miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-let-7a-5p HRAS -0.328069937201898 0.000464344093744051 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.411742589318827 6.60009421951558e-10 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.959013717270803 5.95127281258643e-11 0.80680940319204 2.11618137601331e-10 miRTarBase -0.270772577779286 5.9733154777202e-11 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -0.584123869220553 0.000907217687997436 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.141161766298964 7.30370553951274e-05 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-542-3p JMJD7-PLA2G4B -1.31351015149842 3.64642423288576e-22 0.293448490781786 0.00123679425607597 miRNATAP -0.122126258868508 7.88924194144572e-05 NA NA NA hsa-miR-149-5p KDR -0.317176971910036 0.187207559733877 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.161937905853182 1.36302184666799e-05 NA NA NA hsa-miR-15a-5p KDR 0.349521211668244 0.000770735998804736 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.372756033627348 1.49275800717172e-05 NA NA NA hsa-miR-15b-5p KDR 0.230566941413564 0.0824765001857479 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.3391651854872 4.33957562686082e-07 NA NA NA hsa-miR-200c-3p KDR -0.104675615392797 0.716957669484981 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.116520342266903 0.00016541089831424 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-338-3p KDR 0.543135607704581 0.00461167747143826 -0.806222400057247 9.66990863598643e-06 PITA;miRanda -0.124638389203913 0.00756237946861911 NA NA NA hsa-miR-590-5p KDR -0.103355559980404 0.310027295317092 -0.806222400057247 9.66990863598643e-06 miRanda -0.641615310224899 1.28069025499026e-13 NA NA NA hsa-miR-618 KDR 0.13539895350352 0.517145913114103 -0.806222400057247 9.66990863598643e-06 PITA -0.135808208561215 0.00224740471076939 NA NA NA hsa-miR-140-3p KRAS 0.546012239205329 4.84578261098777e-11 -0.338081744192936 0.00043842779003105 MirTarget -0.247198429138234 9.22756583574077e-06 NA NA NA hsa-miR-16-1-3p KRAS 0.392360028038559 0.00112481918108198 -0.338081744192936 0.00043842779003105 mirMAP -0.114704330599848 0.00330327136149234 NA NA NA hsa-miR-193a-3p KRAS -0.117675551589896 0.309391958208578 -0.338081744192936 0.00043842779003105 MirTarget;miRanda;miRNATAP -0.128182356310374 0.00170700856743147 NA NA NA hsa-miR-193b-3p KRAS -0.166697207281748 0.272022543069482 -0.338081744192936 0.00043842779003105 miRNAWalker2_validate;MirTarget;miRNATAP -0.120510531869791 9.78248377856047e-05 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-30d-3p KRAS -0.120562286038759 0.329549534782125 -0.338081744192936 0.00043842779003105 MirTarget;miRNATAP -0.132565215112955 0.000512493362671086 NA NA NA hsa-miR-532-5p KRAS 1.02729546510601 9.93318913966636e-16 -0.338081744192936 0.00043842779003105 MirTarget;PITA;miRNATAP -0.137739612561571 0.000100604507963156 NA NA NA hsa-miR-140-3p MAP2K1 0.546012239205329 4.84578261098777e-11 -1.22814648702538 4.27448032410174e-41 PITA -0.381987666476187 3.26697824928144e-11 NA NA NA hsa-miR-34a-5p MAP2K1 1.03694231790865 5.74864019540594e-14 -1.22814648702538 4.27448032410174e-41 miRNAWalker2_validate;miRTarBase -0.229470281840033 1.32655977381036e-11 NA NA NA hsa-miR-361-5p MAP2K1 0.233202959858696 0.00961572812255327 -1.22814648702538 4.27448032410174e-41 miRanda -0.180575442044722 0.00107072926955335 NA NA NA hsa-miR-501-5p MAP2K1 1.15231083477882 2.98906150004088e-10 -1.22814648702538 4.27448032410174e-41 PITA -0.144135390798289 3.07397683406163e-08 NA NA NA hsa-let-7b-5p MAP2K2 -0.959013717270803 5.95127281258643e-11 0.626002935787801 2.22116323165311e-10 miRNAWalker2_validate -0.179048006528372 3.03569472992354e-08 NA NA NA hsa-miR-122-5p MAPK11 -1.23907441373955 4.42181244888642e-06 1.21323727189264 5.55548436625349e-12 miRNAWalker2_validate;miRTarBase -0.10214514237859 0.00150685569234902 NA NA NA hsa-miR-27a-3p MAPK14 -0.370807380415112 0.00875721956202713 -0.144548626010916 0.0495454672602603 MirTarget;miRNATAP -0.141879704151399 1.17885364887775e-08 NA NA NA hsa-miR-27b-5p MAPKAPK2 -0.084323722931086 0.480868599074588 0.541891587314344 7.22097315323501e-09 mirMAP -0.185470034671812 1.62440858476697e-06 NA NA NA hsa-miR-320a MAPKAPK2 0.325285936317332 0.0221415065838824 0.541891587314344 7.22097315323501e-09 miRanda -0.107439527461255 0.000979262051929608 NA NA NA hsa-miR-486-5p MAPKAPK2 -1.77766890600022 2.9071717929922e-14 0.541891587314344 7.22097315323501e-09 miRanda -0.101354332717813 8.58450817232234e-08 NA NA NA hsa-miR-148b-3p NFAT5 0.266862251671911 0.00185271302045935 -0.326144498869474 0.00164314559569324 miRNATAP -0.209618507772718 0.000426872096110993 NA NA NA hsa-miR-17-3p NFAT5 0.410352776142368 0.00422200500748636 -0.326144498869474 0.00164314559569324 mirMAP -0.104599542268839 0.00299701612631111 NA NA NA hsa-miR-192-3p NFAT5 -0.6401165114007 0.000266272092403814 -0.326144498869474 0.00164314559569324 MirTarget;miRNATAP -0.128669502769738 6.06524882230981e-06 NA NA NA hsa-miR-193a-3p NFAT5 -0.117675551589896 0.309391958208578 -0.326144498869474 0.00164314559569324 miRanda -0.164695361244703 0.00017397882324283 NA NA NA hsa-miR-194-3p NFAT5 -0.772747277805343 2.9537465170191e-05 -0.326144498869474 0.00164314559569324 miRNATAP -0.111726483279078 3.42120115644121e-05 NA NA NA hsa-miR-194-5p NFAT5 -0.292530160992458 0.0996141384876663 -0.326144498869474 0.00164314559569324 miRNATAP -0.121386239180467 1.81500128575235e-05 NA NA NA hsa-miR-21-5p NFAT5 1.51084295924322 1.54551622173259e-34 -0.326144498869474 0.00164314559569324 miRNAWalker2_validate;mirMAP -0.110763353790018 0.00341649802767152 NA NA NA hsa-miR-30d-5p NFAT5 0.718283816348023 2.47422074061352e-08 -0.326144498869474 0.00164314559569324 MirTarget;miRNATAP -0.100982909052041 0.00926486855231398 NA NA NA hsa-miR-362-5p NFAT5 0.717921690799312 1.68392734504524e-05 -0.326144498869474 0.00164314559569324 mirMAP -0.104218483552879 0.000512788061950843 NA NA NA hsa-miR-548j-5p NFAT5 0.251239647701947 0.171361975450222 -0.326144498869474 0.00164314559569324 MirTarget -0.114891906111678 4.99601526011913e-05 NA NA NA hsa-miR-885-5p NFAT5 -0.940994379567566 0.00118729865914986 -0.326144498869474 0.00164314559569324 PITA -0.136348025989459 3.53390243312021e-16 NA NA NA hsa-miR-455-5p NFATC1 -0.270546034117157 0.0581320703577731 -0.746396319507337 4.35096501526645e-05 miRanda -0.308343970820935 7.69222772176338e-07 NA NA NA hsa-miR-29a-5p NFATC2 -0.113555908626946 0.349622266470788 -1.87041062792181 1.43414339850833e-07 mirMAP;miRNATAP -0.583625441866098 5.86022160251471e-05 NA NA NA hsa-miR-30d-5p NFATC2 0.718283816348023 2.47422074061352e-08 -1.87041062792181 1.43414339850833e-07 MirTarget;mirMAP -0.429558488883224 0.00143308759494954 NA NA NA hsa-miR-15a-5p NFATC3 0.349521211668244 0.000770735998804736 -0.644444487566839 5.42635056668801e-13 MirTarget;miRNATAP -0.140535010330653 0.0011067840013694 NA NA NA hsa-miR-185-5p NFATC3 0.480006257154717 6.35758891340152e-07 -0.644444487566839 5.42635056668801e-13 MirTarget;miRNATAP -0.179084861620697 0.000100696521869942 NA NA NA hsa-miR-222-3p NFATC3 1.08574156066353 1.76407192348131e-11 -0.644444487566839 5.42635056668801e-13 MirTarget;miRNATAP -0.132741702448246 6.9873783779618e-07 NA NA NA hsa-miR-30d-5p NFATC3 0.718283816348023 2.47422074061352e-08 -0.644444487566839 5.42635056668801e-13 MirTarget;miRNATAP -0.107813608303496 0.00162247650109074 NA NA NA hsa-miR-324-3p NFATC3 0.260348469146494 0.0506141704203545 -0.644444487566839 5.42635056668801e-13 miRNAWalker2_validate -0.114816122875489 0.000628244289295564 NA NA NA hsa-miR-335-3p NFATC3 -0.275199247483111 0.106629165248783 -0.644444487566839 5.42635056668801e-13 mirMAP -0.129711946659763 5.8123470467313e-07 NA NA NA hsa-miR-339-5p NFATC3 0.280589919878422 0.0355660282647215 -0.644444487566839 5.42635056668801e-13 miRanda -0.169042767427976 3.57074145767803e-07 NA NA NA hsa-miR-362-3p NFATC3 0.814007335895913 2.00108618836568e-09 -0.644444487566839 5.42635056668801e-13 miRanda -0.165414246315846 2.41507380316181e-07 NA NA NA hsa-miR-589-3p NFATC3 1.16846704028095 5.88525574424201e-11 -0.644444487566839 5.42635056668801e-13 mirMAP -0.152120593205245 5.77499693309063e-10 NA NA NA hsa-miR-125b-5p NFATC4 -1.35767721102906 1.16564617395164e-18 0.864010892322999 1.90169048902368e-05 mirMAP -0.224809010069414 0.000268845801695449 NA NA NA hsa-miR-130b-5p NFATC4 0.170599813152408 0.337611586432771 0.864010892322999 1.90169048902368e-05 mirMAP -0.223334355722899 6.08007516287365e-05 NA NA NA hsa-miR-29a-3p NFATC4 -0.856762511178136 4.65330336378459e-12 0.864010892322999 1.90169048902368e-05 miRNATAP -0.210278806007119 0.00743486328282441 NA NA NA hsa-miR-3607-3p NFATC4 -2.15518588554493 1.03390728226728e-23 0.864010892322999 1.90169048902368e-05 miRNATAP -0.174472801573825 6.00001387189594e-05 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.428561469405594 6.6035585844222e-05 0.301156333096785 0.000285671613438218 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.4795885711477 6.47308361543414e-16 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.856762511178136 4.65330336378459e-12 0.301156333096785 0.000285671613438218 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.348885528720517 0.0121441341291285 0.301156333096785 0.000285671613438218 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.485807855553031 0.000732553249798598 0.301156333096785 0.000285671613438218 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-106b-5p PLA2G12A 0.648901865047099 8.24870862047885e-09 -0.791023748042462 1.18231931629012e-15 mirMAP -0.266014267647959 5.9212435860407e-10 NA NA NA hsa-miR-140-5p PLA2G12A -0.220106443070144 0.0140713197101242 -0.791023748042462 1.18231931629012e-15 miRanda -0.148237117501735 0.00839228705095135 NA NA NA hsa-miR-17-5p PLA2G12A 0.698861147045461 2.43854106455398e-05 -0.791023748042462 1.18231931629012e-15 mirMAP -0.156166087311117 1.18493997052615e-07 NA NA NA hsa-miR-181a-5p PLA2G12A 0.250113435902954 0.0551933249319293 -0.791023748042462 1.18231931629012e-15 mirMAP -0.193778811048191 3.19565578842397e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 0.488256489401108 0.00105321129419701 -0.791023748042462 1.18231931629012e-15 mirMAP -0.187398478397273 1.16778168992629e-08 NA NA NA hsa-miR-20a-5p PLA2G12A 0.854326758727003 5.04256669663285e-07 -0.791023748042462 1.18231931629012e-15 mirMAP -0.130236012494097 5.73845333718432e-06 NA NA NA hsa-miR-32-3p PLA2G12A 0.219109440121582 0.207217051619543 -0.791023748042462 1.18231931629012e-15 mirMAP -0.100135809509177 0.000715271422667235 NA NA NA hsa-miR-362-3p PLA2G12A 0.814007335895913 2.00108618836568e-09 -0.791023748042462 1.18231931629012e-15 miRanda -0.13534064202416 0.000168490865417192 NA NA NA hsa-miR-501-5p PLA2G12A 1.15231083477882 2.98906150004088e-10 -0.791023748042462 1.18231931629012e-15 miRNATAP -0.159698924847702 1.1258030900796e-09 NA NA NA hsa-miR-589-3p PLA2G12A 1.16846704028095 5.88525574424201e-11 -0.791023748042462 1.18231931629012e-15 mirMAP -0.18597386225482 8.57790590041378e-12 NA NA NA hsa-miR-625-3p PLA2G12A 0.242249841316603 0.181227779755078 -0.791023748042462 1.18231931629012e-15 mirMAP -0.135161844446821 6.99056150075446e-07 NA NA NA hsa-miR-92b-3p PLA2G12A 0.220374930803974 0.296187538889092 -0.791023748042462 1.18231931629012e-15 miRNAWalker2_validate -0.10091652542866 1.70520826049974e-05 NA NA NA hsa-miR-93-5p PLA2G12A 1.39518349670953 2.84167728726712e-25 -0.791023748042462 1.18231931629012e-15 mirMAP -0.31642455552352 2.26982563682874e-21 NA NA NA hsa-miR-1976 PLA2G12B -0.431472440543166 0.00324575010550946 -0.709043082048637 0.0159106564464709 MirTarget -0.454863439085783 2.8222658320172e-06 NA NA NA hsa-miR-28-5p PLA2G1B -0.430964830599964 2.67367257252925e-06 1.11218092480272 0.00100002877020529 miRanda -0.522539189337601 0.00380748163736023 NA NA NA hsa-miR-361-5p PLA2G2A 0.233202959858696 0.00961572812255327 -2.63355537093474 0.000185160572420402 miRanda -2.32115808913069 1.20165686326271e-09 NA NA NA hsa-miR-30c-2-3p PLA2G2D -1.39811819128587 3.66376924527665e-15 -0.885146609200152 0.0330899260748063 mirMAP -0.308953568974045 0.00508340182787345 NA NA NA hsa-miR-361-5p PLA2G4A 0.233202959858696 0.00961572812255327 -1.51782818803861 3.95172010500953e-09 miRanda -0.519567336876991 0.000291415934911842 NA NA NA hsa-miR-362-3p PLA2G4A 0.814007335895913 2.00108618836568e-09 -1.51782818803861 3.95172010500953e-09 miRanda -0.270784488699881 0.0035520338530453 NA NA NA hsa-miR-128-3p PLA2G5 0.289735108018712 0.0114419474207889 -1.41944375217114 6.19629138768315e-10 miRNAWalker2_validate -0.27681378716713 0.00574201580029315 NA NA NA hsa-miR-361-5p PLA2G5 0.233202959858696 0.00961572812255327 -1.41944375217114 6.19629138768315e-10 miRanda -0.491895928491166 0.000117994720629655 NA NA NA hsa-miR-589-3p PLA2G5 1.16846704028095 5.88525574424201e-11 -1.41944375217114 6.19629138768315e-10 MirTarget -0.251533188441071 7.7546591228512e-05 NA NA NA hsa-miR-590-5p PLA2G5 -0.103355559980404 0.310027295317092 -1.41944375217114 6.19629138768315e-10 miRanda -0.405592480648136 0.000336021206784067 NA NA NA hsa-miR-30a-3p PLA2G6 -1.52720594401486 1.3830066075708e-17 1.15734672432699 4.00326986916457e-16 miRNATAP -0.2445503962837 1.00180247722334e-10 NA NA NA hsa-miR-101-3p PLCG1 -1.48176407980989 3.98950707385704e-31 0.954675597841582 9.37413206548639e-17 miRNATAP -0.22440743759437 7.91378554146212e-08 NA NA NA hsa-miR-106b-5p PPP3CA 0.648901865047099 8.24870862047885e-09 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.191067063648852 3.69747843513626e-08 NA NA NA hsa-miR-17-3p PPP3CA 0.410352776142368 0.00422200500748636 -0.536165287387848 2.77787023947662e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-17-5p PPP3CA 0.698861147045461 2.43854106455398e-05 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143640408234319 1.13035407609444e-09 NA NA NA hsa-miR-20a-5p PPP3CA 0.854326758727003 5.04256669663285e-07 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-21-5p PPP3CA 1.51084295924322 1.54551622173259e-34 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143821297395015 1.2695170248385e-06 NA NA NA hsa-miR-30d-5p PPP3CA 0.718283816348023 2.47422074061352e-08 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.146138892286555 1.56191209956503e-06 NA NA NA hsa-miR-361-5p PPP3CA 0.233202959858696 0.00961572812255327 -0.536165287387848 2.77787023947662e-11 miRanda -0.145335005010698 0.00120607782460008 NA NA NA hsa-miR-501-3p PPP3CA 0.999540908940094 2.77358485581974e-11 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.169069809996199 3.5765991379194e-11 NA NA NA hsa-miR-502-3p PPP3CA 0.659598854007546 3.01316453996423e-08 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.21026132041502 1.15384439121552e-10 NA NA NA hsa-miR-589-3p PPP3CA 1.16846704028095 5.88525574424201e-11 -0.536165287387848 2.77787023947662e-11 MirTarget -0.121264895830011 4.18270966031286e-08 NA NA NA hsa-miR-93-3p PPP3CA 0.402821129107592 0.00131324842735588 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143288165599429 6.27730698290466e-06 NA NA NA hsa-miR-93-5p PPP3CA 1.39518349670953 2.84167728726712e-25 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.206462809599041 4.19505348801646e-14 NA NA NA hsa-miR-361-5p PPP3CC 0.233202959858696 0.00961572812255327 -0.442598423475551 4.06646193924103e-07 miRanda -0.159719077024821 0.00091909551904825 NA NA NA hsa-miR-106b-5p PPP3R1 0.648901865047099 8.24870862047885e-09 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.138661227962938 5.82082557526804e-07 NA NA NA hsa-miR-181a-5p PPP3R1 0.250113435902954 0.0551933249319293 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181c-5p PPP3R1 -0.00639394152050299 0.969127212255928 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.116625763794141 9.00795108119744e-10 NA NA NA hsa-miR-24-3p PPP3R1 -0.257825594021966 0.00689742600215061 -0.348267739030591 8.30932335829799e-08 miRNAWalker2_validate -0.106343408108425 0.00160055709787487 NA NA NA hsa-miR-27a-3p PPP3R1 -0.370807380415112 0.00875721956202713 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.117734120643401 1.31409589262749e-07 NA NA NA hsa-miR-93-5p PPP3R1 1.39518349670953 2.84167728726712e-25 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.108796059262154 9.63915967695639e-07 NA NA NA hsa-miR-142-5p PRKCA -1.44575553250033 1.18797044680592e-13 0.662827897377551 1.5305893364122e-08 mirMAP -0.253211662252116 4.3295868991415e-20 NA NA NA hsa-miR-146a-5p PRKCA -0.742958238440575 0.000765983177482633 0.662827897377551 1.5305893364122e-08 mirMAP -0.137245496572864 1.03630471721186e-07 NA NA NA hsa-miR-150-5p PRKCA -1.14624309254329 1.51365525978726e-06 0.662827897377551 1.5305893364122e-08 mirMAP -0.222341791889769 1.93250353571038e-22 NA NA NA hsa-miR-181a-5p PRKCA 0.250113435902954 0.0551933249319293 0.662827897377551 1.5305893364122e-08 mirMAP -0.254408568412877 7.16377375327665e-09 NA NA NA hsa-miR-181b-5p PRKCA 0.488256489401108 0.00105321129419701 0.662827897377551 1.5305893364122e-08 mirMAP -0.205095445188407 8.90870928470555e-08 NA NA NA hsa-miR-181c-5p PRKCA -0.00639394152050299 0.969127212255928 0.662827897377551 1.5305893364122e-08 mirMAP -0.183322604105065 1.38074332954132e-07 NA NA NA hsa-miR-1976 PRKCA -0.431472440543166 0.00324575010550946 0.662827897377551 1.5305893364122e-08 miRNATAP -0.183056349310667 3.0318716310551e-06 NA NA NA hsa-miR-218-5p PRKCA -0.500091158894849 0.0398595700240766 0.662827897377551 1.5305893364122e-08 mirMAP -0.148170646737725 2.1349888993316e-10 NA NA NA hsa-miR-22-5p PRKCA -0.630365901263172 3.32415348030414e-05 0.662827897377551 1.5305893364122e-08 mirMAP -0.251052842185981 1.31444858545747e-11 NA NA NA hsa-miR-2355-3p PRKCA -0.471227472721651 0.00718598113738346 0.662827897377551 1.5305893364122e-08 mirMAP -0.157103097222143 1.75080235522893e-06 NA NA NA hsa-miR-24-2-5p PRKCA -0.570999109789414 0.000447358572601571 0.662827897377551 1.5305893364122e-08 miRNAWalker2_validate -0.215395057998791 6.57823794606976e-10 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-29b-2-5p PRKCA -0.223258653034772 0.084306146519938 0.662827897377551 1.5305893364122e-08 mirMAP -0.18197054047472 4.89908312952123e-05 NA NA NA hsa-miR-330-3p PRKCA -0.332364259424489 0.0316051913061459 0.662827897377551 1.5305893364122e-08 mirMAP -0.210648698518416 2.68188227678048e-08 NA NA NA hsa-miR-381-3p PRKCA -1.11307533852141 4.70760087251745e-06 0.662827897377551 1.5305893364122e-08 mirMAP -0.100091563011784 1.9205952275757e-05 NA NA NA hsa-miR-450b-5p PRKCA -1.34333360369432 2.68386079790462e-17 0.662827897377551 1.5305893364122e-08 PITA;mirMAP;miRNATAP -0.224507062259025 6.89309401647265e-11 NA NA NA hsa-miR-495-3p PRKCA -0.751193061269953 0.00388779118736635 0.662827897377551 1.5305893364122e-08 mirMAP -0.103006977344404 3.01377161842223e-06 NA NA NA hsa-miR-505-3p PRKCA -1.20027021591555 1.27927500175937e-13 0.662827897377551 1.5305893364122e-08 miRNAWalker2_validate -0.100809044268482 0.00372474801967268 NA NA NA hsa-miR-654-3p PRKCA -1.72200544726291 6.91948971554614e-10 0.662827897377551 1.5305893364122e-08 mirMAP -0.104555302741979 1.91014801150244e-07 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-23b-3p PRKCB -0.530561587109023 5.43807206823652e-07 -1.62067363753233 3.76201992658756e-13 mirMAP -0.286204121948097 0.00657996649038471 NA NA NA hsa-miR-30d-5p PRKCB 0.718283816348023 2.47422074061352e-08 -1.62067363753233 3.76201992658756e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-3p PRKCB 1.16846704028095 5.88525574424201e-11 -1.62067363753233 3.76201992658756e-13 mirMAP -0.228692909978861 0.000252673885842927 NA NA NA hsa-miR-589-5p PRKCB 1.18593770505086 1.01781241960531e-22 -1.62067363753233 3.76201992658756e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-616-5p PRKCB 0.150569904638223 0.402836556304524 -1.62067363753233 3.76201992658756e-13 mirMAP -0.245704989615516 7.89898683278172e-05 NA NA NA hsa-miR-664a-3p PRKCB 0.485807855553031 0.000732553249798598 -1.62067363753233 3.76201992658756e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-128-3p PTGS2 0.289735108018712 0.0114419474207889 -3.17983469073364 8.43589575129768e-28 miRNAWalker2_validate -0.565857106559088 1.91311220648484e-05 NA NA NA hsa-miR-17-5p PTGS2 0.698861147045461 2.43854106455398e-05 -3.17983469073364 8.43589575129768e-28 miRNAWalker2_validate -0.402874642470991 8.28654951955154e-06 NA NA NA hsa-miR-32-3p PTGS2 0.219109440121582 0.207217051619543 -3.17983469073364 8.43589575129768e-28 mirMAP -0.233988875943054 0.00973882078756686 NA NA NA hsa-miR-362-3p PTGS2 0.814007335895913 2.00108618836568e-09 -3.17983469073364 8.43589575129768e-28 miRanda -0.434374975202986 7.41678169385338e-05 NA NA NA hsa-miR-374a-5p PTGS2 0.016390363747302 0.869784217438621 -3.17983469073364 8.43589575129768e-28 mirMAP -0.468562364529729 0.00228454527511996 NA NA NA hsa-miR-616-5p PTGS2 0.150569904638223 0.402836556304524 -3.17983469073364 8.43589575129768e-28 mirMAP -0.414764514685372 7.76498063414914e-07 NA NA NA hsa-let-7c-5p PTK2 -1.70744661345097 2.87934212005942e-20 0.592116034898139 1.42360483588582e-09 miRNAWalker2_validate -0.111526582483996 6.85487252665759e-06 NA NA NA hsa-miR-140-5p PTK2 -0.220106443070144 0.0140713197101242 0.592116034898139 1.42360483588582e-09 miRanda -0.143491653583679 0.00881810175828342 NA NA NA hsa-miR-193a-3p PTK2 -0.117675551589896 0.309391958208578 0.592116034898139 1.42360483588582e-09 miRNAWalker2_validate;miRanda -0.119325883264928 0.00471634522445647 NA NA NA hsa-miR-505-3p PTK2 -1.20027021591555 1.27927500175937e-13 0.592116034898139 1.42360483588582e-09 MirTarget;miRNATAP -0.118958314234155 3.90333340892144e-05 NA NA NA hsa-miR-590-3p PTK2 -0.473167498047808 1.76652934637227e-05 0.592116034898139 1.42360483588582e-09 miRanda -0.141997163320001 0.00120758249564418 NA NA NA hsa-miR-101-3p RAC1 -1.48176407980989 3.98950707385704e-31 0.216579201672401 0.00293326905874306 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.166697207281748 0.272022543069482 -0.540909479889968 0.00736745718035675 miRNAWalker2_validate -0.246231671968469 0.000150422998204956 NA NA NA hsa-miR-125a-5p RAC3 -0.91219969372382 1.38256246489548e-07 0.670983769148776 0.00109278799508602 PITA -0.323616313906469 9.94727754352694e-09 NA NA NA hsa-miR-342-3p RAC3 -0.319677314984262 0.0449813878317147 0.670983769148776 0.00109278799508602 miRanda -0.17569839241443 0.00542104916104601 NA NA NA hsa-miR-107 SH2D2A 0.241662461253461 0.0170788899505389 -0.262714761760894 0.296957196758006 PITA;miRanda;miRNATAP -0.362514053333863 0.002965550669113 NA NA NA hsa-miR-194-3p SH2D2A -0.772747277805343 2.9537465170191e-05 -0.262714761760894 0.296957196758006 MirTarget -0.391163844249121 1.44766119051929e-09 NA NA NA hsa-miR-186-5p SHC2 -0.060103391373687 0.535288717081205 -0.454671061034392 0.0116778043545466 miRNAWalker2_validate -0.425744197135689 3.04991486566084e-06 NA NA NA hsa-miR-130b-5p SRC 0.170599813152408 0.337611586432771 0.766173851969095 0.000257254769528933 mirMAP -0.250899755889788 1.2890211370399e-05 NA NA NA hsa-miR-144-3p SRC -2.97536914478815 6.00546047309683e-28 0.766173851969095 0.000257254769528933 MirTarget -0.131083807006654 0.000195420552491251 NA NA NA hsa-miR-193b-3p SRC -0.166697207281748 0.272022543069482 0.766173851969095 0.000257254769528933 mirMAP -0.29079891629134 1.67067983967046e-05 NA NA NA hsa-miR-195-5p SRC -1.85907534356434 1.47434041676402e-22 0.766173851969095 0.000257254769528933 mirMAP -0.291201965854594 7.75311466804379e-09 NA NA NA hsa-miR-23b-3p SRC -0.530561587109023 5.43807206823652e-07 0.766173851969095 0.000257254769528933 miRNAWalker2_validate;miRTarBase -0.336904358943492 0.000473901465573634 23074286 miR 23b represses proto oncogene Src kinase and functions as methylation silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer; We showed that proto-oncogene Src kinase and Akt are direct targets of miR-23b; Depletion of Src by RNA interference conferred similar functional effects as that of miR-23b reconstitution; miR-23b expression caused a dramatic decrease in tumor growth in nude mice and attenuated Src expression in excised tumors compared with a control miR prostate cancer hsa-miR-548b-3p SRC -0.0203576084717134 0.930819503166956 0.766173851969095 0.000257254769528933 mirMAP -0.121115266342296 0.00648707025136746 NA NA NA hsa-miR-150-5p VEGFA -1.14624309254329 1.51365525978726e-06 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase -0.114666527453602 2.4663414134099e-07 NA NA NA hsa-miR-29b-2-5p VEGFA -0.223258653034772 0.084306146519938 0.0263183839451075 0.81382635000524 MirTarget -0.132006150652748 0.00171675395806506 NA NA NA hsa-miR-29b-3p VEGFA -0.348885528720517 0.0121441341291285 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase;MirTarget -0.125790856471025 0.00126089778683366 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer