0.220566938026376 0.0522487270080071 mirMAP -0.119042129875956 5.70819924072436e-05 NA NA NA hsa-miR-335-5p SESN2 -1.17227779671552 1.49282618530733e-10 -0.220566938026376 0.0522487270080071 miRNAWalker2_validate -0.114270218372006 1.52673172344672e-05 NA NA NA hsa-miR-429 SESN2 0.559451508722375 0.00563641638673083 -0.220566938026376 0.0522487270080071 miRNATAP -0.109956099768193 5.8723937399782e-06 NA NA NA hsa-miR-628-5p SESN2 -0.554239048796013 4.92386883216087e-05 -0.220566938026376 0.0522487270080071 mirMAP -0.139564189665941 0.000105733479634132 NA NA NA hsa-miR-93-3p SESN2 1.69225547123293 1.50964095575087e-25 -0.220566938026376 0.0522487270080071 mirMAP -0.125953625179453 1.34909197973167e-05 NA NA NA hsa-miR-93-5p SESN2 1.61042951896619 5.1280369606967e-24 -0.220566938026376 0.0522487270080071 miRNATAP -0.119823311448515 5.03741391394117e-05 NA NA NA hsa-miR-106a-5p SESN3 0.67978010057847 0.00221925869726092 0.77667804118452 0.000567302979428033 MirTarget -0.320097164580924 1.34369244777146e-13 NA NA NA hsa-miR-106b-5p SESN3 0.50378717276868 1.45412404526866e-05 0.77667804118452 0.000567302979428033 MirTarget -0.292578008420018 0.000543258575517213 NA NA NA hsa-miR-126-5p SESN3 -0.953529188793816 7.91719143295591e-16 0.77667804118452 0.000567302979428033 mirMAP -0.223032148357518 0.00613785221880957 NA NA NA hsa-miR-130a-3p SESN3 0.67051191119964 4.89747518735144e-06 0.77667804118452 0.000567302979428033 mirMAP -0.178683691266865 0.00750919225331865 NA NA NA hsa-miR-139-5p SESN3 -1.46099200329485 7.85040381494472e-22 0.77667804118452 0.000567302979428033 MirTarget;mirMAP -0.143567754798225 0.0213320460909916 NA NA NA hsa-miR-142-3p SESN3 1.12754191614028 1.68798138028946e-08 0.77667804118452 0.000567302979428033 miRanda -0.295912465522955 6.92112124782922e-10 NA NA NA hsa-miR-142-5p SESN3 0.288897753038094 0.0900009317815725 0.77667804118452 0.000567302979428033 mirMAP -0.35706657984028 3.99593325427383e-10 NA NA NA hsa-miR-146b-5p SESN3 0.917975986853978 3.33749259316025e-09 0.77667804118452 0.000567302979428033 PITA;miRanda;miRNATAP -0.299364701574376 1.51835490927624e-06 NA NA NA hsa-miR-16-2-3p SESN3 1.1567130855258 1.01867256952189e-14 0.77667804118452 0.000567302979428033 mirMAP -0.433230730887109 7.0487690905244e-12 NA NA NA hsa-miR-17-5p SESN3 1.41924888736771 2.75805544953758e-18 0.77667804118452 0.000567302979428033 MirTarget;TargetScan -0.13737815529283 0.0192791898545265 NA NA NA hsa-miR-181c-5p SESN3 -0.168991199007857 0.196949106150297 0.77667804118452 0.000567302979428033 MirTarget -0.322634924095434 1.82665438783257e-05 NA NA NA hsa-miR-186-5p SESN3 0.353452958261612 0.000145058448579496 0.77667804118452 0.000567302979428033 MirTarget -0.581262610329974 3.63216853568465e-08 NA NA NA hsa-miR-195-3p SESN3 -0.624259620429699 0.000164279659144497 0.77667804118452 0.000567302979428033 mirMAP -0.246681866780602 3.22637901294985e-05 NA NA NA hsa-miR-19b-1-5p SESN3 0.757034032029085 2.99828133413343e-07 0.77667804118452 0.000567302979428033 MirTarget -0.234313317166027 0.000387745740145644 NA NA NA hsa-miR-20a-5p SESN3 1.1531986665452 1.02385132917958e-11 0.77667804118452 0.000567302979428033 MirTarget -0.212493869493711 0.000188189860105307 NA NA NA hsa-miR-20b-5p SESN3 0.345967670847176 0.232014828043601 0.77667804118452 0.000567302979428033 MirTarget -0.27067802570635 3.11263219059092e-16 NA NA NA hsa-miR-25-3p SESN3 0.76549796417801 3.32282098247097e-11 0.77667804118452 0.000567302979428033 MirTarget;miRNATAP -0.532099845933956 1.44191014337863e-10 NA NA NA hsa-miR-26b-3p SESN3 0.421575313079363 0.00223298166810883 0.77667804118452 0.000567302979428033 MirTarget -0.257496265731311 0.00030936369692666 NA NA NA hsa-miR-29a-5p SESN3 0.323252792625584 0.0370417231222825 0.77667804118452 0.000567302979428033 MirTarget;mirMAP -0.316267362413108 5.59435865841105e-07 NA NA NA hsa-miR-29b-1-5p SESN3 1.39669186711325 4.36960953138935e-11 0.77667804118452 0.000567302979428033 mirMAP -0.188419838361201 3.49749014701935e-05 NA NA NA hsa-miR-30a-3p SESN3 -2.26144364746452 8.12421214153823e-31 0.77667804118452 0.000567302979428033 mirMAP -0.23409244215729 6.29941395547433e-07 NA NA NA hsa-miR-30d-3p SESN3 -0.577371911152798 2.02950840095287e-06 0.77667804118452 0.000567302979428033 mirMAP -0.579578538130781 2.62348444905972e-13 NA NA NA hsa-miR-30e-3p SESN3 -0.890635378639789 1.65740480611339e-16 0.77667804118452 0.000567302979428033 mirMAP -0.386977054326643 1.2900032332041e-05 NA NA NA hsa-miR-32-5p SESN3 -0.317310201890053 0.0102525324475293 0.77667804118452 0.000567302979428033 MirTarget;miRNATAP -0.462108738643427 5.08871679315207e-09 NA NA NA hsa-miR-320a SESN3 0.801356001806321 4.91397101474502e-09 0.77667804118452 0.000567302979428033 miRanda;mirMAP -0.30270203078122 1.92557783066005e-05 NA NA NA hsa-miR-320b SESN3 1.23473838180754 3.04337566045537e-14 0.77667804118452 0.000567302979428033 miRanda;mirMAP -0.120805684301788 0.0417115267960734 NA NA NA hsa-miR-339-5p SESN3 1.07771430326938 2.45772601859307e-09 0.77667804118452 0.000567302979428033 miRanda -0.181607451437162 0.000717663090937492 NA NA NA hsa-miR-340-5p SESN3 -0.608415693437977 4.44345153563513e-05 0.77667804118452 0.000567302979428033 mirMAP -0.26272570775018 6.31010546789672e-05 NA NA NA hsa-miR-3607-3p SESN3 1.01377165357363 9.13355519701165e-05 0.77667804118452 0.000567302979428033 MirTarget -0.194877531531236 2.00485875596568e-07 NA NA NA hsa-miR-363-3p SESN3 -0.608157508016978 0.0186109501272176 0.77667804118452 0.000567302979428033 MirTarget -0.293753735738329 2.36357792799626e-15 NA NA NA hsa-miR-374a-5p SESN3 -0.621903385111545 6.61791773205282e-12 0.77667804118452 0.000567302979428033 mirMAP -0.312839365446017 0.00373699036285547 NA NA NA hsa-miR-374b-5p SESN3 -0.288413933608091 0.0041474558664058 0.77667804118452 0.000567302979428033 mirMAP -0.536448653056931 3.96759627785591e-08 NA NA NA hsa-miR-454-3p SESN3 1.54137391927201 4.15861570449376e-20 0.77667804118452 0.000567302979428033 mirMAP -0.249777150331407 9.16245052564391e-06 NA NA NA hsa-miR-500a-5p SESN3 0.675401699376111 8.24389004707854e-05 0.77667804118452 0.000567302979428033 mirMAP -0.127733927140131 0.0257801612840838 NA NA NA hsa-miR-576-5p SESN3 0.940432050128373 6.90227595663302e-12 0.77667804118452 0.000567302979428033 mirMAP -0.324967178768384 3.71968575653315e-06 NA NA NA hsa-miR-582-5p SESN3 -0.0366995972742474 0.821827119138923 0.77667804118452 0.000567302979428033 MirTarget -0.538166126782385 3.81416219830589e-20 NA NA NA hsa-miR-590-3p SESN3 0.221436901462551 0.0965904764063157 0.77667804118452 0.000567302979428033 miRNAWalker2_validate;MirTarget;miRanda -0.397102180333934 6.72428935101247e-08 NA NA NA hsa-miR-625-3p SESN3 0.0858338965684338 0.484971431380441 0.77667804118452 0.000567302979428033 mirMAP -0.522759029419478 4.60776857199523e-11 NA NA NA hsa-miR-625-5p SESN3 0.346770617079364 0.02860843739549 0.77667804118452 0.000567302979428033 MirTarget -0.450199562584019 2.17113407885858e-13 NA NA NA hsa-miR-664a-3p SESN3 -0.256108763664991 0.0513188660751664 0.77667804118452 0.000567302979428033 MirTarget -0.212209845684766 0.00484614319365144 NA NA NA hsa-miR-664a-5p SESN3 -0.871809752100072 1.86842520324979e-08 0.77667804118452 0.000567302979428033 mirMAP -0.145070740935933 0.0216245226362968 NA NA NA hsa-miR-7-1-3p SESN3 1.13646121619622 1.49823237535933e-14 0.77667804118452 0.000567302979428033 MirTarget;mirMAP -0.331152445512916 2.90932454089287e-07 NA NA NA hsa-miR-92a-3p SESN3 0.994679542307232 1.32587679156217e-16 0.77667804118452 0.000567302979428033 MirTarget;miRNATAP -0.224773222442063 0.00492774276391777 NA NA NA hsa-miR-93-5p SESN3 1.61042951896619 5.1280369606967e-24 0.77667804118452 0.000567302979428033 MirTarget -0.213676750825941 0.000295132591719595 NA NA NA hsa-miR-34a-5p SFN -0.117372471043915 0.364001947180738 0.658921611118602 0.00447943363250081 miRNAWalker2_validate -0.273754495018025 0.00049656562222554 NA NA NA hsa-miR-1296-5p SHISA5 0.222558939893167 0.187044627254045 0.0112757374324719 0.90864437627934 miRNAWalker2_validate -0.154711480920904 5.80689739275749e-10 NA NA NA hsa-miR-140-5p SIAH1 -0.412389003031485 0.000136051708543369 0.695028461694744 1.42160034478959e-12 PITA;miRanda;miRNATAP -0.207774194261363 2.19499291468573e-07 NA NA NA hsa-miR-15b-5p SIAH1 0.85315666454713 3.79816274836297e-12 0.695028461694744 1.42160034478959e-12 miRNATAP -0.181053319601286 1.69772082360023e-07 NA NA NA hsa-miR-16-5p SIAH1 0.521122945828175 1.40561786410572e-06 0.695028461694744 1.42160034478959e-12 miRNATAP -0.194739668892016 1.13357316469618e-06 NA NA NA hsa-miR-195-5p SIAH1 -1.8367376818177 6.9944883988895e-31 0.695028461694744 1.42160034478959e-12 miRNATAP -0.133263109982517 2.01074749815401e-07 NA NA NA hsa-miR-200b-3p SIAH1 0.0717138787925347 0.682858087587209 0.695028461694744 1.42160034478959e-12 TargetScan -0.106298159106421 1.80557172080532e-05 NA NA NA hsa-miR-30a-3p SIAH1 -2.26144364746452 8.12421214153823e-31 0.695028461694744 1.42160034478959e-12 miRNATAP -0.174890148532465 7.30317535906173e-18 NA NA NA hsa-miR-30d-3p SIAH1 -0.577371911152798 2.02950840095287e-06 0.695028461694744 1.42160034478959e-12 miRNATAP -0.255415921773443 3.29312061122369e-13 NA NA NA hsa-miR-362-3p SIAH1 -0.697212068252854 2.61718493418184e-06 0.695028461694744 1.42160034478959e-12 miRanda -0.101004263498116 0.000561631453408437 NA NA NA hsa-miR-497-5p SIAH1 -0.966244470847844 5.26505649147857e-12 0.695028461694744 1.42160034478959e-12 miRNATAP -0.134167830537808 1.03851368746302e-05 NA NA NA hsa-miR-532-5p SIAH1 -0.021857649390892 0.830992272120134 0.695028461694744 1.42160034478959e-12 PITA;miRNATAP -0.19848824207632 3.48661485054702e-06 NA NA NA hsa-miR-590-3p SIAH1 0.221436901462551 0.0965904764063157 0.695028461694744 1.42160034478959e-12 PITA;miRanda;mirMAP -0.107278932511189 0.00108576154877503 NA NA NA hsa-miR-15a-5p STEAP3 0.783550182002274 2.60699595655907e-11 -0.0574104108754971 0.672644565353482 MirTarget -0.137584961659365 0.00552596603487643 NA NA NA hsa-miR-16-2-3p STEAP3 1.1567130855258 1.01867256952189e-14 -0.0574104108754971 0.672644565353482 mirMAP -0.134495933124187 0.000473674720515565 NA NA NA hsa-miR-16-5p STEAP3 0.521122945828175 1.40561786410572e-06 -0.0574104108754971 0.672644565353482 miRNAWalker2_validate;MirTarget -0.109022566708662 0.0461933969286667 NA NA NA hsa-miR-484 STEAP3 0.918280909791707 1.39168306854263e-14 -0.0574104108754971 0.672644565353482 MirTarget -0.242863649278347 4.39441063285286e-07 NA NA NA hsa-miR-576-5p STEAP3 0.940432050128373 6.90227595663302e-12 -0.0574104108754971 0.672644565353482 mirMAP -0.144492804070899 0.000630487483773819 NA NA NA hsa-let-7a-3p THBS1 0.0966652362351867 0.423761916840503 -0.0602688709574686 0.817102472377875 mirMAP -0.257626055880682 0.00641628779702676 NA NA NA hsa-miR-155-5p THBS1 0.533437622040649 0.00248671179205372 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate;mirMAP -0.17476722608862 0.006488079922108 NA NA NA hsa-miR-16-1-3p THBS1 0.955017760172879 5.95379292601146e-11 -0.0602688709574686 0.817102472377875 MirTarget -0.500955283959431 2.92731476405759e-11 NA NA NA hsa-miR-17-5p THBS1 1.41924888736771 2.75805544953758e-18 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.381344928892176 1.05498288528831e-08 NA NA NA hsa-miR-181c-5p THBS1 -0.168991199007857 0.196949106150297 -0.0602688709574686 0.817102472377875 mirMAP -0.247983674823625 0.00437646006301906 NA NA NA hsa-miR-182-5p THBS1 1.15060905311096 6.25565852529946e-10 -0.0602688709574686 0.817102472377875 MirTarget -0.309873212711269 1.84640622484898e-07 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-18a-5p THBS1 1.65455873230328 3.76457892277775e-20 -0.0602688709574686 0.817102472377875 MirTarget -0.24726989244349 4.30044680655473e-05 NA NA NA hsa-miR-19a-3p THBS1 1.35800152353624 2.80940447111944e-12 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.414578771692538 1.14486667604464e-13 NA NA NA hsa-miR-19b-3p THBS1 0.538732279378089 0.000622008277870679 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.579635022619252 1.04471069287289e-16 NA NA NA hsa-miR-200a-5p THBS1 0.701063526850019 0.000188402923774663 -0.0602688709574686 0.817102472377875 MirTarget -0.493887203406803 2.53713541729748e-17 NA NA NA hsa-miR-200b-5p THBS1 0.02621402664548 0.883725338810228 -0.0602688709574686 0.817102472377875 MirTarget -0.429279995414032 5.28189107350755e-12 NA NA NA hsa-miR-20a-5p THBS1 1.1531986665452 1.02385132917958e-11 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.475131098210825 1.34284170648631e-13 NA NA NA hsa-miR-32-5p THBS1 -0.317310201890053 0.0102525324475293 -0.0602688709574686 0.817102472377875 mirMAP -0.348384610454154 0.00014766125359508 NA NA NA hsa-miR-335-3p THBS1 0.336785882180547 0.0542446207938138 -0.0602688709574686 0.817102472377875 mirMAP -0.141787373884456 0.0290737565142173 NA NA NA hsa-miR-338-3p THBS1 -0.948755228846395 8.99167125682392e-08 -0.0602688709574686 0.817102472377875 MirTarget;PITA;miRanda -0.131596551797142 0.0376296868418167 NA NA NA hsa-miR-33a-3p THBS1 0.20371038027126 0.212335697664505 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.397919916365233 1.19875077545057e-08 NA NA NA hsa-miR-500a-5p THBS1 0.675401699376111 8.24389004707854e-05 -0.0602688709574686 0.817102472377875 mirMAP -0.36725155536225 1.649731351533e-08 NA NA NA hsa-miR-576-5p THBS1 0.940432050128373 6.90227595663302e-12 -0.0602688709574686 0.817102472377875 mirMAP -0.255507850086054 0.00165862768717641 NA NA NA hsa-miR-589-3p THBS1 1.59559692667315 6.2886410639161e-15 -0.0602688709574686 0.817102472377875 mirMAP -0.170472312541131 0.0024064977779302 NA NA NA hsa-miR-590-3p THBS1 0.221436901462551 0.0965904764063157 -0.0602688709574686 0.817102472377875 miRanda -0.20324364241363 0.0175241371365528 NA NA NA hsa-miR-590-5p THBS1 0.763025362395968 3.65305892505623e-09 -0.0602688709574686 0.817102472377875 miRanda;mirMAP -0.520750608832199 1.15560113303924e-09 NA NA NA hsa-miR-629-3p THBS1 1.43262037314105 2.37092217984413e-19 -0.0602688709574686 0.817102472377875 MirTarget -0.264076289477301 0.00011856285955883 NA NA NA hsa-miR-664a-3p THBS1 -0.256108763664991 0.0513188660751664 -0.0602688709574686 0.817102472377875 mirMAP -0.396960198069835 4.00846362134978e-06 NA NA NA hsa-miR-7-1-3p THBS1 1.13646121619622 1.49823237535933e-14 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.403917251404343 5.0859524726101e-08 NA NA NA hsa-miR-92a-3p THBS1 0.994679542307232 1.32587679156217e-16 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.672834298334846 7.04881253821255e-14 NA NA NA hsa-miR-26a-5p TNFRSF10B -1.09269574587169 1.24020612216319e-22 0.899245000221647 4.39740185337371e-13 mirMAP -0.169634213008881 0.000371413847003937 NA NA NA hsa-miR-30a-5p TNFRSF10B -1.79779915425811 1.93360169837799e-26 0.899245000221647 4.39740185337371e-13 miRNAWalker2_validate -0.100563840293477 0.00121972811884754 NA NA NA hsa-miR-27a-3p TP53 0.348456440505425 0.00126682892514312 -0.41755807197951 0.03001853518726 miRNAWalker2_validate -0.202518579356515 0.009421402460679 NA NA NA hsa-miR-127-5p TP73 -0.605739525751187 0.000636065602565634 0.727032903213249 2.81060475543339e-05 mirMAP -0.19376328921949 5.23307827135341e-06 NA NA NA hsa-miR-22-3p TP73 0.00776313533473072 0.926356548861307 0.727032903213249 2.81060475543339e-05 mirMAP -0.373630323632164 4.70784221173934e-05 NA NA NA hsa-let-7a-3p ZMAT3 0.0966652362351867 0.423761916840503 -0.374947087737091 0.0222410250064323 mirMAP -0.392886013753955 1.91936781575535e-11 NA NA NA hsa-miR-130a-3p ZMAT3 0.67051191119964 4.89747518735144e-06 -0.374947087737091 0.0222410250064323 MirTarget -0.472317910612094 1.98168716188651e-24 NA NA NA hsa-miR-148b-5p ZMAT3 1.1533193737265 7.26420964688337e-13 -0.374947087737091 0.0222410250064323 MirTarget -0.281684202782672 8.45420750942698e-11 NA NA NA hsa-miR-15a-5p ZMAT3 0.783550182002274 2.60699595655907e-11 -0.374947087737091 0.0222410250064323 MirTarget -0.59378912998694 3.46683530057543e-25 NA NA NA hsa-miR-16-5p ZMAT3 0.521122945828175 1.40561786410572e-06 -0.374947087737091 0.0222410250064323 MirTarget -0.175368453213684 0.00797740124164757 NA NA NA hsa-miR-17-5p ZMAT3 1.41924888736771 2.75805544953758e-18 -0.374947087737091 0.0222410250064323 mirMAP -0.374300520081297 7.41042635671514e-20 NA NA NA hsa-miR-182-5p ZMAT3 1.15060905311096 6.25565852529946e-10 -0.374947087737091 0.0222410250064323 mirMAP -0.135102988161193 0.000342075251356414 NA NA NA hsa-miR-186-5p ZMAT3 0.353452958261612 0.000145058448579496 -0.374947087737091 0.0222410250064323 MirTarget -0.514043336889129 1.31944204596092e-11 NA NA NA hsa-miR-18a-3p ZMAT3 1.82583720936229 7.51297960972179e-19 -0.374947087737091 0.0222410250064323 MirTarget -0.256299526487374 2.47054416694155e-14 NA NA NA hsa-miR-193a-3p ZMAT3 0.22120710726779 0.111827069464729 -0.374947087737091 0.0222410250064323 MirTarget -0.269711701625175 1.30713955086502e-07 NA NA NA hsa-miR-193b-3p ZMAT3 1.72788400801602 3.0722151264559e-21 -0.374947087737091 0.0222410250064323 MirTarget -0.318775698438682 2.04743092962038e-18 NA NA NA hsa-miR-19a-3p ZMAT3 1.35800152353624 2.80940447111944e-12 -0.374947087737091 0.0222410250064323 MirTarget -0.423145025329659 1.88166427502687e-36 NA NA NA hsa-miR-19b-3p ZMAT3 0.538732279378089 0.000622008277870679 -0.374947087737091 0.0222410250064323 MirTarget -0.512599122231322 1.67986114598575e-33 NA NA NA hsa-miR-20a-5p ZMAT3 1.1531986665452 1.02385132917958e-11 -0.374947087737091 0.0222410250064323 mirMAP -0.400274836750671 4.87067298731656e-24 NA NA NA hsa-miR-21-3p ZMAT3 1.25126438776674 2.4124216716282e-17 -0.374947087737091 0.0222410250064323 MirTarget -0.231650973424066 6.72435220083951e-07 NA NA NA hsa-miR-22-5p ZMAT3 0.706731861922839 3.44318705980007e-07 -0.374947087737091 0.0222410250064323 mirMAP -0.3899926011761 5.6103572897633e-15 NA NA NA hsa-miR-223-5p ZMAT3 0.119850522837464 0.593378022605214 -0.374947087737091 0.0222410250064323 mirMAP -0.160513251645749 3.9203478278216e-07 NA NA NA hsa-miR-29b-1-5p ZMAT3 1.39669186711325 4.36960953138935e-11 -0.374947087737091 0.0222410250064323 mirMAP -0.327949960242267 3.62900491693712e-25 NA NA NA hsa-miR-301a-3p ZMAT3 2.14132004241926 4.46255413526808e-25 -0.374947087737091 0.0222410250064323 MirTarget -0.264595840571059 1.25296630880775e-16 NA NA NA hsa-miR-31-5p ZMAT3 2.79079137807505 1.72181058015659e-13 -0.374947087737091 0.0222410250064323 mirMAP -0.133129088227526 2.74957386348819e-13 NA NA NA hsa-miR-320a ZMAT3 0.801356001806321 4.91397101474502e-09 -0.374947087737091 0.0222410250064323 miRanda;mirMAP -0.236265216859832 4.10158915469969e-06 NA NA NA hsa-miR-362-3p ZMAT3 -0.697212068252854 2.61718493418184e-06 -0.374947087737091 0.0222410250064323 MirTarget -0.234762887640526 8.61909070888219e-07 NA NA NA hsa-miR-362-5p ZMAT3 0.41089772861323 0.0404254902071382 -0.374947087737091 0.0222410250064323 mirMAP -0.333778771260668 1.71551566490689e-22 NA NA NA hsa-miR-374a-3p ZMAT3 -0.299190081500425 0.00682975596757891 -0.374947087737091 0.0222410250064323 MirTarget;miRNATAP -0.208293945229712 0.00133485109881662 NA NA NA hsa-miR-374b-5p ZMAT3 -0.288413933608091 0.0041474558664058 -0.374947087737091 0.0222410250064323 mirMAP -0.340874946863872 1.61525045269199e-06 NA NA NA hsa-miR-424-5p ZMAT3 1.48125289532143 9.10372985713165e-19 -0.374947087737091 0.0222410250064323 MirTarget -0.184052233026871 7.26768662576933e-06 NA NA NA hsa-miR-425-5p ZMAT3 0.931027421598738 6.46235724408844e-08 -0.374947087737091 0.0222410250064323 MirTarget -0.249186257683255 7.3877748990523e-10 NA NA NA hsa-miR-429 ZMAT3 0.559451508722375 0.00563641638673083 -0.374947087737091 0.0222410250064323 MirTarget;miRNATAP -0.10614092433427 0.00262819667513823 NA NA NA hsa-miR-454-3p ZMAT3 1.54137391927201 4.15861570449376e-20 -0.374947087737091 0.0222410250064323 MirTarget -0.445666394771781 1.22908499064189e-30 NA NA NA hsa-miR-501-5p ZMAT3 1.02806906860218 1.63456814370548e-09 -0.374947087737091 0.0222410250064323 MirTarget;mirMAP -0.266906283037411 9.57691764015798e-11 NA NA NA hsa-miR-550a-3p ZMAT3 1.63595944765448 5.87048146042097e-24 -0.374947087737091 0.0222410250064323 mirMAP -0.238665291965322 1.81168602604393e-08 NA NA NA hsa-miR-576-5p ZMAT3 0.940432050128373 6.90227595663302e-12 -0.374947087737091 0.0222410250064323 MirTarget -0.458679908378539 1.62596587085234e-20 NA NA NA hsa-miR-582-5p ZMAT3 -0.0366995972742474 0.821827119138923 -0.374947087737091 0.0222410250064323 MirTarget;mirMAP;miRNATAP -0.229969547306564 1.32935999387067e-07 NA NA NA hsa-miR-590-3p ZMAT3 0.221436901462551 0.0965904764063157 -0.374947087737091 0.0222410250064323 mirMAP;miRNATAP -0.273229096482864 3.13672907970638e-07 NA NA NA hsa-miR-590-5p ZMAT3 0.763025362395968 3.65305892505623e-09 -0.374947087737091 0.0222410250064323 miRanda -0.394941539219391 1.56123237841555e-13 NA NA NA hsa-miR-660-5p ZMAT3 -0.202705992887645 0.101093376073573 -0.374947087737091 0.0222410250064323 mirMAP -0.4024909817582 1.65895428960951e-12 NA NA NA hsa-miR-664a-3p ZMAT3 -0.256108763664991 0.0513188660751664 -0.374947087737091 0.0222410250064323 mirMAP -0.219030356514205 5.68326066809301e-05 NA NA NA hsa-miR-671-5p ZMAT3 1.90920358947989 6.8158317757852e-31 -0.374947087737091 0.0222410250064323 MirTarget -0.329933718410932 8.16816807568662e-17 NA NA NA hsa-miR-7-1-3p ZMAT3 1.13646121619622 1.49823237535933e-14 -0.374947087737091 0.0222410250064323 mirMAP -0.264540833386731 1.46045617358077e-08 NA NA NA hsa-miR-708-3p ZMAT3 1.32647174389322 4.87465491977979e-16 -0.374947087737091 0.0222410250064323 mirMAP -0.16584147356254 9.11639851287614e-05 NA NA NA hsa-miR-93-5p ZMAT3 1.61042951896619 5.1280369606967e-24 -0.374947087737091 0.0222410250064323 mirMAP -0.27674727852888 5.47982280187608e-11 NA NA NA hsa-miR-942-5p ZMAT3 0.678652135586536 2.58063518495056e-07 -0.374947087737091 0.0222410250064323 MirTarget -0.169402260078578 0.00165700712268054 NA NA NA