miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-200c-3p ABL2 3.50132673580082 2.42716349086937e-15 -0.318835189302919 0.0455399452105181 MirTarget -0.151868587711699 2.33456607871419e-21 NA NA NA hsa-miR-200c-3p ACTC1 3.50132673580082 2.42716349086937e-15 -7.18598491180022 4.5953181070502e-12 MirTarget -1.33961147875603 5.78382641132517e-39 NA NA NA hsa-miR-200c-3p ADAMTS3 3.50132673580082 2.42716349086937e-15 -1.18158075880111 0.00447810281876853 miRNATAP -0.412864046827974 4.8774551323927e-23 NA NA NA hsa-miR-200c-3p ADCY2 3.50132673580082 2.42716349086937e-15 -3.86571368883929 3.85227988382588e-11 MirTarget;miRNATAP -0.439764377269818 9.87649048383691e-13 NA NA NA hsa-miR-200c-3p AFF3 3.50132673580082 2.42716349086937e-15 -5.00307584182747 3.17401839817713e-23 MirTarget;miRNATAP -0.594392924880098 8.99521592502589e-30 NA NA NA hsa-miR-200c-3p AMOTL2 3.50132673580082 2.42716349086937e-15 -1.01147657574476 0.000152881926388237 MirTarget;miRNATAP -0.221900222592948 5.9023125330058e-16 NA NA NA hsa-miR-200c-3p ANKH 3.50132673580082 2.42716349086937e-15 -0.383033248037803 0.21653677802021 miRNATAP -0.293704999353824 4.38875978160917e-21 NA NA NA hsa-miR-200c-3p AP1S2 3.50132673580082 2.42716349086937e-15 -1.3126608153732 9.8644272412276e-09 MirTarget;miRNATAP -0.377382973437296 3.78470396738381e-76 NA NA NA hsa-miR-200c-3p ARHGAP20 3.50132673580082 2.42716349086937e-15 -3.51958526332557 1.95510990509183e-16 MirTarget;miRNATAP -0.506742392754481 2.98862963888212e-31 NA NA NA hsa-miR-200c-3p ARHGAP28 3.50132673580082 2.42716349086937e-15 -1.53718262476907 0.000527104725118492 MirTarget -0.204349679908854 1.23254912467264e-05 NA NA NA hsa-miR-200c-3p ARHGAP6 3.50132673580082 2.42716349086937e-15 -3.24747805818142 5.3316262029649e-12 MirTarget -0.119631574014 0.0192045055385265 NA NA NA hsa-miR-200c-3p ARHGEF17 3.50132673580082 2.42716349086937e-15 -1.19273341470048 1.04178493154994e-08 miRNATAP -0.235823385660431 1.17810613529354e-29 NA NA NA hsa-miR-200c-3p ARL10 3.50132673580082 2.42716349086937e-15 -1.12227531152641 0.00197533796722557 mirMAP -0.287585642120829 1.2253094566474e-14 NA NA NA hsa-miR-200c-3p ASAP1 3.50132673580082 2.42716349086937e-15 0.0593314983478699 0.779444757742406 MirTarget;miRNATAP -0.163513046625557 4.35908270922895e-14 NA NA NA hsa-miR-200c-3p ATXN1 3.50132673580082 2.42716349086937e-15 -1.5104377454496 2.95939614593378e-08 MirTarget;miRNATAP -0.244443711486558 3.1156591845051e-18 NA NA NA hsa-miR-200c-3p BACH2 3.50132673580082 2.42716349086937e-15 -1.52271748612635 0.00133867288726185 mirMAP -0.543118577995022 3.61874329395113e-31 NA NA NA hsa-miR-200c-3p BASP1 3.50132673580082 2.42716349086937e-15 -0.115765471779633 0.797246530625034 miRNATAP -0.189407017412651 6.11095304259437e-05 NA NA NA hsa-miR-200c-3p BCL2 3.50132673580082 2.42716349086937e-15 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.190113918290914 1.87463163361428e-10 NA NA NA hsa-miR-200c-3p BEND4 3.50132673580082 2.42716349086937e-15 -1.96898871811517 7.28857253483474e-05 mirMAP -0.318293614323673 8.49110039241365e-10 NA NA NA hsa-miR-200c-3p BNC2 3.50132673580082 2.42716349086937e-15 -2.95176911794991 3.46014802400024e-09 MirTarget -0.700058514263773 1.38610836642505e-48 NA NA NA hsa-miR-200c-3p C11orf87 3.50132673580082 2.42716349086937e-15 -1.54750698600423 0.0118571289052622 miRNATAP -0.339559370670116 1.28086252300675e-07 NA NA NA hsa-miR-200c-3p C17orf51 3.50132673580082 2.42716349086937e-15 -0.678914258700408 0.0225411911064938 mirMAP -0.276482032662449 3.7103405322735e-20 NA NA NA hsa-miR-200c-3p CACNA1C 3.50132673580082 2.42716349086937e-15 -2.53203105122136 8.2041496030931e-11 MirTarget -0.436093474539072 1.71924843611962e-28 NA NA NA hsa-miR-200c-3p CALU 3.50132673580082 2.42716349086937e-15 -0.148100201074846 0.463184247628706 MirTarget -0.230686970082118 1.2951659506794e-31 NA NA NA hsa-miR-200c-3p CBL 3.50132673580082 2.42716349086937e-15 -0.309132961135003 0.0648412067348561 MirTarget;mirMAP -0.105782323761434 1.02635974205051e-09 NA NA NA hsa-miR-200c-3p CDK6 3.50132673580082 2.42716349086937e-15 -0.774202349805119 0.064787030605636 mirMAP -0.320385878451071 9.82419842455136e-14 NA NA NA hsa-miR-200c-3p CELF2 3.50132673580082 2.42716349086937e-15 -3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.507522314324143 2.26364434641141e-39 NA NA NA hsa-miR-200c-3p CFL2 3.50132673580082 2.42716349086937e-15 -2.61712932503392 6.6876672984936e-21 MirTarget;miRNATAP -0.47775192139898 1.87065344817105e-77 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c breast cancer hsa-miR-200c-3p CHRDL1 3.50132673580082 2.42716349086937e-15 -6.14628787036669 1.26356425887682e-13 MirTarget -0.98650234374657 4.70579040070454e-32 NA NA NA hsa-miR-200c-3p CHST11 3.50132673580082 2.42716349086937e-15 0.53998313547079 0.231103989518921 mirMAP -0.40264937459085 1.14560011127373e-18 NA NA NA hsa-miR-200c-3p CIITA 3.50132673580082 2.42716349086937e-15 -0.0228897168841891 0.959678389546489 mirMAP -0.202127971747454 2.01835562533023e-05 NA NA NA hsa-miR-200c-3p CLIC4 3.50132673580082 2.42716349086937e-15 -1.72389310060141 6.21382968572505e-08 MirTarget;miRNATAP -0.456334265563461 6.59418212524645e-52 NA NA NA hsa-miR-200c-3p CLIP2 3.50132673580082 2.42716349086937e-15 -0.796927760614636 0.00157984633892106 MirTarget;miRNATAP -0.175775545212805 1.72562779319927e-11 NA NA NA hsa-miR-200c-3p CNN3 3.50132673580082 2.42716349086937e-15 -0.662842637540786 0.00534632089235666 MirTarget;miRNATAP -0.201796950162607 9.38690932877399e-17 NA NA NA hsa-miR-200c-3p CNTFR 3.50132673580082 2.42716349086937e-15 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.437014825669292 4.0789929368456e-09 NA NA NA hsa-miR-200c-3p CNTN1 3.50132673580082 2.42716349086937e-15 -4.98280431564283 1.02293078354206e-09 MirTarget;miRNATAP -0.740154385698551 1.87627897077188e-18 NA NA NA hsa-miR-200c-3p CNTN4 3.50132673580082 2.42716349086937e-15 -3.05744404253524 2.33735855987774e-12 miRNATAP -0.190477586382324 5.13970306737113e-05 NA NA NA hsa-miR-200c-3p COL4A3 3.50132673580082 2.42716349086937e-15 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.321328173209356 1.3577907991277e-06 NA NA NA hsa-miR-200c-3p COPS8 3.50132673580082 2.42716349086937e-15 -0.274921408047149 0.0139072510052669 MirTarget -0.109525312584179 9.05459223082766e-23 NA NA NA hsa-miR-200c-3p CORO1C 3.50132673580082 2.42716349086937e-15 -1.12142787999647 2.05016310243217e-07 MirTarget;miRNATAP -0.288905329274373 4.99892523482563e-44 NA NA NA hsa-miR-200c-3p CREB5 3.50132673580082 2.42716349086937e-15 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.470215746107068 2.55597087862817e-34 NA NA NA hsa-miR-200c-3p CYP1B1 3.50132673580082 2.42716349086937e-15 -2.81828860701069 1.61767262798723e-06 miRNATAP -0.551390909310453 4.13814066664356e-20 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response drug resistance kidney renal cell cancer hsa-miR-200c-3p CYTH3 3.50132673580082 2.42716349086937e-15 -0.272207622459217 0.193434635786576 MirTarget -0.171003717286142 1.06988133428323e-15 NA NA NA hsa-miR-200c-3p DACT1 3.50132673580082 2.42716349086937e-15 -1.78085143314576 2.05886005067419e-05 miRNATAP -0.468544911780467 1.83843895910496e-29 NA NA NA hsa-miR-200c-3p DCBLD2 3.50132673580082 2.42716349086937e-15 -0.127512036942836 0.735967995495379 MirTarget -0.310752657713804 7.31627359199509e-16 NA NA NA hsa-miR-200c-3p DDIT4L 3.50132673580082 2.42716349086937e-15 -1.9019553090965 0.000465737260753943 MirTarget -0.467650323407764 4.09937437157122e-17 NA NA NA hsa-miR-200c-3p DENND5A 3.50132673580082 2.42716349086937e-15 -1.18678560113232 3.24357450546046e-11 MirTarget -0.249801332535579 7.95460413188994e-48 NA NA NA hsa-miR-200c-3p DENND5B 3.50132673580082 2.42716349086937e-15 -1.35091655519941 9.63273930805463e-05 MirTarget;miRNATAP -0.388782737688361 1.06463025647737e-29 NA NA NA hsa-miR-200c-3p DIAPH2 3.50132673580082 2.42716349086937e-15 -0.88549037173207 0.000371181170963573 mirMAP -0.107512804024802 4.18557089948089e-05 NA NA NA hsa-miR-200c-3p DIXDC1 3.50132673580082 2.42716349086937e-15 -3.01066558370526 1.36952954348107e-19 MirTarget -0.51565835630041 5.52676022504697e-59 NA NA NA hsa-miR-200c-3p DLC1 3.50132673580082 2.42716349086937e-15 -1.80446027708783 9.14505487509203e-10 miRNATAP -0.196371174380724 2.83097145908007e-10 NA NA NA hsa-miR-200c-3p DMD 3.50132673580082 2.42716349086937e-15 -3.69368719337714 3.87883942927561e-15 miRNATAP -0.530227342483484 2.76303130186155e-28 NA NA NA hsa-miR-200c-3p DNAJB5 3.50132673580082 2.42716349086937e-15 -2.65207059462743 2.68507855515511e-15 miRNATAP -0.523417573865588 8.66882403219181e-62 NA NA NA hsa-miR-200c-3p DOCK4 3.50132673580082 2.42716349086937e-15 -0.482456191440432 0.0791191956674349 MirTarget -0.216394616263008 1.42811223993013e-14 NA NA NA hsa-miR-200c-3p DRP2 3.50132673580082 2.42716349086937e-15 -1.34779224755633 0.000228883511200255 mirMAP -0.3120874276009 8.16166065202024e-17 NA NA NA hsa-miR-200c-3p DST 3.50132673580082 2.42716349086937e-15 -1.11542714896545 9.14769438027749e-05 mirMAP -0.104545025716321 0.000541561844338111 NA NA NA hsa-miR-200c-3p DTNA 3.50132673580082 2.42716349086937e-15 -4.06049121456747 1.59577306327407e-12 MirTarget -0.646651183559355 1.51981975883497e-28 NA NA NA hsa-miR-200c-3p DUSP1 3.50132673580082 2.42716349086937e-15 -3.47418646928724 1.98436002754553e-20 MirTarget;miRNATAP -0.31571143226552 4.3503827266648e-15 NA NA NA hsa-miR-200c-3p DYNC1I1 3.50132673580082 2.42716349086937e-15 -2.0457299899893 0.00010088277927843 MirTarget -0.198092464250846 0.000383313936695602 NA NA NA hsa-miR-200c-3p DZIP1 3.50132673580082 2.42716349086937e-15 -1.57008196403815 1.8435672027566e-05 MirTarget -0.337163109371172 1.97667084535266e-19 NA NA NA hsa-miR-200c-3p EDNRA 3.50132673580082 2.42716349086937e-15 -2.18719306101688 8.33789654397051e-10 miRNAWalker2_validate;miRNATAP -0.429900561340471 6.58562337198449e-34 NA NA NA hsa-miR-200c-3p ELL2 3.50132673580082 2.42716349086937e-15 -1.08408930026814 1.18240618311454e-05 MirTarget -0.125624172249391 1.49662582237983e-06 NA NA NA hsa-miR-200c-3p ENTPD1 3.50132673580082 2.42716349086937e-15 -1.12219223948292 8.05257550730918e-10 MirTarget;mirMAP -0.242553477574852 1.25234085734162e-42 NA NA NA hsa-miR-200c-3p ERC1 3.50132673580082 2.42716349086937e-15 -1.0981015647741 3.01720605629387e-09 mirMAP -0.169927644147619 4.90694981992114e-19 NA NA NA hsa-miR-200c-3p ETS1 3.50132673580082 2.42716349086937e-15 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.128822600745719 7.61112410894651e-08 NA NA NA hsa-miR-200c-3p ETV5 3.50132673580082 2.42716349086937e-15 0.236527120804439 0.423051410174547 MirTarget;miRNATAP -0.203619656408979 2.22974291370174e-11 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration cell migration breast cancer hsa-miR-200c-3p EXT1 3.50132673580082 2.42716349086937e-15 0.128948722299907 0.573712409186736 mirMAP -0.120220274695418 4.78122263653565e-07 NA NA NA hsa-miR-200c-3p F2RL2 3.50132673580082 2.42716349086937e-15 -0.074170778593706 0.882857232515843 MirTarget -0.402243298496942 5.13495429583168e-15 NA NA NA hsa-miR-200c-3p FAT3 3.50132673580082 2.42716349086937e-15 -2.79096679677476 3.40343867448209e-06 MirTarget;miRNATAP -0.234039279680735 0.000251033036038252 NA NA NA hsa-miR-200c-3p FBLN5 3.50132673580082 2.42716349086937e-15 -2.7572810002915 1.11240697718667e-13 miRNAWalker2_validate;miRTarBase -0.400109932439159 7.56529266726843e-26 NA NA NA hsa-miR-200c-3p FGD1 3.50132673580082 2.42716349086937e-15 -0.0471679512075118 0.859636723526689 miRNATAP -0.176696411492912 1.39557182757149e-10 NA NA NA hsa-miR-200c-3p FGF18 3.50132673580082 2.42716349086937e-15 -1.42483047022124 0.00103718898766565 miRNATAP -0.257330688592158 1.44969551897125e-08 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-200c-3p FHL1 3.50132673580082 2.42716349086937e-15 -4.79489740738213 4.58621609455402e-20 MirTarget -0.777950964097711 1.07858115739551e-52 NA NA NA hsa-miR-200c-3p FHOD1 3.50132673580082 2.42716349086937e-15 0.606822113176475 0.000711612899453606 miRNAWalker2_validate -0.107419840638149 9.12437900743461e-09 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-200c-3p FKBP14 3.50132673580082 2.42716349086937e-15 0.0327877092565507 0.867884467649625 mirMAP -0.116653645937896 1.1313070245364e-08 NA NA NA hsa-miR-200c-3p FLI1 3.50132673580082 2.42716349086937e-15 -1.10881984531465 6.56713737767845e-05 MirTarget;miRNATAP -0.315112566669429 2.08862569284463e-30 NA NA NA hsa-miR-200c-3p FLNA 3.50132673580082 2.42716349086937e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.573278326556171 6.53243471319789e-65 NA NA NA hsa-miR-200c-3p FN1 3.50132673580082 2.42716349086937e-15 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661896693895972 1.64136219365611e-35 NA NA NA hsa-miR-200c-3p FOXF1 3.50132673580082 2.42716349086937e-15 -3.59969497191247 8.05975763421163e-22 MirTarget -0.332527775439702 1.38577657244357e-16 NA NA NA hsa-miR-200c-3p FSTL1 3.50132673580082 2.42716349086937e-15 -1.20409366079041 3.08470468877507e-05 MirTarget -0.363468259803467 2.09035802399296e-38 NA NA NA hsa-miR-200c-3p FUNDC2 3.50132673580082 2.42716349086937e-15 -0.540715808942645 1.0105042632278e-05 mirMAP -0.121594306752915 5.89365481587959e-23 NA NA NA hsa-miR-200c-3p FYN 3.50132673580082 2.42716349086937e-15 -1.46508592139092 9.74677213788621e-08 miRNATAP -0.35092340815277 3.35510281801253e-39 NA NA NA hsa-miR-200c-3p FZD4 3.50132673580082 2.42716349086937e-15 -0.82842258037894 0.00067769989049317 mirMAP -0.112009526076228 1.27368925786649e-05 NA NA NA hsa-miR-200c-3p GATA4 3.50132673580082 2.42716349086937e-15 0.21063442916978 0.736053452717422 MirTarget;miRNATAP -0.254174058833087 0.000106333228523155 NA NA NA hsa-miR-200c-3p GEM 3.50132673580082 2.42716349086937e-15 -3.69134770515528 5.61525969896728e-16 MirTarget;miRNATAP -0.59591901710192 2.64134984555771e-39 NA NA NA hsa-miR-200c-3p GFI1 3.50132673580082 2.42716349086937e-15 0.348773110565043 0.374815763211957 miRNATAP -0.13817000467087 0.000831176064758985 NA NA NA hsa-miR-200c-3p GFRA1 3.50132673580082 2.42716349086937e-15 -4.99535302188274 6.14065741522982e-16 mirMAP -0.326378196591011 1.11002175660837e-06 NA NA NA hsa-miR-200c-3p GJA3 3.50132673580082 2.42716349086937e-15 0.723342716596257 0.205005185873009 mirMAP -0.159359701759363 0.00815220732632135 NA NA NA hsa-miR-200c-3p GJC1 3.50132673580082 2.42716349086937e-15 -0.972020676723743 0.00222017431601357 MirTarget;miRNATAP -0.312348068065492 1.57157651177237e-22 NA NA NA hsa-miR-200c-3p GLI3 3.50132673580082 2.42716349086937e-15 -0.852256004040062 0.0202428205589312 miRNATAP -0.215624593712126 1.72674225472266e-08 NA NA NA hsa-miR-200c-3p GLIS2 3.50132673580082 2.42716349086937e-15 -0.610818722003668 0.0527901481345749 miRNATAP -0.314830299269461 1.99437681270576e-23 NA NA NA hsa-miR-200c-3p GLRX 3.50132673580082 2.42716349086937e-15 -0.275147826859437 0.316770480646163 MirTarget -0.167349180181311 4.33729502224369e-09 NA NA NA hsa-miR-200c-3p GNG4 3.50132673580082 2.42716349086937e-15 0.216159437363437 0.744682539041036 mirMAP -0.415747931208297 1.50663821120222e-09 NA NA NA hsa-miR-200c-3p GPM6A 3.50132673580082 2.42716349086937e-15 -4.42956657098415 1.14589092196157e-14 miRNATAP -0.612078374655501 3.81550733224843e-25 NA NA NA hsa-miR-200c-3p GPR146 3.50132673580082 2.42716349086937e-15 -1.48603298566623 8.59493020531833e-12 miRNATAP -0.180580311996315 2.30119345589293e-15 NA NA NA hsa-miR-200c-3p GPRASP2 3.50132673580082 2.42716349086937e-15 -1.4590659609289 3.45285620607504e-12 MirTarget -0.184563271399617 3.21750849985113e-17 NA NA NA hsa-miR-200c-3p GREM1 3.50132673580082 2.42716349086937e-15 0.08752650759248 0.914525538097529 MirTarget -0.651094007307394 5.51115376486247e-15 NA NA NA hsa-miR-200c-3p HCFC2 3.50132673580082 2.42716349086937e-15 -0.813476452597869 3.14714018131552e-07 miRNATAP -0.124569233080298 4.14807035121159e-14 NA NA NA hsa-miR-200c-3p HDAC4 3.50132673580082 2.42716349086937e-15 -1.80036091395253 1.96398022917234e-18 miRNATAP -0.259928770853832 5.69329528676252e-36 NA NA NA hsa-miR-200c-3p HIPK3 3.50132673580082 2.42716349086937e-15 -1.74508965708072 2.92750932105647e-06 MirTarget -0.181375750035182 4.43648446216615e-06 NA NA NA hsa-miR-200c-3p HIVEP3 3.50132673580082 2.42716349086937e-15 0.0288071997334853 0.920325184162576 miRNATAP -0.205021380547737 4.48369730907305e-12 NA NA NA hsa-miR-200c-3p HLF 3.50132673580082 2.42716349086937e-15 -5.48181644757567 4.24267397704754e-28 MirTarget;miRNATAP -0.598575582470935 4.30883090987262e-30 NA NA NA hsa-miR-200c-3p HPS5 3.50132673580082 2.42716349086937e-15 -0.387841491492044 0.0146097312589973 MirTarget -0.118001047291785 4.68258293953271e-13 NA NA NA hsa-miR-200c-3p HS3ST3A1 3.50132673580082 2.42716349086937e-15 -0.129308279745747 0.831566302453219 MirTarget -0.629342883381929 2.19650792869416e-25 NA NA NA hsa-miR-200c-3p HUNK 3.50132673580082 2.42716349086937e-15 -2.26986927474702 1.0712218399358e-05 mirMAP -0.232558300822558 2.06932756428887e-05 NA NA NA hsa-miR-200c-3p IFIT5 3.50132673580082 2.42716349086937e-15 -0.142910091937379 0.549505921470859 miRNATAP -0.130149067809263 1.62593220739266e-07 NA NA NA hsa-miR-200c-3p IGSF10 3.50132673580082 2.42716349086937e-15 -5.30237641574688 9.03000767899905e-16 MirTarget -0.543470626925824 8.24252002226486e-15 NA NA NA hsa-miR-200c-3p IL6ST 3.50132673580082 2.42716349086937e-15 -2.09967019941458 1.93264814611531e-05 mirMAP -0.351735931542591 6.11651430778903e-12 NA NA NA hsa-miR-200c-3p ITGA1 3.50132673580082 2.42716349086937e-15 -1.43194652766846 3.62878143052896e-06 MirTarget -0.340248985237553 3.10844394076231e-28 NA NA NA hsa-miR-200c-3p ITPR1 3.50132673580082 2.42716349086937e-15 -2.58213364075087 3.81753054779227e-18 miRNATAP -0.31074820203156 1.2207549117247e-23 NA NA NA hsa-miR-200c-3p ITPR2 3.50132673580082 2.42716349086937e-15 -0.177554271932524 0.436106439712671 MirTarget -0.148029930319774 3.31118529911441e-10 NA NA NA hsa-miR-200c-3p JAZF1 3.50132673580082 2.42716349086937e-15 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.417363984218602 1.18716870274506e-56 NA NA NA hsa-miR-200c-3p JUN 3.50132673580082 2.42716349086937e-15 -2.04611084807692 9.1524625995215e-13 MirTarget -0.195019704023245 1.57363395803084e-10 NA NA NA hsa-miR-200c-3p KCNJ2 3.50132673580082 2.42716349086937e-15 -0.281197518883409 0.36164514317052 miRNATAP -0.124610651814908 0.000116946913854337 NA NA NA hsa-miR-200c-3p KCNK2 3.50132673580082 2.42716349086937e-15 -3.96205468288205 7.92099572968654e-12 miRNATAP -0.50213809450649 1.09916918435836e-16 NA NA NA hsa-miR-200c-3p KCNQ4 3.50132673580082 2.42716349086937e-15 -2.63982014948538 9.7947726847549e-09 miRNATAP -0.358302675169609 9.31183107328647e-14 NA NA NA hsa-miR-200c-3p KCTD15 3.50132673580082 2.42716349086937e-15 -1.06705874417742 0.00366825813765896 MirTarget;miRNATAP -0.220435916662502 8.7146531556752e-09 NA NA NA hsa-miR-200c-3p KDR 3.50132673580082 2.42716349086937e-15 -0.809645188569233 0.00140156336172476 miRNATAP -0.100553706909197 0.000169957263481419 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-200c-3p KIAA1462 3.50132673580082 2.42716349086937e-15 -1.7207439664468 1.06773819784283e-07 MirTarget -0.390952395751051 2.06195319565717e-34 NA NA NA hsa-miR-200c-3p KIF13A 3.50132673580082 2.42716349086937e-15 -1.2222279491778 3.03312683064576e-07 miRNATAP -0.122766402832361 1.18858226926387e-06 NA NA NA hsa-miR-200c-3p KLF10 3.50132673580082 2.42716349086937e-15 -1.1318994696032 3.44782858605802e-06 miRNATAP -0.184441147618597 3.18068583459059e-13 NA NA NA hsa-miR-200c-3p KLF11 3.50132673580082 2.42716349086937e-15 -0.893024981436906 6.97406562236998e-06 miRNAWalker2_validate -0.110383564384376 1.28195112464854e-07 NA NA NA hsa-miR-200c-3p KLF13 3.50132673580082 2.42716349086937e-15 -1.16141618366409 1.36372480238947e-05 miRNATAP -0.223148359199938 4.62619342254457e-16 NA NA NA hsa-miR-200c-3p KLF4 3.50132673580082 2.42716349086937e-15 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.109582875233884 0.00217318206296219 NA NA NA hsa-miR-200c-3p KLF9 3.50132673580082 2.42716349086937e-15 -2.78806270116525 1.14874620908535e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.399931620637291 7.36174043539773e-36 NA NA NA hsa-miR-200c-3p KLHDC1 3.50132673580082 2.42716349086937e-15 -1.73790146573647 5.50971604888164e-11 MirTarget -0.116365121245843 4.36458789969234e-05 NA NA NA hsa-miR-200c-3p LAMC1 3.50132673580082 2.42716349086937e-15 -0.820359806292778 9.59613230767155e-05 MirTarget;miRNATAP -0.189567753679175 8.99034744541273e-19 NA NA NA hsa-miR-200c-3p LATS2 3.50132673580082 2.42716349086937e-15 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.25601848144934 2.48894504027114e-29 NA NA NA hsa-miR-200c-3p LHFP 3.50132673580082 2.42716349086937e-15 -1.83125704677191 4.20141501543429e-10 MirTarget;miRNATAP -0.360296521299789 2.49193500017075e-35 NA NA NA hsa-miR-200c-3p LIX1L 3.50132673580082 2.42716349086937e-15 -1.29493279298234 2.01115053124561e-08 MirTarget -0.343384608216057 3.2644648024768e-57 NA NA NA hsa-miR-200c-3p LPAR1 3.50132673580082 2.42716349086937e-15 -1.92450185312715 3.73367853480122e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.184541391970303 1.02192042157423e-07 NA NA NA hsa-miR-200c-3p LPIN1 3.50132673580082 2.42716349086937e-15 -0.89601675169461 0.000133989377531311 MirTarget -0.167389112818983 6.05721390462058e-12 NA NA NA hsa-miR-200c-3p MAF 3.50132673580082 2.42716349086937e-15 -1.28341922239874 0.00015825213662883 miRNATAP -0.35679417285462 9.60044419984967e-26 NA NA NA hsa-miR-200c-3p MAP2 3.50132673580082 2.42716349086937e-15 -0.753572928246066 0.0970780637395552 MirTarget;miRNATAP -0.257792003422747 5.10723168629245e-08 NA NA NA hsa-miR-200c-3p MARCH1 3.50132673580082 2.42716349086937e-15 0.249895584717324 0.347593448523703 MirTarget -0.18533085182802 1.3644751877114e-11 NA NA NA hsa-miR-200c-3p MARCH8 3.50132673580082 2.42716349086937e-15 -0.883350326074423 0.00115126355540274 MirTarget -0.122969126976633 1.72281063834122e-05 NA NA NA hsa-miR-200c-3p MBNL1 3.50132673580082 2.42716349086937e-15 -1.03715217368983 1.91023114600054e-14 miRNATAP -0.146834845139787 2.78385451063201e-26 NA NA NA hsa-miR-200c-3p MCFD2 3.50132673580082 2.42716349086937e-15 -0.273710952309139 0.0802130111446696 MirTarget -0.12819612269317 8.21003055750594e-16 NA NA NA hsa-miR-200c-3p MEF2D 3.50132673580082 2.42716349086937e-15 -1.254473345286 3.30937184393369e-26 mirMAP -0.141713246594008 1.44643390522484e-30 NA NA NA hsa-miR-200c-3p MEGF10 3.50132673580082 2.42716349086937e-15 -0.573869708612628 0.230704357125925 MirTarget -0.148472724346704 0.0032645910758475 NA NA NA hsa-miR-200c-3p MEX3B 3.50132673580082 2.42716349086937e-15 0.132596726412779 0.712673599662109 miRNATAP -0.211675745417146 1.51022537157754e-08 NA NA NA hsa-miR-200c-3p MFAP5 3.50132673580082 2.42716349086937e-15 -4.35255383201982 2.63926165947326e-07 miRNATAP -0.904430228024108 2.48772724952338e-26 NA NA NA hsa-miR-200c-3p MITF 3.50132673580082 2.42716349086937e-15 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.370919113758088 3.74236352265043e-25 NA NA NA hsa-miR-200c-3p MMD 3.50132673580082 2.42716349086937e-15 -0.0500962943374854 0.870546787744501 miRNATAP -0.308170884248988 9.44343148595576e-24 NA NA NA hsa-miR-200c-3p MMGT1 3.50132673580082 2.42716349086937e-15 -0.68742046704414 1.47427584314027e-05 MirTarget -0.136129522367508 5.42287995510645e-17 NA NA NA hsa-miR-200c-3p MPDZ 3.50132673580082 2.42716349086937e-15 -1.47308852519181 6.37797234153348e-08 MirTarget -0.205162160438677 5.35039020193225e-13 NA NA NA hsa-miR-200c-3p MRVI1 3.50132673580082 2.42716349086937e-15 -3.20095302741943 3.61514805440821e-17 MirTarget -0.427481623224712 8.25619928188081e-28 NA NA NA hsa-miR-200c-3p MSN 3.50132673580082 2.42716349086937e-15 -0.85546319996218 0.0136615174636227 miRNAWalker2_validate;miRTarBase;MirTarget -0.394048408331182 7.19357787283363e-31 NA NA NA hsa-miR-200c-3p MSRB3 3.50132673580082 2.42716349086937e-15 -3.32124931554379 1.17358848755899e-14 mirMAP -0.636225939222873 9.31523742862297e-54 NA NA NA hsa-miR-200c-3p MTAP 3.50132673580082 2.42716349086937e-15 -0.408994822912712 0.41815782159096 MirTarget -0.216008458217344 4.55752299665167e-05 NA NA NA hsa-miR-200c-3p MYO5A 3.50132673580082 2.42716349086937e-15 -0.274576441491861 0.311620335084615 mirMAP -0.235049265780314 1.34071002498579e-17 NA NA NA hsa-miR-200c-3p NALCN 3.50132673580082 2.42716349086937e-15 -1.70339745207592 0.000986552762067509 MirTarget -0.198470253596997 0.000282759198742808 NA NA NA hsa-miR-200c-3p NCAM1 3.50132673580082 2.42716349086937e-15 -5.46812766536887 2.35522582039703e-18 miRTarBase -0.866990545789506 1.62442785889179e-44 NA NA NA hsa-miR-200c-3p NCS1 3.50132673580082 2.42716349086937e-15 -1.7356703955299 3.35229307090603e-12 miRNATAP -0.304535657151827 1.94257399715938e-34 NA NA NA hsa-miR-200c-3p NDN 3.50132673580082 2.42716349086937e-15 -1.97097807251037 3.42025004662974e-07 MirTarget;miRNATAP -0.21963095607133 7.55469106933536e-08 NA NA NA hsa-miR-200c-3p NDST1 3.50132673580082 2.42716349086937e-15 -0.250883286824299 0.176743296307116 miRNATAP -0.121801461619426 2.14091669862434e-10 NA NA NA hsa-miR-200c-3p NEGR1 3.50132673580082 2.42716349086937e-15 -4.77810063590076 6.81978052859699e-19 miRNATAP -0.681089626504163 8.64401576200308e-36 NA NA NA hsa-miR-200c-3p NEK9 3.50132673580082 2.42716349086937e-15 -0.68505771922002 5.87748183701095e-07 MirTarget -0.101670615640732 9.27048246413276e-13 NA NA NA hsa-miR-200c-3p NFASC 3.50132673580082 2.42716349086937e-15 -2.95717922837883 4.31475260476481e-14 miRNATAP -0.304840184738999 2.10611001389752e-13 23185507 miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer breast cancer hsa-miR-200c-3p NFIA 3.50132673580082 2.42716349086937e-15 -2.09936885926166 1.0458025267903e-15 MirTarget;miRNATAP -0.200285957581366 6.83765670745436e-13 NA NA NA hsa-miR-200c-3p NFIB 3.50132673580082 2.42716349086937e-15 -1.72909658442002 3.18902339154006e-09 miRNATAP -0.213084274434391 3.61043657901559e-12 NA NA NA hsa-miR-200c-3p NOG 3.50132673580082 2.42716349086937e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.376049889176797 2.18212060301929e-09 NA NA NA hsa-miR-200c-3p NOVA1 3.50132673580082 2.42716349086937e-15 -4.21914714578111 7.21315612695789e-16 MirTarget;miRNATAP -0.420421113341647 4.0648338601721e-14 NA NA NA hsa-miR-200c-3p NPC1 3.50132673580082 2.42716349086937e-15 -0.0845907427747106 0.656311240831085 MirTarget -0.123577565385806 3.00645786245411e-10 NA NA NA hsa-miR-200c-3p NR3C1 3.50132673580082 2.42716349086937e-15 -1.29490546417786 3.89055618845506e-05 miRNATAP -0.314248714852543 4.66913145651316e-23 NA NA NA hsa-miR-200c-3p NR5A2 3.50132673580082 2.42716349086937e-15 -1.30745675590419 3.0949312510936e-06 miRNATAP -0.120332151497725 5.22354106198246e-05 NA NA NA hsa-miR-200c-3p NRG1 3.50132673580082 2.42716349086937e-15 -1.2378190219847 0.0741741552249905 miRNATAP -0.385142513117602 1.00816945988738e-07 NA NA NA hsa-miR-200c-3p NRIP3 3.50132673580082 2.42716349086937e-15 0.266916024330568 0.374772934924586 mirMAP -0.114212099439722 0.00029942373521186 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-200c-3p OSTM1 3.50132673580082 2.42716349086937e-15 -0.771975269003669 5.13573784724769e-06 MirTarget -0.194766497800319 2.66480355003549e-31 NA NA NA hsa-miR-200c-3p PALM2-AKAP2 3.50132673580082 2.42716349086937e-15 -1.62425751829219 3.00539592164251e-07 miRNATAP -0.423109617127978 1.14386142925674e-43 NA NA NA hsa-miR-200c-3p PAM 3.50132673580082 2.42716349086937e-15 -1.35766444679164 1.04680437362722e-07 miRNATAP -0.266951913565069 4.25654425779481e-25 NA NA NA hsa-miR-200c-3p PARD3B 3.50132673580082 2.42716349086937e-15 -2.99814829542465 1.05899403250138e-11 MirTarget;miRNATAP -0.267343590479044 1.34152057681657e-08 NA NA NA hsa-miR-200c-3p PCDH10 3.50132673580082 2.42716349086937e-15 -3.23750023602778 3.50143209305191e-07 MirTarget -0.525549846290652 1.40969347650151e-15 NA NA NA hsa-miR-200c-3p PCDH19 3.50132673580082 2.42716349086937e-15 -2.41945740586477 5.73468735015548e-07 miRNATAP -0.156524617218137 0.00246792299295543 NA NA NA hsa-miR-200c-3p PCSK2 3.50132673580082 2.42716349086937e-15 -6.63257584033356 1.5810712933526e-27 miRNATAP -0.387549940282484 1.11101205605129e-08 NA NA NA hsa-miR-200c-3p PDE4D 3.50132673580082 2.42716349086937e-15 -2.16999194209536 1.89831164898157e-16 mirMAP -0.184616201011291 6.88048055797604e-11 NA NA NA hsa-miR-200c-3p PDE5A 3.50132673580082 2.42716349086937e-15 -2.72242827068326 2.90742264752214e-19 miRNATAP -0.300696725838192 4.90943616505544e-21 NA NA NA hsa-miR-200c-3p PEG10 3.50132673580082 2.42716349086937e-15 -1.94098497488928 0.00571305721030311 mirMAP -0.229152283070274 0.00203538645560581 NA NA NA hsa-miR-200c-3p PHLDB1 3.50132673580082 2.42716349086937e-15 -0.688909556015726 0.00122355801941463 MirTarget;miRNATAP -0.192312421062445 6.25242384626231e-19 NA NA NA hsa-miR-200c-3p PLCL1 3.50132673580082 2.42716349086937e-15 -2.35657424868599 1.25135556692163e-13 MirTarget -0.408828817205366 2.17160107267565e-38 NA NA NA hsa-miR-200c-3p PLK2 3.50132673580082 2.42716349086937e-15 -0.184734083567005 0.553818611811747 miRNATAP -0.153685938478197 2.41030637915006e-06 NA NA NA hsa-miR-200c-3p PLXNA4 3.50132673580082 2.42716349086937e-15 -2.25456361904941 4.96438419774251e-05 miRNATAP -0.679926341659152 5.4086890819909e-36 NA NA NA hsa-miR-200c-3p PLXNC1 3.50132673580082 2.42716349086937e-15 -0.532339572840622 0.284697523094741 miRNATAP -0.428294069530617 2.38986484144414e-17 NA NA NA hsa-miR-200c-3p PPARGC1A 3.50132673580082 2.42716349086937e-15 -4.12246484079635 1.21340396096287e-10 mirMAP -0.483417114278318 7.39173001877038e-13 NA NA NA hsa-miR-200c-3p PPM1F 3.50132673580082 2.42716349086937e-15 -0.484267586694392 0.00139346420727647 miRNAWalker2_validate;MirTarget;miRNATAP -0.133273390159974 4.78555485126521e-18 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-200c-3p PPP2R2C 3.50132673580082 2.42716349086937e-15 -0.795459846555288 0.266159255773917 miRNATAP -0.306291787073106 4.49365552911052e-05 NA NA NA hsa-miR-200c-3p PRDM1 3.50132673580082 2.42716349086937e-15 -0.799773282697487 0.0106840144209139 miRNATAP -0.101768221707449 0.00210189024339143 NA NA NA hsa-miR-200c-3p PRDM16 3.50132673580082 2.42716349086937e-15 -2.56004666228196 1.1360029849919e-06 MirTarget;miRNATAP -0.298506679024547 7.59595353156344e-08 NA NA NA hsa-miR-200c-3p PRKAA2 3.50132673580082 2.42716349086937e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.3165574137351 2.9537182424848e-08 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-200c-3p PRKAR2B 3.50132673580082 2.42716349086937e-15 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.267488379876048 7.71967366135021e-12 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-200c-3p PRKG1 3.50132673580082 2.42716349086937e-15 -3.08984703833363 4.55204333556294e-10 miRNATAP -0.562636021923416 1.62782418772395e-29 NA NA NA hsa-miR-200c-3p PRLR 3.50132673580082 2.42716349086937e-15 -0.790590749858476 0.188888563043757 mirMAP -0.150743243476538 0.0177144148281411 NA NA NA hsa-miR-200c-3p PSIP1 3.50132673580082 2.42716349086937e-15 -0.69271775262539 0.00369263349962018 MirTarget;miRNATAP -0.170802465591392 4.23477325340041e-12 NA NA NA hsa-miR-200c-3p PTHLH 3.50132673580082 2.42716349086937e-15 -0.637337427958821 0.359541326845111 MirTarget -0.321174456367142 1.03989013458563e-05 NA NA NA hsa-miR-200c-3p PTPN21 3.50132673580082 2.42716349086937e-15 -1.00705050330315 2.27967729064557e-07 miRNATAP -0.118883981502558 6.41241001696586e-09 NA NA NA hsa-miR-200c-3p PTPRD 3.50132673580082 2.42716349086937e-15 -3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate -0.631789922953883 8.61910701410587e-25 NA NA NA hsa-miR-200c-3p PTPRZ1 3.50132673580082 2.42716349086937e-15 -3.06984706543687 0.00081651312572712 MirTarget;miRNATAP -0.421932299469652 1.27346651460668e-05 NA NA NA hsa-miR-200c-3p PYGO1 3.50132673580082 2.42716349086937e-15 -2.10178219794221 4.03238443886891e-05 mirMAP -0.410995557662133 7.28369892582507e-15 NA NA NA hsa-miR-200c-3p RASSF2 3.50132673580082 2.42716349086937e-15 -1.41203583911444 3.41019630784437e-05 miRNAWalker2_validate -0.163814129885691 5.29293063059862e-06 NA NA NA hsa-miR-200c-3p RASSF8 3.50132673580082 2.42716349086937e-15 -1.48887021923134 4.62579164697906e-06 miRNATAP -0.314866562878241 1.49954673919764e-21 NA NA NA hsa-miR-200c-3p RBM20 3.50132673580082 2.42716349086937e-15 -2.46227191748389 1.31938346873951e-07 MirTarget -0.267854349947843 5.72459825885424e-08 NA NA NA hsa-miR-200c-3p RECK 3.50132673580082 2.42716349086937e-15 -2.38610578026315 7.82688892259109e-14 miRNATAP -0.450430701110267 5.413160156224e-48 27574450;24647918 MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression cell migration; bladder cancer;lung cancer hsa-miR-200c-3p REEP1 3.50132673580082 2.42716349086937e-15 -4.34753961523252 3.78306600846853e-15 MirTarget;miRNATAP -0.60798144951987 9.68205191169038e-27 NA NA NA hsa-miR-200c-3p RELN 3.50132673580082 2.42716349086937e-15 -4.70097153618157 2.41994737445055e-14 MirTarget -0.654129820157615 6.78543521649521e-25 NA NA NA hsa-miR-200c-3p RFTN2 3.50132673580082 2.42716349086937e-15 -1.41911132096922 1.31506326408267e-08 MirTarget -0.168323840026862 1.47293350292805e-10 NA NA NA hsa-miR-200c-3p RGL1 3.50132673580082 2.42716349086937e-15 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.267570265729395 7.95898817127779e-24 NA NA NA hsa-miR-200c-3p RIMKLB 3.50132673580082 2.42716349086937e-15 -0.825833788774339 0.00780804620647977 MirTarget;miRNATAP -0.172631359326516 1.02643399584783e-07 NA NA NA hsa-miR-200c-3p RIMS2 3.50132673580082 2.42716349086937e-15 -2.03271632474241 0.00172161214577439 MirTarget -0.16389295395964 0.0172649663912246 NA NA NA hsa-miR-200c-3p RIN2 3.50132673580082 2.42716349086937e-15 0.108109453171399 0.623647304950009 miRNAWalker2_validate -0.104557875226358 5.52655449672694e-06 NA NA NA hsa-miR-200c-3p RND3 3.50132673580082 2.42716349086937e-15 -1.48017982993852 1.2895596822753e-07 MirTarget;miRNATAP -0.16584902775001 2.0865793459284e-08 23821457 MicroRNA 200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE gastric cancer hsa-miR-200c-3p RPS6KA2 3.50132673580082 2.42716349086937e-15 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.129334089352011 4.4517289901593e-06 NA NA NA hsa-miR-200c-3p RUSC2 3.50132673580082 2.42716349086937e-15 -1.59852075923141 8.04308093421491e-11 miRNATAP -0.332927858785705 2.94321058698259e-44 NA NA NA hsa-miR-200c-3p SCHIP1 3.50132673580082 2.42716349086937e-15 -1.15670143162604 1.15787017339655e-06 miRNATAP -0.248243798490195 3.81900317798344e-25 NA NA NA hsa-miR-200c-3p SCN2A 3.50132673580082 2.42716349086937e-15 -1.29167455183038 0.0301757402573598 MirTarget;miRNATAP -0.260085919342346 3.27763228347355e-05 NA NA NA hsa-miR-200c-3p SCN3A 3.50132673580082 2.42716349086937e-15 -2.32699009748223 7.40591172107087e-07 mirMAP -0.315258532252987 1.58612630302652e-10 NA NA NA hsa-miR-200c-3p SCUBE3 3.50132673580082 2.42716349086937e-15 -2.48127471582544 2.66234551923326e-07 mirMAP -0.385334863448361 1.41921436053361e-14 NA NA NA hsa-miR-200c-3p SDC2 3.50132673580082 2.42716349086937e-15 -2.00706478458987 1.28300608152733e-09 miRNATAP -0.331251769489888 1.17181582498384e-22 NA NA NA hsa-miR-200c-3p SEC23A 3.50132673580082 2.42716349086937e-15 -0.851484611346241 3.97374078989646e-06 MirTarget;miRNATAP -0.213188508576225 1.57444863860176e-31 21593139 A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c prostate cancer hsa-miR-200c-3p SEMA6D 3.50132673580082 2.42716349086937e-15 -1.94164031321549 1.1489424743785e-07 miRNATAP -0.25083186056663 6.73131670333037e-11 NA NA NA hsa-miR-200c-3p SERINC1 3.50132673580082 2.42716349086937e-15 -1.06295473287643 5.49350211423462e-13 MirTarget;miRNATAP -0.121663127328767 3.49946305209744e-15 NA NA NA hsa-miR-200c-3p SETD7 3.50132673580082 2.42716349086937e-15 -1.13463057726458 1.78342966519954e-10 miRNATAP -0.160518940134969 2.72739618225597e-18 NA NA NA hsa-miR-200c-3p SFMBT2 3.50132673580082 2.42716349086937e-15 -1.41454985454287 0.000416308526551551 mirMAP -0.349056411453125 1.56123571326781e-17 NA NA NA hsa-miR-200c-3p SGCD 3.50132673580082 2.42716349086937e-15 -3.54960120603853 1.88168939363754e-09 mirMAP -0.674570017915175 5.40649659440121e-30 NA NA NA hsa-miR-200c-3p SGIP1 3.50132673580082 2.42716349086937e-15 -0.435449323177095 0.231015167394361 MirTarget -0.324279345851272 1.23552072204793e-18 NA NA NA hsa-miR-200c-3p SGPP1 3.50132673580082 2.42716349086937e-15 -0.148910476883497 0.606055761679441 MirTarget -0.17336001507914 7.1513549714889e-09 NA NA NA hsa-miR-200c-3p SH3PXD2A 3.50132673580082 2.42716349086937e-15 -0.987155493438988 1.02406192375196e-05 miRNATAP -0.103026328658852 1.33396126608335e-05 NA NA NA hsa-miR-200c-3p SHE 3.50132673580082 2.42716349086937e-15 -2.12174612226388 6.45456472105851e-13 mirMAP -0.346237361482731 2.73958243144482e-31 NA NA NA hsa-miR-200c-3p SIRPA 3.50132673580082 2.42716349086937e-15 -0.55339733363088 0.119266182012343 MirTarget -0.382259349502016 1.54540408894156e-27 NA NA NA hsa-miR-200c-3p SLC16A12 3.50132673580082 2.42716349086937e-15 -0.975164130666574 0.0455225768500397 mirMAP;miRNATAP -0.312853270378774 6.26610008780758e-10 NA NA NA hsa-miR-200c-3p SLC16A2 3.50132673580082 2.42716349086937e-15 -1.53927355158781 4.3817377775803e-06 miRNATAP -0.39526770609163 6.41326684117318e-33 NA NA NA hsa-miR-200c-3p SLC1A2 3.50132673580082 2.42716349086937e-15 -1.63926856184029 0.00011983867188635 MirTarget;miRNATAP -0.273838691448261 7.59924661422873e-10 NA NA NA hsa-miR-200c-3p SLC30A4 3.50132673580082 2.42716349086937e-15 -1.12863913918651 0.00370195756593126 mirMAP -0.373474811983133 1.75276250787592e-21 NA NA NA hsa-miR-200c-3p SLC35B4 3.50132673580082 2.42716349086937e-15 -0.0558520609113842 0.697638933075465 MirTarget -0.116261042575822 1.73957643663548e-15 NA NA NA hsa-miR-200c-3p SLC39A8 3.50132673580082 2.42716349086937e-15 0.248276675119964 0.380319177862353 MirTarget -0.186297567113022 1.88652901799459e-10 NA NA NA hsa-miR-200c-3p SLC6A17 3.50132673580082 2.42716349086937e-15 0.941104200796897 0.0568131902197341 mirMAP;miRNATAP -0.338531774539117 3.42406203332552e-11 NA NA NA hsa-miR-200c-3p SNAI2 3.50132673580082 2.42716349086937e-15 -0.280307189347724 0.489884936104145 miRNATAP -0.183480437180395 1.58844201912264e-05 NA NA NA hsa-miR-200c-3p SNAP25 3.50132673580082 2.42716349086937e-15 -1.14591384974572 0.0327342558924054 MirTarget;miRNATAP -0.463254365225422 2.23415552337194e-17 NA NA NA hsa-miR-200c-3p SOX6 3.50132673580082 2.42716349086937e-15 -2.16170894059309 7.49520430040923e-06 mirMAP;miRNATAP -0.138254970031974 0.00723892899868318 NA NA NA hsa-miR-200c-3p SPRED1 3.50132673580082 2.42716349086937e-15 -0.64004595524649 0.00626859347930208 miRNATAP -0.179812130749086 7.93557682460323e-14 NA NA NA hsa-miR-200c-3p SRF 3.50132673580082 2.42716349086937e-15 -1.54762802860391 1.84904741152095e-30 miRNATAP -0.164183916101306 6.86000844726545e-31 NA NA NA hsa-miR-200c-3p SSBP2 3.50132673580082 2.42716349086937e-15 -1.50095838408439 5.47169471767289e-08 mirMAP -0.195372913363616 1.4641661073489e-11 NA NA NA hsa-miR-200c-3p SSFA2 3.50132673580082 2.42716349086937e-15 -0.51178832437508 0.043734278908624 MirTarget -0.106538225510806 6.40312293136217e-05 NA NA NA hsa-miR-200c-3p ST3GAL2 3.50132673580082 2.42716349086937e-15 -0.445772259800494 0.0300266062096944 MirTarget;miRNATAP -0.230409451920264 3.75845543120383e-30 NA NA NA hsa-miR-200c-3p ST6GAL2 3.50132673580082 2.42716349086937e-15 -1.3142379434542 0.0257348756173388 mirMAP -0.261766619296355 2.3628803892543e-05 NA NA NA hsa-miR-200c-3p ST8SIA2 3.50132673580082 2.42716349086937e-15 1.00416696041788 0.0930911785259641 mirMAP -0.213312503342201 0.000707863570829797 NA NA NA hsa-miR-200c-3p STARD8 3.50132673580082 2.42716349086937e-15 -1.75930604958348 9.33516853968586e-11 mirMAP -0.379204663888607 9.45016942553162e-48 NA NA NA hsa-miR-200c-3p SULF1 3.50132673580082 2.42716349086937e-15 0.171691676108908 0.757613998121678 MirTarget;miRNATAP -0.49902968093352 7.30785365573536e-19 NA NA NA hsa-miR-200c-3p SV2B 3.50132673580082 2.42716349086937e-15 -2.33341367960543 7.07116491599061e-05 mirMAP -0.600923702564399 2.71705555424813e-24 NA NA NA hsa-miR-200c-3p SYDE1 3.50132673580082 2.42716349086937e-15 -0.810810064122849 0.0022212919239998 MirTarget;miRNATAP -0.364874012707535 2.34902550550674e-48 NA NA NA hsa-miR-200c-3p SYNC 3.50132673580082 2.42716349086937e-15 -0.957409925380232 0.0645528551303327 MirTarget -0.270682536919566 5.75769267580588e-07 NA NA NA hsa-miR-200c-3p SYT11 3.50132673580082 2.42716349086937e-15 -2.11616848018482 5.62916826382274e-11 mirMAP -0.470440774817395 4.40014158696989e-53 NA NA NA hsa-miR-200c-3p TBX18 3.50132673580082 2.42716349086937e-15 -2.20112491662338 0.00124808322159382 MirTarget -0.476341627053578 1.65785424624472e-11 NA NA NA hsa-miR-200c-3p TCF4 3.50132673580082 2.42716349086937e-15 -1.61270531688003 6.6047419057989e-09 mirMAP;miRNATAP -0.315861779424697 8.06031609720187e-30 NA NA NA hsa-miR-200c-3p TCF7L1 3.50132673580082 2.42716349086937e-15 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.321512044267134 2.09544895880279e-19 NA NA NA hsa-miR-200c-3p TCP11L1 3.50132673580082 2.42716349086937e-15 -0.403764783267501 0.0968250910404959 MirTarget -0.241285719807731 3.40514116790965e-23 NA NA NA hsa-miR-200c-3p TEAD1 3.50132673580082 2.42716349086937e-15 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.192783618175601 7.30243782570054e-20 NA NA NA hsa-miR-200c-3p TES 3.50132673580082 2.42716349086937e-15 -1.08685329583047 1.15308429217781e-07 MirTarget -0.119205847148141 3.61522992706086e-08 NA NA NA hsa-miR-200c-3p TFEC 3.50132673580082 2.42716349086937e-15 0.01663444290745 0.970577333140702 MirTarget -0.381763051019323 8.25525605424634e-17 NA NA NA hsa-miR-200c-3p TFPI 3.50132673580082 2.42716349086937e-15 -1.31178861447988 0.000159567700514258 MirTarget -0.206080737807578 1.47781165026496e-08 NA NA NA hsa-miR-200c-3p THEMIS 3.50132673580082 2.42716349086937e-15 -1.30669866510856 0.0118699940008927 mirMAP -0.306491960115639 1.52135462691567e-08 NA NA NA hsa-miR-200c-3p THRA 3.50132673580082 2.42716349086937e-15 -1.80486534711542 1.86472212451361e-16 mirMAP -0.221707189223359 2.68678169555829e-22 NA NA NA hsa-miR-200c-3p TIMP2 3.50132673580082 2.42716349086937e-15 -1.7485334269093 7.3578966378154e-06 miRTarBase -0.476890623570835 8.82517913264524e-36 NA NA NA hsa-miR-200c-3p TLN1 3.50132673580082 2.42716349086937e-15 -1.45515106009239 3.18740725534339e-16 miRNATAP -0.28504098114337 3.94646937052157e-66 NA NA NA hsa-miR-200c-3p TLN2 3.50132673580082 2.42716349086937e-15 -1.13678695432202 2.37164982459728e-06 miRNATAP -0.138116523337088 5.16279101952154e-08 NA NA NA hsa-miR-200c-3p TMEM170B 3.50132673580082 2.42716349086937e-15 -0.889417316317811 0.00246966185092237 miRNATAP -0.128416783647493 3.31261227696871e-05 NA NA NA hsa-miR-200c-3p TNFRSF11B 3.50132673580082 2.42716349086937e-15 0.521283699352378 0.32045562869016 miRNATAP -0.251159746127495 4.76271904987642e-06 NA NA NA hsa-miR-200c-3p TRIL 3.50132673580082 2.42716349086937e-15 -1.46802493073098 2.0969564350264e-05 MirTarget -0.296795562953484 5.36511563035758e-17 NA NA NA hsa-miR-200c-3p TRIM44 3.50132673580082 2.42716349086937e-15 -0.65549929625214 0.0026112531188157 MirTarget -0.148947024228969 4.02379735360466e-11 NA NA NA hsa-miR-200c-3p TSC22D1 3.50132673580082 2.42716349086937e-15 -1.75361245196073 6.61831957327972e-18 MirTarget;miRNATAP -0.127542242232715 6.8318793631812e-09 NA NA NA hsa-miR-200c-3p TUBB2A 3.50132673580082 2.42716349086937e-15 -0.677785072656842 0.0628952222897361 MirTarget;miRNATAP -0.301714284442487 4.90632032076582e-16 NA NA NA hsa-miR-200c-3p TUBB3 3.50132673580082 2.42716349086937e-15 2.12658714594088 1.45483266022161e-07 miRNAWalker2_validate;miRTarBase -0.103328819446613 0.0171800160429241 23074172;23394580 miR-200c increases sensitivity to taxanes in vitro by targeting class III β-tubulin gene TUBB3 a tubulin known to mediate chemoresistance;This study assessed the role of miR-200c as regulator of class III β-tubulin TUBB3 a factor associated with drug-resistance and poor prognosis in ovarian cancer; Crosslinking-coupled affinity purification method and ribonucleic-immunoprecipitation assay were used to characterise the complexes between miR-200c HuR and 3'UTR region of TUBB3 mRNA; Nanofluidic technology and immunohistochemistry were used to analyze the expression of HuR TUBB3 and miR-200c in 220 ovarian cancer patients; In A2780 cells miR-200c targeted TUBB3 3'UTR while a positive correlation was observed between miR-200c and TUBB3 expression in most of the other cell lines; This study suggests a model for the combined regulatory activity of miR-200c and HuR on TUBB3 expression in ovarian cancer drug resistance;worse prognosis;drug resistance ovarian cancer;ovarian cancer hsa-miR-200c-3p VASH1 3.50132673580082 2.42716349086937e-15 -0.337969458904786 0.116732741160964 MirTarget;miRNATAP -0.240437294328506 6.72808562672583e-30 NA NA NA hsa-miR-200c-3p VAT1L 3.50132673580082 2.42716349086937e-15 -1.21093342860372 0.00422286393153055 MirTarget;miRNATAP -0.302839487155164 4.55742927477905e-12 NA NA NA hsa-miR-200c-3p VLDLR 3.50132673580082 2.42716349086937e-15 -1.24679016115614 0.000599286809743815 miRNATAP -0.181156675550554 2.12066097629121e-06 NA NA NA hsa-miR-200c-3p WASF3 3.50132673580082 2.42716349086937e-15 -1.29629914639685 0.000157361069159746 miRNATAP -0.125405782043077 0.000560608863782371 NA NA NA hsa-miR-200c-3p WIPF1 3.50132673580082 2.42716349086937e-15 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.423943530965805 5.3342529515542e-46 NA NA NA hsa-miR-200c-3p WWC3 3.50132673580082 2.42716349086937e-15 -0.363513383213509 0.0875393935590409 MirTarget;miRNATAP -0.151520683382364 4.5850235687298e-12 NA NA NA hsa-miR-200c-3p XG 3.50132673580082 2.42716349086937e-15 -0.480004516902474 0.430428286478353 MirTarget -0.162986926918824 0.0111722348707166 NA NA NA hsa-miR-200c-3p YAP1 3.50132673580082 2.42716349086937e-15 -0.819514922156015 7.72909626929227e-05 MirTarget -0.104660951992012 1.60861074970143e-06 NA NA NA hsa-miR-200c-3p ZCCHC24 3.50132673580082 2.42716349086937e-15 -2.70719377368971 1.38525107553668e-17 MirTarget;miRNATAP -0.469547451027985 6.2189554143374e-53 NA NA NA hsa-miR-200c-3p ZDHHC15 3.50132673580082 2.42716349086937e-15 -2.821890119317 1.80193983474815e-08 MirTarget -0.368797952315401 2.17957524144729e-12 NA NA NA hsa-miR-200c-3p ZEB1 3.50132673580082 2.42716349086937e-15 -2.59416392469398 4.19342616481451e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.486626185857263 7.57364095800154e-58 27666124;24710933;23754305;24615544;24424572;24186205;21682933;22407310;27717206;23626803 miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition ;metastasis;;metastasis;drug resistance;;;;metastasis;; lung cancer;breast cancer;kidney renal cell cancer;breast cancer;head and neck cancer;prostate cancer;breast cancer;colon cancer;breast cancer;breast cancer hsa-miR-200c-3p ZEB2 3.50132673580082 2.42716349086937e-15 -2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.505461667418299 3.51768104787574e-66 24710933;26935975;21682933;25052237;18925646;24885194 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT metastasis;metastasis;;metastasis;; breast cancer;lung squamous cell cancer;breast cancer;ovarian cancer;kidney renal cell cancer;gastric cancer hsa-miR-200c-3p ZFHX4 3.50132673580082 2.42716349086937e-15 -2.72243653694716 1.46650038380412e-06 miRNATAP -0.601417439334846 3.8300230069112e-26 NA NA NA hsa-miR-200c-3p ZFP37 3.50132673580082 2.42716349086937e-15 -0.810062916275531 0.0701924167642926 mirMAP -0.130123457665786 0.00587641944702704 NA NA NA hsa-miR-200c-3p ZFPM2 3.50132673580082 2.42716349086937e-15 -3.29884457958359 4.34537841593148e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.611029488221047 1.66969606835284e-38 NA NA NA hsa-miR-200c-3p ZNF280B 3.50132673580082 2.42716349086937e-15 -1.31579833605866 0.00759832510998532 mirMAP -0.223075615143802 1.67943626937628e-05 NA NA NA hsa-miR-200c-3p ZNF423 3.50132673580082 2.42716349086937e-15 -1.58042037965747 5.91645417503201e-05 MirTarget -0.120332911159474 0.00403100341741656 NA NA NA hsa-miR-200c-3p ZNF516 3.50132673580082 2.42716349086937e-15 -1.70455112707834 2.41525896684444e-07 mirMAP;miRNATAP -0.14419629195539 4.04656572140796e-05 NA NA NA hsa-miR-200c-3p ZNF532 3.50132673580082 2.42716349086937e-15 -0.642348594400126 0.00482300004408463 MirTarget;miRNATAP -0.180943492548472 9.78355396595791e-15 NA NA NA