miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-505-5p BCL2L1 -0.109332726329313 0.346400159841743 0.056672670469081 0.380838191246795 miRNATAP -0.108957481398792 0.000366888756795515 NA NA NA hsa-miR-149-5p CBL -1.95790336710741 8.46371715052367e-27 0.286051687884677 0.000244038986460573 MirTarget -0.10536551839846 9.99329278243541e-07 NA NA NA hsa-miR-200a-3p CBL -1.43409013664263 2.00188483717828e-20 0.286051687884677 0.000244038986460573 MirTarget;mirMAP -0.115233617299526 9.51902349611081e-06 NA NA NA hsa-miR-200b-3p CBL -1.70383252137161 2.38979336321755e-30 0.286051687884677 0.000244038986460573 MirTarget;TargetScan;mirMAP -0.12664748473719 1.2564630197778e-06 NA NA NA hsa-miR-200b-5p CBL -1.46985752435972 3.43232443788022e-27 0.286051687884677 0.000244038986460573 mirMAP -0.155028741683304 8.83049409224467e-08 NA NA NA hsa-miR-29a-3p CBL -0.431613225927952 4.10166815070288e-08 0.286051687884677 0.000244038986460573 mirMAP -0.20094778538467 0.000212156588011927 NA NA NA hsa-miR-29c-3p CBL -0.238671318446745 0.0141475322347596 0.286051687884677 0.000244038986460573 mirMAP -0.151337412729307 0.000676760695777095 NA NA NA hsa-miR-429 CBL -2.16569233119434 2.66862243626443e-37 0.286051687884677 0.000244038986460573 MirTarget;PITA;mirMAP;miRNATAP -0.129127610583882 6.13038510615429e-09 NA NA NA hsa-miR-532-3p CBL -1.759223962964 7.9077916669414e-40 0.286051687884677 0.000244038986460573 PITA;miRNATAP -0.106297651593201 0.000196704550016707 NA NA NA hsa-miR-125a-5p CBLB -0.561874059994802 7.3931856356891e-13 0.741325568161762 1.68097544876719e-21 miRanda -0.25538921591315 5.98304903571149e-06 NA NA NA hsa-miR-199a-3p CBLB -1.61607426368083 1.97964980193147e-26 0.741325568161762 1.68097544876719e-21 MirTarget;PITA -0.11814853166286 1.78609906740926e-05 NA NA NA hsa-miR-199b-3p CBLB -1.61804389801139 1.97668652730486e-26 0.741325568161762 1.68097544876719e-21 MirTarget;PITA;miRNATAP -0.118169322205032 1.73729502053879e-05 NA NA NA hsa-miR-29a-5p CBLB -0.519003718107105 1.03351148282116e-06 0.741325568161762 1.68097544876719e-21 MirTarget -0.140777150154079 0.000923813476047544 NA NA NA hsa-miR-30a-5p CBLB -0.778411951775343 2.73322451127932e-16 0.741325568161762 1.68097544876719e-21 MirTarget -0.303874530813486 1.2149521242959e-11 NA NA NA hsa-miR-30b-5p CBLB -1.18330589477119 6.8341618466966e-27 0.741325568161762 1.68097544876719e-21 MirTarget;mirMAP -0.213860753645184 1.31746819624717e-08 NA NA NA hsa-miR-30c-5p CBLB -1.08783070774238 2.02505402525786e-24 0.741325568161762 1.68097544876719e-21 MirTarget;mirMAP -0.268103660711328 4.58454122154294e-12 NA NA NA hsa-miR-30e-5p CBLB -0.0905907245198101 0.21196704484334 0.741325568161762 1.68097544876719e-21 MirTarget -0.221030192216462 0.000540481019062182 NA NA NA hsa-miR-361-5p CBLB 0.0514169367202078 0.382929376393199 0.741325568161762 1.68097544876719e-21 miRanda;mirMAP -0.250371303207064 0.00167246153640962 NA NA NA hsa-miR-664a-3p CBLB -0.019312777079624 0.825861598748857 0.741325568161762 1.68097544876719e-21 mirMAP -0.1842097009895 0.000455729120611592 NA NA NA hsa-let-7e-5p CCND1 -0.727009689927955 1.30690859412163e-11 2.13480598480786 2.71111034411853e-47 miRTarBase;miRNATAP -0.309874613270473 0.000283950841354646 NA NA NA hsa-let-7g-5p CCND1 -0.739744008507763 1.07979566264383e-14 2.13480598480786 2.71111034411853e-47 miRNATAP -0.622969784922631 1.85126618527679e-11 NA NA NA hsa-miR-106a-5p CCND1 -0.830908656792615 2.67547872901508e-10 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.425464553504269 5.26102842088565e-10 NA NA NA hsa-miR-135a-5p CCND1 -2.13422485001223 6.29449029671498e-14 2.13480598480786 2.71111034411853e-47 mirMAP -0.135832732621826 2.9303290026017e-05 NA NA NA hsa-miR-183-5p CCND1 -1.21596931064487 1.31473205758898e-08 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.374903452579708 3.93459169450664e-20 NA NA NA hsa-miR-193b-3p CCND1 -0.273325765316079 0.104328826585392 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate;miRTarBase;MirTarget -0.242980057535361 1.3298535415108e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-20b-5p CCND1 -1.30218163823367 6.87172815978149e-17 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.398854407061578 1.06454795591623e-12 NA NA NA hsa-miR-214-5p CCND1 -1.44418790803397 1.50873538772684e-16 2.13480598480786 2.71111034411853e-47 MirTarget -0.347168835410485 4.02103564566879e-12 NA NA NA hsa-miR-29a-3p CCND1 -0.431613225927952 4.10166815070288e-08 2.13480598480786 2.71111034411853e-47 mirMAP -0.939711765610188 1.68520368520268e-16 NA NA NA hsa-miR-29b-3p CCND1 -0.228125979913806 0.0271621721891603 2.13480598480786 2.71111034411853e-47 mirMAP -0.387608162335363 2.20893060555751e-05 NA NA NA hsa-miR-495-3p CCND1 -0.742293735164333 7.11373308013543e-05 2.13480598480786 2.71111034411853e-47 MirTarget -0.181526805649212 0.000432098784713278 NA NA NA hsa-miR-9-5p CCND1 -2.23538606210968 1.28143998950751e-12 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.163701601563252 7.92305196930194e-09 NA NA NA hsa-let-7e-5p CCND2 -0.727009689927955 1.30690859412163e-11 1.12254248674744 2.60370825886318e-19 miRNATAP -0.233612834039481 0.000392482925172286 NA NA NA hsa-let-7g-5p CCND2 -0.739744008507763 1.07979566264383e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.192686043584521 0.0089075831083671 NA NA NA hsa-miR-106a-5p CCND2 -0.830908656792615 2.67547872901508e-10 1.12254248674744 2.60370825886318e-19 miRNATAP -0.225423059951479 2.69299129795332e-05 NA NA NA hsa-miR-10a-3p CCND2 -1.40380922426511 3.42207767326254e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.262198638789585 6.25176630952157e-08 NA NA NA hsa-miR-10b-3p CCND2 -0.8205021989966 7.84331443044781e-21 1.12254248674744 2.60370825886318e-19 mirMAP -0.448238682535571 6.77944940531982e-09 NA NA NA hsa-miR-135a-5p CCND2 -2.13422485001223 6.29449029671498e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.131225655723756 1.33192381495194e-07 NA NA NA hsa-miR-141-3p CCND2 -5.87110686537457 1.20877726722907e-85 1.12254248674744 2.60370825886318e-19 MirTarget;TargetScan -0.139228651988037 1.29114997683213e-14 NA NA NA hsa-miR-188-5p CCND2 -1.74586655806628 1.50431624674552e-28 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.254549789518694 2.9475657150123e-09 NA NA NA hsa-miR-200a-3p CCND2 -1.43409013664263 2.00188483717828e-20 1.12254248674744 2.60370825886318e-19 MirTarget -0.212833658265287 1.19682362163716e-06 NA NA NA hsa-miR-20b-5p CCND2 -1.30218163823367 6.87172815978149e-17 1.12254248674744 2.60370825886318e-19 miRNATAP -0.259528470369076 2.90568654364943e-09 NA NA NA hsa-miR-26a-1-3p CCND2 -1.56107117111696 6.75439319582901e-15 1.12254248674744 2.60370825886318e-19 mirMAP -0.123054440828334 0.000561186412955267 NA NA NA hsa-miR-29a-3p CCND2 -0.431613225927952 4.10166815070288e-08 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.257180845680541 0.00521051024582081 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.519003718107105 1.03351148282116e-06 1.12254248674744 2.60370825886318e-19 mirMAP -0.175805947483669 0.00980240816278221 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.238671318446745 0.0141475322347596 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.244609702834514 0.0011551466386057 NA NA NA hsa-miR-3065-3p CCND2 -1.64500070417457 9.57561660036697e-16 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.15735746874687 2.91648572740269e-06 NA NA NA hsa-miR-30a-3p CCND2 -0.955360819934585 1.97009535429185e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.322061265215125 1.10079970812633e-06 NA NA NA hsa-miR-30d-3p CCND2 -0.249777194282131 0.00235356711813496 1.12254248674744 2.60370825886318e-19 mirMAP -0.528583706650002 1.57965043070812e-09 NA NA NA hsa-miR-335-5p CCND2 -2.09515619961552 1.03765771499548e-25 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.125391196936535 0.000218373131234068 NA NA NA hsa-miR-378a-3p CCND2 0.287244802401236 0.0501155019984562 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.155216456838451 0.00181246322617494 NA NA NA hsa-miR-429 CCND2 -2.16569233119434 2.66862243626443e-37 1.12254248674744 2.60370825886318e-19 miRNATAP -0.226547302813025 1.44251591184469e-09 NA NA NA hsa-miR-500a-5p CCND2 -1.28374735824553 1.95870374809798e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.227276642384328 3.82424468920894e-06 NA NA NA hsa-miR-501-5p CCND2 -1.1103073934745 1.81589804886553e-16 1.12254248674744 2.60370825886318e-19 PITA;mirMAP;miRNATAP -0.210338351972789 4.15719063926169e-05 NA NA NA hsa-miR-577 CCND2 -1.48881999472397 7.03080165111147e-10 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.106625188470732 0.000293795265070961 NA NA NA hsa-miR-660-5p CCND2 -1.20833564582661 8.48975910642834e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.376740011929223 2.58290869632093e-12 NA NA NA hsa-miR-362-3p CCND3 -0.753214251798232 3.0025661608035e-07 0.51821271483815 4.41964906922001e-09 miRanda -0.139754455099983 4.25864164139051e-05 NA NA NA hsa-miR-501-5p CCND3 -1.1103073934745 1.81589804886553e-16 0.51821271483815 4.41964906922001e-09 PITA -0.131433527243481 0.000178229069185252 NA NA NA hsa-miR-146b-5p CNTFR 1.40714170253819 2.9559871816487e-12 -3.02107255681371 1.05039478653057e-17 miRNATAP -0.404191852581092 3.41457970363321e-05 NA NA NA hsa-miR-193a-5p CNTFR 1.29777740059595 2.16815694068336e-39 -3.02107255681371 1.05039478653057e-17 TargetScan;miRNATAP -1.27433433538382 9.23601939880768e-13 NA NA NA hsa-miR-19a-3p CNTFR 0.722913586880779 2.76301458932381e-10 -3.02107255681371 1.05039478653057e-17 miRNATAP -0.62578285713391 0.000328583286421605 NA NA NA hsa-miR-21-5p CNTFR 2.51462371613332 3.30620591950316e-66 -3.02107255681371 1.05039478653057e-17 miRNATAP -0.858623113614125 4.68496779058245e-15 NA NA NA hsa-miR-361-3p CNTFR 1.08992546227594 1.13197240706704e-36 -3.02107255681371 1.05039478653057e-17 PITA;miRNATAP -1.01804915822142 1.46942111615293e-06 NA NA NA hsa-miR-589-5p CNTFR 0.696241532021631 5.26958362886071e-16 -3.02107255681371 1.05039478653057e-17 miRNATAP -0.71385319551769 0.00188112130764511 NA NA NA hsa-miR-125a-3p CSF2RA -0.372794471295036 0.000941729459601642 2.04597514627679 1.30448604285376e-34 miRanda -0.338486446311746 0.00018657364955368 NA NA NA hsa-miR-429 CSF2RA -2.16569233119434 2.66862243626443e-37 2.04597514627679 1.30448604285376e-34 miRanda -0.357237595827724 7.57318369445553e-12 NA NA NA hsa-miR-125a-5p CSF2RB -0.561874059994802 7.3931856356891e-13 1.53131879126979 1.05288331370998e-31 miRanda -0.614243689240012 2.13235884305686e-10 NA NA NA hsa-miR-30b-3p CSF2RB -1.64703050862226 1.89878531036464e-31 1.53131879126979 1.05288331370998e-31 MirTarget -0.459985158783373 2.07886560326231e-21 NA NA NA hsa-miR-532-5p CSF2RB -1.09700348358668 8.34836230254408e-26 1.53131879126979 1.05288331370998e-31 MirTarget -0.59475160408329 7.07128968939799e-19 NA NA NA hsa-miR-127-3p CSF3R -1.21389348740811 1.68387193137287e-11 2.90015123900884 1.37521986016231e-51 miRanda -0.216558952743924 0.00118112179597598 NA NA NA hsa-miR-30b-3p CSF3R -1.64703050862226 1.89878531036464e-31 2.90015123900884 1.37521986016231e-51 MirTarget -0.847675078615151 8.44876867014225e-31 NA NA NA hsa-miR-429 CSF3R -2.16569233119434 2.66862243626443e-37 2.90015123900884 1.37521986016231e-51 miRanda -0.505655126350947 6.12163686496989e-16 NA NA NA hsa-miR-185-3p CTF1 0.993379985307475 2.62011454953707e-13 -1.39160616300587 1.69960599771431e-18 MirTarget -0.26513148773884 6.18112612699336e-05 NA NA NA hsa-miR-185-5p CTF1 1.05056378692621 1.31174187880682e-22 -1.39160616300587 1.69960599771431e-18 MirTarget -0.424312944042144 9.31132478637917e-08 NA NA NA hsa-miR-342-3p CTF1 1.4124432570595 1.07208971556131e-28 -1.39160616300587 1.69960599771431e-18 miRanda -0.425522367534629 5.65103089489611e-11 NA NA NA hsa-miR-590-3p CTF1 1.13702599385212 3.53435739887793e-22 -1.39160616300587 1.69960599771431e-18 miRanda -0.355650170868006 1.13439982875998e-06 NA NA NA hsa-miR-106b-5p EP300 1.07509411417907 2.11739194181878e-36 -0.147148678710588 0.0405321000139646 miRNATAP -0.261995772265445 1.08364064661463e-10 NA NA NA hsa-miR-186-5p EP300 0.507217561043443 9.04455748270995e-10 -0.147148678710588 0.0405321000139646 miRNATAP -0.121597586405933 0.00972259491444961 NA NA NA hsa-miR-22-3p EP300 0.198460552200729 0.00761005672059428 -0.147148678710588 0.0405321000139646 MirTarget;miRNATAP -0.164572270687749 0.00217699129328605 NA NA NA hsa-miR-26b-5p EP300 -0.251437253429904 0.00270935785098697 -0.147148678710588 0.0405321000139646 miRNAWalker2_validate;miRNATAP -0.150155147849394 0.00151617840802469 NA NA NA hsa-miR-339-5p EP300 0.322848334531193 0.0117281778821612 -0.147148678710588 0.0405321000139646 miRanda -0.150136558180177 8.30541099155694e-07 NA NA NA hsa-miR-361-3p EP300 1.08992546227594 1.13197240706704e-36 -0.147148678710588 0.0405321000139646 PITA -0.124298281144442 0.00252789477423822 NA NA NA hsa-miR-362-3p EPO -0.753214251798232 3.0025661608035e-07 2.97468115359073 2.48151362453116e-09 miRanda -0.817311050765461 2.37811083324868e-05 NA NA NA hsa-let-7i-5p GHR 0.911372377723717 7.11483853341932e-31 -0.955186227006797 3.69358652414153e-08 miRNATAP -0.726049723887594 5.34447036878994e-11 NA NA NA hsa-miR-142-3p GHR 1.88928758773299 2.72985643829893e-22 -0.955186227006797 3.69358652414153e-08 MirTarget;PITA;miRanda;miRNATAP -0.176030319444075 0.000161318020245714 NA NA NA hsa-miR-15a-5p GHR 1.42663930007845 1.36006952074963e-57 -0.955186227006797 3.69358652414153e-08 MirTarget;miRNATAP -0.453849278577286 5.82863690126066e-07 NA NA NA hsa-miR-15b-5p GHR 0.773001494057531 1.71784656078957e-16 -0.955186227006797 3.69358652414153e-08 MirTarget;miRNATAP -0.478420037004111 1.26392220958e-06 NA NA NA hsa-miR-16-2-3p GHR 1.3046118743965 4.17207934608428e-19 -0.955186227006797 3.69358652414153e-08 mirMAP -0.262146870859392 2.96598397484773e-05 NA NA NA hsa-miR-590-3p GHR 1.13702599385212 3.53435739887793e-22 -0.955186227006797 3.69358652414153e-08 mirMAP -0.446832848188645 5.49046571889865e-09 NA NA NA hsa-miR-651-5p GHR 0.535144061895781 2.49922577209869e-05 -0.955186227006797 3.69358652414153e-08 MirTarget -0.230389461869185 0.00447721652840496 NA NA NA hsa-miR-361-5p IFNAR1 0.0514169367202078 0.382929376393199 0.10514317996324 0.0682297745500082 miRanda -0.146184449914313 0.0080804723406082 NA NA NA hsa-miR-127-3p IFNAR2 -1.21389348740811 1.68387193137287e-11 1.16163195463252 4.6258503785108e-45 miRanda -0.116929066097904 2.77439915963308e-05 NA NA NA hsa-miR-141-3p IFNAR2 -5.87110686537457 1.20877726722907e-85 1.16163195463252 4.6258503785108e-45 mirMAP -0.146849625744503 1.35924303965125e-33 NA NA NA hsa-miR-200a-3p IFNAR2 -1.43409013664263 2.00188483717828e-20 1.16163195463252 4.6258503785108e-45 mirMAP -0.12172532928145 0.000119081739660449 NA NA NA hsa-miR-125a-5p IFNG -0.561874059994802 7.3931856356891e-13 3.51273030940594 6.90823329182531e-31 miRanda -1.81569033041406 1.48248099203258e-16 NA NA NA hsa-miR-429 IFNG -2.16569233119434 2.66862243626443e-37 3.51273030940594 6.90823329182531e-31 miRanda -0.668635227601934 9.8297311127528e-13 NA NA NA hsa-miR-577 IFNG -1.48881999472397 7.03080165111147e-10 3.51273030940594 6.90823329182531e-31 mirMAP -0.290083530575535 9.677189287566e-05 NA NA NA hsa-miR-362-3p IFNGR1 -0.753214251798232 3.0025661608035e-07 0.677251763112078 9.05904787347525e-23 miRanda -0.170292726288099 5.25138078651637e-10 NA NA NA hsa-miR-429 IFNGR1 -2.16569233119434 2.66862243626443e-37 0.677251763112078 9.05904787347525e-23 miRNATAP -0.144416765077269 2.68104746019572e-12 NA NA NA hsa-miR-1296-5p IFNGR2 -0.992767487650773 3.35721559985878e-13 1.06928160079585 7.80830266493445e-43 miRNAWalker2_validate -0.208670079320118 8.62201243031111e-10 NA NA NA hsa-miR-429 IFNGR2 -2.16569233119434 2.66862243626443e-37 1.06928160079585 7.80830266493445e-43 miRanda -0.197009002471902 1.41006822569539e-15 NA NA NA hsa-let-7e-5p IL10 -0.727009689927955 1.30690859412163e-11 1.34763354397764 4.94531527271055e-10 miRNATAP -0.413434492276061 0.000188227396547362 NA NA NA hsa-miR-125a-3p IL10 -0.372794471295036 0.000941729459601642 1.34763354397764 4.94531527271055e-10 MirTarget;PITA;miRanda;miRNATAP -0.329372514344239 0.00248581370363676 NA NA NA hsa-miR-27b-3p IL10 -0.699527231242518 1.07356023759234e-15 1.34763354397764 4.94531527271055e-10 miRNATAP -0.7738052333091 5.87390577954409e-09 NA NA NA hsa-miR-125a-5p IL10RA -0.561874059994802 7.3931856356891e-13 2.35153430025014 1.16617113153383e-43 miRanda -1.13163001028525 4.39612795860591e-19 NA NA NA hsa-miR-140-5p IL11 0.504309496243674 3.09884038729031e-11 -3.93964044852308 8.18194360115285e-39 miRanda -1.1514314076294 1.80180137110324e-06 NA NA NA hsa-miR-142-3p IL11 1.88928758773299 2.72985643829893e-22 -3.93964044852308 8.18194360115285e-39 miRanda -0.522917648155842 3.64075975234069e-09 NA NA NA hsa-miR-23a-3p IL11 0.761438723382355 4.09310879199257e-27 -3.93964044852308 8.18194360115285e-39 miRNATAP -1.49707774559431 7.70932470562927e-10 NA NA NA hsa-miR-361-3p IL11 1.08992546227594 1.13197240706704e-36 -3.93964044852308 8.18194360115285e-39 MirTarget -1.32643659928765 3.44114008975197e-12 NA NA NA hsa-miR-616-5p IL11 0.913426384742148 3.78418389333709e-09 -3.93964044852308 8.18194360115285e-39 mirMAP -0.455864080242044 0.000150037477466221 NA NA NA hsa-miR-193a-3p IL11RA 0.849206638484406 3.68101781083335e-14 -0.416691629009418 0.000277681158915473 miRanda -0.247100460602685 5.29242132943475e-06 NA NA NA hsa-miR-326 IL11RA 0.0283498662828876 0.83943976716391 -0.416691629009418 0.000277681158915473 miRanda -0.160587628588575 0.000418620224945825 NA NA NA hsa-miR-330-5p IL11RA 1.44960468659754 2.12131210588035e-45 -0.416691629009418 0.000277681158915473 miRanda -0.312884607634035 3.48049104238053e-09 NA NA NA hsa-miR-125a-5p IL12RB2 -0.561874059994802 7.3931856356891e-13 0.863770648033775 0.00803518728511301 miRanda -0.651992213020629 0.00369450562730367 NA NA NA hsa-miR-199a-5p IL12RB2 -1.64658415208633 1.01615659358973e-23 0.863770648033775 0.00803518728511301 miRanda -0.358371129282876 0.000438990729550452 NA NA NA hsa-miR-199b-5p IL12RB2 -2.39483476763681 1.04659509514884e-17 0.863770648033775 0.00803518728511301 miRanda -0.173161339742671 0.00566686046020428 NA NA NA hsa-let-7e-3p IL13RA1 -0.988846910331566 1.46631671208881e-18 0.155699202384092 0.0205783270435822 MirTarget -0.121568937491927 9.0703073500467e-05 NA NA NA hsa-miR-361-5p IL13RA1 0.0514169367202078 0.382929376393199 0.155699202384092 0.0205783270435822 miRanda -0.198051753302095 0.00212209575503206 NA NA NA hsa-miR-130a-3p IL15 -0.667386596699886 1.34029167767774e-10 0.837916006433949 2.57016399328188e-16 MirTarget -0.201076415386713 0.000281578691062943 NA NA NA hsa-miR-139-5p IL15 -0.704802495091118 2.36904108453776e-06 0.837916006433949 2.57016399328188e-16 miRanda -0.128880941563601 0.000942686122514287 NA NA NA hsa-miR-429 IL15 -2.16569233119434 2.66862243626443e-37 0.837916006433949 2.57016399328188e-16 miRanda -0.155631216226153 3.56832525354193e-07 NA NA NA hsa-miR-493-5p IL15 -1.03936667688502 3.71842205277243e-08 0.837916006433949 2.57016399328188e-16 MirTarget -0.109347146838506 0.000537907025258782 NA NA NA hsa-miR-125a-5p IL15RA -0.561874059994802 7.3931856356891e-13 1.3593689707392 1.11219802521041e-28 miRanda -0.551835963011766 7.96744651089317e-10 NA NA NA hsa-miR-199a-5p IL15RA -1.64658415208633 1.01615659358973e-23 1.3593689707392 1.11219802521041e-28 miRanda -0.173500906275958 2.93108425667489e-05 NA NA NA hsa-miR-140-5p IL20RA 0.504309496243674 3.09884038729031e-11 -3.3952594341058 1.20142242865088e-26 miRanda -1.0968229475327 7.02237355365526e-06 NA NA NA hsa-miR-338-3p IL20RA 0.906250377628867 2.76970900371139e-15 -3.3952594341058 1.20142242865088e-26 miRanda -1.1317641222043 1.94405275277206e-13 NA NA NA hsa-miR-374a-5p IL20RA 0.543061152108237 2.19403097299769e-14 -3.3952594341058 1.20142242865088e-26 mirMAP -0.942766932800161 0.000286020271151037 NA NA NA hsa-miR-452-5p IL20RA 2.05325688842141 2.82238393643084e-40 -3.3952594341058 1.20142242865088e-26 miRNATAP -0.732495363644953 3.59274793465671e-12 NA NA NA hsa-miR-590-3p IL20RA 1.13702599385212 3.53435739887793e-22 -3.3952594341058 1.20142242865088e-26 miRanda;mirMAP -0.60205128287395 7.04656841036883e-05 NA NA NA hsa-miR-7-1-3p IL20RA 0.544601828025304 5.33830451326047e-07 -3.3952594341058 1.20142242865088e-26 MirTarget -0.56762572896948 0.00102858866124101 NA NA NA hsa-miR-125a-3p IL20RB -0.372794471295036 0.000941729459601642 4.44325193042914 5.57513261881538e-30 miRanda -0.891354187104024 1.9036716179904e-05 NA NA NA hsa-miR-199a-5p IL20RB -1.64658415208633 1.01615659358973e-23 4.44325193042914 5.57513261881538e-30 miRanda -0.49753367076058 0.000197091548089457 NA NA NA hsa-miR-199a-5p IL21R -1.64658415208633 1.01615659358973e-23 2.59385524034444 2.56131325054988e-39 miRanda -0.216962895154717 0.00191885005988628 NA NA NA hsa-miR-24-1-5p IL21R -1.09236439756236 3.27091225010919e-23 2.59385524034444 2.56131325054988e-39 MirTarget -0.622027554519886 1.35426040288754e-09 NA NA NA hsa-miR-335-5p IL21R -2.09515619961552 1.03765771499548e-25 2.59385524034444 2.56131325054988e-39 miRNAWalker2_validate -0.256635868056657 6.9147994553104e-06 NA NA NA hsa-miR-125a-5p IL22RA1 -0.561874059994802 7.3931856356891e-13 1.36605388121269 3.28200692112111e-08 miRanda -1.14240830185066 1.21357030738086e-11 NA NA NA hsa-miR-3065-3p IL2RA -1.64500070417457 9.57561660036697e-16 2.10873252704572 9.99428856889031e-18 MirTarget -0.344433151078364 1.55794209180431e-07 NA NA NA hsa-miR-500a-3p IL2RA -1.41379327701944 2.73403824528455e-37 2.10873252704572 9.99428856889031e-18 MirTarget -0.689805364156805 9.4316685114978e-10 NA NA NA hsa-miR-125a-5p IL2RB -0.561874059994802 7.3931856356891e-13 3.3475085815016 3.78227657279626e-65 miRanda -1.32471955838635 4.85701489011067e-17 NA NA NA hsa-miR-139-5p IL2RB -0.704802495091118 2.36904108453776e-06 3.3475085815016 3.78227657279626e-65 miRanda -0.437746244840167 4.32946589039136e-07 NA NA NA hsa-miR-30b-3p IL2RB -1.64703050862226 1.89878531036464e-31 3.3475085815016 3.78227657279626e-65 mirMAP -0.8721459102493 2.46203627751483e-28 NA NA NA hsa-miR-362-3p IL3RA -0.753214251798232 3.0025661608035e-07 1.61131969334758 1.96984916616799e-32 miRanda -0.289330502310158 3.01527391899967e-07 NA NA NA hsa-miR-125a-3p IL4R -0.372794471295036 0.000941729459601642 1.49677954940201 5.82824628338837e-49 miRanda -0.159706515114085 0.00599147791408276 NA NA NA hsa-miR-199a-5p IL4R -1.64658415208633 1.01615659358973e-23 1.49677954940201 5.82824628338837e-49 miRNATAP -0.165451960039341 6.80976697584275e-06 NA NA NA hsa-miR-429 IL4R -2.16569233119434 2.66862243626443e-37 1.49677954940201 5.82824628338837e-49 miRNATAP -0.279597082387011 1.10779269370854e-17 NA NA NA hsa-miR-107 IL6 0.140046250553248 0.0943611632552367 -0.432551704985806 0.174200627733491 miRanda -0.626802809840839 0.00308751628926532 NA NA NA hsa-miR-139-5p IL6 -0.704802495091118 2.36904108453776e-06 -0.432551704985806 0.174200627733491 miRanda -0.314265848732322 0.00673546049087722 NA NA NA hsa-miR-338-5p IL6 0.628429807914222 1.27575140717947e-06 -0.432551704985806 0.174200627733491 MirTarget;PITA -0.580992506147854 1.66390019671047e-05 NA NA NA hsa-let-7e-5p IL6R -0.727009689927955 1.30690859412163e-11 0.972862618334167 1.56964143104202e-11 miRNATAP -0.252752871810542 0.000660501453991924 NA NA NA hsa-let-7g-5p IL6R -0.739744008507763 1.07979566264383e-14 0.972862618334167 1.56964143104202e-11 miRNATAP -0.239374174285825 0.00384605528970956 NA NA NA hsa-miR-125a-5p IL6R -0.561874059994802 7.3931856356891e-13 0.972862618334167 1.56964143104202e-11 MirTarget;miRanda -0.322679083593268 0.00159012681584773 NA NA NA hsa-miR-125b-5p IL6R -0.825456421494266 2.13029877878434e-15 0.972862618334167 1.56964143104202e-11 miRTarBase;MirTarget -0.31503876661173 2.89797058763512e-05 22942733 The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R progression liver cancer hsa-miR-130a-3p IL6R -0.667386596699886 1.34029167767774e-10 0.972862618334167 1.56964143104202e-11 mirMAP -0.355333608036724 3.34709945184669e-06 NA NA NA hsa-miR-135b-5p IL6R -1.12731059106515 6.06922867778145e-08 0.972862618334167 1.56964143104202e-11 mirMAP -0.192801757765878 5.32192209374102e-07 NA NA NA hsa-miR-141-3p IL6R -5.87110686537457 1.20877726722907e-85 0.972862618334167 1.56964143104202e-11 MirTarget -0.168219437994158 7.67162387417505e-17 NA NA NA hsa-miR-182-5p IL6R -0.608710746044567 0.0025264935278104 0.972862618334167 1.56964143104202e-11 mirMAP -0.209060391288049 1.66329321365e-07 NA NA NA hsa-miR-193b-3p IL6R -0.273325765316079 0.104328826585392 0.972862618334167 1.56964143104202e-11 mirMAP -0.143100304242552 0.00338313506548892 NA NA NA hsa-miR-29a-5p IL6R -0.519003718107105 1.03351148282116e-06 0.972862618334167 1.56964143104202e-11 mirMAP -0.309163432959387 4.77671025101178e-05 NA NA NA hsa-miR-30b-5p IL6R -1.18330589477119 6.8341618466966e-27 0.972862618334167 1.56964143104202e-11 mirMAP -0.180519271686128 0.00882857209665063 NA NA NA hsa-miR-335-5p IL6R -2.09515619961552 1.03765771499548e-25 0.972862618334167 1.56964143104202e-11 mirMAP -0.192465311053153 3.59665460891334e-07 NA NA NA hsa-miR-33a-5p IL6R -1.59840463890997 1.13487952314403e-18 0.972862618334167 1.56964143104202e-11 mirMAP -0.131237784810567 0.00229977004142412 NA NA NA hsa-let-7a-3p IL6ST 0.0677487960013088 0.460458477653989 -0.830214354466655 4.20460543551165e-06 mirMAP -0.388918607391424 0.000443606720195524 NA NA NA hsa-let-7f-1-3p IL6ST 0.477913872379336 4.46669616865068e-05 -0.830214354466655 4.20460543551165e-06 mirMAP -0.265931516271198 0.0041385567026575 NA NA NA hsa-miR-103a-3p IL6ST 0.779373475434461 7.37867196796994e-20 -0.830214354466655 4.20460543551165e-06 mirMAP -0.42170281717112 0.000159977328299306 NA NA NA hsa-miR-130b-3p IL6ST 1.12788913578446 2.939369462276e-16 -0.830214354466655 4.20460543551165e-06 miRNATAP -0.369808918753679 7.84698690786665e-08 NA NA NA hsa-miR-155-5p IL6ST 3.26274490570809 5.06841441826518e-51 -0.830214354466655 4.20460543551165e-06 mirMAP -0.146237163760128 0.000203208849176121 NA NA NA hsa-miR-16-1-3p IL6ST 1.51429140700091 3.17219833254498e-37 -0.830214354466655 4.20460543551165e-06 mirMAP -0.220347679899102 0.00419415257616664 NA NA NA hsa-miR-16-2-3p IL6ST 1.3046118743965 4.17207934608428e-19 -0.830214354466655 4.20460543551165e-06 mirMAP -0.229244835423358 0.000427748334146851 NA NA NA hsa-miR-181a-5p IL6ST 1.11111114875339 3.97880443756442e-29 -0.830214354466655 4.20460543551165e-06 mirMAP -0.296154497539728 0.00150118739044309 NA NA NA hsa-miR-181b-5p IL6ST 1.49054296272357 3.69051660739368e-41 -0.830214354466655 4.20460543551165e-06 mirMAP -0.317634507821758 6.76808882958407e-05 NA NA NA hsa-miR-19a-3p IL6ST 0.722913586880779 2.76301458932381e-10 -0.830214354466655 4.20460543551165e-06 mirMAP;miRNATAP -0.314671203609016 0.000239266037494611 NA NA NA hsa-miR-19b-3p IL6ST 0.195940928879427 0.0300512922542325 -0.830214354466655 4.20460543551165e-06 mirMAP;miRNATAP -0.429928012792196 0.00012360014855718 NA NA NA hsa-miR-21-5p IL6ST 2.51462371613332 3.30620591950316e-66 -0.830214354466655 4.20460543551165e-06 mirMAP -0.282405430241018 3.37749932817188e-07 NA NA NA hsa-miR-223-3p IL6ST 1.23291409735619 1.07767240442694e-17 -0.830214354466655 4.20460543551165e-06 MirTarget -0.270336184842012 4.36545224718977e-05 NA NA NA hsa-miR-2355-3p IL6ST 1.32757890426926 1.88016636795886e-18 -0.830214354466655 4.20460543551165e-06 MirTarget;miRNATAP -0.258316387996007 6.01908860284068e-05 NA NA NA hsa-miR-361-5p IL6ST 0.0514169367202078 0.382929376393199 -0.830214354466655 4.20460543551165e-06 mirMAP -0.456900544946516 0.00951493626915792 NA NA NA hsa-miR-362-3p IL6ST -0.753214251798232 3.0025661608035e-07 -0.830214354466655 4.20460543551165e-06 PITA;miRanda;miRNATAP -0.186953038067759 0.00733062027271063 NA NA NA hsa-miR-452-5p IL6ST 2.05325688842141 2.82238393643084e-40 -0.830214354466655 4.20460543551165e-06 mirMAP -0.200691356933389 0.00046837064266299 NA NA NA hsa-miR-455-5p IL6ST 0.773674551205946 2.12957541541474e-09 -0.830214354466655 4.20460543551165e-06 miRanda -0.255188998836547 0.000808232098092078 NA NA NA hsa-miR-590-3p IL6ST 1.13702599385212 3.53435739887793e-22 -0.830214354466655 4.20460543551165e-06 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.36436029283773 5.16296570346e-06 NA NA NA hsa-miR-590-5p IL6ST 0.709763558412506 1.11883921359361e-11 -0.830214354466655 4.20460543551165e-06 mirMAP -0.347745082703365 0.000200880828513706 NA NA NA hsa-miR-625-3p IL6ST 1.09679549288964 4.60800634006165e-20 -0.830214354466655 4.20460543551165e-06 mirMAP -0.272150283669029 0.000613528979933243 NA NA NA hsa-miR-125a-3p IL7 -0.372794471295036 0.000941729459601642 1.13806384776766 2.49308081070627e-22 miRanda -0.280128044841504 3.94356967379565e-06 NA NA NA hsa-miR-335-3p IL7 -1.36498175550207 6.84287752180534e-13 1.13806384776766 2.49308081070627e-22 mirMAP -0.103522186738094 0.00316757210475103 NA NA NA hsa-miR-335-5p IL7 -2.09515619961552 1.03765771499548e-25 1.13806384776766 2.49308081070627e-22 miRNAWalker2_validate -0.164678918721996 2.202357769123e-07 NA NA NA hsa-miR-429 IL7 -2.16569233119434 2.66862243626443e-37 1.13806384776766 2.49308081070627e-22 miRanda -0.266134283710059 2.28778200379979e-14 NA NA NA hsa-miR-125a-5p IL7R -0.561874059994802 7.3931856356891e-13 1.60171759676547 2.18199799378877e-10 miRanda -0.659685143855203 0.000203244531868886 NA NA NA hsa-miR-501-5p IL7R -1.1103073934745 1.81589804886553e-16 1.60171759676547 2.18199799378877e-10 mirMAP -0.289151794747211 0.00432536351288238 NA NA NA hsa-miR-30b-5p JAK1 -1.18330589477119 6.8341618466966e-27 0.131794605189519 0.0301816038641141 MirTarget -0.154327762699697 1.98242713979809e-08 NA NA NA hsa-miR-139-5p JAK3 -0.704802495091118 2.36904108453776e-06 2.48026307004137 8.08540877822019e-45 miRanda -0.608452589439119 5.99295126216892e-18 NA NA NA hsa-miR-30b-3p JAK3 -1.64703050862226 1.89878531036464e-31 2.48026307004137 8.08540877822019e-45 MirTarget -0.801091421044252 1.53134081837362e-34 NA NA NA hsa-miR-335-5p JAK3 -2.09515619961552 1.03765771499548e-25 2.48026307004137 8.08540877822019e-45 miRNAWalker2_validate -0.228223837966963 1.09784040689687e-05 NA NA NA hsa-let-7a-3p LEPR 0.0677487960013088 0.460458477653989 -0.713388995285893 1.17652694467769e-09 mirMAP -0.217872701634634 0.00282056705820898 NA NA NA hsa-miR-107 LEPR 0.140046250553248 0.0943611632552367 -0.713388995285893 1.17652694467769e-09 miRanda -0.329705568329651 3.38678484065518e-05 NA NA NA hsa-miR-130b-5p LEPR 0.92990617673277 3.75880436852717e-12 -0.713388995285893 1.17652694467769e-09 mirMAP -0.158236393167947 0.000945190949528951 NA NA NA hsa-miR-16-1-3p LEPR 1.51429140700091 3.17219833254498e-37 -0.713388995285893 1.17652694467769e-09 mirMAP -0.198979933862925 7.58550578291191e-05 NA NA NA hsa-miR-16-2-3p LEPR 1.3046118743965 4.17207934608428e-19 -0.713388995285893 1.17652694467769e-09 mirMAP -0.159270281394924 0.000192801790601147 NA NA NA hsa-miR-330-5p LEPR 1.44960468659754 2.12131210588035e-45 -0.713388995285893 1.17652694467769e-09 miRanda -0.163037700395948 0.00378822516534066 NA NA NA hsa-miR-342-3p LEPR 1.4124432570595 1.07208971556131e-28 -0.713388995285893 1.17652694467769e-09 miRanda -0.209839723802661 9.59946543517125e-06 NA NA NA hsa-miR-590-3p LEPR 1.13702599385212 3.53435739887793e-22 -0.713388995285893 1.17652694467769e-09 miRanda;mirMAP -0.25543879573083 1.09484871859878e-06 NA NA NA hsa-miR-590-5p LEPR 0.709763558412506 1.11883921359361e-11 -0.713388995285893 1.17652694467769e-09 miRanda -0.220843217504967 0.000330063348842574 NA NA NA hsa-miR-125a-5p LIF -0.561874059994802 7.3931856356891e-13 0.943241753349928 1.35810079779624e-05 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.699994193011355 2.70080462545203e-06 25962054 MicroRNA 125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway breast cancer hsa-miR-125b-5p LIF -0.825456421494266 2.13029877878434e-15 0.943241753349928 1.35810079779624e-05 miRNAWalker2_validate;mirMAP -0.337932456675289 0.00248857574101006 NA NA NA hsa-miR-141-3p LIF -5.87110686537457 1.20877726722907e-85 0.943241753349928 1.35810079779624e-05 mirMAP -0.123173820969062 6.94731137879578e-05 NA NA NA hsa-miR-200a-3p LIF -1.43409013664263 2.00188483717828e-20 0.943241753349928 1.35810079779624e-05 mirMAP -0.224639217334264 0.0022323243998647 NA NA NA hsa-miR-204-5p LIF -1.67490789640238 9.14741888352476e-10 0.943241753349928 1.35810079779624e-05 mirMAP -0.235354317857823 2.61895372066696e-08 NA NA NA hsa-miR-20b-5p LIF -1.30218163823367 6.87172815978149e-17 0.943241753349928 1.35810079779624e-05 miRNATAP -0.207547591726593 0.00504959501885434 NA NA NA hsa-miR-30c-2-3p LIF -1.28402709024345 6.77577627955178e-25 0.943241753349928 1.35810079779624e-05 mirMAP -0.579615222126915 4.05309582547518e-11 NA NA NA hsa-miR-532-3p LIF -1.759223962964 7.9077916669414e-40 0.943241753349928 1.35810079779624e-05 mirMAP -0.557966154317305 6.97382267425004e-13 NA NA NA hsa-miR-577 LIF -1.48881999472397 7.03080165111147e-10 0.943241753349928 1.35810079779624e-05 mirMAP -0.210604751394277 1.48069734072017e-05 NA NA NA hsa-let-7a-3p LIFR 0.0677487960013088 0.460458477653989 -0.846118355938462 2.2628560201304e-11 mirMAP -0.312749965151964 7.16222513535689e-05 NA NA NA hsa-let-7f-1-3p LIFR 0.477913872379336 4.46669616865068e-05 -0.846118355938462 2.2628560201304e-11 mirMAP -0.251016108838399 0.000137174227243121 NA NA NA hsa-miR-1271-5p LIFR 0.900599702972936 3.07963385418853e-10 -0.846118355938462 2.2628560201304e-11 mirMAP -0.126393873207439 0.00997370858571378 NA NA NA hsa-miR-142-3p LIFR 1.88928758773299 2.72985643829893e-22 -0.846118355938462 2.2628560201304e-11 miRNATAP -0.19958057909419 3.65746263193117e-09 NA NA NA hsa-miR-142-5p LIFR 1.88417391525707 1.2096808039882e-27 -0.846118355938462 2.2628560201304e-11 PITA;mirMAP -0.265037737717989 7.38886082719864e-13 NA NA NA hsa-miR-182-5p LIFR -0.608710746044567 0.0025264935278104 -0.846118355938462 2.2628560201304e-11 mirMAP -0.145659589380116 3.62475343806933e-05 NA NA NA hsa-miR-186-5p LIFR 0.507217561043443 9.04455748270995e-10 -0.846118355938462 2.2628560201304e-11 mirMAP -0.235241467002862 0.00600028001939844 NA NA NA hsa-miR-19a-3p LIFR 0.722913586880779 2.76301458932381e-10 -0.846118355938462 2.2628560201304e-11 mirMAP -0.241304536669052 7.61860429190518e-05 NA NA NA hsa-miR-19b-3p LIFR 0.195940928879427 0.0300512922542325 -0.846118355938462 2.2628560201304e-11 mirMAP -0.344891069994759 1.48425273959768e-05 NA NA NA hsa-miR-21-5p LIFR 2.51462371613332 3.30620591950316e-66 -0.846118355938462 2.2628560201304e-11 miRNAWalker2_validate -0.398090356043318 4.17018874952896e-27 NA NA NA hsa-miR-221-3p LIFR 0.337895669520713 0.0136448974691037 -0.846118355938462 2.2628560201304e-11 miRNATAP -0.313947403341103 9.73420337564233e-10 NA NA NA hsa-miR-222-3p LIFR 0.214811008033524 0.0965295551752457 -0.846118355938462 2.2628560201304e-11 miRNATAP -0.300426094378205 4.47022326646035e-08 NA NA NA hsa-miR-23a-3p LIFR 0.761438723382355 4.09310879199257e-27 -0.846118355938462 2.2628560201304e-11 mirMAP -0.451363519775348 1.55546110089738e-06 NA NA NA hsa-miR-27a-3p LIFR 0.558934437526245 1.44256383086177e-12 -0.846118355938462 2.2628560201304e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.527542932372132 1.38688923525782e-09 NA NA NA hsa-miR-320a LIFR 0.412740558379182 2.02929519701706e-05 -0.846118355938462 2.2628560201304e-11 miRanda -0.245817972654792 0.00086728187376636 NA NA NA hsa-miR-320b LIFR 0.300497419754843 0.0245219177384172 -0.846118355938462 2.2628560201304e-11 miRanda -0.183132269803782 0.000656531109330429 NA NA NA hsa-miR-374a-3p LIFR 1.13863935833993 2.79089304015401e-44 -0.846118355938462 2.2628560201304e-11 miRNATAP -0.405412140248253 1.04892498882523e-07 NA NA NA hsa-miR-590-3p LIFR 1.13702599385212 3.53435739887793e-22 -0.846118355938462 2.2628560201304e-11 miRanda;mirMAP -0.390263270307491 2.6985572569501e-12 NA NA NA hsa-miR-590-5p LIFR 0.709763558412506 1.11883921359361e-11 -0.846118355938462 2.2628560201304e-11 PITA;miRNATAP -0.407534077344433 4.77906332603199e-10 NA NA NA hsa-miR-616-5p LIFR 0.913426384742148 3.78418389333709e-09 -0.846118355938462 2.2628560201304e-11 mirMAP -0.160689536861066 0.000474018413942707 NA NA NA hsa-miR-629-3p LIFR 1.09330044556689 2.9533160808356e-14 -0.846118355938462 2.2628560201304e-11 miRNATAP -0.161695690984964 0.000927927919784888 NA NA NA hsa-miR-708-3p LIFR 0.83540388887946 3.55308012540402e-06 -0.846118355938462 2.2628560201304e-11 mirMAP -0.149628054414843 0.000133682916968051 NA NA NA hsa-miR-940 LIFR -0.160421460715008 0.279016637176929 -0.846118355938462 2.2628560201304e-11 MirTarget -0.171835877673586 0.000716099010917788 NA NA NA hsa-miR-96-5p LIFR -1.00223771166604 3.91564621567028e-06 -0.846118355938462 2.2628560201304e-11 mirMAP -0.106079197088172 0.00161690275425357 NA NA NA hsa-miR-28-5p MPL 0.461962042257226 3.32424690573327e-11 -0.562046169615892 6.09272746855396e-08 miRNAWalker2_validate;miRTarBase;miRanda -0.307687769258745 0.000178733240201328 NA NA NA hsa-miR-339-5p MPL 0.322848334531193 0.0117281778821612 -0.562046169615892 6.09272746855396e-08 miRanda -0.145601421137447 0.00135770159148937 NA NA NA hsa-miR-342-5p MPL 1.37011183051517 4.99462376051624e-28 -0.562046169615892 6.09272746855396e-08 MirTarget -0.197087135994485 3.50370068862547e-06 NA NA NA hsa-miR-625-5p MPL 0.153090549230629 0.330314026509869 -0.562046169615892 6.09272746855396e-08 MirTarget -0.137083576832961 0.000640907411885408 NA NA NA hsa-let-7g-5p MYC -0.739744008507763 1.07979566264383e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate;miRTarBase -0.398905767136213 2.71236287032834e-05 NA NA NA hsa-miR-135a-5p MYC -2.13422485001223 6.29449029671498e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.108827259333515 0.000903589484065675 23176581 Moreover based on the results of this analysis we investigated whether miR-135a targeted the c-MYC gene in RCC; Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells kidney renal cell cancer hsa-miR-335-5p MYC -2.09515619961552 1.03765771499548e-25 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.216426299788151 7.62566723121896e-07 NA NA NA hsa-miR-429 MYC -2.16569233119434 2.66862243626443e-37 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.389721783902253 2.72292816859272e-16 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.348985243196771 0.000187889982228835 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.377458526504721 0.000190443255959769 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-let-7e-5p OSMR -0.727009689927955 1.30690859412163e-11 1.36153455502477 3.985324426016e-22 miRNATAP -0.218701520979375 0.00363856962689776 NA NA NA hsa-let-7g-5p OSMR -0.739744008507763 1.07979566264383e-14 1.36153455502477 3.985324426016e-22 miRNATAP -0.268762490903486 0.00130291065633708 NA NA NA hsa-miR-125a-3p OSMR -0.372794471295036 0.000941729459601642 1.36153455502477 3.985324426016e-22 miRanda -0.272689553909526 0.000202745976836239 NA NA NA hsa-miR-139-5p OSMR -0.704802495091118 2.36904108453776e-06 1.36153455502477 3.985324426016e-22 miRanda -0.217612708084317 6.59776085677201e-05 NA NA NA hsa-miR-200b-3p OSMR -1.70383252137161 2.38979336321755e-30 1.36153455502477 3.985324426016e-22 TargetScan -0.326651139657421 3.98337753633749e-11 NA NA NA hsa-miR-335-5p OSMR -2.09515619961552 1.03765771499548e-25 1.36153455502477 3.985324426016e-22 miRNAWalker2_validate -0.127516808514079 0.000976141992860586 NA NA NA hsa-miR-362-3p OSMR -0.753214251798232 3.0025661608035e-07 1.36153455502477 3.985324426016e-22 miRanda -0.463582580033441 2.18081975759679e-17 NA NA NA hsa-miR-374b-5p OSMR 0.0804104684417872 0.365593963035077 1.36153455502477 3.985324426016e-22 mirMAP -0.28315007512758 0.00271123126499023 NA NA NA hsa-miR-429 OSMR -2.16569233119434 2.66862243626443e-37 1.36153455502477 3.985324426016e-22 miRanda;miRNATAP -0.340620538222573 2.82177945406616e-16 NA NA NA hsa-miR-142-5p PIAS2 1.88417391525707 1.2096808039882e-27 -0.322883099061396 0.00014120735419094 mirMAP -0.120448843482292 1.06775795740638e-06 NA NA NA hsa-miR-15a-5p PIAS2 1.42663930007845 1.36006952074963e-57 -0.322883099061396 0.00014120735419094 MirTarget -0.18482446918483 2.68416781481056e-05 NA NA NA hsa-miR-15b-5p PIAS2 0.773001494057531 1.71784656078957e-16 -0.322883099061396 0.00014120735419094 MirTarget -0.227245128534025 1.81486731682233e-06 NA NA NA hsa-miR-16-5p PIAS2 0.934012514027655 4.85417898318515e-24 -0.322883099061396 0.00014120735419094 MirTarget -0.139533242000531 0.00342101892027587 NA NA NA hsa-miR-181a-5p PIAS2 1.11111114875339 3.97880443756442e-29 -0.322883099061396 0.00014120735419094 mirMAP -0.211635164727984 8.91693669008689e-07 NA NA NA hsa-miR-181b-5p PIAS2 1.49054296272357 3.69051660739368e-41 -0.322883099061396 0.00014120735419094 mirMAP -0.218078150549372 2.67778481132797e-09 NA NA NA hsa-miR-193a-3p PIAS2 0.849206638484406 3.68101781083335e-14 -0.322883099061396 0.00014120735419094 MirTarget -0.240032295290293 1.43945898670009e-09 NA NA NA hsa-miR-25-3p PIAS2 1.12016166564779 3.79069348635778e-48 -0.322883099061396 0.00014120735419094 mirMAP -0.220595753511441 2.95302319747502e-05 NA NA NA hsa-miR-26b-5p PIAS2 -0.251437253429904 0.00270935785098697 -0.322883099061396 0.00014120735419094 miRNAWalker2_validate -0.250017088847996 8.01149401985305e-06 NA NA NA hsa-miR-32-5p PIAS2 0.407826130035097 7.26884631998646e-06 -0.322883099061396 0.00014120735419094 mirMAP -0.161788038401888 0.00167494381406037 NA NA NA hsa-miR-576-5p PIAS2 1.06681109513983 5.69294424466526e-24 -0.322883099061396 0.00014120735419094 mirMAP -0.109764569868922 0.00837659397680175 NA NA NA hsa-miR-590-3p PIAS2 1.13702599385212 3.53435739887793e-22 -0.322883099061396 0.00014120735419094 miRanda;mirMAP;miRNATAP -0.154452043751079 3.64566786189632e-05 NA NA NA hsa-miR-328-3p PIAS3 0.011417538344733 0.906769951090636 0.23875287279192 3.3209893745765e-06 MirTarget -0.119697939217914 4.45285788926986e-05 NA NA NA hsa-miR-532-3p PIAS3 -1.759223962964 7.9077916669414e-40 0.23875287279192 3.3209893745765e-06 miRNATAP -0.125772673394308 7.35506759197592e-12 NA NA NA hsa-let-7f-1-3p PIK3CA 0.477913872379336 4.46669616865068e-05 -0.342309377518198 0.000115361959187206 mirMAP -0.117169302105272 0.00980511224865979 NA NA NA hsa-miR-148a-5p PIK3CA 0.415500302855613 0.000691460831436767 -0.342309377518198 0.000115361959187206 mirMAP -0.127137756769153 0.00150846590255829 NA NA NA hsa-miR-320b PIK3CA 0.300497419754843 0.0245219177384172 -0.342309377518198 0.000115361959187206 miRanda -0.109684919459557 0.00295331979925903 NA NA NA hsa-miR-339-5p PIK3CA 0.322848334531193 0.0117281778821612 -0.342309377518198 0.000115361959187206 miRanda -0.156390103299638 4.31357238138231e-05 NA NA NA hsa-miR-590-3p PIK3CA 1.13702599385212 3.53435739887793e-22 -0.342309377518198 0.000115361959187206 miRanda;mirMAP -0.167970910292111 1.76355187639927e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.709763558412506 1.11883921359361e-11 -0.342309377518198 0.000115361959187206 miRanda -0.179027916238388 8.77558290901021e-05 NA NA NA hsa-miR-130b-3p PIK3CB 1.12788913578446 2.939369462276e-16 -0.247995112719303 0.00148503458375338 miRNATAP -0.166034631736904 1.58184303321712e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.722913586880779 2.76301458932381e-10 -0.247995112719303 0.00148503458375338 miRNATAP -0.138948641019506 0.000146950619817948 NA NA NA hsa-miR-19b-3p PIK3CB 0.195940928879427 0.0300512922542325 -0.247995112719303 0.00148503458375338 miRNATAP -0.155249167038679 0.00123255333914152 NA NA NA hsa-miR-25-3p PIK3CB 1.12016166564779 3.79069348635778e-48 -0.247995112719303 0.00148503458375338 miRNATAP -0.168848015389201 0.000511445370430535 NA NA NA hsa-miR-590-3p PIK3CB 1.13702599385212 3.53435739887793e-22 -0.247995112719303 0.00148503458375338 miRNATAP -0.152204162601648 8.6055969781532e-06 NA NA NA hsa-miR-92b-3p PIK3CB 0.418630595140165 6.50466149211154e-05 -0.247995112719303 0.00148503458375338 miRNATAP -0.132204554754912 0.00123182058684873 NA NA NA hsa-miR-10b-5p PIK3CD -0.89971464210447 1.18190532299934e-20 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate -0.322882758324939 5.32986923354336e-10 NA NA NA hsa-miR-1468-5p PIK3CD -0.311126383179539 0.00979113361106863 0.827862115800704 6.93199253004924e-19 MirTarget -0.200155097962759 8.08016260976088e-06 NA NA NA hsa-miR-30a-5p PIK3CD -0.778411951775343 2.73322451127932e-16 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.206007694378125 0.000161176631172019 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -1.64703050862226 1.89878531036464e-31 0.827862115800704 6.93199253004924e-19 MirTarget -0.256459682857462 3.84122966933957e-14 NA NA NA hsa-miR-30b-5p PIK3CD -1.18330589477119 6.8341618466966e-27 0.827862115800704 6.93199253004924e-19 MirTarget -0.212463225121162 2.43792629370427e-06 NA NA NA hsa-miR-30c-5p PIK3CD -1.08783070774238 2.02505402525786e-24 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.191697315876392 4.85249073283528e-05 NA NA NA hsa-miR-30d-5p PIK3CD -0.202727675788184 0.00659067084745794 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.209303428523125 0.00450077920142443 NA NA NA hsa-miR-106b-5p PIK3R1 1.07509411417907 2.11739194181878e-36 -0.234314125271815 0.0111750886765385 MirTarget;miRNATAP -0.179369079303185 0.000816789511004284 NA NA NA hsa-miR-221-3p PIK3R1 0.337895669520713 0.0136448974691037 -0.234314125271815 0.0111750886765385 MirTarget -0.163462882563838 9.21701112965761e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.214811008033524 0.0965295551752457 -0.234314125271815 0.0111750886765385 MirTarget -0.107248741245045 0.00671314109485487 NA NA NA hsa-miR-590-3p PIK3R1 1.13702599385212 3.53435739887793e-22 -0.234314125271815 0.0111750886765385 miRanda;mirMAP -0.106905404095112 0.00880343764678398 NA NA NA hsa-miR-182-5p PIK3R3 -0.608710746044567 0.0025264935278104 0.439819702071113 8.25824839758606e-05 mirMAP -0.153374534942348 3.96734579923425e-07 NA NA NA hsa-miR-339-5p PIK3R3 0.322848334531193 0.0117281778821612 0.439819702071113 8.25824839758606e-05 MirTarget;miRanda -0.192609585710903 6.48743953207512e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.80809616164259 2.36039522526e-12 0.439819702071113 8.25824839758606e-05 MirTarget -0.16533292375838 0.00153486106521956 NA NA NA hsa-miR-96-5p PIK3R3 -1.00223771166604 3.91564621567028e-06 0.439819702071113 8.25824839758606e-05 mirMAP -0.164731670984697 7.78245878052581e-09 NA NA NA hsa-miR-125a-3p PIK3R5 -0.372794471295036 0.000941729459601642 3.18542758418586 6.04695754116875e-70 miRanda -0.407465916624748 0.000192324867439568 NA NA NA hsa-miR-125a-5p PIK3R5 -0.561874059994802 7.3931856356891e-13 3.18542758418586 6.04695754116875e-70 MirTarget;miRanda -1.34358622921882 2.31129700790236e-20 NA NA NA hsa-miR-125b-5p PIK3R5 -0.825456421494266 2.13029877878434e-15 3.18542758418586 6.04695754116875e-70 MirTarget -0.67295054872876 1.75325492827967e-09 NA NA NA hsa-miR-615-3p PIK3R5 -0.777370544471479 2.08193713560545e-08 3.18542758418586 6.04695754116875e-70 miRanda -0.258205105771951 0.00312779262258178 NA NA NA hsa-let-7b-5p PRLR 0.770868211539597 6.63408323707647e-21 -2.33157610117756 4.45365623526936e-19 miRNATAP -1.0005583123768 6.8819914657881e-09 NA NA NA hsa-let-7i-5p PRLR 0.911372377723717 7.11483853341932e-31 -2.33157610117756 4.45365623526936e-19 miRNATAP -1.30467344994099 2.32535623464079e-14 NA NA NA hsa-miR-130b-3p PRLR 1.12788913578446 2.939369462276e-16 -2.33157610117756 4.45365623526936e-19 mirMAP -0.509352084667327 1.11771517839996e-06 NA NA NA hsa-miR-146b-5p PRLR 1.40714170253819 2.9559871816487e-12 -2.33157610117756 4.45365623526936e-19 mirMAP -0.21171601343598 0.0037686277409964 NA NA NA hsa-miR-15b-3p PRLR 1.49422666971434 5.44139893275088e-29 -2.33157610117756 4.45365623526936e-19 mirMAP -0.384665188853191 0.000224416743379344 NA NA NA hsa-miR-16-1-3p PRLR 1.51429140700091 3.17219833254498e-37 -2.33157610117756 4.45365623526936e-19 mirMAP -0.481601739803053 3.11352685541326e-05 NA NA NA hsa-miR-181a-5p PRLR 1.11111114875339 3.97880443756442e-29 -2.33157610117756 4.45365623526936e-19 miRNAWalker2_validate;miRNATAP -0.826948573257886 2.31582068102425e-09 NA NA NA hsa-miR-181b-5p PRLR 1.49054296272357 3.69051660739368e-41 -2.33157610117756 4.45365623526936e-19 miRNATAP -0.788166705426133 2.41604924801189e-11 NA NA NA hsa-miR-181c-5p PRLR 0.762784646696248 4.48373118147729e-10 -2.33157610117756 4.45365623526936e-19 miRNATAP -0.974996882335858 4.96003851392019e-17 NA NA NA hsa-miR-186-5p PRLR 0.507217561043443 9.04455748270995e-10 -2.33157610117756 4.45365623526936e-19 mirMAP -0.527858024162186 0.00363227063785654 NA NA NA hsa-miR-196a-5p PRLR 0.440858887700369 2.0077143292463e-05 -2.33157610117756 4.45365623526936e-19 miRNATAP -0.476692298670046 0.00114256997158285 NA NA NA hsa-miR-19b-1-5p PRLR 0.66692013055553 1.55789130176287e-09 -2.33157610117756 4.45365623526936e-19 mirMAP -0.658896610022628 8.7537866772563e-07 NA NA NA hsa-miR-20a-3p PRLR -0.112128426252791 0.346272219285942 -2.33157610117756 4.45365623526936e-19 mirMAP -0.366545379247601 0.00446864488559455 NA NA NA hsa-miR-320a PRLR 0.412740558379182 2.02929519701706e-05 -2.33157610117756 4.45365623526936e-19 miRanda -0.942024787290485 8.27669367314301e-10 NA NA NA hsa-miR-320b PRLR 0.300497419754843 0.0245219177384172 -2.33157610117756 4.45365623526936e-19 miRanda -0.565616571531024 5.38648880476492e-07 NA NA NA hsa-miR-340-5p PRLR 1.14479851941741 2.91936881701444e-15 -2.33157610117756 4.45365623526936e-19 mirMAP -0.345027649962491 0.000598693374588384 NA NA NA hsa-miR-374a-3p PRLR 1.13863935833993 2.79089304015401e-44 -2.33157610117756 4.45365623526936e-19 mirMAP -0.635263456622248 0.00010074348398504 NA NA NA hsa-miR-454-3p PRLR 0.68285296887698 1.17407812677787e-08 -2.33157610117756 4.45365623526936e-19 mirMAP -0.449308028087524 0.000312865069244154 NA NA NA hsa-miR-455-5p PRLR 0.773674551205946 2.12957541541474e-09 -2.33157610117756 4.45365623526936e-19 miRanda -0.338445642310627 0.00338559723838809 NA NA NA hsa-miR-576-5p PRLR 1.06681109513983 5.69294424466526e-24 -2.33157610117756 4.45365623526936e-19 mirMAP -0.763771962747565 7.78783160172633e-09 NA NA NA hsa-miR-7-1-3p PRLR 0.544601828025304 5.33830451326047e-07 -2.33157610117756 4.45365623526936e-19 mirMAP -0.45833044684731 0.000942752381945947 NA NA NA hsa-let-7a-3p PTPN11 0.0677487960013088 0.460458477653989 -0.341712742609257 1.33147607483599e-07 mirMAP -0.165904915410155 2.81371142679823e-05 NA NA NA hsa-miR-181a-5p PTPN11 1.11111114875339 3.97880443756442e-29 -0.341712742609257 1.33147607483599e-07 miRNAWalker2_validate;miRTarBase -0.141525373268749 2.14767082806646e-05 NA NA NA hsa-miR-19b-3p PTPN11 0.195940928879427 0.0300512922542325 -0.341712742609257 1.33147607483599e-07 mirMAP -0.132361233509163 0.00103786554162883 NA NA NA hsa-miR-28-5p PTPN11 0.461962042257226 3.32424690573327e-11 -0.341712742609257 1.33147607483599e-07 miRanda -0.201474606930361 7.74069832521273e-05 NA NA NA hsa-miR-320a PTPN11 0.412740558379182 2.02929519701706e-05 -0.341712742609257 1.33147607483599e-07 miRNAWalker2_validate;mirMAP -0.116787905747509 0.00169734274185247 NA NA NA hsa-miR-374b-5p PTPN11 0.0804104684417872 0.365593963035077 -0.341712742609257 1.33147607483599e-07 mirMAP -0.121011924905068 0.00332584176997666 NA NA NA hsa-miR-455-5p PTPN11 0.773674551205946 2.12957541541474e-09 -0.341712742609257 1.33147607483599e-07 miRanda -0.153745537425232 1.12242619416936e-08 NA NA NA hsa-miR-130b-5p SOCS2 0.92990617673277 3.75880436852717e-12 -0.968412268816397 8.72060942979144e-15 miRNATAP -0.317711142054137 3.83977333968857e-10 NA NA NA hsa-miR-16-1-3p SOCS2 1.51429140700091 3.17219833254498e-37 -0.968412268816397 8.72060942979144e-15 mirMAP -0.292650420664507 5.68914447285792e-08 NA NA NA hsa-miR-16-5p SOCS2 0.934012514027655 4.85417898318515e-24 -0.968412268816397 8.72060942979144e-15 miRNAWalker2_validate -0.39898064091208 2.39430868828538e-08 NA NA NA hsa-miR-186-5p SOCS2 0.507217561043443 9.04455748270995e-10 -0.968412268816397 8.72060942979144e-15 mirMAP -0.42277142241047 5.33572917801891e-07 NA NA NA hsa-miR-19a-3p SOCS2 0.722913586880779 2.76301458932381e-10 -0.968412268816397 8.72060942979144e-15 mirMAP -0.195845643597549 0.00135992452214476 NA NA NA hsa-miR-25-3p SOCS2 1.12016166564779 3.79069348635778e-48 -0.968412268816397 8.72060942979144e-15 mirMAP -0.502136986764156 2.29609778739295e-10 NA NA NA hsa-miR-342-3p SOCS2 1.4124432570595 1.07208971556131e-28 -0.968412268816397 8.72060942979144e-15 miRanda -0.324730912348916 1.30444186552036e-10 NA NA NA hsa-miR-576-5p SOCS2 1.06681109513983 5.69294424466526e-24 -0.968412268816397 8.72060942979144e-15 PITA -0.343284049945277 3.77496916967319e-08 NA NA NA hsa-miR-590-3p SOCS2 1.13702599385212 3.53435739887793e-22 -0.968412268816397 8.72060942979144e-15 mirMAP -0.418032342526846 4.39490557654551e-14 NA NA NA hsa-miR-7-1-3p SOCS2 0.544601828025304 5.33830451326047e-07 -0.968412268816397 8.72060942979144e-15 mirMAP -0.242080546780718 0.000199090758977867 NA NA NA hsa-miR-455-3p SOCS3 0.171798655137046 0.261841668213493 0.363623085112962 0.0422551664829299 mirMAP -0.181597770064297 0.00500302895787221 NA NA NA hsa-let-7b-5p SOCS4 0.770868211539597 6.63408323707647e-21 -0.653724248807649 5.49514621472628e-19 miRNATAP -0.150978028122401 0.00218011047843256 NA NA NA hsa-let-7i-5p SOCS4 0.911372377723717 7.11483853341932e-31 -0.653724248807649 5.49514621472628e-19 miRNATAP -0.275228476891694 1.75544919569249e-08 NA NA NA hsa-miR-130b-3p SOCS4 1.12788913578446 2.939369462276e-16 -0.653724248807649 5.49514621472628e-19 miRNAWalker2_validate -0.181069639223724 3.99516958144503e-10 NA NA NA hsa-miR-140-3p SOCS4 0.989350547007025 6.14964028267239e-25 -0.653724248807649 5.49514621472628e-19 PITA;miRNATAP -0.123270367761761 0.00298346547450375 NA NA NA hsa-miR-142-5p SOCS4 1.88417391525707 1.2096808039882e-27 -0.653724248807649 5.49514621472628e-19 mirMAP -0.146746700915843 2.98009409895019e-11 NA NA NA hsa-miR-16-2-3p SOCS4 1.3046118743965 4.17207934608428e-19 -0.653724248807649 5.49514621472628e-19 mirMAP -0.1290226427907 2.43342137260788e-06 NA NA NA hsa-miR-186-5p SOCS4 0.507217561043443 9.04455748270995e-10 -0.653724248807649 5.49514621472628e-19 mirMAP -0.268008310425442 8.54821739426093e-08 NA NA NA hsa-miR-196a-5p SOCS4 0.440858887700369 2.0077143292463e-05 -0.653724248807649 5.49514621472628e-19 miRNATAP -0.210455026184791 2.07338778709565e-07 NA NA NA hsa-miR-19b-3p SOCS4 0.195940928879427 0.0300512922542325 -0.653724248807649 5.49514621472628e-19 miRNAWalker2_validate -0.123434301593174 0.00974006501402036 NA NA NA hsa-miR-21-5p SOCS4 2.51462371613332 3.30620591950316e-66 -0.653724248807649 5.49514621472628e-19 miRNAWalker2_validate -0.227087189976511 9.4222165350946e-25 NA NA NA hsa-miR-27a-3p SOCS4 0.558934437526245 1.44256383086177e-12 -0.653724248807649 5.49514621472628e-19 miRNATAP -0.384441158881092 4.56771420405851e-14 NA NA NA hsa-miR-320a SOCS4 0.412740558379182 2.02929519701706e-05 -0.653724248807649 5.49514621472628e-19 miRNATAP -0.156488400643736 0.00035269402641144 NA NA NA hsa-miR-320b SOCS4 0.300497419754843 0.0245219177384172 -0.653724248807649 5.49514621472628e-19 miRNATAP -0.117143763887573 0.000239072723503491 NA NA NA hsa-miR-34a-5p SOCS4 1.07544567720768 1.81510842038009e-20 -0.653724248807649 5.49514621472628e-19 miRNAWalker2_validate;miRNATAP -0.235847324556078 2.60929925815967e-12 NA NA NA hsa-miR-374a-5p SOCS4 0.543061152108237 2.19403097299769e-14 -0.653724248807649 5.49514621472628e-19 mirMAP -0.190710368975059 0.00110377479050299 NA NA NA hsa-miR-455-5p SOCS4 0.773674551205946 2.12957541541474e-09 -0.653724248807649 5.49514621472628e-19 miRanda -0.159827123897732 5.61555238500533e-07 NA NA NA hsa-miR-576-5p SOCS4 1.06681109513983 5.69294424466526e-24 -0.653724248807649 5.49514621472628e-19 PITA;mirMAP -0.197730916729058 1.06002600770802e-07 NA NA NA hsa-miR-590-3p SOCS4 1.13702599385212 3.53435739887793e-22 -0.653724248807649 5.49514621472628e-19 PITA;miRanda;mirMAP;miRNATAP -0.166850269523271 7.83829107878993e-07 NA NA NA hsa-miR-616-5p SOCS4 0.913426384742148 3.78418389333709e-09 -0.653724248807649 5.49514621472628e-19 mirMAP -0.107995119455484 7.36157422488167e-05 NA NA NA hsa-miR-107 SOCS5 0.140046250553248 0.0943611632552367 -0.129039340944518 0.0384634286028189 miRanda -0.198903554075496 1.12785044942644e-06 NA NA NA hsa-miR-374b-5p SOCS5 0.0804104684417872 0.365593963035077 -0.129039340944518 0.0384634286028189 mirMAP -0.139869907675792 0.000312611518790587 NA NA NA hsa-miR-590-5p SOCS5 0.709763558412506 1.11883921359361e-11 -0.129039340944518 0.0384634286028189 miRanda -0.109559802289597 0.000566824894724194 NA NA NA hsa-miR-17-5p SOCS7 0.494260110870015 3.8348005261e-09 -0.693757903509327 5.72635947855136e-07 TargetScan -0.284547688383528 0.00183523916035747 NA NA NA hsa-miR-2355-5p SOCS7 1.57515081110162 3.54962327490702e-48 -0.693757903509327 5.72635947855136e-07 miRNATAP -0.193643716428978 0.00179884392623315 NA NA NA hsa-miR-320a SOCS7 0.412740558379182 2.02929519701706e-05 -0.693757903509327 5.72635947855136e-07 PITA;miRanda -0.23271571038964 0.00359611225614944 NA NA NA hsa-miR-320b SOCS7 0.300497419754843 0.0245219177384172 -0.693757903509327 5.72635947855136e-07 PITA;miRanda -0.194300942305542 0.000826167599398201 NA NA NA hsa-miR-590-5p SOCS7 0.709763558412506 1.11883921359361e-11 -0.693757903509327 5.72635947855136e-07 miRanda -0.292420839594385 4.81475020593667e-05 NA NA NA hsa-miR-96-5p SOCS7 -1.00223771166604 3.91564621567028e-06 -0.693757903509327 5.72635947855136e-07 TargetScan -0.106819520610848 0.00333792337810532 NA NA NA hsa-miR-22-5p SOS1 -0.197038086012602 0.106234828461117 0.165657937822672 0.00695508624793917 miRNATAP -0.1259671249937 4.71993758199897e-06 NA NA NA hsa-miR-27b-3p SOS1 -0.699527231242518 1.07356023759234e-15 0.165657937822672 0.00695508624793917 MirTarget;miRNATAP -0.147080230611449 7.31565228121447e-05 NA NA NA hsa-miR-30b-5p SOS1 -1.18330589477119 6.8341618466966e-27 0.165657937822672 0.00695508624793917 mirMAP -0.138149072736721 7.79904823834726e-07 NA NA NA hsa-miR-361-5p SOS1 0.0514169367202078 0.382929376393199 0.165657937822672 0.00695508624793917 miRanda -0.17245343753156 0.00341644954529283 NA NA NA hsa-miR-130b-3p SOS2 1.12788913578446 2.939369462276e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.219389641555847 2.49951089457902e-14 NA NA NA hsa-miR-146b-5p SOS2 1.40714170253819 2.9559871816487e-12 -0.603803978860436 7.13914474388309e-16 miRanda -0.147776164302161 1.19506749629666e-13 NA NA NA hsa-miR-15a-5p SOS2 1.42663930007845 1.36006952074963e-57 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.253370307078702 1.58238296990946e-10 NA NA NA hsa-miR-15b-5p SOS2 0.773001494057531 1.71784656078957e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.335211578081185 2.30658617778889e-15 NA NA NA hsa-miR-16-5p SOS2 0.934012514027655 4.85417898318515e-24 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.24200816200432 1.67224378158762e-08 NA NA NA hsa-miR-193a-3p SOS2 0.849206638484406 3.68101781083335e-14 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.269886140589803 4.58383896803507e-14 NA NA NA hsa-miR-21-5p SOS2 2.51462371613332 3.30620591950316e-66 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.237021856922544 1.01167070366515e-26 NA NA NA hsa-miR-301a-3p SOS2 0.259400847075798 0.0216890736701418 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.116740679991895 0.00226202627325341 NA NA NA hsa-miR-320a SOS2 0.412740558379182 2.02929519701706e-05 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.205432651949533 2.81576440891282e-06 NA NA NA hsa-miR-320b SOS2 0.300497419754843 0.0245219177384172 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.152878780959194 1.68250949578106e-06 NA NA NA hsa-miR-454-3p SOS2 0.68285296887698 1.17407812677787e-08 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.1714669429965 9.02571972797797e-07 NA NA NA hsa-miR-590-3p SOS2 1.13702599385212 3.53435739887793e-22 -0.603803978860436 7.13914474388309e-16 miRanda;mirMAP -0.229417057761137 7.37633999411141e-12 NA NA NA hsa-miR-590-5p SOS2 0.709763558412506 1.11883921359361e-11 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.223093386542166 1.51960822756839e-08 NA NA NA hsa-miR-183-5p SPRED1 -1.21596931064487 1.31473205758898e-08 0.572476105347971 4.04715796353071e-12 miRNATAP -0.121874055026592 7.00272207631561e-09 NA NA NA hsa-miR-188-5p SPRED1 -1.74586655806628 1.50431624674552e-28 0.572476105347971 4.04715796353071e-12 PITA;miRNATAP -0.183366482085668 2.2344799174442e-11 NA NA NA hsa-miR-200a-3p SPRED1 -1.43409013664263 2.00188483717828e-20 0.572476105347971 4.04715796353071e-12 miRNATAP -0.170793121212845 9.44214938818306e-10 NA NA NA hsa-miR-200b-3p SPRED1 -1.70383252137161 2.38979336321755e-30 0.572476105347971 4.04715796353071e-12 TargetScan -0.211492879324949 2.11796702224635e-14 NA NA NA hsa-miR-20b-5p SPRED1 -1.30218163823367 6.87172815978149e-17 0.572476105347971 4.04715796353071e-12 miRNATAP -0.118809106559814 3.11000684253583e-05 NA NA NA hsa-miR-361-5p SPRED1 0.0514169367202078 0.382929376393199 0.572476105347971 4.04715796353071e-12 miRanda -0.212765759888248 0.00951874674502948 NA NA NA hsa-miR-363-3p SPRED1 -1.93551166555337 4.45368477487614e-32 0.572476105347971 4.04715796353071e-12 mirMAP -0.115391551372669 7.12641609162524e-06 NA NA NA hsa-miR-429 SPRED1 -2.16569233119434 2.66862243626443e-37 0.572476105347971 4.04715796353071e-12 miRNATAP -0.169521176412106 1.17211925503908e-12 NA NA NA hsa-miR-500a-5p SPRED1 -1.28374735824553 1.95870374809798e-20 0.572476105347971 4.04715796353071e-12 mirMAP -0.156804725361134 6.85446489214439e-07 NA NA NA hsa-miR-339-5p SPRED2 0.322848334531193 0.0117281778821612 0.120362632927433 0.145241317689412 miRanda -0.145441668658888 3.63496795007279e-05 NA NA NA hsa-miR-532-5p SPRED2 -1.09700348358668 8.34836230254408e-26 0.120362632927433 0.145241317689412 PITA -0.127449100054364 0.00156130144509069 NA NA NA hsa-miR-29a-3p SPRY1 -0.431613225927952 4.10166815070288e-08 1.25498955926738 1.60787916804659e-18 miRNATAP -0.740909277852411 2.83824766124269e-13 NA NA NA hsa-miR-29b-3p SPRY1 -0.228125979913806 0.0271621721891603 1.25498955926738 1.60787916804659e-18 miRNATAP -0.506656373899956 1.44209469354263e-10 NA NA NA hsa-miR-29c-3p SPRY1 -0.238671318446745 0.0141475322347596 1.25498955926738 1.60787916804659e-18 miRNATAP -0.337199726723487 8.11508613515792e-05 NA NA NA hsa-miR-324-3p SPRY1 -0.197662887871899 0.0298845059559819 1.25498955926738 1.60787916804659e-18 miRNAWalker2_validate -0.373392019983397 4.73984420976275e-05 NA NA NA hsa-miR-148a-3p SPRY2 0.343233211643815 0.00402279073598165 -0.362212615547156 0.000207062361120635 miRNAWalker2_validate -0.228283664522478 3.43485311833474e-07 NA NA NA hsa-miR-21-5p SPRY2 2.51462371613332 3.30620591950316e-66 -0.362212615547156 0.000207062361120635 miRNAWalker2_validate;miRTarBase;miRNATAP -0.162526039806668 4.18920061185902e-08 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-590-3p SPRY2 1.13702599385212 3.53435739887793e-22 -0.362212615547156 0.000207062361120635 PITA;miRanda;mirMAP;miRNATAP -0.230160838628476 6.85470776161516e-08 NA NA NA hsa-miR-590-5p SPRY2 0.709763558412506 1.11883921359361e-11 -0.362212615547156 0.000207062361120635 PITA;miRanda;miRNATAP -0.23827561981244 1.78941769268633e-06 NA NA NA hsa-miR-130b-3p SPRY3 1.12788913578446 2.939369462276e-16 -0.157364551448405 0.0684282051399124 mirMAP -0.133441643187453 4.57983215855632e-05 NA NA NA hsa-miR-130b-5p SPRY3 0.92990617673277 3.75880436852717e-12 -0.157364551448405 0.0684282051399124 mirMAP -0.106898660261844 0.00184999286188284 NA NA NA hsa-miR-148b-3p SPRY3 0.346011252093377 4.27203463315056e-06 -0.157364551448405 0.0684282051399124 mirMAP -0.206624442523966 0.00104540300236943 NA NA NA hsa-miR-186-5p SPRY3 0.507217561043443 9.04455748270995e-10 -0.157364551448405 0.0684282051399124 mirMAP -0.191581774151699 0.000676159107605361 NA NA NA hsa-miR-26b-3p SPRY3 -0.103733827937392 0.295475837589548 -0.157364551448405 0.0684282051399124 mirMAP -0.127698492135618 0.00829340364343309 NA NA NA hsa-miR-28-5p SPRY3 0.461962042257226 3.32424690573327e-11 -0.157364551448405 0.0684282051399124 MirTarget;miRNATAP -0.269552419416561 5.46627971734056e-05 NA NA NA hsa-miR-339-5p SPRY3 0.322848334531193 0.0117281778821612 -0.157364551448405 0.0684282051399124 miRanda -0.183707692488261 5.2756368696675e-07 NA NA NA hsa-miR-106a-5p SPRY4 -0.830908656792615 2.67547872901508e-10 1.1598101501684 1.26428993127742e-19 miRNATAP -0.317660054005405 5.13563358832234e-09 NA NA NA hsa-miR-141-3p SPRY4 -5.87110686537457 1.20877726722907e-85 1.1598101501684 1.26428993127742e-19 TargetScan;miRNATAP -0.186153703782743 1.96186413139331e-25 NA NA NA hsa-miR-148a-5p SPRY4 0.415500302855613 0.000691460831436767 1.1598101501684 1.26428993127742e-19 mirMAP -0.180444644993967 0.0030448978218189 NA NA NA hsa-miR-182-5p SPRY4 -0.608710746044567 0.0025264935278104 1.1598101501684 1.26428993127742e-19 miRNATAP -0.227467124866018 2.79753039719676e-10 NA NA NA hsa-miR-200a-3p SPRY4 -1.43409013664263 2.00188483717828e-20 1.1598101501684 1.26428993127742e-19 mirMAP;miRNATAP -0.289229180578788 6.56970176035783e-11 NA NA NA hsa-miR-20b-5p SPRY4 -1.30218163823367 6.87172815978149e-17 1.1598101501684 1.26428993127742e-19 miRNATAP -0.267484516911259 2.3800796388332e-09 NA NA NA hsa-miR-29a-3p SPRY4 -0.431613225927952 4.10166815070288e-08 1.1598101501684 1.26428993127742e-19 miRNATAP -0.666916269327632 2.55910517737483e-13 NA NA NA hsa-miR-29b-3p SPRY4 -0.228125979913806 0.0271621721891603 1.1598101501684 1.26428993127742e-19 miRNATAP -0.468899381828283 3.66959469045419e-11 NA NA NA hsa-miR-29c-3p SPRY4 -0.238671318446745 0.0141475322347596 1.1598101501684 1.26428993127742e-19 miRNATAP -0.367694849209189 1.50578571036304e-06 NA NA NA hsa-miR-30b-3p SPRY4 -1.64703050862226 1.89878531036464e-31 1.1598101501684 1.26428993127742e-19 miRNATAP -0.375895648684569 5.26091957902608e-16 NA NA NA hsa-miR-335-5p SPRY4 -2.09515619961552 1.03765771499548e-25 1.1598101501684 1.26428993127742e-19 miRNAWalker2_validate -0.21277113814395 4.46623693250033e-10 NA NA NA hsa-miR-429 SPRY4 -2.16569233119434 2.66862243626443e-37 1.1598101501684 1.26428993127742e-19 miRanda -0.320990707824607 8.03558599785642e-18 NA NA NA hsa-miR-509-3p SPRY4 -2.24650406059054 1.08256825220159e-24 1.1598101501684 1.26428993127742e-19 mirMAP -0.220096886688945 6.46245203813103e-13 NA NA NA hsa-miR-24-3p STAM 0.173813044685099 0.00565259443420961 -0.451798883858584 7.23605341045909e-16 MirTarget -0.213827884070177 3.70132826790243e-05 NA NA NA hsa-miR-25-3p STAM 1.12016166564779 3.79069348635778e-48 -0.451798883858584 7.23605341045909e-16 MirTarget -0.213730879596252 1.89544671255661e-09 NA NA NA hsa-miR-32-5p STAM 0.407826130035097 7.26884631998646e-06 -0.451798883858584 7.23605341045909e-16 MirTarget -0.10737322317137 0.0022855864140616 NA NA NA hsa-miR-590-3p STAM 1.13702599385212 3.53435739887793e-22 -0.451798883858584 7.23605341045909e-16 MirTarget;miRanda -0.101791988004341 6.95179698661015e-05 NA NA NA hsa-miR-92b-3p STAM 0.418630595140165 6.50466149211154e-05 -0.451798883858584 7.23605341045909e-16 MirTarget -0.105276399286153 0.000551872780396563 NA NA NA hsa-miR-101-3p STAM2 0.683973909682285 2.88573524246948e-15 -0.719706735250841 1.17388263722267e-32 miRNATAP -0.16317555553943 6.18592730530313e-05 NA NA NA hsa-miR-140-5p STAM2 0.504309496243674 3.09884038729031e-11 -0.719706735250841 1.17388263722267e-32 miRanda -0.192173939433915 4.82169179212398e-05 NA NA NA hsa-miR-142-5p STAM2 1.88417391525707 1.2096808039882e-27 -0.719706735250841 1.17388263722267e-32 mirMAP -0.149264694647388 1.54125391318994e-15 NA NA NA hsa-miR-15b-3p STAM2 1.49422666971434 5.44139893275088e-29 -0.719706735250841 1.17388263722267e-32 mirMAP -0.168431802787227 6.03394671233642e-12 NA NA NA hsa-miR-186-5p STAM2 0.507217561043443 9.04455748270995e-10 -0.719706735250841 1.17388263722267e-32 mirMAP -0.173184738480143 6.81940890282493e-05 NA NA NA hsa-miR-23a-3p STAM2 0.761438723382355 4.09310879199257e-27 -0.719706735250841 1.17388263722267e-32 mirMAP -0.367308808493669 3.38176568096656e-15 NA NA NA hsa-miR-25-3p STAM2 1.12016166564779 3.79069348635778e-48 -0.719706735250841 1.17388263722267e-32 mirMAP -0.321128810367547 7.1670533378209e-16 NA NA NA hsa-miR-32-5p STAM2 0.407826130035097 7.26884631998646e-06 -0.719706735250841 1.17388263722267e-32 mirMAP -0.130339679096261 0.00118851992527599 NA NA NA hsa-miR-320a STAM2 0.412740558379182 2.02929519701706e-05 -0.719706735250841 1.17388263722267e-32 miRanda -0.118620918882943 0.00168492738871601 NA NA NA hsa-miR-330-5p STAM2 1.44960468659754 2.12131210588035e-45 -0.719706735250841 1.17388263722267e-32 miRanda -0.236749293803359 2.92839671487613e-15 NA NA NA hsa-miR-34a-5p STAM2 1.07544567720768 1.81510842038009e-20 -0.719706735250841 1.17388263722267e-32 miRNAWalker2_validate -0.21022634535103 3.59477383492411e-13 NA NA NA hsa-miR-452-5p STAM2 2.05325688842141 2.82238393643084e-40 -0.719706735250841 1.17388263722267e-32 MirTarget -0.165379981263815 1.62098743568083e-16 NA NA NA hsa-miR-455-5p STAM2 0.773674551205946 2.12957541541474e-09 -0.719706735250841 1.17388263722267e-32 miRanda -0.120866860314805 1.19636241816198e-05 NA NA NA hsa-miR-590-3p STAM2 1.13702599385212 3.53435739887793e-22 -0.719706735250841 1.17388263722267e-32 miRanda;mirMAP;miRNATAP -0.166921203156662 7.35731168276463e-09 NA NA NA hsa-miR-92b-3p STAM2 0.418630595140165 6.50466149211154e-05 -0.719706735250841 1.17388263722267e-32 mirMAP -0.205203194712386 1.9982361229661e-09 NA NA NA hsa-miR-10b-3p STAT1 -0.8205021989966 7.84331443044781e-21 0.208240981942267 0.0763522950196464 mirMAP -0.391918199078388 1.12834375620649e-08 NA NA NA hsa-miR-30c-2-3p STAT1 -1.28402709024345 6.77577627955178e-25 0.208240981942267 0.0763522950196464 MirTarget -0.244601480782622 2.71787358233718e-07 NA NA NA hsa-miR-361-5p STAT1 0.0514169367202078 0.382929376393199 0.208240981942267 0.0763522950196464 miRanda -0.316052669533315 0.00514727604527624 NA NA NA hsa-let-7a-5p STAT2 0.0791334022258656 0.422980622613373 0.775363434430604 1.99092141609523e-21 MirTarget -0.126558784160694 0.00979569108377416 NA NA NA hsa-let-7c-5p STAT2 -0.293028324454433 0.00593011890352725 0.775363434430604 1.99092141609523e-21 MirTarget -0.209405891197515 2.66799161694321e-06 NA NA NA hsa-let-7d-5p STAT2 -0.0696879530236796 0.333110939877203 0.775363434430604 1.99092141609523e-21 MirTarget -0.244357481824576 0.000293005383188599 NA NA NA hsa-let-7e-5p STAT2 -0.727009689927955 1.30690859412163e-11 0.775363434430604 1.99092141609523e-21 MirTarget -0.298553758768581 1.20875744364076e-12 NA NA NA hsa-let-7g-5p STAT2 -0.739744008507763 1.07979566264383e-14 0.775363434430604 1.99092141609523e-21 MirTarget -0.187613509413173 9.41463236335554e-05 NA NA NA hsa-miR-125a-3p STAT2 -0.372794471295036 0.000941729459601642 0.775363434430604 1.99092141609523e-21 miRanda -0.162889792086099 0.000118063694297801 NA NA NA hsa-miR-125a-5p STAT2 -0.561874059994802 7.3931856356891e-13 0.775363434430604 1.99092141609523e-21 miRNAWalker2_validate -0.446896088909256 6.52994121478886e-15 NA NA NA hsa-miR-106b-5p STAT3 1.07509411417907 2.11739194181878e-36 -0.33375275309024 4.83262584942865e-11 miRNATAP -0.176529941521813 2.32995207137278e-09 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-93-5p STAT3 1.37365940377595 2.37567548683245e-46 -0.33375275309024 4.83262584942865e-11 miRNAWalker2_validate;miRNATAP -0.10217333112584 7.2245845122828e-05 NA NA NA hsa-miR-125a-3p STAT4 -0.372794471295036 0.000941729459601642 2.1735809836722 2.01683302706799e-48 miRanda -0.334383629730964 7.25051370584879e-05 NA NA NA hsa-miR-125a-5p STAT4 -0.561874059994802 7.3931856356891e-13 2.1735809836722 2.01683302706799e-48 miRanda -0.865907544014713 4.19453301006747e-14 NA NA NA hsa-miR-127-5p STAT4 -1.33574359249785 5.73079880594981e-13 2.1735809836722 2.01683302706799e-48 PITA -0.205394942247123 3.08785692172695e-05 NA NA NA hsa-miR-139-5p STAT4 -0.704802495091118 2.36904108453776e-06 2.1735809836722 2.01683302706799e-48 miRanda -0.342614233583447 3.30568228010364e-08 NA NA NA hsa-miR-141-3p STAT4 -5.87110686537457 1.20877726722907e-85 2.1735809836722 2.01683302706799e-48 MirTarget;TargetScan -0.28772259142128 4.95759897430297e-40 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 -1.43409013664263 2.00188483717828e-20 2.1735809836722 2.01683302706799e-48 MirTarget -0.339781368354954 2.21896803441986e-09 NA NA NA hsa-miR-362-5p STAT6 -2.72767654824605 1.34821749679113e-49 0.369913363717725 2.10565058428813e-12 miRNATAP -0.105148265122603 2.65442985250841e-15 NA NA NA hsa-miR-142-3p TSLP 1.88928758773299 2.72985643829893e-22 -1.83676499482532 3.11985723478649e-19 miRanda -0.21864916695708 0.000131607080565115 NA NA NA hsa-miR-338-3p TSLP 0.906250377628867 2.76970900371139e-15 -1.83676499482532 3.11985723478649e-19 miRanda -0.396080799960524 7.05581146993884e-05 NA NA NA hsa-miR-340-5p TSLP 1.14479851941741 2.91936881701444e-15 -1.83676499482532 3.11985723478649e-19 mirMAP -0.272022212542862 0.000562174418582891 NA NA NA hsa-miR-590-3p TSLP 1.13702599385212 3.53435739887793e-22 -1.83676499482532 3.11985723478649e-19 miRanda;mirMAP -0.458019648171476 1.32410634418956e-06 NA NA NA