miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p A2ML1 -3.25846663863766 2.62018989415003e-112 -0.0466542645811558 0.909880156985488 miRanda -0.251517758397988 0.00301165361367376 NA NA NA hsa-miR-182-5p AASS 2.36408084103818 2.60011457600281e-72 -1.98070791112723 2.04633511350514e-56 MirTarget -0.320524453456698 6.85742472275677e-25 NA NA NA hsa-miR-183-5p ABCA1 2.95681814393872 1.09965777344285e-92 -1.41003867527676 8.01229714514919e-38 MirTarget;miRNATAP -0.225573029123914 1.38692752003874e-21 26935154 MiR 183 functions as an oncogene by targeting ABCA1 in colon cancer; We found that miR-183 targets the 3'UTR of ABCA1 mRNA; Subsequent experiments confirmed that miR-183 degraded ABCA1 mRNA in the colon cancer cells; Thus we conclude that miR-183 promotes proliferation and inhibits apoptosis by degrading ABCA1 in colon cancer colon cancer hsa-miR-200a-3p ABCA1 2.55218480823434 2.96135446816238e-51 -1.41003867527676 8.01229714514919e-38 mirMAP -0.253171097399316 2.80423350246485e-33 NA NA NA hsa-miR-200b-3p ABCA1 2.11744072703209 1.66710572104191e-43 -1.41003867527676 8.01229714514919e-38 TargetScan -0.283811342028782 7.93574234190737e-34 NA NA NA hsa-miR-21-5p ABCA1 2.32007501846389 3.08394781855554e-137 -1.41003867527676 8.01229714514919e-38 mirMAP -0.315513734860042 2.292461338917e-19 NA NA NA hsa-miR-429 ABCA1 2.84108892259147 3.88520896426515e-64 -1.41003867527676 8.01229714514919e-38 miRNATAP -0.25750208898103 5.76622185123432e-35 NA NA NA hsa-miR-96-5p ABCA1 3.24596558166606 1.92296159041707e-98 -1.41003867527676 8.01229714514919e-38 TargetScan;miRNATAP -0.259252481944741 1.92235249922872e-32 NA NA NA hsa-miR-200b-3p ABCA10 2.11744072703209 1.66710572104191e-43 -4.62619452417002 7.14146439742034e-87 mirMAP -0.53591695349654 3.28726725718492e-23 NA NA NA hsa-miR-21-3p ABCA10 2.17476065946878 5.15299442583591e-75 -4.62619452417002 7.14146439742034e-87 mirMAP -0.989340390967255 3.39139098487483e-53 NA NA NA hsa-miR-21-5p ABCA10 2.32007501846389 3.08394781855554e-137 -4.62619452417002 7.14146439742034e-87 mirMAP -1.05427906803444 2.94764840103498e-42 NA NA NA hsa-miR-429 ABCA10 2.84108892259147 3.88520896426515e-64 -4.62619452417002 7.14146439742034e-87 mirMAP -0.631970568441949 4.8734327007258e-41 NA NA NA hsa-miR-335-5p ABCA12 -2.61355235628987 2.6462884165886e-51 1.78416478403449 5.9417521404362e-07 miRNAWalker2_validate -0.173037297958555 0.00965063793179321 NA NA NA hsa-miR-429 ABCA5 2.84108892259147 3.88520896426515e-64 -1.91762280024646 1.74418520972105e-50 miRanda -0.246061372878738 1.92040427389237e-22 NA NA NA hsa-miR-183-5p ABCA8 2.95681814393872 1.09965777344285e-92 -5.12296245421974 8.80430177796252e-60 MirTarget -0.952184937152352 4.45807631409907e-45 NA NA NA hsa-miR-375 ABCA8 2.09893673049766 1.68351780396203e-16 -5.12296245421974 8.80430177796252e-60 miRanda -0.198990481692328 7.91519287617365e-06 NA NA NA hsa-miR-429 ABCA9 2.84108892259147 3.88520896426515e-64 -4.44082673153672 7.25324599082181e-78 miRanda -0.692573236845302 1.22861426429753e-49 NA NA NA hsa-miR-429 ABCB1 2.84108892259147 3.88520896426515e-64 -2.55486008652248 1.60164116486385e-43 miRanda -0.410423646395773 1.04410007346123e-30 NA NA NA hsa-miR-429 ABCB4 2.84108892259147 3.88520896426515e-64 0.378178548932909 0.00109605051412751 miRanda -0.104702321525289 1.71958694173397e-06 NA NA NA hsa-miR-429 ABCB5 2.84108892259147 3.88520896426515e-64 -4.84771469709344 1.8858945581338e-68 miRanda -0.751404666880899 1.59684200806777e-43 NA NA NA hsa-miR-335-5p ABCB8 -2.61355235628987 2.6462884165886e-51 1.12746974023582 1.19961062683707e-47 mirMAP -0.120171789143879 1.53539596153348e-15 NA NA NA hsa-miR-335-5p ABCB9 -2.61355235628987 2.6462884165886e-51 0.947933279325208 1.1543853299555e-17 miRNAWalker2_validate -0.141202983689412 1.04003626241481e-11 NA NA NA hsa-miR-139-5p ABCC5 -3.25846663863766 2.62018989415003e-112 0.797302989981293 1.93030507748535e-11 miRanda;mirMAP -0.161350900083425 4.49114377914826e-11 NA NA NA hsa-miR-224-5p ABCC5 -2.22249420723892 1.07787949391113e-18 0.797302989981293 1.93030507748535e-11 mirMAP -0.119218322824553 3.91866151312107e-14 NA NA NA hsa-miR-429 ABCC6P1 2.84108892259147 3.88520896426515e-64 -2.43565389867226 2.35342504469537e-22 miRanda -0.331803909019876 5.67397474650085e-12 NA NA NA hsa-miR-429 ABCC9 2.84108892259147 3.88520896426515e-64 -2.42039579420726 8.28657220337329e-55 miRanda;miRNATAP -0.463880645642377 4.11650113738825e-56 NA NA NA hsa-miR-429 ABCD2 2.84108892259147 3.88520896426515e-64 -4.13202445404554 7.27940460027266e-72 miRanda -0.617753382202644 4.17829111662608e-42 NA NA NA hsa-miR-429 ABCG2 2.84108892259147 3.88520896426515e-64 -1.95434195130869 1.81711422911522e-34 miRanda -0.348683008412805 2.21791345238672e-30 NA NA NA hsa-miR-224-5p ABHD2 -2.22249420723892 1.07787949391113e-18 0.450213534981843 0.000527417369441251 mirMAP -0.144890787859168 1.48807898446435e-17 NA NA NA hsa-miR-452-5p ABHD2 -2.48486455572568 1.24430987974325e-33 0.450213534981843 0.000527417369441251 mirMAP -0.224241055461649 7.16006489917389e-29 NA NA NA hsa-miR-182-5p ABLIM1 2.36408084103818 2.60011457600281e-72 -1.68545359122206 2.26864125839664e-54 mirMAP;miRNATAP -0.25716775235267 1.82848023459826e-21 NA NA NA hsa-miR-139-5p ABTB2 -3.25846663863766 2.62018989415003e-112 0.0547624456447142 0.737043015665459 miRanda -0.101957769139014 0.00236225956443725 NA NA NA hsa-miR-21-3p ACAD11 2.17476065946878 5.15299442583591e-75 -1.04928106236629 6.51481830264946e-47 MirTarget -0.24230513789111 1.76668448997836e-35 NA NA NA hsa-miR-429 ACAD11 2.84108892259147 3.88520896426515e-64 -1.04928106236629 6.51481830264946e-47 miRanda -0.140605190325115 6.13534601319966e-23 NA NA NA hsa-miR-375 ACADL 2.09893673049766 1.68351780396203e-16 -5.19429156085254 1.39084260292337e-61 miRanda -0.35573006332611 6.12142933858555e-16 NA NA NA hsa-miR-429 ACADSB 2.84108892259147 3.88520896426515e-64 -0.519397273275526 0.00199932436563489 miRanda;mirMAP;miRNATAP -0.108197440170625 0.000684796398513526 NA NA NA hsa-miR-511-5p ACAN -2.27545475897362 3.84085514050558e-36 2.73236750199248 1.1619529205365e-36 MirTarget -0.108295897380675 0.00855780988379309 NA NA NA hsa-miR-21-5p ACAT1 2.32007501846389 3.08394781855554e-137 -0.751385545284676 2.05460285005042e-17 miRNAWalker2_validate -0.298691444140465 4.98274156830538e-28 NA NA NA hsa-miR-429 ACAT1 2.84108892259147 3.88520896426515e-64 -0.751385545284676 2.05460285005042e-17 miRanda -0.130041083403282 1.11097571102552e-14 NA NA NA hsa-miR-139-5p ACBD3 -3.25846663863766 2.62018989415003e-112 0.580098421132699 5.21458631253397e-18 miRanda -0.111241409961512 9.30100583814674e-16 NA NA NA hsa-miR-200b-3p ACE2 2.11744072703209 1.66710572104191e-43 -2.44666505291094 5.7620122495315e-15 TargetScan -0.306113069761062 5.51887722129256e-06 NA NA NA hsa-miR-200c-3p ACE2 2.07038651806183 6.84613386286599e-51 -2.44666505291094 5.7620122495315e-15 miRNATAP -0.318325398623016 1.75220441613177e-05 NA NA NA hsa-miR-429 ACE2 2.84108892259147 3.88520896426515e-64 -2.44666505291094 5.7620122495315e-15 miRanda;miRNATAP -0.189570583445275 0.0016819467486168 NA NA NA hsa-miR-183-5p ACER2 2.95681814393872 1.09965777344285e-92 -1.35100520224402 2.14454441218546e-15 MirTarget -0.145409633854493 6.60795705668092e-05 NA NA NA hsa-miR-96-5p ACER2 3.24596558166606 1.92296159041707e-98 -1.35100520224402 2.14454441218546e-15 TargetScan -0.180351680873502 1.1986206710796e-07 NA NA NA hsa-miR-21-5p ACER3 2.32007501846389 3.08394781855554e-137 -0.640983952679642 6.8152048477394e-09 mirMAP -0.269892772906774 3.09742643677186e-15 NA NA NA hsa-miR-429 ACER3 2.84108892259147 3.88520896426515e-64 -0.640983952679642 6.8152048477394e-09 miRanda -0.127783521168387 1.06078080737116e-09 NA NA NA hsa-miR-10b-5p ACLY -2.10996264627796 7.36811595736367e-72 0.433146089046049 1.70002256908347e-09 miRNAWalker2_validate -0.104165485377953 5.76280963648331e-08 NA NA NA hsa-miR-141-3p ACO1 2.99777540204168 1.26370498493024e-78 -1.62951665297927 9.7988966479822e-70 MirTarget;TargetScan -0.319542842463036 4.31583453848052e-71 NA NA NA hsa-miR-200a-3p ACO1 2.55218480823434 2.96135446816238e-51 -1.62951665297927 9.7988966479822e-70 MirTarget -0.256023074843234 5.21297435377469e-45 NA NA NA hsa-miR-429 ACO1 2.84108892259147 3.88520896426515e-64 -1.62951665297927 9.7988966479822e-70 miRanda -0.258874470089164 8.51877298168128e-47 NA NA NA hsa-miR-335-5p ACOT8 -2.61355235628987 2.6462884165886e-51 0.75360744392757 2.40475103703802e-25 miRNAWalker2_validate -0.110407661294438 5.32608082655676e-16 NA NA NA hsa-miR-429 ACOX1 2.84108892259147 3.88520896426515e-64 -0.606380143515434 2.77537703882283e-19 miRNATAP -0.104398769973592 4.34116875436986e-16 NA NA NA hsa-miR-429 ACOX2 2.84108892259147 3.88520896426515e-64 -0.75802583599055 0.000997948336264636 miRanda;miRNATAP -0.211175077107784 1.23114876609864e-06 NA NA NA hsa-miR-429 ACSL1 2.84108892259147 3.88520896426515e-64 -2.41224232954287 2.52997087066535e-57 miRNATAP -0.359455522766522 4.87664361865314e-34 NA NA NA hsa-miR-375 ACSL4 2.09893673049766 1.68351780396203e-16 -1.47773903295013 8.01517847091735e-37 miRNAWalker2_validate;miRanda -0.207731595995472 4.60076461290407e-42 NA NA NA hsa-miR-429 ACSL4 2.84108892259147 3.88520896426515e-64 -1.47773903295013 8.01517847091735e-37 miRanda;miRNATAP -0.262881355194771 3.01761312847269e-32 NA NA NA hsa-miR-375 ACSL5 2.09893673049766 1.68351780396203e-16 -1.27143838673724 5.87781625938312e-22 miRNATAP -0.165900152168269 1.89119530070923e-21 NA NA NA hsa-miR-224-5p ACSS1 -2.22249420723892 1.07787949391113e-18 0.383610617106346 0.00172767890652602 MirTarget -0.157750641392094 3.01905897900621e-23 NA NA NA hsa-miR-452-5p ACSS1 -2.48486455572568 1.24430987974325e-33 0.383610617106346 0.00172767890652602 MirTarget -0.159593675143779 1.1341340298918e-16 NA NA NA hsa-miR-200b-3p ACTC1 2.11744072703209 1.66710572104191e-43 -1.24903172217607 7.23611450835938e-07 MirTarget -0.358826299549212 1.57598939825919e-11 NA NA NA hsa-miR-200c-3p ACTC1 2.07038651806183 6.84613386286599e-51 -1.24903172217607 7.23611450835938e-07 MirTarget -0.450845796805972 1.03869011105321e-14 NA NA NA hsa-miR-429 ACTC1 2.84108892259147 3.88520896426515e-64 -1.24903172217607 7.23611450835938e-07 MirTarget;miRanda;miRNATAP -0.266765404486588 2.28934348031544e-08 NA NA NA hsa-miR-10b-5p ACTG1 -2.10996264627796 7.36811595736367e-72 0.705064523343649 4.55348682247055e-34 miRNAWalker2_validate;miRNATAP -0.152271048208906 2.45412318592821e-22 NA NA NA hsa-miR-145-5p ACTG1 -2.62703571936687 7.64402900188551e-88 0.705064523343649 4.55348682247055e-34 MirTarget;miRNATAP -0.120992999299289 1.16347849721028e-18 NA NA NA hsa-miR-429 ACVR1 2.84108892259147 3.88520896426515e-64 -0.462938675109919 4.22826789612895e-13 miRNATAP -0.119553302184784 1.14526847802397e-23 NA NA NA hsa-miR-96-5p ACVR1 3.24596558166606 1.92296159041707e-98 -0.462938675109919 4.22826789612895e-13 TargetScan;miRNATAP -0.100604313502428 1.25599818730201e-15 NA NA NA hsa-miR-200b-3p ACVR1C 2.11744072703209 1.66710572104191e-43 -5.20071129736289 8.81931099882978e-104 TargetScan -0.692003711219126 2.03439748086501e-35 NA NA NA hsa-miR-429 ACVR1C 2.84108892259147 3.88520896426515e-64 -5.20071129736289 8.81931099882978e-104 PITA;miRanda;miRNATAP -0.697810047692677 7.01989078734797e-46 NA NA NA hsa-miR-141-3p ACVR2A 2.99777540204168 1.26370498493024e-78 -0.964184609321378 1.30052843588401e-37 TargetScan;miRNATAP -0.161379309311092 1.25725298325859e-27 NA NA NA hsa-miR-183-5p ACVR2A 2.95681814393872 1.09965777344285e-92 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.143429776860837 1.10115003008173e-18 NA NA NA hsa-miR-200a-3p ACVR2A 2.55218480823434 2.96135446816238e-51 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.142523834102645 2.08957993508987e-22 NA NA NA hsa-miR-200b-3p ACVR2A 2.11744072703209 1.66710572104191e-43 -0.964184609321378 1.30052843588401e-37 TargetScan -0.143541862814667 1.76104677420962e-18 NA NA NA hsa-miR-200c-3p ACVR2A 2.07038651806183 6.84613386286599e-51 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.155691181802949 5.31342226529533e-18 NA NA NA hsa-miR-21-5p ACVR2A 2.32007501846389 3.08394781855554e-137 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.228019435065362 1.72805692634805e-21 NA NA NA hsa-miR-429 ACVR2A 2.84108892259147 3.88520896426515e-64 -0.964184609321378 1.30052843588401e-37 PITA;miRanda;miRNATAP -0.146889740348126 4.18297883812051e-24 NA NA NA hsa-miR-96-5p ACVR2A 3.24596558166606 1.92296159041707e-98 -0.964184609321378 1.30052843588401e-37 TargetScan;miRNATAP -0.154150910111768 2.30970117244934e-24 NA NA NA hsa-miR-141-5p ACVRL1 2.38411349683216 4.56310582620282e-58 -0.994521371753548 9.43795318776862e-31 MirTarget -0.286080031530524 1.69952548538369e-57 NA NA NA hsa-miR-182-5p ACVRL1 2.36408084103818 2.60011457600281e-72 -0.994521371753548 9.43795318776862e-31 mirMAP -0.267050964599793 2.09115786733005e-39 NA NA NA hsa-miR-429 ACVRL1 2.84108892259147 3.88520896426515e-64 -0.994521371753548 9.43795318776862e-31 miRNATAP -0.217758723954369 1.32424502294188e-41 NA NA NA hsa-miR-139-5p ADAM12 -3.25846663863766 2.62018989415003e-112 1.30450214121638 3.98075183367988e-15 miRanda -0.188322089006 5.05472723158868e-08 NA NA NA hsa-miR-145-5p ADAM19 -2.62703571936687 7.64402900188551e-88 1.59762293716606 1.34099246856257e-33 MirTarget;miRNATAP -0.150066364021448 2.52510427961121e-06 26823772 MiR 145 suppressed human retinoblastoma cell proliferation and invasion by targeting ADAM19; ADAM19 was identified as a direct target of miR-145; In addition a reverse correlation between miR-145 and ADAM19 expression was noted in RB tissues retinoblastoma hsa-miR-335-5p ADAM19 -2.61355235628987 2.6462884165886e-51 1.59762293716606 1.34099246856257e-33 MirTarget -0.196225123877446 7.13064195692024e-15 NA NA NA hsa-miR-141-3p ADAM22 2.99777540204168 1.26370498493024e-78 -1.22400577928345 9.86358971049703e-10 MirTarget -0.325602841119381 3.36084407370533e-17 NA NA NA hsa-miR-182-5p ADAM22 2.36408084103818 2.60011457600281e-72 -1.22400577928345 9.86358971049703e-10 MirTarget;miRNATAP -0.200617701901081 3.01172881141944e-05 NA NA NA hsa-miR-200a-3p ADAM22 2.55218480823434 2.96135446816238e-51 -1.22400577928345 9.86358971049703e-10 MirTarget -0.323271972498928 1.35746751762615e-17 NA NA NA hsa-miR-96-5p ADAM22 3.24596558166606 1.92296159041707e-98 -1.22400577928345 9.86358971049703e-10 TargetScan;miRNATAP -0.273314251423602 4.76028936646484e-12 NA NA NA hsa-miR-429 ADAM23 2.84108892259147 3.88520896426515e-64 -0.632718760993892 0.000906921335877247 miRanda -0.309740378711076 2.61703977417371e-18 NA NA NA hsa-miR-96-5p ADAM23 3.24596558166606 1.92296159041707e-98 -0.632718760993892 0.000906921335877247 TargetScan -0.307063834233471 1.34491774960471e-16 NA NA NA hsa-miR-335-5p ADAM8 -2.61355235628987 2.6462884165886e-51 2.44189334609262 3.00436525308675e-58 miRNAWalker2_validate -0.386921264180493 5.91707469042191e-41 NA NA NA hsa-miR-335-5p ADAMDEC1 -2.61355235628987 2.6462884165886e-51 3.13050236580306 5.97493610360938e-29 MirTarget -0.38897681034361 2.81593794651881e-13 NA NA NA hsa-miR-429 ADAMTS1 2.84108892259147 3.88520896426515e-64 -2.52466992473506 3.34298372105112e-57 miRanda -0.364283422550543 8.79920715373015e-32 NA NA NA hsa-miR-429 ADAMTS10 2.84108892259147 3.88520896426515e-64 -0.343180773589481 0.0127248286527458 miRNATAP -0.153129445741376 3.39713168309872e-09 NA NA NA hsa-miR-200b-3p ADAMTS12 2.11744072703209 1.66710572104191e-43 0.095778097632242 0.620632223066072 mirMAP -0.264667258652387 7.10484765340681e-11 NA NA NA hsa-miR-429 ADAMTS16 2.84108892259147 3.88520896426515e-64 -0.277733684404029 0.295058463295138 miRanda;miRNATAP -0.279595886551309 2.07682374250656e-08 NA NA NA hsa-miR-182-5p ADAMTS18 2.36408084103818 2.60011457600281e-72 -2.90477120379348 1.3334381798285e-29 miRNATAP -0.501485777639037 1.02397339825087e-15 NA NA NA hsa-miR-429 ADAMTS18 2.84108892259147 3.88520896426515e-64 -2.90477120379348 1.3334381798285e-29 miRanda;miRNATAP -0.426758250742541 7.00711767719002e-18 NA NA NA hsa-miR-96-5p ADAMTS18 3.24596558166606 1.92296159041707e-98 -2.90477120379348 1.3334381798285e-29 TargetScan;miRNATAP -0.51812732472099 5.43624197938448e-24 NA NA NA hsa-miR-429 ADAMTS2 2.84108892259147 3.88520896426515e-64 -0.221073363602919 0.172799998721038 miRNATAP -0.226886438320217 6.65438156312136e-14 NA NA NA hsa-miR-200b-3p ADAMTS3 2.11744072703209 1.66710572104191e-43 -1.84542990234679 6.7161576251528e-32 TargetScan -0.357854787678135 1.65460196696587e-26 NA NA NA hsa-miR-200c-3p ADAMTS3 2.07038651806183 6.84613386286599e-51 -1.84542990234679 6.7161576251528e-32 miRNATAP -0.378913133197869 1.40447480810563e-24 NA NA NA hsa-miR-375 ADAMTS3 2.09893673049766 1.68351780396203e-16 -1.84542990234679 6.7161576251528e-32 miRanda -0.211377302072856 6.27565684140763e-24 NA NA NA hsa-miR-429 ADAMTS3 2.84108892259147 3.88520896426515e-64 -1.84542990234679 6.7161576251528e-32 PITA;miRanda;miRNATAP -0.304707536176268 4.16574406398059e-24 NA NA NA hsa-miR-200b-3p ADAMTS5 2.11744072703209 1.66710572104191e-43 -3.55145538959317 1.2022506062627e-103 mirMAP -0.536814433225817 1.92001467155117e-46 NA NA NA hsa-miR-139-5p ADAMTS6 -3.25846663863766 2.62018989415003e-112 1.10058301750212 2.21011245527404e-16 miRanda -0.152676087938483 4.62694119579792e-08 NA NA NA hsa-miR-429 ADAMTS9 2.84108892259147 3.88520896426515e-64 -1.55322620968072 9.63042390631719e-33 PITA;miRanda -0.270261864106165 1.81326552124636e-27 NA NA NA hsa-miR-141-3p ADARB1 2.99777540204168 1.26370498493024e-78 -0.595462613403038 1.3979457164121e-17 MirTarget -0.12740702253446 3.6563894379826e-21 NA NA NA hsa-miR-200a-3p ADARB1 2.55218480823434 2.96135446816238e-51 -0.595462613403038 1.3979457164121e-17 MirTarget -0.113567939072377 1.36497140977077e-17 NA NA NA hsa-miR-375 ADAT2 2.09893673049766 1.68351780396203e-16 -0.644165701789122 3.106717959221e-12 miRNATAP -0.130241232642944 1.11111880501737e-27 NA NA NA hsa-miR-21-3p ADCY1 2.17476065946878 5.15299442583591e-75 -0.0486801025784516 0.841490665662841 mirMAP -0.160258692693419 0.0123733019596419 NA NA NA hsa-miR-378a-5p ADCY1 -2.43173551693523 1.44932837789175e-68 -0.0486801025784516 0.841490665662841 mirMAP -0.46013708741766 1.6733913629164e-17 NA NA NA hsa-miR-182-5p ADCY2 2.36408084103818 2.60011457600281e-72 -0.730984831999796 0.00385028718944911 miRNATAP -0.281958656910716 2.74086007176959e-06 NA NA NA hsa-miR-200b-3p ADCY2 2.11744072703209 1.66710572104191e-43 -0.730984831999796 0.00385028718944911 MirTarget;TargetScan -0.158301628874175 0.00321935577020458 NA NA NA hsa-miR-200c-3p ADCY2 2.07038651806183 6.84613386286599e-51 -0.730984831999796 0.00385028718944911 MirTarget;miRNATAP -0.244459398144202 3.36053103479726e-05 NA NA NA hsa-miR-429 ADCY2 2.84108892259147 3.88520896426515e-64 -0.730984831999796 0.00385028718944911 MirTarget;PITA;miRanda;miRNATAP -0.179953901437316 0.000172419368007167 NA NA NA hsa-miR-375 ADCY3 2.09893673049766 1.68351780396203e-16 -0.577026712399736 7.2058708663603e-13 miRanda -0.121210754435367 1.08407257088921e-31 NA NA NA hsa-miR-429 ADCY5 2.84108892259147 3.88520896426515e-64 -2.97150291708162 4.54793328372747e-24 miRNATAP -0.487979954385957 3.61607947851448e-18 NA NA NA hsa-miR-21-3p ADCY6 2.17476065946878 5.15299442583591e-75 -0.631200513666625 6.14065292828624e-14 mirMAP -0.223746818555908 1.22949628542935e-24 NA NA NA hsa-miR-429 ADCYAP1 2.84108892259147 3.88520896426515e-64 -0.668464336607076 0.0216193759187152 miRanda -0.183800024988956 0.00085509656078795 NA NA NA hsa-miR-429 ADCYAP1R1 2.84108892259147 3.88520896426515e-64 -4.2713481527338 3.34773162989707e-68 miRNATAP -0.703178628957535 1.85537936396534e-49 NA NA NA hsa-miR-200a-5p ADD2 2.58844508672328 1.79650654234569e-56 -1.02075625299636 3.28156866986006e-08 mirMAP -0.114495940545831 0.00163529137468866 NA NA NA hsa-miR-141-3p ADD3 2.99777540204168 1.26370498493024e-78 -1.65685209718137 2.45003179969732e-41 TargetScan -0.263212960545939 3.81687617104989e-27 NA NA NA hsa-miR-141-5p ADD3 2.38411349683216 4.56310582620282e-58 -1.65685209718137 2.45003179969732e-41 MirTarget -0.236036525914124 5.01822821220914e-18 NA NA NA hsa-miR-182-5p ADD3 2.36408084103818 2.60011457600281e-72 -1.65685209718137 2.45003179969732e-41 MirTarget;miRNATAP -0.306340953037683 1.81071989675609e-24 NA NA NA hsa-miR-200b-3p ADD3 2.11744072703209 1.66710572104191e-43 -1.65685209718137 2.45003179969732e-41 MirTarget;TargetScan -0.266738935573403 2.02311152238729e-23 NA NA NA hsa-miR-200c-3p ADD3 2.07038651806183 6.84613386286599e-51 -1.65685209718137 2.45003179969732e-41 MirTarget -0.256701147005047 4.49797313975644e-18 NA NA NA hsa-miR-429 ADD3 2.84108892259147 3.88520896426515e-64 -1.65685209718137 2.45003179969732e-41 MirTarget;PITA;miRanda;miRNATAP -0.254642690009979 9.35500810892699e-27 NA NA NA hsa-miR-96-5p ADD3 3.24596558166606 1.92296159041707e-98 -1.65685209718137 2.45003179969732e-41 TargetScan;miRNATAP -0.297861042058917 9.27720369666456e-34 NA NA NA hsa-miR-429 ADH1B 2.84108892259147 3.88520896426515e-64 -7.23318494086375 8.85226630409144e-51 miRanda -1.0781625753393 1.9622994082779e-30 NA NA NA hsa-miR-21-3p ADIPOQ 2.17476065946878 5.15299442583591e-75 -7.20325851283244 9.76136333708247e-50 MirTarget -1.38020281848918 1.67306281314213e-25 NA NA NA hsa-miR-429 ADIPOQ 2.84108892259147 3.88520896426515e-64 -7.20325851283244 9.76136333708247e-50 miRanda -1.05631389311478 7.03943458075418e-29 NA NA NA hsa-miR-145-5p ADM2 -2.62703571936687 7.64402900188551e-88 2.40773160906737 2.14684505542733e-54 mirMAP -0.434764452239048 1.22178026224893e-31 NA NA NA hsa-miR-429 ADRA2A 2.84108892259147 3.88520896426515e-64 -1.756794360729 1.51297877877696e-21 miRNATAP -0.352882170502367 4.07747349524561e-24 NA NA NA hsa-miR-429 ADRA2C 2.84108892259147 3.88520896426515e-64 -0.714048555963294 0.00160748726379395 miRanda -0.197915442502827 3.76349838694045e-06 NA NA NA hsa-miR-96-5p ADRA2C 3.24596558166606 1.92296159041707e-98 -0.714048555963294 0.00160748726379395 TargetScan -0.114953682657528 0.0104143762027795 NA NA NA hsa-miR-141-3p ADRB1 2.99777540204168 1.26370498493024e-78 -2.83309870348525 5.19354788418045e-26 TargetScan -0.472920237063766 3.18772778571292e-19 NA NA NA hsa-miR-486-5p ADSS -3.87258704301474 1.22658629378451e-80 0.806713563247381 1.38813192565443e-31 miRanda -0.118523935338964 1.64121643803629e-29 NA NA NA hsa-miR-10b-5p AEN -2.10996264627796 7.36811595736367e-72 0.495827505084496 3.95714262387593e-14 mirMAP -0.14716054819896 2.6198323422333e-17 NA NA NA hsa-miR-141-3p AFF1 2.99777540204168 1.26370498493024e-78 -0.822613403095266 3.54527732954134e-21 TargetScan -0.167728319342324 3.09578103922853e-23 NA NA NA hsa-miR-200b-3p AFF1 2.11744072703209 1.66710572104191e-43 -0.822613403095266 3.54527732954134e-21 TargetScan -0.146711896562333 3.4043465732044e-15 NA NA NA hsa-miR-429 AFF1 2.84108892259147 3.88520896426515e-64 -0.822613403095266 3.54527732954134e-21 PITA;miRanda;miRNATAP -0.154202735349008 9.85499913241732e-21 NA NA NA hsa-miR-141-5p AFF2 2.38411349683216 4.56310582620282e-58 -1.77942132767396 7.49943468170474e-23 mirMAP -0.41710267923256 4.0406800250559e-27 NA NA NA hsa-miR-182-5p AFF2 2.36408084103818 2.60011457600281e-72 -1.77942132767396 7.49943468170474e-23 mirMAP -0.414167939946839 9.30574151915069e-22 NA NA NA hsa-miR-21-3p AFF2 2.17476065946878 5.15299442583591e-75 -1.77942132767396 7.49943468170474e-23 mirMAP -0.258283273295784 1.09398623364586e-07 NA NA NA hsa-miR-429 AFF2 2.84108892259147 3.88520896426515e-64 -1.77942132767396 7.49943468170474e-23 miRNATAP -0.388444118574824 2.74460612767032e-30 NA NA NA hsa-miR-224-5p AFF3 -2.22249420723892 1.07787949391113e-18 -0.327024914278863 0.25539715780524 MirTarget -0.489480339393867 2.56887683469959e-41 NA NA NA hsa-miR-429 AFF3 2.84108892259147 3.88520896426515e-64 -0.327024914278863 0.25539715780524 MirTarget;PITA;miRanda;miRNATAP -0.12982561475669 0.0171879113207158 NA NA NA hsa-miR-224-5p AGBL4 -2.22249420723892 1.07787949391113e-18 -0.142971148431008 0.45128658353738 mirMAP -0.198611630941492 1.20975038620724e-15 NA NA NA hsa-miR-139-5p AGMAT -3.25846663863766 2.62018989415003e-112 1.48756865195736 3.00482085953982e-31 miRanda -0.28428677827331 8.3686674365955e-27 NA NA NA hsa-miR-200a-3p AGPAT4 2.55218480823434 2.96135446816238e-51 -0.74402848976969 1.61331655609006e-10 mirMAP -0.178524297114093 5.75801202016347e-16 NA NA NA hsa-miR-429 AGPAT4 2.84108892259147 3.88520896426515e-64 -0.74402848976969 1.61331655609006e-10 miRNATAP -0.138267036008631 3.76053353666005e-10 NA NA NA hsa-miR-200b-3p AHNAK 2.11744072703209 1.66710572104191e-43 -1.76535987346934 5.20116033627817e-56 TargetScan -0.263885490205761 1.22369803090683e-26 NA NA NA hsa-miR-429 AHNAK 2.84108892259147 3.88520896426515e-64 -1.76535987346934 5.20116033627817e-56 PITA;miRanda;miRNATAP -0.298865549263713 1.17970702350635e-43 NA NA NA hsa-miR-141-3p AHR 2.99777540204168 1.26370498493024e-78 -0.980545120708858 4.33733784004484e-18 MirTarget -0.159395599815798 6.33120628570809e-13 NA NA NA hsa-miR-182-5p AHR 2.36408084103818 2.60011457600281e-72 -0.980545120708858 4.33733784004484e-18 miRNATAP -0.174655605245195 1.45776972345333e-10 NA NA NA hsa-miR-200a-3p AHR 2.55218480823434 2.96135446816238e-51 -0.980545120708858 4.33733784004484e-18 MirTarget -0.124621123477467 1.19874035196394e-08 NA NA NA hsa-miR-429 AHR 2.84108892259147 3.88520896426515e-64 -0.980545120708858 4.33733784004484e-18 miRanda -0.13229580054063 1.05446750962943e-09 NA NA NA hsa-miR-96-5p AHR 3.24596558166606 1.92296159041707e-98 -0.980545120708858 4.33733784004484e-18 MirTarget;TargetScan;miRNATAP -0.201453277797448 1.956644511671e-19 NA NA NA hsa-miR-141-5p AIF1L 2.38411349683216 4.56310582620282e-58 -1.64811314998211 1.68248870295387e-22 MirTarget -0.105333003269014 0.00470207121377658 NA NA NA hsa-miR-145-5p AIFM1 -2.62703571936687 7.64402900188551e-88 0.674161514281666 1.79345695695194e-25 miRNATAP -0.134460530608588 6.48751185465965e-19 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-335-5p AIM1L -2.61355235628987 2.6462884165886e-51 3.885055088083 1.02172815426694e-58 miRNAWalker2_validate -0.486811333800849 2.05636048201332e-25 NA NA NA hsa-miR-183-5p AJAP1 2.95681814393872 1.09965777344285e-92 -0.989293299557779 2.83427988598234e-09 MirTarget -0.216461997174124 7.09110081274474e-10 NA NA NA hsa-miR-96-5p AJAP1 3.24596558166606 1.92296159041707e-98 -0.989293299557779 2.83427988598234e-09 MirTarget;TargetScan -0.158467069351109 1.67930674553906e-06 NA NA NA hsa-miR-96-5p AK3 3.24596558166606 1.92296159041707e-98 -0.932751435603142 6.6847406780176e-45 MirTarget;TargetScan -0.122317067960641 1.84222044617082e-19 NA NA NA hsa-miR-182-5p AK5 2.36408084103818 2.60011457600281e-72 -3.09055068172254 1.01327354138489e-28 MirTarget -0.404434487018494 2.82585238308227e-09 NA NA NA hsa-miR-141-3p AKAP11 2.99777540204168 1.26370498493024e-78 -0.849803143270922 1.35049720212879e-21 MirTarget;TargetScan -0.144425538403945 1.16186013193176e-16 NA NA NA hsa-miR-200a-3p AKAP11 2.55218480823434 2.96135446816238e-51 -0.849803143270922 1.35049720212879e-21 MirTarget -0.127992419305463 8.85216219295759e-14 NA NA NA hsa-miR-21-3p AKAP11 2.17476065946878 5.15299442583591e-75 -0.849803143270922 1.35049720212879e-21 MirTarget -0.137107175871711 8.985636583887e-09 NA NA NA hsa-miR-429 AKAP11 2.84108892259147 3.88520896426515e-64 -0.849803143270922 1.35049720212879e-21 miRanda;miRNATAP -0.149594449229351 1.01885418260479e-18 NA NA NA hsa-miR-183-5p AKAP12 2.95681814393872 1.09965777344285e-92 -2.7612699271992 1.19711805932247e-64 miRNAWalker2_validate;miRTarBase -0.537020940183852 1.04961055841343e-53 NA NA NA hsa-miR-200b-3p AKAP13 2.11744072703209 1.66710572104191e-43 -0.608726058300724 5.65488571630791e-18 mirMAP -0.120344712015622 9.74069500904e-16 NA NA NA hsa-miR-429 AKAP13 2.84108892259147 3.88520896426515e-64 -0.608726058300724 5.65488571630791e-18 miRNATAP -0.11424435773875 1.14260754930912e-17 NA NA NA hsa-miR-141-3p AKAP2 2.99777540204168 1.26370498493024e-78 -2.13773125985336 8.00531395229553e-27 TargetScan -0.428215598358269 2.06620881154245e-28 NA NA NA hsa-miR-200a-5p AKAP2 2.58844508672328 1.79650654234569e-56 -2.13773125985336 8.00531395229553e-27 mirMAP -0.28467461327721 7.72627126358166e-13 NA NA NA hsa-miR-200b-3p AKAP2 2.11744072703209 1.66710572104191e-43 -2.13773125985336 8.00531395229553e-27 TargetScan -0.405091591317364 2.18933410621375e-21 NA NA NA hsa-miR-429 AKAP2 2.84108892259147 3.88520896426515e-64 -2.13773125985336 8.00531395229553e-27 PITA;miRanda;miRNATAP -0.359593064996128 3.86216291296785e-21 NA NA NA hsa-miR-21-5p AKAP6 2.32007501846389 3.08394781855554e-137 -2.28015270926059 6.96245937007291e-60 MirTarget -0.608209651033571 2.41703851935952e-42 NA NA NA hsa-miR-375 AKAP6 2.09893673049766 1.68351780396203e-16 -2.28015270926059 6.96245937007291e-60 miRanda -0.113850093049129 7.84133703308836e-09 NA NA NA hsa-miR-429 AKAP6 2.84108892259147 3.88520896426515e-64 -2.28015270926059 6.96245937007291e-60 miRanda -0.29687166234165 7.12364354737482e-27 NA NA NA hsa-miR-182-5p AKAP7 2.36408084103818 2.60011457600281e-72 -1.0178339192539 7.53705785799862e-33 miRNATAP -0.212849603704607 3.5164938254826e-25 NA NA NA hsa-miR-200c-3p AKAP7 2.07038651806183 6.84613386286599e-51 -1.0178339192539 7.53705785799862e-33 miRNATAP -0.190834063323771 3.5627421858081e-21 NA NA NA hsa-miR-375 AKAP7 2.09893673049766 1.68351780396203e-16 -1.0178339192539 7.53705785799862e-33 miRNAWalker2_validate;miRanda -0.110996980809323 2.22534687315583e-22 NA NA NA hsa-miR-429 AKAP7 2.84108892259147 3.88520896426515e-64 -1.0178339192539 7.53705785799862e-33 miRanda;miRNATAP -0.155035153861562 3.41824753852973e-21 NA NA NA hsa-miR-96-5p AKAP7 3.24596558166606 1.92296159041707e-98 -1.0178339192539 7.53705785799862e-33 miRNATAP -0.168394720063853 6.53056812884295e-23 NA NA NA hsa-miR-378a-5p AKAP8L -2.43173551693523 1.44932837789175e-68 0.65676179902206 3.47607176146108e-18 miRNAWalker2_validate -0.136784987660873 1.58995524939279e-15 NA NA NA hsa-miR-21-5p AKAP9 2.32007501846389 3.08394781855554e-137 -0.14825797051247 0.136977115319607 miRNAWalker2_validate -0.168978346657109 4.29479028294113e-08 NA NA NA hsa-miR-21-5p AKIRIN1 2.32007501846389 3.08394781855554e-137 -0.154993926519317 0.00875100530628838 miRNATAP -0.105340715301105 8.03937220548246e-09 NA NA NA hsa-miR-182-5p AKR1C1 2.36408084103818 2.60011457600281e-72 -4.35313922304112 2.54210048142747e-67 mirMAP -0.806632487481479 1.89191165151196e-38 NA NA NA hsa-miR-96-5p AKR1C1 3.24596558166606 1.92296159041707e-98 -4.35313922304112 2.54210048142747e-67 mirMAP -0.724032149575141 1.69175129295178e-45 NA NA NA hsa-miR-141-5p AKR1C2 2.38411349683216 4.56310582620282e-58 -4.63251656658313 7.3817769746438e-54 MirTarget -0.757116253107972 5.3037698827517e-30 NA NA NA hsa-miR-486-5p AKR7L -3.87258704301474 1.22658629378451e-80 1.2636602388458 1.67941415061242e-12 miRanda -0.101463495042763 0.000228202489919731 NA NA NA hsa-miR-511-5p ALCAM -2.27545475897362 3.84085514050558e-36 0.50501413295289 0.00106417407883302 MirTarget -0.116062334277638 3.57282159218251e-05 NA NA NA hsa-miR-429 ALDH1A1 2.84108892259147 3.88520896426515e-64 -2.87328046628465 2.38118890696821e-66 miRanda -0.496273668922194 1.30934887397647e-53 NA NA NA hsa-miR-429 ALDH1A3 2.84108892259147 3.88520896426515e-64 -2.22226246517506 2.31740130877876e-35 PITA;miRanda -0.223289622612546 2.01448356326398e-10 NA NA NA hsa-miR-429 ALDH1L2 2.84108892259147 3.88520896426515e-64 -0.0393531240213658 0.786156469224884 miRanda -0.124348823000833 5.43312651024783e-06 NA NA NA hsa-miR-139-5p ALDH3B2 -3.25846663863766 2.62018989415003e-112 1.1107706134136 6.25215153082012e-05 miRanda -0.129281250568711 0.024319611387424 NA NA NA hsa-miR-96-5p ALDH6A1 3.24596558166606 1.92296159041707e-98 -1.05979354788967 2.70938286396766e-19 TargetScan -0.115834024622927 1.07761147236269e-06 NA NA NA hsa-miR-139-5p ALG11 -3.25846663863766 2.62018989415003e-112 0.771993933730004 7.99286031140743e-15 miRanda -0.134279076994834 6.85211513916628e-11 NA NA NA hsa-miR-96-5p ALK 3.24596558166606 1.92296159041707e-98 -1.94766209778723 1.314997683111e-21 MirTarget;TargetScan;miRNATAP -0.358057953792612 1.0400059010039e-18 22414602 MicroRNA 96 is a post transcriptional suppressor of anaplastic lymphoma kinase expression; Three Internet-based algorithms identified miR-96 to potentially bind with the ALK 3'-untranslated region; Transfection of the cell lines with miR-96 decreased levels of the different forms of ALK protein without significant effects on ALK mRNA; These data provide novel evidence that decreases in miR-96 could represent a mechanism underlying the aberrant expression of ALK in cancer cells lymphoma hsa-miR-429 ALPK3 2.84108892259147 3.88520896426515e-64 -1.48346700629587 7.56655443821059e-36 miRNATAP -0.282860747205789 2.86921125286426e-36 NA NA NA hsa-miR-200a-5p ALX4 2.58844508672328 1.79650654234569e-56 -3.21510012414237 4.06971831531578e-34 miRNATAP -0.309662232456521 6.65000661990074e-09 NA NA NA hsa-miR-183-5p AMIGO2 2.95681814393872 1.09965777344285e-92 -1.57919489364877 1.03555350832452e-17 MirTarget -0.269077066993735 6.62955970919576e-12 NA NA NA hsa-miR-139-5p AMMECR1 -3.25846663863766 2.62018989415003e-112 0.820552955502696 5.79082960254587e-17 miRanda -0.195787929546302 1.59241873146332e-22 NA NA NA hsa-miR-224-5p AMN1 -2.22249420723892 1.07787949391113e-18 0.0474868702609683 0.575694759385197 MirTarget -0.111268441586752 3.05831977893753e-24 NA NA NA hsa-miR-21-3p AMOT 2.17476065946878 5.15299442583591e-75 -0.909511733140738 9.01707191016367e-13 mirMAP -0.107349017141088 0.0015715981594809 NA NA NA hsa-miR-141-3p AMOTL1 2.99777540204168 1.26370498493024e-78 -1.81201810992899 1.05521553005433e-44 TargetScan -0.360715714538228 5.88104675427885e-47 NA NA NA hsa-miR-182-5p AMOTL2 2.36408084103818 2.60011457600281e-72 -1.56594440622319 8.21783947483569e-62 miRNATAP -0.295510700970583 4.91947490294023e-37 NA NA NA hsa-miR-200b-3p AMOTL2 2.11744072703209 1.66710572104191e-43 -1.56594440622319 8.21783947483569e-62 MirTarget;TargetScan -0.197924100714029 7.66668807426866e-21 NA NA NA hsa-miR-200c-3p AMOTL2 2.07038651806183 6.84613386286599e-51 -1.56594440622319 8.21783947483569e-62 MirTarget;miRNATAP -0.28595633906363 3.76895161364983e-36 NA NA NA hsa-miR-429 AMOTL2 2.84108892259147 3.88520896426515e-64 -1.56594440622319 8.21783947483569e-62 MirTarget;PITA;miRanda;miRNATAP -0.205210399292388 4.96123571406442e-28 NA NA NA hsa-miR-96-5p AMOTL2 3.24596558166606 1.92296159041707e-98 -1.56594440622319 8.21783947483569e-62 TargetScan;miRNATAP -0.285372600368364 2.29650958650199e-51 NA NA NA hsa-miR-182-5p AMT 2.36408084103818 2.60011457600281e-72 -1.26692807174467 2.4916311221105e-18 MirTarget -0.181746334132222 2.2838418333037e-07 NA NA NA hsa-miR-224-5p AMZ1 -2.22249420723892 1.07787949391113e-18 2.49247827940287 4.85570356046494e-25 mirMAP -0.22949697878475 2.13832188108332e-12 NA NA NA hsa-miR-378a-5p AMZ1 -2.43173551693523 1.44932837789175e-68 2.49247827940287 4.85570356046494e-25 mirMAP -0.625134900168323 1.08600219593812e-30 NA NA NA hsa-miR-139-5p ANAPC7 -3.25846663863766 2.62018989415003e-112 0.550641679190882 1.29069564317652e-28 miRanda -0.123681144516392 2.20881098673168e-34 NA NA NA hsa-miR-429 ANGPT1 2.84108892259147 3.88520896426515e-64 -3.16300498545581 8.56501022163231e-73 miRanda -0.493163485450717 1.16635414095955e-46 NA NA NA hsa-miR-429 ANGPT2 2.84108892259147 3.88520896426515e-64 -0.549211576203072 3.52083224037155e-07 miRanda -0.156050420625197 1.27561726808804e-14 NA NA NA hsa-miR-141-3p ANGPTL1 2.99777540204168 1.26370498493024e-78 -3.72061004689091 3.17960434867383e-73 MirTarget -0.825151345507015 3.21808884767287e-101 NA NA NA hsa-miR-200a-3p ANGPTL1 2.55218480823434 2.96135446816238e-51 -3.72061004689091 3.17960434867383e-73 MirTarget -0.661548060367103 5.84581781860266e-62 NA NA NA hsa-miR-141-3p ANK2 2.99777540204168 1.26370498493024e-78 -2.50568252042295 2.12750718019692e-56 TargetScan;miRNATAP -0.568863103205172 7.63797154489955e-81 NA NA NA hsa-miR-182-5p ANK2 2.36408084103818 2.60011457600281e-72 -2.50568252042295 2.12750718019692e-56 miRNATAP -0.52129032448654 9.38499740766781e-42 NA NA NA hsa-miR-200a-3p ANK2 2.55218480823434 2.96135446816238e-51 -2.50568252042295 2.12750718019692e-56 miRNATAP -0.460747281221904 7.89543593463606e-52 NA NA NA hsa-miR-429 ANK2 2.84108892259147 3.88520896426515e-64 -2.50568252042295 2.12750718019692e-56 miRanda;miRNATAP -0.45668396725815 1.3454813040015e-51 NA NA NA hsa-miR-429 ANKDD1A 2.84108892259147 3.88520896426515e-64 -1.49754178019107 2.00336671474173e-58 miRanda -0.20468099422279 4.8807392623587e-29 NA NA NA hsa-miR-200b-3p ANKH 2.11744072703209 1.66710572104191e-43 -0.310260036945063 0.00327101824761011 TargetScan -0.126693737676158 1.22328119806009e-08 NA NA NA hsa-miR-200c-3p ANKH 2.07038651806183 6.84613386286599e-51 -0.310260036945063 0.00327101824761011 miRNATAP -0.156974091082588 1.23229484414772e-10 NA NA NA hsa-miR-429 ANKH 2.84108892259147 3.88520896426515e-64 -0.310260036945063 0.00327101824761011 PITA;miRanda;miRNATAP -0.103190878410254 2.13323255226908e-07 NA NA NA hsa-miR-139-5p ANKRD1 -3.25846663863766 2.62018989415003e-112 0.416713342766787 0.116748320391091 miRanda -0.274917653445745 4.36144762972389e-07 NA NA NA hsa-miR-375 ANKRD1 2.09893673049766 1.68351780396203e-16 0.416713342766787 0.116748320391091 miRNAWalker2_validate -0.122331634740557 0.00047330864375129 NA NA NA hsa-miR-139-5p ANKRD13D -3.25846663863766 2.62018989415003e-112 1.00908641280701 3.29090062211511e-28 miRanda -0.1313921370712 9.64310644266166e-12 NA NA NA hsa-miR-335-5p ANKRD22 -2.61355235628987 2.6462884165886e-51 2.16925131251558 8.7598003195142e-36 miRNAWalker2_validate -0.236879024486614 1.16969720186456e-12 NA NA NA hsa-miR-486-5p ANKRD22 -3.87258704301474 1.22658629378451e-80 2.16925131251558 8.7598003195142e-36 MirTarget;miRanda -0.299308918912099 2.96815535302671e-29 NA NA NA hsa-miR-429 ANKRD40 2.84108892259147 3.88520896426515e-64 -0.791245971243747 7.12134325357547e-25 miRanda -0.140741207843299 5.78548438791148e-22 NA NA NA hsa-miR-141-3p ANKRD44 2.99777540204168 1.26370498493024e-78 -0.721040566621111 3.92080009780825e-06 TargetScan -0.208148414083597 5.28742641506444e-12 NA NA NA hsa-miR-21-5p ANKRD46 2.32007501846389 3.08394781855554e-137 -0.464275837433727 5.25998680892498e-08 miRNAWalker2_validate;miRTarBase -0.309003306442088 3.15456465435422e-33 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC breast cancer hsa-miR-429 ANKRD6 2.84108892259147 3.88520896426515e-64 -0.783455899923391 5.79976147201525e-17 miRanda -0.146291981009605 1.72391296083098e-16 NA NA NA hsa-miR-21-5p ANKS1B 2.32007501846389 3.08394781855554e-137 0.195574172772792 0.219403504513109 MirTarget -0.121716593374487 0.0142128877072745 NA NA NA hsa-miR-452-5p ANKS1B -2.48486455572568 1.24430987974325e-33 0.195574172772792 0.219403504513109 miRNATAP -0.292490270164633 5.74850826027726e-33 NA NA NA hsa-miR-429 ANKS6 2.84108892259147 3.88520896426515e-64 -0.809651206056516 9.90850161913119e-08 miRNATAP -0.170038850118173 3.39971274841834e-09 NA NA NA hsa-miR-21-5p ANO3 2.32007501846389 3.08394781855554e-137 -3.64557417953708 1.01050480975905e-31 mirMAP -0.867081885789892 1.73647926570769e-18 NA NA NA hsa-miR-429 ANO3 2.84108892259147 3.88520896426515e-64 -3.64557417953708 1.01050480975905e-31 miRanda -0.525478521184144 2.16819992875345e-18 NA NA NA hsa-miR-375 ANO4 2.09893673049766 1.68351780396203e-16 -1.89180414865337 4.86866295228441e-20 miRanda -0.127318693799825 4.54211271122188e-06 NA NA NA hsa-miR-141-3p ANO5 2.99777540204168 1.26370498493024e-78 -1.98544340155599 8.34965716678519e-13 mirMAP -0.340657712632385 3.31467408994044e-10 NA NA NA hsa-miR-200a-3p ANO5 2.55218480823434 2.96135446816238e-51 -1.98544340155599 8.34965716678519e-13 mirMAP -0.311185295258454 5.18687155653097e-09 NA NA NA hsa-miR-200b-3p ANO5 2.11744072703209 1.66710572104191e-43 -1.98544340155599 8.34965716678519e-13 TargetScan -0.373263705818667 2.79179284186207e-10 NA NA NA hsa-miR-429 ANO5 2.84108892259147 3.88520896426515e-64 -1.98544340155599 8.34965716678519e-13 miRanda -0.375615114725752 9.75882838248806e-13 NA NA NA hsa-miR-141-3p ANO6 2.99777540204168 1.26370498493024e-78 -1.49912453977001 1.20172073520865e-64 MirTarget;TargetScan -0.281754150820712 9.20313817915817e-60 NA NA NA hsa-miR-182-5p ANO6 2.36408084103818 2.60011457600281e-72 -1.49912453977001 1.20172073520865e-64 miRNAWalker2_validate -0.21828559799745 9.42472301796553e-23 NA NA NA hsa-miR-200a-3p ANO6 2.55218480823434 2.96135446816238e-51 -1.49912453977001 1.20172073520865e-64 MirTarget -0.258005973885225 3.45014543233283e-51 NA NA NA hsa-miR-200b-3p ANO6 2.11744072703209 1.66710572104191e-43 -1.49912453977001 1.20172073520865e-64 TargetScan -0.284382409685243 3.53581782770677e-50 NA NA NA hsa-miR-429 ANO6 2.84108892259147 3.88520896426515e-64 -1.49912453977001 1.20172073520865e-64 miRanda -0.264547714121806 5.88915152385634e-55 NA NA NA hsa-miR-337-3p ANP32E -2.14274617598363 2.70942896809734e-43 0.402484586920244 0.000744192411374184 MirTarget;PITA;miRNATAP -0.111977363443423 6.99920906623302e-06 NA NA NA hsa-miR-96-5p ANPEP 3.24596558166606 1.92296159041707e-98 -1.77724581367248 2.49549372132156e-18 mirMAP -0.335327151231264 1.02022529938659e-16 NA NA NA hsa-miR-182-5p ANTXR2 2.36408084103818 2.60011457600281e-72 -1.70068413242488 4.05544931296497e-58 miRNATAP -0.396698239118996 2.77870398315655e-55 NA NA NA hsa-miR-429 ANTXR2 2.84108892259147 3.88520896426515e-64 -1.70068413242488 4.05544931296497e-58 miRNATAP -0.33345379104618 9.12631940311188e-63 NA NA NA hsa-miR-96-5p ANTXR2 3.24596558166606 1.92296159041707e-98 -1.70068413242488 4.05544931296497e-58 TargetScan;miRNATAP -0.375952441121012 3.26917788599994e-75 NA NA NA hsa-miR-21-5p ANXA1 2.32007501846389 3.08394781855554e-137 -2.51445900109999 2.46621218918931e-79 MirTarget -0.469016266891393 7.01388858801368e-26 NA NA NA hsa-miR-429 AOC2 2.84108892259147 3.88520896426515e-64 -2.35170633333852 1.26528926324737e-55 miRanda -0.317203538769816 5.10000522002201e-27 NA NA NA hsa-miR-486-5p AP1G2 -3.87258704301474 1.22658629378451e-80 0.931594536252005 6.30289263089716e-24 miRanda -0.114872824688815 5.66537848917019e-16 NA NA NA hsa-miR-139-5p AP1S1 -3.25846663863766 2.62018989415003e-112 1.3576180379378 9.96949472634498e-65 miRanda -0.231674653044241 1.29990562357281e-42 NA NA NA hsa-miR-141-5p AP1S2 2.38411349683216 4.56310582620282e-58 -0.496390996685573 3.28637648180757e-10 MirTarget -0.155221234285549 1.79744438143725e-20 NA NA NA hsa-miR-200b-3p AP1S2 2.11744072703209 1.66710572104191e-43 -0.496390996685573 3.28637648180757e-10 MirTarget;TargetScan -0.173857287456663 3.05104267622167e-26 NA NA NA hsa-miR-200c-3p AP1S2 2.07038651806183 6.84613386286599e-51 -0.496390996685573 3.28637648180757e-10 MirTarget;miRNATAP -0.195915746422791 1.44749928423614e-27 NA NA NA hsa-miR-429 AP1S2 2.84108892259147 3.88520896426515e-64 -0.496390996685573 3.28637648180757e-10 MirTarget;PITA;miRanda;miRNATAP -0.137307807510643 1.36282294517933e-20 NA NA NA hsa-miR-139-5p AP2M1 -3.25846663863766 2.62018989415003e-112 0.530747756960929 2.19546042003605e-21 miRanda -0.11252888264649 1.01490885526431e-22 NA NA NA hsa-miR-429 APBA1 2.84108892259147 3.88520896426515e-64 -1.66379573331028 2.46279779229371e-37 miRNATAP -0.178214566201449 3.01830786092787e-12 NA NA NA hsa-miR-182-5p APBA2 2.36408084103818 2.60011457600281e-72 0.634091733718519 0.000978666224229869 MirTarget -0.185232321970785 5.31037500111109e-05 NA NA NA hsa-miR-375 APBB1IP 2.09893673049766 1.68351780396203e-16 -1.18647316054575 4.02954740551006e-24 miRanda;miRNATAP -0.129151936868526 1.34300033454086e-16 NA NA NA hsa-miR-141-3p APBB2 2.99777540204168 1.26370498493024e-78 -0.387682647024633 0.000198063436440459 MirTarget;TargetScan -0.112170596783828 2.6642528251022e-08 NA NA NA hsa-miR-106b-5p APC 1.22477789913175 2.31787213143326e-32 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate;miRTarBase -0.313795610281918 3.20314695735614e-32 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-107 APC 0.678998026350662 2.56224148930538e-16 -0.686703117134189 5.76715056853234e-16 miRanda -0.266050961631061 1.99405735689927e-14 NA NA NA hsa-miR-155-5p APC 1.09766314984151 4.55650930885814e-15 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate;miRTarBase;miRNATAP -0.154771290746743 4.27853241366662e-14 23796566 Upregulated miR 155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/β catenin signaling; We have searched for miR-155 targets and identified the hypothesis that miR-155 could promote tumor growth of PTC by targeted regulation of adenomatous polyposis coli APC expression and activating the Wnt/β-catenin signaling; Further studies revealed that APC is a novel miR-155 target because miR-155 bound directly to its 3'-untranslated region and reduced both the mRNA and protein levels of APC; Similar to the miR-155 over-expression APC downregulation promoted cell growth whereas rescued APC expression reversed the promotive effect of miR-155; By targeting APC miR-155 efficiently regulates the Wnt/β-catenin signaling thyroid cancer hsa-miR-21-5p APC 2.32007501846389 3.08394781855554e-137 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate -0.246283784759972 7.23712061544539e-21 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-27a-3p APC 0.388496361379095 1.42373532086331e-05 -0.686703117134189 5.76715056853234e-16 miRNAWalker2_validate;miRTarBase;miRNATAP -0.178295160206353 5.95535983433013e-08 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-374a-5p APC -0.239709888246804 0.00309819667153627 -0.686703117134189 5.76715056853234e-16 mirMAP -0.183579142691311 5.11997182923449e-07 NA NA NA hsa-miR-590-3p APC 1.27438512890514 1.03164723481469e-23 -0.686703117134189 5.76715056853234e-16 PITA;miRanda;mirMAP;miRNATAP -0.118033171177274 5.72074719287459e-07 NA NA NA hsa-miR-125a-5p APC2 -0.635694700253268 3.6703235721638e-11 0.94072973482498 4.47395383461655e-10 mirMAP -0.15416857175893 0.00430379284665603 NA NA NA hsa-miR-125b-5p APC2 -1.94393269763542 2.78180543229264e-58 0.94072973482498 4.47395383461655e-10 mirMAP -0.2419595151452 1.3692162649798e-09 NA NA NA hsa-miR-20a-3p APC2 -0.218902047543766 0.179868363625547 0.94072973482498 4.47395383461655e-10 mirMAP -0.138852827654145 1.45583029063542e-05 NA NA NA hsa-miR-2355-5p APC2 -0.221733044425126 0.0231054202524677 0.94072973482498 4.47395383461655e-10 mirMAP -0.186684220875449 0.000506491734344051 NA NA NA hsa-miR-28-5p APC2 -0.14267073663385 0.0497619246260571 0.94072973482498 4.47395383461655e-10 mirMAP -0.274501081998138 0.000152045555835454 NA NA NA hsa-miR-345-5p APC2 0.639728356429512 0.00013070715719672 0.94072973482498 4.47395383461655e-10 mirMAP -0.110916549318979 0.000360181957971393 NA NA NA hsa-miR-505-5p APC2 -0.842640534241897 4.43022473091907e-09 0.94072973482498 4.47395383461655e-10 mirMAP -0.173610865295371 1.44750832015884e-06 NA NA NA hsa-miR-429 APCDD1L 2.84108892259147 3.88520896426515e-64 -2.61333360251574 1.02924166385575e-31 miRNATAP -0.223323831150392 3.21769510703437e-07 NA NA NA hsa-miR-139-5p APH1A -3.25846663863766 2.62018989415003e-112 0.880951296770373 4.04327073394667e-49 miRanda -0.160761109656267 5.69720560737982e-38 NA NA NA hsa-miR-145-5p APH1A -2.62703571936687 7.64402900188551e-88 0.880951296770373 4.04327073394667e-49 miRNAWalker2_validate -0.175822049334125 1.47914936534563e-35 NA NA NA hsa-miR-21-5p APH1B 2.32007501846389 3.08394781855554e-137 -0.54479585718112 9.6615433048135e-08 MirTarget -0.290927209259053 1.62431064353651e-20 NA NA NA hsa-miR-375 APLF 2.09893673049766 1.68351780396203e-16 -0.950239740782094 1.61527175884475e-17 miRanda -0.15495698605645 1.78965177639779e-26 NA NA NA hsa-miR-335-5p APLN -2.61355235628987 2.6462884165886e-51 0.0440734753395802 0.757862873205502 miRNATAP -0.102872454487117 0.000102192170077186 NA NA NA hsa-miR-335-5p APLP1 -2.61355235628987 2.6462884165886e-51 1.5236861073529 2.43885608522215e-12 miRNAWalker2_validate -0.197030082438244 1.34770900138626e-06 NA NA NA hsa-miR-375 APOB 2.09893673049766 1.68351780396203e-16 -5.95582623532149 2.97231616769097e-92 miRanda -0.285489398654386 2.7787345974269e-11 NA NA NA hsa-miR-335-5p APOC1 -2.61355235628987 2.6462884165886e-51 1.20419199697162 8.90130669305456e-16 miRNAWalker2_validate -0.134803360808411 1.75455121981852e-06 NA NA NA hsa-miR-141-3p APOLD1 2.99777540204168 1.26370498493024e-78 -1.79825454034465 2.31789749575749e-44 TargetScan -0.327410781495122 1.77912119261345e-38 NA NA NA hsa-miR-21-5p APOLD1 2.32007501846389 3.08394781855554e-137 -1.79825454034465 2.31789749575749e-44 miRNAWalker2_validate -0.520450883320982 8.90831889443895e-38 NA NA NA hsa-miR-21-5p APPL1 2.32007501846389 3.08394781855554e-137 -0.293727326519519 8.82214003895385e-06 miRNAWalker2_validate -0.195099261510173 3.55854063868429e-22 NA NA NA hsa-miR-141-3p AQP4 2.99777540204168 1.26370498493024e-78 -2.94944371494166 1.54083437012241e-32 mirMAP -0.251865826920113 4.72861914987748e-07 NA NA NA hsa-miR-200a-3p AQP4 2.55218480823434 2.96135446816238e-51 -2.94944371494166 1.54083437012241e-32 mirMAP -0.197355364504465 6.02262825014054e-05 NA NA NA hsa-miR-200b-3p AQP4 2.11744072703209 1.66710572104191e-43 -2.94944371494166 1.54083437012241e-32 mirMAP -0.154791287067836 0.00476687585768176 NA NA NA hsa-miR-200c-3p AQP4 2.07038651806183 6.84613386286599e-51 -2.94944371494166 1.54083437012241e-32 mirMAP -0.155670616049212 0.00987400760488715 NA NA NA hsa-miR-375 AQP4 2.09893673049766 1.68351780396203e-16 -2.94944371494166 1.54083437012241e-32 miRanda -0.168807277393739 6.53176799420112e-07 NA NA NA hsa-miR-429 AQP4 2.84108892259147 3.88520896426515e-64 -2.94944371494166 1.54083437012241e-32 miRanda;mirMAP -0.235800132481048 1.3198551624293e-06 NA NA NA hsa-miR-141-3p AR 2.99777540204168 1.26370498493024e-78 -0.998221110404377 0.000935519021681841 mirMAP -0.282854868987828 1.34431712973354e-06 26062412;22314666 miR 141 3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells; After prostate cancer cell line LNCaP was transfected with miR-141-3p mimics expression levels of AR mRNA and protein in the LNCaP cells were detected by reverse transcription PCR and Western blotting respectively; The 3'untranslated regions 3'UTR of AR mRNA containing the binding site of miR-141-3p was amplified by PCR and inserted into pmiR-report vector a 3'downstream luciferase reporter gene; Transfection of miR-141-3p mimics decreased both mRNA and protein expression levels of AR in LNCaP cells; AR is a direct target gene of miR-141-3p;miR 141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein; Here we investigated the correlation of Shp expression with the cellular level of miR-141 and its effects on AR transcriptional activity in non-malignant and malignant human prostate epithelial cell lines; Phenethyl isothiocyanate a natural constituent of many edible cruciferous vegetables increased Shp expression downregulated miR-141 and inhibited AR transcriptional activity in LNCaP cells; Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141 which promotes AR transcriptional activity ;malignant trasformation prostate cancer;prostate cancer hsa-miR-200a-3p AR 2.55218480823434 2.96135446816238e-51 -0.998221110404377 0.000935519021681841 mirMAP -0.294399228290278 2.87045055692448e-07 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-200a-5p AR 2.58844508672328 1.79650654234569e-56 -0.998221110404377 0.000935519021681841 miRNATAP -0.128542329618057 0.0296939091922574 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-429 AR 2.84108892259147 3.88520896426515e-64 -0.998221110404377 0.000935519021681841 miRNATAP -0.352561887119055 5.29542535793022e-10 NA NA NA hsa-miR-10b-5p ARFGAP1 -2.10996264627796 7.36811595736367e-72 1.21598070827383 1.00785381822634e-43 mirMAP -0.287835835624514 5.41122226985896e-34 NA NA NA hsa-miR-429 ARHGAP10 2.84108892259147 3.88520896426515e-64 -1.53458852202645 1.76827427388182e-40 miRanda -0.270650824091904 9.3461588576372e-35 NA NA NA hsa-miR-144-5p ARHGAP11A -2.75914786146772 1.55794225315972e-50 1.93370632699492 5.94321783489522e-44 MirTarget -0.157667715440864 5.13471503526289e-10 NA NA NA hsa-miR-429 ARHGAP15 2.84108892259147 3.88520896426515e-64 -0.0304824515280424 0.811459505746828 miRanda -0.10193019441223 2.35491653917936e-05 NA NA NA hsa-miR-96-5p ARHGAP19 3.24596558166606 1.92296159041707e-98 -0.973447425093666 1.02955194197712e-41 MirTarget -0.145288091384427 2.01459457599423e-23 NA NA NA hsa-miR-200b-3p ARHGAP20 2.11744072703209 1.66710572104191e-43 -3.512662334718 2.09645994175907e-93 MirTarget;TargetScan -0.587855218928282 3.60262846554934e-53 NA NA NA hsa-miR-200c-3p ARHGAP20 2.07038651806183 6.84613386286599e-51 -3.512662334718 2.09645994175907e-93 MirTarget;miRNATAP -0.692917700977352 3.25337232704824e-62 NA NA NA hsa-miR-429 ARHGAP20 2.84108892259147 3.88520896426515e-64 -3.512662334718 2.09645994175907e-93 MirTarget;miRanda;miRNATAP -0.575614835420394 1.44768515073251e-65 NA NA NA hsa-miR-183-5p ARHGAP21 2.95681814393872 1.09965777344285e-92 -1.04619684110333 6.372378546429e-32 miRNAWalker2_validate;MirTarget;miRNATAP -0.150359773388753 4.57310043592299e-15 NA NA NA hsa-miR-21-5p ARHGAP21 2.32007501846389 3.08394781855554e-137 -1.04619684110333 6.372378546429e-32 miRNAWalker2_validate -0.30028897524233 5.81102696469372e-27 NA NA NA hsa-miR-429 ARHGAP21 2.84108892259147 3.88520896426515e-64 -1.04619684110333 6.372378546429e-32 miRanda;miRNATAP -0.131930934905828 2.08689187445524e-14 NA NA NA hsa-miR-141-3p ARHGAP23 2.99777540204168 1.26370498493024e-78 -0.925868681835253 5.11227832106067e-21 TargetScan -0.234505123259787 8.62418151253771e-36 NA NA NA hsa-miR-141-3p ARHGAP24 2.99777540204168 1.26370498493024e-78 -1.40822309796801 1.02598155255413e-44 TargetScan;miRNATAP -0.32825443350451 4.46501183385659e-67 NA NA NA hsa-miR-200a-3p ARHGAP24 2.55218480823434 2.96135446816238e-51 -1.40822309796801 1.02598155255413e-44 miRNATAP -0.281391263081028 2.01960634538128e-49 NA NA NA hsa-miR-21-5p ARHGAP24 2.32007501846389 3.08394781855554e-137 -1.40822309796801 1.02598155255413e-44 MirTarget;miRNATAP -0.312948652354249 2.89377453720354e-22 NA NA NA hsa-miR-429 ARHGAP24 2.84108892259147 3.88520896426515e-64 -1.40822309796801 1.02598155255413e-44 miRanda;miRNATAP -0.266933415759468 1.03557990526217e-44 NA NA NA hsa-miR-96-5p ARHGAP24 3.24596558166606 1.92296159041707e-98 -1.40822309796801 1.02598155255413e-44 MirTarget;TargetScan;miRNATAP -0.288028321234284 4.65171204110568e-48 NA NA NA hsa-miR-429 ARHGAP25 2.84108892259147 3.88520896426515e-64 -0.62651813585556 5.81063123797991e-09 miRNATAP -0.136103439009017 2.19569431839707e-11 NA NA NA hsa-miR-183-5p ARHGAP26 2.95681814393872 1.09965777344285e-92 -1.50827592959053 4.39412178107472e-38 MirTarget -0.261087323073097 2.20861037740945e-25 NA NA NA hsa-miR-200a-5p ARHGAP26 2.58844508672328 1.79650654234569e-56 -1.50827592959053 4.39412178107472e-38 mirMAP -0.157604738357858 2.81415472496369e-11 NA NA NA hsa-miR-200b-3p ARHGAP26 2.11744072703209 1.66710572104191e-43 -1.50827592959053 4.39412178107472e-38 TargetScan -0.219379957196502 7.64078027165699e-18 NA NA NA hsa-miR-21-3p ARHGAP26 2.17476065946878 5.15299442583591e-75 -1.50827592959053 4.39412178107472e-38 mirMAP -0.16085584275285 5.40256702849087e-07 NA NA NA hsa-miR-429 ARHGAP26 2.84108892259147 3.88520896426515e-64 -1.50827592959053 4.39412178107472e-38 PITA;miRNATAP -0.214288608811315 3.23794332344213e-21 NA NA NA hsa-miR-200b-3p ARHGAP28 2.11744072703209 1.66710572104191e-43 -1.18133820684714 1.35940404125866e-14 MirTarget -0.367852292575954 9.07117006434399e-31 NA NA NA hsa-miR-200c-3p ARHGAP28 2.07038651806183 6.84613386286599e-51 -1.18133820684714 1.35940404125866e-14 MirTarget -0.433857431729715 1.44530249447599e-35 NA NA NA hsa-miR-429 ARHGAP28 2.84108892259147 3.88520896426515e-64 -1.18133820684714 1.35940404125866e-14 MirTarget -0.290708004696811 4.69031647995822e-24 NA NA NA hsa-miR-429 ARHGAP29 2.84108892259147 3.88520896426515e-64 -1.04674591283087 2.57670405699548e-18 miRanda -0.133950689805176 5.95544480602612e-09 NA NA NA hsa-miR-96-5p ARHGAP29 3.24596558166606 1.92296159041707e-98 -1.04674591283087 2.57670405699548e-18 TargetScan -0.132408307185009 3.71655128461936e-08 NA NA NA hsa-miR-21-3p ARHGAP36 2.17476065946878 5.15299442583591e-75 -3.65422823358327 9.03645795011857e-19 MirTarget -0.71363239580277 9.0444680650381e-11 NA NA NA hsa-miR-141-5p ARHGAP42 2.38411349683216 4.56310582620282e-58 -1.41678595729537 6.9118833128408e-26 MirTarget -0.243414665774574 1.00175644791079e-16 NA NA NA hsa-miR-182-5p ARHGAP6 2.36408084103818 2.60011457600281e-72 -1.65158600785283 1.63613207715144e-36 MirTarget -0.288104804152677 1.83809953570859e-19 NA NA NA hsa-miR-183-5p ARHGAP6 2.95681814393872 1.09965777344285e-92 -1.65158600785283 1.63613207715144e-36 MirTarget;miRNATAP -0.352150952228375 2.5034603341791e-37 NA NA NA hsa-miR-200b-3p ARHGAP6 2.11744072703209 1.66710572104191e-43 -1.65158600785283 1.63613207715144e-36 MirTarget;TargetScan -0.336161658840228 2.02541915108007e-33 NA NA NA hsa-miR-200c-3p ARHGAP6 2.07038651806183 6.84613386286599e-51 -1.65158600785283 1.63613207715144e-36 MirTarget -0.455407011389869 3.02891850245455e-52 NA NA NA hsa-miR-21-3p ARHGAP6 2.17476065946878 5.15299442583591e-75 -1.65158600785283 1.63613207715144e-36 MirTarget -0.35349699065837 6.79833776226938e-24 NA NA NA hsa-miR-429 ARHGAP6 2.84108892259147 3.88520896426515e-64 -1.65158600785283 1.63613207715144e-36 MirTarget;PITA;miRanda -0.319441219819649 4.64248745856946e-38 NA NA NA hsa-miR-96-5p ARHGAP6 3.24596558166606 1.92296159041707e-98 -1.65158600785283 1.63613207715144e-36 MirTarget;TargetScan -0.318625956760164 1.33186148358574e-34 NA NA NA hsa-miR-429 ARHGEF10 2.84108892259147 3.88520896426515e-64 -1.12289974702703 8.08121701116561e-39 miRanda -0.151679642529131 1.34391733977887e-19 NA NA NA hsa-miR-21-5p ARHGEF12 2.32007501846389 3.08394781855554e-137 -0.511720785410496 5.12937311441661e-09 miRNAWalker2_validate;MirTarget -0.236174559762799 2.02871487295618e-18 NA NA NA hsa-miR-182-5p ARHGEF4 2.36408084103818 2.60011457600281e-72 -1.84943424894393 1.55152257713431e-23 mirMAP -0.534070228321618 1.20093075427152e-34 NA NA NA hsa-miR-429 ARHGEF4 2.84108892259147 3.88520896426515e-64 -1.84943424894393 1.55152257713431e-23 miRNATAP -0.246042454342094 4.9956437142069e-12 NA NA NA hsa-miR-96-5p ARHGEF4 3.24596558166606 1.92296159041707e-98 -1.84943424894393 1.55152257713431e-23 mirMAP -0.400705656656195 3.51772914116352e-28 NA NA NA hsa-miR-200b-3p ARHGEF6 2.11744072703209 1.66710572104191e-43 -1.70444720138668 2.70249068312332e-44 mirMAP -0.284590975288989 7.43947398843613e-27 NA NA NA hsa-miR-429 ARHGEF6 2.84108892259147 3.88520896426515e-64 -1.70444720138668 2.70249068312332e-44 miRanda;mirMAP -0.292821968948748 6.51484995661843e-36 NA NA NA hsa-miR-182-5p ARHGEF7 2.36408084103818 2.60011457600281e-72 -0.61340240000199 3.98329005090064e-28 MirTarget;miRNATAP -0.109249484562175 5.53159065862441e-16 NA NA NA hsa-miR-21-3p ARHGEF7 2.17476065946878 5.15299442583591e-75 -0.61340240000199 3.98329005090064e-28 MirTarget -0.124129362535466 7.47200055803795e-17 NA NA NA hsa-miR-452-5p ARID2 -2.48486455572568 1.24430987974325e-33 0.0126196265480711 0.870504230097088 MirTarget -0.139877448467592 5.44443512586762e-32 NA NA NA hsa-miR-335-5p ARID3A -2.61355235628987 2.6462884165886e-51 0.815684149251337 1.2674402093826e-19 mirMAP -0.103873086391833 8.86415714387005e-10 NA NA NA hsa-miR-21-5p ARID4A 2.32007501846389 3.08394781855554e-137 -0.85847003194558 2.64031635907732e-29 miRNAWalker2_validate -0.303661902616789 4.46483636204476e-38 NA NA NA hsa-miR-429 ARID4A 2.84108892259147 3.88520896426515e-64 -0.85847003194558 2.64031635907732e-29 PITA;miRanda -0.118293571885655 9.78288065918773e-16 NA NA NA hsa-miR-96-5p ARID4A 3.24596558166606 1.92296159041707e-98 -0.85847003194558 2.64031635907732e-29 TargetScan -0.100645355722434 7.90402932185857e-11 NA NA NA hsa-miR-141-3p ARID5B 2.99777540204168 1.26370498493024e-78 -1.75348784333996 3.13677991957117e-58 TargetScan;miRNATAP -0.280948187617732 4.18108004318212e-38 NA NA NA hsa-miR-200a-3p ARID5B 2.55218480823434 2.96135446816238e-51 -1.75348784333996 3.13677991957117e-58 miRNATAP -0.243782580512392 1.53232763689101e-29 NA NA NA hsa-miR-200b-3p ARID5B 2.11744072703209 1.66710572104191e-43 -1.75348784333996 3.13677991957117e-58 TargetScan -0.250124110263959 4.1513307469872e-25 NA NA NA hsa-miR-429 ARID5B 2.84108892259147 3.88520896426515e-64 -1.75348784333996 3.13677991957117e-58 miRanda;miRNATAP -0.251409307178921 6.58060819312867e-32 NA NA NA hsa-miR-96-5p ARID5B 3.24596558166606 1.92296159041707e-98 -1.75348784333996 3.13677991957117e-58 TargetScan;miRNATAP -0.283899891280804 1.38375789908392e-37 NA NA NA hsa-miR-141-3p ARL10 2.99777540204168 1.26370498493024e-78 -1.27075340213045 4.44946132830112e-20 mirMAP -0.255875769218993 1.89378754462476e-21 NA NA NA hsa-miR-200a-3p ARL10 2.55218480823434 2.96135446816238e-51 -1.27075340213045 4.44946132830112e-20 mirMAP -0.225360892231359 2.02409156045167e-17 NA NA NA hsa-miR-200b-3p ARL10 2.11744072703209 1.66710572104191e-43 -1.27075340213045 4.44946132830112e-20 mirMAP -0.226791773718429 1.9535397625489e-14 NA NA NA hsa-miR-200c-3p ARL10 2.07038651806183 6.84613386286599e-51 -1.27075340213045 4.44946132830112e-20 mirMAP -0.26267365837357 6.6367374427532e-16 NA NA NA hsa-miR-21-3p ARL10 2.17476065946878 5.15299442583591e-75 -1.27075340213045 4.44946132830112e-20 mirMAP -0.149313979643357 6.07638857491404e-05 NA NA NA hsa-miR-429 ARL10 2.84108892259147 3.88520896426515e-64 -1.27075340213045 4.44946132830112e-20 mirMAP -0.222961504281958 2.71496963703586e-17 NA NA NA hsa-miR-200b-3p ARL15 2.11744072703209 1.66710572104191e-43 -0.940546011404162 6.29941456769943e-17 MirTarget -0.168231453421128 2.57781942131185e-12 NA NA NA hsa-miR-200c-3p ARL15 2.07038651806183 6.84613386286599e-51 -0.940546011404162 6.29941456769943e-17 MirTarget -0.218958943423556 7.83247406818381e-17 NA NA NA hsa-miR-429 ARL15 2.84108892259147 3.88520896426515e-64 -0.940546011404162 6.29941456769943e-17 MirTarget;PITA;miRanda -0.179602998997081 3.71519055416704e-17 NA NA NA hsa-miR-141-3p ARL4A 2.99777540204168 1.26370498493024e-78 -1.62430631843352 2.32437289801249e-48 TargetScan -0.227743863635866 1.88476218639659e-24 NA NA NA hsa-miR-141-5p ARL4A 2.38411349683216 4.56310582620282e-58 -1.62430631843352 2.32437289801249e-48 MirTarget -0.210689214150508 2.57597793723701e-17 NA NA NA hsa-miR-429 ARL4A 2.84108892259147 3.88520896426515e-64 -1.62430631843352 2.32437289801249e-48 miRanda;miRNATAP -0.18435268560897 4.66208880927508e-17 NA NA NA hsa-miR-182-5p ARL4C 2.36408084103818 2.60011457600281e-72 -0.639785018218124 8.71141470728812e-08 miRNATAP -0.302694826294605 1.19496255297945e-27 NA NA NA hsa-miR-375 ARL4C 2.09893673049766 1.68351780396203e-16 -0.639785018218124 8.71141470728812e-08 MirTarget;miRNATAP -0.177681572140081 3.66466523115312e-31 NA NA NA hsa-miR-96-5p ARL4C 3.24596558166606 1.92296159041707e-98 -0.639785018218124 8.71141470728812e-08 TargetScan;miRNATAP -0.234704924469216 3.82991917786965e-24 NA NA NA hsa-miR-139-5p ARL6IP1 -3.25846663863766 2.62018989415003e-112 0.766231218661411 6.70445718623255e-23 miRanda -0.1692323460653 2.49185411450087e-26 NA NA NA hsa-miR-139-5p ARL8A -3.25846663863766 2.62018989415003e-112 0.702591399384064 2.05412014740507e-32 miRanda -0.116975571865359 3.20689682256104e-21 NA NA NA hsa-miR-21-5p ARMC8 2.32007501846389 3.08394781855554e-137 -0.247947659425278 8.82411333468914e-07 miRNATAP -0.108180660940592 3.75734035519034e-12 NA NA NA hsa-miR-21-5p ARMCX1 2.32007501846389 3.08394781855554e-137 -0.66055906636068 5.01862991628344e-09 MirTarget -0.219371619018727 4.6249804997476e-10 NA NA NA hsa-miR-224-5p ARMCX2 -2.22249420723892 1.07787949391113e-18 0.0882791783524839 0.454061814860087 MirTarget -0.110254447297717 1.02544664704834e-12 NA NA NA hsa-miR-375 ARNTL2 2.09893673049766 1.68351780396203e-16 -0.174771177894593 0.36325839715442 miRNAWalker2_validate -0.223962155121219 1.69692527097408e-19 NA NA NA hsa-miR-335-5p ARPC5L -2.61355235628987 2.6462884165886e-51 1.01374809090137 4.06458053585457e-51 miRNAWalker2_validate;MirTarget -0.13073894978779 6.93776026892745e-24 NA NA NA hsa-miR-141-3p ARRB1 2.99777540204168 1.26370498493024e-78 -1.06393291402185 2.28886647765329e-23 MirTarget -0.169399514712247 7.04141832845205e-16 NA NA NA hsa-miR-200a-3p ARRB1 2.55218480823434 2.96135446816238e-51 -1.06393291402185 2.28886647765329e-23 MirTarget -0.11307553284225 5.52871088016413e-08 NA NA NA hsa-miR-182-5p ARRDC3 2.36408084103818 2.60011457600281e-72 -1.46664623321918 4.94729531970204e-49 MirTarget;miRNATAP -0.260906901264627 1.56089880647238e-26 NA NA NA hsa-miR-200b-3p ARRDC3 2.11744072703209 1.66710572104191e-43 -1.46664623321918 4.94729531970204e-49 TargetScan -0.187791490987278 1.63467196161948e-17 NA NA NA hsa-miR-429 ARRDC3 2.84108892259147 3.88520896426515e-64 -1.46664623321918 4.94729531970204e-49 PITA;miRanda;miRNATAP -0.194881833227178 1.93771931076995e-23 NA NA NA hsa-miR-96-5p ARRDC3 3.24596558166606 1.92296159041707e-98 -1.46664623321918 4.94729531970204e-49 TargetScan;miRNATAP -0.251143866829626 5.67170317555489e-36 NA NA NA hsa-miR-335-5p ARSI -2.61355235628987 2.6462884165886e-51 1.5287879898225 3.49783352669323e-18 miRNAWalker2_validate -0.256688613552001 5.59561774898347e-15 NA NA NA hsa-miR-96-5p ARSJ 3.24596558166606 1.92296159041707e-98 -0.607294580890688 6.77086363689826e-05 TargetScan;miRNATAP -0.149482474754477 6.83473622660491e-07 NA NA NA hsa-miR-182-5p ARSK 2.36408084103818 2.60011457600281e-72 -0.564115801202024 8.04183245107653e-14 MirTarget -0.109689413280543 1.35164608451348e-09 NA NA NA hsa-miR-21-5p ART4 2.32007501846389 3.08394781855554e-137 -3.25477828692448 4.49254549692587e-43 mirMAP -0.748328738243714 5.67447407910119e-23 NA NA NA hsa-miR-486-5p ARX -3.87258704301474 1.22658629378451e-80 0.324403202360278 0.324752031378221 miRanda -0.115224850108486 0.0213824571655361 NA NA NA hsa-miR-452-5p ASAH1 -2.48486455572568 1.24430987974325e-33 -0.241966784672597 0.0344822772264586 MirTarget -0.1019250046905 2.00296746116993e-08 NA NA NA hsa-miR-182-5p ASAP1 2.36408084103818 2.60011457600281e-72 -0.0548553794814568 0.497007616900824 mirMAP -0.103910471956679 5.18958457923889e-08 NA NA NA hsa-miR-200b-3p ASAP1 2.11744072703209 1.66710572104191e-43 -0.0548553794814568 0.497007616900824 MirTarget;TargetScan -0.112177041944169 3.33727389527842e-11 NA NA NA hsa-miR-200c-3p ASAP1 2.07038651806183 6.84613386286599e-51 -0.0548553794814568 0.497007616900824 MirTarget;miRNATAP -0.116341148591877 4.24555570728894e-10 NA NA NA hsa-miR-141-3p ASB1 2.99777540204168 1.26370498493024e-78 -0.931546146396313 1.15209695972474e-50 mirMAP -0.153851312045284 9.28909691694435e-36 NA NA NA hsa-miR-141-5p ASB1 2.38411349683216 4.56310582620282e-58 -0.931546146396313 1.15209695972474e-50 mirMAP -0.154716522120529 1.89884629226957e-29 NA NA NA hsa-miR-182-5p ASB1 2.36408084103818 2.60011457600281e-72 -0.931546146396313 1.15209695972474e-50 mirMAP -0.160787555435146 8.32605891512498e-26 NA NA NA hsa-miR-183-5p ASB1 2.95681814393872 1.09965777344285e-92 -0.931546146396313 1.15209695972474e-50 mirMAP -0.175794004002339 6.0004913753807e-40 NA NA NA hsa-miR-200a-3p ASB1 2.55218480823434 2.96135446816238e-51 -0.931546146396313 1.15209695972474e-50 mirMAP -0.116764738591083 2.70366908769873e-21 NA NA NA hsa-miR-21-3p ASB1 2.17476065946878 5.15299442583591e-75 -0.931546146396313 1.15209695972474e-50 MirTarget -0.199960414321893 7.885754010282e-33 NA NA NA hsa-miR-96-5p ASB1 3.24596558166606 1.92296159041707e-98 -0.931546146396313 1.15209695972474e-50 mirMAP -0.153772781242242 1.77010059144375e-34 NA NA NA hsa-miR-335-5p ASCL2 -2.61355235628987 2.6462884165886e-51 1.93362853675256 5.72020681071028e-20 miRNAWalker2_validate -0.255401308318253 1.41210631301492e-10 NA NA NA hsa-miR-141-3p ASPH 2.99777540204168 1.26370498493024e-78 -1.12086191770924 5.5588309537676e-19 MirTarget -0.239393973529425 9.54556491107484e-23 NA NA NA hsa-miR-200a-3p ASPH 2.55218480823434 2.96135446816238e-51 -1.12086191770924 5.5588309537676e-19 MirTarget -0.248624904622607 1.82700849189393e-25 NA NA NA hsa-miR-200b-3p ASPH 2.11744072703209 1.66710572104191e-43 -1.12086191770924 5.5588309537676e-19 MirTarget -0.271451416011742 1.52965360933306e-24 NA NA NA hsa-miR-200c-3p ASPH 2.07038651806183 6.84613386286599e-51 -1.12086191770924 5.5588309537676e-19 MirTarget -0.291821248227008 1.82468422060917e-23 NA NA NA hsa-miR-429 ASPH 2.84108892259147 3.88520896426515e-64 -1.12086191770924 5.5588309537676e-19 MirTarget;miRanda;miRNATAP -0.242454799616 1.49021072728045e-24 NA NA NA hsa-miR-139-5p ASPN -3.25846663863766 2.62018989415003e-112 1.39201096647563 8.35003556205803e-11 miRanda -0.213712095413955 1.52158786536093e-06 NA NA NA hsa-miR-335-5p ASPN -2.61355235628987 2.6462884165886e-51 1.39201096647563 8.35003556205803e-11 miRNAWalker2_validate -0.201154317560555 5.21494044288271e-07 NA NA NA hsa-miR-429 ASPN 2.84108892259147 3.88520896426515e-64 1.39201096647563 8.35003556205803e-11 miRanda -0.135765612871211 0.00093972330978617 NA NA NA hsa-miR-141-3p ASTN1 2.99777540204168 1.26370498493024e-78 -2.96085678510482 6.59267881470187e-30 MirTarget;miRNATAP -0.524681039602948 9.72053126549743e-25 NA NA NA hsa-miR-182-5p ASTN1 2.36408084103818 2.60011457600281e-72 -2.96085678510482 6.59267881470187e-30 miRNATAP -0.535588156816317 2.49995808559766e-17 NA NA NA hsa-miR-200a-3p ASTN1 2.55218480823434 2.96135446816238e-51 -2.96085678510482 6.59267881470187e-30 MirTarget;miRNATAP -0.35966082246518 1.67131671710867e-12 NA NA NA hsa-miR-96-5p ASTN1 3.24596558166606 1.92296159041707e-98 -2.96085678510482 6.59267881470187e-30 TargetScan;miRNATAP -0.572254280929457 1.83358320967054e-28 NA NA NA hsa-miR-429 ASXL2 2.84108892259147 3.88520896426515e-64 -0.863091823045132 1.23718078543405e-08 miRNATAP -0.146694123513359 3.526225002995e-07 NA NA NA hsa-miR-141-3p ASXL3 2.99777540204168 1.26370498493024e-78 -2.85950771371795 2.17967881661421e-39 TargetScan -0.487615242095634 6.68305587565936e-30 NA NA NA hsa-miR-182-5p ASXL3 2.36408084103818 2.60011457600281e-72 -2.85950771371795 2.17967881661421e-39 mirMAP -0.447936458867401 5.86491402312519e-17 NA NA NA hsa-miR-200b-3p ASXL3 2.11744072703209 1.66710572104191e-43 -2.85950771371795 2.17967881661421e-39 TargetScan -0.403978272871675 2.2026960754013e-17 NA NA NA hsa-miR-429 ASXL3 2.84108892259147 3.88520896426515e-64 -2.85950771371795 2.17967881661421e-39 miRanda -0.413872649628398 1.12105518004704e-22 NA NA NA hsa-miR-200a-3p ATE1 2.55218480823434 2.96135446816238e-51 -0.716130141253612 1.69873538155502e-08 MirTarget -0.117478135244148 1.34073680493748e-06 NA NA NA hsa-miR-21-5p ATF2 2.32007501846389 3.08394781855554e-137 -0.526197310314373 1.91997984112617e-07 miRNAWalker2_validate -0.231001727277097 1.50432513865861e-13 NA NA NA hsa-miR-429 ATF3 2.84108892259147 3.88520896426515e-64 -2.24773639708619 3.16383507385652e-38 miRanda -0.265048772748715 6.56342403970864e-15 NA NA NA hsa-miR-200b-3p ATF7 2.11744072703209 1.66710572104191e-43 -0.8075699517726 1.70008219567476e-38 mirMAP -0.10198500385476 7.26290508917116e-14 NA NA NA hsa-miR-429 ATF7 2.84108892259147 3.88520896426515e-64 -0.8075699517726 1.70008219567476e-38 miRanda;miRNATAP -0.110430850105188 5.82486442212167e-20 NA NA NA hsa-miR-141-3p ATG2B 2.99777540204168 1.26370498493024e-78 -0.6886793008584 1.71011793794089e-19 MirTarget -0.103930680521897 3.85991814317682e-12 NA NA NA hsa-miR-429 ATG2B 2.84108892259147 3.88520896426515e-64 -0.6886793008584 1.71011793794089e-19 miRNATAP -0.109957728478979 4.11145540262783e-14 NA NA NA hsa-miR-139-5p ATG4D -3.25846663863766 2.62018989415003e-112 1.02352423704473 3.18914756984571e-37 PITA;miRanda -0.167174172654265 3.17263952445435e-23 NA NA NA hsa-miR-21-5p ATM 2.32007501846389 3.08394781855554e-137 -0.753520785022149 8.14866377341274e-18 mirMAP -0.230974664847653 3.0596374789676e-17 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-21-5p ATMIN 2.32007501846389 3.08394781855554e-137 -0.364988189930998 1.79193773621807e-10 miRNAWalker2_validate -0.16057955550825 6.99755948412333e-20 NA NA NA hsa-miR-96-5p ATOH8 3.24596558166606 1.92296159041707e-98 -3.72642460023598 1.4935193366005e-77 TargetScan -0.688267164069082 8.65908960807946e-66 NA NA NA hsa-miR-182-5p ATP10A 2.36408084103818 2.60011457600281e-72 0.0675258656158877 0.571274939906755 mirMAP -0.124134940539939 1.1467865674876e-05 NA NA NA hsa-miR-183-5p ATP10B 2.95681814393872 1.09965777344285e-92 -1.05122410430748 8.45871672672733e-05 MirTarget -0.138215636540529 0.0146270047409902 NA NA NA hsa-miR-182-5p ATP10D 2.36408084103818 2.60011457600281e-72 -0.778443829167676 4.63140872237443e-15 MirTarget -0.1994812984811 3.03254922497957e-17 NA NA NA hsa-miR-375 ATP11A 2.09893673049766 1.68351780396203e-16 -0.673980457445118 8.86149792375753e-09 mirMAP -0.114363085345768 1.0097604258537e-13 NA NA NA hsa-miR-200b-3p ATP11B 2.11744072703209 1.66710572104191e-43 -0.93480335074252 2.43097161001357e-15 TargetScan -0.198360455198706 2.54957794634043e-15 NA NA NA hsa-miR-21-5p ATP11B 2.32007501846389 3.08394781855554e-137 -0.93480335074252 2.43097161001357e-15 miRNAWalker2_validate -0.186514892424103 5.53443040117541e-07 NA NA NA hsa-miR-429 ATP11B 2.84108892259147 3.88520896426515e-64 -0.93480335074252 2.43097161001357e-15 PITA;miRanda;miRNATAP -0.143486842281275 1.92389627553438e-10 NA NA NA hsa-miR-200b-3p ATP11C 2.11744072703209 1.66710572104191e-43 -0.696460875250057 2.28099753397118e-14 MirTarget;TargetScan -0.173367270880293 1.99961655117013e-19 NA NA NA hsa-miR-200c-3p ATP11C 2.07038651806183 6.84613386286599e-51 -0.696460875250057 2.28099753397118e-14 MirTarget -0.146062845925123 8.12451102058996e-12 NA NA NA hsa-miR-429 ATP11C 2.84108892259147 3.88520896426515e-64 -0.696460875250057 2.28099753397118e-14 MirTarget;PITA;miRanda;miRNATAP -0.131276964757878 3.18633411399037e-14 NA NA NA hsa-miR-429 ATP1A2 2.84108892259147 3.88520896426515e-64 -5.48067784930998 5.76779392290717e-74 miRNATAP -0.909332645216418 2.68141944921978e-54 NA NA NA hsa-miR-429 ATP1B2 2.84108892259147 3.88520896426515e-64 -1.90231916229878 1.04585268498219e-40 miRNATAP -0.292419977667829 2.26109574436369e-26 NA NA NA hsa-miR-335-5p ATP2A3 -2.61355235628987 2.6462884165886e-51 1.21509823213349 2.07471726356824e-14 mirMAP -0.122603991161625 4.19691587301899e-05 NA NA NA hsa-miR-429 ATP2B1 2.84108892259147 3.88520896426515e-64 -0.637952928825792 3.60512245786879e-13 PITA;miRanda -0.13716777552727 1.16944415917079e-16 NA NA NA hsa-miR-21-5p ATP2B2 2.32007501846389 3.08394781855554e-137 -1.34957995729632 1.72560555576886e-08 mirMAP -0.264895951143355 0.000425195638483669 NA NA NA hsa-miR-429 ATP2B2 2.84108892259147 3.88520896426515e-64 -1.34957995729632 1.72560555576886e-08 miRanda;miRNATAP -0.180268464788045 7.81421291074569e-05 NA NA NA hsa-miR-182-5p ATP2B4 2.36408084103818 2.60011457600281e-72 -1.10970839530794 1.00950124162395e-28 mirMAP -0.207882591479435 7.2971875621216e-18 NA NA NA hsa-miR-183-5p ATP2B4 2.95681814393872 1.09965777344285e-92 -1.10970839530794 1.00950124162395e-28 MirTarget;miRNATAP -0.180605492540197 2.8789488012651e-17 NA NA NA hsa-miR-21-3p ATP2B4 2.17476065946878 5.15299442583591e-75 -1.10970839530794 1.00950124162395e-28 mirMAP -0.118094287386485 1.32229041389531e-05 NA NA NA hsa-miR-21-5p ATP2B4 2.32007501846389 3.08394781855554e-137 -1.10970839530794 1.00950124162395e-28 miRNAWalker2_validate;MirTarget -0.269541901543463 1.44759461871948e-17 NA NA NA hsa-miR-96-5p ATP2B4 3.24596558166606 1.92296159041707e-98 -1.10970839530794 1.00950124162395e-28 MirTarget;TargetScan -0.206134699929339 2.71102253026733e-25 NA NA NA hsa-miR-99a-5p ATP5E -2.25079447371102 1.14086813185885e-54 0.52926098948594 3.93367245155208e-11 miRNAWalker2_validate -0.133427373997759 4.47379082739271e-14 NA NA NA hsa-miR-335-5p ATP6V0D2 -2.61355235628987 2.6462884165886e-51 1.95017221142106 1.89798686080921e-15 miRNAWalker2_validate -0.314531397836545 7.07460085514163e-12 NA NA NA hsa-miR-141-3p ATP8A1 2.99777540204168 1.26370498493024e-78 -1.26773424605015 1.41240612435128e-18 MirTarget;TargetScan -0.207098946249202 2.27002269011341e-13 NA NA NA hsa-miR-182-5p ATP8A1 2.36408084103818 2.60011457600281e-72 -1.26773424605015 1.41240612435128e-18 MirTarget;miRNATAP -0.202569097464204 6.01944827666831e-09 NA NA NA hsa-miR-200a-3p ATP8A1 2.55218480823434 2.96135446816238e-51 -1.26773424605015 1.41240612435128e-18 MirTarget -0.184709409618299 3.00159404534449e-11 NA NA NA hsa-miR-429 ATP8A1 2.84108892259147 3.88520896426515e-64 -1.26773424605015 1.41240612435128e-18 miRanda;miRNATAP -0.198690081286283 5.38162182433767e-13 NA NA NA hsa-miR-96-5p ATP8A1 3.24596558166606 1.92296159041707e-98 -1.26773424605015 1.41240612435128e-18 TargetScan;miRNATAP -0.19309217325894 2.03306671901923e-11 NA NA NA hsa-miR-141-3p ATP8A2 2.99777540204168 1.26370498493024e-78 -0.638077713608567 0.00506971588278745 TargetScan -0.184472539211495 3.00620922741722e-05 NA NA NA hsa-miR-96-5p ATP8A2 3.24596558166606 1.92296159041707e-98 -0.638077713608567 0.00506971588278745 mirMAP -0.153045415916103 0.000678935026202677 NA NA NA hsa-miR-511-5p ATP8B3 -2.27545475897362 3.84085514050558e-36 0.997224411876316 3.04254650139559e-12 MirTarget -0.134796050699302 2.76815365240172e-07 NA NA NA hsa-miR-200a-5p ATP8B4 2.58844508672328 1.79650654234569e-56 -1.46395699677557 8.64693942273057e-35 MirTarget -0.24602636505567 1.49382496321569e-25 NA NA NA hsa-miR-200a-3p ATP9A 2.55218480823434 2.96135446816238e-51 -0.610933422922605 2.88362006166621e-10 mirMAP -0.11122818353066 1.87847912692278e-09 NA NA NA hsa-miR-429 ATP9A 2.84108892259147 3.88520896426515e-64 -0.610933422922605 2.88362006166621e-10 miRNATAP -0.107107921870168 5.83739027570805e-09 NA NA NA hsa-miR-21-5p ATRN 2.32007501846389 3.08394781855554e-137 -0.252443806646194 4.51825757053006e-05 miRNATAP -0.102465597038997 9.54242964779537e-08 NA NA NA hsa-miR-21-3p ATRNL1 2.17476065946878 5.15299442583591e-75 -0.735629381854826 0.0208064652732134 MirTarget -0.173635844925575 0.0386176475067617 NA NA NA hsa-miR-21-5p ATRX 2.32007501846389 3.08394781855554e-137 -0.588096949367589 2.18288240478198e-12 miRNAWalker2_validate -0.249265222441734 4.06831173161553e-22 NA NA NA hsa-miR-141-3p ATXN1 2.99777540204168 1.26370498493024e-78 -0.114435417261807 0.172447028305803 MirTarget;TargetScan;miRNATAP -0.102729733109084 1.8797304555441e-10 NA NA NA hsa-miR-200c-3p ATXN1 2.07038651806183 6.84613386286599e-51 -0.114435417261807 0.172447028305803 MirTarget;miRNATAP -0.106226800982093 4.42599639047694e-08 NA NA NA hsa-miR-141-3p ATXN1L 2.99777540204168 1.26370498493024e-78 -0.967047544306038 3.56077228221018e-35 mirMAP -0.137643141167723 7.54787476623612e-19 NA NA NA hsa-miR-182-5p ATXN1L 2.36408084103818 2.60011457600281e-72 -0.967047544306038 3.56077228221018e-35 mirMAP -0.142646339484058 9.66348479657854e-14 NA NA NA hsa-miR-200a-3p ATXN1L 2.55218480823434 2.96135446816238e-51 -0.967047544306038 3.56077228221018e-35 mirMAP -0.118089190502755 1.25634516696957e-14 NA NA NA hsa-miR-200b-3p ATXN1L 2.11744072703209 1.66710572104191e-43 -0.967047544306038 3.56077228221018e-35 TargetScan -0.124050588853429 3.64636204609545e-13 NA NA NA hsa-miR-200c-3p ATXN1L 2.07038651806183 6.84613386286599e-51 -0.967047544306038 3.56077228221018e-35 miRNATAP -0.140101059576771 7.94636330797225e-14 NA NA NA hsa-miR-429 ATXN1L 2.84108892259147 3.88520896426515e-64 -0.967047544306038 3.56077228221018e-35 miRNATAP -0.118328796024309 7.17477935150223e-15 NA NA NA hsa-miR-96-5p ATXN1L 3.24596558166606 1.92296159041707e-98 -0.967047544306038 3.56077228221018e-35 TargetScan -0.142725830785694 1.4585385935492e-19 NA NA NA hsa-miR-21-5p ATXN3 2.32007501846389 3.08394781855554e-137 -0.494813029028878 1.49248009587331e-21 mirMAP -0.169424226002042 4.68207024107888e-26 NA NA NA hsa-miR-145-5p ATXN7L3 -2.62703571936687 7.64402900188551e-88 0.53052790945832 3.35458942024545e-29 miRNATAP -0.10671594149144 5.08653026614155e-22 NA NA NA hsa-miR-21-5p AUTS2 2.32007501846389 3.08394781855554e-137 -0.128757187472162 0.220594677633699 miRNAWalker2_validate -0.109212629368038 0.000838210478213721 NA NA NA hsa-miR-375 AVPR1A 2.09893673049766 1.68351780396203e-16 -2.10367215895108 3.94317714451875e-27 miRanda -0.107652595021722 4.92756746945447e-05 NA NA NA hsa-miR-126-5p AXIN1 -1.27745588751177 2.96000918537631e-30 1.01334328266797 2.98400439093595e-40 miRNATAP -0.232873177453548 6.89302611938727e-24 NA NA NA hsa-miR-335-5p AXIN1 -2.61355235628987 2.6462884165886e-51 1.01334328266797 2.98400439093595e-40 miRNAWalker2_validate -0.142684376401892 7.8023220735108e-23 NA NA NA hsa-miR-539-5p AXIN1 -1.28530285996605 1.62620330363951e-14 1.01334328266797 2.98400439093595e-40 miRNATAP -0.162890931040002 4.17509848174996e-25 NA NA NA hsa-let-7a-3p AXIN2 0.466622567891891 3.70886257943079e-07 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.155309998742421 0.00126021107839157 NA NA NA hsa-let-7g-3p AXIN2 0.5854327663695 0.000371711766083627 -0.895665130901764 2.13015726395378e-12 MirTarget -0.15927262941163 2.22164738358529e-09 NA NA NA hsa-miR-103a-3p AXIN2 0.610673390034345 1.63113920514646e-12 -0.895665130901764 2.13015726395378e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.200585660302729 7.71528936514313e-05 NA NA NA hsa-miR-107 AXIN2 0.678998026350662 2.56224148930538e-16 -0.895665130901764 2.13015726395378e-12 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.313818454372385 2.10386522757559e-09 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-15a-5p AXIN2 0.812445324157528 4.50263417099822e-20 -0.895665130901764 2.13015726395378e-12 MirTarget;miRNATAP -0.308482083886854 2.3359131858061e-10 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.788659356634696 1.13678211092534e-11 -0.895665130901764 2.13015726395378e-12 miRTarBase;MirTarget;miRNATAP -0.249089153159517 2.51640038854339e-11 NA NA NA hsa-miR-16-2-3p AXIN2 0.286355254959005 0.0256946046884474 -0.895665130901764 2.13015726395378e-12 mirMAP -0.242354247916614 1.68855735572963e-12 NA NA NA hsa-miR-16-5p AXIN2 0.46835991343556 1.91125356547776e-06 -0.895665130901764 2.13015726395378e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.250388265601038 2.07986806159543e-08 NA NA NA hsa-miR-221-3p AXIN2 -0.317970198201501 0.00910855267413448 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.187234880985831 2.24061800824779e-07 NA NA NA hsa-miR-222-3p AXIN2 -0.429279381480379 0.00103945569781115 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.187336402293767 2.41688030584989e-08 NA NA NA hsa-miR-29a-5p AXIN2 0.334183773952055 0.00445137265870197 -0.895665130901764 2.13015726395378e-12 MirTarget -0.206530050833047 3.89834897393732e-08 NA NA NA hsa-miR-429 AXIN2 2.84108892259147 3.88520896426515e-64 -0.895665130901764 2.13015726395378e-12 miRanda -0.190517672757253 2.55529446378965e-15 NA NA NA hsa-miR-582-5p AXIN2 0.201134299470983 0.149482495292227 -0.895665130901764 2.13015726395378e-12 miRNATAP -0.23410335462888 1.51202842984391e-13 NA NA NA hsa-miR-590-3p AXIN2 1.27438512890514 1.03164723481469e-23 -0.895665130901764 2.13015726395378e-12 MirTarget;PITA;miRanda;miRNATAP -0.363534362507334 4.95187752463635e-26 NA NA NA hsa-miR-139-5p AZIN1 -3.25846663863766 2.62018989415003e-112 0.275143872158873 0.000912212129632399 PITA;miRanda;miRNATAP -0.109411913411292 1.03319358975824e-10 NA NA NA hsa-miR-378a-5p B3GALNT1 -2.43173551693523 1.44932837789175e-68 0.696059420178472 2.25548835294228e-15 MirTarget -0.138685669144999 3.86340278549625e-12 NA NA NA hsa-miR-139-5p B3GALNT2 -3.25846663863766 2.62018989415003e-112 0.461277916869801 3.58506595555061e-11 MirTarget;miRanda -0.130393666083072 3.49819691231945e-20 NA NA NA hsa-miR-141-3p B3GALT1 2.99777540204168 1.26370498493024e-78 -3.98103430858862 1.44388634349729e-75 TargetScan -0.559992845905164 1.26341448750432e-36 NA NA NA hsa-miR-182-5p B3GALT1 2.36408084103818 2.60011457600281e-72 -3.98103430858862 1.44388634349729e-75 MirTarget -0.612153539192687 6.51058443811684e-29 NA NA NA hsa-miR-96-5p B3GALT1 3.24596558166606 1.92296159041707e-98 -3.98103430858862 1.44388634349729e-75 TargetScan -0.644925832954677 8.66192362137348e-48 NA NA NA hsa-miR-429 B3GALT2 2.84108892259147 3.88520896426515e-64 -1.53903105478403 1.70857657204927e-23 miRNATAP -0.267156188481165 9.34001683134314e-20 NA NA NA hsa-miR-96-5p B3GALT2 3.24596558166606 1.92296159041707e-98 -1.53903105478403 1.70857657204927e-23 TargetScan -0.323174834744903 2.04527288658632e-26 NA NA NA hsa-miR-429 B3GAT1 2.84108892259147 3.88520896426515e-64 -2.11312336809992 2.59132407338222e-15 miRanda -0.168614512079904 0.00105286029694957 NA NA NA hsa-miR-335-5p B3GNT4 -2.61355235628987 2.6462884165886e-51 1.45308835223445 1.71120256443891e-12 miRNAWalker2_validate -0.270047558133728 1.82376396511482e-12 NA NA NA hsa-miR-141-3p B3GNT5 2.99777540204168 1.26370498493024e-78 -1.53531290629438 1.16098549639906e-19 TargetScan -0.188491236928403 1.72284861583692e-08 NA NA NA hsa-miR-21-5p B3GNT5 2.32007501846389 3.08394781855554e-137 -1.53531290629438 1.16098549639906e-19 miRNAWalker2_validate -0.309601402077663 7.56979187542241e-09 NA NA NA hsa-miR-10b-5p B3GNT7 -2.10996264627796 7.36811595736367e-72 0.20197704665887 0.160247514546483 mirMAP -0.242158650596214 1.75552352403426e-10 NA NA NA hsa-miR-182-5p B3GNT7 2.36408084103818 2.60011457600281e-72 0.20197704665887 0.160247514546483 mirMAP -0.185302650268695 5.22512866571041e-08 NA NA NA hsa-miR-139-3p B4GALT1 -3.44089023199323 1.67292890850702e-91 0.556427348763504 5.87065351506132e-11 MirTarget -0.120613038376704 2.62216415611747e-15 NA NA NA hsa-miR-200b-3p B4GALT6 2.11744072703209 1.66710572104191e-43 -1.52811154944873 8.28896953314112e-40 MirTarget -0.217522704740941 8.03293650410985e-18 NA NA NA hsa-miR-200c-3p B4GALT6 2.07038651806183 6.84613386286599e-51 -1.52811154944873 8.28896953314112e-40 MirTarget;miRNATAP -0.241418214675955 3.86818529215459e-18 NA NA NA hsa-miR-21-3p B4GALT6 2.17476065946878 5.15299442583591e-75 -1.52811154944873 8.28896953314112e-40 MirTarget -0.194370573470502 9.02798639143024e-10 NA NA NA hsa-miR-429 B4GALT6 2.84108892259147 3.88520896426515e-64 -1.52811154944873 8.28896953314112e-40 MirTarget;miRanda;miRNATAP -0.204125120722769 1.32821028735895e-19 NA NA NA hsa-miR-141-3p BACE1 2.99777540204168 1.26370498493024e-78 -0.666769604583787 2.96043912347582e-20 TargetScan;miRNATAP -0.172123154005193 7.39237012295794e-36 NA NA NA hsa-miR-182-5p BACE1 2.36408084103818 2.60011457600281e-72 -0.666769604583787 2.96043912347582e-20 mirMAP -0.17840534681972 1.88480866091113e-25 NA NA NA hsa-miR-200a-3p BACE1 2.55218480823434 2.96135446816238e-51 -0.666769604583787 2.96043912347582e-20 mirMAP;miRNATAP -0.150780816777556 2.12822618790304e-28 NA NA NA hsa-miR-21-5p BACE1 2.32007501846389 3.08394781855554e-137 -0.666769604583787 2.96043912347582e-20 mirMAP -0.185541233410245 2.62207018874446e-16 NA NA NA hsa-miR-429 BACE1 2.84108892259147 3.88520896426515e-64 -0.666769604583787 2.96043912347582e-20 miRNATAP -0.141293910190416 2.89446005109716e-25 NA NA NA hsa-miR-96-5p BACE1 3.24596558166606 1.92296159041707e-98 -0.666769604583787 2.96043912347582e-20 mirMAP -0.168516305690208 4.02051388473124e-33 NA NA NA hsa-miR-182-5p BACE2 2.36408084103818 2.60011457600281e-72 0.121791353053033 0.368718593447756 miRNATAP -0.138694530364307 1.61166343845607e-05 NA NA NA hsa-miR-141-3p BACH2 2.99777540204168 1.26370498493024e-78 -1.73835492420195 2.12716972085336e-31 TargetScan -0.350944611352891 7.40934421569497e-34 NA NA NA hsa-miR-141-5p BACH2 2.38411349683216 4.56310582620282e-58 -1.73835492420195 2.12716972085336e-31 miRNATAP -0.280348398637724 9.07267200828856e-18 NA NA NA hsa-miR-182-5p BACH2 2.36408084103818 2.60011457600281e-72 -1.73835492420195 2.12716972085336e-31 MirTarget;mirMAP;miRNATAP -0.44323682520613 4.95826715603549e-36 NA NA NA hsa-miR-183-5p BACH2 2.95681814393872 1.09965777344285e-92 -1.73835492420195 2.12716972085336e-31 MirTarget;miRNATAP -0.381941824126365 3.95390413002429e-34 NA NA NA hsa-miR-200a-3p BACH2 2.55218480823434 2.96135446816238e-51 -1.73835492420195 2.12716972085336e-31 mirMAP -0.288332992592871 1.23167881048994e-23 NA NA NA hsa-miR-200b-3p BACH2 2.11744072703209 1.66710572104191e-43 -1.73835492420195 2.12716972085336e-31 TargetScan;mirMAP -0.279239130616483 4.6547126152686e-18 NA NA NA hsa-miR-200c-3p BACH2 2.07038651806183 6.84613386286599e-51 -1.73835492420195 2.12716972085336e-31 mirMAP -0.343576698109244 1.88017069684532e-22 NA NA NA hsa-miR-375 BACH2 2.09893673049766 1.68351780396203e-16 -1.73835492420195 2.12716972085336e-31 miRNATAP -0.203715960596408 1.15984449737563e-24 NA NA NA hsa-miR-429 BACH2 2.84108892259147 3.88520896426515e-64 -1.73835492420195 2.12716972085336e-31 PITA;mirMAP;miRNATAP -0.272115364539131 2.2252557267792e-21 NA NA NA hsa-miR-96-5p BACH2 3.24596558166606 1.92296159041707e-98 -1.73835492420195 2.12716972085336e-31 TargetScan;miRNATAP -0.412917329218286 3.9997033017593e-46 NA NA NA hsa-miR-375 BAHCC1 2.09893673049766 1.68351780396203e-16 -0.346869553943518 0.00681890850135577 PITA;miRanda -0.109337268820015 6.76809747547893e-11 NA NA NA hsa-miR-139-5p BANP -3.25846663863766 2.62018989415003e-112 0.536218606770472 1.27813900761587e-17 miRanda -0.102615013462745 2.25670861111432e-15 NA NA NA hsa-miR-139-5p BASP1 -3.25846663863766 2.62018989415003e-112 1.15434272740357 5.93241359054435e-21 miRanda -0.117754399956619 5.17887138100347e-06 NA NA NA hsa-miR-139-5p BAZ1A -3.25846663863766 2.62018989415003e-112 0.383720840308036 1.06513150396219e-07 miRanda -0.104648501814552 1.35920052618804e-12 NA NA NA hsa-miR-139-5p BBC3 -3.25846663863766 2.62018989415003e-112 1.65385724902316 1.48973116107111e-30 miRNATAP -0.224614533926346 1.3398029460868e-13 NA NA NA hsa-miR-21-5p BBS12 2.32007501846389 3.08394781855554e-137 -0.652445393391132 2.23658125253734e-18 MirTarget -0.225343894639492 1.99713954600638e-22 NA NA NA hsa-miR-200c-3p BCAP29 2.07038651806183 6.84613386286599e-51 -0.283272713723518 1.20011320724944e-05 MirTarget -0.100891380466071 1.57910803733562e-11 NA NA NA hsa-miR-452-5p BCAS1 -2.48486455572568 1.24430987974325e-33 1.42932487415414 6.29824541676676e-06 mirMAP -0.653153229792534 1.33230017711067e-41 NA NA NA hsa-miR-429 BCHE 2.84108892259147 3.88520896426515e-64 -2.6752527973964 1.70845739558869e-33 miRanda -0.456421069542576 5.71838652421938e-27 NA NA NA hsa-miR-182-5p BCL11B 2.36408084103818 2.60011457600281e-72 -0.256836470376791 0.197473897494306 mirMAP -0.245704763800067 1.94247715834801e-07 NA NA NA hsa-miR-183-5p BCL11B 2.95681814393872 1.09965777344285e-92 -0.256836470376791 0.197473897494306 miRNAWalker2_validate;miRNATAP -0.122141151184174 0.00362069214301212 NA NA NA hsa-miR-375 BCL11B 2.09893673049766 1.68351780396203e-16 -0.256836470376791 0.197473897494306 miRanda -0.164781850839961 2.44247942885145e-10 NA NA NA hsa-miR-96-5p BCL11B 3.24596558166606 1.92296159041707e-98 -0.256836470376791 0.197473897494306 mirMAP -0.200714650260405 3.00821332038401e-07 NA NA NA hsa-miR-21-5p BCL2 2.32007501846389 3.08394781855554e-137 -0.895845361347303 1.04475176246219e-07 miRNAWalker2_validate;miRTarBase -0.486116466611641 4.94993012898121e-21 26555418;21468550;25994220;25381586;23359184;22964582;21376256 The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance breast cancer;bladder cancer;colorectal cancer;sarcoma;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-224-5p BCL2 -2.22249420723892 1.07787949391113e-18 -0.895845361347303 1.04475176246219e-07 mirMAP -0.241222882395465 2.18051025428057e-28 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-429 BCL2 2.84108892259147 3.88520896426515e-64 -0.895845361347303 1.04475176246219e-07 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.121974754205047 0.000143492269579093 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-452-5p BCL2 -2.48486455572568 1.24430987974325e-33 -0.895845361347303 1.04475176246219e-07 mirMAP -0.281160548783898 1.07099917549241e-26 NA NA NA hsa-miR-335-5p BCL2A1 -2.61355235628987 2.6462884165886e-51 0.844828872050699 3.10856163070141e-06 miRNAWalker2_validate -0.136444655653728 5.30905961072346e-05 NA NA NA hsa-miR-375 BCL2L14 2.09893673049766 1.68351780396203e-16 -0.132595342308931 0.582047414772611 miRanda -0.160600909480514 3.69079254561893e-07 NA NA NA hsa-miR-429 BCL2L2 2.84108892259147 3.88520896426515e-64 -0.924709648584916 1.52019896581532e-46 miRNATAP -0.100252536550211 3.48953888760225e-15 NA NA NA hsa-miR-183-5p BCL6 2.95681814393872 1.09965777344285e-92 -1.26229162888298 9.95816785471049e-39 miRNATAP -0.276589802957388 5.14962465655933e-42 NA NA NA hsa-miR-21-5p BCL6 2.32007501846389 3.08394781855554e-137 -1.26229162888298 9.95816785471049e-39 miRNAWalker2_validate -0.304933247079297 5.43036581452504e-23 NA NA NA hsa-miR-429 BCL6 2.84108892259147 3.88520896426515e-64 -1.26229162888298 9.95816785471049e-39 miRanda -0.188870802242468 7.11211556294978e-24 NA NA NA hsa-miR-21-5p BDH2 2.32007501846389 3.08394781855554e-137 -0.901158842188178 1.35548768101197e-27 miRNAWalker2_validate -0.191806202169956 3.08631392543743e-13 NA NA NA hsa-miR-182-5p BDNF 2.36408084103818 2.60011457600281e-72 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.234588678348713 3.99165896393269e-06 NA NA NA hsa-miR-210-3p BDNF 2.38367203491819 3.73261999106754e-22 -1.60102244727579 3.13378744159785e-14 miRNAWalker2_validate;miRTarBase -0.115495455176462 6.58638340303894e-05 NA NA NA hsa-miR-375 BEND6 2.09893673049766 1.68351780396203e-16 0.598060035281371 2.48277797233464e-05 miRanda -0.127373899846287 6.9662752836418e-12 NA NA NA hsa-miR-335-5p BFSP2 -2.61355235628987 2.6462884165886e-51 1.4772559871896 1.16785129644944e-09 miRNAWalker2_validate -0.208221846238969 4.49227325033942e-06 NA NA NA hsa-miR-486-5p BGN -3.87258704301474 1.22658629378451e-80 2.33977700772477 1.83447359500135e-74 miRanda -0.212880218996298 1.3509058714132e-24 NA NA NA hsa-miR-182-5p BHLHE22 2.36408084103818 2.60011457600281e-72 -0.885533409707188 1.61361696091456e-08 MirTarget;miRNATAP -0.270839779020927 3.20347772260688e-13 NA NA NA hsa-miR-429 BHLHE22 2.84108892259147 3.88520896426515e-64 -0.885533409707188 1.61361696091456e-08 miRanda -0.250430402023145 1.55056858089217e-17 NA NA NA hsa-miR-96-5p BHLHE22 3.24596558166606 1.92296159041707e-98 -0.885533409707188 1.61361696091456e-08 TargetScan -0.298596874730853 1.09631132119028e-22 NA NA NA hsa-miR-182-5p BHLHE41 2.36408084103818 2.60011457600281e-72 -1.52791209922438 3.58240496427099e-30 miRNATAP -0.245102118374228 5.8523261248626e-14 NA NA NA hsa-miR-200b-3p BHLHE41 2.11744072703209 1.66710572104191e-43 -1.52791209922438 3.58240496427099e-30 MirTarget;TargetScan -0.189675934129512 7.87834639798827e-11 NA NA NA hsa-miR-200c-3p BHLHE41 2.07038651806183 6.84613386286599e-51 -1.52791209922438 3.58240496427099e-30 MirTarget;miRNATAP -0.218575068442399 8.90412851610278e-12 NA NA NA hsa-miR-429 BHLHE41 2.84108892259147 3.88520896426515e-64 -1.52791209922438 3.58240496427099e-30 MirTarget;miRanda;miRNATAP -0.210472434947991 4.03149487317306e-16 NA NA NA hsa-miR-200b-3p BICC1 2.11744072703209 1.66710572104191e-43 -1.8344531920319 2.52630597418105e-16 TargetScan -0.436882111968367 2.61515727755522e-20 NA NA NA hsa-miR-96-5p BICD1 3.24596558166606 1.92296159041707e-98 -0.228713712943127 0.0552012919299171 TargetScan -0.115566035260864 8.47125984404932e-07 NA NA NA hsa-miR-335-5p BIK -2.61355235628987 2.6462884165886e-51 2.21581662168298 1.28177157925645e-35 miRNAWalker2_validate -0.235221901156257 5.61008877022668e-12 NA NA NA hsa-miR-375 BIRC3 2.09893673049766 1.68351780396203e-16 -0.218777544640556 0.161832422376856 miRNAWalker2_validate -0.126687363073563 5.66067780629141e-10 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-miR-335-5p BIRC5 -2.61355235628987 2.6462884165886e-51 4.09209095153705 1.93163288942756e-86 miRNAWalker2_validate;MirTarget -0.48525735260279 1.19254878794e-31 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-429 BIVM 2.84108892259147 3.88520896426515e-64 -0.67208916676929 1.82454274937285e-13 miRanda -0.103218582792843 2.99879646701964e-09 NA NA NA hsa-miR-200c-3p BLCAP 2.07038651806183 6.84613386286599e-51 -0.61293600830262 7.0045347509599e-26 MirTarget -0.110128680305086 1.21146020661216e-15 NA NA NA hsa-miR-378a-5p BMF -2.43173551693523 1.44932837789175e-68 0.82561066472565 4.90625245205423e-24 mirMAP -0.115424910739389 9.0608295955092e-10 NA NA NA hsa-miR-335-5p BMP1 -2.61355235628987 2.6462884165886e-51 0.565301253063899 6.06878861078194e-08 miRNAWalker2_validate -0.115853017604082 2.21050930979131e-09 NA NA NA hsa-miR-429 BMP2 2.84108892259147 3.88520896426515e-64 -2.65857867772634 6.10527487782614e-50 miRNATAP -0.40826129557167 7.17935100433753e-32 NA NA NA hsa-miR-21-5p BMP2K 2.32007501846389 3.08394781855554e-137 -0.606665941487059 3.28263902417702e-08 mirMAP -0.199405442229406 5.64238989878735e-09 NA NA NA hsa-miR-21-5p BMP3 2.32007501846389 3.08394781855554e-137 -4.25413345982395 5.99456594222856e-52 MirTarget -1.0000719728894 1.66064978529976e-28 NA NA NA hsa-miR-429 BMP3 2.84108892259147 3.88520896426515e-64 -4.25413345982395 5.99456594222856e-52 miRNATAP -0.581017406361432 4.88754511496789e-26 NA NA NA hsa-miR-182-5p BMPER 2.36408084103818 2.60011457600281e-72 -3.39784052600183 1.58968003995364e-53 MirTarget -0.636605915547171 6.63141927381953e-32 NA NA NA hsa-miR-429 BMPER 2.84108892259147 3.88520896426515e-64 -3.39784052600183 1.58968003995364e-53 PITA;miRanda -0.571282732793697 3.89097101330464e-41 NA NA NA hsa-miR-200b-3p BMPR2 2.11744072703209 1.66710572104191e-43 -0.619963448559116 4.34614935044474e-16 mirMAP -0.121047661495268 8.73119456445721e-14 NA NA NA hsa-miR-200c-3p BMPR2 2.07038651806183 6.84613386286599e-51 -0.619963448559116 4.34614935044474e-16 mirMAP -0.13697648800764 1.55247615315968e-14 NA NA NA hsa-miR-21-5p BMPR2 2.32007501846389 3.08394781855554e-137 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRTarBase;MirTarget -0.217097837256464 4.31156278024056e-20 NA NA NA hsa-miR-429 BMPR2 2.84108892259147 3.88520896426515e-64 -0.619963448559116 4.34614935044474e-16 mirMAP;miRNATAP -0.12305207734683 1.41517075947211e-17 NA NA NA hsa-miR-141-3p BNC2 2.99777540204168 1.26370498493024e-78 -0.776172590713737 2.35134421190691e-07 TargetScan -0.386175050807488 1.09867494793985e-43 NA NA NA hsa-miR-182-5p BNC2 2.36408084103818 2.60011457600281e-72 -0.776172590713737 2.35134421190691e-07 MirTarget;miRNATAP -0.25376106046466 9.82533308031192e-13 NA NA NA hsa-miR-183-5p BNC2 2.95681814393872 1.09965777344285e-92 -0.776172590713737 2.35134421190691e-07 miRNATAP -0.247352006146579 3.07938845458325e-15 NA NA NA hsa-miR-200b-3p BNC2 2.11744072703209 1.66710572104191e-43 -0.776172590713737 2.35134421190691e-07 MirTarget;TargetScan -0.364379236825585 3.65519345520506e-32 NA NA NA hsa-miR-200c-3p BNC2 2.07038651806183 6.84613386286599e-51 -0.776172590713737 2.35134421190691e-07 MirTarget -0.45901128056021 8.37829403854513e-43 NA NA NA hsa-miR-429 BNC2 2.84108892259147 3.88520896426515e-64 -0.776172590713737 2.35134421190691e-07 MirTarget;PITA;miRNATAP -0.297574366374385 8.13153099516021e-27 NA NA NA hsa-miR-96-5p BNC2 3.24596558166606 1.92296159041707e-98 -0.776172590713737 2.35134421190691e-07 TargetScan;miRNATAP -0.291752042413404 1.14942152160866e-23 NA NA NA hsa-miR-200b-3p BNIP2 2.11744072703209 1.66710572104191e-43 -0.80045076092255 4.23218754614542e-44 mirMAP -0.128386639673051 8.65540392356891e-25 NA NA NA hsa-miR-200c-3p BNIP2 2.07038651806183 6.84613386286599e-51 -0.80045076092255 4.23218754614542e-44 mirMAP -0.139960678206022 2.2965922170214e-24 NA NA NA hsa-miR-429 BNIP2 2.84108892259147 3.88520896426515e-64 -0.80045076092255 4.23218754614542e-44 mirMAP -0.112423004186144 7.62909283886614e-24 NA NA NA hsa-miR-183-5p BNIP3L 2.95681814393872 1.09965777344285e-92 -0.807418308640388 7.6695644248469e-24 MirTarget;miRNATAP -0.11426884798308 2.98017153308376e-11 NA NA NA hsa-miR-139-5p BNIPL -3.25846663863766 2.62018989415003e-112 1.20558087435999 3.09174462035319e-07 miRanda -0.108976725830954 0.025783348206094 NA NA NA hsa-miR-21-5p BOC 2.32007501846389 3.08394781855554e-137 -2.01843772991364 1.30246973101e-41 miRNAWalker2_validate -0.369378666460681 2.09992979719832e-14 NA NA NA hsa-miR-335-5p BOLA1 -2.61355235628987 2.6462884165886e-51 0.931318167753238 1.12015814569067e-21 MirTarget -0.118831391005412 9.78648480166961e-11 NA NA NA hsa-miR-486-5p BPNT1 -3.87258704301474 1.22658629378451e-80 0.787267215950906 5.47382282270133e-35 miRanda -0.105213143620559 6.04538169829029e-27 NA NA NA hsa-miR-144-5p BRI3BP -2.75914786146772 1.55794225315972e-50 1.20991509022595 2.30055060920513e-36 mirMAP -0.101603442443673 4.89906825876302e-09 NA NA NA hsa-miR-335-5p BRI3BP -2.61355235628987 2.6462884165886e-51 1.20991509022595 2.30055060920513e-36 mirMAP -0.159130635930455 3.37295890581925e-18 NA NA NA hsa-miR-486-5p BRI3BP -3.87258704301474 1.22658629378451e-80 1.20991509022595 2.30055060920513e-36 miRanda -0.104950317586497 3.41890235565587e-12 NA NA NA hsa-miR-378a-5p BRIP1 -2.43173551693523 1.44932837789175e-68 1.71677604502193 1.03220238144271e-21 miRNAWalker2_validate -0.127608101280443 0.00218699364125903 NA NA NA hsa-miR-182-5p BRMS1L 2.36408084103818 2.60011457600281e-72 -0.44199060027101 1.97997757954059e-13 MirTarget -0.100729272258928 2.10668868832752e-12 NA NA NA hsa-miR-486-5p BRSK1 -3.87258704301474 1.22658629378451e-80 1.43164024575634 9.18738364084366e-17 miRNATAP -0.162475655375017 7.97089049759183e-10 NA NA NA hsa-miR-429 BTAF1 2.84108892259147 3.88520896426515e-64 -0.78524039093821 6.14908016516797e-20 miRNATAP -0.106139473835189 1.18702162387958e-10 NA NA NA hsa-miR-182-5p BTBD11 2.36408084103818 2.60011457600281e-72 -1.51124268311417 1.35866630468674e-19 miRNATAP -0.274770813040437 8.57035110699401e-12 NA NA NA hsa-miR-183-5p BTBD11 2.95681814393872 1.09965777344285e-92 -1.51124268311417 1.35866630468674e-19 miRNATAP -0.287577154337422 4.3959892508545e-16 NA NA NA hsa-miR-429 BTBD11 2.84108892259147 3.88520896426515e-64 -1.51124268311417 1.35866630468674e-19 PITA;miRanda -0.248055952825207 6.84840136550102e-15 NA NA NA hsa-miR-21-5p BTBD3 2.32007501846389 3.08394781855554e-137 -0.365459214596853 5.23777567818811e-06 miRNAWalker2_validate;miRNATAP -0.133205941815074 9.42767603850498e-08 NA NA NA hsa-miR-21-5p BTBD7 2.32007501846389 3.08394781855554e-137 -0.653337440975355 2.62585942395581e-21 miRNAWalker2_validate -0.23946894228304 1.88953118249278e-29 NA NA NA hsa-miR-378a-5p BTBD9 -2.43173551693523 1.44932837789175e-68 0.121859602264633 0.0318861937223601 mirMAP -0.119233362196721 1.66801877204072e-21 NA NA NA hsa-miR-183-5p BTG1 2.95681814393872 1.09965777344285e-92 -0.523621251458791 2.1013192824905e-11 miRNATAP -0.129195879485805 3.23654646001695e-15 NA NA NA hsa-miR-21-5p BTG2 2.32007501846389 3.08394781855554e-137 -0.809620825866558 5.59677057319634e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.271889515348514 4.86541229128609e-09 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2 tumorigenesis gastric cancer hsa-miR-182-5p BTLA 2.36408084103818 2.60011457600281e-72 -0.180221510261523 0.413783833401845 MirTarget -0.254100206107608 1.17080965074226e-06 NA NA NA hsa-miR-107 BTRC 0.678998026350662 2.56224148930538e-16 0.120536048906525 0.159286798668058 MirTarget;miRanda;miRNATAP -0.176399193835294 3.95816507165993e-07 NA NA NA hsa-miR-130a-3p BTRC -1.15024914519431 6.51290317952496e-19 0.120536048906525 0.159286798668058 mirMAP -0.123950670209092 1.81836770188752e-08 NA NA NA hsa-miR-130b-3p BTRC 1.38122163823846 1.00932179737836e-26 0.120536048906525 0.159286798668058 mirMAP -0.166208529900913 2.6200359050573e-14 NA NA NA hsa-miR-132-3p BTRC -0.0365213889238607 0.668598301088667 0.120536048906525 0.159286798668058 MirTarget -0.16624989082982 1.42128564671786e-06 NA NA NA hsa-miR-15a-5p BTRC 0.812445324157528 4.50263417099822e-20 0.120536048906525 0.159286798668058 miRNAWalker2_validate;MirTarget;miRNATAP -0.190986059010062 3.25059412787152e-09 NA NA NA hsa-miR-185-5p BTRC 0.482334746589337 3.68475879959415e-09 0.120536048906525 0.159286798668058 mirMAP -0.27817268481314 2.83790268646345e-15 NA NA NA hsa-miR-186-5p BTRC -0.426987301460247 1.04129380549315e-05 0.120536048906525 0.159286798668058 mirMAP -0.153390623021547 3.48923481425663e-07 NA NA NA hsa-miR-212-3p BTRC 0.24081906669865 0.0571447155653209 0.120536048906525 0.159286798668058 MirTarget -0.173369799058415 8.47662747538148e-14 NA NA NA hsa-miR-22-5p BTRC 0.238328801322329 0.0377496760295305 0.120536048906525 0.159286798668058 miRNATAP -0.169967299467369 1.97069244765403e-11 NA NA NA hsa-miR-224-5p BTRC -2.22249420723892 1.07787949391113e-18 0.120536048906525 0.159286798668058 MirTarget -0.132498017840424 7.27857382043359e-34 NA NA NA hsa-miR-28-5p BTRC -0.14267073663385 0.0497619246260571 0.120536048906525 0.159286798668058 miRanda -0.245382923565365 1.23962341723426e-09 NA NA NA hsa-miR-361-3p BTRC -0.0370446538644886 0.624902392829872 0.120536048906525 0.159286798668058 MirTarget;PITA;miRNATAP -0.232101959717311 2.15887515093051e-09 NA NA NA hsa-miR-505-3p BTRC -0.530462599544864 7.71645736541597e-05 0.120536048906525 0.159286798668058 MirTarget -0.19714346161221 2.15462077391573e-20 NA NA NA hsa-miR-576-5p BTRC 0.0649387707567879 0.588791966096287 0.120536048906525 0.159286798668058 mirMAP -0.106901631789694 1.17834154523049e-05 NA NA NA hsa-miR-92a-3p BTRC -0.342420481092807 0.000732275969501111 0.120536048906525 0.159286798668058 miRNAWalker2_validate -0.218742875572353 1.77336318401607e-14 NA NA NA hsa-miR-139-5p BUB1 -3.25846663863766 2.62018989415003e-112 3.58074914300466 1.00791550985226e-91 miRanda -0.676658906458606 4.07397826149591e-74 NA NA NA hsa-miR-486-5p BUB1B -3.87258704301474 1.22658629378451e-80 3.23445091135015 9.85826919015158e-87 miRanda -0.326934382418176 1.3721748065016e-34 NA NA NA hsa-miR-139-5p BUB3 -3.25846663863766 2.62018989415003e-112 0.935337217612312 2.05561051785776e-37 miRanda -0.187467052732184 2.23759413543203e-35 NA NA NA hsa-miR-141-3p BVES 2.99777540204168 1.26370498493024e-78 -1.62299717888388 6.51596614677981e-33 mirMAP -0.3200976190746 7.89312634207751e-34 NA NA NA hsa-miR-200a-3p BVES 2.55218480823434 2.96135446816238e-51 -1.62299717888388 6.51596614677981e-33 mirMAP -0.295934187886683 6.15942660034593e-30 NA NA NA hsa-miR-375 BVES 2.09893673049766 1.68351780396203e-16 -1.62299717888388 6.51596614677981e-33 miRNATAP -0.132466638472478 6.3312654314229e-13 NA NA NA hsa-miR-452-5p BZW1 -2.48486455572568 1.24430987974325e-33 0.480472230042582 9.92353430265346e-12 MirTarget;miRNATAP -0.111180268401706 1.30030158068662e-23 NA NA NA hsa-miR-429 C10orf105 2.84108892259147 3.88520896426515e-64 -1.37741869836931 5.7847382458008e-20 miRNATAP -0.25051495309785 2.05736601844243e-18 NA NA NA hsa-miR-141-3p C11orf21 2.99777540204168 1.26370498493024e-78 -0.329432320728833 0.0780147278787802 mirMAP -0.13539699924965 0.000189807986797707 NA NA NA hsa-miR-183-5p C14orf132 2.95681814393872 1.09965777344285e-92 -1.15546153208154 1.88099814327528e-11 mirMAP -0.204091305919345 2.18016335914033e-08 NA NA NA hsa-miR-429 C14orf28 2.84108892259147 3.88520896426515e-64 -0.847140768017533 2.01176828606549e-35 miRNATAP -0.131767215216318 9.4341279116392e-24 NA NA NA hsa-miR-375 C15orf41 2.09893673049766 1.68351780396203e-16 -0.393209738145398 7.08182497984387e-06 miRNATAP -0.131015171123404 8.34622298919854e-32 NA NA NA hsa-miR-182-5p C15orf52 2.36408084103818 2.60011457600281e-72 -0.988036151207465 5.03254487655622e-12 mirMAP -0.126430210516824 0.000246574743817192 NA NA NA hsa-miR-21-5p C16orf52 2.32007501846389 3.08394781855554e-137 -0.439770788571493 2.5380865851945e-12 miRNATAP -0.17489098935188 1.80280225638813e-19 NA NA NA hsa-miR-182-5p C17orf51 2.36408084103818 2.60011457600281e-72 -1.38118393054696 1.19626145693611e-32 mirMAP -0.372708294334291 2.54771847167986e-42 NA NA NA hsa-miR-200b-3p C17orf51 2.11744072703209 1.66710572104191e-43 -1.38118393054696 1.19626145693611e-32 mirMAP -0.312872287849088 2.31831204331372e-37 NA NA NA hsa-miR-200c-3p C17orf51 2.07038651806183 6.84613386286599e-51 -1.38118393054696 1.19626145693611e-32 mirMAP -0.364192605482146 3.68097874270194e-42 NA NA NA hsa-miR-21-3p C17orf51 2.17476065946878 5.15299442583591e-75 -1.38118393054696 1.19626145693611e-32 mirMAP -0.147300450957718 3.31560476006752e-06 NA NA NA hsa-miR-429 C17orf51 2.84108892259147 3.88520896426515e-64 -1.38118393054696 1.19626145693611e-32 mirMAP -0.23994235184365 2.60392510245253e-27 NA NA NA hsa-miR-429 C1QTNF3 2.84108892259147 3.88520896426515e-64 0.572828865640011 0.000569974537173078 miRanda -0.125667499923422 6.62238824877965e-05 NA NA NA hsa-miR-429 C1orf115 2.84108892259147 3.88520896426515e-64 -1.54554703444207 4.45055578351909e-25 miRNATAP -0.187658098714048 8.14093026837146e-11 NA NA NA hsa-miR-96-5p C1orf115 3.24596558166606 1.92296159041707e-98 -1.54554703444207 4.45055578351909e-25 mirMAP -0.162518234005216 7.87178997961229e-08 NA NA NA hsa-miR-224-5p C1orf21 -2.22249420723892 1.07787949391113e-18 -0.468027970401431 0.00105985509741778 mirMAP -0.131615319233814 2.72070911390545e-12 NA NA NA hsa-miR-452-5p C1orf21 -2.48486455572568 1.24430987974325e-33 -0.468027970401431 0.00105985509741778 mirMAP -0.130567596630495 9.17294610895604e-09 NA NA NA hsa-miR-21-5p C1orf226 2.32007501846389 3.08394781855554e-137 -0.372381264122664 0.0272316478618929 mirMAP -0.209671378953326 6.44200178894493e-05 NA NA NA hsa-miR-335-5p C2 -2.61355235628987 2.6462884165886e-51 0.519123555705141 9.32055606960356e-05 miRNAWalker2_validate -0.102859809818781 3.11336762650078e-05 NA NA NA hsa-miR-141-3p C20orf194 2.99777540204168 1.26370498493024e-78 -1.30628408327392 8.98863433785682e-65 TargetScan;mirMAP -0.240321639489277 4.31437364630982e-57 NA NA NA hsa-miR-182-5p C20orf194 2.36408084103818 2.60011457600281e-72 -1.30628408327392 8.98863433785682e-65 mirMAP;miRNATAP -0.180038165926416 1.75312031793662e-20 NA NA NA hsa-miR-200a-3p C20orf194 2.55218480823434 2.96135446816238e-51 -1.30628408327392 8.98863433785682e-65 mirMAP -0.174018111512723 8.13873240561337e-30 NA NA NA hsa-miR-429 C20orf194 2.84108892259147 3.88520896426515e-64 -1.30628408327392 8.98863433785682e-65 miRNATAP -0.186224741237005 8.97111921142176e-35 NA NA NA hsa-miR-96-5p C20orf194 3.24596558166606 1.92296159041707e-98 -1.30628408327392 8.98863433785682e-65 TargetScan;miRNATAP -0.194346493187954 9.27408062898381e-35 NA NA NA hsa-miR-429 C22orf39 2.84108892259147 3.88520896426515e-64 -0.762259108698806 1.10384633565497e-32 miRNATAP -0.132256472959505 2.31621297871398e-27 NA NA NA hsa-miR-141-5p C2CD2 2.38411349683216 4.56310582620282e-58 -1.51511551068723 4.33392668471649e-48 MirTarget -0.295505139441085 5.23162241981941e-39 NA NA NA hsa-miR-486-5p C2CD4A -3.87258704301474 1.22658629378451e-80 0.736693913335136 0.0306325990846303 miRanda -0.177898005096856 0.000587389131833398 NA NA NA hsa-miR-335-5p C2orf54 -2.61355235628987 2.6462884165886e-51 2.43675623129626 2.54280224408002e-11 mirMAP -0.47525536092945 2.55309412309323e-12 NA NA NA hsa-miR-182-5p C3orf58 2.36408084103818 2.60011457600281e-72 -1.12310185311628 1.37287955327128e-21 miRNATAP -0.265343871066578 3.46147817879981e-21 NA NA NA hsa-miR-96-5p C3orf58 3.24596558166606 1.92296159041707e-98 -1.12310185311628 1.37287955327128e-21 miRNATAP -0.195918397318204 6.27412735973692e-17 NA NA NA hsa-miR-200b-3p C4orf32 2.11744072703209 1.66710572104191e-43 -0.941241213607787 1.31431030094497e-11 TargetScan -0.10951191541219 0.00024076472896205 NA NA NA hsa-miR-429 C5 2.84108892259147 3.88520896426515e-64 -0.803364372130806 8.44778154112632e-12 miRanda -0.114845547394625 3.07416375822498e-07 NA NA NA hsa-miR-375 C7 2.09893673049766 1.68351780396203e-16 -3.45742684125147 4.60513107256491e-21 miRanda;miRNATAP -0.162163335989875 0.00108377995115516 NA NA NA hsa-miR-182-5p C9orf72 2.36408084103818 2.60011457600281e-72 -0.783195459064012 1.77321195010496e-22 miRNATAP -0.113855354574402 5.092149381869e-09 NA NA NA hsa-miR-145-5p CA12 -2.62703571936687 7.64402900188551e-88 1.1080341989271 2.19542324257114e-05 mirMAP -0.176650683962353 0.00373847067408946 NA NA NA hsa-miR-429 CA3 2.84108892259147 3.88520896426515e-64 -4.76115455759417 5.60189517408586e-68 miRanda -0.522664079645288 2.36415537151828e-21 NA NA NA hsa-miR-429 CA5B 2.84108892259147 3.88520896426515e-64 -0.806755426838697 5.90134969972477e-19 miRanda;miRNATAP -0.14804280254044 8.08469043364082e-18 NA NA NA hsa-miR-429 CABP1 2.84108892259147 3.88520896426515e-64 -2.26924417074475 3.72025686899639e-42 miRNATAP -0.328773527483947 3.31803323575523e-24 NA NA NA hsa-miR-10b-5p CABP7 -2.10996264627796 7.36811595736367e-72 1.17917915211123 1.26154510930854e-12 mirMAP -0.332588162501166 5.68694004259008e-14 NA NA NA hsa-miR-139-5p CABP7 -3.25846663863766 2.62018989415003e-112 1.17917915211123 1.26154510930854e-12 miRanda -0.238418414649197 3.45993081608738e-12 NA NA NA hsa-miR-139-5p CABYR -3.25846663863766 2.62018989415003e-112 0.970666039484062 4.92255845372636e-13 miRanda -0.174944748405703 3.048112709866e-10 NA NA NA hsa-miR-200b-3p CACHD1 2.11744072703209 1.66710572104191e-43 -2.56774598917352 6.13969823521877e-72 TargetScan -0.337489505775331 1.43695728531767e-25 NA NA NA hsa-miR-429 CACHD1 2.84108892259147 3.88520896426515e-64 -2.56774598917352 6.13969823521877e-72 miRanda;miRNATAP -0.347720519983662 3.1943984873722e-34 NA NA NA hsa-miR-335-5p CACNA1B -2.61355235628987 2.6462884165886e-51 1.04977639737129 0.000114751575534089 miRNAWalker2_validate -0.167340866920994 0.000966752678690897 NA NA NA hsa-miR-200b-3p CACNA1C 2.11744072703209 1.66710572104191e-43 -0.825897678032819 4.27711725647878e-10 MirTarget;TargetScan -0.118126560258071 2.93890482056991e-05 NA NA NA hsa-miR-200c-3p CACNA1C 2.07038651806183 6.84613386286599e-51 -0.825897678032819 4.27711725647878e-10 MirTarget -0.177083982550756 1.05519360943015e-08 NA NA NA hsa-miR-429 CACNA1C 2.84108892259147 3.88520896426515e-64 -0.825897678032819 4.27711725647878e-10 MirTarget;PITA;miRanda;miRNATAP -0.158582393705344 2.56283711392604e-10 NA NA NA hsa-miR-96-5p CACNA1C 3.24596558166606 1.92296159041707e-98 -0.825897678032819 4.27711725647878e-10 MirTarget;TargetScan -0.16303248428651 4.80189450318412e-10 NA NA NA hsa-miR-145-5p CACNA1D -2.62703571936687 7.64402900188551e-88 1.29741717389352 5.48962840197304e-09 MirTarget;miRNATAP -0.169999006636138 0.00110885711768601 NA NA NA hsa-miR-96-5p CACNA1G 3.24596558166606 1.92296159041707e-98 -1.37568574377156 8.21308100897495e-10 TargetScan -0.431573427571995 4.13927647444552e-23 NA NA NA hsa-miR-141-3p CACNA2D1 2.99777540204168 1.26370498493024e-78 -3.13664353232148 8.51761818806015e-30 TargetScan -0.686981792019036 4.96940699743537e-38 NA NA NA hsa-miR-182-5p CACNA2D1 2.36408084103818 2.60011457600281e-72 -3.13664353232148 8.51761818806015e-30 miRNATAP -0.50122250597948 1.08020836557635e-13 NA NA NA hsa-miR-200b-3p CACNA2D1 2.11744072703209 1.66710572104191e-43 -3.13664353232148 8.51761818806015e-30 TargetScan -0.611285006989797 4.91380566101455e-25 NA NA NA hsa-miR-21-3p CACNA2D1 2.17476065946878 5.15299442583591e-75 -3.13664353232148 8.51761818806015e-30 mirMAP -0.425146647588401 1.45632639267905e-08 NA NA NA hsa-miR-96-5p CACNA2D1 3.24596558166606 1.92296159041707e-98 -3.13664353232148 8.51761818806015e-30 TargetScan;miRNATAP -0.587322748547346 1.33430099096002e-26 NA NA NA hsa-miR-429 CACNA2D3 2.84108892259147 3.88520896426515e-64 -0.594228318106601 0.00283872336537229 miRanda -0.172954610693339 4.31660482370429e-06 NA NA NA hsa-miR-429 CACNA2D4 2.84108892259147 3.88520896426515e-64 -0.487016307401622 1.87890750129587e-06 miRanda -0.116251771905887 1.68988958973746e-09 NA NA NA hsa-miR-335-5p CACNB3 -2.61355235628987 2.6462884165886e-51 1.46776600105089 1.46068987438074e-50 miRNAWalker2_validate -0.149702354514404 4.8882086502149e-15 NA NA NA hsa-miR-182-5p CACNB4 2.36408084103818 2.60011457600281e-72 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.160616053986078 7.11532513599297e-05 NA NA NA hsa-miR-183-5p CACNB4 2.95681814393872 1.09965777344285e-92 -1.55153828539339 8.66363537242103e-21 miRNATAP -0.239521601010266 1.40564551535371e-11 NA NA NA hsa-miR-429 CACNB4 2.84108892259147 3.88520896426515e-64 -1.55153828539339 8.66363537242103e-21 PITA;miRanda;miRNATAP -0.218364425149989 7.04069249222511e-12 NA NA NA hsa-miR-96-5p CACNB4 3.24596558166606 1.92296159041707e-98 -1.55153828539339 8.66363537242103e-21 TargetScan;miRNATAP -0.22030994152209 3.5598621080731e-11 NA NA NA hsa-miR-335-5p CACNG1 -2.61355235628987 2.6462884165886e-51 1.8711950939276 2.7149648014842e-09 miRNAWalker2_validate -0.132107788631902 0.0253272123789604 NA NA NA hsa-miR-335-5p CACNG4 -2.61355235628987 2.6462884165886e-51 2.21159891256783 3.76360584804154e-13 miRNAWalker2_validate;mirMAP -0.148521805566539 0.00971039985566161 NA NA NA hsa-miR-195-3p CACYBP -1.49582726452416 6.53261924105147e-40 0.792711685346167 1.34889809750836e-27 mirMAP -0.232768845045075 1.84734186920475e-28 NA NA NA hsa-miR-30a-3p CACYBP -1.08956435286856 1.10750674569595e-12 0.792711685346167 1.34889809750836e-27 MirTarget -0.119257746654091 3.45819271489493e-13 NA NA NA hsa-miR-30e-3p CACYBP -0.708952170420973 1.05866470714978e-22 0.792711685346167 1.34889809750836e-27 MirTarget -0.156128522151445 7.85773396828642e-06 NA NA NA hsa-miR-141-3p CADM2 2.99777540204168 1.26370498493024e-78 -2.4039007121495 1.66875358505835e-18 TargetScan;miRNATAP -0.404306118506428 4.80251553001281e-14 NA NA NA hsa-miR-182-5p CADM2 2.36408084103818 2.60011457600281e-72 -2.4039007121495 1.66875358505835e-18 MirTarget;mirMAP;miRNATAP -0.131573844835926 0.0488336166444049 NA NA NA hsa-miR-196a-5p CADM2 2.33423717464504 3.646557504928e-18 -2.4039007121495 1.66875358505835e-18 miRNATAP -0.180834703989912 1.9075754339237e-07 NA NA NA hsa-miR-200a-3p CADM2 2.55218480823434 2.96135446816238e-51 -2.4039007121495 1.66875358505835e-18 miRNATAP -0.252610300188707 2.01474761554171e-06 NA NA NA hsa-miR-21-5p CADM2 2.32007501846389 3.08394781855554e-137 -2.4039007121495 1.66875358505835e-18 mirMAP;miRNATAP -0.852795114758381 9.87753191981313e-24 NA NA NA hsa-miR-224-5p CADM2 -2.22249420723892 1.07787949391113e-18 -2.4039007121495 1.66875358505835e-18 mirMAP -0.163386837056061 1.0673293905645e-05 NA NA NA hsa-miR-429 CADM2 2.84108892259147 3.88520896426515e-64 -2.4039007121495 1.66875358505835e-18 miRanda;miRNATAP -0.296852664685655 1.72255323078508e-08 NA NA NA hsa-miR-452-5p CADM2 -2.48486455572568 1.24430987974325e-33 -2.4039007121495 1.66875358505835e-18 MirTarget -0.127988416533862 0.00422312676275801 NA NA NA hsa-miR-96-5p CADM2 3.24596558166606 1.92296159041707e-98 -2.4039007121495 1.66875358505835e-18 TargetScan;miRNATAP -0.2712345895769 8.47704483579416e-07 NA NA NA hsa-miR-141-3p CALCR 2.99777540204168 1.26370498493024e-78 -2.09521121092609 1.65401230978274e-27 MirTarget;TargetScan;miRNATAP -0.362458535071316 9.4058665350797e-22 NA NA NA hsa-miR-141-5p CALCR 2.38411349683216 4.56310582620282e-58 -2.09521121092609 1.65401230978274e-27 MirTarget -0.349875783221452 8.98172889415331e-17 NA NA NA hsa-miR-200a-3p CALCR 2.55218480823434 2.96135446816238e-51 -2.09521121092609 1.65401230978274e-27 MirTarget;miRNATAP -0.272238498570481 4.07601585086017e-13 NA NA NA hsa-miR-200b-3p CALCR 2.11744072703209 1.66710572104191e-43 -2.09521121092609 1.65401230978274e-27 MirTarget -0.276220054174993 4.13927686220689e-11 NA NA NA hsa-miR-200c-3p CALCR 2.07038651806183 6.84613386286599e-51 -2.09521121092609 1.65401230978274e-27 MirTarget -0.355606068072519 8.24857300495474e-15 NA NA NA hsa-miR-429 CALCR 2.84108892259147 3.88520896426515e-64 -2.09521121092609 1.65401230978274e-27 miRanda;miRNATAP -0.325142760089129 1.56650592476255e-18 NA NA NA hsa-miR-96-5p CALCR 3.24596558166606 1.92296159041707e-98 -2.09521121092609 1.65401230978274e-27 TargetScan -0.352217632111024 6.63712514381243e-20 NA NA NA hsa-miR-96-5p CALCRL 3.24596558166606 1.92296159041707e-98 -0.95494285130872 5.4649336343346e-14 MirTarget -0.196309982579235 5.26510204745013e-15 NA NA NA hsa-miR-182-5p CALD1 2.36408084103818 2.60011457600281e-72 -0.977982331069182 1.18727276687937e-21 MirTarget -0.254724657836353 8.91506681099781e-26 NA NA NA hsa-miR-21-5p CALD1 2.32007501846389 3.08394781855554e-137 -0.977982331069182 1.18727276687937e-21 miRNAWalker2_validate;MirTarget -0.114490339096093 0.000456521184701928 NA NA NA hsa-miR-429 CALD1 2.84108892259147 3.88520896426515e-64 -0.977982331069182 1.18727276687937e-21 miRanda -0.194144719434878 1.04456800638229e-23 NA NA NA hsa-miR-335-5p CALML5 -2.61355235628987 2.6462884165886e-51 1.22220772204633 0.00521721088309991 miRNAWalker2_validate -0.523338205356834 8.47288304296098e-11 NA NA NA hsa-miR-141-3p CALN1 2.99777540204168 1.26370498493024e-78 -2.70813184176793 2.87746517163719e-26 mirMAP -0.605072642812346 8.51135502529506e-35 NA NA NA hsa-miR-141-5p CALN1 2.38411349683216 4.56310582620282e-58 -2.70813184176793 2.87746517163719e-26 mirMAP -0.48223282386388 3.85463896919858e-18 NA NA NA hsa-miR-182-5p CALN1 2.36408084103818 2.60011457600281e-72 -2.70813184176793 2.87746517163719e-26 mirMAP -0.499784593445621 6.09641646587083e-16 NA NA NA hsa-miR-183-5p CALN1 2.95681814393872 1.09965777344285e-92 -2.70813184176793 2.87746517163719e-26 mirMAP;miRNATAP -0.587650144822822 9.07219807284364e-28 NA NA NA hsa-miR-21-5p CALN1 2.32007501846389 3.08394781855554e-137 -2.70813184176793 2.87746517163719e-26 mirMAP -0.499815411366113 8.63108549614904e-10 NA NA NA hsa-miR-429 CALN1 2.84108892259147 3.88520896426515e-64 -2.70813184176793 2.87746517163719e-26 miRNATAP -0.513759881115586 2.90039892306723e-26 NA NA NA hsa-miR-96-5p CALN1 3.24596558166606 1.92296159041707e-98 -2.70813184176793 2.87746517163719e-26 mirMAP -0.588508402582586 1.01487561985329e-31 NA NA NA hsa-miR-141-5p CAMK1 2.38411349683216 4.56310582620282e-58 -1.07273829861666 5.97552550359685e-32 MirTarget -0.278693452298085 9.11967034652912e-48 NA NA NA hsa-miR-200c-3p CAMK1D 2.07038651806183 6.84613386286599e-51 0.17033798810489 0.172578200817693 mirMAP -0.10370164232462 0.000360827289623906 NA NA NA hsa-miR-125a-5p CAMK2A -0.635694700253268 3.6703235721638e-11 0.980053374553274 1.40873134154558e-08 mirMAP -0.306152492531801 6.24694931450318e-07 NA NA NA hsa-miR-19b-1-5p CAMK2A 0.647704962003062 3.07687667945597e-07 0.980053374553274 1.40873134154558e-08 mirMAP -0.127806056998247 0.00655388531126769 NA NA NA hsa-miR-25-3p CAMK2A -0.00546790775985073 0.944061771389468 0.980053374553274 1.40873134154558e-08 MirTarget -0.21042761959986 0.00657433659879039 NA NA NA hsa-miR-26a-5p CAMK2A -0.481180084102235 1.82368246174758e-10 0.980053374553274 1.40873134154558e-08 miRNATAP -0.226702776972991 0.00412036831502982 NA NA NA hsa-miR-26b-5p CAMK2A -0.331527896896866 0.000551258576575092 0.980053374553274 1.40873134154558e-08 miRNATAP -0.201669642863581 0.00121808822640433 NA NA NA hsa-miR-30a-5p CAMK2A -0.392489994825279 0.00954894667761676 0.980053374553274 1.40873134154558e-08 mirMAP -0.208560410066033 1.02470554341187e-07 NA NA NA hsa-miR-30b-5p CAMK2A -0.46540603860146 2.4709940429591e-05 0.980053374553274 1.40873134154558e-08 mirMAP -0.299993290244448 2.31458535837861e-08 NA NA NA hsa-miR-30c-5p CAMK2A -0.393222674580066 8.06961465717306e-05 0.980053374553274 1.40873134154558e-08 mirMAP -0.343105483733946 8.04306460208188e-09 NA NA NA hsa-miR-30d-5p CAMK2A -0.247082219011045 0.00406717930063148 0.980053374553274 1.40873134154558e-08 mirMAP -0.500830199163001 3.66036488570952e-13 NA NA NA hsa-miR-30e-5p CAMK2A 0.293491764699475 0.000372291967271834 0.980053374553274 1.40873134154558e-08 mirMAP -0.34551062842794 1.86639620197896e-06 NA NA NA hsa-miR-331-3p CAMK2A 0.74441480542886 1.17071235477799e-07 0.980053374553274 1.40873134154558e-08 MirTarget -0.108046315570154 0.0105695968923695 NA NA NA hsa-miR-335-5p CAMK2A -2.61355235628987 2.6462884165886e-51 0.980053374553274 1.40873134154558e-08 mirMAP -0.159866461109795 6.97412013828671e-07 NA NA NA hsa-miR-338-3p CAMK2A 0.0799903526884966 0.575137668326679 0.980053374553274 1.40873134154558e-08 miRNATAP -0.209986268079133 4.80281615465648e-07 NA NA NA hsa-miR-361-3p CAMK2A -0.0370446538644886 0.624902392829872 0.980053374553274 1.40873134154558e-08 mirMAP -0.326015515432829 4.08216101266611e-05 NA NA NA hsa-miR-625-5p CAMK2A 0.728939236913178 5.97591217674307e-08 0.980053374553274 1.40873134154558e-08 mirMAP -0.179712426290662 7.7289889783295e-05 NA NA NA hsa-miR-7-1-3p CAMK2A 0.686579567507582 1.20731554448806e-07 0.980053374553274 1.40873134154558e-08 MirTarget -0.262098249281639 8.03032900468887e-09 NA NA NA hsa-miR-92a-3p CAMK2A -0.342420481092807 0.000732275969501111 0.980053374553274 1.40873134154558e-08 MirTarget -0.281889994119232 1.60654390365786e-06 NA NA NA hsa-miR-1271-5p CAMK2B -1.08290983583835 3.85149976357318e-12 -0.00506231354389119 0.984198517683776 mirMAP -0.199793610717617 0.000348914268332107 NA NA NA hsa-miR-150-5p CAMK2B -0.832049526091211 3.45299201139224e-05 -0.00506231354389119 0.984198517683776 mirMAP -0.198156634053672 4.48723158474492e-06 NA NA NA hsa-miR-186-5p CAMK2B -0.426987301460247 1.04129380549315e-05 -0.00506231354389119 0.984198517683776 miRNAWalker2_validate;miRNATAP -0.420009924398004 3.08262880687716e-06 NA NA NA hsa-miR-18a-5p CAMK2B 0.969066793715868 1.69069796425892e-08 -0.00506231354389119 0.984198517683776 mirMAP -0.272652665944852 5.85107409807785e-08 NA NA NA hsa-miR-193a-3p CAMK2B 0.310617999804917 0.00477640270974957 -0.00506231354389119 0.984198517683776 mirMAP -0.169652643632819 0.0334097160642525 NA NA NA hsa-miR-2355-5p CAMK2B -0.221733044425126 0.0231054202524677 -0.00506231354389119 0.984198517683776 mirMAP -0.534987844428681 2.11741953815093e-09 NA NA NA hsa-miR-24-3p CAMK2B -0.120123317289941 0.21432376743243 -0.00506231354389119 0.984198517683776 MirTarget -0.668590574540919 9.25330039258928e-14 NA NA NA hsa-miR-362-5p CAMK2B -0.248676340901797 0.0726089851456282 -0.00506231354389119 0.984198517683776 miRNATAP -0.373141196834054 2.76360587755669e-09 NA NA NA hsa-miR-589-3p CAMK2B 0.0263457630961427 0.866577983997705 -0.00506231354389119 0.984198517683776 MirTarget -0.282678683570449 6.81881545878125e-07 NA NA NA hsa-miR-590-3p CAMK2B 1.27438512890514 1.03164723481469e-23 -0.00506231354389119 0.984198517683776 miRanda -0.261169954511755 0.000193900443755323 NA NA NA hsa-miR-628-5p CAMK2B 0.107482129280898 0.569748271582925 -0.00506231354389119 0.984198517683776 miRNATAP -0.162840590843991 0.000430398534263797 NA NA NA hsa-miR-200b-3p CAMK2D 2.11744072703209 1.66710572104191e-43 -0.878893243229353 8.81421222940348e-16 TargetScan;mirMAP -0.176484130686564 3.1915455415824e-14 NA NA NA hsa-miR-342-3p CAMK2D 1.21944481975657 6.81914373001202e-19 -0.878893243229353 8.81421222940348e-16 miRanda -0.127822107335849 2.3223826328776e-06 NA NA NA hsa-miR-429 CAMK2D 2.84108892259147 3.88520896426515e-64 -0.878893243229353 8.81421222940348e-16 mirMAP;miRNATAP -0.142005527474459 9.28571715889098e-12 NA NA NA hsa-miR-139-5p CAPG -3.25846663863766 2.62018989415003e-112 1.28776877951361 5.17086999721969e-32 miRanda -0.225502427289996 4.59130102006183e-23 NA NA NA hsa-miR-335-5p CAPN13 -2.61355235628987 2.6462884165886e-51 2.15795656340211 5.27926331327954e-12 miRNAWalker2_validate -0.162254010559737 0.00588142805527246 NA NA NA hsa-miR-429 CAPN6 2.84108892259147 3.88520896426515e-64 -3.62270638284474 1.23690757569109e-25 miRanda -0.416985047131177 4.99303572048637e-10 NA NA NA hsa-miR-429 CAPS2 2.84108892259147 3.88520896426515e-64 -1.16117870356141 4.68975831009494e-17 miRanda -0.135644744522795 3.33645971253981e-07 NA NA NA hsa-miR-141-5p CARD8 2.38411349683216 4.56310582620282e-58 -0.683006969243752 3.13860670906734e-29 MirTarget -0.129263145325043 9.80805691519491e-23 NA NA NA hsa-miR-452-5p CASC1 -2.48486455572568 1.24430987974325e-33 0.0712048372619339 0.728770893228244 MirTarget -0.445159797294547 6.93699779838269e-47 NA NA NA hsa-miR-21-5p CASC4 2.32007501846389 3.08394781855554e-137 -0.145612030347357 0.0429222652102424 miRNATAP -0.100117929548781 7.20011977519743e-06 NA NA NA hsa-miR-452-5p CASD1 -2.48486455572568 1.24430987974325e-33 -0.0659140314892692 0.571307043693956 MirTarget;miRNATAP -0.164718496792201 1.33308009021733e-19 NA NA NA hsa-miR-429 CASP1 2.84108892259147 3.88520896426515e-64 -0.825673600036105 2.80392417168398e-13 miRanda -0.113209819501878 1.59355255428101e-07 NA NA NA hsa-miR-200b-3p CASP10 2.11744072703209 1.66710572104191e-43 -1.06975607492518 1.19238028683847e-21 mirMAP -0.239445518155442 5.07791301456485e-24 NA NA NA hsa-miR-200c-3p CASP10 2.07038651806183 6.84613386286599e-51 -1.06975607492518 1.19238028683847e-21 mirMAP -0.273509969637675 6.53447298083599e-26 NA NA NA hsa-miR-21-5p CASP10 2.32007501846389 3.08394781855554e-137 -1.06975607492518 1.19238028683847e-21 mirMAP -0.182489722562965 2.9340743714182e-07 NA NA NA hsa-miR-429 CASP10 2.84108892259147 3.88520896426515e-64 -1.06975607492518 1.19238028683847e-21 mirMAP;miRNATAP -0.212886532614725 8.1773549392356e-24 NA NA NA hsa-miR-335-5p CASP14 -2.61355235628987 2.6462884165886e-51 2.0237609344078 2.65754561483005e-06 miRNAWalker2_validate -0.482853714698218 1.48881740970349e-09 NA NA NA hsa-miR-139-5p CASP3 -3.25846663863766 2.62018989415003e-112 0.666045797044402 6.39452182888629e-31 miRanda -0.133754697836399 1.82907069570434e-29 NA NA NA hsa-miR-429 CASQ2 2.84108892259147 3.88520896426515e-64 -3.49076428783702 2.37833322714261e-52 miRanda;miRNATAP -0.573775770264451 2.20359262060467e-38 NA NA NA hsa-miR-429 CAST 2.84108892259147 3.88520896426515e-64 -0.604908183673602 3.47308426442437e-18 miRanda -0.101241642446859 2.06425406451768e-14 NA NA NA hsa-miR-145-5p CASZ1 -2.62703571936687 7.64402900188551e-88 0.650698025577658 4.38286118706725e-10 miRNATAP -0.182104865024767 4.34115005275873e-14 NA NA NA hsa-miR-335-5p CATSPERB -2.61355235628987 2.6462884165886e-51 0.365108199150713 0.124707698788832 miRNAWalker2_validate -0.10129624189199 0.0219650378599093 NA NA NA hsa-miR-96-5p CAV1 3.24596558166606 1.92296159041707e-98 -3.35468478136284 1.45542787428009e-122 MirTarget;miRNATAP -0.586335469642356 2.11472408958771e-88 NA NA NA hsa-miR-429 CAV2 2.84108892259147 3.88520896426515e-64 -2.9505406301122 3.47336381205899e-107 miRNATAP -0.4328268507362 1.75501596123592e-57 NA NA NA hsa-miR-141-3p CBL 2.99777540204168 1.26370498493024e-78 -0.680370172816626 1.00788843412567e-17 MirTarget;TargetScan;mirMAP -0.115106125372554 1.1738554188593e-13 NA NA NA hsa-miR-200a-3p CBL 2.55218480823434 2.96135446816238e-51 -0.680370172816626 1.00788843412567e-17 MirTarget;mirMAP -0.106984119943656 2.26578579492675e-12 NA NA NA hsa-miR-200b-3p CBL 2.11744072703209 1.66710572104191e-43 -0.680370172816626 1.00788843412567e-17 MirTarget;TargetScan;mirMAP -0.118437584281099 2.87888645461771e-12 NA NA NA hsa-miR-200c-3p CBL 2.07038651806183 6.84613386286599e-51 -0.680370172816626 1.00788843412567e-17 MirTarget;mirMAP -0.136179026309206 2.63066757150576e-13 NA NA NA hsa-miR-21-5p CBL 2.32007501846389 3.08394781855554e-137 -0.680370172816626 1.00788843412567e-17 mirMAP -0.219435783158958 6.50717000138084e-19 NA NA NA hsa-miR-429 CBL 2.84108892259147 3.88520896426515e-64 -0.680370172816626 1.00788843412567e-17 MirTarget;PITA;mirMAP;miRNATAP -0.102338931677859 1.46624742956126e-11 NA NA NA hsa-miR-182-5p CBLN4 2.36408084103818 2.60011457600281e-72 -1.60647619160488 2.51946165192192e-13 miRNATAP -0.171430328204972 0.00123510961563502 NA NA NA hsa-miR-96-5p CBLN4 3.24596558166606 1.92296159041707e-98 -1.60647619160488 2.51946165192192e-13 TargetScan;miRNATAP -0.288585430509591 3.61164335388285e-11 NA NA NA hsa-miR-139-5p CBWD3 -3.25846663863766 2.62018989415003e-112 0.89217842214657 3.21894092107502e-14 miRanda -0.159508481261044 5.53807311454037e-11 NA NA NA hsa-miR-139-5p CBWD5 -3.25846663863766 2.62018989415003e-112 0.582660083591589 0.0563490576452449 miRanda -0.161229743270063 0.0103822983160488 NA NA NA hsa-miR-139-5p CBWD6 -3.25846663863766 2.62018989415003e-112 0.727716565803796 9.06709837259334e-12 miRanda -0.108936090151513 8.53510007203374e-07 NA NA NA hsa-miR-139-5p CBX1 -3.25846663863766 2.62018989415003e-112 0.589574617712646 8.71515936375866e-17 MirTarget;PITA;miRanda -0.170000207787324 1.11417627892683e-32 NA NA NA hsa-miR-335-5p CBX2 -2.61355235628987 2.6462884165886e-51 1.76715718001625 1.24916576306404e-18 mirMAP -0.226163977731481 2.1468075533608e-09 NA NA NA hsa-miR-139-5p CBX3 -3.25846663863766 2.62018989415003e-112 0.907308736735882 2.12940530919016e-49 miRanda -0.197006501970384 1.03843151818963e-55 NA NA NA hsa-miR-139-5p CBX4 -3.25846663863766 2.62018989415003e-112 1.72865346455953 9.45155771619618e-57 miRanda -0.218116569975022 1.85983060027382e-20 NA NA NA hsa-miR-335-5p CBX4 -2.61355235628987 2.6462884165886e-51 1.72865346455953 9.45155771619618e-57 miRNAWalker2_validate -0.182279448836808 1.20252063704949e-17 NA NA NA hsa-miR-182-5p CBX6 2.36408084103818 2.60011457600281e-72 -0.848777979845489 1.16822494339106e-11 miRNAWalker2_validate -0.145551828170232 1.27106211082478e-06 NA NA NA hsa-miR-183-5p CBX6 2.95681814393872 1.09965777344285e-92 -0.848777979845489 1.16822494339106e-11 mirMAP -0.178751169363178 1.27778107885654e-11 NA NA NA hsa-miR-96-5p CBX6 3.24596558166606 1.92296159041707e-98 -0.848777979845489 1.16822494339106e-11 MirTarget;TargetScan;miRNATAP -0.169142693730999 8.43436438634098e-12 NA NA NA hsa-miR-429 CCDC102B 2.84108892259147 3.88520896426515e-64 -0.317053154485668 0.00050728559700342 miRanda -0.122936276346308 6.16642814698739e-13 NA NA NA hsa-miR-378a-5p CCDC117 -2.43173551693523 1.44932837789175e-68 0.394319129781666 8.20647819684733e-05 MirTarget -0.1010166726577 8.26332291868663e-06 NA NA NA hsa-miR-139-5p CCDC120 -3.25846663863766 2.62018989415003e-112 0.741431950852856 7.31082351980185e-28 miRanda -0.130884364571861 1.46388772683196e-20 NA NA NA hsa-miR-21-5p CCDC121 2.32007501846389 3.08394781855554e-137 -0.594076223123026 3.52604595501097e-17 MirTarget -0.267949965844077 7.21203433284668e-36 NA NA NA hsa-miR-375 CCDC129 2.09893673049766 1.68351780396203e-16 -2.66028470423133 3.26429184948124e-17 miRanda -0.283502628080528 1.4321883306984e-11 NA NA NA hsa-miR-141-5p CCDC144A 2.38411349683216 4.56310582620282e-58 -1.81646873493086 7.7136972807591e-15 mirMAP -0.240553181144321 2.22955438642761e-06 NA NA NA hsa-miR-182-5p CCDC144A 2.36408084103818 2.60011457600281e-72 -1.81646873493086 7.7136972807591e-15 mirMAP -0.255967781365288 5.75068948088217e-06 NA NA NA hsa-miR-200a-5p CCDC144A 2.58844508672328 1.79650654234569e-56 -1.81646873493086 7.7136972807591e-15 mirMAP -0.197902787527072 1.90735005530936e-05 NA NA NA hsa-miR-429 CCDC144A 2.84108892259147 3.88520896426515e-64 -1.81646873493086 7.7136972807591e-15 miRanda -0.256436008492389 9.64823526323994e-09 NA NA NA hsa-miR-96-5p CCDC144A 3.24596558166606 1.92296159041707e-98 -1.81646873493086 7.7136972807591e-15 TargetScan -0.267434260472481 9.95004016713017e-09 NA NA NA hsa-miR-486-5p CCDC150 -3.87258704301474 1.22658629378451e-80 1.32921725146064 7.02666355283814e-18 miRanda -0.147671769407176 4.78860085502394e-10 NA NA NA hsa-miR-21-5p CCDC152 2.32007501846389 3.08394781855554e-137 -1.69381275709956 7.21109199063913e-45 mirMAP -0.361400293113989 1.29299622016233e-20 NA NA NA hsa-miR-21-3p CCDC158 2.17476065946878 5.15299442583591e-75 -2.54089046982657 1.05168982451251e-25 MirTarget -0.675117659708648 4.21360559031585e-26 NA NA NA hsa-miR-429 CCDC3 2.84108892259147 3.88520896426515e-64 -2.56146861194452 1.70607168073818e-76 miRanda -0.412533168910823 1.80359288537219e-52 NA NA NA hsa-miR-429 CCDC36 2.84108892259147 3.88520896426515e-64 -2.22974852242944 2.95796106794423e-53 miRanda -0.416799371032897 1.43217202559784e-51 NA NA NA hsa-miR-96-5p CCDC50 3.24596558166606 1.92296159041707e-98 -1.32804358916198 4.78202111890448e-88 TargetScan -0.236813788909525 1.17388744069516e-68 NA NA NA hsa-miR-429 CCDC69 2.84108892259147 3.88520896426515e-64 -2.75969921771176 1.40082443586356e-76 miRNATAP -0.43970857824767 2.79652079141861e-51 NA NA NA hsa-miR-141-3p CCDC80 2.99777540204168 1.26370498493024e-78 -1.64278449223908 9.9933942504804e-25 MirTarget;TargetScan -0.522371143852423 6.06710122719767e-71 NA NA NA hsa-miR-200a-3p CCDC80 2.55218480823434 2.96135446816238e-51 -1.64278449223908 9.9933942504804e-25 MirTarget -0.438329461131822 1.07849539272779e-49 NA NA NA hsa-miR-375 CCDC80 2.09893673049766 1.68351780396203e-16 -1.64278449223908 9.9933942504804e-25 miRanda -0.161951468589364 4.15709577186341e-14 NA NA NA hsa-miR-200b-3p CCDC82 2.11744072703209 1.66710572104191e-43 -1.56728659216967 4.7319112846567e-46 MirTarget;TargetScan -0.25354261389417 3.90235854787021e-26 NA NA NA hsa-miR-200c-3p CCDC82 2.07038651806183 6.84613386286599e-51 -1.56728659216967 4.7319112846567e-46 MirTarget -0.300076767632542 2.50086532254082e-30 NA NA NA hsa-miR-429 CCDC82 2.84108892259147 3.88520896426515e-64 -1.56728659216967 4.7319112846567e-46 MirTarget;miRanda;miRNATAP -0.215349351571278 1.17924405122625e-23 NA NA NA hsa-miR-429 CCDC85A 2.84108892259147 3.88520896426515e-64 -2.63514416883509 8.247493889982e-55 miRanda;miRNATAP -0.398332731863824 1.22343857360971e-33 NA NA NA hsa-miR-182-5p CCDC88A 2.36408084103818 2.60011457600281e-72 -0.84885267634896 1.71580832473087e-13 miRNATAP -0.266532487196678 9.21577202758871e-23 NA NA NA hsa-miR-200a-5p CCDC88A 2.58844508672328 1.79650654234569e-56 -0.84885267634896 1.71580832473087e-13 miRNATAP -0.131607239921564 6.28944007202353e-09 NA NA NA hsa-miR-375 CCDC88A 2.09893673049766 1.68351780396203e-16 -0.84885267634896 1.71580832473087e-13 miRNAWalker2_validate -0.14537006374533 4.10237275063293e-22 NA NA NA hsa-miR-429 CCDC88A 2.84108892259147 3.88520896426515e-64 -0.84885267634896 1.71580832473087e-13 miRNATAP -0.150159866280139 6.86453811391475e-12 NA NA NA hsa-miR-96-5p CCDC88A 3.24596558166606 1.92296159041707e-98 -0.84885267634896 1.71580832473087e-13 TargetScan;miRNATAP -0.196736773820817 3.86395156940362e-18 NA NA NA hsa-miR-21-3p CCDC93 2.17476065946878 5.15299442583591e-75 -0.595295486004899 6.20817626143531e-22 mirMAP -0.128938307059183 3.98575665360871e-15 NA NA NA hsa-miR-183-5p CCL18 2.95681814393872 1.09965777344285e-92 -0.913402395597833 0.00239064921427654 MirTarget -0.142843398225877 0.0246493051198968 NA NA NA hsa-miR-139-5p CCL20 -3.25846663863766 2.62018989415003e-112 1.72440828356672 2.38918369287704e-12 miRanda -0.37732418692412 9.17571692480006e-14 NA NA NA hsa-miR-335-5p CCL20 -2.61355235628987 2.6462884165886e-51 1.72440828356672 2.38918369287704e-12 miRNAWalker2_validate -0.262194126042181 1.20075089857546e-08 NA NA NA hsa-miR-429 CCL8 2.84108892259147 3.88520896426515e-64 -1.165293639494 2.0177181774187e-08 miRanda -0.163344204298901 3.6637060222626e-05 NA NA NA hsa-miR-486-5p CCNA2 -3.87258704301474 1.22658629378451e-80 2.73230807661792 1.49184563825378e-66 miRanda -0.262023712888287 7.82983896231198e-25 NA NA NA hsa-miR-139-5p CCNB1 -3.25846663863766 2.62018989415003e-112 2.41596782139125 1.64230288731479e-82 miRanda -0.48632264255974 6.28227602164649e-78 NA NA NA hsa-let-7g-5p CCND1 0.0200025784917734 0.791635298815256 0.789100261201456 1.48424202389562e-06 miRNATAP -0.162141133652712 0.0318118533604679 NA NA NA hsa-let-7i-5p CCND1 -0.333419326258177 3.56960810786801e-08 0.789100261201456 1.48424202389562e-06 miRNATAP -0.759700962013673 2.31065071397228e-16 NA NA NA hsa-miR-106a-5p CCND1 0.574594373206545 0.000145868284001732 0.789100261201456 1.48424202389562e-06 MirTarget;miRNATAP -0.174359830876255 2.65007775906387e-06 NA NA NA hsa-miR-106b-5p CCND1 1.22477789913175 2.31787213143326e-32 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258644062815507 8.24041501542474e-07 NA NA NA hsa-miR-142-3p CCND1 1.53951237846104 2.06769936282034e-17 0.789100261201456 1.48424202389562e-06 miRanda -0.111966511365121 0.000240262100008297 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 1.16509303143593 1.96641162209073e-13 0.789100261201456 1.48424202389562e-06 PITA -0.210173449112337 1.63510921192815e-09 NA NA NA hsa-miR-150-5p CCND1 -0.832049526091211 3.45299201139224e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.187252742453937 1.34917625164856e-11 NA NA NA hsa-miR-155-5p CCND1 1.09766314984151 4.55650930885814e-15 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.298681895389198 2.32439253453393e-14 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15b-5p CCND1 0.788659356634696 1.13678211092534e-11 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125463191460891 0.00921827566968511 NA NA NA hsa-miR-17-5p CCND1 0.599531757298529 1.07318660415906e-05 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.23795787679729 6.72139201694027e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.426987301460247 1.04129380549315e-05 0.789100261201456 1.48424202389562e-06 mirMAP -0.494988902443749 5.18517439622754e-18 NA NA NA hsa-miR-19a-3p CCND1 0.817507952171848 3.76285090469625e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.216023850578105 8.24189814452405e-09 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.647704962003062 3.07687667945597e-07 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase -0.206802040114629 3.03348057195458e-06 NA NA NA hsa-miR-19b-3p CCND1 0.139124391010031 0.255658553872934 0.789100261201456 1.48424202389562e-06 miRNATAP -0.249444343540709 5.93160032007176e-08 NA NA NA hsa-miR-20a-5p CCND1 0.44979911120222 0.000602386964327228 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218045690926451 3.58399990050218e-07 NA NA NA hsa-miR-214-5p CCND1 0.0510982283488062 0.676107227554816 0.789100261201456 1.48424202389562e-06 MirTarget -0.114200722915032 0.0138067660725528 NA NA NA hsa-miR-23b-3p CCND1 -0.363202401123049 0.000265305319764878 0.789100261201456 1.48424202389562e-06 miRNATAP -0.2085521275068 0.000237936656088415 NA NA NA hsa-miR-29a-3p CCND1 -0.699539666833076 1.13935003139957e-13 0.789100261201456 1.48424202389562e-06 mirMAP -0.358623457755512 1.12263469726765e-09 NA NA NA hsa-miR-340-5p CCND1 1.0857159627596 4.94471062546756e-24 0.789100261201456 1.48424202389562e-06 mirMAP -0.157803294541288 0.00210629660665075 NA NA NA hsa-miR-374a-5p CCND1 -0.239709888246804 0.00309819667153627 0.789100261201456 1.48424202389562e-06 MirTarget -0.556352001430099 7.67413515717595e-16 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 -0.466781429946153 1.17238311619116e-08 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget -0.531193112029599 5.3445494840887e-15 NA NA NA hsa-miR-424-5p CCND1 0.420789584199235 0.00480101660479489 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165346668007668 1.17175782770906e-05 NA NA NA hsa-miR-495-3p CCND1 -1.67685437612894 1.70634429769052e-34 0.789100261201456 1.48424202389562e-06 MirTarget -0.2655760978611 1.39010362325337e-11 NA NA NA hsa-miR-511-5p CCND1 -2.27545475897362 3.84085514050558e-36 0.789100261201456 1.48424202389562e-06 MirTarget -0.21938803198833 1.27831310404617e-13 NA NA NA hsa-miR-589-3p CCND1 0.0263457630961427 0.866577983997705 0.789100261201456 1.48424202389562e-06 MirTarget -0.116809863299678 0.00155105242627909 NA NA NA hsa-miR-590-3p CCND1 1.27438512890514 1.03164723481469e-23 0.789100261201456 1.48424202389562e-06 mirMAP -0.221641713536578 8.94498108920728e-07 NA NA NA hsa-miR-9-5p CCND1 0.734772328078424 0.00261982843636383 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.162121975003827 1.12937727530253e-12 NA NA NA hsa-miR-92a-3p CCND1 -0.342420481092807 0.000732275969501111 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate -0.355039027931141 1.3665845638516e-10 NA NA NA hsa-miR-93-5p CCND1 1.01788600209314 1.24312921618126e-21 0.789100261201456 1.48424202389562e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.160469090487963 0.00197437840989499 NA NA NA hsa-miR-942-5p CCND1 0.0274758353801279 0.842368857038259 0.789100261201456 1.48424202389562e-06 MirTarget -0.261175156275166 1.39422778172566e-10 NA NA NA hsa-let-7a-3p CCND2 0.466622567891891 3.70886257943079e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.215275364862757 3.63993039775257e-07 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7e-5p CCND2 0.261471269338985 0.00191077095550257 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.168033346737038 0.000309648297817392 NA NA NA hsa-miR-106a-5p CCND2 0.574594373206545 0.000145868284001732 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.117204496646304 5.04333413242193e-06 NA NA NA hsa-miR-106b-5p CCND2 1.22477789913175 2.31787213143326e-32 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.324304654054346 9.75129599972944e-20 NA NA NA hsa-miR-130b-5p CCND2 1.0573161199584 2.55177349228739e-12 -1.32381712777542 1.10807863083966e-33 mirMAP -0.113060251982174 8.9777676148938e-06 NA NA NA hsa-miR-141-3p CCND2 2.99777540204168 1.26370498493024e-78 -1.32381712777542 1.10807863083966e-33 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 NA NA NA hsa-miR-151a-3p CCND2 0.3530403796941 3.45015092968892e-05 -1.32381712777542 1.10807863083966e-33 mirMAP -0.17767569994557 0.000108302525662849 NA NA NA hsa-miR-15a-5p CCND2 0.812445324157528 4.50263417099822e-20 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382989347535057 1.85935181542133e-19 NA NA NA hsa-miR-15b-5p CCND2 0.788659356634696 1.13678211092534e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.200863767053961 1.18885859507843e-09 NA NA NA hsa-miR-16-5p CCND2 0.46835991343556 1.91125356547776e-06 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRNATAP -0.126011969570663 0.00149555991801246 NA NA NA hsa-miR-17-5p CCND2 0.599531757298529 1.07318660415906e-05 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.218141508896336 9.56625930755479e-15 NA NA NA hsa-miR-182-5p CCND2 2.36408084103818 2.60011457600281e-72 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.333755066801542 7.98233999507297e-38 NA NA NA hsa-miR-183-5p CCND2 2.95681814393872 1.09965777344285e-92 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.301857921065621 1.16754966176673e-39 NA NA NA hsa-miR-185-5p CCND2 0.482334746589337 3.68475879959415e-09 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.252091965164496 1.07493887045353e-07 NA NA NA hsa-miR-191-5p CCND2 0.831652724468215 1.98847993606895e-12 -1.32381712777542 1.10807863083966e-33 MirTarget -0.190841372088135 4.05600831845751e-09 NA NA NA hsa-miR-19a-3p CCND2 0.817507952171848 3.76285090469625e-08 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.185131062383478 6.94387115240903e-13 NA NA NA hsa-miR-19b-3p CCND2 0.139124391010031 0.255658553872934 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;MirTarget;miRNATAP -0.166767747836903 1.62862778749919e-07 NA NA NA hsa-miR-200a-3p CCND2 2.55218480823434 2.96135446816238e-51 -1.32381712777542 1.10807863083966e-33 MirTarget -0.261226562912324 4.31939405604759e-36 NA NA NA hsa-miR-20a-5p CCND2 0.44979911120222 0.000602386964327228 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;miRTarBase;miRNATAP -0.235095611327971 1.01223581717651e-15 NA NA NA hsa-miR-20b-5p CCND2 0.78236583455125 8.7938334801223e-05 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.104708964184932 6.77204420924901e-08 NA NA NA hsa-miR-21-3p CCND2 2.17476065946878 5.15299442583591e-75 -1.32381712777542 1.10807863083966e-33 mirMAP -0.127404398971718 2.08059143790106e-05 NA NA NA hsa-miR-29b-3p CCND2 0.438847962603729 6.46722433236121e-05 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.166630108966211 2.5453033344596e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 1.32170168375632 2.12280368957514e-15 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.182363632693643 1.4299291622836e-15 NA NA NA hsa-miR-3065-3p CCND2 1.62787885002468 6.81477830005026e-19 -1.32381712777542 1.10807863083966e-33 MirTarget;miRNATAP -0.215305118861858 1.68654607913855e-26 NA NA NA hsa-miR-30d-3p CCND2 0.264544633563642 0.00755023189129747 -1.32381712777542 1.10807863083966e-33 mirMAP -0.277305057640272 1.40644960106378e-12 NA NA NA hsa-miR-320b CCND2 0.412787504747938 0.00113457276903985 -1.32381712777542 1.10807863083966e-33 mirMAP;miRNATAP -0.105338094438455 0.000662995774848357 NA NA NA hsa-miR-324-3p CCND2 0.404877731996915 0.000340036423920834 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate -0.187482582074807 4.91214943402943e-08 NA NA NA hsa-miR-331-5p CCND2 0.682437632502949 4.10871642662371e-11 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.224823939820064 1.69348201302645e-09 NA NA NA hsa-miR-342-3p CCND2 1.21944481975657 6.81914373001202e-19 -1.32381712777542 1.10807863083966e-33 miRNAWalker2_validate;mirMAP -0.103848624831325 0.000189231379572542 NA NA NA hsa-miR-429 CCND2 2.84108892259147 3.88520896426515e-64 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.232180070081619 1.04111918722712e-28 NA NA NA hsa-miR-590-3p CCND2 1.27438512890514 1.03164723481469e-23 -1.32381712777542 1.10807863083966e-33 miRanda;mirMAP -0.13833737728579 9.4871454586344e-06 NA NA NA hsa-miR-590-5p CCND2 0.746515607868274 8.51300479640125e-09 -1.32381712777542 1.10807863083966e-33 mirMAP -0.151134124586935 3.93710909950627e-07 NA NA NA hsa-miR-660-5p CCND2 0.406910761707485 0.000156175371762464 -1.32381712777542 1.10807863083966e-33 mirMAP -0.106401121539045 0.00339848496849202 NA NA NA hsa-miR-7-1-3p CCND2 0.686579567507582 1.20731554448806e-07 -1.32381712777542 1.10807863083966e-33 mirMAP -0.138929082076826 3.22847149980611e-06 NA NA NA hsa-miR-93-5p CCND2 1.01788600209314 1.24312921618126e-21 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.400435186075896 5.37578279205249e-31 NA NA NA hsa-miR-96-5p CCND2 3.24596558166606 1.92296159041707e-98 -1.32381712777542 1.10807863083966e-33 TargetScan;miRNATAP -0.311897703713413 7.58506265459077e-49 NA NA NA hsa-miR-139-5p CCNF -3.25846663863766 2.62018989415003e-112 1.72141226490392 6.98913270118496e-68 miRanda -0.346517762328317 2.52596338883813e-64 NA NA NA hsa-miR-335-5p CCNF -2.61355235628987 2.6462884165886e-51 1.72141226490392 6.98913270118496e-68 MirTarget -0.200203030353317 7.18619027821685e-25 NA NA NA hsa-miR-21-5p CCNG1 2.32007501846389 3.08394781855554e-137 -0.866458495831471 1.01867596168613e-31 miRNAWalker2_validate -0.351124695573807 1.0959074492675e-55 NA NA NA hsa-miR-21-5p CCNG2 2.32007501846389 3.08394781855554e-137 -0.149650768150032 0.140842306998986 mirMAP -0.100576766109129 0.00147226728207765 NA NA NA hsa-miR-224-5p CCNG2 -2.22249420723892 1.07787949391113e-18 -0.149650768150032 0.140842306998986 mirMAP -0.124461718628112 3.77609224120173e-21 NA NA NA hsa-miR-200b-3p CCNJL 2.11744072703209 1.66710572104191e-43 -0.24201926034273 0.130052014695587 TargetScan -0.109705735774401 0.00120234945919895 NA NA NA hsa-miR-452-5p CCNO -2.48486455572568 1.24430987974325e-33 1.65363718784346 2.84295540967726e-08 MirTarget -0.268606219050328 1.76413182280284e-08 NA NA NA hsa-miR-200b-3p CCNYL1 2.11744072703209 1.66710572104191e-43 -0.335630850366162 2.14732890660635e-05 MirTarget;TargetScan -0.141068368642723 1.17774083265312e-17 NA NA NA hsa-miR-200c-3p CCNYL1 2.07038651806183 6.84613386286599e-51 -0.335630850366162 2.14732890660635e-05 MirTarget -0.123498507641419 1.41626967474554e-11 NA NA NA hsa-miR-141-3p CCPG1 2.99777540204168 1.26370498493024e-78 -0.529964991968035 4.71049768066572e-12 MirTarget;miRNATAP -0.120928259885471 3.34917437118351e-16 NA NA NA hsa-miR-200a-3p CCPG1 2.55218480823434 2.96135446816238e-51 -0.529964991968035 4.71049768066572e-12 MirTarget;miRNATAP -0.105196263517266 5.83806340900371e-13 NA NA NA hsa-miR-429 CCR2 2.84108892259147 3.88520896426515e-64 -0.337651625317303 0.0671809950743833 miRanda -0.118483207671968 0.00068888520335176 NA NA NA hsa-miR-139-5p CCT2 -3.25846663863766 2.62018989415003e-112 0.591905207253374 5.50326105697256e-18 miRanda -0.157107330884076 1.03071986829968e-29 NA NA NA hsa-miR-139-5p CCT5 -3.25846663863766 2.62018989415003e-112 0.8024096671385 6.78786862290181e-26 miRanda -0.196686299476611 4.97503463595942e-37 NA NA NA hsa-miR-139-5p CCT8 -3.25846663863766 2.62018989415003e-112 0.528280016875915 6.34596821623753e-18 miRanda -0.143590958259782 4.11477416747208e-31 NA NA NA hsa-miR-429 CD109 2.84108892259147 3.88520896426515e-64 -0.51774558606373 0.000831157534806843 miRanda -0.137261290871867 2.78399173790496e-06 NA NA NA hsa-miR-429 CD163 2.84108892259147 3.88520896426515e-64 -0.136961627077389 0.373708071191249 miRNATAP -0.124803332166306 1.74160826251592e-05 NA NA NA hsa-miR-335-5p CD177 -2.61355235628987 2.6462884165886e-51 2.18790354891148 2.17098281724119e-11 miRNAWalker2_validate -0.329309597546548 7.08491728518157e-08 NA NA NA hsa-miR-96-5p CD1D 3.24596558166606 1.92296159041707e-98 -0.0879748237517486 0.46095813882373 MirTarget -0.111123715908086 2.18675658316986e-06 NA NA NA hsa-miR-182-5p CD209 2.36408084103818 2.60011457600281e-72 -2.68996729671659 1.81210656486865e-45 mirMAP -0.69884525006299 7.7694684206421e-55 NA NA NA hsa-miR-182-5p CD226 2.36408084103818 2.60011457600281e-72 -0.186142386643432 0.236840278429222 MirTarget -0.150406594823481 5.74643308149989e-05 NA NA NA hsa-miR-139-5p CD24 -3.25846663863766 2.62018989415003e-112 1.34378402559882 1.65845881400111e-10 miRanda -0.365828370711475 1.65988095949599e-17 NA NA NA hsa-miR-182-5p CD274 2.36408084103818 2.60011457600281e-72 -0.376984029369696 0.0181142353017598 mirMAP -0.177729843716077 2.70981210575281e-06 NA NA NA hsa-miR-200a-3p CD274 2.55218480823434 2.96135446816238e-51 -0.376984029369696 0.0181142353017598 MirTarget -0.104573951616621 0.00058439454975885 NA NA NA hsa-miR-429 CD274 2.84108892259147 3.88520896426515e-64 -0.376984029369696 0.0181142353017598 miRanda -0.101307975642413 0.00079753366659523 NA NA NA hsa-miR-335-5p CD276 -2.61355235628987 2.6462884165886e-51 0.957090284528589 1.03993719710628e-44 miRNAWalker2_validate -0.125000421668986 1.05268510825667e-21 NA NA NA hsa-miR-429 CD34 2.84108892259147 3.88520896426515e-64 -2.06826167293265 9.93509189520513e-90 miRanda -0.348245735981653 2.21517049326077e-67 NA NA NA hsa-miR-96-5p CD36 3.24596558166606 1.92296159041707e-98 -4.94005353360482 1.40138697698687e-80 MirTarget -0.817524895192284 4.12167261993575e-53 NA NA NA hsa-miR-375 CD3G 2.09893673049766 1.68351780396203e-16 -0.255569353658802 0.270972373770412 miRanda -0.128112752370268 2.70123195444446e-05 NA NA NA hsa-miR-429 CD40LG 2.84108892259147 3.88520896426515e-64 -0.756943637914929 0.000503635115548591 miRanda -0.165689813324824 5.85846708285546e-05 NA NA NA hsa-miR-182-5p CD47 2.36408084103818 2.60011457600281e-72 -0.45420627000464 3.43710388441973e-08 MirTarget;miRNATAP -0.130514860898032 2.40190483124551e-11 NA NA NA hsa-miR-141-3p CD59 2.99777540204168 1.26370498493024e-78 -0.855467054419464 8.25618549169397e-22 mirMAP -0.10076056346922 1.11975519170288e-08 NA NA NA hsa-miR-182-5p CD59 2.36408084103818 2.60011457600281e-72 -0.855467054419464 8.25618549169397e-22 MirTarget -0.170054062793489 2.1252119909682e-15 NA NA NA hsa-miR-429 CD69 2.84108892259147 3.88520896426515e-64 -0.799422304431548 4.89915087426538e-06 miRNATAP -0.177858056383415 7.81975721107312e-08 NA NA NA hsa-miR-335-5p CD9 -2.61355235628987 2.6462884165886e-51 0.950703684742904 7.48613356045042e-31 miRNAWalker2_validate -0.153454581434635 3.06297600968284e-23 NA NA NA hsa-miR-429 CD96 2.84108892259147 3.88520896426515e-64 -0.493044332707044 0.0121552379268625 miRanda -0.147460428006152 7.364963363272e-05 NA NA NA hsa-miR-21-3p CDADC1 2.17476065946878 5.15299442583591e-75 -0.875753592457627 2.32227543558411e-56 MirTarget -0.198769862698004 7.51222614872729e-41 NA NA NA hsa-miR-429 CDADC1 2.84108892259147 3.88520896426515e-64 -0.875753592457627 2.32227543558411e-56 miRNATAP -0.109688857006494 1.06284612444128e-23 NA NA NA hsa-miR-141-3p CDC14A 2.99777540204168 1.26370498493024e-78 -1.23414445517375 6.16820708163778e-16 TargetScan;miRNATAP -0.136888602907261 5.43142578436724e-06 NA NA NA hsa-miR-200a-3p CDC14A 2.55218480823434 2.96135446816238e-51 -1.23414445517375 6.16820708163778e-16 miRNATAP -0.100138641411013 0.000721104667858655 NA NA NA hsa-miR-429 CDC14A 2.84108892259147 3.88520896426515e-64 -1.23414445517375 6.16820708163778e-16 miRanda -0.151181616097811 2.42780972015926e-07 NA NA NA hsa-miR-141-3p CDC14B 2.99777540204168 1.26370498493024e-78 -2.02470757063903 5.50090046332077e-71 mirMAP -0.345195446899158 1.85452830789045e-52 NA NA NA hsa-miR-183-5p CDC14B 2.95681814393872 1.09965777344285e-92 -2.02470757063903 5.50090046332077e-71 MirTarget -0.366803609743414 3.52967334708467e-50 NA NA NA hsa-miR-200a-3p CDC14B 2.55218480823434 2.96135446816238e-51 -2.02470757063903 5.50090046332077e-71 mirMAP -0.293218947907091 2.14473413178426e-38 NA NA NA hsa-miR-21-3p CDC14B 2.17476065946878 5.15299442583591e-75 -2.02470757063903 5.50090046332077e-71 mirMAP -0.35217194522348 8.71028295359471e-29 NA NA NA hsa-miR-429 CDC14B 2.84108892259147 3.88520896426515e-64 -2.02470757063903 5.50090046332077e-71 PITA;miRanda;miRNATAP -0.31370536352721 5.1329050278184e-45 NA NA NA hsa-miR-337-3p CDC25A -2.14274617598363 2.70942896809734e-43 2.05215023166215 3.612925024162e-38 mirMAP -0.348639875970048 7.23733595552888e-25 NA NA NA hsa-miR-141-5p CDC42BPA 2.38411349683216 4.56310582620282e-58 -0.66924322412178 9.81806271682457e-10 miRNATAP -0.110333272127169 3.0728162282539e-06 NA NA NA hsa-miR-182-5p CDC42BPA 2.36408084103818 2.60011457600281e-72 -0.66924322412178 9.81806271682457e-10 MirTarget;miRNATAP -0.167298681706304 1.4252871326823e-10 NA NA NA hsa-miR-200a-3p CDC42BPA 2.55218480823434 2.96135446816238e-51 -0.66924322412178 9.81806271682457e-10 mirMAP -0.150300294689266 5.12079916560305e-13 NA NA NA hsa-miR-429 CDC42BPA 2.84108892259147 3.88520896426515e-64 -0.66924322412178 9.81806271682457e-10 miRNATAP -0.149172578806871 5.31851287341571e-13 NA NA NA hsa-miR-96-5p CDC42BPA 3.24596558166606 1.92296159041707e-98 -0.66924322412178 9.81806271682457e-10 TargetScan;miRNATAP -0.147156524048822 9.82385556652648e-12 NA NA NA hsa-miR-141-3p CDC42EP3 2.99777540204168 1.26370498493024e-78 -1.05952015011567 1.54317380849048e-18 MirTarget;TargetScan -0.171981504132907 3.41196277513308e-13 NA NA NA hsa-miR-182-5p CDC42EP3 2.36408084103818 2.60011457600281e-72 -1.05952015011567 1.54317380849048e-18 mirMAP -0.217771532734969 5.2669361214532e-14 NA NA NA hsa-miR-200a-3p CDC42EP3 2.55218480823434 2.96135446816238e-51 -1.05952015011567 1.54317380849048e-18 MirTarget -0.131332641557507 1.81382117073955e-08 NA NA NA hsa-miR-200b-3p CDC42EP3 2.11744072703209 1.66710572104191e-43 -1.05952015011567 1.54317380849048e-18 TargetScan -0.144303536680923 2.70557595091107e-08 NA NA NA hsa-miR-429 CDC42EP3 2.84108892259147 3.88520896426515e-64 -1.05952015011567 1.54317380849048e-18 miRanda;miRNATAP -0.141249742548627 1.02475282569897e-09 NA NA NA hsa-miR-335-5p CDC7 -2.61355235628987 2.6462884165886e-51 1.63325833885766 1.18170870060963e-37 MirTarget -0.176434008401993 5.58066636177811e-13 NA NA NA hsa-miR-337-3p CDCA4 -2.14274617598363 2.70942896809734e-43 1.24196401151599 1.33835766521531e-46 MirTarget -0.192567154850615 5.38092513859583e-25 NA NA NA hsa-miR-139-5p CDCA7 -3.25846663863766 2.62018989415003e-112 0.454883969831319 0.0453855943845826 miRanda -0.235846366608642 4.11297574253193e-07 NA NA NA hsa-miR-139-5p CDCA8 -3.25846663863766 2.62018989415003e-112 2.86517600068357 4.0720557078808e-80 miRanda -0.564478940785059 6.94495719893017e-72 NA NA NA hsa-miR-335-5p CDCP1 -2.61355235628987 2.6462884165886e-51 1.16869868607199 5.37018733435812e-16 miRNAWalker2_validate -0.206042098237044 1.80495231917917e-14 NA NA NA hsa-miR-139-5p CDH1 -3.25846663863766 2.62018989415003e-112 0.993129597727878 4.15803450566148e-06 PITA;miRanda -0.256252618046659 7.41938846648008e-09 NA NA NA hsa-miR-139-5p CDH11 -3.25846663863766 2.62018989415003e-112 1.20920163585215 4.61017150120051e-17 miRanda -0.199282352616151 2.70736068996111e-11 NA NA NA hsa-miR-144-5p CDH11 -2.75914786146772 1.55794225315972e-50 1.20920163585215 4.61017150120051e-17 mirMAP -0.194647789101792 1.13740168566596e-14 NA NA NA hsa-miR-335-5p CDH11 -2.61355235628987 2.6462884165886e-51 1.20920163585215 4.61017150120051e-17 miRNAWalker2_validate -0.14988313233567 3.20971284994355e-08 NA NA NA hsa-miR-141-5p CDH19 2.38411349683216 4.56310582620282e-58 -3.45073434373508 6.54858840259774e-24 MirTarget -0.373879480646964 6.86685743920481e-07 NA NA NA hsa-miR-139-5p CDH2 -3.25846663863766 2.62018989415003e-112 1.79603953433003 3.53117483537472e-18 miRanda -0.439807325574357 1.92749263453179e-25 NA NA NA hsa-miR-452-5p CDH2 -2.48486455572568 1.24430987974325e-33 1.79603953433003 3.53117483537472e-18 miRNATAP -0.138218625809158 3.98822584108841e-05 NA NA NA hsa-miR-335-5p CDH3 -2.61355235628987 2.6462884165886e-51 -0.117784583322369 0.620312186055701 miRNAWalker2_validate -0.109175426564062 0.0134392929656588 NA NA NA hsa-miR-200a-5p CDH6 2.58844508672328 1.79650654234569e-56 -0.970669875320658 5.55111886434944e-15 mirMAP -0.196448071819219 5.56177809763226e-16 NA NA NA hsa-miR-200b-3p CDH6 2.11744072703209 1.66710572104191e-43 -0.970669875320658 5.55111886434944e-15 TargetScan -0.264470815531992 3.37380877825487e-24 NA NA NA hsa-miR-429 CDH6 2.84108892259147 3.88520896426515e-64 -0.970669875320658 5.55111886434944e-15 miRanda;miRNATAP -0.248000893049189 1.11094096699313e-26 NA NA NA hsa-miR-429 CDH8 2.84108892259147 3.88520896426515e-64 -1.56425428522844 1.43381833398179e-14 miRNATAP -0.244066254532831 3.15424797400247e-10 NA NA NA hsa-miR-139-5p CDK1 -3.25846663863766 2.62018989415003e-112 3.03160118593687 3.86639585044826e-86 miRanda -0.58467670477114 2.68119076496264e-73 NA NA NA hsa-miR-378a-5p CDK1 -2.43173551693523 1.44932837789175e-68 3.03160118593687 3.86639585044826e-86 MirTarget -0.209812293630406 5.76517787935358e-08 NA NA NA hsa-miR-486-5p CDK1 -3.87258704301474 1.22658629378451e-80 3.03160118593687 3.86639585044826e-86 miRanda -0.298405883829418 1.48918463498065e-32 NA NA NA hsa-miR-429 CDK14 2.84108892259147 3.88520896426515e-64 -0.433352050915716 5.35531560817009e-05 miRanda;miRNATAP -0.136185745676236 1.44112015478948e-11 NA NA NA hsa-miR-10b-5p CDK2 -2.10996264627796 7.36811595736367e-72 0.628977809366634 3.17063810755044e-21 miRNAWalker2_validate -0.172779155677722 1.52256449776603e-22 NA NA NA hsa-miR-139-5p CDK2AP1 -3.25846663863766 2.62018989415003e-112 0.369366443037257 2.65646177203751e-05 miRanda -0.127171491661432 1.33840339085344e-12 NA NA NA hsa-miR-145-5p CDK4 -2.62703571936687 7.64402900188551e-88 0.597969315491349 4.23701383421285e-22 miRNAWalker2_validate;miRTarBase -0.134364969525933 9.65405723067241e-21 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-141-3p CDK6 2.99777540204168 1.26370498493024e-78 -1.03099881099472 9.88361268912926e-12 TargetScan;miRNATAP -0.155074529575108 1.68227129058067e-07 NA NA NA hsa-miR-182-5p CDK6 2.36408084103818 2.60011457600281e-72 -1.03099881099472 9.88361268912926e-12 mirMAP -0.302395516858316 3.47976531991082e-17 NA NA NA hsa-miR-200a-3p CDK6 2.55218480823434 2.96135446816238e-51 -1.03099881099472 9.88361268912926e-12 miRNATAP -0.153245463849065 1.36473748839668e-07 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 2.11744072703209 1.66710572104191e-43 -1.03099881099472 9.88361268912926e-12 mirMAP -0.174815127052701 6.39294256795547e-08 NA NA NA hsa-miR-200c-3p CDK6 2.07038651806183 6.84613386286599e-51 -1.03099881099472 9.88361268912926e-12 mirMAP -0.180928310145507 3.68922155138771e-07 NA NA NA hsa-miR-21-5p CDK6 2.32007501846389 3.08394781855554e-137 -1.03099881099472 9.88361268912926e-12 miRNAWalker2_validate;mirMAP -0.197449989063307 3.4492907261557e-05 NA NA NA hsa-miR-429 CDK6 2.84108892259147 3.88520896426515e-64 -1.03099881099472 9.88361268912926e-12 mirMAP;miRNATAP -0.133862145668 3.72317905758963e-06 NA NA NA hsa-miR-139-5p CDK7 -3.25846663863766 2.62018989415003e-112 0.624526047543756 8.01865871956203e-25 miRanda -0.129552341625226 3.00181094423454e-25 NA NA NA hsa-miR-182-5p CDKN1A 2.36408084103818 2.60011457600281e-72 -0.254319078213554 0.025069242968496 miRNAWalker2_validate -0.114208671947908 2.29748891177513e-05 NA NA NA hsa-miR-96-5p CDKN1A 3.24596558166606 1.92296159041707e-98 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase -0.102209126041297 4.86561723152027e-06 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-429 CDKN1C 2.84108892259147 3.88520896426515e-64 -2.10696277121193 3.07611963088364e-54 miRNATAP -0.278468633884504 2.29984085584048e-25 NA NA NA hsa-miR-10b-5p CDKN2A -2.10996264627796 7.36811595736367e-72 2.12039399576679 1.36950972049671e-25 miRNAWalker2_validate;miRTarBase -0.715222702174389 1.70829699904957e-41 NA NA NA hsa-miR-429 CDKN2B 2.84108892259147 3.88520896426515e-64 -0.535762100005625 6.04515808229722e-05 miRanda -0.161930481171186 1.19377952611012e-10 NA NA NA hsa-miR-182-5p CDKN2C 2.36408084103818 2.60011457600281e-72 -1.07930959319688 4.54026994590945e-24 MirTarget -0.276641968146447 8.40974172250093e-28 NA NA NA hsa-miR-141-5p CDO1 2.38411349683216 4.56310582620282e-58 -3.96053657165666 6.36450825293181e-71 MirTarget -0.747240472078687 1.52601649687904e-52 NA NA NA hsa-miR-141-3p CDON 2.99777540204168 1.26370498493024e-78 -0.991164686357028 8.70119211480039e-13 TargetScan;miRNATAP -0.171828112637553 2.1850076679971e-10 NA NA NA hsa-miR-429 CDON 2.84108892259147 3.88520896426515e-64 -0.991164686357028 8.70119211480039e-13 miRanda;miRNATAP -0.126695362508865 1.76398596698427e-06 NA NA NA hsa-miR-452-5p CDON -2.48486455572568 1.24430987974325e-33 -0.991164686357028 8.70119211480039e-13 mirMAP -0.105461800597006 2.43148112170672e-06 NA NA NA hsa-miR-96-5p CDON 3.24596558166606 1.92296159041707e-98 -0.991164686357028 8.70119211480039e-13 miRNAWalker2_validate -0.109341366836116 8.06202408110221e-05 NA NA NA hsa-miR-141-5p CDR1 2.38411349683216 4.56310582620282e-58 -2.78303130363309 1.14022132656893e-32 MirTarget -0.460063772003728 2.52909206155818e-19 NA NA NA hsa-miR-145-5p CDR2L -2.62703571936687 7.64402900188551e-88 0.748814200369793 2.69929277775634e-18 MirTarget;miRNATAP -0.132831606499825 4.24854926303667e-11 NA NA NA hsa-miR-335-5p CDR2L -2.61355235628987 2.6462884165886e-51 0.748814200369793 2.69929277775634e-18 mirMAP -0.101141688579765 3.56945163469139e-10 NA NA NA hsa-miR-486-5p CDS1 -3.87258704301474 1.22658629378451e-80 1.12887729646206 2.18185707587295e-26 miRanda -0.165383036710311 1.6969754262043e-24 NA NA NA hsa-miR-335-5p CEACAM5 -2.61355235628987 2.6462884165886e-51 4.39441124053417 1.67886772733242e-22 miRNAWalker2_validate -0.479407056537049 1.95839103058109e-08 NA NA NA hsa-miR-182-5p CEBPA 2.36408084103818 2.60011457600281e-72 -1.63892839145041 1.92149075410583e-37 miRNATAP -0.270122687804452 7.3517474415241e-18 24653623 MiR 182 is up regulated and targeting Cebpa in hepatocellular carcinoma; In this study we find that miR-182 is upregulated in HCC model rat and represses CEBPA in both rat and human liver cancer hsa-miR-96-5p CEBPA 3.24596558166606 1.92296159041707e-98 -1.63892839145041 1.92149075410583e-37 miRNATAP -0.25472700588351 6.85389029825792e-23 NA NA NA hsa-miR-182-5p CECR1 2.36408084103818 2.60011457600281e-72 0.0525793816481563 0.678185967321492 mirMAP -0.142276844643684 2.16544188859461e-06 NA NA NA hsa-miR-200b-3p CECR2 2.11744072703209 1.66710572104191e-43 -0.71348448769862 0.0169057220752779 TargetScan -0.259441080900268 4.10916563552115e-05 NA NA NA hsa-miR-429 CECR2 2.84108892259147 3.88520896426515e-64 -0.71348448769862 0.0169057220752779 PITA;miRanda;miRNATAP -0.215036649203253 0.000142322246296138 NA NA NA hsa-miR-429 CECR7 2.84108892259147 3.88520896426515e-64 -1.89035599435696 3.55298751578156e-20 miRanda -0.119713256121675 0.000207909493914619 NA NA NA hsa-miR-335-5p CEL -2.61355235628987 2.6462884165886e-51 0.740396009396395 0.000668500028393413 miRNAWalker2_validate -0.122486009288575 0.00250697711715415 NA NA NA hsa-miR-141-3p CELF2 2.99777540204168 1.26370498493024e-78 -2.12375294826078 1.08191631254129e-58 mirMAP;miRNATAP -0.41339311906567 1.01135582231735e-58 NA NA NA hsa-miR-182-5p CELF2 2.36408084103818 2.60011457600281e-72 -2.12375294826078 1.08191631254129e-58 mirMAP;miRNATAP -0.481992232870267 1.79694380725177e-52 NA NA NA hsa-miR-183-5p CELF2 2.95681814393872 1.09965777344285e-92 -2.12375294826078 1.08191631254129e-58 miRNATAP -0.422755591255705 1.62957446448659e-51 NA NA NA hsa-miR-200a-3p CELF2 2.55218480823434 2.96135446816238e-51 -2.12375294826078 1.08191631254129e-58 mirMAP -0.350803565397106 1.22282287421629e-42 NA NA NA hsa-miR-200b-3p CELF2 2.11744072703209 1.66710572104191e-43 -2.12375294826078 1.08191631254129e-58 TargetScan;mirMAP -0.38083163724957 1.74055500746982e-40 NA NA NA hsa-miR-200c-3p CELF2 2.07038651806183 6.84613386286599e-51 -2.12375294826078 1.08191631254129e-58 mirMAP;miRNATAP -0.449875475207335 3.01578232376033e-47 NA NA NA hsa-miR-375 CELF2 2.09893673049766 1.68351780396203e-16 -2.12375294826078 1.08191631254129e-58 miRNAWalker2_validate -0.209006235349924 3.43998670014373e-31 NA NA NA hsa-miR-429 CELF2 2.84108892259147 3.88520896426515e-64 -2.12375294826078 1.08191631254129e-58 mirMAP;miRNATAP -0.34843146578855 1.20880580526075e-42 NA NA NA hsa-miR-96-5p CELF2 3.24596558166606 1.92296159041707e-98 -2.12375294826078 1.08191631254129e-58 TargetScan;miRNATAP -0.446018082809387 2.89181346314943e-67 NA NA NA hsa-miR-183-5p CELF6 2.95681814393872 1.09965777344285e-92 -0.80109020682177 1.24560352545111e-09 MirTarget -0.167416674566609 1.80033779095872e-09 NA NA NA hsa-miR-139-5p CELSR1 -3.25846663863766 2.62018989415003e-112 1.61634533287919 6.59604647943385e-22 miRanda -0.190972329034552 6.22900071908511e-08 NA NA NA hsa-miR-335-5p CELSR3 -2.61355235628987 2.6462884165886e-51 2.03979589782204 6.92992968851562e-29 miRNAWalker2_validate -0.196162717289258 2.01356307648801e-08 NA NA NA hsa-miR-486-5p CELSR3 -3.87258704301474 1.22658629378451e-80 2.03979589782204 6.92992968851562e-29 miRNATAP -0.161773565467608 1.52072099359118e-08 NA NA NA hsa-miR-139-5p CENPF -3.25846663863766 2.62018989415003e-112 3.11514514441071 2.48792184625561e-82 miRanda -0.609092574172232 1.72009397886452e-72 NA NA NA hsa-miR-10b-5p CENPO -2.10996264627796 7.36811595736367e-72 1.19588338610843 1.48644310539104e-34 mirMAP -0.382408509483701 5.55208784352153e-51 NA NA NA hsa-miR-335-5p CENPP -2.61355235628987 2.6462884165886e-51 1.38859803247114 1.24507134095326e-33 mirMAP -0.1574981651066 7.39431187644052e-13 NA NA NA hsa-miR-139-5p CENPW -3.25846663863766 2.62018989415003e-112 1.13047287035334 1.21789082581454e-14 miRanda -0.279068513749155 1.25927949394492e-20 NA NA NA hsa-miR-141-3p CEP120 2.99777540204168 1.26370498493024e-78 -0.637906841352931 9.59571458000669e-20 MirTarget;miRNATAP -0.107211534312174 5.51493473049517e-15 NA NA NA hsa-miR-429 CEP120 2.84108892259147 3.88520896426515e-64 -0.637906841352931 9.59571458000669e-20 miRanda;miRNATAP -0.114933108066199 6.07146151657627e-18 NA NA NA hsa-miR-21-5p CEP152 2.32007501846389 3.08394781855554e-137 -0.466748071928451 8.62329147321542e-07 miRNAWalker2_validate -0.123326725657416 3.18390296813198e-05 NA NA NA hsa-miR-200b-3p CEP68 2.11744072703209 1.66710572104191e-43 -1.31835189113776 7.12744930214818e-101 MirTarget -0.157171623230992 9.38037557270443e-28 NA NA NA hsa-miR-200c-3p CEP68 2.07038651806183 6.84613386286599e-51 -1.31835189113776 7.12744930214818e-101 MirTarget -0.185773136893312 3.69638298679941e-32 NA NA NA hsa-miR-21-5p CEP68 2.32007501846389 3.08394781855554e-137 -1.31835189113776 7.12744930214818e-101 miRNATAP -0.392295121745729 9.51485413821928e-90 NA NA NA hsa-miR-429 CEP68 2.84108892259147 3.88520896426515e-64 -1.31835189113776 7.12744930214818e-101 MirTarget;miRanda -0.179227635802544 2.64853813206664e-46 NA NA NA hsa-miR-335-5p CEP72 -2.61355235628987 2.6462884165886e-51 0.665685620938733 1.82148670370334e-14 mirMAP -0.106050454216207 6.26659406039502e-11 NA NA NA hsa-miR-21-5p CEP97 2.32007501846389 3.08394781855554e-137 0.0594520959000202 0.595486410195853 miRNAWalker2_validate;MirTarget -0.104490812571317 0.00271559146234075 NA NA NA hsa-miR-335-5p CERCAM -2.61355235628987 2.6462884165886e-51 1.0552492107226 2.97170105719356e-25 miRNAWalker2_validate -0.154894996986184 5.64613228833798e-16 NA NA NA hsa-miR-486-5p CERCAM -3.87258704301474 1.22658629378451e-80 1.0552492107226 2.97170105719356e-25 miRanda -0.10882319535178 4.51215245099695e-12 NA NA NA hsa-miR-335-5p CFB -2.61355235628987 2.6462884165886e-51 1.89314278564533 3.11554096511835e-15 miRNAWalker2_validate -0.233646423299202 2.26178843919246e-07 NA NA NA hsa-miR-429 CFH 2.84108892259147 3.88520896426515e-64 -1.36280680946721 1.93284644424144e-25 miRanda -0.339739804615836 6.98641001518312e-45 NA NA NA hsa-miR-141-3p CFL2 2.99777540204168 1.26370498493024e-78 -1.90866764374212 6.50763441219441e-93 TargetScan -0.326572218109566 4.92408445395296e-68 NA NA NA hsa-miR-200b-3p CFL2 2.11744072703209 1.66710572104191e-43 -1.90866764374212 6.50763441219441e-93 MirTarget;TargetScan -0.298081117582125 1.57474476734891e-45 NA NA NA hsa-miR-200c-3p CFL2 2.07038651806183 6.84613386286599e-51 -1.90866764374212 6.50763441219441e-93 MirTarget;miRNATAP -0.380708052394068 1.28877470594683e-63 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c breast cancer hsa-miR-375 CFL2 2.09893673049766 1.68351780396203e-16 -1.90866764374212 6.50763441219441e-93 miRNAWalker2_validate -0.133525831147668 3.88420426614421e-23 NA NA NA hsa-miR-429 CFL2 2.84108892259147 3.88520896426515e-64 -1.90866764374212 6.50763441219441e-93 MirTarget;PITA;miRanda;miRNATAP -0.260955344678496 1.27958186666412e-43 NA NA NA hsa-miR-335-5p CGA -2.61355235628987 2.6462884165886e-51 2.94216285501933 3.48975119604516e-10 miRNAWalker2_validate -0.206504063677759 0.0191240725884551 NA NA NA hsa-miR-139-5p CGN -3.25846663863766 2.62018989415003e-112 1.78073809221264 8.44224299274448e-26 miRanda -0.253910889171866 9.38290650730895e-13 NA NA NA hsa-miR-335-5p CHAC1 -2.61355235628987 2.6462884165886e-51 1.13858997109335 3.28010309027483e-11 miRNAWalker2_validate -0.195585092022699 9.80283459173677e-10 NA NA NA hsa-miR-139-5p CHAC2 -3.25846663863766 2.62018989415003e-112 0.544096936191264 4.42023817052818e-07 miRanda -0.16833503768005 1.91519227880389e-14 NA NA NA hsa-miR-145-5p CHAC2 -2.62703571936687 7.64402900188551e-88 0.544096936191264 4.42023817052818e-07 MirTarget -0.122101284982284 1.10969565965746e-06 NA NA NA hsa-miR-337-3p CHAF1A -2.14274617598363 2.70942896809734e-43 1.08120022982577 1.42386737215685e-34 PITA -0.242480384714605 5.21935991115408e-40 NA NA NA hsa-miR-139-5p CHCHD1 -3.25846663863766 2.62018989415003e-112 0.933453445179662 3.22630270560198e-35 miRanda -0.167596730719306 1.29258461479662e-26 NA NA NA hsa-miR-10b-5p CHD5 -2.10996264627796 7.36811595736367e-72 -0.229665210408944 0.287178999472367 mirMAP -0.226419810924134 7.89220851664661e-05 NA NA NA hsa-miR-221-3p CHD8 -0.317970198201501 0.00910855267413448 0.0239791945831058 0.650321619476731 MirTarget;miRNATAP -0.147913788096852 9.94945179288004e-25 NA NA NA hsa-miR-141-3p CHD9 2.99777540204168 1.26370498493024e-78 -1.20641724676964 1.8510450370295e-34 MirTarget;TargetScan;miRNATAP -0.182190145306071 1.03264917281218e-20 NA NA NA hsa-miR-182-5p CHD9 2.36408084103818 2.60011457600281e-72 -1.20641724676964 1.8510450370295e-34 mirMAP -0.158549992919965 6.14313830866828e-11 NA NA NA hsa-miR-200a-3p CHD9 2.55218480823434 2.96135446816238e-51 -1.20641724676964 1.8510450370295e-34 MirTarget;miRNATAP -0.145625348339878 4.83128038510931e-14 NA NA NA hsa-miR-200b-3p CHD9 2.11744072703209 1.66710572104191e-43 -1.20641724676964 1.8510450370295e-34 TargetScan;mirMAP -0.163983661372598 2.28493846391535e-14 NA NA NA hsa-miR-200c-3p CHD9 2.07038651806183 6.84613386286599e-51 -1.20641724676964 1.8510450370295e-34 mirMAP;miRNATAP -0.189232134031131 1.01551746966713e-15 NA NA NA hsa-miR-429 CHD9 2.84108892259147 3.88520896426515e-64 -1.20641724676964 1.8510450370295e-34 PITA;miRanda;mirMAP;miRNATAP -0.173203806994596 9.57605467605631e-20 NA NA NA hsa-miR-139-5p CHEK1 -3.25846663863766 2.62018989415003e-112 1.25798968980226 1.05480144252256e-29 miRanda -0.300486863727614 2.11897109250447e-40 NA NA NA hsa-miR-139-5p CHERP -3.25846663863766 2.62018989415003e-112 0.513900286138767 1.95993290902599e-21 miRanda -0.105088970661837 3.17749788366774e-21 NA NA NA hsa-miR-182-5p CHL1 2.36408084103818 2.60011457600281e-72 -4.19000522865994 8.63027491138316e-64 MirTarget;miRNATAP -0.685386106155704 2.56345859782032e-28 24971532 miR 182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma; Bioinformatics analysis revealed close homolog of LI CHL1 as a potential target of miR-182; Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines; miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3'-untranslated region 3'-UTR; Silencing of CHL1 counteracted the effects of miR-182 suppression while its overexpression mimicked these effects; Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1 supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC thyroid cancer hsa-miR-200a-5p CHL1 2.58844508672328 1.79650654234569e-56 -4.19000522865994 8.63027491138316e-64 MirTarget;miRNATAP -0.55338577454482 1.79380625150581e-27 20957176 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis and highlight novel distinguishing characteristics of individual miR-200 family members metastasis melanoma hsa-miR-21-3p CHL1 2.17476065946878 5.15299442583591e-75 -4.19000522865994 8.63027491138316e-64 MirTarget -0.653186694046858 4.10662928485231e-21 NA NA NA hsa-miR-335-5p CHMP1A -2.61355235628987 2.6462884165886e-51 0.530362609793901 4.42725325443373e-14 mirMAP -0.101256798965506 8.08213606950577e-15 NA NA NA hsa-miR-139-5p CHMP4B -3.25846663863766 2.62018989415003e-112 0.743844618951224 1.53270495061887e-35 miRanda -0.130057740574642 1.64228870036204e-25 NA NA NA hsa-miR-200c-3p CHN2 2.07038651806183 6.84613386286599e-51 -0.112685595485043 0.45906561565987 MirTarget -0.15719708908879 8.71100552677592e-06 NA NA NA hsa-miR-429 CHN2 2.84108892259147 3.88520896426515e-64 -0.112685595485043 0.45906561565987 MirTarget;PITA;miRanda;miRNATAP -0.10615043582389 0.000223231899219313 NA NA NA hsa-miR-375 CHODL 2.09893673049766 1.68351780396203e-16 -2.01433678971644 3.11757059994944e-14 miRanda -0.477636573777808 8.20219259497187e-46 NA NA NA hsa-miR-139-5p CHPF -3.25846663863766 2.62018989415003e-112 1.57981358229743 7.97156351354461e-58 miRNATAP -0.264190409373042 9.91509026409078e-37 NA NA NA hsa-miR-10b-5p CHPF2 -2.10996264627796 7.36811595736367e-72 0.922704490510655 3.74157729160942e-44 miRNAWalker2_validate -0.188268762677214 2.09659029132791e-25 NA NA NA hsa-miR-141-3p CHRDL1 2.99777540204168 1.26370498493024e-78 -5.39923527570506 3.1404637677735e-65 MirTarget;TargetScan -0.938805684928036 1.6382769374349e-50 NA NA NA hsa-miR-200a-3p CHRDL1 2.55218480823434 2.96135446816238e-51 -5.39923527570506 3.1404637677735e-65 MirTarget -0.745909670515544 3.13252730232654e-32 NA NA NA hsa-miR-200b-3p CHRDL1 2.11744072703209 1.66710572104191e-43 -5.39923527570506 3.1404637677735e-65 MirTarget;TargetScan -0.737728194993491 2.11393379082638e-25 NA NA NA hsa-miR-200c-3p CHRDL1 2.07038651806183 6.84613386286599e-51 -5.39923527570506 3.1404637677735e-65 MirTarget -0.918552583080221 1.08987902824998e-32 NA NA NA hsa-miR-429 CHRDL1 2.84108892259147 3.88520896426515e-64 -5.39923527570506 3.1404637677735e-65 MirTarget;miRanda;miRNATAP -0.74685625804435 8.95614370149719e-33 NA NA NA hsa-miR-375 CHRM3 2.09893673049766 1.68351780396203e-16 -1.40484467518279 2.85926221540521e-09 miRNATAP -0.258393358563914 6.6349206229292e-17 NA NA NA hsa-miR-378a-5p CHRNB2 -2.43173551693523 1.44932837789175e-68 -0.802935916123597 0.00135371743351536 mirMAP -0.135422426748285 0.0173254571218412 NA NA NA hsa-miR-10b-5p CHST11 -2.10996264627796 7.36811595736367e-72 1.18940887994169 1.7660331610339e-25 mirMAP -0.218957727331879 1.47612156791125e-12 NA NA NA hsa-miR-200b-3p CHST2 2.11744072703209 1.66710572104191e-43 -0.894882854431295 9.62306233410265e-12 TargetScan -0.123073817043257 1.20850921730603e-05 NA NA NA hsa-miR-200c-3p CHST2 2.07038651806183 6.84613386286599e-51 -0.894882854431295 9.62306233410265e-12 miRNATAP -0.176242768894039 1.05560685819567e-08 NA NA NA hsa-miR-429 CHST2 2.84108892259147 3.88520896426515e-64 -0.894882854431295 9.62306233410265e-12 miRanda;miRNATAP -0.106432253604749 2.27123796678108e-05 NA NA NA hsa-miR-141-5p CHST3 2.38411349683216 4.56310582620282e-58 -1.59739453618256 1.85471799803448e-30 mirMAP -0.294947738419103 1.93332650531219e-22 NA NA NA hsa-miR-429 CHST3 2.84108892259147 3.88520896426515e-64 -1.59739453618256 1.85471799803448e-30 miRNATAP -0.218368063396633 4.99336095268242e-16 NA NA NA hsa-miR-335-5p CHST6 -2.61355235628987 2.6462884165886e-51 1.65841308995491 3.80813455100364e-17 miRNAWalker2_validate -0.290498150548304 2.65276390043619e-15 NA NA NA hsa-miR-429 CHST7 2.84108892259147 3.88520896426515e-64 -1.02364224319124 4.8168689226113e-30 miRanda;miRNATAP -0.196757642620483 6.34782415327307e-31 NA NA NA hsa-miR-200b-3p CHST9 2.11744072703209 1.66710572104191e-43 -3.48668023282491 1.2009377943548e-28 TargetScan -0.153842615392145 0.0259139501805727 NA NA NA hsa-miR-429 CHST9 2.84108892259147 3.88520896426515e-64 -3.48668023282491 1.2009377943548e-28 miRNATAP -0.30173806538391 8.63642830370168e-07 NA NA NA hsa-miR-200b-3p CHSY3 2.11744072703209 1.66710572104191e-43 0.306225149612841 0.00899058774478209 TargetScan -0.199745631127982 3.1589862956474e-16 NA NA NA hsa-miR-429 CHSY3 2.84108892259147 3.88520896426515e-64 0.306225149612841 0.00899058774478209 miRanda -0.138357707807315 3.28163443841795e-10 NA NA NA hsa-miR-378a-5p CHTF18 -2.43173551693523 1.44932837789175e-68 2.00904749765085 6.9319368545837e-46 miRNAWalker2_validate -0.342052247000073 2.61370728789265e-25 NA NA NA hsa-miR-429 CHURC1 2.84108892259147 3.88520896426515e-64 -0.524397535736656 5.80040892470647e-17 miRanda;miRNATAP -0.101475595304888 1.0808189966943e-17 NA NA NA hsa-miR-139-5p CIAPIN1 -3.25846663863766 2.62018989415003e-112 0.35365086330169 7.90576915499109e-09 MirTarget;miRanda -0.104717541648853 4.51264172677045e-17 NA NA NA hsa-miR-183-5p CIITA 2.95681814393872 1.09965777344285e-92 3.17304700732102e-05 0.999824310007578 mirMAP -0.1301454345274 1.68342764562729e-05 NA NA NA hsa-miR-139-5p CISD1 -3.25846663863766 2.62018989415003e-112 0.359244746632374 5.50163057446118e-07 miRanda -0.115442054105779 2.68061922030962e-15 NA NA NA hsa-miR-139-5p CIT -3.25846663863766 2.62018989415003e-112 2.04718869890754 1.61616226629049e-61 miRanda -0.376378475410778 1.17629186471052e-47 NA NA NA hsa-miR-486-5p CIT -3.87258704301474 1.22658629378451e-80 2.04718869890754 1.61616226629049e-61 MirTarget;PITA;miRanda;miRNATAP -0.199911184585402 4.53718390957286e-24 NA NA NA hsa-miR-141-5p CITED2 2.38411349683216 4.56310582620282e-58 -0.834044357426571 4.4609160487977e-15 miRNATAP -0.146363170725033 1.9947635053809e-10 NA NA NA hsa-miR-200b-3p CITED2 2.11744072703209 1.66710572104191e-43 -0.834044357426571 4.4609160487977e-15 TargetScan -0.111145966106192 1.13080439681397e-06 NA NA NA hsa-miR-200c-3p CITED2 2.07038651806183 6.84613386286599e-51 -0.834044357426571 4.4609160487977e-15 miRNATAP -0.130545886780671 1.94917710455014e-07 NA NA NA hsa-miR-429 CITED2 2.84108892259147 3.88520896426515e-64 -0.834044357426571 4.4609160487977e-15 PITA;miRanda;miRNATAP -0.124087366936768 9.96796181977804e-10 NA NA NA hsa-miR-139-5p CKAP4 -3.25846663863766 2.62018989415003e-112 1.02452120868339 2.78775725106043e-41 miRanda -0.201599290902243 1.66655423108919e-37 NA NA NA hsa-miR-139-5p CKS2 -3.25846663863766 2.62018989415003e-112 2.56866714839802 4.02901263433163e-91 miRanda -0.504270621606752 8.47886718092088e-81 NA NA NA hsa-miR-375 CLCA4 2.09893673049766 1.68351780396203e-16 -4.65719360312502 5.72182509941717e-53 miRNATAP -0.288939458266416 9.40997228303352e-12 NA NA NA hsa-miR-335-5p CLCN2 -2.61355235628987 2.6462884165886e-51 1.45495613487863 1.05482475729363e-52 miRNAWalker2_validate -0.133210974631185 9.32447038896588e-13 NA NA NA hsa-miR-141-3p CLCN6 2.99777540204168 1.26370498493024e-78 -1.07256558516376 2.54953953731211e-64 MirTarget -0.187515408739221 1.10347614148443e-50 NA NA NA hsa-miR-141-5p CLCN6 2.38411349683216 4.56310582620282e-58 -1.07256558516376 2.54953953731211e-64 mirMAP -0.172498234285508 3.04236842673971e-34 NA NA NA hsa-miR-182-5p CLCN6 2.36408084103818 2.60011457600281e-72 -1.07256558516376 2.54953953731211e-64 mirMAP -0.160690220589501 5.11388975159918e-24 NA NA NA hsa-miR-183-5p CLCN6 2.95681814393872 1.09965777344285e-92 -1.07256558516376 2.54953953731211e-64 mirMAP -0.200844768750328 2.38493484693553e-49 NA NA NA hsa-miR-200a-3p CLCN6 2.55218480823434 2.96135446816238e-51 -1.07256558516376 2.54953953731211e-64 MirTarget -0.113063803690566 1.11238114512559e-18 NA NA NA hsa-miR-429 CLCN6 2.84108892259147 3.88520896426515e-64 -1.07256558516376 2.54953953731211e-64 miRanda -0.132854950591914 5.64296297598463e-26 NA NA NA hsa-miR-96-5p CLCN6 3.24596558166606 1.92296159041707e-98 -1.07256558516376 2.54953953731211e-64 mirMAP -0.169857585094236 1.92022830902364e-39 NA NA NA hsa-miR-375 CLDN1 2.09893673049766 1.68351780396203e-16 -0.276713557837169 0.180196698823412 miRNAWalker2_validate -0.156974953306406 6.26959435563226e-09 25001509 Claudin 1 is a novel target of miR 375 in non small cell lung cancer; Claudin-1 CLDN1 has 4 putative miR-375 target sites in its 3'-untranslated region and this gene was determined to be a target of miR-375; CLDN1 messenger RNA and protein expression were attenuated by overexpression of miR-375 and increased by knockdown of miR-375 in NSCLC cell lines; In clinical NSCLC samples there was a negative correlation between miR-375 and CLDN1 expression r=-0.35 P=0.005; CLDN1 is a novel target of miR-375 and high miR-375 expression shortens survival in NSCLC poor survival lung squamous cell cancer hsa-miR-335-5p CLDN14 -2.61355235628987 2.6462884165886e-51 2.10055619494406 8.50445023448768e-28 miRNAWalker2_validate -0.309093219593828 1.51497067963958e-17 NA NA NA hsa-miR-429 CLDN2 2.84108892259147 3.88520896426515e-64 -2.2919698020588 5.57258019022737e-23 miRNATAP -0.297056215371534 3.1566452745707e-11 NA NA NA hsa-miR-139-5p CLDN4 -3.25846663863766 2.62018989415003e-112 1.40171092841636 1.40336046500233e-20 miRanda -0.24496267076653 5.01857593043687e-15 NA NA NA hsa-miR-335-5p CLDN4 -2.61355235628987 2.6462884165886e-51 1.40171092841636 1.40336046500233e-20 miRNAWalker2_validate -0.195913886809147 4.89043999528207e-12 NA NA NA hsa-miR-335-5p CLDN7 -2.61355235628987 2.6462884165886e-51 1.85144869311166 5.65997572806905e-40 miRNAWalker2_validate -0.246190841936697 3.05145118369811e-20 NA NA NA hsa-miR-486-5p CLDN7 -3.87258704301474 1.22658629378451e-80 1.85144869311166 5.65997572806905e-40 miRanda -0.219121891405829 6.7411893962181e-24 NA NA NA hsa-miR-21-5p CLDN8 2.32007501846389 3.08394781855554e-137 -2.40586022995905 3.18872712875525e-15 MirTarget -0.377817106851424 9.19914627852771e-05 NA NA NA hsa-miR-145-5p CLDN9 -2.62703571936687 7.64402900188551e-88 1.64165748779949 3.68664643181565e-16 MirTarget -0.320357694047292 1.09177103573848e-11 NA NA NA hsa-miR-335-5p CLEC11A -2.61355235628987 2.6462884165886e-51 1.4457695068248 5.21017768649093e-23 miRNAWalker2_validate -0.247333825113528 1.53592203693085e-19 NA NA NA hsa-miR-375 CLEC2B 2.09893673049766 1.68351780396203e-16 -0.752784538838791 4.80096301835902e-13 miRanda -0.105410776848508 1.52461699785913e-14 NA NA NA hsa-miR-429 CLEC2B 2.84108892259147 3.88520896426515e-64 -0.752784538838791 4.80096301835902e-13 miRanda -0.19294525065635 3.86099148725352e-23 NA NA NA hsa-miR-139-5p CLEC5A -3.25846663863766 2.62018989415003e-112 2.96513545031031 6.0413530716724e-58 miRanda -0.602977578694984 3.46415796455673e-56 NA NA NA hsa-miR-486-5p CLGN -3.87258704301474 1.22658629378451e-80 1.90694496343987 1.87862072890871e-11 miRanda -0.261185026364696 1.65787642629561e-09 NA NA NA hsa-miR-21-5p CLIC2 2.32007501846389 3.08394781855554e-137 -1.44332821459599 5.81048457729843e-41 MirTarget -0.304444862008348 1.38670679779218e-18 NA NA NA hsa-miR-335-5p CLIC3 -2.61355235628987 2.6462884165886e-51 1.69084413377066 7.56800168321288e-15 miRNAWalker2_validate -0.351710038586407 2.51844936680107e-18 NA NA NA hsa-miR-141-3p CLIC4 2.99777540204168 1.26370498493024e-78 -0.604325972745405 4.39590515801355e-12 MirTarget -0.131054810035266 9.34162799392801e-15 NA NA NA hsa-miR-200a-3p CLIC4 2.55218480823434 2.96135446816238e-51 -0.604325972745405 4.39590515801355e-12 MirTarget -0.114588073259131 6.01582269497717e-12 NA NA NA hsa-miR-200b-3p CLIC4 2.11744072703209 1.66710572104191e-43 -0.604325972745405 4.39590515801355e-12 MirTarget;TargetScan -0.129255066502504 2.95832614236725e-12 NA NA NA hsa-miR-200c-3p CLIC4 2.07038651806183 6.84613386286599e-51 -0.604325972745405 4.39590515801355e-12 MirTarget;miRNATAP -0.154596823858339 2.69440260316856e-14 NA NA NA hsa-miR-182-5p CLIC5 2.36408084103818 2.60011457600281e-72 -2.45158209396745 6.04401125299923e-58 miRNATAP -0.432657732915873 2.35600149169964e-30 NA NA NA hsa-miR-429 CLIC5 2.84108892259147 3.88520896426515e-64 -2.45158209396745 6.04401125299923e-58 miRanda -0.389583958434854 2.39157179035248e-39 NA NA NA hsa-miR-96-5p CLIC5 3.24596558166606 1.92296159041707e-98 -2.45158209396745 6.04401125299923e-58 TargetScan;miRNATAP -0.427581680120126 8.34645044643189e-44 NA NA NA hsa-miR-200c-3p CLIP2 2.07038651806183 6.84613386286599e-51 -0.0838401200209011 0.328928067723523 MirTarget;miRNATAP -0.121175791833096 9.84176257133331e-10 NA NA NA hsa-miR-429 CLIP3 2.84108892259147 3.88520896426515e-64 -0.992759770033128 5.05293540806059e-24 miRNATAP -0.179913838761775 5.50352476378843e-22 NA NA NA hsa-miR-21-5p CLIP4 2.32007501846389 3.08394781855554e-137 -2.3151033395124 1.73675077418303e-45 miRNAWalker2_validate -0.479427264370382 1.10360006264809e-19 NA NA NA hsa-miR-429 CLIP4 2.84108892259147 3.88520896426515e-64 -2.3151033395124 1.73675077418303e-45 miRanda -0.306813961713714 9.08753922441754e-22 NA NA NA hsa-miR-141-3p CLN8 2.99777540204168 1.26370498493024e-78 -0.548479642156373 3.86536491552494e-14 mirMAP -0.113504362082432 6.81558332072343e-16 NA NA NA hsa-miR-200a-3p CLN8 2.55218480823434 2.96135446816238e-51 -0.548479642156373 3.86536491552494e-14 mirMAP -0.101402440654349 2.34966650749595e-13 NA NA NA hsa-miR-200b-3p CLOCK 2.11744072703209 1.66710572104191e-43 -0.444410941110669 0.00108938309187277 MirTarget;TargetScan -0.104862943483691 0.000281770903559823 NA NA NA hsa-miR-21-5p CLOCK 2.32007501846389 3.08394781855554e-137 -0.444410941110669 0.00108938309187277 miRNAWalker2_validate -0.236507234922591 2.09692691035731e-08 NA NA NA hsa-miR-10b-5p CLPTM1 -2.10996264627796 7.36811595736367e-72 0.506189789927412 2.92598418451613e-19 miRNAWalker2_validate -0.146807503137754 9.02921699821944e-23 NA NA NA hsa-miR-429 CLVS1 2.84108892259147 3.88520896426515e-64 -1.38953570751026 3.88136587878955e-13 miRanda;miRNATAP -0.206705759774795 1.530065677446e-08 NA NA NA hsa-miR-141-3p CLYBL 2.99777540204168 1.26370498493024e-78 -0.878691118021466 1.98105321641431e-17 mirMAP -0.125666097016546 6.30213828560257e-10 NA NA NA hsa-miR-141-5p CLYBL 2.38411349683216 4.56310582620282e-58 -0.878691118021466 1.98105321641431e-17 mirMAP -0.147019813366827 5.52927083029365e-11 NA NA NA hsa-miR-21-3p CLYBL 2.17476065946878 5.15299442583591e-75 -0.878691118021466 1.98105321641431e-17 mirMAP -0.207817108666559 3.12366052075826e-14 NA NA NA hsa-miR-429 CLYBL 2.84108892259147 3.88520896426515e-64 -0.878691118021466 1.98105321641431e-17 miRNATAP -0.109798385691807 3.17598059363638e-08 NA NA NA hsa-miR-96-5p CMTM7 3.24596558166606 1.92296159041707e-98 -1.18073050355747 1.13405428106606e-16 TargetScan -0.224980405671691 1.63334519356355e-15 NA NA NA hsa-miR-145-5p CNDP2 -2.62703571936687 7.64402900188551e-88 0.621184844531254 3.98272801079302e-22 MirTarget -0.106594291962046 1.68877714907214e-12 NA NA NA hsa-miR-335-5p CNFN -2.61355235628987 2.6462884165886e-51 1.0552141380032 1.36623130741429e-11 miRNAWalker2_validate -0.156089739198646 8.83444143732194e-08 NA NA NA hsa-miR-335-5p CNIH2 -2.61355235628987 2.6462884165886e-51 3.45537046189226 6.19315546111584e-77 miRNAWalker2_validate -0.386529252741812 1.5598602032784e-25 NA NA NA hsa-miR-10b-5p CNIH4 -2.10996264627796 7.36811595736367e-72 0.608573247052616 8.71751032452955e-15 MirTarget -0.173692484339407 8.22197365013596e-17 NA NA NA hsa-miR-139-5p CNIH4 -3.25846663863766 2.62018989415003e-112 0.608573247052616 8.71751032452955e-15 miRanda -0.15770639249165 5.66764634401951e-23 NA NA NA hsa-miR-139-5p CNKSR1 -3.25846663863766 2.62018989415003e-112 1.44823291536679 2.12293533329982e-27 miRanda -0.26068086461249 6.00981867437552e-21 NA NA NA hsa-miR-486-5p CNKSR1 -3.87258704301474 1.22658629378451e-80 1.44823291536679 2.12293533329982e-27 miRanda -0.215811376927085 2.72390783827711e-26 NA NA NA hsa-miR-375 CNKSR2 2.09893673049766 1.68351780396203e-16 -3.49949785208655 1.01602507278623e-50 miRanda -0.349065238847428 4.76518398813731e-28 NA NA NA hsa-miR-182-5p CNN3 2.36408084103818 2.60011457600281e-72 -0.430464499015071 9.32927212002364e-06 MirTarget -0.148911703926272 9.68451187941917e-11 NA NA NA hsa-miR-200b-3p CNN3 2.11744072703209 1.66710572104191e-43 -0.430464499015071 9.32927212002364e-06 MirTarget;TargetScan -0.114275940199066 2.67775221206774e-08 NA NA NA hsa-miR-200c-3p CNN3 2.07038651806183 6.84613386286599e-51 -0.430464499015071 9.32927212002364e-06 MirTarget;miRNATAP -0.159482264721371 1.26165223474504e-12 NA NA NA hsa-miR-96-5p CNN3 3.24596558166606 1.92296159041707e-98 -0.430464499015071 9.32927212002364e-06 MirTarget;TargetScan;miRNATAP -0.136753021641737 6.79887580153868e-13 NA NA NA hsa-miR-429 CNNM1 2.84108892259147 3.88520896426515e-64 -2.03023791736818 3.19718601839217e-15 miRanda;miRNATAP -0.216279018641674 1.23962516204177e-05 NA NA NA hsa-miR-486-5p CNNM4 -3.87258704301474 1.22658629378451e-80 0.645220495821336 2.53231625503454e-14 miRanda -0.102618099541159 1.3757005774402e-15 NA NA NA hsa-miR-139-5p CNPY2 -3.25846663863766 2.62018989415003e-112 0.776781347614628 5.134868354468e-30 miRanda -0.151698343675156 5.41879648554694e-27 NA NA NA hsa-miR-21-3p CNRIP1 2.17476065946878 5.15299442583591e-75 -1.6721946883908 3.98165243204626e-54 MirTarget -0.29373502893326 3.49738870112531e-23 NA NA NA hsa-miR-375 CNRIP1 2.09893673049766 1.68351780396203e-16 -1.6721946883908 3.98165243204626e-54 miRanda -0.112022644304228 8.93881769885715e-14 NA NA NA hsa-miR-511-5p CNTD1 -2.27545475897362 3.84085514050558e-36 0.0904823634000029 0.482506165006642 MirTarget -0.167310910659875 4.7073569584412e-13 NA NA NA hsa-miR-335-5p CNTD2 -2.61355235628987 2.6462884165886e-51 2.71473767156024 4.52066075073536e-30 miRNAWalker2_validate -0.273443819554615 1.95756179123131e-09 NA NA NA hsa-miR-200b-3p CNTFR 2.11744072703209 1.66710572104191e-43 -4.18061105410292 1.90682468942591e-39 TargetScan -0.554791324000155 1.82863912924816e-15 NA NA NA hsa-miR-200c-3p CNTFR 2.07038651806183 6.84613386286599e-51 -4.18061105410292 1.90682468942591e-39 miRNATAP -0.651234543642083 1.71163355931122e-17 NA NA NA hsa-miR-21-5p CNTFR 2.32007501846389 3.08394781855554e-137 -4.18061105410292 1.90682468942591e-39 miRNATAP -1.1291637732312 3.37574589247041e-29 NA NA NA hsa-miR-429 CNTFR 2.84108892259147 3.88520896426515e-64 -4.18061105410292 1.90682468942591e-39 PITA;miRanda;miRNATAP -0.572643184326223 2.19667161306476e-20 NA NA NA hsa-miR-429 CNTLN 2.84108892259147 3.88520896426515e-64 -0.708859371463235 7.45603151438028e-11 miRanda;miRNATAP -0.136855983030805 3.28065153831596e-11 NA NA NA hsa-miR-141-3p CNTN1 2.99777540204168 1.26370498493024e-78 -2.29693171558319 8.43646057960019e-19 MirTarget;TargetScan;miRNATAP -0.520810849287513 2.4730276902971e-25 NA NA NA hsa-miR-182-5p CNTN1 2.36408084103818 2.60011457600281e-72 -2.29693171558319 8.43646057960019e-19 MirTarget;miRNATAP -0.445936957395469 9.02356735197456e-13 NA NA NA hsa-miR-200a-3p CNTN1 2.55218480823434 2.96135446816238e-51 -2.29693171558319 8.43646057960019e-19 MirTarget;miRNATAP -0.448173424296059 1.39139352339811e-19 NA NA NA hsa-miR-200b-3p CNTN1 2.11744072703209 1.66710572104191e-43 -2.29693171558319 8.43646057960019e-19 MirTarget -0.443481986404126 1.12213776002377e-15 NA NA NA hsa-miR-200c-3p CNTN1 2.07038651806183 6.84613386286599e-51 -2.29693171558319 8.43646057960019e-19 MirTarget;miRNATAP -0.486655215389096 1.29219201353698e-15 NA NA NA hsa-miR-429 CNTN1 2.84108892259147 3.88520896426515e-64 -2.29693171558319 8.43646057960019e-19 MirTarget;miRNATAP -0.445764592915726 1.22605246734741e-19 NA NA NA hsa-miR-96-5p CNTN1 3.24596558166606 1.92296159041707e-98 -2.29693171558319 8.43646057960019e-19 miRNATAP -0.54617655432043 6.18617663784008e-27 NA NA NA hsa-miR-200b-3p CNTN4 2.11744072703209 1.66710572104191e-43 -1.67531059692434 2.00125518995555e-14 TargetScan -0.262665574307442 2.1312394950109e-08 NA NA NA hsa-miR-200c-3p CNTN4 2.07038651806183 6.84613386286599e-51 -1.67531059692434 2.00125518995555e-14 miRNATAP -0.354167231970875 5.17596993122049e-12 NA NA NA hsa-miR-429 CNTN4 2.84108892259147 3.88520896426515e-64 -1.67531059692434 2.00125518995555e-14 PITA;miRanda;miRNATAP -0.325891405540306 4.10992662870441e-15 NA NA NA hsa-miR-429 CNTNAP3 2.84108892259147 3.88520896426515e-64 -3.68489538533331 8.13036816426595e-50 miRanda -0.407738692084601 1.16739496479694e-16 NA NA NA hsa-miR-21-3p COBL 2.17476065946878 5.15299442583591e-75 -0.145502577420459 0.386167299174053 MirTarget -0.155378223100414 0.000428008106068051 NA NA NA hsa-miR-21-3p COBLL1 2.17476065946878 5.15299442583591e-75 -1.51374445109298 4.11446578627917e-38 mirMAP -0.182787195026657 1.28360702063614e-08 NA NA NA hsa-miR-21-5p COBLL1 2.32007501846389 3.08394781855554e-137 -1.51374445109298 4.11446578627917e-38 miRNAWalker2_validate -0.403337507435837 1.61465967789367e-27 NA NA NA hsa-miR-429 COBLL1 2.84108892259147 3.88520896426515e-64 -1.51374445109298 4.11446578627917e-38 miRanda -0.242992313956555 4.82644445528246e-27 NA NA NA hsa-miR-335-5p COL10A1 -2.61355235628987 2.6462884165886e-51 7.00264694164977 1.81943635502338e-136 miRNAWalker2_validate -0.757712035266228 2.37599244577388e-37 NA NA NA hsa-miR-139-5p COL11A1 -3.25846663863766 2.62018989415003e-112 5.98557038029313 1.10741703125517e-74 miRanda -1.31747531356369 1.32600752122946e-87 NA NA NA hsa-miR-335-5p COL11A1 -2.61355235628987 2.6462884165886e-51 5.98557038029313 1.10741703125517e-74 miRNAWalker2_validate -0.781512756031571 4.22709692413003e-34 NA NA NA hsa-miR-486-5p COL13A1 -3.87258704301474 1.22658629378451e-80 1.34121772704738 1.38388805507548e-16 miRanda -0.143998063604167 7.74919341465794e-09 NA NA NA hsa-miR-141-3p COL15A1 2.99777540204168 1.26370498493024e-78 -0.803401987255061 2.68368384262364e-13 MirTarget -0.283251109809767 3.53569331248087e-43 NA NA NA hsa-miR-200a-3p COL15A1 2.55218480823434 2.96135446816238e-51 -0.803401987255061 2.68368384262364e-13 MirTarget -0.239541084377907 1.33609062706718e-31 NA NA NA hsa-miR-429 COL21A1 2.84108892259147 3.88520896426515e-64 -1.27446283655995 1.8119467231132e-11 miRanda -0.22002974243237 1.04912680547558e-09 NA NA NA hsa-miR-429 COL23A1 2.84108892259147 3.88520896426515e-64 -1.01578101863477 7.99672204579863e-10 miRanda -0.115350649445982 0.000259876384429219 NA NA NA hsa-miR-429 COL25A1 2.84108892259147 3.88520896426515e-64 -3.50736717261989 7.11915422886516e-71 miRanda -0.516985865287557 2.39834848583411e-40 NA NA NA hsa-miR-96-5p COL25A1 3.24596558166606 1.92296159041707e-98 -3.50736717261989 7.11915422886516e-71 TargetScan -0.584124925831509 7.22824551894665e-48 NA NA NA hsa-miR-141-5p COL3A1 2.38411349683216 4.56310582620282e-58 1.50470077229731 1.9069386527602e-18 MirTarget -0.108970969526337 0.00383111381765932 NA NA NA hsa-miR-335-5p COL3A1 -2.61355235628987 2.6462884165886e-51 1.50470077229731 1.9069386527602e-18 miRNAWalker2_validate -0.177478192997637 4.26024104803443e-08 NA NA NA hsa-miR-429 COL4A1 2.84108892259147 3.88520896426515e-64 -0.0605089402704468 0.561130598229782 miRanda;miRNATAP -0.117661971659563 1.69676712956939e-09 NA NA NA hsa-miR-200b-3p COL4A3 2.11744072703209 1.66710572104191e-43 -2.06982209902333 2.89268812766655e-17 TargetScan -0.138361560009036 0.00908463546638511 NA NA NA hsa-miR-200c-3p COL4A3 2.07038651806183 6.84613386286599e-51 -2.06982209902333 2.89268812766655e-17 miRNATAP -0.114703755043262 0.0494045001394077 NA NA NA hsa-miR-429 COL4A3 2.84108892259147 3.88520896426515e-64 -2.06982209902333 2.89268812766655e-17 miRanda;miRNATAP -0.182052452818027 0.00011657104661419 NA NA NA hsa-miR-200b-3p COL4A3BP 2.11744072703209 1.66710572104191e-43 -1.01912082714167 3.26023326678508e-38 MirTarget;TargetScan -0.178803495723155 7.28179874882863e-26 NA NA NA hsa-miR-200c-3p COL4A3BP 2.07038651806183 6.84613386286599e-51 -1.01912082714167 3.26023326678508e-38 MirTarget -0.216917715845884 1.44515846406771e-31 NA NA NA hsa-miR-429 COL4A3BP 2.84108892259147 3.88520896426515e-64 -1.01912082714167 3.26023326678508e-38 MirTarget;miRanda;miRNATAP -0.185271187377767 4.80714849989469e-35 NA NA NA hsa-miR-182-5p COL4A4 2.36408084103818 2.60011457600281e-72 -1.19780850940918 1.1373009393889e-10 MirTarget -0.336060797774185 2.60983267806506e-14 NA NA NA hsa-miR-429 COL4A4 2.84108892259147 3.88520896426515e-64 -1.19780850940918 1.1373009393889e-10 miRNATAP -0.12335076045166 0.000521126476669951 NA NA NA hsa-miR-429 COL4A6 2.84108892259147 3.88520896426515e-64 -2.60404497415182 4.59834952999788e-22 miRanda;miRNATAP -0.301737950731445 6.80185259616497e-09 NA NA NA hsa-miR-96-5p COL4A6 3.24596558166606 1.92296159041707e-98 -2.60404497415182 4.59834952999788e-22 TargetScan -0.358638324372274 3.60799197577596e-11 NA NA NA hsa-miR-335-5p COL5A2 -2.61355235628987 2.6462884165886e-51 1.6351443104017 5.84941071703082e-26 miRNATAP -0.189745531336072 1.18936540997693e-10 NA NA NA hsa-miR-429 COL5A3 2.84108892259147 3.88520896426515e-64 0.260939522601073 0.0725025833072133 miRanda -0.143378228864796 1.60527154004706e-07 NA NA NA hsa-miR-335-5p COL6A1 -2.61355235628987 2.6462884165886e-51 0.502660048227115 0.000176004058519763 miRNAWalker2_validate -0.113562051975344 4.99241838822059e-06 NA NA NA hsa-miR-429 COL6A3 2.84108892259147 3.88520896426515e-64 0.634653480531805 2.31261246968383e-05 miRNATAP -0.156049616870907 3.65967820567379e-08 NA NA NA hsa-miR-375 COL6A6 2.09893673049766 1.68351780396203e-16 -4.13623144944441 2.15085613287136e-58 miRanda -0.280960121016173 5.00098926026836e-15 NA NA NA hsa-miR-429 COL6A6 2.84108892259147 3.88520896426515e-64 -4.13623144944441 2.15085613287136e-58 miRanda -0.565610558287695 5.3336432223487e-29 NA NA NA hsa-miR-141-3p COL8A1 2.99777540204168 1.26370498493024e-78 0.811494509913119 3.40026721855729e-06 mirMAP -0.153417512297445 6.50997102751889e-06 NA NA NA hsa-miR-200a-3p COL8A1 2.55218480823434 2.96135446816238e-51 0.811494509913119 3.40026721855729e-06 mirMAP -0.161874172718556 1.21029470085196e-06 NA NA NA hsa-miR-335-5p COL8A2 -2.61355235628987 2.6462884165886e-51 0.331058696879189 0.0275530814582222 miRNAWalker2_validate -0.129867965752422 3.01390660648351e-06 NA NA NA hsa-miR-335-5p COL9A2 -2.61355235628987 2.6462884165886e-51 0.765612393916573 0.000156825908929372 miRNAWalker2_validate -0.170476149910631 5.85079319606979e-06 NA NA NA hsa-miR-335-5p COL9A3 -2.61355235628987 2.6462884165886e-51 0.937179586048349 0.000732672788450644 miRNAWalker2_validate -0.285342670699414 2.74513332001203e-08 NA NA NA hsa-miR-486-5p COL9A3 -3.87258704301474 1.22658629378451e-80 0.937179586048349 0.000732672788450644 miRanda -0.109450786795404 0.00965430825486021 NA NA NA hsa-miR-139-5p COMMD3 -3.25846663863766 2.62018989415003e-112 0.675388089068306 6.93374609568002e-19 miRanda -0.130598715925741 9.31244938796307e-17 NA NA NA hsa-miR-145-5p COMMD5 -2.62703571936687 7.64402900188551e-88 1.01520256885491 1.90507768979168e-40 MirTarget -0.221115148996679 2.66445262645184e-35 NA NA NA hsa-miR-10b-5p COPS5 -2.10996264627796 7.36811595736367e-72 0.51480608986758 2.83486894958876e-14 miRNAWalker2_validate -0.158725408499968 8.31021097418263e-19 NA NA NA hsa-miR-10b-5p COPS7B -2.10996264627796 7.36811595736367e-72 0.260922741675057 8.54681067505874e-08 MirTarget -0.125827582497466 3.59242576929668e-23 NA NA NA hsa-miR-99a-5p COQ2 -2.25079447371102 1.14086813185885e-54 0.458915303363875 1.04719604940293e-10 miRNAWalker2_validate -0.125554249977758 9.45246968100722e-16 NA NA NA hsa-miR-224-5p COQ7 -2.22249420723892 1.07787949391113e-18 0.201465197240743 0.00510446723254919 mirMAP -0.114022110328958 1.59412853881212e-35 NA NA NA hsa-miR-486-5p CORIN -3.87258704301474 1.22658629378451e-80 2.00447485032 9.16990923981099e-21 miRanda -0.361121226125607 4.74881551326079e-29 NA NA NA hsa-miR-141-3p CORO1C 2.99777540204168 1.26370498493024e-78 -0.57046570422146 8.71993218248989e-15 TargetScan -0.133452343069201 4.81951215741389e-21 NA NA NA hsa-miR-182-5p CORO1C 2.36408084103818 2.60011457600281e-72 -0.57046570422146 8.71993218248989e-15 MirTarget;miRNATAP -0.202031105000404 4.07612740609636e-32 NA NA NA hsa-miR-200b-3p CORO1C 2.11744072703209 1.66710572104191e-43 -0.57046570422146 8.71993218248989e-15 MirTarget;TargetScan -0.168053875264079 5.76235963121156e-28 NA NA NA hsa-miR-200c-3p CORO1C 2.07038651806183 6.84613386286599e-51 -0.57046570422146 8.71993218248989e-15 MirTarget;miRNATAP -0.174250149922637 7.44833485989281e-25 NA NA NA hsa-miR-375 CORO1C 2.09893673049766 1.68351780396203e-16 -0.57046570422146 8.71993218248989e-15 miRNAWalker2_validate -0.12263783027835 6.04558770392321e-39 NA NA NA hsa-miR-429 CORO1C 2.84108892259147 3.88520896426515e-64 -0.57046570422146 8.71993218248989e-15 MirTarget;PITA;miRanda;miRNATAP -0.111130267332005 1.38936424657312e-15 NA NA NA hsa-miR-96-5p CORO1C 3.24596558166606 1.92296159041707e-98 -0.57046570422146 8.71993218248989e-15 TargetScan;miRNATAP -0.147455446786091 9.00241338271669e-25 NA NA NA hsa-miR-210-3p CORO2B 2.38367203491819 3.73261999106754e-22 -2.59592071902654 1.66599959996356e-66 MirTarget -0.29894038825684 4.02155186736468e-46 NA NA NA hsa-miR-429 CORO2B 2.84108892259147 3.88520896426515e-64 -2.59592071902654 1.66599959996356e-66 miRNATAP -0.478487602289855 2.90959163383058e-62 NA NA NA hsa-miR-335-5p CORO7 -2.61355235628987 2.6462884165886e-51 0.9443103348191 1.05635903920381e-34 miRNAWalker2_validate -0.124073899378026 2.00715254254256e-17 NA NA NA hsa-miR-375 CP 2.09893673049766 1.68351780396203e-16 -1.67217844088781 1.34727302241253e-05 miRanda -0.442494373718394 7.25966583414107e-19 NA NA NA hsa-miR-429 CPE 2.84108892259147 3.88520896426515e-64 -1.2306475289771 6.06559656904635e-18 miRanda -0.264661954056953 6.75283545887745e-23 NA NA NA hsa-miR-182-5p CPEB1 2.36408084103818 2.60011457600281e-72 -2.57128181037364 6.48452220778867e-39 miRNATAP -0.405878723660562 5.0619786866338e-17 NA NA NA hsa-miR-183-5p CPEB1 2.95681814393872 1.09965777344285e-92 -2.57128181037364 6.48452220778867e-39 miRNATAP -0.428520974698001 5.35400222425583e-24 NA NA NA hsa-miR-375 CPEB1 2.09893673049766 1.68351780396203e-16 -2.57128181037364 6.48452220778867e-39 miRanda -0.101732255089729 0.000187786847392762 NA NA NA hsa-miR-429 CPEB1 2.84108892259147 3.88520896426515e-64 -2.57128181037364 6.48452220778867e-39 miRNATAP -0.423597450616747 4.7804430820051e-29 NA NA NA hsa-miR-96-5p CPEB1 3.24596558166606 1.92296159041707e-98 -2.57128181037364 6.48452220778867e-39 MirTarget;TargetScan;miRNATAP -0.47089216215103 4.7605746567602e-33 NA NA NA hsa-miR-210-3p CPEB2 2.38367203491819 3.73261999106754e-22 -0.298345623194636 0.0154801715002403 miRNAWalker2_validate;miRTarBase -0.116847775246232 1.35453016716026e-12 NA NA NA hsa-miR-21-5p CPEB3 2.32007501846389 3.08394781855554e-137 -0.801584198350877 2.29522439524916e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.335010077484093 7.2508091850588e-33 NA NA NA hsa-miR-21-3p CPEB4 2.17476065946878 5.15299442583591e-75 -0.464491870392757 1.88835017434784e-05 mirMAP -0.101559396282933 0.000394917453137599 NA NA NA hsa-miR-429 CPEB4 2.84108892259147 3.88520896426515e-64 -0.464491870392757 1.88835017434784e-05 miRNATAP -0.107022281892516 1.86787228507778e-07 NA NA NA hsa-miR-378a-5p CPLX2 -2.43173551693523 1.44932837789175e-68 1.27366078086392 0.00038896895909928 mirMAP -0.385607707513101 2.04226996307121e-06 NA NA NA hsa-miR-196a-5p CPM 2.33423717464504 3.646557504928e-18 -1.86998255407086 2.3046292197309e-45 miRNATAP -0.132260885803123 1.50290270931294e-14 NA NA NA hsa-miR-375 CPM 2.09893673049766 1.68351780396203e-16 -1.86998255407086 2.3046292197309e-45 miRanda -0.122363029188272 2.11081648785383e-11 NA NA NA hsa-miR-429 CPNE2 2.84108892259147 3.88520896426515e-64 -0.812222252064754 2.78826121763128e-23 miRanda -0.12714815941962 4.12233793169875e-16 NA NA NA hsa-miR-375 CPNE8 2.09893673049766 1.68351780396203e-16 -1.3845742448351 1.45815071649029e-28 miRanda;miRNATAP -0.193445325318429 4.65847148522686e-32 NA NA NA hsa-miR-429 CPNE8 2.84108892259147 3.88520896426515e-64 -1.3845742448351 1.45815071649029e-28 miRanda -0.239378952441606 9.80832898790557e-24 NA NA NA hsa-miR-183-5p CR1 2.95681814393872 1.09965777344285e-92 -1.98176372901688 3.19324999435849e-18 miRNAWalker2_validate -0.408215035459729 2.15973281639865e-17 NA NA NA hsa-miR-429 CR1 2.84108892259147 3.88520896426515e-64 -1.98176372901688 3.19324999435849e-18 miRanda -0.347239314411635 1.12981694547202e-15 NA NA NA hsa-miR-335-5p CRB3 -2.61355235628987 2.6462884165886e-51 2.4091846997205 1.11094675131068e-63 miRNAWalker2_validate -0.297219369644131 1.84019519189904e-26 NA NA NA hsa-miR-141-3p CREB5 2.99777540204168 1.26370498493024e-78 -2.34983683376521 9.5898827522032e-62 mirMAP -0.420728186922246 3.61586637494311e-51 NA NA NA hsa-miR-182-5p CREB5 2.36408084103818 2.60011457600281e-72 -2.34983683376521 9.5898827522032e-62 mirMAP -0.489369301103731 1.31250062187772e-45 NA NA NA hsa-miR-200a-3p CREB5 2.55218480823434 2.96135446816238e-51 -2.34983683376521 9.5898827522032e-62 mirMAP -0.329840324236737 9.82195063284642e-32 NA NA NA hsa-miR-200b-3p CREB5 2.11744072703209 1.66710572104191e-43 -2.34983683376521 9.5898827522032e-62 TargetScan -0.364418430782804 2.65438137279006e-31 NA NA NA hsa-miR-200c-3p CREB5 2.07038651806183 6.84613386286599e-51 -2.34983683376521 9.5898827522032e-62 miRNATAP -0.482139236249271 2.9707359635911e-46 NA NA NA hsa-miR-21-3p CREB5 2.17476065946878 5.15299442583591e-75 -2.34983683376521 9.5898827522032e-62 mirMAP -0.269944075717791 1.31071184087826e-11 NA NA NA hsa-miR-429 CREB5 2.84108892259147 3.88520896426515e-64 -2.34983683376521 9.5898827522032e-62 PITA;miRanda;miRNATAP -0.314986461501622 2.7535498159881e-29 NA NA NA hsa-miR-361-5p CREBBP -0.0996867547900457 0.095428250126326 -0.207546077707359 0.000564449557347142 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 NA NA NA hsa-miR-374a-3p CREBBP 0.34122393953022 2.28714105382856e-05 -0.207546077707359 0.000564449557347142 miRNATAP -0.118175129899399 3.92114134022804e-06 NA NA NA hsa-miR-590-3p CREBBP 1.27438512890514 1.03164723481469e-23 -0.207546077707359 0.000564449557347142 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 NA NA NA hsa-miR-21-3p CREBL2 2.17476065946878 5.15299442583591e-75 -0.828924810318552 7.72831390224407e-35 MirTarget -0.20451005391755 1.69665928676133e-30 NA NA NA hsa-miR-21-5p CREBL2 2.32007501846389 3.08394781855554e-137 -0.828924810318552 7.72831390224407e-35 miRNATAP -0.28472177536481 8.10741363566585e-43 NA NA NA hsa-miR-429 CREBL2 2.84108892259147 3.88520896426515e-64 -0.828924810318552 7.72831390224407e-35 PITA;miRanda;miRNATAP -0.151855728340183 1.55567101408978e-32 NA NA NA hsa-miR-200b-3p CRHBP 2.11744072703209 1.66710572104191e-43 -3.66581217736436 6.35220493058743e-83 MirTarget -0.59409091405194 1.28495550342245e-44 NA NA NA hsa-miR-200c-3p CRHBP 2.07038651806183 6.84613386286599e-51 -3.66581217736436 6.35220493058743e-83 MirTarget -0.750667430746763 9.48311945356719e-61 NA NA NA hsa-miR-429 CRHBP 2.84108892259147 3.88520896426515e-64 -3.66581217736436 6.35220493058743e-83 MirTarget;PITA;miRanda;miRNATAP -0.571078138926882 1.92952861600466e-52 NA NA NA hsa-miR-200a-5p CRIM1 2.58844508672328 1.79650654234569e-56 -2.02664077447827 3.91244764943777e-56 MirTarget -0.195100710199915 2.0009034913784e-13 NA NA NA hsa-miR-21-5p CRIM1 2.32007501846389 3.08394781855554e-137 -2.02664077447827 3.91244764943777e-56 miRNATAP -0.601861660496863 2.85407244426875e-50 NA NA NA hsa-miR-429 CRIM1 2.84108892259147 3.88520896426515e-64 -2.02664077447827 3.91244764943777e-56 miRanda -0.249746035148686 9.22934006662873e-23 NA NA NA hsa-miR-335-5p CRIP2 -2.61355235628987 2.6462884165886e-51 0.817713792104723 1.77306844892583e-10 miRNAWalker2_validate -0.109733426710463 4.73476324208731e-06 NA NA NA hsa-miR-139-5p CRISP3 -3.25846663863766 2.62018989415003e-112 1.47382568470891 0.000527659301751358 miRanda -0.249055070097779 0.00455503008010282 NA NA NA hsa-miR-375 CRISPLD1 2.09893673049766 1.68351780396203e-16 -1.88756141169747 8.99779553823236e-17 miRanda -0.257158420874287 8.75797086933372e-18 NA NA NA hsa-miR-429 CRISPLD1 2.84108892259147 3.88520896426515e-64 -1.88756141169747 8.99779553823236e-17 miRanda;miRNATAP -0.247333386213207 1.32580952837541e-08 NA NA NA hsa-miR-96-5p CRISPLD1 3.24596558166606 1.92296159041707e-98 -1.88756141169747 8.99779553823236e-17 TargetScan -0.458462468804916 6.22326002834007e-25 NA NA NA hsa-miR-182-5p CRISPLD2 2.36408084103818 2.60011457600281e-72 0.105622734256196 0.425091936416587 mirMAP -0.123909917832035 8.17673716458007e-05 NA NA NA hsa-miR-375 CRLF1 2.09893673049766 1.68351780396203e-16 -0.419734141417057 0.0758779195829251 miRNAWalker2_validate -0.105784528285738 0.000686867816230096 NA NA NA hsa-miR-141-3p CRMP1 2.99777540204168 1.26370498493024e-78 -0.337869523464731 0.012350492740263 MirTarget;TargetScan -0.128583387083388 8.74536586439782e-07 NA NA NA hsa-miR-200b-3p CRTAP 2.11744072703209 1.66710572104191e-43 -0.981682928574237 1.61266249905263e-58 TargetScan -0.229725630746709 1.15487150061672e-73 NA NA NA hsa-miR-429 CRTAP 2.84108892259147 3.88520896426515e-64 -0.981682928574237 1.61266249905263e-58 PITA;miRanda;miRNATAP -0.210298358860701 3.41971255631513e-78 NA NA NA hsa-miR-21-5p CRTC3 2.32007501846389 3.08394781855554e-137 -0.319238572421465 3.75830243452802e-10 mirMAP -0.11499602708942 3.24511730045584e-13 NA NA NA hsa-miR-141-3p CRYBG3 2.99777540204168 1.26370498493024e-78 -2.30356586227424 2.15606739484442e-47 MirTarget -0.442346327650811 5.16748105687821e-46 NA NA NA hsa-miR-200a-3p CRYBG3 2.55218480823434 2.96135446816238e-51 -2.30356586227424 2.15606739484442e-47 MirTarget -0.377237192803923 3.61747279589422e-34 NA NA NA hsa-miR-200c-3p CRYBG3 2.07038651806183 6.84613386286599e-51 -2.30356586227424 2.15606739484442e-47 miRNATAP -0.489778998387332 9.99423588006057e-39 NA NA NA hsa-miR-375 CRYBG3 2.09893673049766 1.68351780396203e-16 -2.30356586227424 2.15606739484442e-47 miRNATAP -0.168366398585914 1.81084368625278e-14 NA NA NA hsa-miR-429 CRYBG3 2.84108892259147 3.88520896426515e-64 -2.30356586227424 2.15606739484442e-47 miRNATAP -0.364852757466619 2.42624283951935e-32 NA NA NA hsa-miR-429 CSF1 2.84108892259147 3.88520896426515e-64 -1.08800144751585 6.47455154417147e-21 PITA;miRanda;miRNATAP -0.19084665356121 5.34746781839834e-18 NA NA NA hsa-miR-96-5p CSF1 3.24596558166606 1.92296159041707e-98 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.252185993359345 1.25546616030164e-28 NA NA NA hsa-miR-429 CSF2RA 2.84108892259147 3.88520896426515e-64 -0.427721480711688 0.000486382339897373 miRanda -0.100259679514765 1.5609930264171e-05 NA NA NA hsa-miR-141-3p CSF3 2.99777540204168 1.26370498493024e-78 -3.88687956855714 5.79181068171002e-45 TargetScan;miRNATAP -0.635639647527127 3.84247648434209e-31 NA NA NA hsa-miR-200a-3p CSF3 2.55218480823434 2.96135446816238e-51 -3.88687956855714 5.79181068171002e-45 miRNATAP -0.476735635349525 2.71347727473529e-18 NA NA NA hsa-miR-183-5p CSMD1 2.95681814393872 1.09965777344285e-92 -2.28009826582218 1.88084363200973e-15 MirTarget -0.463302792011628 2.16327304759268e-14 NA NA NA hsa-miR-429 CSMD1 2.84108892259147 3.88520896426515e-64 -2.28009826582218 1.88084363200973e-15 miRanda;miRNATAP -0.322431468457697 4.23305731007765e-09 NA NA NA hsa-miR-139-3p CSMD2 -3.44089023199323 1.67292890850702e-91 1.79770612193453 1.73584350020955e-21 MirTarget -0.323257206028112 2.78255652469887e-21 NA NA NA hsa-miR-486-5p CSMD2 -3.87258704301474 1.22658629378451e-80 1.79770612193453 1.73584350020955e-21 miRanda -0.199755309133065 6.6723068291989e-12 NA NA NA hsa-miR-452-5p CSMD3 -2.48486455572568 1.24430987974325e-33 0.411886636884206 0.171316257883655 MirTarget -0.222265774672966 3.51928131100354e-06 NA NA NA hsa-miR-107 CSNK1A1 0.678998026350662 2.56224148930538e-16 0.188208571372272 0.000892405027068843 PITA;miRanda;miRNATAP -0.122179164718018 1.10059616048406e-07 NA NA NA hsa-miR-155-5p CSNK1A1 1.09766314984151 4.55650930885814e-15 0.188208571372272 0.000892405027068843 miRNAWalker2_validate;miRTarBase;miRNATAP -0.112093319289922 5.71697685710134e-17 NA NA NA hsa-miR-17-5p CSNK1A1 0.599531757298529 1.07318660415906e-05 0.188208571372272 0.000892405027068843 TargetScan -0.139354338789202 6.20716702675882e-24 NA NA NA hsa-miR-186-5p CSNK1A1 -0.426987301460247 1.04129380549315e-05 0.188208571372272 0.000892405027068843 miRNAWalker2_validate;miRNATAP -0.111953585604854 1.83989613326677e-08 NA NA NA hsa-miR-19a-3p CSNK1A1 0.817507952171848 3.76285090469625e-08 0.188208571372272 0.000892405027068843 mirMAP -0.108764735747862 1.2137097303677e-17 NA NA NA hsa-miR-19b-3p CSNK1A1 0.139124391010031 0.255658553872934 0.188208571372272 0.000892405027068843 mirMAP -0.113820613941943 4.04480731084776e-13 NA NA NA hsa-miR-30e-5p CSNK1A1 0.293491764699475 0.000372291967271834 0.188208571372272 0.000892405027068843 MirTarget -0.118629602890873 4.59975508016632e-07 NA NA NA hsa-miR-501-3p CSNK1A1 0.0448022813406874 0.711710441403614 0.188208571372272 0.000892405027068843 TargetScan;miRNATAP -0.102750322971741 1.05636462078204e-10 NA NA NA hsa-miR-502-3p CSNK1A1 0.11461741546458 0.276553832470138 0.188208571372272 0.000892405027068843 miRNATAP -0.176013262432281 1.80237661044146e-22 NA NA NA hsa-miR-576-5p CSNK1A1 0.0649387707567879 0.588791966096287 0.188208571372272 0.000892405027068843 mirMAP -0.103328281253168 1.20036851836147e-10 NA NA NA hsa-miR-652-3p CSNK1A1 -0.271945538531539 0.0202845718784411 0.188208571372272 0.000892405027068843 miRNAWalker2_validate -0.106904286901307 7.62564332600731e-11 NA NA NA hsa-let-7a-5p CSNK2A1 -0.210286642041636 0.0072546234707717 0.308188225977895 5.2689466399312e-07 miRNAWalker2_validate;TargetScan -0.135347217436861 5.73489571379612e-07 NA NA NA hsa-let-7c-5p CSNK2A1 -1.9415540533505 9.55250745007793e-48 0.308188225977895 5.2689466399312e-07 miRNAWalker2_validate -0.112963831397893 1.45380762126855e-14 NA NA NA hsa-miR-143-3p CSNK2A1 -1.23248181631499 4.74160976678504e-28 0.308188225977895 5.2689466399312e-07 MirTarget -0.102863413291093 1.39184437094928e-08 NA NA NA hsa-miR-26a-5p CSNK2A1 -0.481180084102235 1.82368246174758e-10 0.308188225977895 5.2689466399312e-07 mirMAP -0.183032285298427 3.80367876396133e-11 NA NA NA hsa-miR-96-5p CSRNP1 3.24596558166606 1.92296159041707e-98 -1.64790118181322 1.11688501051482e-52 MirTarget;TargetScan;miRNATAP -0.283276716653292 8.06898437562415e-39 NA NA NA hsa-miR-182-5p CSRNP3 2.36408084103818 2.60011457600281e-72 -3.01553219063623 2.41616502431045e-41 miRNATAP -0.472412890771556 1.03802596686725e-17 NA NA NA hsa-miR-200a-5p CSRNP3 2.58844508672328 1.79650654234569e-56 -3.01553219063623 2.41616502431045e-41 miRNATAP -0.330224103743101 3.7349237417394e-13 NA NA NA hsa-miR-200b-3p CSRNP3 2.11744072703209 1.66710572104191e-43 -3.01553219063623 2.41616502431045e-41 MirTarget;TargetScan -0.390351341608898 2.18846471132251e-15 NA NA NA hsa-miR-200c-3p CSRNP3 2.07038651806183 6.84613386286599e-51 -3.01553219063623 2.41616502431045e-41 MirTarget;miRNATAP -0.418435034601253 1.13548933902e-14 NA NA NA hsa-miR-21-5p CSRNP3 2.32007501846389 3.08394781855554e-137 -3.01553219063623 2.41616502431045e-41 miRNATAP -0.727152198067792 2.6305143833534e-24 NA NA NA hsa-miR-429 CSRNP3 2.84108892259147 3.88520896426515e-64 -3.01553219063623 2.41616502431045e-41 MirTarget;miRNATAP -0.409200002194121 6.74015872719225e-21 NA NA NA hsa-miR-96-5p CSRNP3 3.24596558166606 1.92296159041707e-98 -3.01553219063623 2.41616502431045e-41 TargetScan;miRNATAP -0.493024657645752 8.91064726881989e-28 NA NA NA hsa-miR-335-5p CST1 -2.61355235628987 2.6462884165886e-51 7.09664461506414 8.00575883110561e-62 miRNAWalker2_validate -0.658233807862541 7.40697004727806e-15 NA NA NA hsa-miR-452-5p CST1 -2.48486455572568 1.24430987974325e-33 7.09664461506414 8.00575883110561e-62 MirTarget -0.670093357802353 1.81952329773778e-20 NA NA NA hsa-miR-335-5p CST2 -2.61355235628987 2.6462884165886e-51 4.49127322087832 5.46693304634874e-45 miRNAWalker2_validate -0.301179881396345 1.4231991688162e-06 NA NA NA hsa-miR-335-5p CST4 -2.61355235628987 2.6462884165886e-51 5.06353074086012 2.87748998288278e-42 miRNAWalker2_validate -0.466930061656099 9.3836183428549e-11 NA NA NA hsa-miR-452-5p CST5 -2.48486455572568 1.24430987974325e-33 2.69475600281926 1.23769561344738e-10 MirTarget -0.752071633068046 1.05784681317653e-30 NA NA NA hsa-miR-335-5p CST6 -2.61355235628987 2.6462884165886e-51 2.18164028007977 7.56968879795512e-19 miRNAWalker2_validate -0.256153729151954 3.46776236540638e-08 NA NA NA hsa-miR-141-3p CSTA 2.99777540204168 1.26370498493024e-78 -1.16695336107157 1.13881557219886e-09 MirTarget -0.167586821932582 7.87345552949921e-06 NA NA NA hsa-miR-200a-3p CSTA 2.55218480823434 2.96135446816238e-51 -1.16695336107157 1.13881557219886e-09 MirTarget -0.216364868104157 3.49938925677905e-09 NA NA NA hsa-miR-139-5p CSTF3 -3.25846663863766 2.62018989415003e-112 0.654464844781528 1.22382817704603e-33 PITA;miRanda -0.14826115164283 2.80518824054453e-41 NA NA NA hsa-miR-145-5p CSTF3 -2.62703571936687 7.64402900188551e-88 0.654464844781528 1.22382817704603e-33 MirTarget -0.13081355557103 7.26808258897427e-25 NA NA NA hsa-miR-10b-5p CTBP1 -2.10996264627796 7.36811595736367e-72 0.443725972486773 2.72881965678652e-14 miRNAWalker2_validate -0.131124284874422 2.1818976824128e-17 NA NA NA hsa-miR-1271-5p CTBP1 -1.08290983583835 3.85149976357318e-12 0.443725972486773 2.72881965678652e-14 mirMAP -0.118815949476465 5.57969791453083e-21 NA NA NA hsa-miR-409-3p CTBP1 -0.484157606580319 4.02222513573154e-05 0.443725972486773 2.72881965678652e-14 miRNATAP -0.123267122301907 3.51783238534121e-13 NA NA NA hsa-miR-335-5p CTDP1 -2.61355235628987 2.6462884165886e-51 0.52217173223553 1.43376920627947e-14 miRNAWalker2_validate -0.106891143148032 1.68706562351934e-17 NA NA NA hsa-miR-429 CTDSP2 2.84108892259147 3.88520896426515e-64 -0.729241442292955 1.0301540254669e-37 miRNATAP -0.118418268365058 1.57919394281276e-27 NA NA NA hsa-miR-96-5p CTDSP2 3.24596558166606 1.92296159041707e-98 -0.729241442292955 1.0301540254669e-37 TargetScan -0.120949511617331 2.37994113166961e-26 NA NA NA hsa-miR-183-5p CTDSPL 2.95681814393872 1.09965777344285e-92 -0.590202944121454 1.39580025090321e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.101383701610104 4.89835086596128e-12 NA NA NA hsa-miR-21-3p CTDSPL 2.17476065946878 5.15299442583591e-75 -0.590202944121454 1.39580025090321e-17 MirTarget -0.172657962165768 1.45189310832527e-21 NA NA NA hsa-miR-375 CTGF 2.09893673049766 1.68351780396203e-16 -0.492053877527233 0.000535095367324139 miRNAWalker2_validate;miRanda -0.104861961985773 1.91267729749617e-08 NA NA NA hsa-miR-335-5p CTHRC1 -2.61355235628987 2.6462884165886e-51 2.42953191081835 3.60126977652986e-58 miRNAWalker2_validate -0.287995884753008 1.36354630376811e-22 NA NA NA hsa-miR-429 CTNNAL1 2.84108892259147 3.88520896426515e-64 -1.1834585547448 7.81515701604304e-36 miRanda -0.200194877804016 2.35890663198726e-28 NA NA NA hsa-miR-589-5p CTNNB1 0.367182541239722 1.67804815542873e-05 -0.339832485209634 2.23758599550069e-07 miRNATAP -0.163417588837067 5.37234569206233e-10 NA NA NA hsa-miR-125a-5p CTNNBIP1 -0.635694700253268 3.6703235721638e-11 -0.152746828348167 0.0359779995328641 mirMAP -0.106861426150118 3.21438994353657e-05 NA NA NA hsa-miR-375 CTSC 2.09893673049766 1.68351780396203e-16 -0.18411122557398 0.115978962720345 miRNAWalker2_validate -0.16388007585322 5.42377488857199e-28 NA NA NA hsa-miR-335-5p CTSD -2.61355235628987 2.6462884165886e-51 1.26916265084379 2.33407265311662e-28 miRNAWalker2_validate -0.193645260512742 3.48841403649002e-19 NA NA NA hsa-miR-429 CTSK 2.84108892259147 3.88520896426515e-64 -0.208994534223568 0.153447532390706 miRanda -0.225345697150646 1.28846964337365e-16 NA NA NA hsa-miR-429 CTSO 2.84108892259147 3.88520896426515e-64 -0.596240932123563 1.12805906834711e-14 miRanda -0.157557653799631 5.57007506142446e-28 NA NA NA hsa-miR-141-3p CTTNBP2 2.99777540204168 1.26370498493024e-78 -2.41132364496224 1.70068651679973e-31 miRNATAP -0.48438604285692 1.34201756495466e-33 NA NA NA hsa-miR-200a-3p CTTNBP2 2.55218480823434 2.96135446816238e-51 -2.41132364496224 1.70068651679973e-31 miRNATAP -0.417595545099797 8.02479077177629e-26 NA NA NA hsa-miR-429 CTTNBP2 2.84108892259147 3.88520896426515e-64 -2.41132364496224 1.70068651679973e-31 miRanda -0.414727046482985 8.07578076380654e-26 NA NA NA hsa-miR-139-3p CTU1 -3.44089023199323 1.67292890850702e-91 0.889605072472649 8.82170726857728e-16 MirTarget -0.131242707978072 6.70905834316032e-11 NA NA NA hsa-miR-335-5p CTXN1 -2.61355235628987 2.6462884165886e-51 3.18809751718317 9.37262199827997e-82 miRNAWalker2_validate -0.385899283337123 1.60495449242537e-31 NA NA NA hsa-miR-375 CUBN 2.09893673049766 1.68351780396203e-16 -1.92999004425265 2.52844875363356e-61 miRanda -0.186847775291894 2.21572590504544e-31 NA NA NA hsa-miR-200b-3p CUTC 2.11744072703209 1.66710572104191e-43 -0.853774255373969 9.05123514016953e-44 MirTarget -0.139802015777313 1.2310536389459e-25 NA NA NA hsa-miR-200c-3p CUTC 2.07038651806183 6.84613386286599e-51 -0.853774255373969 9.05123514016953e-44 MirTarget -0.151619219375088 6.14895659894412e-25 NA NA NA hsa-miR-429 CUTC 2.84108892259147 3.88520896426515e-64 -0.853774255373969 9.05123514016953e-44 MirTarget;miRanda -0.122987912236035 6.97139136668074e-25 NA NA NA hsa-miR-429 CUX2 2.84108892259147 3.88520896426515e-64 -1.98415178612038 3.18562792827951e-12 miRNATAP -0.262906657952088 1.3581981240555e-06 NA NA NA hsa-miR-183-5p CX3CL1 2.95681814393872 1.09965777344285e-92 -2.71182430422596 3.50152905238866e-53 MirTarget -0.483837538286354 5.38967835843324e-37 NA NA NA hsa-miR-429 CX3CR1 2.84108892259147 3.88520896426515e-64 -1.66437929012717 7.70224449396999e-18 miRNATAP -0.298695917381086 4.65354086424143e-16 NA NA NA hsa-miR-139-5p CXCL10 -3.25846663863766 2.62018989415003e-112 2.8196032456922 5.8349410793568e-35 miRanda -0.584368197695352 2.43800665919217e-35 NA NA NA hsa-miR-139-5p CXCL11 -3.25846663863766 2.62018989415003e-112 2.86091462678506 9.69555607411884e-32 miRanda -0.574245560288077 4.87309232985364e-30 NA NA NA hsa-miR-141-3p CXCL12 2.99777540204168 1.26370498493024e-78 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.448767864284497 1.69254754152554e-65 NA NA NA hsa-miR-200a-3p CXCL12 2.55218480823434 2.96135446816238e-51 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.360989618953587 4.22159254970216e-42 NA NA NA hsa-miR-375 CXCL12 2.09893673049766 1.68351780396203e-16 -2.12095060237474 3.84001932998671e-54 PITA;miRanda -0.130667047793173 8.04931756867824e-12 NA NA NA hsa-miR-429 CXCL12 2.84108892259147 3.88520896426515e-64 -2.12095060237474 3.84001932998671e-54 miRanda;miRNATAP -0.378344732495558 2.69106217688879e-47 NA NA NA hsa-miR-96-5p CXCL12 3.24596558166606 1.92296159041707e-98 -2.12095060237474 3.84001932998671e-54 mirMAP -0.443550931300625 2.61489112931284e-61 NA NA NA hsa-miR-486-5p CXCL13 -3.87258704301474 1.22658629378451e-80 2.79936288144029 3.49869289267497e-15 miRanda -0.329984248507108 1.43040459665188e-09 NA NA NA hsa-miR-139-5p CXCL17 -3.25846663863766 2.62018989415003e-112 0.572003897634211 0.118641676902029 miRanda -0.16614211342095 0.0278513122825296 NA NA NA hsa-miR-375 CXCL6 2.09893673049766 1.68351780396203e-16 -1.94795420724642 3.10169096356284e-12 miRanda -0.300338474424163 2.80312431457939e-16 NA NA NA hsa-miR-335-5p CXCL9 -2.61355235628987 2.6462884165886e-51 2.07744330424468 1.00574710290073e-14 miRNAWalker2_validate -0.202518313282042 6.28089782484417e-05 NA NA NA hsa-miR-139-5p CXCR4 -3.25846663863766 2.62018989415003e-112 1.13225697348151 3.70953211884683e-22 PITA;miRanda -0.187288113892581 1.46110820392715e-14 NA NA NA hsa-miR-486-5p CXCR4 -3.87258704301474 1.22658629378451e-80 1.13225697348151 3.70953211884683e-22 miRanda -0.120135613461076 2.81650811298874e-11 NA NA NA hsa-miR-486-5p CXCR5 -3.87258704301474 1.22658629378451e-80 1.54332186873333 1.41440227822405e-11 miRanda;miRNATAP -0.106256233314934 0.00249264144446818 NA NA NA hsa-miR-130a-3p CXXC4 -1.15024914519431 6.51290317952496e-19 -0.348454370147505 0.0800945501479367 miRNATAP -0.241623697494787 2.61410952091639e-06 NA NA NA hsa-miR-130b-3p CXXC4 1.38122163823846 1.00932179737836e-26 -0.348454370147505 0.0800945501479367 miRNATAP -0.23463521783126 4.93673028390429e-06 NA NA NA hsa-miR-140-5p CXXC4 -0.755971041589807 9.68060922934542e-14 -0.348454370147505 0.0800945501479367 miRanda -0.132297143749825 0.0468117068070835 NA NA NA hsa-miR-146a-5p CXXC4 0.102405752365098 0.486975378688068 -0.348454370147505 0.0800945501479367 MirTarget -0.177215728802693 0.000129668828770531 NA NA NA hsa-miR-146b-5p CXXC4 0.631041661167954 6.20366593452965e-08 -0.348454370147505 0.0800945501479367 MirTarget;miRNATAP -0.402161602310286 2.78295064213365e-12 NA NA NA hsa-miR-148a-5p CXXC4 0.572692271754695 2.14306251522796e-06 -0.348454370147505 0.0800945501479367 mirMAP -0.113422138971705 0.0441472444914234 NA NA NA hsa-miR-186-5p CXXC4 -0.426987301460247 1.04129380549315e-05 -0.348454370147505 0.0800945501479367 mirMAP -0.185188272588669 0.00861357423571367 NA NA NA hsa-miR-19b-1-5p CXXC4 0.647704962003062 3.07687667945597e-07 -0.348454370147505 0.0800945501479367 MirTarget -0.218495308109611 4.52597594786824e-05 NA NA NA hsa-miR-21-5p CXXC4 2.32007501846389 3.08394781855554e-137 -0.348454370147505 0.0800945501479367 mirMAP -0.257452952558405 3.19200115682289e-05 NA NA NA hsa-miR-223-3p CXXC4 -0.966406159689943 7.90612601654887e-12 -0.348454370147505 0.0800945501479367 MirTarget -0.339412266927715 5.92753918193085e-13 NA NA NA hsa-miR-224-5p CXXC4 -2.22249420723892 1.07787949391113e-18 -0.348454370147505 0.0800945501479367 MirTarget -0.181942353850854 3.60612131804488e-12 NA NA NA hsa-miR-452-5p CXXC4 -2.48486455572568 1.24430987974325e-33 -0.348454370147505 0.0800945501479367 miRNATAP -0.234320108333777 8.18417899337699e-14 NA NA NA hsa-miR-485-3p CXXC4 -0.866822427729628 4.5194665263492e-11 -0.348454370147505 0.0800945501479367 MirTarget -0.129507483208911 0.0125618139631789 NA NA NA hsa-miR-532-5p CXXC4 0.0386976222860582 0.682018574136515 -0.348454370147505 0.0800945501479367 MirTarget;PITA;miRNATAP -0.496712025500665 4.77750045893798e-12 NA NA NA hsa-miR-589-5p CXXC4 0.367182541239722 1.67804815542873e-05 -0.348454370147505 0.0800945501479367 MirTarget;miRNATAP -0.397030086932275 6.52239923121845e-07 NA NA NA hsa-miR-590-3p CXXC4 1.27438512890514 1.03164723481469e-23 -0.348454370147505 0.0800945501479367 mirMAP -0.22340700282172 4.26165162563516e-05 NA NA NA hsa-miR-590-5p CXXC4 0.746515607868274 8.51300479640125e-09 -0.348454370147505 0.0800945501479367 mirMAP -0.220064131956899 2.44213519940944e-05 NA NA NA hsa-miR-660-5p CXXC4 0.406910761707485 0.000156175371762464 -0.348454370147505 0.0800945501479367 miRNATAP -0.558306258370776 2.42822704122193e-19 NA NA NA hsa-miR-708-3p CXXC4 0.478640655706813 2.13865852505288e-05 -0.348454370147505 0.0800945501479367 MirTarget -0.255893073883026 2.2233000962564e-05 NA NA NA hsa-miR-889-3p CXXC4 -0.377352927733213 0.00501260024755438 -0.348454370147505 0.0800945501479367 MirTarget -0.216720712252581 1.93828204405402e-05 NA NA NA hsa-miR-429 CXorf36 2.84108892259147 3.88520896426515e-64 -2.10347807534663 4.27131231688377e-80 miRNATAP -0.364471227866258 1.05853313732676e-64 NA NA NA hsa-miR-10b-5p CYB561 -2.10996264627796 7.36811595736367e-72 1.30368962005439 2.06872779226279e-42 mirMAP -0.254410719008814 2.31000208724176e-22 NA NA NA hsa-miR-335-5p CYB561 -2.61355235628987 2.6462884165886e-51 1.30368962005439 2.06872779226279e-42 miRNAWalker2_validate -0.149097773065066 5.09494908145482e-16 NA NA NA hsa-miR-183-5p CYB5D2 2.95681814393872 1.09965777344285e-92 -0.40923311885213 5.47376292220716e-05 miRNAWalker2_validate -0.113401358392134 1.04201873494124e-07 NA NA NA hsa-miR-429 CYBB 2.84108892259147 3.88520896426515e-64 -0.191421903908804 0.153002670239255 miRanda -0.111531086646935 1.0208810919372e-05 NA NA NA hsa-miR-21-5p CYBRD1 2.32007501846389 3.08394781855554e-137 -1.65279857617782 2.59153209850489e-26 miRNAWalker2_validate -0.527905475921927 1.46100151801666e-27 NA NA NA hsa-miR-429 CYBRD1 2.84108892259147 3.88520896426515e-64 -1.65279857617782 2.59153209850489e-26 miRanda;miRNATAP -0.307914193462445 2.19974221683058e-25 NA NA NA hsa-miR-139-5p CYCS -3.25846663863766 2.62018989415003e-112 0.514544707933127 7.20434543139638e-13 miRanda -0.138771276194956 1.91475094017139e-21 NA NA NA hsa-miR-429 CYGB 2.84108892259147 3.88520896426515e-64 -1.25610360645473 2.459282774763e-24 miRNATAP -0.285257204974323 4.04863069752734e-35 NA NA NA hsa-miR-96-5p CYGB 3.24596558166606 1.92296159041707e-98 -1.25610360645473 2.459282774763e-24 TargetScan;miRNATAP -0.294158341791382 3.05796528302338e-34 NA NA NA hsa-miR-200b-3p CYP1B1 2.11744072703209 1.66710572104191e-43 -0.366349924852417 0.0219371555678365 TargetScan -0.170429488545407 4.45723402410594e-07 NA NA NA hsa-miR-200c-3p CYP1B1 2.07038651806183 6.84613386286599e-51 -0.366349924852417 0.0219371555678365 miRNATAP -0.131482636782662 0.000418466827494499 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response drug resistance kidney renal cell cancer hsa-miR-429 CYP1B1 2.84108892259147 3.88520896426515e-64 -0.366349924852417 0.0219371555678365 miRanda;miRNATAP -0.151479964870075 5.04879870928047e-07 NA NA NA hsa-miR-335-5p CYP26A1 -2.61355235628987 2.6462884165886e-51 0.19977462201463 0.474449646115272 miRNAWalker2_validate -0.163125604751658 0.00164906588914389 NA NA NA hsa-miR-141-3p CYP26B1 2.99777540204168 1.26370498493024e-78 -2.18251820929743 2.06650075366595e-36 MirTarget;TargetScan;miRNATAP -0.468193892142109 8.8877242775259e-45 NA NA NA hsa-miR-200a-3p CYP26B1 2.55218480823434 2.96135446816238e-51 -2.18251820929743 2.06650075366595e-36 MirTarget;miRNATAP -0.395715664654096 1.11650580193469e-32 NA NA NA hsa-miR-429 CYP2U1 2.84108892259147 3.88520896426515e-64 -1.62191580466329 2.83691682258952e-65 miRNATAP -0.263028043711592 5.17737943537065e-46 NA NA NA hsa-miR-429 CYP4B1 2.84108892259147 3.88520896426515e-64 -1.48688001552278 5.31752537699623e-06 miRanda -0.32929739276041 1.01071731885962e-07 NA NA NA hsa-miR-21-5p CYP4V2 2.32007501846389 3.08394781855554e-137 -0.537843507962225 2.14414668595987e-08 miRNAWalker2_validate -0.215885119351738 4.13077530023717e-13 NA NA NA hsa-miR-375 CYP7B1 2.09893673049766 1.68351780396203e-16 -1.30562641941586 1.13663571946736e-17 miRanda -0.18710371144923 1.11648436123317e-20 NA NA NA hsa-miR-429 CYR61 2.84108892259147 3.88520896426515e-64 -1.67425963822887 4.63799641068601e-30 miRanda -0.284265619579479 4.66070827542544e-24 NA NA NA hsa-miR-200b-3p CYTH3 2.11744072703209 1.66710572104191e-43 -0.739339936855419 6.60636378987249e-16 MirTarget;TargetScan -0.179688735229407 1.31004009391563e-20 NA NA NA hsa-miR-200c-3p CYTH3 2.07038651806183 6.84613386286599e-51 -0.739339936855419 6.60636378987249e-16 MirTarget -0.231010764393206 4.28100692899043e-28 NA NA NA hsa-miR-429 CYTH3 2.84108892259147 3.88520896426515e-64 -0.739339936855419 6.60636378987249e-16 MirTarget;miRanda;miRNATAP -0.170796682496421 2.72137450734367e-23 NA NA NA hsa-miR-96-5p CYTH3 3.24596558166606 1.92296159041707e-98 -0.739339936855419 6.60636378987249e-16 mirMAP -0.174752542370683 2.15843371714347e-22 NA NA NA hsa-miR-183-5p CYYR1 2.95681814393872 1.09965777344285e-92 -2.19800749501088 9.15252090014428e-72 MirTarget -0.380866010979716 5.68158186301988e-46 NA NA NA hsa-miR-429 CYYR1 2.84108892259147 3.88520896426515e-64 -2.19800749501088 9.15252090014428e-72 miRanda -0.28796179893134 6.69037124482937e-32 NA NA NA hsa-miR-130b-3p DAAM1 1.38122163823846 1.00932179737836e-26 -0.82527787657938 1.6912841517564e-12 MirTarget;miRNATAP -0.119223163450559 9.89442748145749e-05 NA NA NA hsa-miR-181a-5p DAAM1 0.635863607630183 6.72486918157744e-11 -0.82527787657938 1.6912841517564e-12 mirMAP -0.320622611303431 3.63286030739205e-15 NA NA NA hsa-miR-181b-5p DAAM1 1.22749257795094 1.21998198830919e-27 -0.82527787657938 1.6912841517564e-12 mirMAP -0.297706446427752 3.7202331187859e-18 NA NA NA hsa-miR-181c-5p DAAM1 0.574847839298605 4.51287502066478e-07 -0.82527787657938 1.6912841517564e-12 mirMAP -0.250470942223665 9.24701348872529e-13 NA NA NA hsa-miR-194-5p DAAM1 0.467781870340114 1.0386810618625e-07 -0.82527787657938 1.6912841517564e-12 miRNATAP -0.189174045503208 3.95432785140071e-05 NA NA NA hsa-miR-19a-3p DAAM1 0.817507952171848 3.76285090469625e-08 -0.82527787657938 1.6912841517564e-12 miRNATAP -0.190478397802553 1.17645107395773e-12 NA NA NA hsa-miR-19b-3p DAAM1 0.139124391010031 0.255658553872934 -0.82527787657938 1.6912841517564e-12 miRNATAP -0.169719982996084 2.92738495486855e-07 NA NA NA hsa-miR-21-5p DAAM1 2.32007501846389 3.08394781855554e-137 -0.82527787657938 1.6912841517564e-12 miRNAWalker2_validate -0.280306110680269 1.3190405082497e-14 NA NA NA hsa-miR-27a-3p DAAM1 0.388496361379095 1.42373532086331e-05 -0.82527787657938 1.6912841517564e-12 miRNATAP -0.214645452354381 2.10218326613165e-06 NA NA NA hsa-miR-29a-3p DAAM1 -0.699539666833076 1.13935003139957e-13 -0.82527787657938 1.6912841517564e-12 MirTarget;miRNATAP -0.19764404076712 3.31620000413814e-06 NA NA NA hsa-miR-29b-3p DAAM1 0.438847962603729 6.46722433236121e-05 -0.82527787657938 1.6912841517564e-12 MirTarget;miRNATAP -0.149791302355507 4.83700986797815e-05 NA NA NA hsa-miR-29c-3p DAAM1 -0.0652732378039769 0.563774115756922 -0.82527787657938 1.6912841517564e-12 MirTarget;miRNATAP -0.152602454746229 2.18628177659896e-05 NA NA NA hsa-miR-32-5p DAAM1 1.38676603945192 2.29428299685976e-34 -0.82527787657938 1.6912841517564e-12 miRNATAP -0.184869801891824 6.4290036355108e-08 NA NA NA hsa-miR-320a DAAM1 -0.287921276129346 0.00141693637596294 -0.82527787657938 1.6912841517564e-12 miRanda -0.164568986730623 0.00026548350856992 NA NA NA hsa-miR-500a-3p DAAM1 0.139523673241448 0.185528510741158 -0.82527787657938 1.6912841517564e-12 MirTarget -0.182020512089716 2.32427170809983e-06 NA NA NA hsa-miR-590-3p DAAM1 1.27438512890514 1.03164723481469e-23 -0.82527787657938 1.6912841517564e-12 MirTarget;miRanda;mirMAP -0.118654937699321 0.000263360597662213 NA NA NA hsa-miR-96-5p DAAM1 3.24596558166606 1.92296159041707e-98 -0.82527787657938 1.6912841517564e-12 TargetScan;miRNATAP -0.102839541953941 1.06315967280966e-05 NA NA NA hsa-miR-141-5p DAAM2 2.38411349683216 4.56310582620282e-58 -1.92805635027671 2.37223617810461e-48 mirMAP -0.38681514285257 1.29341814943135e-41 NA NA NA hsa-miR-146b-5p DAAM2 0.631041661167954 6.20366593452965e-08 -1.92805635027671 2.37223617810461e-48 miRanda -0.195815046000345 1.61868128738395e-06 NA NA NA hsa-miR-182-5p DAAM2 2.36408084103818 2.60011457600281e-72 -1.92805635027671 2.37223617810461e-48 mirMAP -0.428502281083267 1.77522555258754e-41 NA NA NA hsa-miR-18a-5p DAAM2 0.969066793715868 1.69069796425892e-08 -1.92805635027671 2.37223617810461e-48 miRNAWalker2_validate -0.128936539387179 3.13505694340858e-06 NA NA NA hsa-miR-193a-3p DAAM2 0.310617999804917 0.00477640270974957 -1.92805635027671 2.37223617810461e-48 miRanda -0.165858100319702 0.000144893895245171 NA NA NA hsa-miR-19b-3p DAAM2 0.139124391010031 0.255658553872934 -1.92805635027671 2.37223617810461e-48 miRNAWalker2_validate -0.131066070980346 0.000861544162814882 NA NA NA hsa-miR-429 DAAM2 2.84108892259147 3.88520896426515e-64 -1.92805635027671 2.37223617810461e-48 miRNATAP -0.337876466411536 9.09263363484589e-41 NA NA NA hsa-miR-590-3p DAAM2 1.27438512890514 1.03164723481469e-23 -1.92805635027671 2.37223617810461e-48 miRanda;mirMAP -0.284734148563496 6.64083726278079e-14 NA NA NA hsa-miR-141-3p DAB1 2.99777540204168 1.26370498493024e-78 -0.432897540232205 0.0630097305913186 TargetScan -0.129815823459169 0.0041406560740659 NA NA NA hsa-miR-96-5p DAB2 3.24596558166606 1.92296159041707e-98 -1.07441706975354 3.51977408409549e-29 MirTarget;TargetScan -0.268148098241347 1.41302138361175e-47 NA NA NA hsa-miR-182-5p DAB2IP 2.36408084103818 2.60011457600281e-72 -1.08812496507643 2.47777577438782e-41 miRNATAP -0.201912768014686 1.10710102731585e-24 NA NA NA hsa-miR-21-3p DAB2IP 2.17476065946878 5.15299442583591e-75 -1.08812496507643 2.47777577438782e-41 MirTarget -0.204914818120389 6.94082964475636e-21 NA NA NA hsa-miR-429 DAB2IP 2.84108892259147 3.88520896426515e-64 -1.08812496507643 2.47777577438782e-41 miRanda;miRNATAP -0.11289189954398 1.2494260922321e-12 NA NA NA hsa-miR-96-5p DAB2IP 3.24596558166606 1.92296159041707e-98 -1.08812496507643 2.47777577438782e-41 TargetScan;miRNATAP -0.176098141965132 2.83747395016047e-27 NA NA NA hsa-miR-429 DACH1 2.84108892259147 3.88520896426515e-64 -0.575017531377085 0.0353402640350419 PITA;miRanda;miRNATAP -0.159128405201203 0.00211305189047122 NA NA NA hsa-miR-452-5p DACH1 -2.48486455572568 1.24430987974325e-33 -0.575017531377085 0.0353402640350419 mirMAP -0.511118870941053 3.69161116107759e-34 NA NA NA hsa-miR-200b-3p DACT1 2.11744072703209 1.66710572104191e-43 0.215644957293964 0.116094250345454 TargetScan -0.171152597035203 3.05124361992579e-09 NA NA NA hsa-miR-200c-3p DACT1 2.07038651806183 6.84613386286599e-51 0.215644957293964 0.116094250345454 miRNATAP -0.214743266019268 1.14926241164992e-11 NA NA NA hsa-miR-429 DACT1 2.84108892259147 3.88520896426515e-64 0.215644957293964 0.116094250345454 PITA;miRanda;miRNATAP -0.132341050358178 3.04965813397477e-07 NA NA NA hsa-miR-429 DACT3 2.84108892259147 3.88520896426515e-64 0.192034866197905 0.106012442289676 miRanda -0.151693604215122 9.04030334549106e-12 NA NA NA hsa-miR-10b-5p DAZAP1 -2.10996264627796 7.36811595736367e-72 0.767931333028503 5.830018497381e-35 MirTarget;miRNATAP -0.246576189125535 2.8896715135104e-52 NA NA NA hsa-miR-486-5p DBF4 -3.87258704301474 1.22658629378451e-80 1.09073704108042 1.41312552290761e-34 miRanda -0.1210357957106 1.87581937119865e-18 NA NA NA hsa-miR-335-5p DBNDD1 -2.61355235628987 2.6462884165886e-51 1.94439713754885 2.64720145512014e-50 mirMAP -0.230985460408112 5.45586422137036e-20 NA NA NA hsa-miR-10b-5p DBNL -2.10996264627796 7.36811595736367e-72 0.450755651730178 1.37211838599423e-13 mirMAP -0.114701715281909 1.64918408030196e-12 NA NA NA hsa-miR-139-5p DCBLD1 -3.25846663863766 2.62018989415003e-112 0.468835473752553 2.89905978427496e-07 miRanda -0.146908505807915 3.11520512512391e-15 NA NA NA hsa-miR-200b-3p DCBLD2 2.11744072703209 1.66710572104191e-43 -0.917133394406548 5.34724051251788e-23 MirTarget;TargetScan -0.162742843767685 2.77976107416141e-16 NA NA NA hsa-miR-200c-3p DCBLD2 2.07038651806183 6.84613386286599e-51 -0.917133394406548 5.34724051251788e-23 MirTarget -0.214264937800917 4.83838631904915e-23 NA NA NA hsa-miR-429 DCBLD2 2.84108892259147 3.88520896426515e-64 -0.917133394406548 5.34724051251788e-23 MirTarget;PITA;miRanda;miRNATAP -0.140180952371631 3.22812122530965e-15 NA NA NA hsa-miR-196a-5p DCDC2 2.33423717464504 3.646557504928e-18 -1.85592640035043 1.11259871848993e-09 MirTarget;miRNATAP -0.119385991242308 0.00186313875107661 NA NA NA hsa-miR-375 DCHS2 2.09893673049766 1.68351780396203e-16 -1.99755662696167 1.4190733423489e-21 miRanda -0.305804488761682 6.03783381030593e-29 NA NA NA hsa-miR-429 DCHS2 2.84108892259147 3.88520896426515e-64 -1.99755662696167 1.4190733423489e-21 miRanda -0.21796830129514 7.08671762466072e-08 NA NA NA hsa-miR-429 DCLK1 2.84108892259147 3.88520896426515e-64 -1.46888367029758 2.60502733473862e-12 miRanda -0.265376834990967 2.84194985692894e-11 NA NA NA hsa-miR-21-3p DCP1A 2.17476065946878 5.15299442583591e-75 -0.727525387038966 1.14961913171134e-35 MirTarget -0.124163516435149 3.42427109463478e-15 NA NA NA hsa-miR-21-5p DCP1A 2.32007501846389 3.08394781855554e-137 -0.727525387038966 1.14961913171134e-35 miRNAWalker2_validate -0.268749269182896 1.65793554093642e-51 NA NA NA hsa-miR-452-5p DCTN4 -2.48486455572568 1.24430987974325e-33 -0.116633510165263 0.0782897889426786 mirMAP -0.118497444081383 2.55654391701999e-31 NA NA NA hsa-miR-141-3p DCUN1D3 2.99777540204168 1.26370498493024e-78 -1.06136698889532 1.78469564912163e-54 MirTarget;TargetScan -0.200266235728814 5.13180996799693e-51 NA NA NA hsa-miR-200a-3p DCUN1D3 2.55218480823434 2.96135446816238e-51 -1.06136698889532 1.78469564912163e-54 MirTarget -0.162885585039659 3.80601915743393e-34 NA NA NA hsa-miR-200b-3p DCUN1D3 2.11744072703209 1.66710572104191e-43 -1.06136698889532 1.78469564912163e-54 TargetScan -0.181182787572894 3.74582101862922e-34 NA NA NA hsa-miR-96-5p DCUN1D3 3.24596558166606 1.92296159041707e-98 -1.06136698889532 1.78469564912163e-54 TargetScan -0.169800714080106 1.53315829418462e-34 NA NA NA hsa-miR-141-3p DCX 2.99777540204168 1.26370498493024e-78 -2.74666176017894 1.23860367619362e-14 TargetScan -0.209405150885142 0.00293185473310962 NA NA NA hsa-miR-182-5p DCX 2.36408084103818 2.60011457600281e-72 -2.74666176017894 1.23860367619362e-14 mirMAP;miRNATAP -0.276627946448891 0.00134048017119506 NA NA NA hsa-miR-183-5p DCX 2.95681814393872 1.09965777344285e-92 -2.74666176017894 1.23860367619362e-14 MirTarget;miRNATAP -0.302550097702794 7.1090449268374e-05 NA NA NA hsa-miR-200a-5p DCX 2.58844508672328 1.79650654234569e-56 -2.74666176017894 1.23860367619362e-14 mirMAP -0.14237529818514 0.0444008641314236 NA NA NA hsa-miR-429 DCX 2.84108892259147 3.88520896426515e-64 -2.74666176017894 1.23860367619362e-14 miRNATAP -0.196144602402914 0.00424949657406483 NA NA NA hsa-miR-96-5p DCX 3.24596558166606 1.92296159041707e-98 -2.74666176017894 1.23860367619362e-14 TargetScan;miRNATAP -0.338576502163831 2.05400089392322e-06 NA NA NA hsa-miR-21-5p DDHD2 2.32007501846389 3.08394781855554e-137 -0.491133834973351 1.44554321609657e-05 miRNAWalker2_validate -0.272751343136749 5.48298837525733e-15 NA NA NA hsa-miR-141-3p DDI2 2.99777540204168 1.26370498493024e-78 -0.874948299770357 1.36141202726123e-06 mirMAP -0.12916978300103 0.000259964174752733 NA NA NA hsa-miR-200a-3p DDI2 2.55218480823434 2.96135446816238e-51 -0.874948299770357 1.36141202726123e-06 mirMAP -0.120570867690186 0.000513750730903842 NA NA NA hsa-miR-96-5p DDI2 3.24596558166606 1.92296159041707e-98 -0.874948299770357 1.36141202726123e-06 TargetScan -0.133323260000709 0.00020997361553145 NA NA NA hsa-miR-200b-3p DDIT4L 2.11744072703209 1.66710572104191e-43 -1.72136204540736 8.31023692335201e-21 MirTarget -0.293176758879881 1.08353405270708e-13 NA NA NA hsa-miR-200c-3p DDIT4L 2.07038651806183 6.84613386286599e-51 -1.72136204540736 8.31023692335201e-21 MirTarget -0.40326983794807 6.35694817505525e-21 NA NA NA hsa-miR-429 DDIT4L 2.84108892259147 3.88520896426515e-64 -1.72136204540736 8.31023692335201e-21 MirTarget;miRanda;miRNATAP -0.263444626684293 7.51227449621259e-14 NA NA NA hsa-miR-335-5p DDN -2.61355235628987 2.6462884165886e-51 1.01850891023718 1.91782984431296e-06 miRNAWalker2_validate -0.212178125388826 9.27715144662583e-08 NA NA NA hsa-miR-335-5p DDR1 -2.61355235628987 2.6462884165886e-51 1.06400195999824 5.66663397427487e-33 miRNAWalker2_validate -0.1423277047421 3.44602164294e-17 NA NA NA hsa-miR-21-5p DDR2 2.32007501846389 3.08394781855554e-137 -2.82230780338797 3.17031317948984e-48 miRNAWalker2_validate -0.617737869765056 4.17421223874419e-23 NA NA NA hsa-miR-139-5p DDX11 -3.25846663863766 2.62018989415003e-112 0.719852991423221 9.78791563479914e-13 miRanda -0.182142877885288 1.04443477911283e-18 NA NA NA hsa-miR-335-5p DDX11 -2.61355235628987 2.6462884165886e-51 0.719852991423221 9.78791563479914e-13 mirMAP -0.124027614956682 4.22051535694448e-11 NA NA NA hsa-miR-21-5p DDX3X 2.32007501846389 3.08394781855554e-137 -0.633836580338372 1.2639702124411e-30 miRNAWalker2_validate -0.202520686411427 2.54629721847157e-32 NA NA NA hsa-miR-375 DDX43 2.09893673049766 1.68351780396203e-16 -1.993053537538 2.04227770475839e-15 miRanda -0.202908183149824 1.269954641273e-09 NA NA NA hsa-miR-429 DDX43 2.84108892259147 3.88520896426515e-64 -1.993053537538 2.04227770475839e-15 miRanda -0.309191901770445 1.11362615949685e-10 NA NA NA hsa-miR-145-5p DDX54 -2.62703571936687 7.64402900188551e-88 0.629454563561322 1.70149353018142e-17 MirTarget -0.172306414523893 4.54928157008099e-24 NA NA NA hsa-miR-139-5p DDX58 -3.25846663863766 2.62018989415003e-112 0.589419325048236 6.43559608702027e-08 miRanda;mirMAP -0.14406133116219 1.23143679350426e-10 NA NA NA hsa-miR-139-5p DECR2 -3.25846663863766 2.62018989415003e-112 0.774274541332749 3.66117359461793e-13 miRanda -0.125637950148557 1.27879616958141e-08 NA NA NA hsa-miR-429 DEFB132 2.84108892259147 3.88520896426515e-64 -4.9618660706359 3.65513174378889e-55 miRanda -0.757983793904766 1.42789498702432e-34 NA NA NA hsa-miR-452-5p DENND1B -2.48486455572568 1.24430987974325e-33 0.345089378027681 0.0444703762548203 mirMAP -0.152305894689517 2.32121803201617e-08 NA NA NA hsa-miR-200b-3p DENND2C 2.11744072703209 1.66710572104191e-43 -1.73921300700411 1.51303781815381e-36 TargetScan -0.265074951195699 8.66219250243038e-19 NA NA NA hsa-miR-96-5p DENND2C 3.24596558166606 1.92296159041707e-98 -1.73921300700411 1.51303781815381e-36 MirTarget;TargetScan -0.334495378997624 2.08216023761565e-34 NA NA NA hsa-miR-429 DENND4C 2.84108892259147 3.88520896426515e-64 -0.814572848804994 2.6129801855899e-23 MirTarget;miRanda;miRNATAP -0.111845111803665 1.18730075002014e-12 NA NA NA hsa-miR-200b-3p DENND5A 2.11744072703209 1.66710572104191e-43 -0.764375256872762 3.88256445865292e-35 MirTarget;TargetScan -0.153299012636592 2.43551549311115e-31 NA NA NA hsa-miR-200c-3p DENND5A 2.07038651806183 6.84613386286599e-51 -0.764375256872762 3.88256445865292e-35 MirTarget -0.181507369639065 1.55183408062696e-36 NA NA NA hsa-miR-429 DENND5A 2.84108892259147 3.88520896426515e-64 -0.764375256872762 3.88256445865292e-35 MirTarget;miRanda;miRNATAP -0.144695937968964 3.76704606065266e-35 NA NA NA hsa-miR-182-5p DENND5B 2.36408084103818 2.60011457600281e-72 -1.14155413410849 4.38267204750606e-22 MirTarget;miRNATAP -0.152678446469304 1.06678980995351e-07 NA NA NA hsa-miR-200b-3p DENND5B 2.11744072703209 1.66710572104191e-43 -1.14155413410849 4.38267204750606e-22 MirTarget;TargetScan;mirMAP -0.214271306079196 2.10933160432161e-17 NA NA NA hsa-miR-200c-3p DENND5B 2.07038651806183 6.84613386286599e-51 -1.14155413410849 4.38267204750606e-22 MirTarget;miRNATAP -0.264064948748841 1.10818038269175e-21 NA NA NA hsa-miR-429 DENND5B 2.84108892259147 3.88520896426515e-64 -1.14155413410849 4.38267204750606e-22 MirTarget;miRanda;mirMAP;miRNATAP -0.205564046747208 5.7065087865959e-20 NA NA NA hsa-miR-96-5p DENND5B 3.24596558166606 1.92296159041707e-98 -1.14155413410849 4.38267204750606e-22 miRNATAP -0.196403471020724 7.39647207087238e-17 NA NA NA hsa-miR-139-5p DENR -3.25846663863766 2.62018989415003e-112 0.374461007899709 4.62095418610492e-13 miRanda;miRNATAP -0.105142184208814 1.13360775356549e-23 NA NA NA hsa-miR-139-5p DEPDC1 -3.25846663863766 2.62018989415003e-112 3.17619929587639 1.24465584313586e-64 miRanda -0.639784195648993 2.81646253382224e-61 NA NA NA hsa-miR-139-5p DEPDC7 -3.25846663863766 2.62018989415003e-112 0.944851547165965 1.4550069988056e-10 miRanda -0.303625268481511 2.53456877050283e-24 NA NA NA hsa-miR-486-5p DEPDC7 -3.87258704301474 1.22658629378451e-80 0.944851547165965 1.4550069988056e-10 miRanda -0.150273368027941 1.95807236749613e-11 NA NA NA hsa-miR-139-5p DERL1 -3.25846663863766 2.62018989415003e-112 0.373009225396749 3.88427360060301e-08 miRanda -0.105898827749777 2.07693821934802e-14 NA NA NA hsa-miR-378a-5p DERL3 -2.43173551693523 1.44932837789175e-68 1.13325735405579 4.84930415183079e-11 mirMAP -0.100298081577613 0.0111203526702623 NA NA NA hsa-miR-375 DFNA5 2.09893673049766 1.68351780396203e-16 -0.936402345459662 1.93043899322683e-26 miRanda -0.113991292011124 1.58329601826641e-22 NA NA NA hsa-miR-429 DGAT2 2.84108892259147 3.88520896426515e-64 -3.01170652358299 7.38205972833696e-49 miRanda -0.298253907211135 2.49580779002015e-13 NA NA NA hsa-miR-200b-3p DGKH 2.11744072703209 1.66710572104191e-43 -0.547048774392132 6.50624877314515e-05 TargetScan -0.103304616156979 0.000389266335387264 NA NA NA hsa-miR-10b-5p DGKQ -2.10996264627796 7.36811595736367e-72 0.795482860583099 6.290554049157e-21 mirMAP -0.144385444359328 2.9848136821736e-10 NA NA NA hsa-miR-99a-5p DHCR24 -2.25079447371102 1.14086813185885e-54 0.768977925816538 2.20099811362362e-09 miRNAWalker2_validate -0.136397664142164 1.87903484320646e-06 NA NA NA hsa-miR-335-5p DHCR7 -2.61355235628987 2.6462884165886e-51 1.04668671432409 1.20838057234267e-17 miRNAWalker2_validate -0.167121751128682 2.89044860339116e-13 NA NA NA hsa-miR-429 DHH 2.84108892259147 3.88520896426515e-64 -0.598813747709849 0.000914271045323687 miRNATAP -0.22119033762441 7.21648714505761e-11 NA NA NA hsa-miR-452-5p DHX40 -2.48486455572568 1.24430987974325e-33 -0.0461660313788235 0.575518154014288 MirTarget -0.105700081834879 2.88499446259358e-16 NA NA NA hsa-miR-182-5p DIAPH2 2.36408084103818 2.60011457600281e-72 -1.20202712880697 5.09928447049557e-26 miRNATAP -0.330787042582492 7.66221899062503e-35 NA NA NA hsa-miR-200b-3p DIAPH2 2.11744072703209 1.66710572104191e-43 -1.20202712880697 5.09928447049557e-26 mirMAP -0.258157766848499 1.27409512267861e-26 NA NA NA hsa-miR-200c-3p DIAPH2 2.07038651806183 6.84613386286599e-51 -1.20202712880697 5.09928447049557e-26 mirMAP -0.227851956411517 2.52808083431139e-17 NA NA NA hsa-miR-429 DIAPH2 2.84108892259147 3.88520896426515e-64 -1.20202712880697 5.09928447049557e-26 mirMAP -0.201108518281051 2.485912797576e-20 NA NA NA hsa-miR-96-5p DIAPH2 3.24596558166606 1.92296159041707e-98 -1.20202712880697 5.09928447049557e-26 miRNATAP -0.248017327751483 2.69600094961879e-28 NA NA NA hsa-miR-224-5p DIO1 -2.22249420723892 1.07787949391113e-18 1.90167553117122 1.13404365533563e-07 miRTarBase -0.352294553302583 1.05750240342598e-13 NA NA NA hsa-miR-335-5p DIO1 -2.61355235628987 2.6462884165886e-51 1.90167553117122 1.13404365533563e-07 miRNAWalker2_validate -0.164740505177389 0.0141747010244566 NA NA NA hsa-miR-429 DIO3 2.84108892259147 3.88520896426515e-64 -1.4625311443251 3.73408075983056e-09 miRNATAP -0.346504569797155 1.3075261992137e-13 NA NA NA hsa-miR-429 DIP2C 2.84108892259147 3.88520896426515e-64 -0.756063831514047 1.89367152125463e-25 miRNATAP -0.125014369593498 1.70893962146272e-19 NA NA NA hsa-miR-335-5p DIRAS1 -2.61355235628987 2.6462884165886e-51 0.543959405958899 0.0044823497517942 miRNAWalker2_validate -0.12687551311883 0.000360371354837535 NA NA NA hsa-miR-200b-3p DIRAS2 2.11744072703209 1.66710572104191e-43 -2.10620497339661 3.78327238934435e-17 TargetScan -0.123216826999439 0.0229710931633841 NA NA NA hsa-miR-429 DIRAS2 2.84108892259147 3.88520896426515e-64 -2.10620497339661 3.78327238934435e-17 miRanda -0.191861293465708 6.96160704841231e-05 NA NA NA hsa-miR-429 DISC1 2.84108892259147 3.88520896426515e-64 -0.749733013619098 1.56009977071317e-15 miRNATAP -0.143839902520294 6.8457481090998e-16 NA NA NA hsa-miR-141-5p DIXDC1 2.38411349683216 4.56310582620282e-58 -1.64219180882631 5.60950919042518e-55 mirMAP -0.24887260011409 2.83813912411844e-26 NA NA NA hsa-miR-200b-3p DIXDC1 2.11744072703209 1.66710572104191e-43 -1.64219180882631 5.60950919042518e-55 MirTarget;TargetScan -0.225258063725434 4.24903178671413e-22 NA NA NA hsa-miR-200c-3p DIXDC1 2.07038651806183 6.84613386286599e-51 -1.64219180882631 5.60950919042518e-55 MirTarget -0.322709555114611 8.03840245468509e-38 NA NA NA hsa-miR-429 DIXDC1 2.84108892259147 3.88520896426515e-64 -1.64219180882631 5.60950919042518e-55 MirTarget;PITA;miRanda;miRNATAP -0.242701302051786 3.12958876033888e-32 NA NA NA hsa-miR-96-5p DIXDC1 3.24596558166606 1.92296159041707e-98 -1.64219180882631 5.60950919042518e-55 MirTarget -0.261369986717537 2.20536017330862e-34 NA NA NA hsa-miR-146b-5p DKK2 0.631041661167954 6.20366593452965e-08 -0.742804900441963 3.00060009120271e-06 miRanda -0.214456904219556 4.16641532867677e-06 NA NA NA hsa-miR-193a-3p DKK2 0.310617999804917 0.00477640270974957 -0.742804900441963 3.00060009120271e-06 miRanda -0.19209434845159 0.000113861738873523 NA NA NA hsa-miR-221-3p DKK2 -0.317970198201501 0.00910855267413448 -0.742804900441963 3.00060009120271e-06 miRNAWalker2_validate;miRTarBase -0.155357098507464 0.000547828614406337 NA NA NA hsa-miR-27a-3p DKK2 0.388496361379095 1.42373532086331e-05 -0.742804900441963 3.00060009120271e-06 miRNATAP -0.243059240523354 7.10890941131857e-05 NA NA NA hsa-miR-324-5p DKK2 0.211552647440779 0.139408130311654 -0.742804900441963 3.00060009120271e-06 miRanda -0.271141605871372 7.87002052167256e-13 NA NA NA hsa-miR-361-5p DKK2 -0.0996867547900457 0.095428250126326 -0.742804900441963 3.00060009120271e-06 miRanda -0.184249963165667 0.048511583389329 NA NA NA hsa-miR-455-5p DKK2 0.284641224662773 0.0357572339594277 -0.742804900441963 3.00060009120271e-06 miRanda -0.333577119442953 4.85160924554831e-17 NA NA NA hsa-miR-576-5p DKK2 0.0649387707567879 0.588791966096287 -0.742804900441963 3.00060009120271e-06 mirMAP -0.200655010439433 1.08911792496519e-05 NA NA NA hsa-miR-590-3p DKK2 1.27438512890514 1.03164723481469e-23 -0.742804900441963 3.00060009120271e-06 miRanda;mirMAP;miRNATAP -0.294555133043718 1.22206770465475e-11 NA NA NA hsa-miR-590-5p DKK2 0.746515607868274 8.51300479640125e-09 -0.742804900441963 3.00060009120271e-06 miRanda -0.339389607211526 1.97063715460462e-16 NA NA NA hsa-miR-429 DKK3 2.84108892259147 3.88520896426515e-64 -1.28797753555538 2.28706240569895e-25 miRanda -0.230976121349317 1.04012210345162e-22 NA NA NA hsa-miR-141-3p DLC1 2.99777540204168 1.26370498493024e-78 -1.8530731128301 3.51319109988247e-52 TargetScan;miRNATAP -0.432741868485591 1.2910764674069e-79 26278151 MicroRNA 141 regulates the tumour suppressor DLC1 in colorectal cancer; Luciferase reporter assays and Western blots showed that DLC1 was a direct target of miR-141 in CRC; The expression levels of miR-141 were obviously up-regulated in CRC tissues compared to non-cancerous tissues while DLC1 expression levels were down-regulated in a high proportion of clinical samples 14/18; In addition correlation analyses revealed negative correlation between miR-141 levels and DLC1 expression levels in CRC tissues; In conclusion we demonstrated that miR-141 is up-regulated in CRC and acts as a functional oncogene by targeting DLC1 colorectal cancer hsa-miR-200a-3p DLC1 2.55218480823434 2.96135446816238e-51 -1.8530731128301 3.51319109988247e-52 miRNATAP -0.334475150411796 3.98164233713817e-46 NA NA NA hsa-miR-200a-5p DLC1 2.58844508672328 1.79650654234569e-56 -1.8530731128301 3.51319109988247e-52 miRNATAP -0.305604008719118 3.63459470942755e-36 NA NA NA hsa-miR-200b-3p DLC1 2.11744072703209 1.66710572104191e-43 -1.8530731128301 3.51319109988247e-52 TargetScan -0.353191572353844 3.03754552853308e-41 NA NA NA hsa-miR-200c-3p DLC1 2.07038651806183 6.84613386286599e-51 -1.8530731128301 3.51319109988247e-52 miRNATAP -0.447999246169696 2.11821437588801e-56 NA NA NA hsa-miR-429 DLC1 2.84108892259147 3.88520896426515e-64 -1.8530731128301 3.51319109988247e-52 PITA;miRanda;miRNATAP -0.346592931285953 1.27296696673761e-50 NA NA NA hsa-miR-21-5p DLG1 2.32007501846389 3.08394781855554e-137 -0.261835084228021 4.03142509663786e-05 miRNAWalker2_validate -0.145096003426752 1.51465636451203e-13 NA NA NA hsa-miR-182-5p DLG2 2.36408084103818 2.60011457600281e-72 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.264449158994355 1.34413405114361e-11 NA NA NA hsa-miR-429 DLG2 2.84108892259147 3.88520896426515e-64 -1.70773493423543 2.1905000054968e-26 miRNATAP -0.313645248003662 9.70104576239354e-25 NA NA NA hsa-miR-145-5p DLG3 -2.62703571936687 7.64402900188551e-88 1.21494513802964 2.93461327640254e-55 mirMAP -0.237061088767399 8.12285382637334e-38 NA NA NA hsa-miR-335-5p DLG3 -2.61355235628987 2.6462884165886e-51 1.21494513802964 2.93461327640254e-55 miRNAWalker2_validate -0.120030699315025 2.78819500949539e-15 NA NA NA hsa-miR-21-5p DLGAP1 2.32007501846389 3.08394781855554e-137 -1.02472413188979 0.000525250008731226 miRNATAP -0.283778868277711 0.00211859077742049 NA NA NA hsa-miR-200a-5p DLK2 2.58844508672328 1.79650654234569e-56 -2.84286536470749 4.09194328465455e-32 MirTarget -0.246500853799883 4.21966865733597e-07 NA NA NA hsa-miR-429 DLL1 2.84108892259147 3.88520896426515e-64 -0.947678753705407 5.16495496029924e-14 miRanda;miRNATAP -0.182662100183125 1.92659956612559e-14 NA NA NA hsa-miR-429 DLL4 2.84108892259147 3.88520896426515e-64 -0.83958947779597 6.14246425539786e-19 miRanda -0.196094248443088 1.3297685492701e-28 NA NA NA hsa-miR-139-5p DLX3 -3.25846663863766 2.62018989415003e-112 1.14664803709867 5.24437936601366e-07 miRanda -0.2106078848424 8.11787542910295e-06 NA NA NA hsa-miR-139-5p DLX5 -3.25846663863766 2.62018989415003e-112 1.33251796724447 1.74905041149095e-11 miRanda -0.262044526001907 1.48642622168008e-10 NA NA NA hsa-miR-335-5p DLX5 -2.61355235628987 2.6462884165886e-51 1.33251796724447 1.74905041149095e-11 miRNAWalker2_validate -0.272290536558086 1.29167034983344e-13 NA NA NA hsa-miR-335-5p DMBX1 -2.61355235628987 2.6462884165886e-51 2.38292544681912 3.61537747424135e-22 miRNAWalker2_validate -0.225051205303412 1.48417572920186e-06 NA NA NA hsa-miR-200b-3p DMD 2.11744072703209 1.66710572104191e-43 -3.78348112804436 3.23742415858975e-92 TargetScan -0.510427905772079 3.88526815872611e-33 NA NA NA hsa-miR-200c-3p DMD 2.07038651806183 6.84613386286599e-51 -3.78348112804436 3.23742415858975e-92 miRNATAP -0.594316988497947 2.4582438776106e-37 NA NA NA hsa-miR-21-5p DMD 2.32007501846389 3.08394781855554e-137 -3.78348112804436 3.23742415858975e-92 miRNAWalker2_validate -0.924101135044462 8.87022727088876e-52 NA NA NA hsa-miR-375 DMD 2.09893673049766 1.68351780396203e-16 -3.78348112804436 3.23742415858975e-92 miRanda -0.342983601522973 5.56133585632587e-39 NA NA NA hsa-miR-429 DMD 2.84108892259147 3.88520896426515e-64 -3.78348112804436 3.23742415858975e-92 miRanda;miRNATAP -0.493950274361495 3.27123381882023e-39 NA NA NA hsa-miR-200b-3p DMRT2 2.11744072703209 1.66710572104191e-43 -3.08901844202474 2.98127356930882e-47 TargetScan -0.420966708091852 4.44598672992894e-19 NA NA NA hsa-miR-200c-3p DMRT2 2.07038651806183 6.84613386286599e-51 -3.08901844202474 2.98127356930882e-47 miRNATAP -0.571609657439647 5.99062402490001e-29 NA NA NA hsa-miR-375 DMRT2 2.09893673049766 1.68351780396203e-16 -3.08901844202474 2.98127356930882e-47 miRanda -0.205073995406999 4.25814207834915e-12 NA NA NA hsa-miR-429 DMRT2 2.84108892259147 3.88520896426515e-64 -3.08901844202474 2.98127356930882e-47 PITA;miRanda;miRNATAP -0.471286541900305 7.37723785433285e-30 NA NA NA hsa-miR-182-5p DMRT3 2.36408084103818 2.60011457600281e-72 -1.48189589187186 4.02281033296515e-22 miRNATAP -0.333278743299572 1.02971977993275e-19 NA NA NA hsa-miR-375 DMRT3 2.09893673049766 1.68351780396203e-16 -1.48189589187186 4.02281033296515e-22 miRanda -0.154066966138639 5.01971503200999e-14 NA NA NA hsa-miR-96-5p DMRT3 3.24596558166606 1.92296159041707e-98 -1.48189589187186 4.02281033296515e-22 TargetScan;miRNATAP -0.253450205083189 1.09501056168789e-16 NA NA NA hsa-miR-429 DMRTA1 2.84108892259147 3.88520896426515e-64 -2.19856520112596 3.50877220559873e-17 miRanda -0.307961996765811 7.16155504918903e-10 NA NA NA hsa-miR-21-5p DMTF1 2.32007501846389 3.08394781855554e-137 -0.217482261849931 0.000321097008806189 miRNAWalker2_validate -0.11873640097588 2.02827189662546e-10 NA NA NA hsa-miR-141-3p DMXL1 2.99777540204168 1.26370498493024e-78 -0.887801034869518 5.15580975471564e-22 TargetScan;miRNATAP -0.128764608054307 1.21907781714685e-12 NA NA NA hsa-miR-200a-3p DMXL1 2.55218480823434 2.96135446816238e-51 -0.887801034869518 5.15580975471564e-22 miRNATAP -0.116891641367755 5.44879226015795e-11 NA NA NA hsa-miR-429 DMXL1 2.84108892259147 3.88520896426515e-64 -0.887801034869518 5.15580975471564e-22 miRanda -0.145447341308002 1.25432604490307e-16 NA NA NA hsa-miR-96-5p DMXL1 3.24596558166606 1.92296159041707e-98 -0.887801034869518 5.15580975471564e-22 TargetScan;miRNATAP -0.112685261793671 1.14586163840306e-09 NA NA NA hsa-miR-375 DNAH11 2.09893673049766 1.68351780396203e-16 0.627140088965485 0.0385671916153891 miRNAWalker2_validate -0.12247678632858 0.0021945081997406 NA NA NA hsa-miR-486-5p DNAH14 -3.87258704301474 1.22658629378451e-80 1.80033769565743 2.95550762800763e-63 miRanda -0.248469634970432 7.78342399909453e-51 NA NA NA hsa-miR-335-5p DNAH3 -2.61355235628987 2.6462884165886e-51 0.332744337992025 0.209502737233074 miRNAWalker2_validate -0.122816881955466 0.0126861046098025 NA NA NA hsa-miR-99a-5p DNAJA3 -2.25079447371102 1.14086813185885e-54 0.796534002367844 4.74929021985797e-40 miRNAWalker2_validate -0.195670667666161 3.35500740952596e-50 NA NA NA hsa-miR-145-5p DNAJB11 -2.62703571936687 7.64402900188551e-88 0.846821507539959 1.07498028457879e-32 miRNATAP -0.135628478361593 9.80935096514868e-16 NA NA NA hsa-miR-429 DNAJB4 2.84108892259147 3.88520896426515e-64 -1.63447183530182 3.73559018921358e-67 miRanda -0.245538143770079 4.51742087249963e-40 NA NA NA hsa-miR-200b-3p DNAJB5 2.11744072703209 1.66710572104191e-43 -0.230804626842819 0.00593901558381227 TargetScan -0.16209690885105 1.16618877334719e-20 NA NA NA hsa-miR-200c-3p DNAJB5 2.07038651806183 6.84613386286599e-51 -0.230804626842819 0.00593901558381227 miRNATAP -0.223752498175136 1.42531019142238e-32 NA NA NA hsa-miR-429 DNAJB5 2.84108892259147 3.88520896426515e-64 -0.230804626842819 0.00593901558381227 PITA;miRanda;miRNATAP -0.116879892303541 8.84476122423158e-14 NA NA NA hsa-miR-486-5p DNAJC12 -3.87258704301474 1.22658629378451e-80 1.43850602777815 2.34358351695651e-08 miRanda -0.177966429696798 6.01894150053086e-06 NA NA NA hsa-miR-378a-5p DNAJC14 -2.43173551693523 1.44932837789175e-68 0.365440558120891 9.89047618521022e-15 miRNAWalker2_validate -0.137716887431902 8.87798504777904e-41 NA NA NA hsa-miR-200b-3p DNAJC18 2.11744072703209 1.66710572104191e-43 -1.21097498295448 1.75696643911026e-57 TargetScan -0.168564361181547 1.09723433937693e-23 NA NA NA hsa-miR-429 DNAJC18 2.84108892259147 3.88520896426515e-64 -1.21097498295448 1.75696643911026e-57 miRNATAP -0.174239503703309 8.0848136732383e-32 NA NA NA hsa-miR-139-5p DNAJC2 -3.25846663863766 2.62018989415003e-112 0.578629611846193 6.70074833114113e-23 miRanda -0.137955125247662 7.99966476691704e-31 NA NA NA hsa-miR-486-5p DNAJC9 -3.87258704301474 1.22658629378451e-80 0.917756588946022 6.36862407766807e-40 miRanda -0.101797768536776 4.48399557251531e-21 NA NA NA hsa-miR-335-5p DNLZ -2.61355235628987 2.6462884165886e-51 0.94120128017807 2.05828149914456e-13 mirMAP -0.156419192853229 6.09861839032959e-11 NA NA NA hsa-miR-200b-3p DNM3 2.11744072703209 1.66710572104191e-43 -0.810737959701514 9.66102375905489e-13 mirMAP -0.205135096397742 1.14692669079158e-17 NA NA NA hsa-miR-224-5p DNMBP -2.22249420723892 1.07787949391113e-18 -0.666936518001947 1.27257555078449e-08 MirTarget -0.125485470035184 4.67208389056604e-16 NA NA NA hsa-miR-139-5p DNMT3A -3.25846663863766 2.62018989415003e-112 0.954713787765479 1.01650948201553e-39 miRanda -0.209471573757742 1.49761733933282e-45 NA NA NA hsa-miR-486-5p DNMT3A -3.87258704301474 1.22658629378451e-80 0.954713787765479 1.01650948201553e-39 PITA;miRanda -0.108266476492252 6.76162134887432e-22 NA NA NA hsa-miR-145-5p DNMT3B -2.62703571936687 7.64402900188551e-88 1.26852514332715 7.89943263342799e-23 MirTarget -0.231984216994308 2.04108386654072e-14 24071015;25749421 In univariate analysis the combination of DNMT3B overexpression and miR-145 or miR-143 down-regulation was more powerful in predicting shorter survival P < .05 than use of the biomarkers individually P > .05; DNMT3B might be a potential target of miR-145 and miR-143 in ECs; Furthermore the combined miR-145 or miR-143 and DNMT3B status may have a prognostic impact on ECs;It was found that miR-145 upregulates while DNMT3b downregulates in PC3 cells; Responses of the miR-145 and DNMT3b to irradiation are a negative correlation; We also found that either overexpression of miR-145 or knockdown of DNMT3b sensitized prostate cancer cells to X-ray radiation poor survival;drug resistance endometrial cancer;prostate cancer hsa-miR-335-5p DNMT3B -2.61355235628987 2.6462884165886e-51 1.26852514332715 7.89943263342799e-23 miRNAWalker2_validate -0.124254209823111 3.90903882276234e-07 NA NA NA hsa-miR-486-5p DNMT3B -3.87258704301474 1.22658629378451e-80 1.26852514332715 7.89943263342799e-23 miRanda -0.158041670302156 1.47371357708368e-15 NA NA NA hsa-miR-183-5p DOCK1 2.95681814393872 1.09965777344285e-92 -0.831186832284176 2.7914447038444e-24 miRNAWalker2_validate -0.146369813223465 4.00756514610412e-17 NA NA NA hsa-miR-96-5p DOCK1 3.24596558166606 1.92296159041707e-98 -0.831186832284176 2.7914447038444e-24 MirTarget;TargetScan;miRNATAP -0.138971640579189 1.62040499651726e-17 NA NA NA hsa-miR-141-3p DOCK4 2.99777540204168 1.26370498493024e-78 -0.955337759049208 3.43382447572213e-22 MirTarget;TargetScan -0.210393690177201 2.03501174940062e-28 NA NA NA hsa-miR-200a-3p DOCK4 2.55218480823434 2.96135446816238e-51 -0.955337759049208 3.43382447572213e-22 MirTarget -0.185565911049899 5.70205349342196e-23 NA NA NA hsa-miR-200b-3p DOCK4 2.11744072703209 1.66710572104191e-43 -0.955337759049208 3.43382447572213e-22 MirTarget;TargetScan -0.206492508003537 5.41609370323406e-23 NA NA NA hsa-miR-200c-3p DOCK4 2.07038651806183 6.84613386286599e-51 -0.955337759049208 3.43382447572213e-22 MirTarget -0.238022407072748 3.03078217292148e-25 NA NA NA hsa-miR-21-5p DOCK4 2.32007501846389 3.08394781855554e-137 -0.955337759049208 3.43382447572213e-22 miRNAWalker2_validate;miRTarBase -0.217125422672835 3.28471037417372e-12 NA NA NA hsa-miR-429 DOCK4 2.84108892259147 3.88520896426515e-64 -0.955337759049208 3.43382447572213e-22 MirTarget;PITA;miRanda;miRNATAP -0.194168799425531 1.78300496202568e-25 NA NA NA hsa-miR-96-5p DOCK4 3.24596558166606 1.92296159041707e-98 -0.955337759049208 3.43382447572213e-22 TargetScan -0.18084050524918 2.36182122053755e-20 NA NA NA hsa-miR-21-5p DOCK7 2.32007501846389 3.08394781855554e-137 -0.589797954349144 1.57377532548304e-11 miRNAWalker2_validate;miRTarBase -0.216996296670502 1.28480631069162e-15 NA NA NA hsa-miR-96-5p DOCK9 3.24596558166606 1.92296159041707e-98 -0.910412772343475 6.4300753072043e-24 TargetScan;miRNATAP -0.115646343929162 2.00461709053823e-10 NA NA NA hsa-miR-429 DOK5 2.84108892259147 3.88520896426515e-64 -1.15576931944486 1.91344768927017e-15 miRanda;miRNATAP -0.169231729990724 1.14176573067253e-09 NA NA NA hsa-miR-182-5p DPF3 2.36408084103818 2.60011457600281e-72 -1.47580940607343 3.30113268637918e-16 mirMAP -0.398006751737324 1.76241928176221e-20 NA NA NA hsa-miR-429 DPF3 2.84108892259147 3.88520896426515e-64 -1.47580940607343 3.30113268637918e-16 miRNATAP -0.160039278664362 4.14653317793122e-06 NA NA NA hsa-miR-429 DPP4 2.84108892259147 3.88520896426515e-64 -1.94095475576293 9.23340281532771e-27 miRNATAP -0.416837642782193 1.71751712699809e-34 NA NA NA hsa-miR-429 DPP8 2.84108892259147 3.88520896426515e-64 -0.803190899979856 1.50162748810376e-11 miRanda -0.138730300698913 8.67534090732332e-10 NA NA NA hsa-miR-429 DPT 2.84108892259147 3.88520896426515e-64 -3.40162217589106 2.15903385902036e-56 miRNATAP -0.615426877803106 9.72293964728466e-51 NA NA NA hsa-miR-200b-3p DPY19L1 2.11744072703209 1.66710572104191e-43 -0.178318855946124 0.0539793445603746 TargetScan -0.139480581335356 5.89595660847506e-13 NA NA NA hsa-miR-200c-3p DPY19L1 2.07038651806183 6.84613386286599e-51 -0.178318855946124 0.0539793445603746 miRNATAP -0.151975228498484 9.68558203611305e-13 NA NA NA hsa-miR-429 DPY19L1 2.84108892259147 3.88520896426515e-64 -0.178318855946124 0.0539793445603746 miRanda;miRNATAP -0.101831694092798 4.66605074050317e-09 NA NA NA hsa-miR-452-5p DPY19L3 -2.48486455572568 1.24430987974325e-33 -0.0882358035386357 0.476872140641766 mirMAP -0.117439046099718 2.24379131512582e-09 NA NA NA hsa-miR-139-5p DPY30 -3.25846663863766 2.62018989415003e-112 0.853226405502004 2.81859666839538e-39 MirTarget;miRanda;miRNATAP -0.190197765416706 1.17859064784524e-46 NA NA NA hsa-miR-96-5p DPYD 3.24596558166606 1.92296159041707e-98 -1.53162535189484 6.19309067895965e-38 MirTarget -0.344188494654409 7.15962030298979e-50 NA NA NA hsa-miR-141-5p DPYSL2 2.38411349683216 4.56310582620282e-58 -1.55582360892426 1.0041511217522e-60 miRNATAP -0.262541391589992 7.74536857051143e-36 NA NA NA hsa-miR-375 DPYSL2 2.09893673049766 1.68351780396203e-16 -1.55582360892426 1.0041511217522e-60 PITA;miRanda -0.135491498191147 3.96327133933738e-25 NA NA NA hsa-miR-429 DPYSL2 2.84108892259147 3.88520896426515e-64 -1.55582360892426 1.0041511217522e-60 miRNATAP -0.226126892121259 4.11873473499671e-34 NA NA NA hsa-miR-141-3p DPYSL3 2.99777540204168 1.26370498493024e-78 -0.677451473132496 4.89051442199237e-08 TargetScan -0.288398873329492 3.88589665477977e-35 NA NA NA hsa-miR-141-5p DPYSL3 2.38411349683216 4.56310582620282e-58 -0.677451473132496 4.89051442199237e-08 MirTarget -0.258593507351834 5.17646165832613e-23 NA NA NA hsa-miR-375 DPYSL3 2.09893673049766 1.68351780396203e-16 -0.677451473132496 4.89051442199237e-08 miRNAWalker2_validate -0.142654753862139 1.11387734445944e-18 NA NA NA hsa-miR-139-5p DPYSL5 -3.25846663863766 2.62018989415003e-112 0.525859468902229 0.124047624875665 MirTarget;miRanda;miRNATAP -0.232042057918248 0.000969852102855962 NA NA NA hsa-miR-335-5p DPYSL5 -2.61355235628987 2.6462884165886e-51 0.525859468902229 0.124047624875665 miRNAWalker2_validate -0.138562712900215 0.0293235147193194 NA NA NA hsa-miR-141-3p DRD2 2.99777540204168 1.26370498493024e-78 -2.9692348889129 3.17984771024914e-29 TargetScan -0.297197318551456 1.99671159115873e-08 NA NA NA hsa-miR-335-5p DRP2 -2.61355235628987 2.6462884165886e-51 2.1112314420505 1.77413874847491e-40 mirMAP -0.189637468713408 6.52583442791479e-10 NA NA NA hsa-miR-337-3p DSCC1 -2.14274617598363 2.70942896809734e-43 1.08342137817522 4.30341304707371e-18 MirTarget -0.208032685958031 2.31585045744106e-15 NA NA NA hsa-miR-141-5p DSE 2.38411349683216 4.56310582620282e-58 -0.786638070396597 2.93688190144245e-20 MirTarget -0.227062452126025 9.82399272789864e-37 NA NA NA hsa-miR-21-5p DSE 2.32007501846389 3.08394781855554e-137 -0.786638070396597 2.93688190144245e-20 miRNAWalker2_validate -0.108893762885939 6.02880633523486e-05 NA NA NA hsa-miR-141-3p DSEL 2.99777540204168 1.26370498493024e-78 -1.63646239446313 1.15495842561897e-29 TargetScan -0.366759130124937 8.96976078448598e-40 NA NA NA hsa-miR-429 DSEL 2.84108892259147 3.88520896426515e-64 -1.63646239446313 1.15495842561897e-29 miRNATAP -0.343020784782298 1.77616218208272e-36 NA NA NA hsa-miR-21-3p DSG1 2.17476065946878 5.15299442583591e-75 -4.29487961870099 2.77049257859318e-30 MirTarget -0.676403097001064 2.73129599000355e-11 NA NA NA hsa-miR-139-5p DSN1 -3.25846663863766 2.62018989415003e-112 0.990756645464919 2.18409856498358e-34 miRanda -0.213876893170736 5.82615473574319e-38 NA NA NA hsa-miR-141-3p DST 2.99777540204168 1.26370498493024e-78 -2.65768728199613 1.49859497194328e-82 mirMAP -0.3846762141789 4.60517241267005e-42 NA NA NA hsa-miR-183-5p DST 2.95681814393872 1.09965777344285e-92 -2.65768728199613 1.49859497194328e-82 mirMAP -0.431912743648347 2.30351112649499e-45 NA NA NA hsa-miR-200a-3p DST 2.55218480823434 2.96135446816238e-51 -2.65768728199613 1.49859497194328e-82 mirMAP -0.289656110108089 2.18967385872587e-24 NA NA NA hsa-miR-200b-3p DST 2.11744072703209 1.66710572104191e-43 -2.65768728199613 1.49859497194328e-82 mirMAP -0.293585785496736 2.54473459359641e-20 NA NA NA hsa-miR-200c-3p DST 2.07038651806183 6.84613386286599e-51 -2.65768728199613 1.49859497194328e-82 mirMAP -0.367710964272576 2.86982979480575e-26 NA NA NA hsa-miR-21-5p DST 2.32007501846389 3.08394781855554e-137 -2.65768728199613 1.49859497194328e-82 mirMAP -0.658195712040471 2.03281374044393e-48 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-429 DST 2.84108892259147 3.88520896426515e-64 -2.65768728199613 1.49859497194328e-82 miRanda;mirMAP;miRNATAP -0.335369004875444 2.7974997525439e-33 NA NA NA hsa-miR-200c-3p DTNA 2.07038651806183 6.84613386286599e-51 -0.983895543773159 3.56086232599839e-08 MirTarget -0.138865450327607 0.000930379966235622 NA NA NA hsa-miR-429 DTX1 2.84108892259147 3.88520896426515e-64 -2.3363455086237 5.13243982484665e-53 miRNATAP -0.36889863297652 1.0271762703049e-35 NA NA NA hsa-miR-139-5p DTX3L -3.25846663863766 2.62018989415003e-112 0.66046349924901 9.13803430476008e-18 miRanda -0.149123023478464 3.15585944480593e-21 NA NA NA hsa-miR-429 DTX4 2.84108892259147 3.88520896426515e-64 -0.808306262548725 7.43344328322145e-09 miRNATAP -0.162777505930333 7.95453653171061e-10 NA NA NA hsa-miR-141-3p DUSP1 2.99777540204168 1.26370498493024e-78 -2.09516763518402 5.67014496179034e-44 TargetScan -0.440500474854258 4.67394231028638e-52 NA NA NA hsa-miR-200b-3p DUSP1 2.11744072703209 1.66710572104191e-43 -2.09516763518402 5.67014496179034e-44 MirTarget;TargetScan -0.374890795121428 1.11762164968543e-30 NA NA NA hsa-miR-200c-3p DUSP1 2.07038651806183 6.84613386286599e-51 -2.09516763518402 5.67014496179034e-44 MirTarget;miRNATAP -0.461418642771936 8.7350380053437e-39 NA NA NA hsa-miR-429 DUSP1 2.84108892259147 3.88520896426515e-64 -2.09516763518402 5.67014496179034e-44 MirTarget;PITA;miRanda;miRNATAP -0.372780864262415 2.28853225919904e-38 NA NA NA hsa-miR-429 DUSP19 2.84108892259147 3.88520896426515e-64 -0.853343162684792 3.0423077505092e-25 miRanda -0.109950144153454 3.99642360692021e-12 NA NA NA hsa-miR-96-5p DUSP22 3.24596558166606 1.92296159041707e-98 -0.773518937744533 4.22966569757524e-36 TargetScan -0.120897910850384 1.88401790769886e-22 NA NA NA hsa-miR-429 DUSP27 2.84108892259147 3.88520896426515e-64 -0.697498231813856 0.000901555069871731 miRNATAP -0.14608007617499 0.000245313702730543 NA NA NA hsa-miR-141-3p DUSP3 2.99777540204168 1.26370498493024e-78 -0.527416845652245 2.0194487779533e-21 MirTarget;TargetScan;miRNATAP -0.119241384977083 5.00857115800078e-29 NA NA NA hsa-miR-452-5p DUSP4 -2.48486455572568 1.24430987974325e-33 -0.0640801861695559 0.746957922486221 mirMAP -0.168546342430895 8.96343246877319e-08 NA NA NA hsa-miR-10a-5p DVL1 -0.798524155913801 2.99126531473748e-08 0.590824685068987 4.08262080246939e-09 miRNAWalker2_validate -0.107762545824595 6.19772338888115e-06 NA NA NA hsa-miR-30b-3p DVL1 -0.536462824497982 2.41814659272548e-05 0.590824685068987 4.08262080246939e-09 MirTarget -0.115579437179508 2.3800207966178e-05 NA NA NA hsa-miR-339-5p DVL1 -0.211548290465418 0.0685885445822389 0.590824685068987 4.08262080246939e-09 miRanda -0.110559788670663 0.000220610270051997 NA NA NA hsa-let-7a-5p DVL3 -0.210286642041636 0.0072546234707717 0.455328608158929 8.28983754650674e-22 TargetScan -0.103667059737757 1.12037250327915e-06 NA NA NA hsa-miR-486-5p DYDC2 -3.87258704301474 1.22658629378451e-80 1.22499877227168 9.5854875010716e-07 miRanda -0.104805670185313 0.00611746140418084 NA NA NA hsa-miR-141-3p DYNC1I1 2.99777540204168 1.26370498493024e-78 -1.58158153479423 1.8736425450938e-21 MirTarget -0.289847843772981 4.39467889786326e-19 NA NA NA hsa-miR-182-5p DYNC1I1 2.36408084103818 2.60011457600281e-72 -1.58158153479423 1.8736425450938e-21 MirTarget -0.432051790840194 4.52941786939918e-28 NA NA NA hsa-miR-183-5p DYNC1I1 2.95681814393872 1.09965777344285e-92 -1.58158153479423 1.8736425450938e-21 MirTarget -0.380722102430681 7.274675384607e-28 NA NA NA hsa-miR-200a-3p DYNC1I1 2.55218480823434 2.96135446816238e-51 -1.58158153479423 1.8736425450938e-21 MirTarget -0.246463836286345 1.46650798343151e-14 NA NA NA hsa-miR-200b-3p DYNC1I1 2.11744072703209 1.66710572104191e-43 -1.58158153479423 1.8736425450938e-21 MirTarget -0.241032008294904 1.64139559615372e-11 NA NA NA hsa-miR-200c-3p DYNC1I1 2.07038651806183 6.84613386286599e-51 -1.58158153479423 1.8736425450938e-21 MirTarget -0.305316864468734 6.54309610362217e-15 NA NA NA hsa-miR-21-3p DYNC1I1 2.17476065946878 5.15299442583591e-75 -1.58158153479423 1.8736425450938e-21 MirTarget -0.231730970236309 2.11341839815041e-07 NA NA NA hsa-miR-429 DYNC1I1 2.84108892259147 3.88520896426515e-64 -1.58158153479423 1.8736425450938e-21 MirTarget;miRanda -0.227800052892137 9.35063445323269e-13 NA NA NA hsa-miR-21-5p DYNC1LI2 2.32007501846389 3.08394781855554e-137 -0.619955737309359 8.35722155114816e-26 miRNAWalker2_validate -0.191465018085036 2.18459489707379e-25 NA NA NA hsa-miR-429 DYSF 2.84108892259147 3.88520896426515e-64 -0.289012239629203 0.00213379727560717 miRanda -0.108153954448313 9.76675487571601e-10 NA NA NA hsa-miR-141-3p DZIP1 2.99777540204168 1.26370498493024e-78 -1.06531126131458 4.72890562161364e-17 TargetScan;miRNATAP -0.227272656148558 2.44758513161233e-20 NA NA NA hsa-miR-200a-3p DZIP1 2.55218480823434 2.96135446816238e-51 -1.06531126131458 4.72890562161364e-17 miRNATAP -0.22303755512996 2.38751463031969e-20 NA NA NA hsa-miR-200a-5p DZIP1 2.58844508672328 1.79650654234569e-56 -1.06531126131458 4.72890562161364e-17 mirMAP -0.180656433947696 4.45032886000222e-13 NA NA NA hsa-miR-200b-3p DZIP1 2.11744072703209 1.66710572104191e-43 -1.06531126131458 4.72890562161364e-17 MirTarget;TargetScan -0.235396049192488 2.16145312966316e-18 NA NA NA hsa-miR-200c-3p DZIP1 2.07038651806183 6.84613386286599e-51 -1.06531126131458 4.72890562161364e-17 MirTarget -0.252495119306762 1.54084026295551e-17 NA NA NA hsa-miR-429 DZIP1 2.84108892259147 3.88520896426515e-64 -1.06531126131458 4.72890562161364e-17 MirTarget;PITA;miRanda;miRNATAP -0.18626786761918 1.22001045123551e-14 NA NA NA hsa-miR-10b-5p E2F3 -2.10996264627796 7.36811595736367e-72 0.722298179791941 1.47364190074422e-14 miRNATAP -0.259456478181933 7.43240431726397e-26 NA NA NA hsa-miR-145-5p E2F3 -2.62703571936687 7.64402900188551e-88 0.722298179791941 1.47364190074422e-14 miRNATAP -0.119587655423822 5.65169736724442e-08 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-335-5p E2F5 -2.61355235628987 2.6462884165886e-51 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate -0.122773312196824 1.03172977893697e-07 NA NA NA hsa-miR-337-3p E2F5 -2.14274617598363 2.70942896809734e-43 1.22057233889235 9.21129944070499e-24 MirTarget;PITA -0.228149350398858 4.79737697762728e-19 NA NA NA hsa-miR-10b-5p E2F7 -2.10996264627796 7.36811595736367e-72 2.8260144236386 9.30025571255594e-58 miRNATAP -0.701959019063886 3.22236909387654e-49 NA NA NA hsa-miR-139-5p E2F7 -3.25846663863766 2.62018989415003e-112 2.8260144236386 9.30025571255594e-58 miRanda -0.571021926692116 3.28471391513492e-55 NA NA NA hsa-miR-486-5p E2F7 -3.87258704301474 1.22658629378451e-80 2.8260144236386 9.30025571255594e-58 miRanda -0.304107891036698 1.22214576866241e-27 NA NA NA hsa-miR-139-5p E2F8 -3.25846663863766 2.62018989415003e-112 3.45462590495972 1.55343488167226e-63 miRanda -0.657041633931777 6.26667124089891e-53 NA NA NA hsa-miR-99a-5p E4F1 -2.25079447371102 1.14086813185885e-54 1.13423033807856 7.77243065009591e-29 miRNAWalker2_validate -0.218383943745518 9.04583054169899e-22 NA NA NA hsa-miR-182-5p EBF1 2.36408084103818 2.60011457600281e-72 -3.05813406888286 3.48046971181507e-101 miRNATAP -0.571673999021258 2.61373982227729e-56 NA NA NA hsa-miR-429 EBF1 2.84108892259147 3.88520896426515e-64 -3.05813406888286 3.48046971181507e-101 miRanda;miRNATAP -0.522886190471286 4.37050356138878e-78 NA NA NA hsa-miR-96-5p EBF1 3.24596558166606 1.92296159041707e-98 -3.05813406888286 3.48046971181507e-101 TargetScan;miRNATAP -0.563059031467336 2.97006930395485e-84 NA NA NA hsa-miR-200a-5p EBF2 2.58844508672328 1.79650654234569e-56 -2.89413018596655 1.9568541343758e-43 miRNATAP -0.45838613027698 5.60306214079613e-28 NA NA NA hsa-miR-182-5p EBF3 2.36408084103818 2.60011457600281e-72 -2.97501614850151 4.64775706799242e-84 MirTarget;miRNATAP -0.531261111316508 2.53733753773733e-43 NA NA NA hsa-miR-21-3p EBF3 2.17476065946878 5.15299442583591e-75 -2.97501614850151 4.64775706799242e-84 mirMAP -0.617367389773017 2.362904109548e-48 NA NA NA hsa-miR-375 EBF3 2.09893673049766 1.68351780396203e-16 -2.97501614850151 4.64775706799242e-84 miRanda;miRNATAP -0.159959488065909 5.47944924917584e-13 NA NA NA hsa-miR-429 EBF3 2.84108892259147 3.88520896426515e-64 -2.97501614850151 4.64775706799242e-84 miRanda;miRNATAP -0.496431211670637 4.930196524188e-62 NA NA NA hsa-miR-96-5p EBF3 3.24596558166606 1.92296159041707e-98 -2.97501614850151 4.64775706799242e-84 MirTarget;TargetScan;miRNATAP -0.535548399152131 5.96684757748495e-67 NA NA NA hsa-miR-337-3p ECE2 -2.14274617598363 2.70942896809734e-43 1.88998032444021 3.07083280596461e-54 PITA -0.316255820078307 1.61504111639949e-33 NA NA NA hsa-miR-196a-5p ECHDC1 2.33423717464504 3.646557504928e-18 -1.33477016109512 1.26116853565045e-38 miRNAWalker2_validate -0.103351383057297 5.53782384023891e-15 NA NA NA hsa-miR-141-5p EDA 2.38411349683216 4.56310582620282e-58 -1.63641912106552 3.36259746284007e-42 mirMAP -0.285865296139505 2.04493156261274e-27 NA NA NA hsa-miR-182-5p EDA 2.36408084103818 2.60011457600281e-72 -1.63641912106552 3.36259746284007e-42 mirMAP -0.280447714214165 1.78499743204248e-21 NA NA NA hsa-miR-429 EDA 2.84108892259147 3.88520896426515e-64 -1.63641912106552 3.36259746284007e-42 miRNATAP -0.244863910056021 7.44289210635447e-26 NA NA NA hsa-miR-96-5p EDA 3.24596558166606 1.92296159041707e-98 -1.63641912106552 3.36259746284007e-42 mirMAP -0.278166654715284 1.09845831885374e-30 NA NA NA hsa-miR-429 EDA2R 2.84108892259147 3.88520896426515e-64 -1.34255111275385 3.98620322593049e-21 miRanda -0.22398837783932 1.6202703908618e-16 NA NA NA hsa-miR-182-5p EDIL3 2.36408084103818 2.60011457600281e-72 -0.548013396950836 0.0239358726421537 MirTarget -0.154224143674225 0.00772099786995928 NA NA NA hsa-miR-429 EDN1 2.84108892259147 3.88520896426515e-64 -1.72115310703749 1.9106679470357e-25 miRNATAP -0.158337265054084 8.10254784021096e-07 NA NA NA hsa-miR-375 EDN3 2.09893673049766 1.68351780396203e-16 -4.59497689622819 4.8661615450989e-32 miRanda -0.385116651948935 3.08819018387424e-13 NA NA NA hsa-miR-200c-3p EDNRA 2.07038651806183 6.84613386286599e-51 -0.14153486543887 0.241849668080954 miRNAWalker2_validate;miRNATAP -0.2381009935223 7.07311760507522e-18 NA NA NA hsa-miR-429 EDNRA 2.84108892259147 3.88520896426515e-64 -0.14153486543887 0.241849668080954 miRanda;miRNATAP -0.166807965028777 1.48190136605579e-13 NA NA NA hsa-miR-96-5p EDNRA 3.24596558166606 1.92296159041707e-98 -0.14153486543887 0.241849668080954 TargetScan -0.135940967795005 9.92300119585494e-09 NA NA NA hsa-miR-182-5p EDNRB 2.36408084103818 2.60011457600281e-72 -2.53325707381385 5.68707207810449e-66 miRNATAP -0.360880004393659 3.85801534301098e-22 NA NA NA hsa-miR-96-5p EDNRB 3.24596558166606 1.92296159041707e-98 -2.53325707381385 5.68707207810449e-66 miRNATAP -0.380436125230381 5.95245468090418e-36 NA NA NA hsa-miR-182-5p EEA1 2.36408084103818 2.60011457600281e-72 -0.917079076269 8.13513862826476e-26 miRNATAP -0.120511658882 1.51481739703351e-08 NA NA NA hsa-miR-96-5p EEA1 3.24596558166606 1.92296159041707e-98 -0.917079076269 8.13513862826476e-26 TargetScan;miRNATAP -0.15434559101826 8.30119775638893e-19 NA NA NA hsa-miR-21-3p EEF2K 2.17476065946878 5.15299442583591e-75 -0.486946990827098 3.51444603027139e-13 MirTarget -0.153480702492772 1.73093520780636e-18 NA NA NA hsa-miR-335-5p EFNA1 -2.61355235628987 2.6462884165886e-51 1.03416794486437 5.98415403389838e-26 miRNAWalker2_validate -0.128525356807881 4.72540778045499e-12 NA NA NA hsa-miR-486-5p EFNA1 -3.87258704301474 1.22658629378451e-80 1.03416794486437 5.98415403389838e-26 miRanda -0.133549219076437 7.71718683921977e-19 NA NA NA hsa-miR-145-5p EFNA3 -2.62703571936687 7.64402900188551e-88 1.58152606743336 5.43547499348979e-24 miRNATAP -0.225183758775436 1.30937642878182e-09 NA NA NA hsa-miR-486-5p EFNA3 -3.87258704301474 1.22658629378451e-80 1.58152606743336 5.43547499348979e-24 miRanda -0.24448323270154 9.12226705330056e-25 NA NA NA hsa-miR-182-5p EFNA5 2.36408084103818 2.60011457600281e-72 -1.37163072863579 4.49535560121869e-12 mirMAP;miRNATAP -0.345456013207985 2.56625510585803e-13 NA NA NA hsa-miR-200c-3p EFNA5 2.07038651806183 6.84613386286599e-51 -1.37163072863579 4.49535560121869e-12 miRNATAP -0.128934276846316 0.00592726380694451 NA NA NA hsa-miR-21-3p EFNA5 2.17476065946878 5.15299442583591e-75 -1.37163072863579 4.49535560121869e-12 mirMAP -0.134722543252822 0.0108695049986002 NA NA NA hsa-miR-96-5p EFNA5 3.24596558166606 1.92296159041707e-98 -1.37163072863579 4.49535560121869e-12 TargetScan -0.238628836115784 1.35928421306458e-09 NA NA NA hsa-miR-141-5p EFNB2 2.38411349683216 4.56310582620282e-58 -0.897920611264786 1.38298319936521e-15 miRNATAP -0.148448880841912 1.10046735836452e-09 NA NA NA hsa-miR-182-5p EFNB2 2.36408084103818 2.60011457600281e-72 -0.897920611264786 1.38298319936521e-15 miRNATAP -0.154619586773512 1.10675045819458e-08 NA NA NA hsa-miR-200b-3p EFNB2 2.11744072703209 1.66710572104191e-43 -0.897920611264786 1.38298319936521e-15 TargetScan -0.153669839656411 1.61131127652127e-10 NA NA NA hsa-miR-200c-3p EFNB2 2.07038651806183 6.84613386286599e-51 -0.897920611264786 1.38298319936521e-15 miRNATAP -0.186700234716791 1.39840372693239e-12 NA NA NA hsa-miR-429 EFNB2 2.84108892259147 3.88520896426515e-64 -0.897920611264786 1.38298319936521e-15 PITA;miRanda;miRNATAP -0.166121979536751 6.91535992502539e-15 NA NA NA hsa-miR-96-5p EFNB2 3.24596558166606 1.92296159041707e-98 -0.897920611264786 1.38298319936521e-15 miRNAWalker2_validate;TargetScan;miRNATAP -0.155159332686662 3.87729358714953e-12 NA NA NA hsa-miR-429 EFNB3 2.84108892259147 3.88520896426515e-64 -1.46127308517026 6.88852125012967e-17 miRNATAP -0.206592556013673 7.05332662496379e-10 NA NA NA hsa-miR-224-5p EFR3B -2.22249420723892 1.07787949391113e-18 0.730193640676275 4.13434721202402e-06 MirTarget -0.165720644300769 1.97418407967108e-15 NA NA NA hsa-miR-429 EGFLAM 2.84108892259147 3.88520896426515e-64 -1.83726451564372 7.33163953346229e-59 miRNATAP -0.315452071519448 3.33595529116474e-47 NA NA NA hsa-miR-141-3p EGFR 2.99777540204168 1.26370498493024e-78 -3.35228711557446 2.81857446737209e-45 MirTarget -0.586858650420638 4.17631860777935e-36 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-141-5p EGFR 2.38411349683216 4.56310582620282e-58 -3.35228711557446 2.81857446737209e-45 MirTarget -0.540232230964423 7.07290618976338e-25 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-200a-3p EGFR 2.55218480823434 2.96135446816238e-51 -3.35228711557446 2.81857446737209e-45 MirTarget -0.529702964197266 2.19864859009139e-30 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-21-5p EGFR 2.32007501846389 3.08394781855554e-137 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate;miRTarBase -0.671030468978973 2.34536849626451e-18 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-375 EGFR 2.09893673049766 1.68351780396203e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.424868499428666 2.03176717536657e-41 NA NA NA hsa-miR-183-5p EGR1 2.95681814393872 1.09965777344285e-92 -2.86869177371485 1.0832023819925e-54 miRNAWalker2_validate;miRTarBase;miRNATAP -0.572115496113013 2.98432133060609e-48 NA NA NA hsa-miR-429 EGR1 2.84108892259147 3.88520896426515e-64 -2.86869177371485 1.0832023819925e-54 PITA;miRanda -0.44026978254159 1.2100273574456e-34 NA NA NA hsa-miR-141-3p EGR2 2.99777540204168 1.26370498493024e-78 -2.23233044425839 1.40886014268655e-41 TargetScan;miRNATAP -0.346887219038254 4.29424042861336e-26 NA NA NA hsa-miR-200a-3p EGR2 2.55218480823434 2.96135446816238e-51 -2.23233044425839 1.40886014268655e-41 miRNATAP -0.269145922896662 1.57570976681187e-16 NA NA NA hsa-miR-182-5p EGR3 2.36408084103818 2.60011457600281e-72 -2.44968774088166 1.03461455370655e-31 MirTarget -0.344948788380511 1.68040077277067e-11 NA NA NA hsa-miR-200b-3p EGR3 2.11744072703209 1.66710572104191e-43 -2.44968774088166 1.03461455370655e-31 TargetScan -0.225044430748795 9.45788374247688e-07 NA NA NA hsa-miR-429 EGR3 2.84108892259147 3.88520896426515e-64 -2.44968774088166 1.03461455370655e-31 PITA;miRanda;miRNATAP -0.313343072256927 1.12074863057309e-14 NA NA NA hsa-miR-96-5p EGR3 3.24596558166606 1.92296159041707e-98 -2.44968774088166 1.03461455370655e-31 TargetScan -0.416066278462155 2.81056497092235e-23 NA NA NA hsa-miR-335-5p EHBP1L1 -2.61355235628987 2.6462884165886e-51 0.175765544468424 0.0908007606691607 miRNAWalker2_validate -0.102700290290057 8.55415784198621e-08 NA NA NA hsa-miR-21-5p EIF1AX 2.32007501846389 3.08394781855554e-137 -0.253966508578931 6.35019207110812e-06 miRNATAP -0.168398476195986 7.98842147428409e-23 NA NA NA hsa-miR-139-5p EIF2AK2 -3.25846663863766 2.62018989415003e-112 0.439101561695507 1.44591547793053e-05 mirMAP -0.148107185225186 7.61176891834414e-13 NA NA NA hsa-miR-139-5p EIF3H -3.25846663863766 2.62018989415003e-112 0.477068104870117 3.6889098430392e-08 miRanda -0.153954562274618 2.26580048437421e-18 NA NA NA hsa-miR-21-5p EIF4A2 2.32007501846389 3.08394781855554e-137 -0.458685981744615 6.79854430864405e-14 miRNAWalker2_validate;miRTarBase -0.220040692361575 2.91919563506492e-32 NA NA NA hsa-miR-141-3p EIF4E3 2.99777540204168 1.26370498493024e-78 -1.14472452087938 6.75636040536301e-35 mirMAP -0.217157198895305 3.95442611475688e-33 NA NA NA hsa-miR-182-5p EIF4E3 2.36408084103818 2.60011457600281e-72 -1.14472452087938 6.75636040536301e-35 mirMAP -0.130933065862485 1.12758762707797e-08 NA NA NA hsa-miR-200a-3p EIF4E3 2.55218480823434 2.96135446816238e-51 -1.14472452087938 6.75636040536301e-35 mirMAP -0.148264190141239 3.35037951163213e-16 NA NA NA hsa-miR-200b-3p EIF4E3 2.11744072703209 1.66710572104191e-43 -1.14472452087938 6.75636040536301e-35 TargetScan -0.163275109385133 6.67952122506921e-16 NA NA NA hsa-miR-429 EIF4E3 2.84108892259147 3.88520896426515e-64 -1.14472452087938 6.75636040536301e-35 miRanda;miRNATAP -0.181196428125741 3.38685536474498e-24 NA NA NA hsa-miR-96-5p EIF4E3 3.24596558166606 1.92296159041707e-98 -1.14472452087938 6.75636040536301e-35 mirMAP -0.169037039878635 2.01826057062959e-19 NA NA NA hsa-miR-141-3p EIF4EBP2 2.99777540204168 1.26370498493024e-78 -1.00706941701809 2.99774215783787e-56 TargetScan -0.137389399519544 1.3326057443494e-26 NA NA NA hsa-miR-182-5p EIF4EBP2 2.36408084103818 2.60011457600281e-72 -1.00706941701809 2.99774215783787e-56 miRNATAP -0.146374047962199 3.60381791948644e-20 NA NA NA hsa-miR-21-5p EIF4EBP2 2.32007501846389 3.08394781855554e-137 -1.00706941701809 2.99774215783787e-56 miRNAWalker2_validate -0.350566374017919 1.0351546276547e-72 NA NA NA hsa-miR-429 EIF4EBP2 2.84108892259147 3.88520896426515e-64 -1.00706941701809 2.99774215783787e-56 miRNATAP -0.125768300034302 1.72918507741791e-23 NA NA NA hsa-miR-96-5p EIF4EBP2 3.24596558166606 1.92296159041707e-98 -1.00706941701809 2.99774215783787e-56 MirTarget;TargetScan;miRNATAP -0.135675365321007 4.4738230611713e-25 NA NA NA hsa-miR-21-5p EIF5 2.32007501846389 3.08394781855554e-137 -0.284104027351748 3.92073316380084e-07 miRNAWalker2_validate -0.142310267973582 1.37631827729038e-16 NA NA NA hsa-miR-99a-5p EIF5A -2.25079447371102 1.14086813185885e-54 0.728958616306601 1.05203738859209e-23 miRNAWalker2_validate -0.160178670738556 2.46695018692519e-23 NA NA NA hsa-miR-182-5p EIF5A2 2.36408084103818 2.60011457600281e-72 -0.703062291462043 3.31218903549966e-11 mirMAP -0.250774984113832 6.31734460336433e-24 NA NA NA hsa-miR-429 EIF5A2 2.84108892259147 3.88520896426515e-64 -0.703062291462043 3.31218903549966e-11 miRanda;miRNATAP -0.179466860047189 1.75031606479805e-19 NA NA NA hsa-miR-10b-5p ELAVL2 -2.10996264627796 7.36811595736367e-72 1.79150309186385 3.81275176546331e-16 MirTarget;miRNATAP -0.479756566476995 3.03613231891295e-16 NA NA NA hsa-miR-139-5p ELAVL2 -3.25846663863766 2.62018989415003e-112 1.79150309186385 3.81275176546331e-16 MirTarget;PITA;miRanda;miRNATAP -0.34831212575775 1.82431170979586e-14 NA NA NA hsa-miR-452-5p ELAVL2 -2.48486455572568 1.24430987974325e-33 1.79150309186385 3.81275176546331e-16 MirTarget;miRNATAP -0.137355130969077 0.000121853179990045 NA NA NA hsa-miR-486-5p ELAVL2 -3.87258704301474 1.22658629378451e-80 1.79150309186385 3.81275176546331e-16 PITA;miRanda;miRNATAP -0.163409832709258 1.43072020610792e-06 NA NA NA hsa-miR-21-5p ELF2 2.32007501846389 3.08394781855554e-137 -0.324906584159017 3.77461367174443e-10 MirTarget;miRNATAP -0.171993160350573 1.0473729881449e-27 NA NA NA hsa-miR-139-5p ELF3 -3.25846663863766 2.62018989415003e-112 1.43578153564253 3.59828634808815e-19 miRanda -0.235705639877741 1.62398334577205e-12 NA NA NA hsa-miR-145-5p ELFN2 -2.62703571936687 7.64402900188551e-88 1.01161197521848 6.69138142173359e-05 mirMAP -0.136585235242268 0.0211028981996716 NA NA NA hsa-miR-378a-5p ELFN2 -2.43173551693523 1.44932837789175e-68 1.01161197521848 6.69138142173359e-05 mirMAP -0.282350877215824 8.71021403339463e-07 NA NA NA hsa-miR-452-5p ELFN2 -2.48486455572568 1.24430987974325e-33 1.01161197521848 6.69138142173359e-05 miRNATAP -0.101606338660021 0.0126173282075685 NA NA NA hsa-miR-141-3p ELK3 2.99777540204168 1.26370498493024e-78 -0.902894075580307 3.57638726412939e-16 TargetScan -0.25004057553603 2.04702449975357e-32 NA NA NA hsa-miR-200b-3p ELK3 2.11744072703209 1.66710572104191e-43 -0.902894075580307 3.57638726412939e-16 TargetScan -0.223736974181422 9.26437402081844e-22 NA NA NA hsa-miR-210-3p ELK3 2.38367203491819 3.73261999106754e-22 -0.902894075580307 3.57638726412939e-16 miRNAWalker2_validate -0.11511369164451 1.96131934281268e-14 NA NA NA hsa-miR-429 ELK3 2.84108892259147 3.88520896426515e-64 -0.902894075580307 3.57638726412939e-16 miRanda;miRNATAP -0.222708469159484 5.40518801611261e-27 NA NA NA hsa-miR-200b-3p ELL2 2.11744072703209 1.66710572104191e-43 -0.464211798623089 6.21722889684294e-06 MirTarget;TargetScan -0.111914987066807 2.73779968442616e-07 NA NA NA hsa-miR-200c-3p ELL2 2.07038651806183 6.84613386286599e-51 -0.464211798623089 6.21722889684294e-06 MirTarget -0.121169417275693 4.18860520613644e-07 NA NA NA hsa-miR-182-5p ELMO1 2.36408084103818 2.60011457600281e-72 -0.756820250745317 7.97666481315279e-15 MirTarget -0.239553100995718 1.33167885762678e-25 NA NA NA hsa-miR-21-3p ELMO1 2.17476065946878 5.15299442583591e-75 -0.756820250745317 7.97666481315279e-15 MirTarget -0.106888890393141 3.92910390280603e-05 NA NA NA hsa-miR-429 ELMO1 2.84108892259147 3.88520896426515e-64 -0.756820250745317 7.97666481315279e-15 miRanda -0.17717818447629 3.39417554042431e-22 NA NA NA hsa-miR-96-5p ELMO1 3.24596558166606 1.92296159041707e-98 -0.756820250745317 7.97666481315279e-15 TargetScan -0.19844362767521 1.6114960433292e-25 NA NA NA hsa-miR-429 ELN 2.84108892259147 3.88520896426515e-64 -0.310025781931611 0.132934884857683 miRNATAP -0.258833056070117 2.14430384622947e-11 NA NA NA hsa-miR-452-5p ELOVL5 -2.48486455572568 1.24430987974325e-33 -0.303052367414431 0.0214705661280659 MirTarget -0.157729717826227 3.0532743155437e-14 NA NA NA hsa-miR-10b-5p ELOVL6 -2.10996264627796 7.36811595736367e-72 0.361520680583945 0.00511417852010313 miRNATAP -0.137854560136499 6.05133353277668e-05 NA NA NA hsa-miR-21-5p ELOVL7 2.32007501846389 3.08394781855554e-137 -1.01416987624799 6.5395951684739e-11 miRNAWalker2_validate -0.23921022619148 9.19094815006121e-07 NA NA NA hsa-miR-200b-3p EMB 2.11744072703209 1.66710572104191e-43 -0.149671804994488 0.294307117637889 TargetScan -0.107030374279729 0.000396055731503279 NA NA NA hsa-miR-139-5p EME1 -3.25846663863766 2.62018989415003e-112 2.43468682006002 2.34071521689393e-60 MirTarget;miRanda -0.500071568810124 7.10989486290422e-60 NA NA NA hsa-miR-486-5p EME1 -3.87258704301474 1.22658629378451e-80 2.43468682006002 2.34071521689393e-60 miRanda -0.256898855433917 1.24807887981022e-27 NA NA NA hsa-miR-96-5p EML5 3.24596558166606 1.92296159041707e-98 -1.0592648824178 2.68815536849267e-25 TargetScan -0.104181930752409 4.60118288097562e-07 NA NA NA hsa-miR-375 EMP1 2.09893673049766 1.68351780396203e-16 -1.83167983014907 5.40973062375854e-52 miRNAWalker2_validate -0.21036488131413 1.88366741193279e-38 NA NA NA hsa-miR-429 EMP1 2.84108892259147 3.88520896426515e-64 -1.83167983014907 5.40973062375854e-52 miRanda -0.314933735920698 5.25703820119027e-42 NA NA NA hsa-miR-139-5p EMX1 -3.25846663863766 2.62018989415003e-112 2.61549251194819 3.09217153380424e-14 PITA;miRanda -0.31225078645849 1.38170942773116e-05 NA NA NA hsa-miR-429 EMX2 2.84108892259147 3.88520896426515e-64 -1.6140000804911 1.94737922809808e-22 miRNATAP -0.358266166983077 9.39635574608006e-31 NA NA NA hsa-miR-139-5p EN1 -3.25846663863766 2.62018989415003e-112 0.174210887189493 0.504134293129517 miRanda -0.148463183298539 0.00566694627249528 NA NA NA hsa-miR-429 EN2 2.84108892259147 3.88520896426515e-64 -0.871567338784618 0.00277708727581673 miRanda;miRNATAP -0.142101382241309 0.0102103203543594 NA NA NA hsa-miR-139-5p ENAH -3.25846663863766 2.62018989415003e-112 0.621661196819598 3.34692657444668e-12 PITA;miRNATAP -0.143228127519648 5.4236807474444e-15 NA NA NA hsa-miR-200b-3p ENPEP 2.11744072703209 1.66710572104191e-43 -0.841847912753876 5.14436160563452e-12 mirMAP -0.262531057191957 6.36435363001191e-25 NA NA NA hsa-miR-429 ENPEP 2.84108892259147 3.88520896426515e-64 -0.841847912753876 5.14436160563452e-12 miRanda;mirMAP -0.211356717796871 2.49763918765744e-20 NA NA NA hsa-miR-429 ENPP2 2.84108892259147 3.88520896426515e-64 -3.08067150831063 2.81219277619852e-74 miRanda -0.487539392440326 4.12819154616727e-49 NA NA NA hsa-miR-429 ENPP3 2.84108892259147 3.88520896426515e-64 -1.69498383849612 1.34917226488226e-12 miRanda -0.164566914944829 0.000333072823292396 NA NA NA hsa-miR-429 ENPP6 2.84108892259147 3.88520896426515e-64 -1.63451763932071 1.02040346655022e-22 miRNATAP -0.205936079810436 1.43773407159035e-10 NA NA NA hsa-miR-429 ENTPD3 2.84108892259147 3.88520896426515e-64 -0.701514453807539 0.000668952813486322 miRanda -0.168450028129886 1.59772255507436e-05 NA NA NA hsa-miR-144-5p ENTPD7 -2.75914786146772 1.55794225315972e-50 1.15485276182783 2.57763500620378e-35 MirTarget -0.147337024566385 6.63399839012059e-19 NA NA NA hsa-miR-10b-5p ENTPD8 -2.10996264627796 7.36811595736367e-72 2.42374235650426 4.30860549905381e-17 mirMAP -0.205393727694113 0.00883576710484613 NA NA NA hsa-miR-182-5p EOMES 2.36408084103818 2.60011457600281e-72 0.484857265100818 0.0285490983936263 MirTarget -0.128818741053529 0.0147599365952673 NA NA NA hsa-miR-96-5p EOMES 3.24596558166606 1.92296159041707e-98 0.484857265100818 0.0285490983936263 MirTarget;TargetScan -0.139224739299463 0.00147357605867997 NA NA NA hsa-miR-106b-5p EP300 1.22477789913175 2.31787213143326e-32 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.191649543350323 2.95239597393248e-13 NA NA NA hsa-miR-181b-5p EP300 1.22749257795094 1.21998198830919e-27 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 NA NA NA hsa-miR-20a-5p EP300 0.44979911120222 0.000602386964327228 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.151748232339608 1.59846335234487e-12 NA NA NA hsa-miR-25-3p EP300 -0.00546790775985073 0.944061771389468 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 NA NA NA hsa-miR-361-3p EP300 -0.0370446538644886 0.624902392829872 -0.378121576001413 5.1159454625656e-06 PITA -0.139187579360879 0.000249736724501524 NA NA NA hsa-miR-182-5p EPAS1 2.36408084103818 2.60011457600281e-72 -1.90587270160478 6.25732572832899e-70 MirTarget;miRNATAP -0.361618466225692 6.5467448627672e-42 NA NA NA hsa-miR-21-3p EPAS1 2.17476065946878 5.15299442583591e-75 -1.90587270160478 6.25732572832899e-70 MirTarget -0.322540476247534 6.82656567976347e-27 NA NA NA hsa-miR-429 EPAS1 2.84108892259147 3.88520896426515e-64 -1.90587270160478 6.25732572832899e-70 miRanda -0.358836959737799 8.26416214768682e-69 NA NA NA hsa-miR-96-5p EPAS1 3.24596558166606 1.92296159041707e-98 -1.90587270160478 6.25732572832899e-70 TargetScan;miRNATAP -0.35566276955952 4.9691661077499e-61 NA NA NA hsa-miR-141-3p EPB41L3 2.99777540204168 1.26370498493024e-78 -0.754440114178199 1.08976310012052e-09 miRNATAP -0.193180613266036 6.1248092441496e-16 NA NA NA hsa-miR-200a-3p EPB41L3 2.55218480823434 2.96135446816238e-51 -0.754440114178199 1.08976310012052e-09 miRNATAP -0.175535900400833 8.09800571974403e-14 NA NA NA hsa-miR-96-5p EPB41L3 3.24596558166606 1.92296159041707e-98 -0.754440114178199 1.08976310012052e-09 MirTarget;TargetScan;miRNATAP -0.145667304305254 2.80482569714615e-09 NA NA NA hsa-miR-21-3p EPC2 2.17476065946878 5.15299442583591e-75 -0.613413761634052 1.30752456183841e-21 MirTarget -0.104316659348446 1.23605026703182e-09 NA NA NA hsa-miR-141-5p EPDR1 2.38411349683216 4.56310582620282e-58 -1.81117430039737 1.95042630036804e-37 MirTarget -0.403732592757794 2.13747006701749e-40 NA NA NA hsa-miR-182-5p EPDR1 2.36408084103818 2.60011457600281e-72 -1.81117430039737 1.95042630036804e-37 MirTarget -0.433597032131614 1.04788297454788e-37 NA NA NA hsa-miR-429 EPDR1 2.84108892259147 3.88520896426515e-64 -1.81117430039737 1.95042630036804e-37 miRanda -0.342852863861859 2.73587117585581e-37 NA NA NA hsa-miR-335-5p EPHA1 -2.61355235628987 2.6462884165886e-51 1.34615829502684 4.24914616236352e-27 miRNAWalker2_validate -0.156347516264999 4.37204514800506e-11 NA NA NA hsa-miR-335-5p EPHA10 -2.61355235628987 2.6462884165886e-51 1.91858997883862 2.37765382095799e-22 mirMAP -0.206239196261889 3.51455984658558e-08 NA NA NA hsa-miR-141-3p EPHA2 2.99777540204168 1.26370498493024e-78 -1.25921912819417 1.34618358519816e-29 MirTarget;TargetScan;miRNATAP -0.184299260927489 6.45342555838155e-17 24647573 miR 141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression; In addition a specific and inverse correlation between miR-141 and EphA2 expression was obtained in human ccRCC samples metastasis kidney renal cell cancer hsa-miR-200a-3p EPHA2 2.55218480823434 2.96135446816238e-51 -1.25921912819417 1.34618358519816e-29 MirTarget;miRNATAP -0.119330959159105 5.02146466331342e-08 22562546;26088362;24503464 Our studies propose EphA2 as a novel and important target gene for miR-200a;miR 200a inhibits migration of triple negative breast cancer cells through direct repression of the EPHA2 oncogene; We show that EPHA2 expression is correlated with poor survival specifically in basal-like breast cancer and that its expression is repressed by miR-200a through direct interaction with the 3'UTR of EPHA2; We establish that miR-200a directs cell migration in a dual manner; in addition to regulating the well-characterized E-cadherin pathway it also regulates a EPHA2 pathway;In addition our results suggested that miR-200a inhibited VM by negatively regulated EphA2 expression; Consistently the inverse correlation of miR-200a and EphA2 has also been found in ovarian cancer patients; Our research demonstrates that VM miR-200a and EphA2 play key roles in the progression and prognosis of ovarian cancer and for the first time suggests that miR-200a inhibits VM by directly regulating EphA2 ;poor survival;cell migration;progression;worse prognosis breast cancer;breast cancer;ovarian cancer hsa-miR-182-5p EPHA3 2.36408084103818 2.60011457600281e-72 -0.830979412970837 4.29268925743742e-05 miRNATAP -0.215472737253014 8.63572701013271e-06 NA NA NA hsa-miR-429 EPHA3 2.84108892259147 3.88520896426515e-64 -0.830979412970837 4.29268925743742e-05 miRanda -0.288257669585333 3.72857420640721e-14 NA NA NA hsa-miR-96-5p EPHA3 3.24596558166606 1.92296159041707e-98 -0.830979412970837 4.29268925743742e-05 MirTarget;TargetScan;miRNATAP -0.25656466132349 1.32137298469047e-10 NA NA NA hsa-miR-141-3p EPHA4 2.99777540204168 1.26370498493024e-78 -1.55269305526411 1.14762781890163e-27 mirMAP -0.270231620886409 3.81760465217483e-22 NA NA NA hsa-miR-183-5p EPHA4 2.95681814393872 1.09965777344285e-92 -1.55269305526411 1.14762781890163e-27 miRNATAP -0.300456975996119 2.84063628927367e-23 NA NA NA hsa-miR-200a-3p EPHA4 2.55218480823434 2.96135446816238e-51 -1.55269305526411 1.14762781890163e-27 mirMAP -0.208535410030764 5.10863335620484e-14 NA NA NA hsa-miR-21-5p EPHA4 2.32007501846389 3.08394781855554e-137 -1.55269305526411 1.14762781890163e-27 miRNAWalker2_validate;miRNATAP -0.395716480858847 1.43468003643289e-18 NA NA NA hsa-miR-429 EPHA4 2.84108892259147 3.88520896426515e-64 -1.55269305526411 1.14762781890163e-27 miRanda -0.211586217249299 1.38795316095178e-14 NA NA NA hsa-miR-141-3p EPHA7 2.99777540204168 1.26370498493024e-78 -2.17929070247088 6.15153712858751e-18 TargetScan;miRNATAP -0.202168479891777 5.29928810824267e-05 26261572 Among those the expression of EPHA7 and PI15 were negatively correlated with that of microRNA-141 and they were also identified as potential targets of this microRNA via microRNA-mRNA interaction; We thus concluded that microRNA-141 EPHA7 and PI15 might jointly participate in the regulation of drug resistance in ovarian cancer and serve as potential targets in targeted therapies drug resistance ovarian cancer hsa-miR-182-5p EPHA7 2.36408084103818 2.60011457600281e-72 -2.17929070247088 6.15153712858751e-18 miRNATAP -0.369137142776005 1.38808171180411e-09 NA NA NA hsa-miR-200a-3p EPHA7 2.55218480823434 2.96135446816238e-51 -2.17929070247088 6.15153712858751e-18 miRNATAP -0.201909951301785 3.86585377960352e-05 NA NA NA hsa-miR-429 EPHA7 2.84108892259147 3.88520896426515e-64 -2.17929070247088 6.15153712858751e-18 miRNATAP -0.165776930294085 0.000682143250047769 NA NA NA hsa-miR-10b-5p EPHA8 -2.10996264627796 7.36811595736367e-72 2.76055932726438 1.66271273677373e-18 miRNATAP -0.53582624479491 2.73022902248151e-10 NA NA NA hsa-miR-182-5p EPHB1 2.36408084103818 2.60011457600281e-72 -2.96143145324785 4.99337688789529e-54 MirTarget;miRNATAP -0.659855852017394 1.90272073541793e-46 NA NA NA hsa-miR-96-5p EPHB1 3.24596558166606 1.92296159041707e-98 -2.96143145324785 4.99337688789529e-54 miRNATAP -0.550603418605534 5.06653702810751e-47 NA NA NA hsa-miR-141-5p EPHX1 2.38411349683216 4.56310582620282e-58 -0.460400217402894 2.60783263652685e-05 MirTarget -0.160716000727625 5.64539961497138e-12 NA NA NA hsa-miR-182-5p EPM2A 2.36408084103818 2.60011457600281e-72 -1.03058341033904 4.22153693157503e-43 miRNATAP -0.144915413152825 5.00931323708651e-15 NA NA NA hsa-miR-21-5p EPM2A 2.32007501846389 3.08394781855554e-137 -1.03058341033904 4.22153693157503e-43 miRNAWalker2_validate -0.371811814361254 1.51752561454969e-59 NA NA NA hsa-miR-21-3p EPM2AIP1 2.17476065946878 5.15299442583591e-75 -0.437165458818003 3.86366376911147e-08 MirTarget -0.105363364196612 5.053101316078e-07 NA NA NA hsa-miR-21-5p EPM2AIP1 2.32007501846389 3.08394781855554e-137 -0.437165458818003 3.86366376911147e-08 mirMAP -0.202953899150199 1.2516439307061e-16 NA NA NA hsa-miR-200c-3p EPS15 2.07038651806183 6.84613386286599e-51 -0.538952390087797 1.11283135329341e-25 miRNATAP -0.11218100530384 1.35240399026933e-20 NA NA NA hsa-miR-200b-3p EPS8 2.11744072703209 1.66710572104191e-43 -1.29357672864563 9.19667810429944e-38 TargetScan -0.222770622409352 1.29551602210027e-24 NA NA NA hsa-miR-429 EPS8 2.84108892259147 3.88520896426515e-64 -1.29357672864563 9.19667810429944e-38 PITA;miRanda -0.204497263705319 5.22180043100412e-26 NA NA NA hsa-miR-141-3p ERAP1 2.99777540204168 1.26370498493024e-78 -0.852967400200354 3.24611004098298e-23 mirMAP -0.162369024005508 2.94343159617141e-22 NA NA NA hsa-miR-96-5p ERAP2 3.24596558166606 1.92296159041707e-98 -0.452848732400117 0.0348105586904004 miRNATAP -0.108686457280145 0.0104853618124729 NA NA NA hsa-miR-429 ERBB4 2.84108892259147 3.88520896426515e-64 -0.949260076610313 0.006124970228615 PITA;miRanda;miRNATAP -0.132997468006583 0.0431936949788559 NA NA NA hsa-miR-452-5p ERBB4 -2.48486455572568 1.24430987974325e-33 -0.949260076610313 0.006124970228615 mirMAP -0.701884213446386 2.37990608843616e-40 NA NA NA hsa-miR-141-3p ERC2 2.99777540204168 1.26370498493024e-78 -0.812202529557805 1.35392004141974e-06 MirTarget;TargetScan -0.115370146339723 0.000441406748997662 NA NA NA hsa-miR-182-5p ERC2 2.36408084103818 2.60011457600281e-72 -0.812202529557805 1.35392004141974e-06 miRNATAP -0.19178321871439 1.75209138968011e-06 NA NA NA hsa-miR-96-5p ERC2 3.24596558166606 1.92296159041707e-98 -0.812202529557805 1.35392004141974e-06 MirTarget;TargetScan;miRNATAP -0.168081581202622 4.34898458323155e-07 NA NA NA hsa-miR-145-5p ERF -2.62703571936687 7.64402900188551e-88 0.413876366387316 1.25066851005599e-07 MirTarget;miRNATAP -0.133841398074238 1.20750260693153e-13 NA NA NA hsa-miR-141-3p ERG 2.99777540204168 1.26370498493024e-78 -1.79406293965654 1.24967833223395e-59 MirTarget;TargetScan -0.413428999029842 3.1789426836235e-89 NA NA NA hsa-miR-182-5p ERG 2.36408084103818 2.60011457600281e-72 -1.79406293965654 1.24967833223395e-59 mirMAP -0.320293041139954 6.40391076611642e-32 NA NA NA hsa-miR-200a-3p ERG 2.55218480823434 2.96135446816238e-51 -1.79406293965654 1.24967833223395e-59 MirTarget -0.328940902899517 1.91474004559624e-54 NA NA NA hsa-miR-200b-3p ERG 2.11744072703209 1.66710572104191e-43 -1.79406293965654 1.24967833223395e-59 TargetScan -0.341571622032645 8.79750059022519e-47 27191272 The tumor suppressive miR 200b subfamily is an ERG target gene in human prostate tumors; Although induction of the tumor suppressive miR-200b subfamily by oncogenic ERG appears to be counterintuitive it is consistent with the observation that the vast majority of primary prostate cancers are slow-growing and indolent prostate cancer hsa-miR-429 ERG 2.84108892259147 3.88520896426515e-64 -1.79406293965654 1.24967833223395e-59 miRanda;miRNATAP -0.338103368763132 7.98461531705515e-59 NA NA NA hsa-miR-96-5p ERG 3.24596558166606 1.92296159041707e-98 -1.79406293965654 1.24967833223395e-59 TargetScan -0.3454337277711 4.85047488319939e-56 NA NA NA hsa-miR-378a-5p ERGIC1 -2.43173551693523 1.44932837789175e-68 0.646215620956665 8.40261132551627e-14 mirMAP -0.248513692106863 3.09801407119829e-39 NA NA NA hsa-miR-10b-5p ERI3 -2.10996264627796 7.36811595736367e-72 0.520697645234644 8.84269185921837e-17 miRNATAP -0.199092732956102 2.24756531173204e-34 NA NA NA hsa-miR-139-5p ERMN -3.25846663863766 2.62018989415003e-112 1.95764788735578 6.5519101657897e-24 miRanda -0.44504111992417 4.34377295161661e-29 NA NA NA hsa-miR-139-5p ERMP1 -3.25846663863766 2.62018989415003e-112 0.84384196405377 7.13232432971762e-16 miRanda -0.167321882165154 8.96871809043814e-15 NA NA NA hsa-miR-200c-3p ERRFI1 2.07038651806183 6.84613386286599e-51 -1.06077137481255 1.16711058066714e-20 miRNAWalker2_validate;miRTarBase;MirTarget -0.138484555642197 3.0695306989007e-07 NA NA NA hsa-miR-145-5p ESCO2 -2.62703571936687 7.64402900188551e-88 2.864165484727 1.91265101706756e-73 MirTarget -0.471415680439121 3.39517417077516e-34 NA NA NA hsa-miR-375 ESPNL 2.09893673049766 1.68351780396203e-16 -0.307478653096003 0.167455825518679 miRNAWalker2_validate -0.1042493257128 0.000379420025129374 NA NA NA hsa-miR-21-3p ESR1 2.17476065946878 5.15299442583591e-75 0.349232651607838 0.313942462521254 mirMAP -0.31824892123099 0.000480950639571142 19264808;25337203;21131358;25969534 miR-21 is higher in ER alpha positive than negative tumors but no one has examined how estradiol E2 regulates miR-21 in breast cancer cells; The E2-induced reduction in miR-21 was inhibited by 4-hydroxytamoxifen 4-OHT ICI 182 780 Faslodex and siRNA ER alpha indicating that the suppression is ER alpha-mediated; ER alpha and ER beta agonists PPT and DPN inhibited and 4-OHT increased miR-21 expression; These results are the first to demonstrate that E2 represses the expression of an oncogenic miRNA miR-21 by activating estrogen receptor in MCF-7 cells;Odds ratios ORs showed that miR-21 expression was closely associated with estrogen receptor ER progesterone receptor PR lymph node metastasis histological grade Her2/neu;Induction of miR 21 by retinoic acid in estrogen receptor positive breast carcinoma cells: biological correlates and molecular targets;Dehydroepiandrosterone Activation of G protein coupled Estrogen Receptor Rapidly Stimulates MicroRNA 21 Transcription in Human Hepatocellular Carcinoma Cells ;metastasis;; breast cancer;breast cancer;breast cancer;liver cancer hsa-miR-335-5p ESRP1 -2.61355235628987 2.6462884165886e-51 2.47414616820064 1.40364608684086e-49 miRNAWalker2_validate -0.291906597799396 1.81087424029741e-19 NA NA NA hsa-miR-182-5p ESYT1 2.36408084103818 2.60011457600281e-72 -0.943904276941184 1.86800476209515e-51 miRNATAP -0.143488161511342 2.27590038454088e-20 NA NA NA hsa-miR-96-5p ESYT1 3.24596558166606 1.92296159041707e-98 -0.943904276941184 1.86800476209515e-51 TargetScan;miRNATAP -0.142828349290701 3.035582013156e-29 NA NA NA hsa-miR-21-5p ESYT2 2.32007501846389 3.08394781855554e-137 -0.497972807025168 8.4627733747425e-17 miRNAWalker2_validate;MirTarget -0.174303504358701 4.93947213585361e-21 NA NA NA hsa-miR-378a-5p ETNK1 -2.43173551693523 1.44932837789175e-68 0.195329316720756 0.009730816642529 miRNAWalker2_validate -0.115934471906612 6.9781467392326e-12 NA NA NA hsa-miR-141-3p ETS1 2.99777540204168 1.26370498493024e-78 -0.979239394867202 3.4732433286646e-20 mirMAP -0.257236667059387 5.62368490791621e-37 NA NA NA hsa-miR-141-5p ETS1 2.38411349683216 4.56310582620282e-58 -0.979239394867202 3.4732433286646e-20 mirMAP -0.223127557221863 1.28606390051647e-22 NA NA NA hsa-miR-200a-3p ETS1 2.55218480823434 2.96135446816238e-51 -0.979239394867202 3.4732433286646e-20 mirMAP -0.226721918614687 1.27144828161341e-29 NA NA NA hsa-miR-200b-3p ETS1 2.11744072703209 1.66710572104191e-43 -0.979239394867202 3.4732433286646e-20 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.246496070854348 2.76376768290262e-28 NA NA NA hsa-miR-200c-3p ETS1 2.07038651806183 6.84613386286599e-51 -0.979239394867202 3.4732433286646e-20 MirTarget;miRNATAP -0.270324149960465 3.94762137659199e-28 NA NA NA hsa-miR-429 ETS1 2.84108892259147 3.88520896426515e-64 -0.979239394867202 3.4732433286646e-20 MirTarget;PITA;miRanda;miRNATAP -0.22461293513372 1.79940772021513e-29 NA NA NA hsa-miR-182-5p ETS2 2.36408084103818 2.60011457600281e-72 -1.31204961264283 1.86414767606317e-43 miRNATAP -0.27739516846608 1.05140895247181e-33 NA NA NA hsa-miR-200b-3p ETS2 2.11744072703209 1.66710572104191e-43 -1.31204961264283 1.86414767606317e-43 TargetScan -0.208203339435452 7.43124017252109e-24 NA NA NA hsa-miR-429 ETS2 2.84108892259147 3.88520896426515e-64 -1.31204961264283 1.86414767606317e-43 PITA;miRanda;miRNATAP -0.192318327414313 1.62138039028248e-25 NA NA NA hsa-miR-429 ETV1 2.84108892259147 3.88520896426515e-64 -1.26955346646186 2.18944858057772e-21 miRanda;miRNATAP -0.229521674715711 1.72786148709054e-19 NA NA NA hsa-miR-182-5p ETV3 2.36408084103818 2.60011457600281e-72 -0.69092229961494 2.93202890344859e-06 miRNAWalker2_validate -0.104232498181505 0.00323440176216426 NA NA NA hsa-miR-96-5p ETV3 3.24596558166606 1.92296159041707e-98 -0.69092229961494 2.93202890344859e-06 TargetScan -0.12307482607025 2.65256933746355e-05 NA NA NA hsa-miR-200b-3p ETV5 2.11744072703209 1.66710572104191e-43 -1.20431287113109 2.191175566387e-29 MirTarget;TargetScan -0.127469651008768 4.90629136908162e-08 27276064 This study aimed to investigate the effect of miR-200b on ERM expression in a breast cancer cell line and its influence on invasion and metastasis ability in vitro; RT-PCR was used to test miR-200b level while Western blot was selected to detect ERM protein expression; RESULTS RT-PCR revealed that miR-200b level in MDA-MB-231 was obviously lower than that in MCF-7 while Western blot analysis showed that ERM expression was significantly higher; MiR-200b inhibition by transfection in MCF-7 markedly decreased miR-200b level elevated ERM expression and enhanced cell migration and invasion; MiR-200b overexpression in MDA-MB-231 obviously increased miR-200b level reduced ERM expression and weakened cell migration and invasion; CONCLUSIONS MiR-200b participates in breast cancer cell migration and invasion through regulating ERM in MCF-7 and MDA-MB-231 metastasis;cell migration breast cancer hsa-miR-200c-3p ETV5 2.07038651806183 6.84613386286599e-51 -1.20431287113109 2.191175566387e-29 MirTarget;miRNATAP -0.134054777062746 1.86122451131347e-07 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration cell migration breast cancer hsa-miR-429 ETV5 2.84108892259147 3.88520896426515e-64 -1.20431287113109 2.191175566387e-29 MirTarget;PITA;miRanda;miRNATAP -0.127916245351139 8.032295367558e-10 NA NA NA hsa-miR-139-5p ETV7 -3.25846663863766 2.62018989415003e-112 1.75341598680344 1.10096514721554e-23 miRanda -0.365632198310762 3.16844551675351e-24 NA NA NA hsa-miR-486-5p ETV7 -3.87258704301474 1.22658629378451e-80 1.75341598680344 1.10096514721554e-23 miRanda -0.190245744706107 1.80507388599865e-12 NA NA NA hsa-miR-200b-3p EVI5 2.11744072703209 1.66710572104191e-43 -0.579984904122258 9.35428980902442e-20 MirTarget;TargetScan -0.122066262280476 1.74550784936078e-19 NA NA NA hsa-miR-200c-3p EVI5 2.07038651806183 6.84613386286599e-51 -0.579984904122258 9.35428980902442e-20 MirTarget;miRNATAP -0.131907912696313 7.68751581111602e-19 NA NA NA hsa-miR-429 EVI5 2.84108892259147 3.88520896426515e-64 -0.579984904122258 9.35428980902442e-20 MirTarget;PITA;miRanda;miRNATAP -0.110933130766587 3.70297544321251e-20 NA NA NA hsa-miR-96-5p EVI5 3.24596558166606 1.92296159041707e-98 -0.579984904122258 9.35428980902442e-20 miRNAWalker2_validate;TargetScan;miRNATAP -0.10156493857433 1.06869067479313e-15 NA NA NA hsa-miR-21-5p EXOC5 2.32007501846389 3.08394781855554e-137 -0.249132289068914 0.000144654237672916 miRNAWalker2_validate -0.136844263346474 1.3565987328826e-11 NA NA NA hsa-miR-200b-3p EXOC6B 2.11744072703209 1.66710572104191e-43 -1.11205921642431 1.51544495863844e-13 TargetScan -0.197968867079729 7.27583473908197e-10 NA NA NA hsa-miR-429 EYA1 2.84108892259147 3.88520896426515e-64 -1.78790496487044 2.84029254050585e-11 miRNATAP -0.292992883611132 1.01447156577304e-08 NA NA NA hsa-miR-429 EYA4 2.84108892259147 3.88520896426515e-64 -1.70735688835573 6.25677946773534e-11 miRNATAP -0.440577568934075 2.45248506790902e-19 NA NA NA hsa-miR-139-5p EZH2 -3.25846663863766 2.62018989415003e-112 2.33119052555976 1.35589352954227e-81 miRanda -0.462065646876897 2.82030567292304e-74 NA NA NA hsa-miR-145-5p F11R -2.62703571936687 7.64402900188551e-88 0.784299320718817 2.24787898258571e-28 miRNAWalker2_validate -0.117356053758665 3.24546654311589e-12 20818426;26374689 Our data identify JAM-A and fascin as novel targets of miR-145 firmly establishing a role for miR-145 in modulating breast cancer cell motility;MicroRNA screening predicted that microRNA-145 miR-145 would bind to JAM-A; Using patient-derived glioblastoma CSCs we confirmed that JAM-A is suppressed by miR-145 motility; breast cancer;glioblastoma hsa-miR-182-5p F13A1 2.36408084103818 2.60011457600281e-72 -1.40560514259093 1.32491699599028e-13 miRNATAP -0.371805238771329 1.76116860741431e-16 NA NA NA hsa-miR-96-5p F13A1 3.24596558166606 1.92296159041707e-98 -1.40560514259093 1.32491699599028e-13 TargetScan;miRNATAP -0.403199330562131 8.42481497881882e-28 NA NA NA hsa-miR-21-3p F3 2.17476065946878 5.15299442583591e-75 -2.18337486686632 5.89270776390065e-40 MirTarget -0.450747004889315 3.37604723019804e-24 NA NA NA hsa-miR-375 F3 2.09893673049766 1.68351780396203e-16 -2.18337486686632 5.89270776390065e-40 miRNAWalker2_validate -0.131770594037874 6.5214728314235e-09 NA NA NA hsa-miR-429 F8 2.84108892259147 3.88520896426515e-64 -1.83837743951794 1.53567335762669e-73 miRNATAP -0.254910867431614 1.08490008926765e-36 NA NA NA hsa-miR-335-5p FAAH2 -2.61355235628987 2.6462884165886e-51 1.30806690005785 1.19142414323445e-19 miRNAWalker2_validate -0.152430868416205 2.17234564317113e-08 NA NA NA hsa-miR-429 FABP5 2.84108892259147 3.88520896426515e-64 -1.36683244095868 1.44353669986839e-14 miRanda -0.17099318890093 5.09548156393445e-07 NA NA NA hsa-miR-335-5p FABP6 -2.61355235628987 2.6462884165886e-51 2.50439462554375 7.66589896961204e-14 miRNAWalker2_validate -0.3040805441599 1.35692812969832e-06 NA NA NA hsa-miR-96-5p FADS1 3.24596558166606 1.92296159041707e-98 -0.100594032532292 0.510994207192077 MirTarget -0.101387919885184 0.000788905250472376 NA NA NA hsa-miR-335-5p FADS2 -2.61355235628987 2.6462884165886e-51 1.13203437938517 1.75285069585599e-07 miRNAWalker2_validate -0.213177012272824 1.23936137436041e-07 NA NA NA hsa-miR-96-5p FADS3 3.24596558166606 1.92296159041707e-98 -1.18746136910571 7.46380980410048e-29 TargetScan -0.172232301889874 9.84077194427845e-16 NA NA NA hsa-miR-141-5p FAHD2A 2.38411349683216 4.56310582620282e-58 -0.424868786466341 2.89950832668615e-07 mirMAP -0.107788431067412 1.22806247696083e-09 NA NA NA hsa-miR-141-5p FAIM2 2.38411349683216 4.56310582620282e-58 -0.153328534808712 0.529442614210649 mirMAP -0.120346471873251 0.0215837336999776 NA NA NA hsa-miR-335-5p FAM102A -2.61355235628987 2.6462884165886e-51 1.23639689570928 1.94284110814203e-47 miRNAWalker2_validate;mirMAP -0.129309533882243 6.17194547362783e-15 NA NA NA hsa-miR-182-5p FAM107A 2.36408084103818 2.60011457600281e-72 -3.7437044389083 2.37244574734405e-64 MirTarget -0.733934538434536 1.34922904872776e-41 NA NA NA hsa-miR-21-5p FAM107B 2.32007501846389 3.08394781855554e-137 -0.213307470420947 0.025240785122864 miRNATAP -0.110814609413332 0.000186371814630281 NA NA NA hsa-miR-10b-5p FAM109A -2.10996264627796 7.36811595736367e-72 0.537094497092194 9.74350190924683e-12 mirMAP -0.128715129388055 1.01721158532804e-09 NA NA NA hsa-miR-378a-5p FAM109B -2.43173551693523 1.44932837789175e-68 0.670326508667007 3.61936000728905e-17 MirTarget -0.105568372660187 6.83240591898211e-09 NA NA NA hsa-miR-145-5p FAM110C -2.62703571936687 7.64402900188551e-88 1.08612311763296 6.36539879665119e-08 MirTarget -0.325079308508332 2.6088577890185e-12 NA NA NA hsa-miR-335-5p FAM110C -2.61355235628987 2.6462884165886e-51 1.08612311763296 6.36539879665119e-08 miRNAWalker2_validate -0.191183949512006 3.19603881897923e-07 NA NA NA hsa-miR-511-5p FAM111B -2.27545475897362 3.84085514050558e-36 2.84130742486352 7.94203349254186e-61 MirTarget -0.158167759845132 2.90887067107838e-06 NA NA NA hsa-miR-182-5p FAM124A 2.36408084103818 2.60011457600281e-72 -1.41450535767103 8.84520765423519e-28 mirMAP -0.290782577262298 1.1082489409464e-20 NA NA NA hsa-miR-200b-3p FAM126A 2.11744072703209 1.66710572104191e-43 -2.26267854810928 3.52419275607188e-65 TargetScan -0.338188470641347 1.86006972579887e-30 NA NA NA hsa-miR-21-5p FAM126B 2.32007501846389 3.08394781855554e-137 -0.47592775622376 8.08751743843368e-12 miRNAWalker2_validate -0.216279509860791 3.86543497039112e-24 NA NA NA hsa-miR-429 FAM129A 2.84108892259147 3.88520896426515e-64 -1.5090398707494 8.40707116225318e-22 miRanda -0.169335683347532 2.46092835652249e-08 NA NA NA hsa-miR-335-5p FAM131C -2.61355235628987 2.6462884165886e-51 0.0374202900839968 0.878593821078206 miRNAWalker2_validate -0.132539881925657 0.0035606112185824 NA NA NA hsa-miR-141-3p FAM133A 2.99777540204168 1.26370498493024e-78 -0.462614622871152 0.0357864947582745 mirMAP -0.247180193144815 6.20999632472482e-09 NA NA NA hsa-miR-200a-3p FAM133A 2.55218480823434 2.96135446816238e-51 -0.462614622871152 0.0357864947582745 mirMAP -0.208831642418516 6.0061359381919e-07 NA NA NA hsa-miR-429 FAM133A 2.84108892259147 3.88520896426515e-64 -0.462614622871152 0.0357864947582745 miRanda -0.158533852198 0.000142847559581523 NA NA NA hsa-miR-141-5p FAM135A 2.38411349683216 4.56310582620282e-58 -1.25723792576387 7.59505292047769e-25 MirTarget;miRNATAP -0.157882043477631 3.91542509058391e-09 NA NA NA hsa-miR-21-3p FAM135A 2.17476065946878 5.15299442583591e-75 -1.25723792576387 7.59505292047769e-25 MirTarget -0.140023519137565 2.24251621646725e-05 NA NA NA hsa-miR-375 FAM135A 2.09893673049766 1.68351780396203e-16 -1.25723792576387 7.59505292047769e-25 miRanda -0.138175264028737 2.19193707391442e-17 NA NA NA hsa-miR-429 FAM135A 2.84108892259147 3.88520896426515e-64 -1.25723792576387 7.59505292047769e-25 miRanda;miRNATAP -0.173323375226252 1.68983352883916e-13 NA NA NA hsa-miR-224-5p FAM135B -2.22249420723892 1.07787949391113e-18 0.297929137431374 0.2926521551134 MirTarget -0.30557314375627 1.42552693168215e-16 NA NA NA hsa-miR-429 FAM13A 2.84108892259147 3.88520896426515e-64 -2.57201735378438 3.81293606408784e-108 miRanda;miRNATAP -0.311050493324474 5.11907978826639e-38 NA NA NA hsa-miR-96-5p FAM13A 3.24596558166606 1.92296159041707e-98 -2.57201735378438 3.81293606408784e-108 TargetScan -0.360715286475856 1.175451270497e-47 NA NA NA hsa-miR-429 FAM13C 2.84108892259147 3.88520896426515e-64 -2.74283933204044 6.93026347155093e-64 miRanda -0.448343484188418 8.2391506608088e-46 NA NA NA hsa-miR-141-3p FAM150B 2.99777540204168 1.26370498493024e-78 -4.06702877061331 5.65524776776469e-43 MirTarget -0.454365833420014 3.14778667897943e-14 NA NA NA hsa-miR-200a-3p FAM150B 2.55218480823434 2.96135446816238e-51 -4.06702877061331 5.65524776776469e-43 MirTarget -0.335341925606233 1.43910542042615e-08 NA NA NA hsa-miR-429 FAM150B 2.84108892259147 3.88520896426515e-64 -4.06702877061331 5.65524776776469e-43 miRanda;miRNATAP -0.369732751533434 2.84367620994586e-10 NA NA NA hsa-miR-429 FAM155A 2.84108892259147 3.88520896426515e-64 0.47394284157842 0.0167065845084408 MirTarget;miRanda -0.126832726385145 0.000721264075380171 NA NA NA hsa-miR-486-5p FAM159A -3.87258704301474 1.22658629378451e-80 1.16497163187849 1.23384979961282e-14 miRanda -0.139376958159007 1.69959472448339e-09 NA NA NA hsa-miR-141-3p FAM160B1 2.99777540204168 1.26370498493024e-78 -0.617695385113071 7.35235824201269e-22 TargetScan -0.12250199614386 9.15173520732588e-23 NA NA NA hsa-miR-429 FAM160B1 2.84108892259147 3.88520896426515e-64 -0.617695385113071 7.35235824201269e-22 miRanda -0.120827088703847 2.56548325566112e-23 NA NA NA hsa-miR-139-5p FAM162A -3.25846663863766 2.62018989415003e-112 0.73375094459618 4.43695000208396e-17 miRanda -0.161231256593843 2.48757746771365e-19 NA NA NA hsa-miR-141-3p FAM168A 2.99777540204168 1.26370498493024e-78 -0.595647286022841 1.59492655064768e-06 TargetScan -0.102631517583844 2.21136567234435e-05 NA NA NA hsa-miR-96-5p FAM168A 3.24596558166606 1.92296159041707e-98 -0.595647286022841 1.59492655064768e-06 TargetScan -0.126036127158764 2.82324336751828e-07 NA NA NA hsa-miR-21-3p FAM168B 2.17476065946878 5.15299442583591e-75 -0.644497827993824 1.36529150838078e-27 mirMAP -0.127862704671699 6.18350809824622e-16 NA NA NA hsa-miR-182-5p FAM171A1 2.36408084103818 2.60011457600281e-72 -1.36306581619799 6.83768823453717e-19 miRNATAP -0.383894265909938 3.7084011596083e-26 NA NA NA hsa-miR-429 FAM171A1 2.84108892259147 3.88520896426515e-64 -1.36306581619799 6.83768823453717e-19 miRanda -0.152564892506837 2.48100868398557e-07 NA NA NA hsa-miR-96-5p FAM171A1 3.24596558166606 1.92296159041707e-98 -1.36306581619799 6.83768823453717e-19 miRNAWalker2_validate;TargetScan;miRNATAP -0.274354724006358 1.68034096532894e-19 NA NA NA hsa-miR-10b-5p FAM171A2 -2.10996264627796 7.36811595736367e-72 1.13764551378586 4.34605218636136e-12 mirMAP -0.44184780480595 1.21701399098054e-24 NA NA NA hsa-miR-429 FAM171B 2.84108892259147 3.88520896426515e-64 -0.770097002812701 7.43312077879055e-08 miRanda -0.16942785580856 3.85336438296105e-10 NA NA NA hsa-miR-145-5p FAM174B -2.62703571936687 7.64402900188551e-88 0.938847978718496 2.09447872603151e-12 MirTarget -0.172552724689468 3.33903560316177e-08 NA NA NA hsa-miR-429 FAM175A 2.84108892259147 3.88520896426515e-64 -0.764845309593068 3.79880143480269e-26 miRanda -0.101596480125265 3.03711611193169e-13 NA NA NA hsa-miR-224-5p FAM177B -2.22249420723892 1.07787949391113e-18 0.341458252324422 0.187611697330857 MirTarget -0.147577787915589 1.74114361496924e-05 NA NA NA hsa-miR-375 FAM180A 2.09893673049766 1.68351780396203e-16 -1.54070778927332 1.44433264843771e-19 miRanda -0.1340937903857 4.0855369206658e-09 NA NA NA hsa-miR-183-5p FAM189A1 2.95681814393872 1.09965777344285e-92 0.339750291294292 0.199307555843452 mirMAP -0.122692854640588 0.0279680570210586 NA NA NA hsa-miR-335-5p FAM189A1 -2.61355235628987 2.6462884165886e-51 0.339750291294292 0.199307555843452 miRNAWalker2_validate;mirMAP -0.136168219573309 0.0056188985551788 NA NA NA hsa-miR-335-5p FAM196A -2.61355235628987 2.6462884165886e-51 1.98296570560131 3.09651461409495e-10 miRNAWalker2_validate -0.124525332564946 0.0355616594249266 NA NA NA hsa-miR-452-5p FAM196A -2.48486455572568 1.24430987974325e-33 1.98296570560131 3.09651461409495e-10 mirMAP -0.61021539959501 6.07189040503729e-36 NA NA NA hsa-miR-429 FAM198B 2.84108892259147 3.88520896426515e-64 -0.655937587733984 3.12445009730366e-05 miRanda -0.15976137783417 8.09524921809876e-08 NA NA NA hsa-miR-200b-3p FAM19A2 2.11744072703209 1.66710572104191e-43 -1.03128328074293 5.23081782144387e-12 MirTarget -0.114337318836679 0.000364810509970369 NA NA NA hsa-miR-200c-3p FAM19A2 2.07038651806183 6.84613386286599e-51 -1.03128328074293 5.23081782144387e-12 MirTarget -0.117472569211795 0.000872791003779172 NA NA NA hsa-miR-429 FAM19A2 2.84108892259147 3.88520896426515e-64 -1.03128328074293 5.23081782144387e-12 MirTarget;miRanda -0.125059711421347 1.21918655839337e-05 NA NA NA hsa-miR-139-5p FAM19A5 -3.25846663863766 2.62018989415003e-112 0.691134405778381 0.00015056871256656 miRanda -0.156744101398351 3.00898336792564e-05 NA NA NA hsa-miR-21-5p FAM20B 2.32007501846389 3.08394781855554e-137 0.0762927451977209 0.249948625868536 miRNAWalker2_validate -0.103484094720083 4.53605224810891e-07 NA NA NA hsa-miR-141-3p FAM20C 2.99777540204168 1.26370498493024e-78 -0.239487690566357 0.0313275504069408 MirTarget -0.140090967600342 5.94062773113374e-11 NA NA NA hsa-miR-141-3p FAM26E 2.99777540204168 1.26370498493024e-78 -0.82275122127776 5.46439917028421e-11 mirMAP -0.341083058666723 8.43237613195517e-49 NA NA NA hsa-miR-182-5p FAM26E 2.36408084103818 2.60011457600281e-72 -0.82275122127776 5.46439917028421e-11 mirMAP -0.238388429365605 1.10929823768941e-15 NA NA NA hsa-miR-200a-3p FAM26E 2.55218480823434 2.96135446816238e-51 -0.82275122127776 5.46439917028421e-11 mirMAP -0.298564995364986 3.52123043506639e-38 NA NA NA hsa-miR-200a-5p FAM26E 2.58844508672328 1.79650654234569e-56 -0.82275122127776 5.46439917028421e-11 mirMAP -0.227767827176135 5.01259703742492e-21 NA NA NA hsa-miR-200b-3p FAM26E 2.11744072703209 1.66710572104191e-43 -0.82275122127776 5.46439917028421e-11 mirMAP -0.336697599830851 2.58381835984909e-39 NA NA NA hsa-miR-429 FAM26E 2.84108892259147 3.88520896426515e-64 -0.82275122127776 5.46439917028421e-11 mirMAP -0.276333083061097 5.99986816945457e-33 NA NA NA hsa-miR-96-5p FAM43A 3.24596558166606 1.92296159041707e-98 -1.12449435465106 2.78306489092465e-29 TargetScan -0.251537607728214 9.56441572994898e-38 NA NA NA hsa-miR-183-5p FAM46A 2.95681814393872 1.09965777344285e-92 -0.55729510774815 6.61021166956354e-07 miRNATAP -0.113289998526767 1.67525937134565e-06 NA NA NA hsa-miR-21-5p FAM46A 2.32007501846389 3.08394781855554e-137 -0.55729510774815 6.61021166956354e-07 miRNAWalker2_validate;miRNATAP -0.213449740798425 8.95844182792362e-10 NA NA NA hsa-miR-224-5p FAM46C -2.22249420723892 1.07787949391113e-18 0.238475127523464 0.105075932361393 MirTarget -0.12281842246645 2.34384671714204e-10 NA NA NA hsa-miR-145-5p FAM49B -2.62703571936687 7.64402900188551e-88 0.716330772829237 1.654396801579e-19 MirTarget -0.109383628006538 4.75735691217779e-09 NA NA NA hsa-miR-335-5p FAM57B -2.61355235628987 2.6462884165886e-51 2.91127175275632 1.72905948911223e-29 mirMAP -0.328097550700556 2.61333507373722e-11 NA NA NA hsa-miR-200b-3p FAM63B 2.11744072703209 1.66710572104191e-43 -1.04324614957652 4.45317569057325e-13 TargetScan -0.173181188519981 1.85714062431379e-08 NA NA NA hsa-miR-21-3p FAM63B 2.17476065946878 5.15299442583591e-75 -1.04324614957652 4.45317569057325e-13 mirMAP -0.158700762257005 3.54096024049752e-05 NA NA NA hsa-miR-21-5p FAM63B 2.32007501846389 3.08394781855554e-137 -1.04324614957652 4.45317569057325e-13 miRNATAP -0.349396451913809 6.76940380623322e-15 NA NA NA hsa-miR-429 FAM65C 2.84108892259147 3.88520896426515e-64 -0.751082303808715 2.9957496829705e-05 miRanda -0.124551117438191 0.000268413342861769 NA NA NA hsa-miR-511-5p FAM71D -2.27545475897362 3.84085514050558e-36 0.921062047700975 6.52949885895472e-31 MirTarget -0.107157169279495 5.4856622789252e-13 NA NA NA hsa-miR-182-5p FAM78A 2.36408084103818 2.60011457600281e-72 0.309076908663902 0.00299576168516835 MirTarget;miRNATAP -0.111736500694042 6.34566834814755e-06 NA NA NA hsa-miR-486-5p FAM81B -3.87258704301474 1.22658629378451e-80 0.436943721501207 0.148078993855461 miRanda -0.159199717255202 0.000514938605313803 NA NA NA hsa-miR-139-5p FAM83D -3.25846663863766 2.62018989415003e-112 3.32613111450604 2.65378571467021e-69 miRanda -0.676400522269607 3.96527642537044e-67 NA NA NA hsa-miR-486-5p FAM83D -3.87258704301474 1.22658629378451e-80 3.32613111450604 2.65378571467021e-69 miRanda -0.332812670284172 5.42451688307836e-28 NA NA NA hsa-miR-139-5p FAM84B -3.25846663863766 2.62018989415003e-112 0.617555027920064 1.07556488149827e-08 PITA;miRanda -0.158332098945004 8.44893644774998e-13 NA NA NA hsa-miR-375 FAM89A 2.09893673049766 1.68351780396203e-16 -2.43024803625542 6.72302890829116e-59 miRNAWalker2_validate -0.27939804445549 2.30522309416435e-43 NA NA NA hsa-miR-10b-5p FAM91A1 -2.10996264627796 7.36811595736367e-72 0.515410158144582 1.30483391425908e-10 MirTarget -0.130070114753395 1.22901297247732e-09 NA NA NA hsa-miR-139-5p FAM91A1 -3.25846663863766 2.62018989415003e-112 0.515410158144582 1.30483391425908e-10 MirTarget;miRanda -0.129177361263588 3.55282465514663e-15 NA NA NA hsa-miR-139-5p FANCA -3.25846663863766 2.62018989415003e-112 2.19582170071971 1.17574258993425e-49 miRanda -0.446246592080986 3.89702709793893e-48 NA NA NA hsa-miR-139-5p FANCB -3.25846663863766 2.62018989415003e-112 0.893018597503096 3.11882108372804e-13 miRanda -0.2714642215927 5.75437731001288e-28 NA NA NA hsa-miR-378a-5p FANCF -2.43173551693523 1.44932837789175e-68 0.989887565664683 5.76000510699438e-45 MirTarget -0.235924344586859 2.50898032735394e-50 NA NA NA hsa-miR-183-5p FAT1 2.95681814393872 1.09965777344285e-92 -1.48013040929277 2.24548360990436e-21 MirTarget -0.265188212243302 1.26235641515623e-15 NA NA NA hsa-miR-183-5p FAT2 2.95681814393872 1.09965777344285e-92 -3.5119162739873 6.50165313187044e-33 miRNAWalker2_validate -0.654814525656326 1.40866735303558e-25 NA NA NA hsa-miR-141-3p FAT3 2.99777540204168 1.26370498493024e-78 -1.39927804148844 8.16110526253237e-11 MirTarget;miRNATAP -0.498551032777222 1.30921453727467e-34 NA NA NA hsa-miR-182-5p FAT3 2.36408084103818 2.60011457600281e-72 -1.39927804148844 8.16110526253237e-11 mirMAP -0.354106045935693 5.18803077208505e-12 NA NA NA hsa-miR-183-5p FAT3 2.95681814393872 1.09965777344285e-92 -1.39927804148844 8.16110526253237e-11 miRNATAP -0.368037124861005 3.51817134191462e-16 NA NA NA hsa-miR-200a-3p FAT3 2.55218480823434 2.96135446816238e-51 -1.39927804148844 8.16110526253237e-11 MirTarget;miRNATAP -0.456732428853608 4.74432434641576e-30 NA NA NA hsa-miR-200b-3p FAT3 2.11744072703209 1.66710572104191e-43 -1.39927804148844 8.16110526253237e-11 MirTarget;TargetScan -0.47348490049486 4.57929919214598e-26 NA NA NA hsa-miR-200c-3p FAT3 2.07038651806183 6.84613386286599e-51 -1.39927804148844 8.16110526253237e-11 MirTarget;miRNATAP -0.550888508321856 3.2823164589328e-29 NA NA NA hsa-miR-21-3p FAT3 2.17476065946878 5.15299442583591e-75 -1.39927804148844 8.16110526253237e-11 MirTarget -0.113367551787997 0.0483725727693704 NA NA NA hsa-miR-429 FAT3 2.84108892259147 3.88520896426515e-64 -1.39927804148844 8.16110526253237e-11 MirTarget;PITA;miRanda;miRNATAP -0.412049775205869 9.30119372102129e-25 NA NA NA hsa-miR-96-5p FAT3 3.24596558166606 1.92296159041707e-98 -1.39927804148844 8.16110526253237e-11 TargetScan -0.422748913863575 6.34581556851004e-24 NA NA NA hsa-miR-429 FAT4 2.84108892259147 3.88520896426515e-64 -2.33360300758631 3.89695808711231e-45 miRanda;miRNATAP -0.456426166409735 2.92966325511876e-48 NA NA NA hsa-miR-10b-5p FBF1 -2.10996264627796 7.36811595736367e-72 0.681020445483 2.55821154950566e-12 MirTarget -0.215079263792513 7.47397370737965e-17 NA NA NA hsa-miR-429 FBLN1 2.84108892259147 3.88520896426515e-64 -0.991321928153263 4.17334822650844e-13 miRanda -0.263785640996207 4.95897402728283e-25 NA NA NA hsa-miR-200c-3p FBLN5 2.07038651806183 6.84613386286599e-51 -2.08643289665163 1.31128583188143e-54 miRNAWalker2_validate;miRTarBase -0.431582532539337 7.04635991309229e-42 NA NA NA hsa-miR-429 FBLN5 2.84108892259147 3.88520896426515e-64 -2.08643289665163 1.31128583188143e-54 miRanda;miRNATAP -0.332874799545084 1.53710744952646e-37 NA NA NA hsa-miR-182-5p FBN1 2.36408084103818 2.60011457600281e-72 -0.638584226140373 7.0335453791039e-05 miRNATAP -0.227607365082274 2.34110453365045e-09 NA NA NA hsa-miR-429 FBN1 2.84108892259147 3.88520896426515e-64 -0.638584226140373 7.0335453791039e-05 miRNATAP -0.312500240287817 5.3468432970057e-26 NA NA NA hsa-miR-139-5p FBN2 -3.25846663863766 2.62018989415003e-112 2.86126193436058 1.17556247261121e-35 MirTarget;PITA;miRanda;miRNATAP -0.563936158585124 1.80898032753337e-32 NA NA NA hsa-miR-335-5p FBN2 -2.61355235628987 2.6462884165886e-51 2.86126193436058 1.17556247261121e-35 miRNAWalker2_validate -0.33833937437666 1.32186374111528e-14 NA NA NA hsa-miR-139-5p FBXL16 -3.25846663863766 2.62018989415003e-112 1.94914353883699 1.22752518019124e-19 MirTarget;PITA;miRanda;miRNATAP -0.243272654785412 6.5282783788188e-08 NA NA NA hsa-miR-21-5p FBXL17 2.32007501846389 3.08394781855554e-137 -0.668522152180613 6.29359999455586e-17 miRNAWalker2_validate;miRNATAP -0.286204323216819 1.20316727680549e-31 NA NA NA hsa-miR-429 FBXL17 2.84108892259147 3.88520896426515e-64 -0.668522152180613 6.29359999455586e-17 miRanda;miRNATAP -0.11162969235689 2.24795858461178e-13 NA NA NA hsa-miR-144-5p FBXL19 -2.75914786146772 1.55794225315972e-50 1.49662531245563 1.13477816961475e-61 miRNATAP -0.134422071731586 8.96912255755874e-16 NA NA NA hsa-miR-429 FBXL3 2.84108892259147 3.88520896426515e-64 -0.784319150959447 5.41734962361963e-23 miRanda -0.138233106903188 5.77316554339684e-20 NA NA NA hsa-miR-335-5p FBXL8 -2.61355235628987 2.6462884165886e-51 0.666546045226743 1.89775388222703e-06 miRNAWalker2_validate -0.15623629807224 1.66972412895486e-09 NA NA NA hsa-miR-21-5p FBXO11 2.32007501846389 3.08394781855554e-137 -0.32822128474722 1.20107116640815e-11 miRNAWalker2_validate;miRNATAP -0.150419868286549 2.90606997992055e-24 NA NA NA hsa-miR-96-5p FBXO27 3.24596558166606 1.92296159041707e-98 -0.917677434303935 9.8200285865995e-09 TargetScan -0.138590999562643 1.32717860884988e-05 NA NA NA hsa-miR-21-5p FBXO3 2.32007501846389 3.08394781855554e-137 -0.335355498401874 1.50603301258767e-07 miRNAWalker2_validate -0.162176075054113 1.56719015700219e-16 NA NA NA hsa-miR-182-5p FBXO32 2.36408084103818 2.60011457600281e-72 -0.728200631321172 9.08526238939554e-09 mirMAP -0.242266009434183 5.92809880456066e-16 NA NA NA hsa-miR-96-5p FBXO32 3.24596558166606 1.92296159041707e-98 -0.728200631321172 9.08526238939554e-09 TargetScan;mirMAP -0.177259960328534 1.21781722947227e-12 NA NA NA hsa-miR-486-5p FBXO46 -3.87258704301474 1.22658629378451e-80 0.956685970981098 1.08201079244471e-38 miRanda -0.108654752094407 1.95895682230696e-21 NA NA NA hsa-miR-106b-5p FBXW11 1.22477789913175 2.31787213143326e-32 -0.316312720644922 6.71697037089303e-08 miRNATAP -0.176360910717368 7.82361659308432e-22 NA NA NA hsa-miR-20a-5p FBXW11 0.44979911120222 0.000602386964327228 -0.316312720644922 6.71697037089303e-08 miRNATAP -0.144291334426437 6.70457379214045e-22 NA NA NA hsa-miR-340-5p FBXW11 1.0857159627596 4.94471062546756e-24 -0.316312720644922 6.71697037089303e-08 mirMAP -0.119257544627908 4.94445433521861e-11 NA NA NA hsa-miR-374a-5p FBXW11 -0.239709888246804 0.00309819667153627 -0.316312720644922 6.71697037089303e-08 mirMAP -0.175519580181888 1.34257782586297e-12 NA NA NA hsa-miR-374b-5p FBXW11 -0.466781429946153 1.17238311619116e-08 -0.316312720644922 6.71697037089303e-08 mirMAP -0.115315723202322 2.61335640229646e-06 NA NA NA hsa-miR-93-5p FBXW11 1.01788600209314 1.24312921618126e-21 -0.316312720644922 6.71697037089303e-08 miRNATAP -0.149796521194947 1.90586895576967e-16 NA NA NA hsa-miR-200b-3p FBXW7 2.11744072703209 1.66710572104191e-43 -1.04726780821632 1.02766405186634e-61 TargetScan -0.115533487792978 4.42176858537462e-16 NA NA NA hsa-miR-429 FBXW7 2.84108892259147 3.88520896426515e-64 -1.04726780821632 1.02766405186634e-61 PITA;miRanda -0.107742468026765 1.85983878222926e-17 NA NA NA hsa-miR-200c-3p FCHO2 2.07038651806183 6.84613386286599e-51 -0.606061420659775 1.08535609457921e-15 mirMAP -0.101098280823348 1.35123496996583e-08 NA NA NA hsa-miR-21-5p FCHO2 2.32007501846389 3.08394781855554e-137 -0.606061420659775 1.08535609457921e-15 miRNATAP -0.207844035881331 8.24692821106582e-19 NA NA NA hsa-miR-429 FCHO2 2.84108892259147 3.88520896426515e-64 -0.606061420659775 1.08535609457921e-15 mirMAP -0.104433395990616 3.63709201004997e-13 NA NA NA hsa-miR-375 FCRL3 2.09893673049766 1.68351780396203e-16 0.799879914744875 0.003851675610683 miRanda -0.150043476300105 3.89290902342124e-05 NA NA NA hsa-miR-141-3p FER 2.99777540204168 1.26370498493024e-78 -1.39984522785187 1.37974026576335e-30 mirMAP -0.260716767655561 5.65369583972009e-28 NA NA NA hsa-miR-182-5p FER 2.36408084103818 2.60011457600281e-72 -1.39984522785187 1.37974026576335e-30 mirMAP -0.254596044153547 6.75602013944645e-18 NA NA NA hsa-miR-200a-3p FER 2.55218480823434 2.96135446816238e-51 -1.39984522785187 1.37974026576335e-30 mirMAP -0.237419580733984 4.27184059308637e-24 NA NA NA hsa-miR-429 FER 2.84108892259147 3.88520896426515e-64 -1.39984522785187 1.37974026576335e-30 miRanda -0.244907336349036 5.50096040267237e-26 NA NA NA hsa-miR-429 FER1L5 2.84108892259147 3.88520896426515e-64 -1.49525147289193 7.39872679440538e-10 miRanda -0.170370177014361 0.000241401985069843 NA NA NA hsa-miR-200b-3p FERMT2 2.11744072703209 1.66710572104191e-43 -1.85633940208907 3.36734523172304e-65 TargetScan -0.385571245951135 5.50529908068042e-62 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-21-5p FERMT2 2.32007501846389 3.08394781855554e-137 -1.85633940208907 3.36734523172304e-65 miRNAWalker2_validate -0.395121625605477 1.35565362055128e-28 NA NA NA hsa-miR-429 FERMT2 2.84108892259147 3.88520896426515e-64 -1.85633940208907 3.36734523172304e-65 miRanda;miRNATAP -0.347643412445339 2.23250122715493e-63 NA NA NA hsa-miR-200b-3p FEZ2 2.11744072703209 1.66710572104191e-43 -0.850269532845046 1.36966796237694e-51 TargetScan -0.19460972551043 2.10235060115672e-61 NA NA NA hsa-miR-429 FEZ2 2.84108892259147 3.88520896426515e-64 -0.850269532845046 1.36966796237694e-51 PITA;miRanda;miRNATAP -0.165376723703366 7.02799599208053e-55 NA NA NA hsa-miR-335-5p FGD3 -2.61355235628987 2.6462884165886e-51 1.63391348631557 4.0615298015993e-19 miRNAWalker2_validate -0.162738377543723 2.56288704785833e-06 NA NA NA hsa-miR-182-5p FGD4 2.36408084103818 2.60011457600281e-72 -1.49828428011676 4.81174832826187e-54 MirTarget -0.190192414299703 4.92670208526891e-15 NA NA NA hsa-miR-200a-5p FGD4 2.58844508672328 1.79650654234569e-56 -1.49828428011676 4.81174832826187e-54 mirMAP -0.145059234306302 3.67010999150497e-13 NA NA NA hsa-miR-21-5p FGD4 2.32007501846389 3.08394781855554e-137 -1.49828428011676 4.81174832826187e-54 MirTarget -0.45517552665339 5.75049173554973e-51 NA NA NA hsa-miR-429 FGD4 2.84108892259147 3.88520896426515e-64 -1.49828428011676 4.81174832826187e-54 miRanda;miRNATAP -0.190997282171982 1.48246285721846e-23 NA NA NA hsa-miR-96-5p FGD4 3.24596558166606 1.92296159041707e-98 -1.49828428011676 4.81174832826187e-54 TargetScan -0.202878193578776 2.1957682795219e-24 NA NA NA hsa-miR-486-5p FGD6 -3.87258704301474 1.22658629378451e-80 0.48802580354965 2.76984999667147e-05 miRanda -0.103429413484549 4.35390980183101e-09 NA NA NA hsa-miR-21-5p FGF1 2.32007501846389 3.08394781855554e-137 -2.3363200609921 2.42261900591497e-58 MirTarget -0.371477796734357 9.2806521720649e-15 NA NA NA hsa-miR-429 FGF1 2.84108892259147 3.88520896426515e-64 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.325212393355327 4.60753740095485e-30 NA NA NA hsa-miR-200b-3p FGF10 2.11744072703209 1.66710572104191e-43 -3.32771291998068 2.19492306477012e-23 TargetScan -0.477562798964516 3.55044319062017e-11 NA NA NA hsa-miR-200b-3p FGF12 2.11744072703209 1.66710572104191e-43 -0.643446523257955 0.000892623765099953 TargetScan -0.165329959072644 5.71604844896826e-05 NA NA NA hsa-miR-429 FGF12 2.84108892259147 3.88520896426515e-64 -0.643446523257955 0.000892623765099953 miRNATAP -0.122602237479307 0.000847169715536382 NA NA NA hsa-miR-141-3p FGF13 2.99777540204168 1.26370498493024e-78 -0.873614793965912 3.10323995957847e-07 TargetScan -0.151235108253828 5.55097538879746e-06 NA NA NA hsa-miR-200a-5p FGF13 2.58844508672328 1.79650654234569e-56 -0.873614793965912 3.10323995957847e-07 MirTarget;miRNATAP -0.144569347995968 1.56153098119586e-05 NA NA NA hsa-miR-96-5p FGF14 3.24596558166606 1.92296159041707e-98 -0.743601748556524 2.04913944157729e-05 TargetScan -0.186868577790991 5.83679167463715e-08 NA NA NA hsa-miR-200b-3p FGF18 2.11744072703209 1.66710572104191e-43 0.356025539172725 0.0347430848266563 TargetScan -0.225608292610904 1.9483944408265e-10 NA NA NA hsa-miR-200c-3p FGF18 2.07038651806183 6.84613386286599e-51 0.356025539172725 0.0347430848266563 miRNATAP -0.297918294437242 1.5236208240269e-14 NA NA NA hsa-miR-429 FGF18 2.84108892259147 3.88520896426515e-64 0.356025539172725 0.0347430848266563 miRNATAP -0.192282799804847 1.28904804259296e-09 NA NA NA hsa-miR-200b-3p FGF2 2.11744072703209 1.66710572104191e-43 -3.62110997961421 1.11252046868458e-69 mirMAP -0.474105291344653 1.09246839719196e-24 NA NA NA hsa-miR-200c-3p FGF2 2.07038651806183 6.84613386286599e-51 -3.62110997961421 1.11252046868458e-69 mirMAP -0.615252170517975 1.40903756446366e-34 NA NA NA hsa-miR-21-3p FGF2 2.17476065946878 5.15299442583591e-75 -3.62110997961421 1.11252046868458e-69 mirMAP -0.712905950790447 1.55737305852276e-36 NA NA NA hsa-miR-21-5p FGF2 2.32007501846389 3.08394781855554e-137 -3.62110997961421 1.11252046868458e-69 mirMAP -1.0007316696677 9.45001605861665e-53 NA NA NA hsa-miR-429 FGF2 2.84108892259147 3.88520896426515e-64 -3.62110997961421 1.11252046868458e-69 mirMAP -0.50658475327409 1.36690059845309e-35 NA NA NA hsa-miR-429 FGF7 2.84108892259147 3.88520896426515e-64 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.366295181453287 6.14104708947163e-38 NA NA NA hsa-miR-182-5p FGF9 2.36408084103818 2.60011457600281e-72 -2.4852262043005 1.90052930236681e-24 miRTarBase;miRNATAP -0.452581728187924 1.53870203091154e-14 NA NA NA hsa-miR-183-5p FGF9 2.95681814393872 1.09965777344285e-92 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.421051105687966 5.55191507820402e-16 NA NA NA hsa-miR-429 FGF9 2.84108892259147 3.88520896426515e-64 -2.4852262043005 1.90052930236681e-24 miRanda -0.319482141660943 1.05794965240276e-11 NA NA NA hsa-miR-96-5p FGF9 3.24596558166606 1.92296159041707e-98 -2.4852262043005 1.90052930236681e-24 TargetScan;miRNATAP -0.44484666162403 4.74837998245841e-20 NA NA NA hsa-miR-200a-5p FGFR1 2.58844508672328 1.79650654234569e-56 -1.14663914385064 6.08915041092458e-18 mirMAP -0.215721842068481 1.13267932151434e-16 NA NA NA hsa-miR-139-5p FGFR1OP -3.25846663863766 2.62018989415003e-112 0.835740357565021 1.33585113706353e-27 miRanda -0.158864532595636 1.56351824620498e-23 NA NA NA hsa-miR-337-3p FGFR3 -2.14274617598363 2.70942896809734e-43 1.86754699235588 2.21866053477893e-14 MirTarget -0.276342803887382 8.88392937600617e-08 NA NA NA hsa-miR-99a-5p FGFR3 -2.25079447371102 1.14086813185885e-54 1.86754699235588 2.21866053477893e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320837636799125 4.30235413296182e-09 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-429 FGL2 2.84108892259147 3.88520896426515e-64 -1.53660090766871 6.54398428523973e-28 miRNATAP -0.291393118674169 6.63644907124165e-28 NA NA NA hsa-miR-200b-3p FHL1 2.11744072703209 1.66710572104191e-43 -4.39641190571109 2.95720924032036e-115 MirTarget -0.744315582307958 1.69874929324822e-65 NA NA NA hsa-miR-200c-3p FHL1 2.07038651806183 6.84613386286599e-51 -4.39641190571109 2.95720924032036e-115 MirTarget -0.950076194934803 5.31550297000954e-94 NA NA NA hsa-miR-429 FHL1 2.84108892259147 3.88520896426515e-64 -4.39641190571109 2.95720924032036e-115 MirTarget;miRanda;miRNATAP -0.701131105430921 2.80962444317132e-74 NA NA NA hsa-miR-96-5p FHL1 3.24596558166606 1.92296159041707e-98 -4.39641190571109 2.95720924032036e-115 TargetScan -0.777493458575286 4.68122666350478e-86 NA NA NA hsa-miR-200c-3p FHOD1 2.07038651806183 6.84613386286599e-51 0.172964188564771 0.0354183224027716 miRNAWalker2_validate -0.113582055183826 2.29895309973769e-09 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-335-5p FIBCD1 -2.61355235628987 2.6462884165886e-51 2.40198386879255 1.010388235145e-14 miRNAWalker2_validate -0.445082181897686 1.32264436506665e-14 NA NA NA hsa-miR-429 FIBIN 2.84108892259147 3.88520896426515e-64 -0.703577414239304 7.26535366199383e-06 miRanda;miRNATAP -0.245528222893041 5.5404021118146e-17 NA NA NA hsa-miR-182-5p FIGN 2.36408084103818 2.60011457600281e-72 -2.43971791427329 1.33964701286684e-33 mirMAP -0.427827479061172 3.37901597403489e-18 NA NA NA hsa-miR-200b-3p FIGN 2.11744072703209 1.66710572104191e-43 -2.43971791427329 1.33964701286684e-33 MirTarget;TargetScan -0.3086064903629 2.68535224605977e-12 NA NA NA hsa-miR-200c-3p FIGN 2.07038651806183 6.84613386286599e-51 -2.43971791427329 1.33964701286684e-33 MirTarget -0.366212076105834 3.8753590581544e-14 NA NA NA hsa-miR-21-5p FIGN 2.32007501846389 3.08394781855554e-137 -2.43971791427329 1.33964701286684e-33 miRNAWalker2_validate -0.632911145569647 4.11498669350143e-23 NA NA NA hsa-miR-429 FIGN 2.84108892259147 3.88520896426515e-64 -2.43971791427329 1.33964701286684e-33 MirTarget;PITA;miRanda -0.273965570153936 3.62210997104187e-12 NA NA NA hsa-miR-200b-3p FIGNL2 2.11744072703209 1.66710572104191e-43 -1.10908313704482 2.31754860335187e-22 MirTarget -0.207168682643263 1.87481290546471e-17 NA NA NA hsa-miR-200c-3p FIGNL2 2.07038651806183 6.84613386286599e-51 -1.10908313704482 2.31754860335187e-22 MirTarget -0.294790594129615 5.73968702863584e-29 NA NA NA hsa-miR-429 FIGNL2 2.84108892259147 3.88520896426515e-64 -1.10908313704482 2.31754860335187e-22 MirTarget;miRanda -0.212183628847416 9.28142726753375e-23 NA NA NA hsa-miR-429 FILIP1 2.84108892259147 3.88520896426515e-64 -1.50260587541837 1.45730457586816e-28 miRanda -0.30698335359914 2.87818703552136e-33 NA NA NA hsa-miR-21-5p FILIP1L 2.32007501846389 3.08394781855554e-137 -1.4255511569533 1.72215103757859e-27 miRNAWalker2_validate -0.239635659978444 1.14540694695997e-08 NA NA NA hsa-miR-429 FILIP1L 2.84108892259147 3.88520896426515e-64 -1.4255511569533 1.72215103757859e-27 miRNATAP -0.305737681769756 2.19237889652308e-35 NA NA NA hsa-miR-10b-5p FIZ1 -2.10996264627796 7.36811595736367e-72 0.550310934972631 1.00413537590167e-18 miRNATAP -0.114790960732363 6.98397978435558e-12 NA NA NA hsa-miR-200b-3p FKBP14 2.11744072703209 1.66710572104191e-43 -0.131038750294068 0.167370353404485 mirMAP -0.163926566035403 1.05075402286229e-16 NA NA NA hsa-miR-200c-3p FKBP14 2.07038651806183 6.84613386286599e-51 -0.131038750294068 0.167370353404485 mirMAP -0.171110973771157 3.7988121456562e-15 NA NA NA hsa-miR-429 FKBP14 2.84108892259147 3.88520896426515e-64 -0.131038750294068 0.167370353404485 mirMAP -0.108482084105915 1.10602767204383e-09 NA NA NA hsa-miR-141-3p FKBP5 2.99777540204168 1.26370498493024e-78 -0.910640773205637 6.12828690619755e-09 TargetScan -0.181359586066222 2.67907589087188e-09 NA NA NA hsa-miR-21-5p FKBP5 2.32007501846389 3.08394781855554e-137 -0.910640773205637 6.12828690619755e-09 miRNAWalker2_validate -0.185035856461726 0.000168306104029105 NA NA NA hsa-miR-96-5p FKBP7 3.24596558166606 1.92296159041707e-98 -0.374609995276024 5.4460531928738e-07 MirTarget -0.108826530536503 1.11526407590051e-13 NA NA NA hsa-miR-429 FKBP9 2.84108892259147 3.88520896426515e-64 -0.244276845713531 0.000115068322205501 miRanda -0.100541688290015 1.46635225561716e-17 NA NA NA hsa-miR-141-3p FLI1 2.99777540204168 1.26370498493024e-78 -1.26235715548629 4.88985347259214e-39 TargetScan -0.32279791085111 7.55604268824049e-72 NA NA NA hsa-miR-200b-3p FLI1 2.11744072703209 1.66710572104191e-43 -1.26235715548629 4.88985347259214e-39 MirTarget;TargetScan -0.289627913352371 3.97191849335038e-46 NA NA NA hsa-miR-200c-3p FLI1 2.07038651806183 6.84613386286599e-51 -1.26235715548629 4.88985347259214e-39 MirTarget;miRNATAP -0.344352033600828 8.39565566372828e-55 NA NA NA hsa-miR-429 FLI1 2.84108892259147 3.88520896426515e-64 -1.26235715548629 4.88985347259214e-39 MirTarget;PITA;miRanda;miRNATAP -0.261261925093117 3.71502744554453e-47 NA NA NA hsa-miR-200c-3p FLNA 2.07038651806183 6.84613386286599e-51 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.200293197507804 3.85868552345297e-17 NA NA NA hsa-miR-145-5p FLRT1 -2.62703571936687 7.64402900188551e-88 0.229763079908531 0.0959873153649617 MirTarget -0.112271031696962 0.000453704755409779 NA NA NA hsa-miR-429 FLRT2 2.84108892259147 3.88520896426515e-64 -2.19668044508393 2.75974820379594e-40 miRanda -0.457742281107593 2.25217640527627e-49 NA NA NA hsa-miR-183-5p FLRT3 2.95681814393872 1.09965777344285e-92 -0.967081377539717 0.000184074180049239 miRNATAP -0.139053298317625 0.0110314419804446 NA NA NA hsa-miR-429 FLRT3 2.84108892259147 3.88520896426515e-64 -0.967081377539717 0.000184074180049239 miRanda -0.119559420013855 0.0150548656888989 NA NA NA hsa-miR-200b-3p FLT1 2.11744072703209 1.66710572104191e-43 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.237387253520266 3.06104626134544e-30 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 2.07038651806183 6.84613386286599e-51 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;miRTarBase;MirTarget -0.255668357647663 5.50361375778068e-29 NA NA NA hsa-miR-429 FLT1 2.84108892259147 3.88520896426515e-64 -0.976682151789582 4.79604479745106e-23 MirTarget;miRanda;miRNATAP -0.212494365543953 2.16632813796484e-30 NA NA NA hsa-miR-429 FLT4 2.84108892259147 3.88520896426515e-64 -1.21716420627977 1.17202457914118e-32 miRanda;miRNATAP -0.220062777103595 1.23886320860694e-29 NA NA NA hsa-miR-337-3p FLVCR1 -2.14274617598363 2.70942896809734e-43 1.30642131036125 5.63542955422088e-36 MirTarget -0.119342719967124 1.4085320935371e-07 NA NA NA hsa-miR-21-5p FMN1 2.32007501846389 3.08394781855554e-137 -0.0957566635721769 0.62995528263914 miRNATAP -0.157357633611186 0.0110643486482957 NA NA NA hsa-miR-429 FMNL2 2.84108892259147 3.88520896426515e-64 -1.42122439444893 7.57688645528653e-33 miRanda -0.195453391502383 2.2030705213871e-17 NA NA NA hsa-miR-141-5p FMNL3 2.38411349683216 4.56310582620282e-58 -0.123925129881515 0.0938026409239178 mirMAP -0.106602222320385 1.05892293493664e-11 NA NA NA hsa-miR-182-5p FMNL3 2.36408084103818 2.60011457600281e-72 -0.123925129881515 0.0938026409239178 miRNAWalker2_validate -0.113052544172958 8.56351091452132e-11 NA NA NA hsa-miR-429 FMNL3 2.84108892259147 3.88520896426515e-64 -0.123925129881515 0.0938026409239178 miRNATAP -0.120897673895897 1.11126808770594e-18 NA NA NA hsa-miR-182-5p FMO2 2.36408084103818 2.60011457600281e-72 -4.4404087637002 7.91152237376595e-70 MirTarget -0.787821629863984 2.92308433927204e-36 NA NA NA hsa-miR-21-5p FMOD 2.32007501846389 3.08394781855554e-137 -1.5830220066125 1.49258819797672e-21 miRNAWalker2_validate;miRTarBase -0.391125968145743 7.97182814844372e-14 23445447;19906824 Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members;Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells ; breast cancer;sarcoma hsa-miR-429 FMOD 2.84108892259147 3.88520896426515e-64 -1.5830220066125 1.49258819797672e-21 miRNATAP -0.329630400497878 6.4012072914873e-26 NA NA NA hsa-miR-139-5p FN1 -3.25846663863766 2.62018989415003e-112 2.70001074183699 2.543883061007e-54 miRanda -0.510579303686055 6.29670431922458e-45 NA NA NA hsa-miR-511-5p FN1 -2.27545475897362 3.84085514050558e-36 2.70001074183699 2.543883061007e-54 MirTarget -0.10476429635028 0.00200343663280643 NA NA NA hsa-miR-335-5p FNDC1 -2.61355235628987 2.6462884165886e-51 1.81924657365459 4.1384256091842e-22 miRNAWalker2_validate -0.278154409544927 3.49163212609518e-15 NA NA NA hsa-miR-141-3p FNDC3B 2.99777540204168 1.26370498493024e-78 -0.617097925266489 2.23433634850295e-11 MirTarget;TargetScan -0.131420157531359 2.06868214521734e-13 NA NA NA hsa-miR-182-5p FNDC3B 2.36408084103818 2.60011457600281e-72 -0.617097925266489 2.23433634850295e-11 MirTarget;mirMAP;miRNATAP -0.191412462296199 1.55280570828593e-18 NA NA NA hsa-miR-183-5p FNDC3B 2.95681814393872 1.09965777344285e-92 -0.617097925266489 2.23433634850295e-11 miRNATAP -0.112877702558439 7.30883660178657e-09 NA NA NA hsa-miR-200a-3p FNDC3B 2.55218480823434 2.96135446816238e-51 -0.617097925266489 2.23433634850295e-11 MirTarget -0.122330732120618 3.48253775867492e-12 NA NA NA hsa-miR-200b-3p FNDC3B 2.11744072703209 1.66710572104191e-43 -0.617097925266489 2.23433634850295e-11 MirTarget;TargetScan -0.156400322557984 9.38003443415968e-16 NA NA NA hsa-miR-200c-3p FNDC3B 2.07038651806183 6.84613386286599e-51 -0.617097925266489 2.23433634850295e-11 MirTarget;miRNATAP -0.168526971666725 3.63146291373359e-15 NA NA NA hsa-miR-429 FNDC3B 2.84108892259147 3.88520896426515e-64 -0.617097925266489 2.23433634850295e-11 MirTarget;PITA;miRanda;miRNATAP -0.106579650926379 1.18545332115615e-09 NA NA NA hsa-miR-96-5p FNDC3B 3.24596558166606 1.92296159041707e-98 -0.617097925266489 2.23433634850295e-11 TargetScan;miRNATAP -0.145982151376786 8.53853441610663e-16 NA NA NA hsa-miR-429 FNDC4 2.84108892259147 3.88520896426515e-64 -1.47818616720281 4.78491235681217e-27 miRNATAP -0.252047299586533 6.77517646134987e-22 NA NA NA hsa-miR-429 FNDC5 2.84108892259147 3.88520896426515e-64 -1.21066427398314 3.59010143818635e-17 miRNATAP -0.218692198532414 1.16094166044682e-15 NA NA NA hsa-miR-141-3p FNIP2 2.99777540204168 1.26370498493024e-78 -1.39702732424967 8.59594770424294e-21 TargetScan -0.280599316860777 4.16722031597609e-22 NA NA NA hsa-miR-375 FOLR1 2.09893673049766 1.68351780396203e-16 -2.68199467622154 6.42992410257734e-13 miRNAWalker2_validate -0.328280997830411 2.98413582040085e-11 NA NA NA hsa-miR-149-5p FOSL1 0.218233101703391 0.261629158371175 -0.625166609380041 0.00118665801767194 MirTarget;miRNATAP -0.217220245133133 1.20539701452285e-10 NA NA NA hsa-miR-342-3p FOSL1 1.21944481975657 6.81914373001202e-19 -0.625166609380041 0.00118665801767194 miRanda -0.403573240229472 2.83490772906014e-18 NA NA NA hsa-miR-96-5p FOSL2 3.24596558166606 1.92296159041707e-98 -0.30075488558279 0.000652385145308852 TargetScan -0.103535657572231 2.30769705860615e-09 NA NA NA hsa-miR-335-5p FOXA3 -2.61355235628987 2.6462884165886e-51 0.550819545269799 0.057467549068525 miRNAWalker2_validate -0.16178793069399 0.00267185055656749 NA NA NA hsa-miR-141-3p FOXC1 2.99777540204168 1.26370498493024e-78 -1.56967295609977 3.50287816253511e-14 TargetScan -0.153905479977761 0.000164426354303397 NA NA NA hsa-miR-200a-5p FOXC1 2.58844508672328 1.79650654234569e-56 -1.56967295609977 3.50287816253511e-14 miRNATAP -0.15195587834815 0.000213405349515204 NA NA NA hsa-miR-375 FOXC1 2.09893673049766 1.68351780396203e-16 -1.56967295609977 3.50287816253511e-14 miRanda -0.392339462923658 3.22168211235317e-51 NA NA NA hsa-miR-335-5p FOXD2 -2.61355235628987 2.6462884165886e-51 1.4663265566426 1.0528871170585e-19 miRNAWalker2_validate -0.16918185099522 2.87838550672622e-08 NA NA NA hsa-miR-511-5p FOXD2 -2.27545475897362 3.84085514050558e-36 1.4663265566426 1.0528871170585e-19 MirTarget -0.201210675535562 1.34717016995045e-11 NA NA NA hsa-miR-335-5p FOXD3 -2.61355235628987 2.6462884165886e-51 1.99542651370526 5.39029066331881e-12 miRNAWalker2_validate -0.303117245349577 2.12409532575563e-08 NA NA NA hsa-miR-145-5p FOXD4 -2.62703571936687 7.64402900188551e-88 1.71498662665658 1.83047665294251e-29 MirTarget -0.346975415639868 2.72569411358494e-22 NA NA NA hsa-miR-145-5p FOXD4L1 -2.62703571936687 7.64402900188551e-88 1.76876840447172 2.27012134835503e-33 MirTarget -0.378003056136083 4.66714655846817e-28 NA NA NA hsa-miR-200b-3p FOXF1 2.11744072703209 1.66710572104191e-43 0.291118837928196 0.0286763951936233 MirTarget;TargetScan -0.14491240041732 2.45591589496998e-07 NA NA NA hsa-miR-200c-3p FOXF1 2.07038651806183 6.84613386286599e-51 0.291118837928196 0.0286763951936233 MirTarget -0.150915017821127 1.04078828830041e-06 NA NA NA hsa-miR-429 FOXF1 2.84108892259147 3.88520896426515e-64 0.291118837928196 0.0286763951936233 MirTarget;PITA;miRanda -0.107672283734361 1.83666441327599e-05 NA NA NA hsa-miR-182-5p FOXF2 2.36408084103818 2.60011457600281e-72 0.0862026827601208 0.512388199995853 miRNAWalker2_validate;miRNATAP -0.119095745209746 0.000139290004904651 25738520 miR 182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer; In the present study we aimed to investigate the role of miR-182 in colorectal cancer CRC and identify the regulation of FoxF2 by miR-182; The direct binding of miR-182 to the 3' untranslated region 3'UTR of FoxF2 mRNA was confirmed using a luciferase reporter gene assay colorectal cancer hsa-miR-200b-3p FOXF2 2.11744072703209 1.66710572104191e-43 0.0862026827601208 0.512388199995853 TargetScan -0.121362215613563 1.26130100638394e-05 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2 metastasis lung cancer hsa-miR-200c-3p FOXF2 2.07038651806183 6.84613386286599e-51 0.0862026827601208 0.512388199995853 miRNATAP -0.160981197343451 1.28422651580948e-07 NA NA NA hsa-miR-429 FOXF2 2.84108892259147 3.88520896426515e-64 0.0862026827601208 0.512388199995853 PITA;miRanda;miRNATAP -0.119934889712944 1.30641979177401e-06 NA NA NA hsa-miR-96-5p FOXF2 3.24596558166606 1.92296159041707e-98 0.0862026827601208 0.512388199995853 TargetScan;miRNATAP -0.136902510305272 1.16609748055901e-07 NA NA NA hsa-miR-182-5p FOXN2 2.36408084103818 2.60011457600281e-72 -1.15146301932722 1.86981509490569e-31 MirTarget -0.272297403653494 6.41725532275167e-31 NA NA NA hsa-miR-183-5p FOXN2 2.95681814393872 1.09965777344285e-92 -1.15146301932722 1.86981509490569e-31 miRNAWalker2_validate;MirTarget;miRNATAP -0.169940430266794 1.29137653434279e-15 NA NA NA hsa-miR-200b-3p FOXN2 2.11744072703209 1.66710572104191e-43 -1.15146301932722 1.86981509490569e-31 TargetScan -0.216067297784938 1.6207167544195e-24 NA NA NA hsa-miR-429 FOXN2 2.84108892259147 3.88520896426515e-64 -1.15146301932722 1.86981509490569e-31 miRanda;miRNATAP -0.174714338643623 3.54405850449815e-20 NA NA NA hsa-miR-141-3p FOXN3 2.99777540204168 1.26370498493024e-78 -1.6997111136462 5.59981199956681e-76 MirTarget;TargetScan;miRNATAP -0.346154028249218 5.50654100716566e-85 NA NA NA hsa-miR-141-5p FOXN3 2.38411349683216 4.56310582620282e-58 -1.6997111136462 5.59981199956681e-76 mirMAP -0.310052420271737 4.4070571868471e-52 NA NA NA hsa-miR-182-5p FOXN3 2.36408084103818 2.60011457600281e-72 -1.6997111136462 5.59981199956681e-76 MirTarget;miRNATAP -0.356013373360749 3.07903984244243e-56 NA NA NA hsa-miR-200a-3p FOXN3 2.55218480823434 2.96135446816238e-51 -1.6997111136462 5.59981199956681e-76 MirTarget;miRNATAP -0.309014315126777 9.68107206991495e-68 NA NA NA hsa-miR-200b-3p FOXN3 2.11744072703209 1.66710572104191e-43 -1.6997111136462 5.59981199956681e-76 mirMAP -0.331522889759846 2.61605387533255e-62 NA NA NA hsa-miR-21-5p FOXN3 2.32007501846389 3.08394781855554e-137 -1.6997111136462 5.59981199956681e-76 miRNAWalker2_validate;mirMAP -0.372367413731894 1.09993935350141e-34 NA NA NA hsa-miR-429 FOXN3 2.84108892259147 3.88520896426515e-64 -1.6997111136462 5.59981199956681e-76 miRNATAP -0.304240754949731 2.24957994017243e-66 NA NA NA hsa-miR-96-5p FOXN3 3.24596558166606 1.92296159041707e-98 -1.6997111136462 5.59981199956681e-76 TargetScan;miRNATAP -0.335456470544844 1.50913405469638e-75 NA NA NA hsa-miR-141-3p FOXO1 2.99777540204168 1.26370498493024e-78 -1.98726551876693 3.0579805549685e-75 mirMAP -0.419566743640224 5.4571001142745e-92 NA NA NA hsa-miR-182-5p FOXO1 2.36408084103818 2.60011457600281e-72 -1.98726551876693 3.0579805549685e-75 miRNAWalker2_validate;miRTarBase;miRNATAP -0.410047760748846 7.52125884399878e-54 24865442;26640590;23313739 Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;MiR 182 Is Associated with Growth Migration and Invasion in Prostate Cancer via Suppression of FOXO1; Our findings suggest that miR-182 may act to increase prostate cancer proliferation migration and invasion through suppression of FOXO1;Western blot flow cytometry and pathway analysis for the HeLa cells with miR-182 over/down-expression in vitro showed that miR-182 was involved in apoptosis and cell cycle pathways it also associated with the regulation of FOXO1 ;; colon cancer;prostate cancer;cervical and endocervical cancer hsa-miR-183-5p FOXO1 2.95681814393872 1.09965777344285e-92 -1.98726551876693 3.0579805549685e-75 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.397042214565454 3.35421059028432e-66 25813403;25983004 Knockdown of CTNNB1 also showed concordant down-regulations of miR-183 -96 and -182 and the re-expression of FOXO1;MiR 183 promotes growth of non small cell lung cancer cells through FoxO1 inhibition; Here we analyzed the regulation of FoxO1 by miR-183 in vitro using luciferase-reporter assay; Moreover miR-183 bound to FoxO1 mRNA to prevent its translation through its 3'untranslated region UTR; Furthermore administration of miR-183 suppressed FoxO1 levels in NSCLC resulting in a significant increase in NSCLC growth in vitro and in vivo while administration of antisense of miR-183 significantly increased FoxO1 levels in NSCLC resulting in a significant decrease in NSCLC growth ; liver cancer;lung squamous cell cancer hsa-miR-200a-3p FOXO1 2.55218480823434 2.96135446816238e-51 -1.98726551876693 3.0579805549685e-75 mirMAP -0.354580454287537 3.3835357109995e-64 NA NA NA hsa-miR-429 FOXO1 2.84108892259147 3.88520896426515e-64 -1.98726551876693 3.0579805549685e-75 miRanda -0.362840577199436 8.00081469314798e-69 NA NA NA hsa-miR-96-5p FOXO1 3.24596558166606 1.92296159041707e-98 -1.98726551876693 3.0579805549685e-75 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.405201432535649 6.86289849762902e-81 23741253;24260486;23951320;26617698;24633705;27164937 miR 96 regulates FOXO1 mediated cell apoptosis in bladder cancer; In the present study we used microRNA miRNA target prediction algorithms to identify a conserved potential miR-96 binding site in the 3'-untranslated region 3'-UTR of FOXO1; To confirm this we transfected pre-miR-96/anti-miR-96 into the T24 TCC cell line and revealed that miR-96 expression was sufficient to significantly reduce FOXO1 expression; Conversely FOXO1 expression was not completely restored by the inhibition of miR-96 in T24 cells; Moreover RNA silencing of FOXO1 significantly reduced miR-96 inhibitor-mediated T24 cell apoptosis;The antiapoptotic function of miR 96 in prostate cancer by inhibition of FOXO1; In silico target prediction analysis identified FOXO1 as potential pro-apoptotic miR-96 target; miR-96 was able to bind to both bindings sites in the FOXO1 3' UTR in a luciferase reporter gene assay; Overexpression of miR-96 in LNCaP cells resulted in a reduced FOXO1 expression; Overexpression of FOXO1 induced a strong apoptotic phenotype that was partially rescued by coexpression of miR-96; RT-qPCR and immunohistochemistry of 69 prostate cancer specimens revealed a downregulation of FOXO1 and an inverse correlation of miR-96 and FOXO1 protein expression; In conclusion we show that miR-96 can regulate apoptosis in prostate cancer by inhibiting the FOXO1 transcription factor;Upregulation of miR 96 enhances cellular proliferation of prostate cancer cells through FOXO1; We demonstrate that miR-96 expression decreases the transcript and protein levels of FOXO1 by binding to one of two predicted binding sites in the FOXO1 3'UTR sequence; This finding was corroborated in a large external prostate cancer patient cohort where miR-96 expression inversely correlated to FOXO1 expression;MicroRNA 96 plays an oncogenic role by targeting FOXO1 and regulating AKT/FOXO1/Bim pathway in papillary thyroid carcinoma cells; According to a computational prediction FOXO1 maybe a potential target of miR-96; Moreover the expression of FOXO1 had an inverse correlation with expression of miR-96 in PTC specimens by RT-qPCR and western blot analysis;miR 96 promotes cell proliferation and clonogenicity by down regulating of FOXO1 in prostate cancer cells; Inhibition of miR-96 caused expression increase of tumor suppressor gene FOXO1 thus manipulating miR-96 expression may be a promising approach in treatment of prostate cancer;Among the identified tumor-promoting miRNAs miR-96 has been well established to contribute to PC by reducing FOXO1 expression ;;;;; bladder cancer;prostate cancer;prostate cancer;thyroid cancer;prostate cancer;prostate cancer hsa-miR-429 FOXO4 2.84108892259147 3.88520896426515e-64 -1.05595514672013 4.31153744833776e-38 miRNATAP -0.115688900706391 5.27951610832256e-13 NA NA NA hsa-miR-96-5p FOXO4 3.24596558166606 1.92296159041707e-98 -1.05595514672013 4.31153744833776e-38 MirTarget;TargetScan;miRNATAP -0.14501869664246 2.56351910068554e-18 NA NA NA hsa-miR-141-3p FOXP2 2.99777540204168 1.26370498493024e-78 -3.10671503377831 7.7457852611569e-43 TargetScan -0.612782679753809 4.65276045556256e-44 NA NA NA hsa-miR-182-5p FOXP2 2.36408084103818 2.60011457600281e-72 -3.10671503377831 7.7457852611569e-43 miRNATAP -0.597392538615223 2.43716139315113e-27 NA NA NA hsa-miR-200a-5p FOXP2 2.58844508672328 1.79650654234569e-56 -3.10671503377831 7.7457852611569e-43 mirMAP -0.455257987274454 1.21612852607453e-23 NA NA NA hsa-miR-21-5p FOXP2 2.32007501846389 3.08394781855554e-137 -3.10671503377831 7.7457852611569e-43 mirMAP -0.695850593090754 1.03030535022016e-21 NA NA NA hsa-miR-375 FOXP2 2.09893673049766 1.68351780396203e-16 -3.10671503377831 7.7457852611569e-43 miRanda -0.223016255363538 7.68269188732194e-13 NA NA NA hsa-miR-429 FOXP2 2.84108892259147 3.88520896426515e-64 -3.10671503377831 7.7457852611569e-43 miRNATAP -0.531276087016921 2.10720409002638e-34 NA NA NA hsa-miR-96-5p FOXP2 3.24596558166606 1.92296159041707e-98 -3.10671503377831 7.7457852611569e-43 TargetScan -0.596208167570797 4.61688796854034e-40 NA NA NA hsa-miR-335-5p FOXQ1 -2.61355235628987 2.6462884165886e-51 0.497719648516172 0.0305921132696761 miRNAWalker2_validate -0.245820794613953 7.11838447713367e-09 NA NA NA hsa-miR-99a-5p FOXRED2 -2.25079447371102 1.14086813185885e-54 0.660545405597571 8.97067597254262e-14 miRNAWalker2_validate -0.152593975654514 7.12956471111517e-15 NA NA NA hsa-miR-375 FPR2 2.09893673049766 1.68351780396203e-16 -0.195181879965793 0.38084203077084 miRanda -0.255000934811514 7.51133227235782e-19 NA NA NA hsa-miR-139-5p FPR3 -3.25846663863766 2.62018989415003e-112 0.76881845454896 2.07254502252295e-07 miRanda -0.156160150568113 3.13366849040022e-07 NA NA NA hsa-miR-429 FRAS1 2.84108892259147 3.88520896426515e-64 -1.52646948475972 9.41123797205707e-15 miRanda;miRNATAP -0.175017292983843 3.66933699929865e-06 NA NA NA hsa-miR-1296-5p FRAT1 -0.869145627283619 5.57415904359993e-12 0.327623929715434 0.000441849904706618 MirTarget -0.202422777904563 2.39294268910508e-16 NA NA NA hsa-miR-23b-3p FRAT1 -0.363202401123049 0.000265305319764878 0.327623929715434 0.000441849904706618 miRNATAP -0.272278749887034 6.57021937322535e-18 NA NA NA hsa-miR-125a-5p FRAT2 -0.635694700253268 3.6703235721638e-11 0.922457282169325 9.00183708874933e-33 miRanda -0.122529541273626 1.62004842950428e-05 NA NA NA hsa-miR-125b-5p FRAT2 -1.94393269763542 2.78180543229264e-58 0.922457282169325 9.00183708874933e-33 miRNAWalker2_validate;miRNATAP -0.211438805112806 1.43832131405049e-24 NA NA NA hsa-miR-22-3p FRAT2 -0.505819481364718 1.90494905330622e-13 0.922457282169325 9.00183708874933e-33 miRNAWalker2_validate;MirTarget;miRNATAP -0.282270676456224 8.71182980194614e-13 NA NA NA hsa-miR-26a-5p FRAT2 -0.481180084102235 1.82368246174758e-10 0.922457282169325 9.00183708874933e-33 miRNATAP -0.149885015101282 3.81360261100518e-05 NA NA NA hsa-miR-337-3p FRAT2 -2.14274617598363 2.70942896809734e-43 0.922457282169325 9.00183708874933e-33 MirTarget;PITA -0.167553471806894 1.26273673886636e-24 NA NA NA hsa-miR-182-5p FREM1 2.36408084103818 2.60011457600281e-72 -3.8030010836205 5.39603299975023e-55 miRNATAP -0.715652442005453 5.23561003863811e-33 NA NA NA hsa-miR-429 FREM1 2.84108892259147 3.88520896426515e-64 -3.8030010836205 5.39603299975023e-55 miRanda;miRNATAP -0.625151409760627 3.14520876603166e-40 NA NA NA hsa-miR-96-5p FREM1 3.24596558166606 1.92296159041707e-98 -3.8030010836205 5.39603299975023e-55 TargetScan;miRNATAP -0.782635812771464 5.30469196840517e-60 NA NA NA hsa-miR-200b-3p FREM2 2.11744072703209 1.66710572104191e-43 -1.24367958988493 0.000230765369099563 TargetScan;mirMAP -0.258605468756909 0.000314408791569484 NA NA NA hsa-miR-21-5p FREM2 2.32007501846389 3.08394781855554e-137 -1.24367958988493 0.000230765369099563 mirMAP -0.30072670502533 0.00440939547495692 NA NA NA hsa-miR-429 FREM2 2.84108892259147 3.88520896426515e-64 -1.24367958988493 0.000230765369099563 mirMAP;miRNATAP -0.227925911918026 0.000376625317495532 NA NA NA hsa-miR-200b-3p FRMD3 2.11744072703209 1.66710572104191e-43 -2.57949043338413 1.34979420509153e-35 mirMAP -0.265670397410008 5.59023588171974e-09 NA NA NA hsa-miR-21-5p FRMD3 2.32007501846389 3.08394781855554e-137 -2.57949043338413 1.34979420509153e-35 MirTarget -0.851710692588348 4.58036451272984e-40 NA NA NA hsa-miR-429 FRMD3 2.84108892259147 3.88520896426515e-64 -2.57949043338413 1.34979420509153e-35 mirMAP -0.303412966660976 6.21578538228294e-14 NA NA NA hsa-miR-141-3p FRMD4A 2.99777540204168 1.26370498493024e-78 -1.01645361935313 1.41995569982009e-35 MirTarget;TargetScan;miRNATAP -0.155087652439246 8.62253250371953e-22 NA NA NA hsa-miR-182-5p FRMD4A 2.36408084103818 2.60011457600281e-72 -1.01645361935313 1.41995569982009e-35 miRNATAP -0.224575374561541 2.07113257149136e-30 NA NA NA hsa-miR-200a-3p FRMD4A 2.55218480823434 2.96135446816238e-51 -1.01645361935313 1.41995569982009e-35 MirTarget;miRNATAP -0.151966445379609 9.74481066109446e-22 NA NA NA hsa-miR-200b-3p FRMD4A 2.11744072703209 1.66710572104191e-43 -1.01645361935313 1.41995569982009e-35 MirTarget;TargetScan -0.167102449464382 2.94003680494319e-21 NA NA NA hsa-miR-200c-3p FRMD4A 2.07038651806183 6.84613386286599e-51 -1.01645361935313 1.41995569982009e-35 MirTarget -0.178469341949458 4.37545129528689e-20 NA NA NA hsa-miR-429 FRMD4A 2.84108892259147 3.88520896426515e-64 -1.01645361935313 1.41995569982009e-35 MirTarget;PITA;miRanda;miRNATAP -0.147460392581914 8.98613015298205e-21 NA NA NA hsa-miR-96-5p FRMD4A 3.24596558166606 1.92296159041707e-98 -1.01645361935313 1.41995569982009e-35 TargetScan;miRNATAP -0.175649846986332 5.62855577210311e-27 NA NA NA hsa-miR-200b-3p FRMD4B 2.11744072703209 1.66710572104191e-43 -0.791884465310464 1.80164221616731e-17 TargetScan -0.123399803212915 6.30082911157813e-10 NA NA NA hsa-miR-429 FRMD4B 2.84108892259147 3.88520896426515e-64 -0.791884465310464 1.80164221616731e-17 PITA;miRanda;miRNATAP -0.135489280212918 2.05144487040422e-14 NA NA NA hsa-miR-96-5p FRMD5 3.24596558166606 1.92296159041707e-98 -0.0957638591542056 0.613759848817855 MirTarget;TargetScan -0.116610961725962 0.00185685580506715 NA NA NA hsa-miR-141-3p FRMD6 2.99777540204168 1.26370498493024e-78 -0.866699035031564 6.18218400177215e-15 MirTarget;TargetScan;miRNATAP -0.210703663785569 6.94058503459482e-23 NA NA NA hsa-miR-183-5p FRMD6 2.95681814393872 1.09965777344285e-92 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.167932669842187 9.06663739237668e-13 NA NA NA hsa-miR-200a-3p FRMD6 2.55218480823434 2.96135446816238e-51 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.16417507171658 1.01344056716179e-14 NA NA NA hsa-miR-200b-3p FRMD6 2.11744072703209 1.66710572104191e-43 -0.866699035031564 6.18218400177215e-15 TargetScan -0.151525640921733 1.71424374610769e-10 NA NA NA hsa-miR-200c-3p FRMD6 2.07038651806183 6.84613386286599e-51 -0.866699035031564 6.18218400177215e-15 miRNATAP -0.208288866495126 9.17125871002378e-16 NA NA NA hsa-miR-429 FRMD6 2.84108892259147 3.88520896426515e-64 -0.866699035031564 6.18218400177215e-15 miRanda;miRNATAP -0.180281356981335 8.71143077479489e-18 NA NA NA hsa-miR-429 FRMPD1 2.84108892259147 3.88520896426515e-64 -2.09725846814551 5.12228192216229e-22 miRanda -0.246795444045152 4.06093743088529e-09 NA NA NA hsa-miR-141-3p FRY 2.99777540204168 1.26370498493024e-78 -1.13354365828084 2.35583827383817e-18 miRNATAP -0.199769479412601 3.26827769248094e-15 NA NA NA hsa-miR-200a-3p FRY 2.55218480823434 2.96135446816238e-51 -1.13354365828084 2.35583827383817e-18 miRNATAP -0.152089514355465 1.28001824319125e-09 NA NA NA hsa-miR-429 FRZB 2.84108892259147 3.88520896426515e-64 -0.831260183338522 3.60366652058703e-07 miRNATAP -0.169689461628245 4.18182629419567e-08 NA NA NA hsa-miR-335-5p FSCN2 -2.61355235628987 2.6462884165886e-51 0.820879515885647 4.00848242313536e-06 miRNAWalker2_validate -0.181015395838655 4.27918198561689e-08 NA NA NA hsa-miR-200b-3p FSTL1 2.11744072703209 1.66710572104191e-43 -1.28139008179553 1.01404950224375e-26 MirTarget;TargetScan -0.360497287154624 3.72936436031533e-48 NA NA NA hsa-miR-200c-3p FSTL1 2.07038651806183 6.84613386286599e-51 -1.28139008179553 1.01404950224375e-26 MirTarget -0.453998296697041 2.3449872421462e-65 NA NA NA hsa-miR-429 FSTL1 2.84108892259147 3.88520896426515e-64 -1.28139008179553 1.01404950224375e-26 MirTarget;PITA;miRanda -0.295290167774316 5.67693174134047e-40 NA NA NA hsa-miR-335-5p FTCD -2.61355235628987 2.6462884165886e-51 0.553148537270605 0.0228942709856903 miRNAWalker2_validate -0.167106003303224 0.000213148565889699 NA NA NA hsa-miR-141-3p FTO 2.99777540204168 1.26370498493024e-78 -1.00223220745244 1.98834905469873e-28 mirMAP -0.119852449581978 3.00395404384543e-11 NA NA NA hsa-miR-141-5p FTO 2.38411349683216 4.56310582620282e-58 -1.00223220745244 1.98834905469873e-28 mirMAP -0.105404714725155 1.40256411234615e-07 NA NA NA hsa-miR-182-5p FTO 2.36408084103818 2.60011457600281e-72 -1.00223220745244 1.98834905469873e-28 mirMAP -0.124773829326375 1.86767093190567e-08 NA NA NA hsa-miR-96-5p FTO 3.24596558166606 1.92296159041707e-98 -1.00223220745244 1.98834905469873e-28 mirMAP -0.138624939784155 3.25306309671705e-14 NA NA NA hsa-miR-139-5p FUNDC1 -3.25846663863766 2.62018989415003e-112 0.720379856975189 8.24730725775292e-26 miRanda -0.139720157986153 6.05423859610758e-23 NA NA NA hsa-miR-10b-5p FUS -2.10996264627796 7.36811595736367e-72 0.928819102936536 5.45276716664475e-44 MirTarget -0.206927968099292 3.11590238229457e-30 NA NA NA hsa-miR-141-5p FUT4 2.38411349683216 4.56310582620282e-58 -0.679443089509878 4.66310915975363e-15 mirMAP -0.146525160944746 3.68223946422036e-15 NA NA NA hsa-miR-200b-3p FUT4 2.11744072703209 1.66710572104191e-43 -0.679443089509878 4.66310915975363e-15 TargetScan -0.129088310698467 2.76147215488589e-12 NA NA NA hsa-miR-96-5p FUT9 3.24596558166606 1.92296159041707e-98 -1.19371882794782 0.000109654647853888 TargetScan -0.150628701772126 0.0139742243942678 NA NA NA hsa-miR-10b-5p FXR2 -2.10996264627796 7.36811595736367e-72 0.128356201140035 0.0334971023525647 miRNATAP -0.103597191916515 7.12527692734154e-11 NA NA NA hsa-miR-141-3p FYCO1 2.99777540204168 1.26370498493024e-78 -0.837636641815681 9.41294109419175e-23 mirMAP -0.175826275085786 1.74617797613534e-26 NA NA NA hsa-miR-200a-3p FYCO1 2.55218480823434 2.96135446816238e-51 -0.837636641815681 9.41294109419175e-23 mirMAP -0.133059467373794 5.43462096573711e-16 NA NA NA hsa-miR-429 FYCO1 2.84108892259147 3.88520896426515e-64 -0.837636641815681 9.41294109419175e-23 miRNATAP -0.159136288987325 7.2122407357028e-23 NA NA NA hsa-miR-96-5p FYCO1 3.24596558166606 1.92296159041707e-98 -0.837636641815681 9.41294109419175e-23 TargetScan;miRNATAP -0.124607658213732 3.064947882506e-13 NA NA NA hsa-miR-200b-3p FYN 2.11744072703209 1.66710572104191e-43 -0.965287085760175 3.05410879931046e-23 TargetScan -0.256321683539745 1.20065225224339e-36 NA NA NA hsa-miR-200c-3p FYN 2.07038651806183 6.84613386286599e-51 -0.965287085760175 3.05410879931046e-23 miRNATAP -0.314645625793321 2.33665324756776e-46 NA NA NA hsa-miR-429 FYN 2.84108892259147 3.88520896426515e-64 -0.965287085760175 3.05410879931046e-23 miRanda;miRNATAP -0.204625438012807 4.45911067607035e-29 NA NA NA hsa-miR-96-5p FYN 3.24596558166606 1.92296159041707e-98 -0.965287085760175 3.05410879931046e-23 TargetScan;miRNATAP -0.254786111393811 5.32734929134646e-42 NA NA NA hsa-miR-29b-3p FZD1 0.438847962603729 6.46722433236121e-05 -0.348990746009524 0.000632040029652186 mirMAP -0.142292816540562 7.62954986745634e-06 NA NA NA hsa-miR-29c-3p FZD1 -0.0652732378039769 0.563774115756922 -0.348990746009524 0.000632040029652186 mirMAP -0.218168403933287 1.2823801399907e-12 NA NA NA hsa-miR-107 FZD10 0.678998026350662 2.56224148930538e-16 -0.317555738920769 0.0719106519916973 miRanda -0.400790225805032 2.23315200602984e-08 NA NA NA hsa-miR-15b-5p FZD10 0.788659356634696 1.13678211092534e-11 -0.317555738920769 0.0719106519916973 miRNATAP -0.294791552759113 8.30312298544766e-09 NA NA NA hsa-miR-16-5p FZD10 0.46835991343556 1.91125356547776e-06 -0.317555738920769 0.0719106519916973 miRNATAP -0.205587202208207 0.000809635155549991 NA NA NA hsa-miR-25-3p FZD10 -0.00546790775985073 0.944061771389468 -0.317555738920769 0.0719106519916973 miRNATAP -0.348866342513126 7.96845323691697e-06 NA NA NA hsa-miR-32-5p FZD10 1.38676603945192 2.29428299685976e-34 -0.317555738920769 0.0719106519916973 miRNATAP -0.123938793775156 0.0156379360391019 NA NA NA hsa-miR-455-3p FZD10 0.678392920628872 0.000327758844555877 -0.317555738920769 0.0719106519916973 PITA;miRNATAP -0.126579766449709 7.04423244264842e-05 NA NA NA hsa-miR-92a-3p FZD10 -0.342420481092807 0.000732275969501111 -0.317555738920769 0.0719106519916973 miRNATAP -0.296950048447328 5.92314304840851e-07 NA NA NA hsa-miR-92b-3p FZD10 1.30248132773644 9.42428674470985e-25 -0.317555738920769 0.0719106519916973 miRNATAP -0.138813280698489 0.00275447570293217 NA NA NA hsa-miR-98-5p FZD10 0.656336869298973 9.03113188590466e-15 -0.317555738920769 0.0719106519916973 miRNAWalker2_validate -0.461667265087064 4.29163451584181e-11 NA NA NA hsa-miR-103a-3p FZD3 0.610673390034345 1.63113920514646e-12 0.141330043289239 0.271890100649809 MirTarget -0.217217198769376 1.65600292637449e-05 NA NA NA hsa-miR-107 FZD3 0.678998026350662 2.56224148930538e-16 0.141330043289239 0.271890100649809 MirTarget;miRanda -0.179768540730773 0.00061594712979082 NA NA NA hsa-miR-139-5p FZD3 -3.25846663863766 2.62018989415003e-112 0.141330043289239 0.271890100649809 PITA;miRanda -0.114417639453248 1.43759918418206e-05 NA NA NA hsa-miR-16-2-3p FZD3 0.286355254959005 0.0256946046884474 0.141330043289239 0.271890100649809 mirMAP -0.131652726734944 0.000136576830732616 NA NA NA hsa-miR-335-3p FZD3 -1.88448538773649 2.09538234398335e-32 0.141330043289239 0.271890100649809 MirTarget;mirMAP -0.113655440180937 1.86044682903159e-05 NA NA NA hsa-miR-338-3p FZD3 0.0799903526884966 0.575137668326679 0.141330043289239 0.271890100649809 PITA;miRanda -0.111182152623386 0.000317238435661394 NA NA NA hsa-miR-361-5p FZD3 -0.0996867547900457 0.095428250126326 0.141330043289239 0.271890100649809 miRanda;miRNATAP -0.262866332902642 0.000447138915298169 NA NA NA hsa-miR-374a-5p FZD3 -0.239709888246804 0.00309819667153627 0.141330043289239 0.271890100649809 mirMAP -0.182913725946331 0.00081843481388181 NA NA NA hsa-miR-374b-5p FZD3 -0.466781429946153 1.17238311619116e-08 0.141330043289239 0.271890100649809 mirMAP -0.120532507815516 0.025152765687485 NA NA NA hsa-let-7a-3p FZD4 0.466622567891891 3.70886257943079e-07 -2.45778080887863 8.2466362913083e-83 mirMAP -0.407977804308959 4.19813220404563e-15 NA NA NA hsa-let-7d-5p FZD4 0.410958462607207 6.07808182756787e-06 -2.45778080887863 8.2466362913083e-83 MirTarget;miRNATAP -0.378548770288792 7.31572406282056e-13 NA NA NA hsa-let-7e-5p FZD4 0.261471269338985 0.00191077095550257 -2.45778080887863 8.2466362913083e-83 MirTarget;miRNATAP -0.142834413823916 0.0136912438497173 NA NA NA hsa-let-7f-1-3p FZD4 0.37532726250321 0.00156021688753682 -2.45778080887863 8.2466362913083e-83 mirMAP -0.196958732723448 1.81775392431145e-06 NA NA NA hsa-let-7g-3p FZD4 0.5854327663695 0.000371711766083627 -2.45778080887863 8.2466362913083e-83 MirTarget;miRNATAP -0.181060509538746 5.2893212751556e-10 NA NA NA hsa-miR-106b-5p FZD4 1.22477789913175 2.31787213143326e-32 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.578879980215605 3.05048677233544e-41 NA NA NA hsa-miR-107 FZD4 0.678998026350662 2.56224148930538e-16 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.462830534136136 4.14785600961069e-16 NA NA NA hsa-miR-130b-3p FZD4 1.38122163823846 1.00932179737836e-26 -2.45778080887863 8.2466362913083e-83 mirMAP -0.413297584170443 1.17616241857261e-31 NA NA NA hsa-miR-132-3p FZD4 -0.0365213889238607 0.668598301088667 -2.45778080887863 8.2466362913083e-83 mirMAP -0.131849182622165 0.0215519807956623 NA NA NA hsa-miR-141-3p FZD4 2.99777540204168 1.26370498493024e-78 -2.45778080887863 8.2466362913083e-83 TargetScan -0.485144243770508 8.88244662789011e-86 NA NA NA hsa-miR-15a-5p FZD4 0.812445324157528 4.50263417099822e-20 -2.45778080887863 8.2466362913083e-83 MirTarget -0.396430785367124 8.19331587254851e-14 NA NA NA hsa-miR-15b-5p FZD4 0.788659356634696 1.13678211092534e-11 -2.45778080887863 8.2466362913083e-83 MirTarget -0.335171646720997 1.57029090717913e-16 NA NA NA hsa-miR-16-5p FZD4 0.46835991343556 1.91125356547776e-06 -2.45778080887863 8.2466362913083e-83 MirTarget -0.244461027478749 6.1956298490801e-07 NA NA NA hsa-miR-17-3p FZD4 0.721439431208839 7.95900548819742e-10 -2.45778080887863 8.2466362913083e-83 MirTarget -0.488528178794328 1.80113152001825e-35 NA NA NA hsa-miR-17-5p FZD4 0.599531757298529 1.07318660415906e-05 -2.45778080887863 8.2466362913083e-83 TargetScan -0.379930791437764 1.81308518580408e-28 NA NA NA hsa-miR-185-5p FZD4 0.482334746589337 3.68475879959415e-09 -2.45778080887863 8.2466362913083e-83 MirTarget -0.32822571943949 2.4240703164448e-08 NA NA NA hsa-miR-192-5p FZD4 1.33366224451777 9.5116159697107e-29 -2.45778080887863 8.2466362913083e-83 miRNAWalker2_validate;mirMAP -0.417317983267879 3.23659392050309e-28 NA NA NA hsa-miR-200b-3p FZD4 2.11744072703209 1.66710572104191e-43 -2.45778080887863 8.2466362913083e-83 mirMAP -0.443472478111004 1.62241648876776e-56 NA NA NA hsa-miR-200c-3p FZD4 2.07038651806183 6.84613386286599e-51 -2.45778080887863 8.2466362913083e-83 mirMAP -0.5394698778619 2.40222703670541e-71 NA NA NA hsa-miR-20a-5p FZD4 0.44979911120222 0.000602386964327228 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.349126822049724 3.50595644995987e-22 NA NA NA hsa-miR-21-5p FZD4 2.32007501846389 3.08394781855554e-137 -2.45778080887863 8.2466362913083e-83 mirMAP -0.617423104849022 4.14640575991911e-50 NA NA NA hsa-miR-212-3p FZD4 0.24081906669865 0.0571447155653209 -2.45778080887863 8.2466362913083e-83 mirMAP -0.106820495464605 0.0061660372674424 NA NA NA hsa-miR-25-3p FZD4 -0.00546790775985073 0.944061771389468 -2.45778080887863 8.2466362913083e-83 mirMAP -0.311311688515217 6.52111955612921e-07 NA NA NA hsa-miR-27a-3p FZD4 0.388496361379095 1.42373532086331e-05 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.332335163103274 6.55789467955252e-10 NA NA NA hsa-miR-301a-3p FZD4 1.32170168375632 2.12280368957514e-15 -2.45778080887863 8.2466362913083e-83 mirMAP -0.296293129313005 3.03122689456589e-26 NA NA NA hsa-miR-3065-3p FZD4 1.62787885002468 6.81477830005026e-19 -2.45778080887863 8.2466362913083e-83 mirMAP -0.21363490263864 4.05907439854592e-17 NA NA NA hsa-miR-3127-5p FZD4 0.903405128081314 1.1325923598273e-12 -2.45778080887863 8.2466362913083e-83 MirTarget -0.353612933288253 8.25127810305334e-22 NA NA NA hsa-miR-32-5p FZD4 1.38676603945192 2.29428299685976e-34 -2.45778080887863 8.2466362913083e-83 mirMAP -0.393954741435993 7.79828021744844e-23 NA NA NA hsa-miR-324-3p FZD4 0.404877731996915 0.000340036423920834 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.308721358633824 3.19173797166468e-13 NA NA NA hsa-miR-330-5p FZD4 0.626063225953928 3.42215028606779e-09 -2.45778080887863 8.2466362913083e-83 miRanda;miRNATAP -0.413410414565267 1.56474033349077e-20 NA NA NA hsa-miR-361-3p FZD4 -0.0370446538644886 0.624902392829872 -2.45778080887863 8.2466362913083e-83 MirTarget -0.210274672274026 0.00114713669929094 NA NA NA hsa-miR-429 FZD4 2.84108892259147 3.88520896426515e-64 -2.45778080887863 8.2466362913083e-83 mirMAP -0.419642690763874 1.62254290929758e-64 NA NA NA hsa-miR-454-3p FZD4 1.28177672191095 6.84024979484587e-21 -2.45778080887863 8.2466362913083e-83 mirMAP -0.33333483404347 1.07749136844395e-22 NA NA NA hsa-miR-455-3p FZD4 0.678392920628872 0.000327758844555877 -2.45778080887863 8.2466362913083e-83 mirMAP -0.187203964079631 1.23489599175754e-13 NA NA NA hsa-miR-484 FZD4 0.349444060004737 0.00154491249625173 -2.45778080887863 8.2466362913083e-83 PITA -0.212116451539721 1.28850151052031e-06 NA NA NA hsa-miR-576-5p FZD4 0.0649387707567879 0.588791966096287 -2.45778080887863 8.2466362913083e-83 mirMAP -0.1856965803836 4.20641790446917e-06 NA NA NA hsa-miR-582-5p FZD4 0.201134299470983 0.149482495292227 -2.45778080887863 8.2466362913083e-83 PITA;miRNATAP -0.128558705031842 0.000254827247268146 NA NA NA hsa-miR-590-3p FZD4 1.27438512890514 1.03164723481469e-23 -2.45778080887863 8.2466362913083e-83 miRanda;mirMAP;miRNATAP -0.406671608133116 3.85657572987706e-27 NA NA NA hsa-miR-590-5p FZD4 0.746515607868274 8.51300479640125e-09 -2.45778080887863 8.2466362913083e-83 mirMAP -0.331595766851545 7.67537979959466e-20 NA NA NA hsa-miR-629-3p FZD4 1.25035919247365 3.91361135469024e-14 -2.45778080887863 8.2466362913083e-83 miRNATAP -0.23213209252431 2.89292527551865e-15 NA NA NA hsa-miR-7-1-3p FZD4 0.686579567507582 1.20731554448806e-07 -2.45778080887863 8.2466362913083e-83 mirMAP -0.224934472313498 1.05455748906568e-09 NA NA NA hsa-miR-92a-3p FZD4 -0.342420481092807 0.000732275969501111 -2.45778080887863 8.2466362913083e-83 mirMAP -0.301979533216699 2.02325930056432e-10 NA NA NA hsa-miR-92b-3p FZD4 1.30248132773644 9.42428674470985e-25 -2.45778080887863 8.2466362913083e-83 mirMAP -0.348983639703719 6.88519966120482e-22 NA NA NA hsa-miR-98-5p FZD4 0.656336869298973 9.03113188590466e-15 -2.45778080887863 8.2466362913083e-83 MirTarget -0.528062971038367 1.52945921080448e-21 NA NA NA hsa-miR-194-5p FZD5 0.467781870340114 1.0386810618625e-07 -1.30576854554188 8.3393662705584e-32 miRNATAP -0.178831539257334 6.90395730167637e-05 NA NA NA hsa-miR-200a-3p FZD5 2.55218480823434 2.96135446816238e-51 -1.30576854554188 8.3393662705584e-32 mirMAP -0.193303591193815 3.54560151752924e-19 NA NA NA hsa-miR-342-3p FZD5 1.21944481975657 6.81914373001202e-19 -1.30576854554188 8.3393662705584e-32 PITA -0.25230820365646 7.06125013894829e-20 NA NA NA hsa-miR-450b-5p FZD5 0.781564228875267 3.90462514315383e-11 -1.30576854554188 8.3393662705584e-32 mirMAP -0.162494214108962 8.75558752610779e-07 NA NA NA hsa-miR-493-5p FZD5 1.25321217062116 2.58094342947875e-18 -1.30576854554188 8.3393662705584e-32 mirMAP -0.148378073973601 4.37435544088392e-08 NA NA NA hsa-miR-101-3p FZD6 -0.126035286271986 0.145997832808138 -0.245458286479777 0.0729026487995083 miRNAWalker2_validate;MirTarget -0.18427726420101 0.00071074749259132 NA NA NA hsa-miR-194-5p FZD6 0.467781870340114 1.0386810618625e-07 -0.245458286479777 0.0729026487995083 MirTarget -0.1574113672057 0.003131819177647 NA NA NA hsa-miR-192-5p FZD7 1.33366224451777 9.5116159697107e-29 -1.37883556350474 1.57806088531265e-27 miRNAWalker2_validate -0.161936601307415 7.47545781365299e-06 NA NA NA hsa-miR-338-3p FZD7 0.0799903526884966 0.575137668326679 -1.37883556350474 1.57806088531265e-27 miRanda -0.141146838960966 7.12302368603286e-06 NA NA NA hsa-miR-429 FZD7 2.84108892259147 3.88520896426515e-64 -1.37883556350474 1.57806088531265e-27 miRanda;miRNATAP -0.118345789299754 1.70567166199748e-06 NA NA NA hsa-miR-590-3p FZD7 1.27438512890514 1.03164723481469e-23 -1.37883556350474 1.57806088531265e-27 miRanda -0.113468728152917 0.0016315686222763 NA NA NA hsa-miR-324-5p FZD8 0.211552647440779 0.139408130311654 -0.451402348278936 0.00210719128371962 miRanda -0.112580820578128 0.00139833151556216 NA NA NA hsa-miR-590-3p FZD8 1.27438512890514 1.03164723481469e-23 -0.451402348278936 0.00210719128371962 miRanda -0.187080083941158 3.36973671342903e-06 NA NA NA hsa-miR-7-1-3p FZD8 0.686579567507582 1.20731554448806e-07 -0.451402348278936 0.00210719128371962 MirTarget -0.285864089758394 6.15672183615667e-14 NA NA NA hsa-miR-99b-5p FZD8 0.286053025104474 0.0059164652978285 -0.451402348278936 0.00210719128371962 MirTarget -0.27167361740119 1.84979575053296e-08 NA NA NA hsa-miR-10b-5p FZR1 -2.10996264627796 7.36811595736367e-72 0.573165619167388 5.17199488609469e-18 mirMAP -0.151118311330591 1.15407415870322e-17 NA NA NA hsa-miR-335-5p G6PD -2.61355235628987 2.6462884165886e-51 0.739016033128313 4.04118035807615e-14 miRNAWalker2_validate -0.101443020499323 3.05363958817843e-08 NA NA NA hsa-miR-141-3p GAB1 2.99777540204168 1.26370498493024e-78 -0.692166188366933 9.18798859765721e-16 MirTarget;TargetScan -0.120372236176324 8.11764203508008e-13 NA NA NA hsa-miR-429 GAB1 2.84108892259147 3.88520896426515e-64 -0.692166188366933 9.18798859765721e-16 miRanda;miRNATAP -0.114062148935215 3.49638206904719e-12 NA NA NA hsa-miR-429 GAB2 2.84108892259147 3.88520896426515e-64 -0.761937427307663 6.84268214136315e-10 miRNATAP -0.100535333411 1.97391196154341e-05 NA NA NA hsa-miR-429 GABARAPL1 2.84108892259147 3.88520896426515e-64 -1.495397581069 1.21014793657311e-69 miRanda;miRNATAP -0.237549492524662 9.45055201687522e-47 NA NA NA hsa-miR-139-5p GABBR2 -3.25846663863766 2.62018989415003e-112 0.0599237719685148 0.858856416372801 PITA;miRanda;miRNATAP -0.176130005773324 0.0111072254747395 NA NA NA hsa-miR-139-5p GABPB1 -3.25846663863766 2.62018989415003e-112 0.368520217107261 7.92352317529943e-13 miRanda -0.101784949621671 1.78578008368789e-22 NA NA NA hsa-miR-429 GABRA2 2.84108892259147 3.88520896426515e-64 -3.42586303563526 6.03733090485765e-37 miRanda -0.536289174393058 6.1378263558752e-25 NA NA NA hsa-miR-139-5p GABRA3 -3.25846663863766 2.62018989415003e-112 1.28107431396582 1.68674844080533e-05 miRanda -0.26271476836661 1.88080265698053e-05 NA NA NA hsa-miR-200b-3p GABRB3 2.11744072703209 1.66710572104191e-43 -1.54942182708902 1.18499394645321e-06 TargetScan;mirMAP -0.281534254670845 3.37682375365578e-05 NA NA NA hsa-miR-200c-3p GABRB3 2.07038651806183 6.84613386286599e-51 -1.54942182708902 1.18499394645321e-06 mirMAP -0.366813338721231 8.51819965183799e-07 NA NA NA hsa-miR-429 GABRB3 2.84108892259147 3.88520896426515e-64 -1.54942182708902 1.18499394645321e-06 PITA;miRanda;mirMAP -0.334694339510525 2.98621721907639e-08 NA NA NA hsa-miR-335-5p GABRQ -2.61355235628987 2.6462884165886e-51 1.30199369886026 2.11205346117266e-06 miRNAWalker2_validate -0.253640105522375 6.77578231841997e-07 NA NA NA hsa-miR-486-5p GAD1 -3.87258704301474 1.22658629378451e-80 1.22643355770781 1.99499140758944e-05 miRanda -0.250148891838185 9.37539572516998e-09 NA NA NA hsa-miR-429 GAL3ST1 2.84108892259147 3.88520896426515e-64 -1.67367106871635 1.48811476434126e-15 miRanda;miRNATAP -0.1203803453585 0.00291731325128483 NA NA NA hsa-miR-335-5p GAL3ST4 -2.61355235628987 2.6462884165886e-51 0.594138336573289 7.824274187403e-12 miRNAWalker2_validate -0.122616726118839 2.49706770165375e-14 NA NA NA hsa-miR-429 GALNT10 2.84108892259147 3.88520896426515e-64 0.227833941975381 0.0563309072028891 miRanda -0.106916804630346 2.04070345713091e-06 NA NA NA hsa-miR-21-5p GALNT12 2.32007501846389 3.08394781855554e-137 -1.36733884812324 2.21443071217223e-17 MirTarget -0.161602797404253 0.00161251314485952 NA NA NA hsa-miR-429 GALNT12 2.84108892259147 3.88520896426515e-64 -1.36733884812324 2.21443071217223e-17 miRanda -0.254397331267564 9.35548963894095e-17 NA NA NA hsa-miR-335-5p GALNT5 -2.61355235628987 2.6462884165886e-51 0.850999438268856 0.000296150278506579 miRNAWalker2_validate -0.16832145423576 0.000118971616971113 NA NA NA hsa-miR-139-5p GALNT7 -3.25846663863766 2.62018989415003e-112 1.0914967844721 3.39918948596231e-14 MirTarget;PITA;miRanda;miRNATAP -0.140682182189771 2.70978177852261e-06 NA NA NA hsa-miR-375 GAP43 2.09893673049766 1.68351780396203e-16 -0.252869077259157 0.152628613137104 miRanda -0.127967453314962 3.27677582590075e-08 NA NA NA hsa-miR-429 GAP43 2.84108892259147 3.88520896426515e-64 -0.252869077259157 0.152628613137104 miRNATAP -0.193133659727413 6.1461023946192e-09 NA NA NA hsa-miR-96-5p GAP43 3.24596558166606 1.92296159041707e-98 -0.252869077259157 0.152628613137104 MirTarget;TargetScan;miRNATAP -0.196371238475191 1.52145905983502e-08 NA NA NA hsa-miR-452-5p GARNL3 -2.48486455572568 1.24430987974325e-33 -0.542780498898654 4.75348259989693e-06 MirTarget -0.107368358553745 1.38035080469192e-08 NA NA NA hsa-miR-183-5p GAS1 2.95681814393872 1.09965777344285e-92 -1.65871668287995 1.94471293963436e-27 miRNAWalker2_validate -0.419009244085051 8.34367517774905e-40 NA NA NA hsa-miR-429 GAS2 2.84108892259147 3.88520896426515e-64 -2.04350176248019 3.32092310032779e-36 miRanda -0.20460475978396 1.44249534621512e-10 NA NA NA hsa-miR-182-5p GAS7 2.36408084103818 2.60011457600281e-72 -1.14456976255473 3.24757711318389e-18 mirMAP -0.295214863838364 3.54648365842449e-21 NA NA NA hsa-miR-200a-5p GAS7 2.58844508672328 1.79650654234569e-56 -1.14456976255473 3.24757711318389e-18 mirMAP -0.24342730596673 1.98565530787619e-21 NA NA NA hsa-miR-375 GAS7 2.09893673049766 1.68351780396203e-16 -1.14456976255473 3.24757711318389e-18 mirMAP -0.120721778233954 5.4314229314805e-12 NA NA NA hsa-miR-429 GAS7 2.84108892259147 3.88520896426515e-64 -1.14456976255473 3.24757711318389e-18 miRNATAP -0.293133466912333 4.21983105835548e-33 NA NA NA hsa-miR-96-5p GAS7 3.24596558166606 1.92296159041707e-98 -1.14456976255473 3.24757711318389e-18 mirMAP -0.337743164785272 9.93402134118862e-41 NA NA NA hsa-miR-200b-3p GATA2 2.11744072703209 1.66710572104191e-43 -0.140432100799638 0.470531651480733 TargetScan -0.154914225633704 0.000168590571516974 NA NA NA hsa-miR-200c-3p GATA2 2.07038651806183 6.84613386286599e-51 -0.140432100799638 0.470531651480733 miRNATAP -0.162448976897229 0.00033567348174011 NA NA NA hsa-miR-429 GATA2 2.84108892259147 3.88520896426515e-64 -0.140432100799638 0.470531651480733 PITA;miRanda;miRNATAP -0.1515739525595 3.69928806961774e-05 NA NA NA hsa-miR-139-5p GATA3 -3.25846663863766 2.62018989415003e-112 1.5576496597582 2.58751948867418e-11 miRanda -0.163953271104185 0.000749297599580816 NA NA NA hsa-miR-335-5p GATA5 -2.61355235628987 2.6462884165886e-51 1.29302307674066 0.000147351675708818 miRNAWalker2_validate -0.128289337228262 0.0436650105454609 NA NA NA hsa-miR-141-3p GATA6 2.99777540204168 1.26370498493024e-78 -0.699851594860171 1.92456260924552e-07 TargetScan;miRNATAP -0.134449805077958 2.77866092858394e-07 NA NA NA hsa-miR-183-5p GATA6 2.95681814393872 1.09965777344285e-92 -0.699851594860171 1.92456260924552e-07 miRNAWalker2_validate -0.154395838900064 5.1082133947398e-08 NA NA NA hsa-miR-200a-3p GATA6 2.55218480823434 2.96135446816238e-51 -0.699851594860171 1.92456260924552e-07 miRNAWalker2_validate;miRNATAP -0.127017900812787 7.63206405009383e-07 NA NA NA hsa-miR-375 GATA6 2.09893673049766 1.68351780396203e-16 -0.699851594860171 1.92456260924552e-07 miRNAWalker2_validate;miRanda;miRNATAP -0.165989908192913 1.6229185846306e-21 NA NA NA hsa-miR-96-5p GATA6 3.24596558166606 1.92296159041707e-98 -0.699851594860171 1.92456260924552e-07 TargetScan -0.163075806013056 7.86969255059317e-10 NA NA NA hsa-miR-145-5p GATC -2.62703571936687 7.64402900188551e-88 0.310045268767208 0.000461165940709552 MirTarget -0.104974833197868 3.0068913737638e-07 NA NA NA hsa-miR-429 GBE1 2.84108892259147 3.88520896426515e-64 -1.29867268854739 1.30922018609459e-45 miRanda -0.226474617865547 3.62668603746319e-38 NA NA NA hsa-miR-200b-3p GBP4 2.11744072703209 1.66710572104191e-43 -0.502395556019755 0.0012264052654199 mirMAP -0.159450999465721 1.24307304900707e-06 NA NA NA hsa-miR-139-5p GBP5 -3.25846663863766 2.62018989415003e-112 1.4487955399817 1.09485525316246e-11 miRanda -0.30766764395582 2.51285365403617e-12 NA NA NA hsa-miR-139-5p GCH1 -3.25846663863766 2.62018989415003e-112 0.663347055632082 7.01088046625238e-12 miRanda -0.12786956951908 1.50246411146438e-10 NA NA NA hsa-miR-335-5p GCNT3 -2.61355235628987 2.6462884165886e-51 1.32177145177405 2.12175103344471e-07 miRNAWalker2_validate -0.203059245141923 1.93449709963955e-05 NA NA NA hsa-miR-141-3p GCNT4 2.99777540204168 1.26370498493024e-78 -2.07187899362037 1.85247504296876e-28 TargetScan -0.364846855091179 2.77113107228307e-23 NA NA NA hsa-miR-182-5p GCNT4 2.36408084103818 2.60011457600281e-72 -2.07187899362037 1.85247504296876e-28 MirTarget -0.333503181003506 2.56636228625258e-13 NA NA NA hsa-miR-429 GCNT4 2.84108892259147 3.88520896426515e-64 -2.07187899362037 1.85247504296876e-28 miRanda -0.356955857234418 1.79990143084513e-23 NA NA NA hsa-miR-96-5p GCNT4 3.24596558166606 1.92296159041707e-98 -2.07187899362037 1.85247504296876e-28 TargetScan -0.390182190540265 1.00302162191375e-25 NA NA NA hsa-miR-21-3p GCOM1 2.17476065946878 5.15299442583591e-75 -3.40588639306685 1.18235039087866e-71 MirTarget -0.642168445765633 3.21999138012061e-34 NA NA NA hsa-miR-429 GCOM1 2.84108892259147 3.88520896426515e-64 -3.40588639306685 1.18235039087866e-71 miRanda -0.415572929907922 1.53362015254347e-27 NA NA NA hsa-miR-378a-5p GDE1 -2.43173551693523 1.44932837789175e-68 0.345346647212217 2.60816934857472e-08 miRNAWalker2_validate -0.12181972085905 1.39458281086098e-18 NA NA NA hsa-miR-335-5p GDF15 -2.61355235628987 2.6462884165886e-51 1.71442834502874 8.07680393455908e-13 miRNAWalker2_validate -0.125173271181598 0.00554643596106704 NA NA NA hsa-miR-141-3p GDF6 2.99777540204168 1.26370498493024e-78 -0.388623710302829 0.0268119680640758 TargetScan -0.245691412390661 3.02382137529226e-13 NA NA NA hsa-miR-141-5p GDF6 2.38411349683216 4.56310582620282e-58 -0.388623710302829 0.0268119680640758 mirMAP -0.215895062193741 8.08164935094237e-09 NA NA NA hsa-miR-200b-3p GDF6 2.11744072703209 1.66710572104191e-43 -0.388623710302829 0.0268119680640758 TargetScan -0.235189970868671 1.83473115362667e-10 NA NA NA hsa-miR-429 GDF6 2.84108892259147 3.88520896426515e-64 -0.388623710302829 0.0268119680640758 PITA;miRanda;miRNATAP -0.195401437731195 3.19568062685289e-09 NA NA NA hsa-miR-139-5p GDPD1 -3.25846663863766 2.62018989415003e-112 0.515452946339576 0.000266722408233664 miRanda -0.10361002854512 0.000379085395644394 NA NA NA hsa-miR-429 GDPD5 2.84108892259147 3.88520896426515e-64 -1.42259476027658 2.71926623796958e-27 miRNATAP -0.150096556562522 4.16618827473404e-09 NA NA NA hsa-miR-141-3p GEM 2.99777540204168 1.26370498493024e-78 -1.31064474948309 3.35918949026588e-21 MirTarget -0.348552712353379 5.36878261091719e-40 NA NA NA hsa-miR-200a-3p GEM 2.55218480823434 2.96135446816238e-51 -1.31064474948309 3.35918949026588e-21 MirTarget -0.272868820275543 3.85481987191298e-25 NA NA NA hsa-miR-200b-3p GEM 2.11744072703209 1.66710572104191e-43 -1.31064474948309 3.35918949026588e-21 MirTarget -0.252352371736365 1.51025792341624e-17 NA NA NA hsa-miR-200c-3p GEM 2.07038651806183 6.84613386286599e-51 -1.31064474948309 3.35918949026588e-21 MirTarget;miRNATAP -0.335050212119271 2.44070410189031e-25 NA NA NA hsa-miR-429 GEM 2.84108892259147 3.88520896426515e-64 -1.31064474948309 3.35918949026588e-21 MirTarget;PITA;miRanda;miRNATAP -0.275192747833231 6.37478984026231e-26 NA NA NA hsa-miR-429 GFAP 2.84108892259147 3.88520896426515e-64 -3.85461778915584 7.20332920996276e-45 miRanda -0.466007995868831 5.37612886192833e-18 NA NA NA hsa-miR-182-5p GFOD1 2.36408084103818 2.60011457600281e-72 -1.09275877413555 6.11609807215772e-20 mirMAP -0.23036726184721 9.38978689654259e-16 NA NA NA hsa-miR-21-5p GFOD1 2.32007501846389 3.08394781855554e-137 -1.09275877413555 6.11609807215772e-20 mirMAP -0.235487765626004 4.61516332759543e-10 NA NA NA hsa-miR-96-5p GFOD1 3.24596558166606 1.92296159041707e-98 -1.09275877413555 6.11609807215772e-20 mirMAP -0.199192803152529 4.98342730481405e-17 NA NA NA hsa-miR-21-5p GFPT1 2.32007501846389 3.08394781855554e-137 0.207724170922615 0.0145042266616425 mirMAP -0.142526180324638 6.09235557381341e-08 NA NA NA hsa-miR-141-3p GFRA1 2.99777540204168 1.26370498493024e-78 -0.692412159332901 0.064695425447951 mirMAP -0.167089725636287 0.0219950061737178 NA NA NA hsa-miR-429 GFRA1 2.84108892259147 3.88520896426515e-64 -0.692412159332901 0.064695425447951 mirMAP;miRNATAP -0.149538159677534 0.0354500320927691 NA NA NA hsa-miR-452-5p GFRA1 -2.48486455572568 1.24430987974325e-33 -0.692412159332901 0.064695425447951 MirTarget -0.599828090586184 6.96296920386979e-25 NA NA NA hsa-miR-511-5p GFRA1 -2.27545475897362 3.84085514050558e-36 -0.692412159332901 0.064695425447951 MirTarget -0.208975975273561 0.00219600886737392 NA NA NA hsa-miR-141-3p GFRA2 2.99777540204168 1.26370498493024e-78 -2.62832301970864 3.54115116223358e-39 mirMAP -0.574806492171226 2.21900306521903e-50 NA NA NA hsa-miR-200a-3p GFRA2 2.55218480823434 2.96135446816238e-51 -2.62832301970864 3.54115116223358e-39 mirMAP -0.438591314587542 1.35604664373649e-29 NA NA NA hsa-miR-21-3p GFRA2 2.17476065946878 5.15299442583591e-75 -2.62832301970864 3.54115116223358e-39 MirTarget -0.535870828627447 3.5780290756117e-23 NA NA NA hsa-miR-486-5p GGCT -3.87258704301474 1.22658629378451e-80 1.26827366395634 1.47023374799991e-44 miRanda -0.168048055094835 2.50762310895611e-33 NA NA NA hsa-miR-429 GHR 2.84108892259147 3.88520896426515e-64 -3.36237154973502 5.01584120795748e-76 miRanda;miRNATAP -0.565426163436487 1.88289719909835e-57 NA NA NA hsa-miR-511-5p GIGYF1 -2.27545475897362 3.84085514050558e-36 0.125800039901468 0.125564353932774 MirTarget -0.104453000752681 1.41011536483143e-12 NA NA NA hsa-miR-141-5p GIMAP1 2.38411349683216 4.56310582620282e-58 -1.14090140112924 1.29318417460205e-16 MirTarget -0.312688721938568 1.17856993311629e-26 NA NA NA hsa-miR-182-5p GIMAP1 2.36408084103818 2.60011457600281e-72 -1.14090140112924 1.29318417460205e-16 MirTarget -0.31782734802151 2.13513263153298e-22 NA NA NA hsa-miR-200a-3p GIMAP1 2.55218480823434 2.96135446816238e-51 -1.14090140112924 1.29318417460205e-16 mirMAP -0.19553007276345 1.40211663424468e-13 NA NA NA hsa-miR-452-5p GIN1 -2.48486455572568 1.24430987974325e-33 -0.186601188920119 0.00320188876226119 MirTarget -0.118894938831521 1.55621342881188e-34 NA NA NA hsa-miR-139-5p GINS1 -3.25846663863766 2.62018989415003e-112 2.30840426465024 1.57569372974694e-71 miRanda -0.473610739388037 8.89129805456437e-71 NA NA NA hsa-miR-486-5p GINS1 -3.87258704301474 1.22658629378451e-80 2.30840426465024 1.57569372974694e-71 miRanda -0.253116135462166 9.75720876346779e-35 NA NA NA hsa-miR-182-5p GIPC3 2.36408084103818 2.60011457600281e-72 -0.351339987058582 0.000104100939716629 mirMAP -0.132091312410301 7.23111639796654e-10 NA NA NA hsa-miR-200c-3p GIT2 2.07038651806183 6.84613386286599e-51 -0.336020253372316 1.73645416728317e-15 MirTarget;miRNATAP -0.100168641242341 4.55546604514242e-25 NA NA NA hsa-miR-429 GJA1 2.84108892259147 3.88520896426515e-64 -0.194519922996644 0.269525778730357 miRanda;miRNATAP -0.13974473350262 2.64824504894479e-05 NA NA NA hsa-miR-145-5p GJA3 -2.62703571936687 7.64402900188551e-88 2.03278137397596 1.4130486243529e-24 MirTarget -0.256395241360959 5.73713435788977e-08 NA NA NA hsa-miR-429 GJA5 2.84108892259147 3.88520896426515e-64 -0.575223257663598 1.04231368174895e-06 miRanda -0.207671826674479 2.56288432173679e-21 NA NA NA hsa-miR-335-5p GJB2 -2.61355235628987 2.6462884165886e-51 4.21763130547585 1.50426225073851e-68 miRNAWalker2_validate -0.546020159230628 4.23592116116774e-31 NA NA NA hsa-miR-335-5p GJB4 -2.61355235628987 2.6462884165886e-51 -0.0487751016182094 0.84064699612715 miRNAWalker2_validate -0.198952837579176 9.29933027390865e-06 NA NA NA hsa-miR-335-5p GJB5 -2.61355235628987 2.6462884165886e-51 -0.493228897946262 0.0847347792378887 miRNAWalker2_validate -0.251298406331041 2.06610769461138e-06 NA NA NA hsa-miR-335-5p GJB6 -2.61355235628987 2.6462884165886e-51 1.20669007089706 6.14214925918107e-05 miRNAWalker2_validate -0.308298380629778 3.29498227219174e-08 NA NA NA hsa-miR-141-3p GJC1 2.99777540204168 1.26370498493024e-78 -0.204948069311232 0.0558702919863598 MirTarget;TargetScan;miRNATAP -0.127727914623235 6.12697367691871e-10 NA NA NA hsa-miR-182-5p GJC1 2.36408084103818 2.60011457600281e-72 -0.204948069311232 0.0558702919863598 mirMAP -0.126199758597978 6.79937558449417e-07 NA NA NA hsa-miR-200a-3p GJC1 2.55218480823434 2.96135446816238e-51 -0.204948069311232 0.0558702919863598 MirTarget;miRNATAP -0.145199560968071 6.13400378527903e-13 NA NA NA hsa-miR-200b-3p GJC1 2.11744072703209 1.66710572104191e-43 -0.204948069311232 0.0558702919863598 MirTarget;TargetScan -0.176114849877955 3.47662579134373e-15 NA NA NA hsa-miR-200c-3p GJC1 2.07038651806183 6.84613386286599e-51 -0.204948069311232 0.0558702919863598 MirTarget;miRNATAP -0.177640718193948 6.03263964972077e-13 NA NA NA hsa-miR-429 GJC1 2.84108892259147 3.88520896426515e-64 -0.204948069311232 0.0558702919863598 MirTarget;miRanda;miRNATAP -0.125826160050395 3.93293803567993e-10 NA NA NA hsa-miR-10b-5p GK -2.10996264627796 7.36811595736367e-72 1.10621967129951 4.4935017416436e-30 miRNAWalker2_validate -0.206306580039356 5.72661032314055e-15 NA NA NA hsa-miR-21-5p GLCCI1 2.32007501846389 3.08394781855554e-137 -0.101140566015224 0.336314475901998 miRNAWalker2_validate;MirTarget;miRNATAP -0.138403185382784 2.25008985423918e-05 NA NA NA hsa-miR-452-5p GLCCI1 -2.48486455572568 1.24430987974325e-33 -0.101140566015224 0.336314475901998 miRNATAP -0.102483641213085 7.39710494738802e-10 NA NA NA hsa-miR-141-3p GLDN 2.99777540204168 1.26370498493024e-78 -2.61650983542568 1.11303088078107e-39 MirTarget -0.486032533124165 6.06583711765146e-36 NA NA NA hsa-miR-200a-3p GLDN 2.55218480823434 2.96135446816238e-51 -2.61650983542568 1.11303088078107e-39 MirTarget -0.424820200840999 2.45625499473469e-28 NA NA NA hsa-miR-200a-5p GLDN 2.58844508672328 1.79650654234569e-56 -2.61650983542568 1.11303088078107e-39 mirMAP -0.501909731374884 4.42914847166315e-38 NA NA NA hsa-miR-429 GLDN 2.84108892259147 3.88520896426515e-64 -2.61650983542568 1.11303088078107e-39 miRanda -0.448980215896027 3.58006360548267e-32 NA NA NA hsa-miR-200b-3p GLG1 2.11744072703209 1.66710572104191e-43 -0.496855757011849 1.36067250511171e-17 TargetScan -0.11154435989524 1.1641673862493e-19 NA NA NA hsa-miR-21-5p GLG1 2.32007501846389 3.08394781855554e-137 -0.496855757011849 1.36067250511171e-17 miRNAWalker2_validate -0.103595106102721 1.60417528195648e-08 NA NA NA hsa-miR-141-3p GLI2 2.99777540204168 1.26370498493024e-78 -0.809812833399723 1.77977002621718e-08 MirTarget -0.333509982639127 5.41463993853588e-35 NA NA NA hsa-miR-182-5p GLI2 2.36408084103818 2.60011457600281e-72 -0.809812833399723 1.77977002621718e-08 MirTarget -0.291684858992199 7.42083673403218e-18 NA NA NA hsa-miR-200a-3p GLI2 2.55218480823434 2.96135446816238e-51 -0.809812833399723 1.77977002621718e-08 MirTarget -0.276570337072336 7.57698921345758e-25 NA NA NA hsa-miR-429 GLI3 2.84108892259147 3.88520896426515e-64 -0.342784298215017 0.0107211036407835 PITA;miRanda;miRNATAP -0.124840907679215 8.40782441410536e-07 NA NA NA hsa-miR-429 GLIPR2 2.84108892259147 3.88520896426515e-64 -0.653646954402138 1.67132321944002e-07 miRanda -0.107011933663223 6.54622278141142e-06 NA NA NA hsa-miR-139-5p GLO1 -3.25846663863766 2.62018989415003e-112 0.626572279811513 1.26285875046756e-18 miRanda -0.162284500492135 2.50443577315789e-29 NA NA NA hsa-miR-429 GLRA3 2.84108892259147 3.88520896426515e-64 -2.80450626570897 2.23475046701745e-11 miRanda;mirMAP -0.241391358213638 0.00267520259520109 NA NA NA hsa-miR-429 GLYCTK 2.84108892259147 3.88520896426515e-64 -0.758165288340076 4.48728481736755e-13 miRNATAP -0.139955757353447 1.87074267962203e-12 NA NA NA hsa-miR-335-5p GMPPB -2.61355235628987 2.6462884165886e-51 0.908612851493226 8.75105049488875e-32 mirMAP -0.149050099427669 1.04935825408742e-24 NA NA NA hsa-miR-337-3p GMPPB -2.14274617598363 2.70942896809734e-43 0.908612851493226 8.75105049488875e-32 mirMAP -0.14386773785734 2.6697629174197e-18 NA NA NA hsa-miR-378a-5p GMPPB -2.43173551693523 1.44932837789175e-68 0.908612851493226 8.75105049488875e-32 mirMAP -0.171734700431875 4.11564544808765e-22 NA NA NA hsa-miR-141-3p GNAI1 2.99777540204168 1.26370498493024e-78 -2.59725421035606 4.41129786088359e-78 TargetScan -0.408299073467948 7.17887803089354e-48 NA NA NA hsa-miR-429 GNAI1 2.84108892259147 3.88520896426515e-64 -2.59725421035606 4.41129786088359e-78 miRanda -0.378231213082703 6.73121398065079e-43 NA NA NA hsa-miR-141-3p GNAQ 2.99777540204168 1.26370498493024e-78 -0.708451286886118 2.10962512697924e-15 MirTarget -0.116529482917389 2.48345872468237e-11 NA NA NA hsa-miR-200a-3p GNAQ 2.55218480823434 2.96135446816238e-51 -0.708451286886118 2.10962512697924e-15 MirTarget -0.111393679222787 8.1020608530641e-11 NA NA NA hsa-miR-200b-3p GNAQ 2.11744072703209 1.66710572104191e-43 -0.708451286886118 2.10962512697924e-15 TargetScan -0.11430812398522 2.16983122874448e-09 NA NA NA hsa-miR-21-5p GNAQ 2.32007501846389 3.08394781855554e-137 -0.708451286886118 2.10962512697924e-15 miRNAWalker2_validate -0.249840104809404 1.86559916333158e-19 NA NA NA hsa-miR-429 GNAQ 2.84108892259147 3.88520896426515e-64 -0.708451286886118 2.10962512697924e-15 MirTarget -0.116723996917453 6.58930185883099e-12 NA NA NA hsa-miR-21-3p GNAZ 2.17476065946878 5.15299442583591e-75 -0.947628855344322 4.27683434810632e-14 MirTarget -0.196963625192341 3.26743686355557e-09 NA NA NA hsa-miR-335-5p GNB1L -2.61355235628987 2.6462884165886e-51 1.00615236343476 3.17945542450536e-17 mirMAP -0.185951362977231 5.0896510245941e-17 NA NA NA hsa-miR-141-3p GNE 2.99777540204168 1.26370498493024e-78 -1.03696689854156 5.56635729181646e-30 MirTarget -0.14500000506443 1.01694996635721e-15 NA NA NA hsa-miR-200a-3p GNE 2.55218480823434 2.96135446816238e-51 -1.03696689854156 5.56635729181646e-30 MirTarget -0.127198364193185 8.84895824382958e-13 NA NA NA hsa-miR-21-5p GNE 2.32007501846389 3.08394781855554e-137 -1.03696689854156 5.56635729181646e-30 miRNAWalker2_validate -0.361917634353926 7.35979773519695e-38 NA NA NA hsa-miR-96-5p GNE 3.24596558166606 1.92296159041707e-98 -1.03696689854156 5.56635729181646e-30 MirTarget;TargetScan -0.158840168137051 4.31680035872518e-18 NA NA NA hsa-miR-429 GNG12 2.84108892259147 3.88520896426515e-64 -1.00662202078145 1.13075382846906e-21 miRanda -0.170551562257512 1.90032220822832e-17 NA NA NA hsa-miR-96-5p GNG12 3.24596558166606 1.92296159041707e-98 -1.00662202078145 1.13075382846906e-21 TargetScan -0.177675699622518 2.20766570176543e-17 NA NA NA hsa-miR-511-5p GNG13 -2.27545475897362 3.84085514050558e-36 3.60156617640628 6.90742745616058e-33 MirTarget -0.512118109882972 5.35501018269789e-20 NA NA NA hsa-miR-21-5p GNG2 2.32007501846389 3.08394781855554e-137 -1.9182405505051 4.75840171347434e-62 miRNATAP -0.40885794761468 1.88540041022037e-27 NA NA NA hsa-miR-429 GNG2 2.84108892259147 3.88520896426515e-64 -1.9182405505051 4.75840171347434e-62 miRanda;miRNATAP -0.366896431796571 2.59270002688012e-63 NA NA NA hsa-miR-141-3p GNG7 2.99777540204168 1.26370498493024e-78 -1.27893544175867 1.22567787829192e-21 MirTarget;TargetScan;miRNATAP -0.160816727393679 1.22991601143051e-09 NA NA NA hsa-miR-182-5p GNG7 2.36408084103818 2.60011457600281e-72 -1.27893544175867 1.22567787829192e-21 mirMAP -0.192436587268947 3.0582156776103e-09 NA NA NA hsa-miR-96-5p GNG7 3.24596558166606 1.92296159041707e-98 -1.27893544175867 1.22567787829192e-21 mirMAP -0.189536520051665 1.57219350207875e-12 NA NA NA hsa-miR-429 GNS 2.84108892259147 3.88520896426515e-64 -0.509592147216135 7.51158962279138e-14 miRanda -0.147115427882678 1.77755587255568e-31 NA NA NA hsa-miR-21-5p GOLGA4 2.32007501846389 3.08394781855554e-137 -0.354253862700929 1.49977523684552e-05 miRNAWalker2_validate -0.222012915700454 8.41375733993621e-19 NA NA NA hsa-miR-200b-3p GOLIM4 2.11744072703209 1.66710572104191e-43 -0.506535769934108 0.00010441305803676 TargetScan -0.195075752356037 1.16251820238862e-12 NA NA NA hsa-miR-145-5p GOLM1 -2.62703571936687 7.64402900188551e-88 1.26468872915984 1.10705867867101e-25 miRNAWalker2_validate;MirTarget -0.219019492251804 1.50214750904505e-14 NA NA NA hsa-miR-139-5p GOT2 -3.25846663863766 2.62018989415003e-112 0.746815625185166 7.41910081877425e-21 PITA;miRanda -0.154905347135813 3.7199845100667e-21 NA NA NA hsa-miR-141-3p GPAM 2.99777540204168 1.26370498493024e-78 -3.76340793083535 6.90651818189149e-141 MirTarget -0.595191637115214 3.19635951075136e-81 NA NA NA hsa-miR-182-5p GPAM 2.36408084103818 2.60011457600281e-72 -3.76340793083535 6.90651818189149e-141 mirMAP -0.549841577288505 1.17038066329194e-42 NA NA NA hsa-miR-183-5p GPAM 2.95681814393872 1.09965777344285e-92 -3.76340793083535 6.90651818189149e-141 MirTarget -0.560665813607665 2.20624543424357e-58 NA NA NA hsa-miR-200a-3p GPAM 2.55218480823434 2.96135446816238e-51 -3.76340793083535 6.90651818189149e-141 MirTarget -0.50035434320779 1.43449916572614e-56 NA NA NA hsa-miR-21-5p GPAM 2.32007501846389 3.08394781855554e-137 -3.76340793083535 6.90651818189149e-141 miRNAWalker2_validate;mirMAP -1.00114277511959 1.84469265987155e-91 NA NA NA hsa-miR-139-5p GPATCH2 -3.25846663863766 2.62018989415003e-112 0.814374986525279 1.4071495678159e-20 miRanda -0.140715499017628 9.80940730618731e-15 NA NA NA hsa-miR-182-5p GPC3 2.36408084103818 2.60011457600281e-72 -3.69284296262624 1.43050272445074e-55 miRNATAP -0.558572748994959 1.75534158299999e-21 NA NA NA hsa-miR-96-5p GPC3 3.24596558166606 1.92296159041707e-98 -3.69284296262624 1.43050272445074e-55 MirTarget;TargetScan;miRNATAP -0.59765475716044 6.54860672352359e-36 NA NA NA hsa-miR-141-3p GPC6 2.99777540204168 1.26370498493024e-78 -0.885655085868431 1.40422629455049e-06 TargetScan -0.364331309987999 1.41757400628427e-25 NA NA NA hsa-miR-200b-3p GPC6 2.11744072703209 1.66710572104191e-43 -0.885655085868431 1.40422629455049e-06 TargetScan -0.376990233935591 5.14299665466106e-23 NA NA NA hsa-miR-429 GPC6 2.84108892259147 3.88520896426515e-64 -0.885655085868431 1.40422629455049e-06 miRanda -0.261652024531722 3.21795083564754e-14 NA NA NA hsa-miR-183-5p GPCPD1 2.95681814393872 1.09965777344285e-92 -0.755743323923126 1.58505545075048e-17 MirTarget -0.126309013973809 2.09278139670238e-11 NA NA NA hsa-miR-429 GPCPD1 2.84108892259147 3.88520896426515e-64 -0.755743323923126 1.58505545075048e-17 miRanda;miRNATAP -0.112243223552432 3.55131237240746e-11 NA NA NA hsa-miR-141-3p GPD1 2.99777540204168 1.26370498493024e-78 -6.26299533147511 8.19883574270344e-72 TargetScan -1.01936339700388 8.35634193156972e-48 NA NA NA hsa-miR-429 GPD1 2.84108892259147 3.88520896426515e-64 -6.26299533147511 8.19883574270344e-72 miRNATAP -0.859593338707199 4.11069875228802e-35 NA NA NA hsa-miR-21-5p GPD1L 2.32007501846389 3.08394781855554e-137 -0.937731331711184 4.68433443761075e-16 miRNAWalker2_validate -0.34071263566115 1.68083569788086e-21 NA NA NA hsa-miR-96-5p GPHN 3.24596558166606 1.92296159041707e-98 -0.557554725890697 6.83461281403282e-08 TargetScan;miRNATAP -0.104306253809434 3.46871062230973e-07 NA NA NA hsa-miR-429 GPLD1 2.84108892259147 3.88520896426515e-64 -3.28986852673953 1.23159723864568e-57 miRanda -0.425294496309206 1.33933040314735e-25 NA NA NA hsa-miR-96-5p GPLD1 3.24596558166606 1.92296159041707e-98 -3.28986852673953 1.23159723864568e-57 MirTarget -0.496318446735872 4.2191524059444e-32 NA NA NA hsa-miR-200b-3p GPM6A 2.11744072703209 1.66710572104191e-43 -3.10286839785086 3.20941823581068e-24 TargetScan -0.371794675320626 2.05632837550936e-08 NA NA NA hsa-miR-200c-3p GPM6A 2.07038651806183 6.84613386286599e-51 -3.10286839785086 3.20941823581068e-24 miRNATAP -0.518383498002174 8.62940485369508e-13 NA NA NA hsa-miR-429 GPM6A 2.84108892259147 3.88520896426515e-64 -3.10286839785086 3.20941823581068e-24 PITA;miRanda;miRNATAP -0.425339528129547 4.9170477622306e-13 NA NA NA hsa-miR-96-5p GPM6A 3.24596558166606 1.92296159041707e-98 -3.10286839785086 3.20941823581068e-24 TargetScan;miRNATAP -0.556962406469686 5.65894339294641e-20 NA NA NA hsa-miR-141-3p GPM6B 2.99777540204168 1.26370498493024e-78 -2.23343254430802 1.51570824751064e-39 TargetScan;miRNATAP -0.245390711182634 7.50327373802732e-13 NA NA NA hsa-miR-200a-3p GPM6B 2.55218480823434 2.96135446816238e-51 -2.23343254430802 1.51570824751064e-39 miRNATAP -0.211572578694185 3.41175166606786e-10 NA NA NA hsa-miR-375 GPM6B 2.09893673049766 1.68351780396203e-16 -2.23343254430802 1.51570824751064e-39 miRanda -0.270095516956685 6.9963402906846e-33 NA NA NA hsa-miR-96-5p GPM6B 3.24596558166606 1.92296159041707e-98 -2.23343254430802 1.51570824751064e-39 TargetScan -0.390801367438579 1.43140309367827e-30 NA NA NA hsa-miR-141-3p GPR12 2.99777540204168 1.26370498493024e-78 -3.79560506584807 2.0728894670608e-29 TargetScan -0.451302857669628 1.89197608475184e-11 NA NA NA hsa-miR-200b-3p GPR12 2.11744072703209 1.66710572104191e-43 -3.79560506584807 2.0728894670608e-29 mirMAP -0.211209868194258 0.00439373819949444 NA NA NA hsa-miR-200c-3p GPR12 2.07038651806183 6.84613386286599e-51 -3.79560506584807 2.0728894670608e-29 mirMAP -0.356607875159398 1.14452341863566e-05 NA NA NA hsa-miR-429 GPR12 2.84108892259147 3.88520896426515e-64 -3.79560506584807 2.0728894670608e-29 mirMAP -0.318296274350737 1.37414862425482e-06 NA NA NA hsa-miR-200b-3p GPR146 2.11744072703209 1.66710572104191e-43 -2.68788146464682 1.82253967407916e-104 TargetScan -0.366631077549983 1.54794588342979e-37 NA NA NA hsa-miR-200c-3p GPR146 2.07038651806183 6.84613386286599e-51 -2.68788146464682 1.82253967407916e-104 miRNATAP -0.489498767203954 2.80922447941582e-57 NA NA NA hsa-miR-375 GPR146 2.09893673049766 1.68351780396203e-16 -2.68788146464682 1.82253967407916e-104 miRanda -0.126629253584628 6.15205091660366e-12 NA NA NA hsa-miR-429 GPR146 2.84108892259147 3.88520896426515e-64 -2.68788146464682 1.82253967407916e-104 miRanda;miRNATAP -0.379986362420708 8.80654135333999e-52 NA NA NA hsa-miR-141-3p GPR174 2.99777540204168 1.26370498493024e-78 -0.507026158628465 0.0307281737271767 TargetScan -0.184639515850209 5.01653974605598e-05 NA NA NA hsa-miR-200b-3p GPR180 2.11744072703209 1.66710572104191e-43 -0.419688671710059 4.52786653827531e-06 MirTarget -0.101528818679626 1.63749131202508e-07 NA NA NA hsa-miR-182-5p GPR183 2.36408084103818 2.60011457600281e-72 -0.316476299708043 0.0307569220776907 MirTarget -0.238057513957576 5.3322128585686e-12 NA NA NA hsa-miR-429 GPR183 2.84108892259147 3.88520896426515e-64 -0.316476299708043 0.0307569220776907 miRanda -0.109542392595817 7.65741020165016e-05 NA NA NA hsa-miR-139-5p GPR19 -3.25846663863766 2.62018989415003e-112 1.71094333238564 4.0167339998331e-24 miRanda -0.430719607329374 3.06287799426206e-36 NA NA NA hsa-miR-10b-5p GPR3 -2.10996264627796 7.36811595736367e-72 -0.0444372781274963 0.754491330038784 miRNATAP -0.219554236947126 4.96197237207719e-09 NA NA NA hsa-miR-182-5p GPR3 2.36408084103818 2.60011457600281e-72 -0.0444372781274963 0.754491330038784 mirMAP -0.123661896267508 0.000250636328636415 NA NA NA hsa-miR-335-5p GPR37L1 -2.61355235628987 2.6462884165886e-51 1.46615414504304 2.1291675147799e-11 miRNAWalker2_validate -0.154366429607771 0.000173259945531479 NA NA NA hsa-miR-429 GPR85 2.84108892259147 3.88520896426515e-64 -0.0559924434328337 0.600131255567534 miRanda -0.125566972107639 3.55571168036868e-10 NA NA NA hsa-miR-96-5p GPR85 3.24596558166606 1.92296159041707e-98 -0.0559924434328337 0.600131255567534 TargetScan -0.101850255438099 1.22548544719233e-06 NA NA NA hsa-miR-429 GPRASP1 2.84108892259147 3.88520896426515e-64 -2.35194041542028 1.15324764937426e-72 miRanda -0.370722705834482 9.94847996242408e-48 NA NA NA hsa-miR-182-5p GPRASP2 2.36408084103818 2.60011457600281e-72 -1.46110022232681 1.06931349502168e-53 miRNATAP -0.205351671087226 3.99936935384493e-18 NA NA NA hsa-miR-200b-3p GPRASP2 2.11744072703209 1.66710572104191e-43 -1.46110022232681 1.06931349502168e-53 MirTarget -0.18143118279187 7.24824069559743e-18 NA NA NA hsa-miR-200c-3p GPRASP2 2.07038651806183 6.84613386286599e-51 -1.46110022232681 1.06931349502168e-53 MirTarget -0.215737410728882 8.99657119648442e-21 NA NA NA hsa-miR-21-3p GPRASP2 2.17476065946878 5.15299442583591e-75 -1.46110022232681 1.06931349502168e-53 MirTarget -0.353332328012339 1.68248148790462e-44 NA NA NA hsa-miR-429 GPRASP2 2.84108892259147 3.88520896426515e-64 -1.46110022232681 1.06931349502168e-53 MirTarget;PITA;miRanda;miRNATAP -0.205490514457264 1.62689104512084e-28 NA NA NA hsa-miR-96-5p GPRASP2 3.24596558166606 1.92296159041707e-98 -1.46110022232681 1.06931349502168e-53 TargetScan;miRNATAP -0.213378218240284 3.24638003140917e-28 NA NA NA hsa-miR-141-3p GPRC5B 2.99777540204168 1.26370498493024e-78 -1.63910234589149 6.33269142418421e-39 mirMAP -0.227001607818957 1.38743014053449e-19 NA NA NA hsa-miR-200a-3p GPRC5B 2.55218480823434 2.96135446816238e-51 -1.63910234589149 6.33269142418421e-39 mirMAP -0.186081846741303 6.00471584593723e-14 NA NA NA hsa-miR-96-5p GPRC5B 3.24596558166606 1.92296159041707e-98 -1.63910234589149 6.33269142418421e-39 TargetScan -0.267748727056842 3.27220671455969e-26 NA NA NA hsa-miR-182-5p GPRIN2 2.36408084103818 2.60011457600281e-72 -1.2123336131336 7.16020898632495e-05 mirMAP -0.241972841275212 0.000914424438849525 NA NA NA hsa-miR-429 GPRIN3 2.84108892259147 3.88520896426515e-64 -0.139100050877869 0.387088328356132 miRanda -0.11063180028911 0.000272825305083837 NA NA NA hsa-miR-139-5p GPSM2 -3.25846663863766 2.62018989415003e-112 1.08446601620516 8.63793167808241e-24 miRanda -0.253617312997749 1.07258444609641e-30 NA NA NA hsa-miR-375 GRAMD1B 2.09893673049766 1.68351780396203e-16 -0.188151997374813 0.241605807391635 miRanda -0.126959955721634 1.49789234449411e-09 NA NA NA hsa-miR-96-5p GRAMD2 3.24596558166606 1.92296159041707e-98 -1.11418873381788 5.87176875973796e-06 TargetScan -0.205250281020152 2.54216272439305e-05 NA NA NA hsa-miR-21-5p GRAMD3 2.32007501846389 3.08394781855554e-137 -1.31668353228658 1.2478558736513e-38 MirTarget -0.191692703974092 5.42500183145492e-09 NA NA NA hsa-miR-141-3p GRAP2 2.99777540204168 1.26370498493024e-78 -0.397653992932544 0.0139807990551696 mirMAP -0.138508348654333 1.0102557093128e-05 NA NA NA hsa-miR-200a-3p GRAP2 2.55218480823434 2.96135446816238e-51 -0.397653992932544 0.0139807990551696 mirMAP -0.122937913930831 6.60870979530783e-05 NA NA NA hsa-miR-335-5p GRB7 -2.61355235628987 2.6462884165886e-51 1.50452648892084 2.61938409482722e-15 miRNAWalker2_validate -0.244948380452012 5.61762460802659e-12 NA NA NA hsa-miR-139-5p GREM1 -3.25846663863766 2.62018989415003e-112 0.931037098913743 4.48110163194541e-06 miRanda -0.232142309930125 2.63788130403564e-08 NA NA NA hsa-miR-183-5p GREM2 2.95681814393872 1.09965777344285e-92 -2.65211306689938 8.60704393228989e-30 miRNATAP -0.531477078253098 8.09048930137978e-27 NA NA NA hsa-miR-200b-3p GREM2 2.11744072703209 1.66710572104191e-43 -2.65211306689938 8.60704393228989e-30 TargetScan -0.455558823157359 1.52824133267104e-19 NA NA NA hsa-miR-375 GREM2 2.09893673049766 1.68351780396203e-16 -2.65211306689938 8.60704393228989e-30 miRanda;miRNATAP -0.149955937442218 2.54774633920013e-06 NA NA NA hsa-miR-429 GREM2 2.84108892259147 3.88520896426515e-64 -2.65211306689938 8.60704393228989e-30 miRNATAP -0.459544051707697 8.08519021270459e-25 NA NA NA hsa-miR-486-5p GRHL2 -3.87258704301474 1.22658629378451e-80 1.69249317105664 8.71708493554679e-30 MirTarget;PITA;miRanda;miRNATAP -0.270746603148569 5.01266361691959e-33 NA NA NA hsa-miR-511-5p GRHL2 -2.27545475897362 3.84085514050558e-36 1.69249317105664 8.71708493554679e-30 MirTarget -0.22964173054073 1.11408532641453e-16 NA NA NA hsa-miR-139-5p GRHL3 -3.25846663863766 2.62018989415003e-112 1.33243979571423 4.21489473570884e-09 miRanda -0.337529841301574 3.9687526195493e-13 NA NA NA hsa-miR-335-5p GRHL3 -2.61355235628987 2.6462884165886e-51 1.33243979571423 4.21489473570884e-09 miRNAWalker2_validate -0.235269990389991 2.55449719797268e-08 NA NA NA hsa-miR-96-5p GRIA1 3.24596558166606 1.92296159041707e-98 -3.82085820737327 7.29172111955098e-30 TargetScan -0.547628853307288 7.3715145659943e-16 NA NA NA hsa-miR-182-5p GRIA3 2.36408084103818 2.60011457600281e-72 -1.91377886156884 1.73562896253174e-17 miRNATAP -0.438318202941229 3.56778149611627e-16 NA NA NA hsa-miR-429 GRIA3 2.84108892259147 3.88520896426515e-64 -1.91377886156884 1.73562896253174e-17 miRanda -0.323602153418572 4.32549638287799e-14 NA NA NA hsa-miR-375 GRIA4 2.09893673049766 1.68351780396203e-16 -4.77196655087619 1.17769710567523e-48 miRanda -0.136966555233605 0.00269322084357658 NA NA NA hsa-miR-429 GRIA4 2.84108892259147 3.88520896426515e-64 -4.77196655087619 1.17769710567523e-48 miRanda -0.588100944502306 4.67154593378708e-20 NA NA NA hsa-miR-182-5p GRID1 2.36408084103818 2.60011457600281e-72 -1.26594797560263 4.62889296276057e-22 miRNATAP -0.311464391933211 1.93800031524508e-23 NA NA NA hsa-miR-429 GRID1 2.84108892259147 3.88520896426515e-64 -1.26594797560263 4.62889296276057e-22 miRNATAP -0.304244820837617 1.26719739227824e-35 NA NA NA hsa-miR-96-5p GRID1 3.24596558166606 1.92296159041707e-98 -1.26594797560263 4.62889296276057e-22 TargetScan;miRNATAP -0.324073359444686 3.61230192954218e-37 NA NA NA hsa-miR-21-5p GRIK3 2.32007501846389 3.08394781855554e-137 -0.89773844432763 0.00308658934970686 mirMAP -0.304631120717111 0.00129446770257955 NA NA NA hsa-miR-145-5p GRIK4 -2.62703571936687 7.64402900188551e-88 0.897296904823413 0.000510899507719862 MirTarget -0.243102366046916 5.09967263486442e-05 NA NA NA hsa-miR-429 GRIK5 2.84108892259147 3.88520896426515e-64 -1.21589501653952 5.48677800575739e-11 miRNATAP -0.157028408054703 9.27846046810005e-06 NA NA NA hsa-miR-335-5p GRIN1 -2.61355235628987 2.6462884165886e-51 0.816238120637237 0.00018247309853884 mirMAP -0.120216864037747 0.00310374497053473 NA NA NA hsa-miR-182-5p GRIN2A 2.36408084103818 2.60011457600281e-72 -1.82536115377551 6.42782297852272e-17 mirMAP -0.39854406378696 2.55857710432754e-14 NA NA NA hsa-miR-200b-3p GRIN2A 2.11744072703209 1.66710572104191e-43 -1.82536115377551 6.42782297852272e-17 TargetScan -0.266628421722217 1.32487494509074e-08 NA NA NA hsa-miR-335-5p GRIN2D -2.61355235628987 2.6462884165886e-51 1.7632089441916 8.98508719475004e-30 miRNAWalker2_validate -0.223194643368654 4.24025692917319e-14 NA NA NA hsa-miR-182-5p GRIN3A 2.36408084103818 2.60011457600281e-72 -0.624865745424297 1.84453735336025e-10 mirMAP -0.154390131326512 3.84874122317688e-11 NA NA NA hsa-miR-10b-5p GRINA -2.10996264627796 7.36811595736367e-72 0.696899496502476 2.27933922628917e-17 miRNAWalker2_validate -0.138690255954778 3.62583484101091e-10 NA NA NA hsa-miR-139-5p GRIP1 -3.25846663863766 2.62018989415003e-112 0.491348773314706 0.0019100345461611 miRanda -0.154216645850696 2.10148113176807e-06 NA NA NA hsa-miR-486-5p GRIP1 -3.87258704301474 1.22658629378451e-80 0.491348773314706 0.0019100345461611 miRanda -0.16961710503501 1.01455489090683e-12 NA NA NA hsa-miR-200b-3p GRK5 2.11744072703209 1.66710572104191e-43 -1.21175050643001 7.9828104448934e-42 TargetScan -0.199693982300283 7.93076453613617e-25 NA NA NA hsa-miR-101-3p GSK3B -0.126035286271986 0.145997832808138 0.16507499183074 0.0104993269942212 miRNATAP -0.1804025732635 1.07790099640944e-12 NA NA NA hsa-miR-181a-5p GSK3B 0.635863607630183 6.72486918157744e-11 0.16507499183074 0.0104993269942212 mirMAP -0.116539047078398 1.93667948800215e-07 NA NA NA hsa-miR-26a-5p GSK3B -0.481180084102235 1.82368246174758e-10 0.16507499183074 0.0104993269942212 miRNAWalker2_validate;miRNATAP -0.275908606747704 3.58443650423207e-22 NA NA NA hsa-miR-29a-3p GSK3B -0.699539666833076 1.13935003139957e-13 0.16507499183074 0.0104993269942212 miRNATAP -0.20395154397803 2.73691130456682e-19 NA NA NA hsa-miR-29c-3p GSK3B -0.0652732378039769 0.563774115756922 0.16507499183074 0.0104993269942212 miRNATAP -0.148921210430456 1.24088422020447e-14 NA NA NA hsa-miR-320a GSK3B -0.287921276129346 0.00141693637596294 0.16507499183074 0.0104993269942212 miRanda;mirMAP -0.129942826481556 1.0429094971177e-07 NA NA NA hsa-miR-340-5p GSK3B 1.0857159627596 4.94471062546756e-24 0.16507499183074 0.0104993269942212 mirMAP -0.119708017508741 1.77864671732598e-09 NA NA NA hsa-miR-374a-5p GSK3B -0.239709888246804 0.00309819667153627 0.16507499183074 0.0104993269942212 mirMAP -0.161835653986741 2.7137832607523e-09 NA NA NA hsa-miR-542-3p GSK3B 0.568822103820889 8.5699075257651e-07 0.16507499183074 0.0104993269942212 miRanda -0.110477181605807 5.02640445089489e-09 NA NA NA hsa-miR-141-3p GSN 2.99777540204168 1.26370498493024e-78 -2.23393150379953 1.72954577951929e-91 MirTarget -0.429152218739585 1.26954723595622e-88 NA NA NA hsa-miR-200a-3p GSN 2.55218480823434 2.96135446816238e-51 -2.23393150379953 1.72954577951929e-91 MirTarget -0.311256977660154 3.70009189291315e-44 NA NA NA hsa-miR-429 GSN 2.84108892259147 3.88520896426515e-64 -2.23393150379953 1.72954577951929e-91 miRanda -0.325595839117764 1.91505728889962e-49 NA NA NA hsa-miR-429 GSPT2 2.84108892259147 3.88520896426515e-64 -1.50381425088804 4.75597519472232e-26 miRanda -0.21602901169174 3.22975926261646e-15 NA NA NA hsa-miR-486-5p GSTO2 -3.87258704301474 1.22658629378451e-80 0.664569312870734 9.83723699214313e-05 miRanda -0.125554226407699 1.24828490251009e-06 NA NA NA hsa-miR-21-5p GTF2A1 2.32007501846389 3.08394781855554e-137 -0.707406837538239 1.08698731198543e-05 miRNAWalker2_validate -0.283152764965146 1.49524978983624e-08 NA NA NA hsa-miR-96-5p GTF2A1 3.24596558166606 1.92296159041707e-98 -0.707406837538239 1.08698731198543e-05 miRNAWalker2_validate -0.108259644911326 0.000693230142674877 NA NA NA hsa-miR-139-5p GTF2E1 -3.25846663863766 2.62018989415003e-112 0.406768730575471 1.18510093091108e-11 miRanda -0.105390911138712 6.97684464227459e-18 NA NA NA hsa-miR-21-5p GTF2I 2.32007501846389 3.08394781855554e-137 -0.266944615119853 0.0105248510010252 miRNAWalker2_validate -0.220348671606198 7.42280681170713e-12 NA NA NA hsa-miR-139-5p GTSE1 -3.25846663863766 2.62018989415003e-112 3.15237963595094 3.60980225897754e-81 miRanda -0.592741491633758 3.08579032878793e-65 NA NA NA hsa-miR-429 GUCY1A2 2.84108892259147 3.88520896426515e-64 -0.571433910932659 0.00168533419240491 MirTarget;miRNATAP -0.264924342431622 6.64971809058354e-15 NA NA NA hsa-miR-200b-3p GUCY1A3 2.11744072703209 1.66710572104191e-43 -1.26223066041775 1.17870821628152e-20 TargetScan -0.200877890949908 5.08189961103363e-12 NA NA NA hsa-miR-429 GUCY1A3 2.84108892259147 3.88520896426515e-64 -1.26223066041775 1.17870821628152e-20 miRNATAP -0.201266208378786 7.56343484212906e-15 NA NA NA hsa-miR-429 GUCY1B3 2.84108892259147 3.88520896426515e-64 -0.361185978057375 0.000114687553173302 miRanda -0.130694972143373 9.17206738851888e-14 NA NA NA hsa-miR-452-5p GUF1 -2.48486455572568 1.24430987974325e-33 0.122874608754051 0.0822435353681716 MirTarget -0.102538809335099 1.38180797462674e-20 NA NA NA hsa-miR-429 GULP1 2.84108892259147 3.88520896426515e-64 -1.94467535837848 1.33674495102449e-37 miRanda -0.333941665260397 1.36657577327322e-30 NA NA NA hsa-miR-21-5p GXYLT1 2.32007501846389 3.08394781855554e-137 -0.134616854128901 0.0356750701920917 mirMAP -0.1211365090473 8.8863049905298e-10 NA NA NA hsa-miR-182-5p GXYLT2 2.36408084103818 2.60011457600281e-72 -0.0463175603061918 0.788135628617274 MirTarget -0.163761802266649 6.33074600818132e-05 NA NA NA hsa-miR-196a-5p GYG2 2.33423717464504 3.646557504928e-18 -3.51302071594925 7.99133789913513e-74 miRNATAP -0.109475252227361 3.37823141153986e-05 NA NA NA hsa-miR-145-5p H2AFX -2.62703571936687 7.64402900188551e-88 1.9343631800414 6.58083947273181e-65 MirTarget;miRNATAP -0.385763991872566 5.21940074199578e-46 NA NA NA hsa-miR-486-5p H2AFZ -3.87258704301474 1.22658629378451e-80 1.39581285741761 7.29068140302154e-61 miRanda -0.123939849858126 7.9965142001582e-20 NA NA NA hsa-miR-141-5p H6PD 2.38411349683216 4.56310582620282e-58 -0.858645530203666 1.48469482405532e-35 mirMAP -0.168203540303789 1.99084984435227e-29 NA NA NA hsa-miR-96-5p H6PD 3.24596558166606 1.92296159041707e-98 -0.858645530203666 1.48469482405532e-35 TargetScan -0.184981745139805 1.14251260174018e-42 NA NA NA hsa-miR-429 HABP4 2.84108892259147 3.88520896426515e-64 -1.03836143553671 3.85374267042339e-35 miRNATAP -0.176977608746107 2.88505293986634e-28 NA NA NA hsa-miR-429 HAND2 2.84108892259147 3.88520896426515e-64 -1.39591113709582 8.13949878118042e-19 miRanda;miRNATAP -0.277239815228794 1.45002698710164e-20 NA NA NA hsa-miR-335-5p HAPLN1 -2.61355235628987 2.6462884165886e-51 3.73782139105968 1.07086262943358e-32 miRNAWalker2_validate -0.566471556499473 1.20090309797612e-21 NA NA NA hsa-miR-337-3p HAPLN1 -2.14274617598363 2.70942896809734e-43 3.73782139105968 1.07086262943358e-32 MirTarget;mirMAP -0.365783004190424 7.30083257660284e-08 NA NA NA hsa-miR-141-3p HAS2 2.99777540204168 1.26370498493024e-78 -0.73254277727189 5.09218971882186e-05 MirTarget -0.39679145747752 1.7600904425533e-31 NA NA NA hsa-miR-200a-3p HAS2 2.55218480823434 2.96135446816238e-51 -0.73254277727189 5.09218971882186e-05 MirTarget -0.353512405426644 6.84947603905191e-26 NA NA NA hsa-miR-200b-3p HAS2 2.11744072703209 1.66710572104191e-43 -0.73254277727189 5.09218971882186e-05 TargetScan -0.381713491509829 2.09029477468797e-24 NA NA NA hsa-miR-375 HAS2 2.09893673049766 1.68351780396203e-16 -0.73254277727189 5.09218971882186e-05 miRNATAP -0.229653671475269 7.23479140388919e-23 NA NA NA hsa-miR-429 HAS2 2.84108892259147 3.88520896426515e-64 -0.73254277727189 5.09218971882186e-05 miRanda;miRNATAP -0.287942341073617 1.40635569972833e-17 NA NA NA hsa-miR-96-5p HAS2 3.24596558166606 1.92296159041707e-98 -0.73254277727189 5.09218971882186e-05 TargetScan -0.331878657853853 2.79099386558272e-21 NA NA NA hsa-miR-375 HAS3 2.09893673049766 1.68351780396203e-16 -3.33737363445779 1.70838289491702e-69 miRanda -0.185665653321465 5.77587244310212e-12 NA NA NA hsa-miR-139-5p HAUS8 -3.25846663863766 2.62018989415003e-112 0.835488190452808 3.28468232717201e-24 miRanda -0.177794276291977 7.56659698374825e-26 NA NA NA hsa-miR-182-5p HBEGF 2.36408084103818 2.60011457600281e-72 -1.07492699127294 1.02818888149412e-20 MirTarget;miRNATAP -0.288103259478583 4.49643855423297e-26 NA NA NA hsa-miR-183-5p HBEGF 2.95681814393872 1.09965777344285e-92 -1.07492699127294 1.02818888149412e-20 miRNATAP -0.257403944678662 1.30507752394387e-26 NA NA NA hsa-miR-96-5p HBEGF 3.24596558166606 1.92296159041707e-98 -1.07492699127294 1.02818888149412e-20 MirTarget;TargetScan;miRNATAP -0.242324835628154 8.52709044535985e-27 NA NA NA hsa-miR-21-5p HBP1 2.32007501846389 3.08394781855554e-137 -0.609633493054902 2.65121556393279e-29 miRNATAP -0.25898640261103 5.87675612636637e-57 26282675 MicroRNA 21 is a potential link between non alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1 p53 Srebp1c pathway; Further studies revealed that Hbp1 was a novel target of microRNA-21 and a transcriptional activator of p53 liver cancer hsa-miR-200a-5p HCFC2 2.58844508672328 1.79650654234569e-56 -0.803119337578588 3.92380604887554e-30 MirTarget;miRNATAP -0.106316601431691 3.70796412699017e-14 NA NA NA hsa-miR-200b-3p HCFC2 2.11744072703209 1.66710572104191e-43 -0.803119337578588 3.92380604887554e-30 TargetScan -0.147663931194614 1.23166442175703e-22 NA NA NA hsa-miR-200c-3p HCFC2 2.07038651806183 6.84613386286599e-51 -0.803119337578588 3.92380604887554e-30 miRNATAP -0.163766538126611 5.10038680592063e-23 NA NA NA hsa-miR-429 HCFC2 2.84108892259147 3.88520896426515e-64 -0.803119337578588 3.92380604887554e-30 MirTarget;miRanda;miRNATAP -0.144158099754118 4.953694819061e-27 NA NA NA hsa-miR-378a-5p HDAC11 -2.43173551693523 1.44932837789175e-68 1.02944284112973 1.51693657172479e-18 mirMAP -0.363205198806869 1.27755363736039e-45 NA NA NA hsa-miR-141-3p HDAC4 2.99777540204168 1.26370498493024e-78 -0.934609358419622 1.12652265115551e-31 TargetScan;miRNATAP -0.160502237044914 1.21270290273257e-24 NA NA NA hsa-miR-141-5p HDAC4 2.38411349683216 4.56310582620282e-58 -0.934609358419622 1.12652265115551e-31 miRNATAP -0.161704064802871 1.48474455817816e-20 NA NA NA hsa-miR-200a-3p HDAC4 2.55218480823434 2.96135446816238e-51 -0.934609358419622 1.12652265115551e-31 miRNATAP -0.111591573155961 8.74946122048941e-13 21837748 Furthermore our results suggested that the histone deacetylase 4 HDAC4 inhibited the expression of miR-200a and its promoter activity and reduced the histone H3 acetylation level at the mir-200a promoter through a Sp1-dependent pathway; Interestingly we observed that the miR-200a directly targeted the 3'-untranslated region of the HDAC4 messenger RNA and repressed expression of HDAC4; Through targeting HDAC4 miR-200a also induced the up-regulation of total acetyl-histone H3 levels and increased the histone H3 acetylation level at the p21WAF/Cip1 promoter; Our findings suggest that the HDAC4/Sp1/miR-200a regulatory network induces the down-regulation of miR-200a and the up-regulation of HDAC4 in HCC liver cancer hsa-miR-200b-3p HDAC4 2.11744072703209 1.66710572104191e-43 -0.934609358419622 1.12652265115551e-31 TargetScan -0.107002513608626 8.30409107669982e-10 NA NA NA hsa-miR-200c-3p HDAC4 2.07038651806183 6.84613386286599e-51 -0.934609358419622 1.12652265115551e-31 miRNATAP -0.172004226515195 9.63413369129246e-20 NA NA NA hsa-miR-429 HDAC4 2.84108892259147 3.88520896426515e-64 -0.934609358419622 1.12652265115551e-31 PITA;miRNATAP -0.119431591436962 1.13697817461966e-14 NA NA NA hsa-miR-139-5p HDAC8 -3.25846663863766 2.62018989415003e-112 0.436441527751981 2.4405201975734e-17 miRanda -0.102613546135681 1.66657298128354e-22 NA NA NA hsa-miR-182-5p HDAC9 2.36408084103818 2.60011457600281e-72 -0.807801293186906 8.19301024784526e-07 miRNATAP -0.282973377603055 2.88113304746138e-13 26858310 HDAC Inhibition Induces MicroRNA 182 which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia; HR reporter assays apoptotic assays and colony-forming assays established that the miR-182 as well as the HDAC inhibition-mediated decreases in RAD51 inhibited HR repair and sensitized cells to sapacitabine; HDAC inhibition induced miR-182 in AML cell lines and primary AML blasts; Overexpression of miR-182 as well as HDAC inhibition-mediated induction of miR-182 were linked to time- and dose-dependent decreases in the levels of RAD51 an inhibition of HR increased levels of residual damage and decreased survival after exposure to double-strand damage-inducing agents; Our findings define the mechanism by which HDAC inhibition induces miR-182 to target RAD51 and highlights a novel pharmacologic strategy that compromises the ability of AML cells to conduct HR thereby sensitizing AML cells to DNA-damaging agents that activate HR as a repair and potential resistance mechanism poor survival;drug resistance acute myeloid leukemia hsa-miR-96-5p HDAC9 3.24596558166606 1.92296159041707e-98 -0.807801293186906 8.19301024784526e-07 TargetScan;miRNATAP -0.197517739465025 9.82054034414196e-10 NA NA NA hsa-miR-429 HDC 2.84108892259147 3.88520896426515e-64 -0.965729427865039 0.00010852058933711 miRanda -0.307957974481158 5.40232873319689e-11 NA NA NA hsa-miR-139-5p HDGF -3.25846663863766 2.62018989415003e-112 1.21794900739012 9.28750585640558e-62 PITA;miRanda;miRNATAP -0.24317087141288 1.33353934624917e-57 NA NA NA hsa-miR-21-5p HECTD1 2.32007501846389 3.08394781855554e-137 -0.516001737313778 3.7252295789372e-12 miRNAWalker2_validate -0.224768458276273 6.98871042038719e-23 NA NA NA hsa-miR-141-3p HECW1 2.99777540204168 1.26370498493024e-78 -0.981727234424162 1.87120447192368e-07 TargetScan -0.186794162262921 3.55223020531038e-07 NA NA NA hsa-miR-200b-3p HECW2 2.11744072703209 1.66710572104191e-43 -0.358493289445225 0.00117705895738507 TargetScan -0.18386213114201 1.73022555715788e-15 NA NA NA hsa-miR-429 HECW2 2.84108892259147 3.88520896426515e-64 -0.358493289445225 0.00117705895738507 miRNATAP -0.148234859860434 8.02216360613556e-13 NA NA NA hsa-miR-200b-3p HEG1 2.11744072703209 1.66710572104191e-43 -0.959876443317947 5.58216106035e-19 TargetScan -0.287685439750528 5.65747549286244e-38 NA NA NA hsa-miR-429 HEG1 2.84108892259147 3.88520896426515e-64 -0.959876443317947 5.58216106035e-19 miRanda;miRNATAP -0.257784344694438 2.98242603059584e-38 NA NA NA hsa-miR-139-5p HEPHL1 -3.25846663863766 2.62018989415003e-112 0.427056952464092 0.0640835028318306 miRanda -0.169190491096308 0.000360804453610906 NA NA NA hsa-miR-429 HERC2P2 2.84108892259147 3.88520896426515e-64 -1.16346700044327 1.40952440640101e-29 miRanda -0.117099039346713 5.38523320653608e-09 NA NA NA hsa-miR-21-3p HERC3 2.17476065946878 5.15299442583591e-75 -0.775171285293458 4.10088276080873e-14 MirTarget -0.131905560204501 1.34514519732251e-06 NA NA NA hsa-miR-429 HERC3 2.84108892259147 3.88520896426515e-64 -0.775171285293458 4.10088276080873e-14 miRanda -0.121523900685341 5.09586737874056e-10 NA NA NA hsa-miR-21-5p HERPUD2 2.32007501846389 3.08394781855554e-137 -0.271384148901615 7.7392011904778e-14 miRNAWalker2_validate -0.105623791757372 2.47150913726809e-21 NA NA NA hsa-miR-335-5p HES2 -2.61355235628987 2.6462884165886e-51 1.59084379597528 5.48063715059659e-11 miRNAWalker2_validate -0.259615854923977 9.83443039012541e-09 NA NA NA hsa-miR-139-5p HES4 -3.25846663863766 2.62018989415003e-112 1.64843442946424 5.81790253016274e-20 miRanda -0.240267957251404 1.6972831380758e-10 NA NA NA hsa-miR-429 HEY1 2.84108892259147 3.88520896426515e-64 -0.678863507106594 5.79332142625051e-10 miRanda -0.146240842450656 1.62317306036692e-12 NA NA NA hsa-miR-429 HFE 2.84108892259147 3.88520896426515e-64 -0.686423152605472 1.26667860368595e-08 miRanda;miRNATAP -0.122520655834557 8.77789857912046e-08 NA NA NA hsa-miR-141-3p HGF 2.99777540204168 1.26370498493024e-78 -1.50227719275535 2.60659514703213e-20 MirTarget;TargetScan -0.460530345225581 6.82815824837891e-52 NA NA NA hsa-miR-200a-3p HGF 2.55218480823434 2.96135446816238e-51 -1.50227719275535 2.60659514703213e-20 MirTarget -0.395550183948552 6.66851532585504e-39 NA NA NA hsa-miR-429 HGF 2.84108892259147 3.88520896426515e-64 -1.50227719275535 2.60659514703213e-20 miRanda -0.390119016718709 2.48108439155069e-38 NA NA NA hsa-miR-486-5p HHAT -3.87258704301474 1.22658629378451e-80 0.644196417869949 1.52387006114795e-08 MirTarget;miRanda -0.106597858752885 6.91074771376564e-10 NA NA NA hsa-miR-335-5p HHIPL1 -2.61355235628987 2.6462884165886e-51 0.452556457672158 0.000519106325271349 mirMAP -0.174222526081631 3.59587684888314e-13 NA NA NA hsa-miR-182-5p HIF3A 2.36408084103818 2.60011457600281e-72 -5.27831973350434 1.81481983399704e-88 mirMAP -0.934754643389345 1.83799654132809e-44 NA NA NA hsa-miR-429 HIF3A 2.84108892259147 3.88520896426515e-64 -5.27831973350434 1.81481983399704e-88 miRNATAP -0.638547876065293 2.6986361400363e-32 NA NA NA hsa-miR-21-5p HIPK1 2.32007501846389 3.08394781855554e-137 -0.476594328469731 3.92964362646836e-10 mirMAP -0.204008795337524 3.83283414565148e-18 NA NA NA hsa-miR-21-3p HIPK2 2.17476065946878 5.15299442583591e-75 -0.953765945586234 3.35720241682395e-14 mirMAP -0.250258632794867 4.38865382640861e-14 NA NA NA hsa-miR-429 HIPK2 2.84108892259147 3.88520896426515e-64 -0.953765945586234 3.35720241682395e-14 miRNATAP -0.106917581749675 9.27629740074061e-06 NA NA NA hsa-miR-141-3p HIPK3 2.99777540204168 1.26370498493024e-78 -1.48141194897483 7.96609771227689e-17 MirTarget;TargetScan -0.249329270801133 7.77789779889137e-13 NA NA NA hsa-miR-200a-3p HIPK3 2.55218480823434 2.96135446816238e-51 -1.48141194897483 7.96609771227689e-17 MirTarget -0.241709563697712 1.47010706104349e-12 NA NA NA hsa-miR-200b-3p HIPK3 2.11744072703209 1.66710572104191e-43 -1.48141194897483 7.96609771227689e-17 MirTarget;TargetScan -0.254884315698111 2.08715524349576e-11 NA NA NA hsa-miR-200c-3p HIPK3 2.07038651806183 6.84613386286599e-51 -1.48141194897483 7.96609771227689e-17 MirTarget -0.251079858804093 2.15324394786841e-09 NA NA NA hsa-miR-21-5p HIPK3 2.32007501846389 3.08394781855554e-137 -1.48141194897483 7.96609771227689e-17 MirTarget -0.521097587045661 3.6320364906261e-21 NA NA NA hsa-miR-429 HIPK3 2.84108892259147 3.88520896426515e-64 -1.48141194897483 7.96609771227689e-17 MirTarget;miRanda -0.257880359928691 2.52930492569702e-14 NA NA NA hsa-miR-139-3p HIST2H2AA3 -3.44089023199323 1.67292890850702e-91 2.78794101272401 4.1861276928093e-57 miRNATAP -0.360971425656393 4.33549301745991e-28 NA NA NA hsa-miR-139-5p HIST2H4A -3.25846663863766 2.62018989415003e-112 1.8433805287041 1.96311258226856e-31 miRanda -0.347197035633268 3.58504714150993e-26 NA NA NA hsa-miR-429 HIVEP2 2.84108892259147 3.88520896426515e-64 -0.835685106687369 1.19413317704528e-17 miRanda;miRNATAP -0.169771301568547 3.66109340147882e-20 NA NA NA hsa-miR-21-5p HIVEP3 2.32007501846389 3.08394781855554e-137 -0.278619458806825 0.000589541736585678 mirMAP -0.129667316226954 2.58007847407097e-07 NA NA NA hsa-miR-10b-5p HK1 -2.10996264627796 7.36811595736367e-72 0.634255693487897 1.63152012299018e-29 miRNAWalker2_validate -0.108933904114256 1.08298046973335e-12 NA NA NA hsa-miR-182-5p HLA-DOA 2.36408084103818 2.60011457600281e-72 -0.0748945090661213 0.569677360581235 mirMAP -0.170859436068828 4.15560006854201e-08 NA NA NA hsa-miR-335-5p HLA-DRB5 -2.61355235628987 2.6462884165886e-51 0.640514531499534 0.000613851321491489 miRNAWalker2_validate -0.144051413004106 3.3683337076349e-05 NA NA NA hsa-miR-375 HLA-F 2.09893673049766 1.68351780396203e-16 0.498132115610089 0.00038064325918255 miRanda -0.127331355925977 3.6563550953033e-12 NA NA NA hsa-miR-141-3p HLF 2.99777540204168 1.26370498493024e-78 -3.73360626511854 1.05238992329545e-69 TargetScan -0.574632690101698 3.11279106663662e-41 NA NA NA hsa-miR-200b-3p HLF 2.11744072703209 1.66710572104191e-43 -3.73360626511854 1.05238992329545e-69 MirTarget;TargetScan -0.41260266276059 9.48573331809416e-18 NA NA NA hsa-miR-200c-3p HLF 2.07038651806183 6.84613386286599e-51 -3.73360626511854 1.05238992329545e-69 MirTarget;miRNATAP -0.548910593689306 9.52882721075114e-26 NA NA NA hsa-miR-429 HLF 2.84108892259147 3.88520896426515e-64 -3.73360626511854 1.05238992329545e-69 MirTarget;PITA;miRanda;miRNATAP -0.48361445321537 2.30975623056168e-30 NA NA NA hsa-miR-139-5p HM13 -3.25846663863766 2.62018989415003e-112 1.10262018434266 2.27759961288674e-58 miRanda -0.204624703894583 2.17167600587036e-46 NA NA NA hsa-miR-200b-3p HMBOX1 2.11744072703209 1.66710572104191e-43 -0.729256061931685 4.98979109584954e-11 MirTarget;TargetScan -0.124645179291517 1.39616853319627e-07 NA NA NA hsa-miR-200c-3p HMBOX1 2.07038651806183 6.84613386286599e-51 -0.729256061931685 4.98979109584954e-11 MirTarget;miRNATAP -0.126429591630189 1.22747960113523e-06 NA NA NA hsa-miR-429 HMBOX1 2.84108892259147 3.88520896426515e-64 -0.729256061931685 4.98979109584954e-11 MirTarget;PITA;miRanda;miRNATAP -0.128095625462679 1.22803395273628e-09 NA NA NA hsa-miR-182-5p HMCN1 2.36408084103818 2.60011457600281e-72 -1.14022904841935 4.93770191832628e-10 MirTarget -0.291296523964545 2.54259237520524e-11 NA NA NA hsa-miR-335-5p HMGA1 -2.61355235628987 2.6462884165886e-51 1.5358410799772 5.78250243633113e-40 miRNAWalker2_validate -0.235456832964684 8.12875633564572e-27 NA NA NA hsa-miR-486-5p HMGA2 -3.87258704301474 1.22658629378451e-80 1.34138826763155 5.71747379356545e-11 miRanda -0.191109273486735 9.13013333458832e-10 NA NA NA hsa-miR-139-5p HMGB2 -3.25846663863766 2.62018989415003e-112 0.873947554930812 3.90886189088511e-19 miRanda -0.185358884025299 3.06361977734638e-20 NA NA NA hsa-miR-335-5p HMGB3 -2.61355235628987 2.6462884165886e-51 2.1505918750238 7.04917288154587e-52 miRNAWalker2_validate -0.300408867113824 2.57621104076076e-28 NA NA NA hsa-miR-337-3p HMGB3 -2.14274617598363 2.70942896809734e-43 2.1505918750238 7.04917288154587e-52 mirMAP -0.302490343308821 1.14941116629133e-22 NA NA NA hsa-miR-182-5p HMGCLL1 2.36408084103818 2.60011457600281e-72 -2.25682333406814 2.05144675903622e-16 miRNATAP -0.200652994892331 0.0026178767727342 NA NA NA hsa-miR-429 HMGCLL1 2.84108892259147 3.88520896426515e-64 -2.25682333406814 2.05144675903622e-16 miRanda;miRNATAP -0.189781974964179 0.000337406453392045 NA NA NA hsa-miR-139-5p HMGN2 -3.25846663863766 2.62018989415003e-112 0.579965910126808 3.21118451759678e-21 miRanda -0.124408367530307 4.82562527066934e-23 NA NA NA hsa-miR-335-5p HMOX1 -2.61355235628987 2.6462884165886e-51 0.775897516414696 4.81266920645005e-11 miRNAWalker2_validate -0.111731677289133 4.06294294802859e-07 NA NA NA hsa-miR-145-5p HN1L -2.62703571936687 7.64402900188551e-88 1.25611820070996 3.45460270418527e-58 mirMAP -0.200621439222817 2.88770713629468e-26 NA NA NA hsa-miR-141-3p HNMT 2.99777540204168 1.26370498493024e-78 -1.00611960537761 3.59848728302546e-29 TargetScan -0.222415586621322 5.01074473971309e-38 NA NA NA hsa-miR-429 HNMT 2.84108892259147 3.88520896426515e-64 -1.00611960537761 3.59848728302546e-29 miRNATAP -0.200750638672675 2.05569345777714e-32 NA NA NA hsa-miR-139-5p HNRNPAB -3.25846663863766 2.62018989415003e-112 1.15396288484794 5.79863010355694e-65 miRanda -0.216884617402397 7.22244233427539e-53 NA NA NA hsa-miR-139-5p HNRNPC -3.25846663863766 2.62018989415003e-112 0.558042749433318 4.08822229193854e-45 miRanda -0.120199120497418 2.79276906345516e-50 NA NA NA hsa-miR-10b-5p HNRNPF -2.10996264627796 7.36811595736367e-72 0.712012225822365 1.81519034511839e-41 miRNAWalker2_validate -0.12960558061213 3.1772122398067e-19 NA NA NA hsa-miR-139-5p HNRNPF -3.25846663863766 2.62018989415003e-112 0.712012225822365 1.81519034511839e-41 miRanda;miRNATAP -0.137452840978346 2.53047343584602e-36 NA NA NA hsa-miR-139-5p HNRNPU -3.25846663863766 2.62018989415003e-112 0.523938609838741 9.11557621656105e-40 miRanda -0.12046929950755 5.20827615285156e-51 NA NA NA hsa-miR-224-5p HOOK1 -2.22249420723892 1.07787949391113e-18 1.26824245301338 3.73818356198544e-20 MirTarget -0.137636419787246 1.08896338643111e-13 NA NA NA hsa-miR-335-5p HOOK1 -2.61355235628987 2.6462884165886e-51 1.26824245301338 3.73818356198544e-20 miRNAWalker2_validate -0.116867901718103 7.82398535988538e-06 NA NA NA hsa-miR-96-5p HOOK3 3.24596558166606 1.92296159041707e-98 -0.646547577592791 3.05007761810557e-15 MirTarget;TargetScan -0.105427573603611 1.01027128587563e-10 NA NA NA hsa-miR-429 HOXA1 2.84108892259147 3.88520896426515e-64 -1.00999705828073 6.8814503372889e-17 miRanda -0.179803472751095 5.34301825303462e-15 NA NA NA hsa-miR-141-3p HOXA11 2.99777540204168 1.26370498493024e-78 0.610518541755563 0.00131770850668378 TargetScan;miRNATAP -0.152235638281847 3.75602155268976e-05 NA NA NA hsa-miR-200a-3p HOXA11 2.55218480823434 2.96135446816238e-51 0.610518541755563 0.00131770850668378 miRNATAP -0.186921017890231 2.29686019657857e-07 NA NA NA hsa-miR-335-5p HOXA11 -2.61355235628987 2.6462884165886e-51 0.610518541755563 0.00131770850668378 miRNAWalker2_validate -0.12998474082199 0.000234202763724109 NA NA NA hsa-miR-429 HOXA13 2.84108892259147 3.88520896426515e-64 -1.13949942125974 9.85116126729329e-07 miRanda -0.331208683910911 3.66643593130331e-14 NA NA NA hsa-miR-210-3p HOXA3 2.38367203491819 3.73261999106754e-22 -2.36187003963078 4.27498676842218e-42 miRNAWalker2_validate -0.256519725822155 1.35582857713404e-26 NA NA NA hsa-miR-375 HOXA3 2.09893673049766 1.68351780396203e-16 -2.36187003963078 4.27498676842218e-42 miRanda;miRNATAP -0.21571146713758 6.8368847728706e-20 NA NA NA hsa-miR-429 HOXA3 2.84108892259147 3.88520896426515e-64 -2.36187003963078 4.27498676842218e-42 miRanda;miRNATAP -0.36323970382377 3.09123415147521e-27 NA NA NA hsa-miR-183-5p HOXA5 2.95681814393872 1.09965777344285e-92 -3.01456089936248 1.31977175737153e-66 miRNAWalker2_validate -0.566522598945463 3.35681928943666e-51 NA NA NA hsa-miR-200b-3p HOXA5 2.11744072703209 1.66710572104191e-43 -3.01456089936248 1.31977175737153e-66 TargetScan -0.413077170984604 5.07618077905355e-26 NA NA NA hsa-miR-429 HOXA5 2.84108892259147 3.88520896426515e-64 -3.01456089936248 1.31977175737153e-66 PITA;miRanda;miRNATAP -0.451062661519865 2.22273881094804e-39 NA NA NA hsa-miR-96-5p HOXA5 3.24596558166606 1.92296159041707e-98 -3.01456089936248 1.31977175737153e-66 TargetScan;miRNATAP -0.510102179856525 8.81479602860689e-47 NA NA NA hsa-miR-375 HOXA7 2.09893673049766 1.68351780396203e-16 -2.66233366186079 6.15928913475097e-51 miRanda -0.17298698456486 2.21837226875451e-12 NA NA NA hsa-miR-429 HOXA7 2.84108892259147 3.88520896426515e-64 -2.66233366186079 6.15928913475097e-51 miRNATAP -0.430562462904846 3.74792063680265e-36 NA NA NA hsa-miR-182-5p HOXA9 2.36408084103818 2.60011457600281e-72 -2.51701243665575 2.02680334794481e-43 miRNATAP -0.411258256550462 4.56012912195035e-20 NA NA NA hsa-miR-21-5p HOXA9 2.32007501846389 3.08394781855554e-137 -2.51701243665575 2.02680334794481e-43 miRNAWalker2_validate -0.504338752822271 9.99706963548109e-18 NA NA NA hsa-miR-210-3p HOXA9 2.38367203491819 3.73261999106754e-22 -2.51701243665575 2.02680334794481e-43 miRNAWalker2_validate;miRTarBase -0.20856023851932 3.71161302588325e-16 NA NA NA hsa-miR-96-5p HOXA9 3.24596558166606 1.92296159041707e-98 -2.51701243665575 2.02680334794481e-43 miRNAWalker2_validate;miRNATAP -0.429107241922965 1.06740790073268e-31 NA NA NA hsa-miR-141-3p HOXB5 2.99777540204168 1.26370498493024e-78 0.302409356822888 0.214170316650101 miRNAWalker2_validate;TargetScan;miRNATAP -0.12785333431879 0.00689890084074076 NA NA NA hsa-miR-200b-3p HOXB5 2.11744072703209 1.66710572104191e-43 0.302409356822888 0.214170316650101 miRNAWalker2_validate -0.13052183114126 0.0115081039515208 NA NA NA hsa-miR-200c-3p HOXB5 2.07038651806183 6.84613386286599e-51 0.302409356822888 0.214170316650101 miRNAWalker2_validate -0.225962472200039 6.62396588937751e-05 NA NA NA hsa-miR-429 HOXB5 2.84108892259147 3.88520896426515e-64 0.302409356822888 0.214170316650101 miRNAWalker2_validate -0.10107599671433 0.028500970110114 NA NA NA hsa-miR-429 HOXB8 2.84108892259147 3.88520896426515e-64 -1.13598654792682 1.05902370008481e-08 miRNATAP -0.239389488384743 1.89654689160763e-10 NA NA NA hsa-miR-139-5p HOXB9 -3.25846663863766 2.62018989415003e-112 1.27668617908035 3.75202721156742e-12 miRanda -0.282918615936417 7.26823417597715e-14 NA NA NA hsa-miR-145-5p HOXC11 -2.62703571936687 7.64402900188551e-88 3.49353922396973 6.90770469505975e-25 miRNATAP -0.565054105800959 1.87369555690036e-12 NA NA NA hsa-miR-429 HOXC8 2.84108892259147 3.88520896426515e-64 -0.477352888619082 8.5883603944161e-06 miRNATAP -0.138066184852857 7.76827909037416e-12 NA NA NA hsa-miR-429 HOXD1 2.84108892259147 3.88520896426515e-64 -0.254083939558569 0.0885179725940927 miRanda;miRNATAP -0.13036768292318 3.6086577165209e-06 NA NA NA hsa-miR-335-5p HPDL -2.61355235628987 2.6462884165886e-51 0.970313379779714 1.73895017429189e-05 miRNAWalker2_validate -0.202144237857937 1.46218898481266e-06 NA NA NA hsa-miR-375 HPDL 2.09893673049766 1.68351780396203e-16 0.970313379779714 1.73895017429189e-05 miRanda -0.25897928289724 1.02517702938508e-18 NA NA NA hsa-miR-139-5p HPRT1 -3.25846663863766 2.62018989415003e-112 1.02877146398302 3.1666016799026e-36 miRanda -0.235789461457539 1.63937413015852e-45 NA NA NA hsa-miR-21-5p HPS5 2.32007501846389 3.08394781855554e-137 -0.803820683819271 1.17995177352408e-34 miRNAWalker2_validate -0.232535808424181 9.50607346505541e-30 NA NA NA hsa-miR-337-3p HPSE -2.14274617598363 2.70942896809734e-43 0.77453554908944 1.60488527438354e-07 MirTarget -0.147235439629439 2.03503316458865e-06 NA NA NA hsa-miR-141-3p HS3ST3B1 2.99777540204168 1.26370498493024e-78 0.124324849124971 0.453118013962469 mirMAP -0.115159307276079 0.000340251230207572 NA NA NA hsa-miR-200a-3p HS3ST3B1 2.55218480823434 2.96135446816238e-51 0.124324849124971 0.453118013962469 mirMAP -0.11527944617107 0.00025621972639607 NA NA NA hsa-miR-429 HS3ST4 2.84108892259147 3.88520896426515e-64 -4.85986574348454 2.68361861028104e-51 miRNATAP -0.534950380119979 6.50663652378338e-17 NA NA NA hsa-miR-145-5p HS6ST1 -2.62703571936687 7.64402900188551e-88 0.788477247054106 1.86261413638323e-25 MirTarget;miRNATAP -0.194001835080178 1.41719502589613e-28 NA NA NA hsa-miR-335-5p HS6ST1 -2.61355235628987 2.6462884165886e-51 0.788477247054106 1.86261413638323e-25 mirMAP -0.119776483081542 3.36402403215525e-17 NA NA NA hsa-miR-429 HS6ST2 2.84108892259147 3.88520896426515e-64 -0.592962519537751 0.0172912803327558 miRanda;miRNATAP -0.105144839807421 0.026133374915561 NA NA NA hsa-miR-224-5p HS6ST3 -2.22249420723892 1.07787949391113e-18 1.50786338308735 1.14823254346702e-05 MirTarget -0.331132200847354 2.79506841971763e-13 NA NA NA hsa-miR-511-5p HSD11B2 -2.27545475897362 3.84085514050558e-36 1.12259313243163 1.40040762427312e-14 MirTarget -0.228658999858402 5.73042723022442e-18 NA NA NA hsa-miR-21-3p HSD17B11 2.17476065946878 5.15299442583591e-75 -1.40553615487301 2.63701740650701e-41 MirTarget -0.201976777445988 1.56682816915807e-12 NA NA NA hsa-miR-375 HSD17B13 2.09893673049766 1.68351780396203e-16 -5.42193557571211 3.45339215058616e-118 miRanda -0.265248259216041 6.72111429659138e-14 NA NA NA hsa-miR-21-5p HSD17B4 2.32007501846389 3.08394781855554e-137 -0.304028705746895 0.000256791454074577 MirTarget -0.158578636640685 7.31157763697113e-10 NA NA NA hsa-miR-139-5p HSD17B7 -3.25846663863766 2.62018989415003e-112 1.2906908925417 4.09344468976536e-46 miRanda -0.227699988520794 3.31384909128649e-33 NA NA NA hsa-miR-335-5p HSD17B7 -2.61355235628987 2.6462884165886e-51 1.2906908925417 4.09344468976536e-46 miRNAWalker2_validate -0.122795116004756 2.98494621453048e-12 NA NA NA hsa-miR-378a-5p HSD3B7 -2.43173551693523 1.44932837789175e-68 0.582526320725546 1.17538544982418e-09 mirMAP -0.192442714420204 2.59859451439379e-19 NA NA NA hsa-miR-335-5p HSH2D -2.61355235628987 2.6462884165886e-51 2.29099576090368 4.09626753089711e-32 miRNAWalker2_validate -0.252282394576823 1.07939370938819e-11 NA NA NA hsa-miR-139-5p HSP90AB2P -3.25846663863766 2.62018989415003e-112 0.560724180231676 1.80070588875642e-05 miRanda -0.128198512400931 1.91072517360306e-06 NA NA NA hsa-miR-429 HSPA12A 2.84108892259147 3.88520896426515e-64 -1.59429422829621 2.19664751982594e-36 miRanda -0.316022072647901 5.94845984096736e-40 NA NA NA hsa-miR-139-5p HSPA14 -3.25846663863766 2.62018989415003e-112 0.535120679179969 1.79503037080885e-16 miRanda -0.13612845769792 7.34579722551471e-25 NA NA NA hsa-miR-335-5p HSPA1A -2.61355235628987 2.6462884165886e-51 0.650265491816123 1.60469692704019e-09 miRNAWalker2_validate -0.106074197289326 1.29519353600891e-07 NA NA NA hsa-miR-10b-5p HSPA1B -2.10996264627796 7.36811595736367e-72 0.487404167271908 3.10487024426853e-07 miRNAWalker2_validate -0.186926841902028 1.16037013127619e-13 NA NA NA hsa-miR-335-5p HSPA5 -2.61355235628987 2.6462884165886e-51 0.767766990132028 2.90219682468348e-32 miRNAWalker2_validate -0.101154848499195 2.09130128824014e-16 NA NA NA hsa-miR-429 HSPB8 2.84108892259147 3.88520896426515e-64 -1.32168585350934 3.95234338629617e-09 miRanda -0.27178142614615 1.64426759035411e-10 NA NA NA hsa-miR-429 HSPG2 2.84108892259147 3.88520896426515e-64 -0.663529023393039 1.24284956805645e-10 miRNATAP -0.216652202279085 6.00823849322601e-30 NA NA NA hsa-miR-139-5p HSPH1 -3.25846663863766 2.62018989415003e-112 0.791359783601918 1.65635208983547e-18 miRanda -0.204826952010597 4.78359884507935e-29 NA NA NA hsa-miR-335-5p HTR1D -2.61355235628987 2.6462884165886e-51 2.99622149005401 1.17435878722818e-40 miRNAWalker2_validate -0.326900494377948 4.05353970004384e-14 NA NA NA hsa-miR-429 HTR1F 2.84108892259147 3.88520896426515e-64 -1.11679468328546 7.09774178155851e-13 miRanda -0.230445998211899 4.85582219764628e-15 NA NA NA hsa-miR-141-3p HTR2A 2.99777540204168 1.26370498493024e-78 -3.25271640549639 1.50870378512719e-45 TargetScan -0.594628497011561 8.62716545110525e-40 NA NA NA hsa-miR-183-5p HTR2A 2.95681814393872 1.09965777344285e-92 -3.25271640549639 1.50870378512719e-45 MirTarget -0.612287836731619 1.06971842274134e-35 NA NA NA hsa-miR-200b-3p HTR2A 2.11744072703209 1.66710572104191e-43 -3.25271640549639 1.50870378512719e-45 MirTarget -0.460179718567547 7.53887069674351e-20 NA NA NA hsa-miR-200c-3p HTR2A 2.07038651806183 6.84613386286599e-51 -3.25271640549639 1.50870378512719e-45 MirTarget -0.550786515734788 1.9952632069648e-23 NA NA NA hsa-miR-429 HTR2A 2.84108892259147 3.88520896426515e-64 -3.25271640549639 1.50870378512719e-45 MirTarget -0.498205800168983 4.44361596697947e-29 NA NA NA hsa-miR-429 HTR2B 2.84108892259147 3.88520896426515e-64 -0.472881103690154 0.00364556309074423 miRanda -0.24519226591876 6.43723409944212e-16 NA NA NA hsa-miR-335-5p HTRA4 -2.61355235628987 2.6462884165886e-51 1.45262722940668 7.37910997958679e-14 miRNAWalker2_validate -0.174307315513655 1.77233195502243e-06 NA NA NA hsa-miR-141-5p HUNK 2.38411349683216 4.56310582620282e-58 -1.41437716129914 2.840058273601e-14 mirMAP -0.261495565367427 7.64573084021878e-11 NA NA NA hsa-miR-200b-3p HUNK 2.11744072703209 1.66710572104191e-43 -1.41437716129914 2.840058273601e-14 mirMAP -0.290741115563636 1.96858395645014e-13 NA NA NA hsa-miR-200c-3p HUNK 2.07038651806183 6.84613386286599e-51 -1.41437716129914 2.840058273601e-14 mirMAP -0.289605836490056 3.15184386672616e-11 NA NA NA hsa-miR-429 HUNK 2.84108892259147 3.88520896426515e-64 -1.41437716129914 2.840058273601e-14 mirMAP -0.252516434884103 9.1060961662445e-13 NA NA NA hsa-miR-335-5p HYOU1 -2.61355235628987 2.6462884165886e-51 0.795136693904625 1.40743054734961e-24 miRNAWalker2_validate -0.135498595033891 9.83313127662431e-21 NA NA NA hsa-miR-139-5p IBSP -3.25846663863766 2.62018989415003e-112 5.71906594628957 7.23332970679324e-78 miRanda -1.07512158184459 1.20501314576614e-62 NA NA NA hsa-miR-429 ICA1L 2.84108892259147 3.88520896426515e-64 -0.877955917086615 5.40341328750603e-12 PITA;miRanda;miRNATAP -0.118536106853023 1.09176715763693e-06 NA NA NA hsa-miR-10b-5p ICOSLG -2.10996264627796 7.36811595736367e-72 0.381688318854728 0.000107916574437045 mirMAP -0.127309602769731 1.20618131112881e-06 NA NA NA hsa-miR-21-5p IDS 2.32007501846389 3.08394781855554e-137 -0.419749334741375 5.87554268885327e-10 mirMAP -0.103158307050403 1.14782006532718e-06 NA NA NA hsa-miR-139-5p IER3IP1 -3.25846663863766 2.62018989415003e-112 0.604920518994583 2.1423272060541e-21 miRanda -0.129968183974257 2.66930769904922e-23 NA NA NA hsa-miR-141-3p IFFO2 2.99777540204168 1.26370498493024e-78 -1.48770908138493 6.98625747312425e-36 MirTarget;TargetScan -0.125128329938908 1.93296816530002e-07 NA NA NA hsa-miR-429 IFNGR1 2.84108892259147 3.88520896426515e-64 -0.961189876051381 7.90304490354532e-39 miRNATAP -0.144785440240118 2.7420484507758e-24 NA NA NA hsa-miR-429 IGDCC3 2.84108892259147 3.88520896426515e-64 -0.822101785150693 0.0199324769312073 miRNATAP -0.142955974352798 0.0329655345729999 NA NA NA hsa-miR-141-3p IGDCC4 2.99777540204168 1.26370498493024e-78 -0.510415377148981 0.000190814880341201 TargetScan;miRNATAP -0.298483749014646 3.60076080217856e-31 NA NA NA hsa-miR-183-5p IGDCC4 2.95681814393872 1.09965777344285e-92 -0.510415377148981 0.000190814880341201 mirMAP -0.228653682540297 9.03469384765216e-16 NA NA NA hsa-miR-200a-3p IGDCC4 2.55218480823434 2.96135446816238e-51 -0.510415377148981 0.000190814880341201 miRNATAP -0.24365222055875 1.43769952394525e-21 NA NA NA hsa-miR-429 IGDCC4 2.84108892259147 3.88520896426515e-64 -0.510415377148981 0.000190814880341201 miRanda -0.20657668785035 6.34203447626757e-16 NA NA NA hsa-miR-224-5p IGF1R -2.22249420723892 1.07787949391113e-18 0.118209603036572 0.482168850037006 mirMAP -0.262380884793216 2.0900858366331e-34 NA NA NA hsa-miR-378a-5p IGF1R -2.43173551693523 1.44932837789175e-68 0.118209603036572 0.482168850037006 mirMAP -0.366238005092466 5.06012393985433e-23 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-452-5p IGF1R -2.48486455572568 1.24430987974325e-33 0.118209603036572 0.482168850037006 mirMAP -0.344176900884078 2.14757949011712e-41 NA NA NA hsa-miR-141-3p IGF2 2.99777540204168 1.26370498493024e-78 -1.80707502143834 9.64580354953106e-21 MirTarget;TargetScan -0.526450181465424 1.71357013794482e-47 NA NA NA hsa-miR-200a-3p IGF2 2.55218480823434 2.96135446816238e-51 -1.80707502143834 9.64580354953106e-21 MirTarget -0.43049563526396 2.80291025727271e-32 NA NA NA hsa-miR-210-3p IGF2 2.38367203491819 3.73261999106754e-22 -1.80707502143834 9.64580354953106e-21 MirTarget -0.334005796953098 7.04725823217349e-39 NA NA NA hsa-miR-335-5p IGF2BP1 -2.61355235628987 2.6462884165886e-51 2.12244186614741 1.81788912332828e-16 mirMAP -0.359299578773651 8.40427119301322e-14 NA NA NA hsa-miR-141-3p IGF2BP2 2.99777540204168 1.26370498493024e-78 -2.09056613546731 8.03883357755438e-21 MirTarget;TargetScan;miRNATAP -0.308964954035836 2.13564123840852e-12 NA NA NA hsa-miR-141-5p IGF2BP2 2.38411349683216 4.56310582620282e-58 -2.09056613546731 8.03883357755438e-21 miRNATAP -0.377011250735102 6.99412472720798e-15 NA NA NA hsa-miR-200a-3p IGF2BP2 2.55218480823434 2.96135446816238e-51 -2.09056613546731 8.03883357755438e-21 MirTarget;miRNATAP -0.253487183920497 4.95008082409817e-09 NA NA NA hsa-miR-375 IGF2BP2 2.09893673049766 1.68351780396203e-16 -2.09056613546731 8.03883357755438e-21 miRanda -0.398516176705958 4.44746556432504e-44 NA NA NA hsa-miR-429 IGF2BP2 2.84108892259147 3.88520896426515e-64 -2.09056613546731 8.03883357755438e-21 miRNATAP -0.188958277958729 1.24039017638879e-05 NA NA NA hsa-miR-200b-3p IGF2R 2.11744072703209 1.66710572104191e-43 -0.348661109166449 1.03155679185794e-05 MirTarget;TargetScan -0.13068413320337 3.00896491647488e-15 NA NA NA hsa-miR-200c-3p IGF2R 2.07038651806183 6.84613386286599e-51 -0.348661109166449 1.03155679185794e-05 MirTarget -0.129727939408734 1.26293466668871e-12 NA NA NA hsa-miR-375 IGFBP3 2.09893673049766 1.68351780396203e-16 -0.740251117224754 7.69399599791541e-12 miRNAWalker2_validate -0.125007540214907 9.99564454514586e-19 NA NA NA hsa-miR-141-5p IGFBP5 2.38411349683216 4.56310582620282e-58 -0.624288440197653 0.00100115978565398 mirMAP -0.214685523906588 1.24635646638894e-07 NA NA NA hsa-miR-200a-5p IGFBP5 2.58844508672328 1.79650654234569e-56 -0.624288440197653 0.00100115978565398 mirMAP -0.166306102683652 7.01342657556701e-06 NA NA NA hsa-miR-429 IGFBP5 2.84108892259147 3.88520896426515e-64 -0.624288440197653 0.00100115978565398 miRNATAP -0.18929517653133 1.25470334001011e-07 NA NA NA hsa-miR-10b-5p IGLON5 -2.10996264627796 7.36811595736367e-72 -0.031665071950719 0.874064061287377 mirMAP -0.139085908427463 0.00896463648170838 NA NA NA hsa-miR-429 IGLON5 2.84108892259147 3.88520896426515e-64 -0.031665071950719 0.874064061287377 miRNATAP -0.116947395756097 0.00197332120176978 NA NA NA hsa-miR-429 IGSF1 2.84108892259147 3.88520896426515e-64 -2.75241739689375 2.41513328950508e-14 miRanda -0.304477195282934 1.10401180173573e-05 NA NA NA hsa-miR-182-5p IGSF10 2.36408084103818 2.60011457600281e-72 -3.95227744371027 3.36497452938838e-68 MirTarget -0.764521292720942 1.21957427864894e-42 NA NA NA hsa-miR-200b-3p IGSF10 2.11744072703209 1.66710572104191e-43 -3.95227744371027 3.36497452938838e-68 MirTarget -0.635794894993236 6.65294331325235e-37 NA NA NA hsa-miR-200c-3p IGSF10 2.07038651806183 6.84613386286599e-51 -3.95227744371027 3.36497452938838e-68 MirTarget -0.719182726273409 3.59735727846842e-39 NA NA NA hsa-miR-429 IGSF10 2.84108892259147 3.88520896426515e-64 -3.95227744371027 3.36497452938838e-68 MirTarget -0.624317947700322 3.41977962536991e-45 NA NA NA hsa-miR-335-5p IGSF21 -2.61355235628987 2.6462884165886e-51 0.121418734542418 0.608638635922562 miRNAWalker2_validate -0.115141742650382 0.0089408375889396 NA NA NA hsa-miR-378a-5p IGSF3 -2.43173551693523 1.44932837789175e-68 0.889266392741621 3.34886421336615e-15 miRNAWalker2_validate -0.13986313508489 6.15695311516531e-08 NA NA NA hsa-miR-486-5p IGSF3 -3.87258704301474 1.22658629378451e-80 0.889266392741621 3.34886421336615e-15 miRanda -0.176008935095912 2.75651893552516e-25 NA NA NA hsa-miR-486-5p IGSF9 -3.87258704301474 1.22658629378451e-80 2.7815506442964 4.49434339377106e-63 miRanda -0.386444188594594 2.15652877996595e-51 NA NA NA hsa-miR-182-5p IKZF1 2.36408084103818 2.60011457600281e-72 -0.00939384968032098 0.945397957833694 mirMAP -0.158944383756935 1.00256776085576e-06 NA NA NA hsa-miR-96-5p IKZF3 3.24596558166606 1.92296159041707e-98 -0.177481122337582 0.471002859089698 TargetScan -0.132087944427676 0.00664143287745469 NA NA NA hsa-miR-182-5p IL16 2.36408084103818 2.60011457600281e-72 -0.654582380588762 1.0795525574358e-08 mirMAP -0.223884357917741 1.17917700107769e-16 NA NA NA hsa-miR-182-5p IL17RA 2.36408084103818 2.60011457600281e-72 -0.37270079555394 4.15806606736038e-08 mirMAP -0.134708472606439 3.7060510850022e-17 NA NA NA hsa-miR-182-5p IL17RD 2.36408084103818 2.60011457600281e-72 -1.72855770649746 1.16696773701473e-33 mirMAP -0.217067838916572 6.94772959632167e-10 NA NA NA hsa-miR-21-3p IL17RD 2.17476065946878 5.15299442583591e-75 -1.72855770649746 1.16696773701473e-33 mirMAP -0.37521751748468 9.66013656235158e-23 NA NA NA hsa-miR-429 IL17RD 2.84108892259147 3.88520896426515e-64 -1.72855770649746 1.16696773701473e-33 miRNATAP -0.14792664184902 1.35428662019868e-07 NA NA NA hsa-miR-96-5p IL17RD 3.24596558166606 1.92296159041707e-98 -1.72855770649746 1.16696773701473e-33 mirMAP -0.225201632437216 8.3789059655566e-15 NA NA NA hsa-miR-335-5p IL17REL -2.61355235628987 2.6462884165886e-51 2.03300274598664 6.45624109468816e-17 mirMAP -0.238334282739905 2.00297750732176e-07 NA NA NA hsa-miR-378a-5p IL17REL -2.43173551693523 1.44932837789175e-68 2.03300274598664 6.45624109468816e-17 mirMAP -0.402178621839568 4.07789892242418e-13 NA NA NA hsa-miR-141-3p IL18R1 2.99777540204168 1.26370498493024e-78 -0.690005437517726 7.21646874091323e-07 MirTarget -0.223862252764291 5.72319233427833e-17 NA NA NA hsa-miR-200a-3p IL18R1 2.55218480823434 2.96135446816238e-51 -0.690005437517726 7.21646874091323e-07 MirTarget -0.215151086528538 2.54766140173558e-16 NA NA NA hsa-miR-375 IL1RAP 2.09893673049766 1.68351780396203e-16 -0.759572369248282 5.03872337590099e-11 miRNAWalker2_validate;miRanda -0.111918762451102 1.90407427894537e-13 NA NA NA hsa-miR-335-5p IL21R -2.61355235628987 2.6462884165886e-51 2.59778925912353 5.84116459440323e-44 miRNAWalker2_validate -0.366295898138256 8.96485712037857e-25 NA NA NA hsa-miR-375 IL2RA 2.09893673049766 1.68351780396203e-16 0.552215139772291 0.00781659262634694 miRanda -0.226533685168416 3.8944695458836e-17 NA NA NA hsa-miR-429 IL33 2.84108892259147 3.88520896426515e-64 -3.84518732666552 1.19448116349764e-51 miRanda -0.567737920747655 2.50902667746104e-30 NA NA NA hsa-miR-429 IL6 2.84108892259147 3.88520896426515e-64 -3.07751927232311 9.9131162785608e-32 miRanda -0.424185146928772 6.81793191441461e-17 NA NA NA hsa-miR-141-3p IL6R 2.99777540204168 1.26370498493024e-78 -1.4959681212526 3.98690474593025e-23 MirTarget -0.253098258336402 1.27382588367647e-17 NA NA NA hsa-miR-141-5p IL6R 2.38411349683216 4.56310582620282e-58 -1.4959681212526 3.98690474593025e-23 MirTarget -0.211774282012291 1.43748300605942e-10 NA NA NA hsa-miR-182-5p IL6R 2.36408084103818 2.60011457600281e-72 -1.4959681212526 3.98690474593025e-23 mirMAP -0.379208971544044 4.41744748962182e-26 NA NA NA hsa-miR-200a-3p IL6R 2.55218480823434 2.96135446816238e-51 -1.4959681212526 3.98690474593025e-23 MirTarget -0.235380598297946 6.33404340334906e-16 NA NA NA hsa-miR-21-5p IL6R 2.32007501846389 3.08394781855554e-137 -1.4959681212526 3.98690474593025e-23 MirTarget;miRNATAP -0.329109136402319 6.05386734548003e-12 NA NA NA hsa-miR-200a-5p IL6ST 2.58844508672328 1.79650654234569e-56 -1.52737235369582 4.44388978309665e-09 mirMAP -0.10464824719269 0.0417048371069342 NA NA NA hsa-miR-200b-3p IL6ST 2.11744072703209 1.66710572104191e-43 -1.52737235369582 4.44388978309665e-09 TargetScan;mirMAP -0.261627924408914 2.44482742970634e-06 NA NA NA hsa-miR-200c-3p IL6ST 2.07038651806183 6.84613386286599e-51 -1.52737235369582 4.44388978309665e-09 mirMAP -0.317849621642354 1.84584384570656e-07 NA NA NA hsa-miR-21-5p IL6ST 2.32007501846389 3.08394781855554e-137 -1.52737235369582 4.44388978309665e-09 mirMAP -0.56765013906967 2.31975560408847e-12 NA NA NA hsa-miR-429 IL6ST 2.84108892259147 3.88520896426515e-64 -1.52737235369582 4.44388978309665e-09 PITA;miRanda;mirMAP;miRNATAP -0.326861790658869 3.22589396227134e-11 NA NA NA hsa-miR-452-5p IL6ST -2.48486455572568 1.24430987974325e-33 -1.52737235369582 4.44388978309665e-09 mirMAP -0.219664066998091 1.43869954863149e-07 NA NA NA hsa-miR-429 IL7 2.84108892259147 3.88520896426515e-64 -1.15623141298675 2.89787466175942e-14 miRanda -0.191776055201327 3.56427683831472e-11 NA NA NA hsa-miR-139-5p ILDR1 -3.25846663863766 2.62018989415003e-112 1.82087838830943 2.80837566468513e-34 miRanda -0.319843434280562 9.29492518227731e-25 NA NA NA hsa-miR-335-5p ILDR1 -2.61355235628987 2.6462884165886e-51 1.82087838830943 2.80837566468513e-34 miRNAWalker2_validate -0.19991798922184 2.57300615687315e-12 NA NA NA hsa-miR-139-5p INA -3.25846663863766 2.62018989415003e-112 1.4150014925926 7.79360475745636e-07 miRanda -0.44701677500829 2.09743756926182e-14 NA NA NA hsa-miR-21-5p ING3 2.32007501846389 3.08394781855554e-137 -0.74811083666521 2.30984186562665e-29 MirTarget -0.281229141739032 1.71801122931191e-43 NA NA NA hsa-miR-10b-5p INHBA -2.10996264627796 7.36811595736367e-72 2.92269165168259 7.0734436456195e-54 miRNAWalker2_validate -0.315991143995102 3.56059166646068e-09 NA NA NA hsa-miR-429 INHBB 2.84108892259147 3.88520896426515e-64 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.210500602533215 3.36016908073308e-12 NA NA NA hsa-miR-335-5p INO80B -2.61355235628987 2.6462884165886e-51 0.883784768455357 1.795929199568e-13 miRNAWalker2_validate -0.172366464102915 1.04141795022263e-14 NA NA NA hsa-miR-452-5p INPP4B -2.48486455572568 1.24430987974325e-33 -0.27727152513369 0.13578171859258 mirMAP -0.285594648215494 5.57157212691772e-23 NA NA NA hsa-miR-139-5p INSM1 -3.25846663863766 2.62018989415003e-112 2.53088848960554 1.5995992392203e-11 miRanda -0.375805879985493 1.4324964419775e-06 NA NA NA hsa-miR-99a-5p INSM1 -2.25079447371102 1.14086813185885e-54 2.53088848960554 1.5995992392203e-11 miRNATAP -0.667658651576773 7.83062481569597e-16 NA NA NA hsa-miR-21-5p INSR 2.32007501846389 3.08394781855554e-137 -0.27492376201698 0.000536820623484817 mirMAP -0.169950201921848 3.994162980573e-12 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-21-5p IPO11 2.32007501846389 3.08394781855554e-137 -0.289109997569103 3.26776379700959e-06 miRNATAP -0.139705222942741 3.16755395368817e-13 NA NA NA hsa-miR-139-5p IPO13 -3.25846663863766 2.62018989415003e-112 0.4707821907694 1.79290336123513e-19 miRanda -0.106341048113932 1.98278679777589e-23 NA NA NA hsa-miR-10b-5p IPO9 -2.10996264627796 7.36811595736367e-72 0.553239220279916 7.61322298585656e-21 mirMAP -0.145910212323481 1.8066934367131e-20 NA NA NA hsa-miR-21-5p IPP 2.32007501846389 3.08394781855554e-137 -0.324885964126803 0.000214503536915239 miRNAWalker2_validate -0.211076693212558 5.31244386744071e-15 NA NA NA hsa-miR-429 IPW 2.84108892259147 3.88520896426515e-64 -1.04160375124983 4.64527296250259e-13 miRanda -0.151034824209886 3.89411919285886e-08 NA NA NA hsa-miR-429 IQGAP2 2.84108892259147 3.88520896426515e-64 -0.833377249160647 3.75715509897957e-07 miRanda;miRNATAP -0.172531156395297 2.80186841128723e-08 NA NA NA hsa-miR-429 IQSEC1 2.84108892259147 3.88520896426515e-64 -0.61870304697525 5.16415663136319e-24 miRanda -0.134152988158333 1.33551344221439e-31 NA NA NA hsa-miR-429 IQUB 2.84108892259147 3.88520896426515e-64 -0.92779043179496 5.71315229122358e-06 miRanda -0.105759078177488 0.00662281804802406 NA NA NA hsa-miR-141-3p IRAK3 2.99777540204168 1.26370498493024e-78 -1.84214553446996 7.98016779710475e-32 mirMAP -0.395371091533372 5.07583894364656e-39 NA NA NA hsa-miR-200a-3p IRAK3 2.55218480823434 2.96135446816238e-51 -1.84214553446996 7.98016779710475e-32 mirMAP -0.318261128528154 5.73130945956319e-26 NA NA NA hsa-miR-21-5p IRAK3 2.32007501846389 3.08394781855554e-137 -1.84214553446996 7.98016779710475e-32 mirMAP -0.432949994242884 3.91318586050703e-18 NA NA NA hsa-miR-429 IRAK3 2.84108892259147 3.88520896426515e-64 -1.84214553446996 7.98016779710475e-32 miRanda -0.334670000939921 3.85801572773716e-29 NA NA NA hsa-miR-21-5p IREB2 2.32007501846389 3.08394781855554e-137 -0.452211887815269 8.87153351090651e-11 miRNAWalker2_validate -0.181574287669945 3.53247747736457e-17 NA NA NA hsa-miR-429 IRF4 2.84108892259147 3.88520896426515e-64 -1.1496672452986 1.0297026274575e-07 miRanda -0.222696170243832 5.47772663685885e-08 NA NA NA hsa-miR-144-5p IRF6 -2.75914786146772 1.55794225315972e-50 0.483282739095936 0.000196023194918427 MirTarget -0.133688174979 2.79648149252758e-09 NA NA NA hsa-miR-429 IRF8 2.84108892259147 3.88520896426515e-64 -0.123631542712002 0.357149289731711 miRanda -0.122909134408318 1.17800103504914e-06 NA NA NA hsa-miR-183-5p IRS1 2.95681814393872 1.09965777344285e-92 -1.09359999788168 5.90327201022502e-13 MirTarget;miRNATAP -0.199350251372208 5.75374286443932e-10 NA NA NA hsa-miR-200c-3p IRS1 2.07038651806183 6.84613386286599e-51 -1.09359999788168 5.90327201022502e-13 miRNATAP -0.176788257679081 7.61635995828395e-07 NA NA NA hsa-miR-429 IRS1 2.84108892259147 3.88520896426515e-64 -1.09359999788168 5.90327201022502e-13 miRanda;miRNATAP -0.162361096724304 2.09525237425462e-08 NA NA NA hsa-miR-96-5p IRS1 3.24596558166606 1.92296159041707e-98 -1.09359999788168 5.90327201022502e-13 MirTarget;TargetScan;miRNATAP -0.143349063007378 2.27407069359301e-06 21993544 hsa miR 96 up regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas; Altogether these results suggest that hsa-miR-96 may affect the growth of bladder cancer cells by up-regulating IRS1 and MAP4K1 levels functioning as a promising diagnostic marker in human bladder urothelial carcinomas bladder cancer hsa-miR-141-3p IRS2 2.99777540204168 1.26370498493024e-78 -1.8204216908965 4.33851273349302e-35 MirTarget;TargetScan;miRNATAP -0.235924790553112 1.04773628002177e-15 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2 metastasis thyroid cancer hsa-miR-200a-3p IRS2 2.55218480823434 2.96135446816238e-51 -1.8204216908965 4.33851273349302e-35 MirTarget;miRNATAP -0.175545744057414 1.60236179475126e-09 NA NA NA hsa-miR-429 IRS2 2.84108892259147 3.88520896426515e-64 -1.8204216908965 4.33851273349302e-35 PITA;miRanda;miRNATAP -0.251648825216138 1.1996991175766e-18 NA NA NA hsa-miR-486-5p IRX5 -3.87258704301474 1.22658629378451e-80 1.27988273774722 3.5275885850243e-25 PITA;miRanda;miRNATAP -0.186047938411587 5.11948950955527e-23 NA NA NA hsa-miR-375 IRX6 2.09893673049766 1.68351780396203e-16 -3.40348661387814 5.19317395535841e-39 miRanda -0.418916033296392 1.21922329078054e-33 NA NA NA hsa-miR-21-5p ISCU 2.32007501846389 3.08394781855554e-137 -0.474318624658276 2.67102425402634e-20 miRNAWalker2_validate;miRTarBase -0.14822383985227 1.75986348300615e-20 NA NA NA hsa-miR-335-5p ISG20 -2.61355235628987 2.6462884165886e-51 1.23537527113135 1.84969084634804e-20 miRNAWalker2_validate -0.182161950592566 3.36576454783204e-13 NA NA NA hsa-miR-429 ISM1 2.84108892259147 3.88520896426515e-64 -2.57871128096511 3.01143153083226e-49 miRanda -0.413082084679439 2.50563099970465e-34 NA NA NA hsa-miR-141-5p ITGA1 2.38411349683216 4.56310582620282e-58 -1.29512393000353 7.98953749577455e-27 MirTarget -0.256930514466659 7.45874120468767e-23 NA NA NA hsa-miR-200a-5p ITGA1 2.58844508672328 1.79650654234569e-56 -1.29512393000353 7.98953749577455e-27 mirMAP -0.217378046124112 7.48753974744995e-20 NA NA NA hsa-miR-200b-3p ITGA1 2.11744072703209 1.66710572104191e-43 -1.29512393000353 7.98953749577455e-27 MirTarget -0.315620670948116 1.43489959453689e-35 NA NA NA hsa-miR-200c-3p ITGA1 2.07038651806183 6.84613386286599e-51 -1.29512393000353 7.98953749577455e-27 MirTarget -0.346757618979074 1.67421615105689e-35 NA NA NA hsa-miR-21-5p ITGA1 2.32007501846389 3.08394781855554e-137 -1.29512393000353 7.98953749577455e-27 mirMAP -0.323092029358791 2.56001275037339e-17 NA NA NA hsa-miR-429 ITGA1 2.84108892259147 3.88520896426515e-64 -1.29512393000353 7.98953749577455e-27 MirTarget;miRanda -0.275342516757783 6.9727437361557e-34 NA NA NA hsa-miR-429 ITGA10 2.84108892259147 3.88520896426515e-64 -1.01261887152059 1.26964937815038e-09 miRanda;miRNATAP -0.157135433897949 7.48029071890922e-07 NA NA NA hsa-miR-183-5p ITGA8 2.95681814393872 1.09965777344285e-92 -1.33167258927312 3.90791960236807e-09 miRNAWalker2_validate -0.278281073234491 5.61678710347892e-09 NA NA NA hsa-miR-21-5p ITGA8 2.32007501846389 3.08394781855554e-137 -1.33167258927312 3.90791960236807e-09 mirMAP -0.342105492128526 1.37371548465133e-06 NA NA NA hsa-miR-141-5p ITGA9 2.38411349683216 4.56310582620282e-58 -1.80608575406488 8.11052269984858e-33 MirTarget -0.292946163417545 1.02122866661168e-18 NA NA NA hsa-miR-200b-3p ITGA9 2.11744072703209 1.66710572104191e-43 -1.80608575406488 8.11052269984858e-33 mirMAP -0.296491785199914 1.27602275062816e-19 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-429 ITGA9 2.84108892259147 3.88520896426515e-64 -1.80608575406488 8.11052269984858e-33 miRanda -0.312074908424021 3.8893701166445e-27 NA NA NA hsa-miR-141-3p ITGAV 2.99777540204168 1.26370498493024e-78 -0.0515028444394998 0.572303431365019 MirTarget -0.108251623223024 6.82325620061394e-10 NA NA NA hsa-miR-200a-3p ITGAV 2.55218480823434 2.96135446816238e-51 -0.0515028444394998 0.572303431365019 MirTarget -0.10013577528264 6.24202667621143e-09 NA NA NA hsa-miR-429 ITGAV 2.84108892259147 3.88520896426515e-64 -0.0515028444394998 0.572303431365019 miRanda -0.104635159336959 9.38637410830064e-10 NA NA NA hsa-miR-429 ITGB1 2.84108892259147 3.88520896426515e-64 -0.678317106156189 5.66194666134702e-21 miRanda -0.133174997661172 1.66767130152533e-22 NA NA NA hsa-miR-335-5p ITGB2 -2.61355235628987 2.6462884165886e-51 0.781200680713074 7.58249713982613e-10 miRNAWalker2_validate -0.15054300422263 1.7626731050026e-10 NA NA NA hsa-miR-429 ITGB3 2.84108892259147 3.88520896426515e-64 -1.34505322338581 2.68734688128446e-18 miRanda -0.310603398492102 6.39753034365381e-27 NA NA NA hsa-miR-378a-5p ITGB5 -2.43173551693523 1.44932837789175e-68 0.194292620009985 0.0495928541847793 MirTarget -0.136596769908688 7.57897389611419e-10 NA NA NA hsa-miR-182-5p ITGB8 2.36408084103818 2.60011457600281e-72 -1.12696988747201 4.22273879817388e-08 MirTarget -0.211281431029455 1.77955245600773e-05 NA NA NA hsa-miR-183-5p ITGB8 2.95681814393872 1.09965777344285e-92 -1.12696988747201 4.22273879817388e-08 MirTarget -0.18162729391263 3.05273919450045e-05 NA NA NA hsa-miR-486-5p ITGBL1 -3.87258704301474 1.22658629378451e-80 0.315798458346912 0.0426184757699523 miRanda -0.110998998678364 2.48948292552868e-06 NA NA NA hsa-miR-429 ITIH3 2.84108892259147 3.88520896426515e-64 -1.68540818350616 3.63971662762248e-17 miRNATAP -0.352198450145988 1.13755716192444e-20 NA NA NA hsa-miR-375 ITM2A 2.09893673049766 1.68351780396203e-16 -2.75204265899877 9.55524540055346e-61 miRanda -0.166828706307385 1.38483195233048e-12 NA NA NA hsa-miR-429 ITM2A 2.84108892259147 3.88520896426515e-64 -2.75204265899877 9.55524540055346e-61 miRanda -0.448077302083026 2.57573306139109e-43 NA NA NA hsa-miR-200b-3p ITM2B 2.11744072703209 1.66710572104191e-43 -0.774118134449479 1.44766521128185e-32 TargetScan -0.12915238374822 3.58954933480469e-20 NA NA NA hsa-miR-429 ITM2B 2.84108892259147 3.88520896426515e-64 -0.774118134449479 1.44766521128185e-32 PITA;miRanda -0.136198783031976 4.87058538056931e-28 NA NA NA hsa-miR-182-5p ITPKB 2.36408084103818 2.60011457600281e-72 -0.460580394185294 4.22060681622517e-09 mirMAP -0.12957120616928 3.31173954764598e-12 NA NA NA hsa-miR-183-5p ITPKB 2.95681814393872 1.09965777344285e-92 -0.460580394185294 4.22060681622517e-09 miRNAWalker2_validate -0.117744811979666 7.9999807501685e-13 NA NA NA hsa-miR-182-5p ITPR1 2.36408084103818 2.60011457600281e-72 -1.46807554682214 2.21759203162078e-22 miRNATAP -0.111883033753082 0.00243567584814263 NA NA NA hsa-miR-200b-3p ITPR1 2.11744072703209 1.66710572104191e-43 -1.46807554682214 2.21759203162078e-22 TargetScan -0.152946773039534 2.9772888212609e-06 NA NA NA hsa-miR-200c-3p ITPR1 2.07038651806183 6.84613386286599e-51 -1.46807554682214 2.21759203162078e-22 miRNATAP -0.183187577943365 3.48180608913953e-07 NA NA NA hsa-miR-224-5p ITPR1 -2.22249420723892 1.07787949391113e-18 -1.46807554682214 2.21759203162078e-22 MirTarget -0.112218610852405 4.23785403321903e-08 NA NA NA hsa-miR-429 ITPR1 2.84108892259147 3.88520896426515e-64 -1.46807554682214 2.21759203162078e-22 PITA;miRanda;miRNATAP -0.221082891608417 2.08697642192612e-14 NA NA NA hsa-miR-96-5p ITPR1 3.24596558166606 1.92296159041707e-98 -1.46807554682214 2.21759203162078e-22 MirTarget;TargetScan;miRNATAP -0.212836309721477 2.02931396055187e-12 NA NA NA hsa-miR-96-5p ITPR2 3.24596558166606 1.92296159041707e-98 -0.979435994319307 6.70245773649528e-14 MirTarget;TargetScan -0.138399600173943 1.12525120611339e-07 NA NA NA hsa-miR-141-5p ITPRIP 2.38411349683216 4.56310582620282e-58 -0.576110389061243 2.09810469876649e-10 MirTarget -0.182365760703905 2.16533951813753e-21 NA NA NA hsa-miR-141-3p ITSN1 2.99777540204168 1.26370498493024e-78 -1.54952456784757 2.98389839982187e-72 TargetScan;mirMAP -0.314671826600494 3.57030031689501e-80 NA NA NA hsa-miR-141-5p ITSN1 2.38411349683216 4.56310582620282e-58 -1.54952456784757 2.98389839982187e-72 mirMAP -0.293799055056286 3.49179280498103e-54 NA NA NA hsa-miR-182-5p ITSN1 2.36408084103818 2.60011457600281e-72 -1.54952456784757 2.98389839982187e-72 mirMAP -0.277516367603621 3.28911608555395e-38 NA NA NA hsa-miR-200a-3p ITSN1 2.55218480823434 2.96135446816238e-51 -1.54952456784757 2.98389839982187e-72 mirMAP -0.281702036352308 1.61598821068158e-64 NA NA NA hsa-miR-200a-5p ITSN1 2.58844508672328 1.79650654234569e-56 -1.54952456784757 2.98389839982187e-72 mirMAP -0.251687938947879 1.72693704832268e-47 NA NA NA hsa-miR-200b-3p ITSN1 2.11744072703209 1.66710572104191e-43 -1.54952456784757 2.98389839982187e-72 TargetScan -0.304186437686147 2.8057181100831e-60 NA NA NA hsa-miR-429 ITSN1 2.84108892259147 3.88520896426515e-64 -1.54952456784757 2.98389839982187e-72 PITA;miRanda;miRNATAP -0.265339530551666 3.72765088709456e-57 NA NA NA hsa-miR-96-5p ITSN1 3.24596558166606 1.92296159041707e-98 -1.54952456784757 2.98389839982187e-72 mirMAP -0.274640843270841 4.44788306199299e-56 NA NA NA hsa-miR-21-5p ITSN2 2.32007501846389 3.08394781855554e-137 -0.528200393057157 3.69758362551338e-16 miRNAWalker2_validate -0.177512416339358 1.14681317030502e-18 NA NA NA hsa-miR-335-5p IVL -2.61355235628987 2.6462884165886e-51 1.85937735719492 5.40320835835149e-08 miRNAWalker2_validate -0.394266719098811 5.23573646097459e-10 NA NA NA hsa-miR-335-5p IYD -2.61355235628987 2.6462884165886e-51 1.0768314494353 0.00194895475806759 miRNAWalker2_validate -0.128836961800067 0.0467816079983686 NA NA NA hsa-miR-141-3p JAG1 2.99777540204168 1.26370498493024e-78 -0.639848689982383 1.267264807356e-11 TargetScan;miRNATAP -0.181143197005444 1.3218035421414e-23 NA NA NA hsa-miR-200a-3p JAG1 2.55218480823434 2.96135446816238e-51 -0.639848689982383 1.267264807356e-11 miRNATAP -0.158129060319048 8.46880611870666e-19 NA NA NA hsa-miR-200c-3p JAG1 2.07038651806183 6.84613386286599e-51 -0.639848689982383 1.267264807356e-11 miRNAWalker2_validate -0.198884904510323 7.69822940625124e-20 NA NA NA hsa-miR-21-5p JAG1 2.32007501846389 3.08394781855554e-137 -0.639848689982383 1.267264807356e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.129114979011453 1.3818320929806e-05 NA NA NA hsa-miR-429 JAG1 2.84108892259147 3.88520896426515e-64 -0.639848689982383 1.267264807356e-11 miRanda -0.175864382531487 1.95428509436245e-23 NA NA NA hsa-miR-335-5p JAKMIP1 -2.61355235628987 2.6462884165886e-51 2.59421950072785 4.752218280853e-28 miRNAWalker2_validate -0.28806729503774 1.52805343753955e-10 NA NA NA hsa-miR-139-5p JAKMIP2 -3.25846663863766 2.62018989415003e-112 0.956110224631622 1.13857553722835e-07 MirTarget -0.248100257483352 1.97971513775791e-11 NA NA NA hsa-miR-335-5p JAKMIP2 -2.61355235628987 2.6462884165886e-51 0.956110224631622 1.13857553722835e-07 miRNAWalker2_validate -0.191870379789592 1.01841010010462e-08 NA NA NA hsa-miR-429 JAM2 2.84108892259147 3.88520896426515e-64 -2.19629863351784 5.61282106248999e-65 miRNATAP -0.404291199620708 1.09568043719551e-60 NA NA NA hsa-miR-183-5p JAM3 2.95681814393872 1.09965777344285e-92 -1.28519944420703 1.56289681820033e-35 MirTarget -0.298238484006266 1.64253749641454e-43 NA NA NA hsa-miR-10b-5p JARID2 -2.10996264627796 7.36811595736367e-72 0.581004002397887 3.75615851610388e-17 MirTarget;miRNATAP -0.124199696836171 2.01196138377667e-11 NA NA NA hsa-miR-139-5p JARID2 -3.25846663863766 2.62018989415003e-112 0.581004002397887 3.75615851610388e-17 miRanda -0.114139425400079 1.03557985025542e-15 NA NA NA hsa-miR-141-3p JAZF1 2.99777540204168 1.26370498493024e-78 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.218487624704801 5.75457071465146e-47 NA NA NA hsa-miR-182-5p JAZF1 2.36408084103818 2.60011457600281e-72 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.236976508633793 3.67762615895074e-36 NA NA NA hsa-miR-200a-3p JAZF1 2.55218480823434 2.96135446816238e-51 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.18737143018996 2.98029984108802e-35 NA NA NA hsa-miR-200b-3p JAZF1 2.11744072703209 1.66710572104191e-43 -0.923990464641291 4.60180562998007e-31 MirTarget;TargetScan -0.21708530697461 2.07737411492899e-38 NA NA NA hsa-miR-200c-3p JAZF1 2.07038651806183 6.84613386286599e-51 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.274951933132508 3.73724958148104e-52 NA NA NA hsa-miR-429 JAZF1 2.84108892259147 3.88520896426515e-64 -0.923990464641291 4.60180562998007e-31 MirTarget;PITA;miRanda;miRNATAP -0.185671474855367 4.3768275839721e-35 NA NA NA hsa-miR-96-5p JAZF1 3.24596558166606 1.92296159041707e-98 -0.923990464641291 4.60180562998007e-31 miRNAWalker2_validate;MirTarget;TargetScan -0.198644361059771 6.0686595968077e-37 NA NA NA hsa-miR-21-3p JDP2 2.17476065946878 5.15299442583591e-75 -0.455398242183343 1.31110011087385e-06 mirMAP -0.137707917879422 2.60592400693317e-08 NA NA NA hsa-miR-141-3p JMJD1C 2.99777540204168 1.26370498493024e-78 -0.953909284202117 8.88053084204105e-27 TargetScan;miRNATAP -0.112751286313442 1.87607549342718e-10 NA NA NA hsa-miR-182-5p JMJD1C 2.36408084103818 2.60011457600281e-72 -0.953909284202117 8.88053084204105e-27 miRNATAP -0.127362934494291 4.62242543519682e-09 NA NA NA hsa-miR-200a-3p JMJD1C 2.55218480823434 2.96135446816238e-51 -0.953909284202117 8.88053084204105e-27 miRNATAP -0.101250305321967 5.88454545475261e-09 NA NA NA hsa-miR-96-5p JMJD1C 3.24596558166606 1.92296159041707e-98 -0.953909284202117 8.88053084204105e-27 TargetScan;miRNATAP -0.138144756521608 1.18602906203182e-14 NA NA NA hsa-miR-21-3p JMY 2.17476065946878 5.15299442583591e-75 -0.711397270609706 9.16652222896492e-21 mirMAP -0.117265354476185 8.44571789816432e-09 NA NA NA hsa-miR-21-5p JMY 2.32007501846389 3.08394781855554e-137 -0.711397270609706 9.16652222896492e-21 miRNAWalker2_validate;mirMAP -0.235903321169589 1.92593672468556e-23 NA NA NA hsa-miR-145-5p JPH1 -2.62703571936687 7.64402900188551e-88 0.811793520985586 6.62203604379622e-06 miRNATAP -0.191870753350915 4.69666939147425e-06 NA NA NA hsa-miR-99a-5p JPH1 -2.25079447371102 1.14086813185885e-54 0.811793520985586 6.62203604379622e-06 miRNAWalker2_validate -0.171387474570096 1.82665226020618e-05 NA NA NA hsa-miR-429 JPH2 2.84108892259147 3.88520896426515e-64 -2.70729173750039 1.39103454528235e-42 miRNATAP -0.352567970303692 8.06335901474151e-20 NA NA NA hsa-miR-139-5p JPH3 -3.25846663863766 2.62018989415003e-112 1.09335026757806 1.5377591231963e-07 miRanda -0.218849692891221 3.54105772588278e-07 NA NA NA hsa-miR-429 JPH4 2.84108892259147 3.88520896426515e-64 -1.24380620289051 5.28327009593929e-20 miRNATAP -0.241009136038358 7.43820550544951e-21 NA NA NA hsa-miR-141-3p JUN 2.99777540204168 1.26370498493024e-78 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.26513026030347 4.33514873445987e-29 NA NA NA hsa-miR-155-5p JUN 1.09766314984151 4.55650930885814e-15 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate;miRTarBase -0.151050894850655 5.76726631886013e-07 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-15a-5p JUN 0.812445324157528 4.50263417099822e-20 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.11719036255872 0.0145941714826506 NA NA NA hsa-miR-16-5p JUN 0.46835991343556 1.91125356547776e-06 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.336111932326481 7.47849859844435e-15 NA NA NA hsa-miR-200a-3p JUN 2.55218480823434 2.96135446816238e-51 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.179081800592841 4.16743748553287e-14 NA NA NA hsa-miR-200b-3p JUN 2.11744072703209 1.66710572104191e-43 -1.36309173493779 4.05020743854001e-29 MirTarget;TargetScan -0.16460620647419 5.28647088864828e-10 NA NA NA hsa-miR-200c-3p JUN 2.07038651806183 6.84613386286599e-51 -1.36309173493779 4.05020743854001e-29 MirTarget -0.273188681953389 1.78966606345752e-21 NA NA NA hsa-miR-32-5p JUN 1.38676603945192 2.29428299685976e-34 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.263951179853313 2.73587232573327e-13 NA NA NA hsa-miR-342-3p JUN 1.21944481975657 6.81914373001202e-19 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.199604605467411 5.91888161762324e-11 NA NA NA hsa-miR-429 JUN 2.84108892259147 3.88520896426515e-64 -1.36309173493779 4.05020743854001e-29 MirTarget;PITA;miRanda;miRNATAP -0.17100165827497 4.02284319393828e-13 NA NA NA hsa-miR-455-3p JUN 0.678392920628872 0.000327758844555877 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.147720631567845 5.98195601818343e-11 NA NA NA hsa-miR-590-3p JUN 1.27438512890514 1.03164723481469e-23 -1.36309173493779 4.05020743854001e-29 miRanda -0.306481168731635 1.59764946185952e-19 NA NA NA hsa-miR-92a-3p JUN -0.342420481092807 0.000732275969501111 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.138285339206201 0.00119119178853874 NA NA NA hsa-miR-92b-3p JUN 1.30248132773644 9.42428674470985e-25 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.135248670230231 4.27496884553493e-05 NA NA NA hsa-miR-93-5p JUN 1.01788600209314 1.24312921618126e-21 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.216264935663652 4.08318210776355e-08 NA NA NA hsa-miR-335-5p JUP -2.61355235628987 2.6462884165886e-51 0.838019417350591 2.85591243483582e-25 miRNAWalker2_validate -0.106047531124234 3.61551546916669e-12 NA NA NA hsa-miR-375 KALRN 2.09893673049766 1.68351780396203e-16 -1.5107223055413 2.88107495352718e-31 miRanda -0.148727875355044 1.66710211320528e-17 NA NA NA hsa-miR-429 KALRN 2.84108892259147 3.88520896426515e-64 -1.5107223055413 2.88107495352718e-31 miRanda;miRNATAP -0.208045979386821 1.18832710602525e-16 NA NA NA hsa-miR-200b-3p KANK1 2.11744072703209 1.66710572104191e-43 -2.04494589285398 6.14282151736161e-68 MirTarget;TargetScan -0.225785663199898 2.27973124550979e-17 NA NA NA hsa-miR-200c-3p KANK1 2.07038651806183 6.84613386286599e-51 -2.04494589285398 6.14282151736161e-68 MirTarget -0.286218542079834 7.16661498229372e-23 NA NA NA hsa-miR-429 KANK1 2.84108892259147 3.88520896426515e-64 -2.04494589285398 6.14282151736161e-68 MirTarget;miRanda;miRNATAP -0.227889877092644 5.29827127644096e-22 NA NA NA hsa-miR-200b-3p KANK2 2.11744072703209 1.66710572104191e-43 -1.03600021450898 6.97895190485011e-35 TargetScan -0.256075301106882 2.5573133116633e-48 NA NA NA hsa-miR-429 KANK2 2.84108892259147 3.88520896426515e-64 -1.03600021450898 6.97895190485011e-35 miRanda;miRNATAP -0.24416865068375 6.83463923848818e-56 NA NA NA hsa-miR-375 KANK4 2.09893673049766 1.68351780396203e-16 -1.43691823811847 9.56238754087143e-12 miRNATAP -0.163352631238334 5.16061387606773e-09 NA NA NA hsa-miR-429 KANK4 2.84108892259147 3.88520896426515e-64 -1.43691823811847 9.56238754087143e-12 miRNATAP -0.199013833639398 7.74771086024853e-07 NA NA NA hsa-miR-429 KAT2B 2.84108892259147 3.88520896426515e-64 -1.58713770510952 2.11994949717823e-57 miRanda -0.251781562894053 6.65645319679099e-39 NA NA NA hsa-miR-141-3p KATNAL1 2.99777540204168 1.26370498493024e-78 -1.08402942876846 2.5964427554243e-40 TargetScan -0.179120633203438 9.54814311548799e-29 NA NA NA hsa-miR-200b-3p KATNAL1 2.11744072703209 1.66710572104191e-43 -1.08402942876846 2.5964427554243e-40 TargetScan -0.166526030737014 6.59414644029876e-21 NA NA NA hsa-miR-429 KATNAL1 2.84108892259147 3.88520896426515e-64 -1.08402942876846 2.5964427554243e-40 miRNATAP -0.158120965375972 1.38364978364427e-23 NA NA NA hsa-miR-335-5p KAZALD1 -2.61355235628987 2.6462884165886e-51 0.565244761725227 0.00123070116667785 MirTarget -0.148096404567195 5.00060138082115e-06 NA NA NA hsa-miR-141-3p KBTBD11 2.99777540204168 1.26370498493024e-78 -1.27376692325044 2.87674128531081e-17 mirMAP -0.239819158071957 3.26597000236233e-16 NA NA NA hsa-miR-200a-3p KBTBD11 2.55218480823434 2.96135446816238e-51 -1.27376692325044 2.87674128531081e-17 mirMAP -0.17839015729355 8.42036884486725e-10 NA NA NA hsa-miR-21-3p KBTBD11 2.17476065946878 5.15299442583591e-75 -1.27376692325044 2.87674128531081e-17 mirMAP -0.276433490975652 4.85473977104943e-12 NA NA NA hsa-miR-429 KBTBD11 2.84108892259147 3.88520896426515e-64 -1.27376692325044 2.87674128531081e-17 MirTarget;miRanda -0.201060708563145 2.80829922835709e-12 NA NA NA hsa-miR-141-3p KBTBD12 2.99777540204168 1.26370498493024e-78 -2.56473508131234 3.31063468660652e-23 mirMAP -0.316006277653369 6.85294500975894e-10 NA NA NA hsa-miR-182-5p KBTBD12 2.36408084103818 2.60011457600281e-72 -2.56473508131234 3.31063468660652e-23 mirMAP -0.573620512132382 1.96320440982335e-20 NA NA NA hsa-miR-200a-3p KBTBD12 2.55218480823434 2.96135446816238e-51 -2.56473508131234 3.31063468660652e-23 mirMAP -0.202681504731449 6.14493330983586e-05 NA NA NA hsa-miR-378a-5p KBTBD4 -2.43173551693523 1.44932837789175e-68 0.000192847041804001 0.998118759345883 MirTarget -0.141396084937258 7.84551398072488e-15 NA NA NA hsa-miR-21-5p KBTBD6 2.32007501846389 3.08394781855554e-137 -0.650214766705834 1.42503592185711e-20 miRNAWalker2_validate;MirTarget -0.246852812805404 1.70175871699522e-30 NA NA NA hsa-miR-21-5p KBTBD7 2.32007501846389 3.08394781855554e-137 -0.62602489704352 4.75641087045912e-07 miRNAWalker2_validate -0.306212796610769 1.43100502382996e-15 NA NA NA hsa-miR-200b-3p KBTBD8 2.11744072703209 1.66710572104191e-43 -0.152883899138386 0.211626457945711 TargetScan -0.115034570561229 8.60173110524296e-06 NA NA NA hsa-miR-182-5p KCNA1 2.36408084103818 2.60011457600281e-72 -2.92558361314474 6.5800868813974e-30 miRNATAP -0.555823011032539 4.92247613955749e-19 NA NA NA hsa-miR-21-5p KCNA1 2.32007501846389 3.08394781855554e-137 -2.92558361314474 6.5800868813974e-30 miRNATAP -0.453580622436814 4.22573030564678e-08 NA NA NA hsa-miR-429 KCNA1 2.84108892259147 3.88520896426515e-64 -2.92558361314474 6.5800868813974e-30 miRanda;miRNATAP -0.535440677383669 8.39327398777351e-28 NA NA NA hsa-miR-96-5p KCNA1 3.24596558166606 1.92296159041707e-98 -2.92558361314474 6.5800868813974e-30 miRNATAP -0.650840030818798 4.520742100951e-38 NA NA NA hsa-miR-429 KCNA3 2.84108892259147 3.88520896426515e-64 -0.819233882801202 3.13254846564947e-05 miRanda -0.203426121722473 4.50353259434959e-08 NA NA NA hsa-miR-429 KCNA6 2.84108892259147 3.88520896426515e-64 -2.53204344734037 2.45522132193037e-38 miRanda -0.512410627911612 5.164402426124e-44 NA NA NA hsa-miR-375 KCNAB1 2.09893673049766 1.68351780396203e-16 -2.1357665207945 2.57168823677199e-67 miRNATAP -0.124515428042835 1.02306029854338e-12 NA NA NA hsa-miR-200b-3p KCNB1 2.11744072703209 1.66710572104191e-43 -4.37316589459594 1.02420393655674e-63 TargetScan -0.623588953822157 4.07261994602653e-27 NA NA NA hsa-miR-375 KCNB2 2.09893673049766 1.68351780396203e-16 -2.1690333507359 1.95717242383358e-20 miRanda -0.313361988769725 2.31732198979805e-24 NA NA NA hsa-miR-21-3p KCNC1 2.17476065946878 5.15299442583591e-75 -0.419819323532828 0.125779819998908 mirMAP -0.34482207760891 1.60531610843849e-06 NA NA NA hsa-miR-224-5p KCNC1 -2.22249420723892 1.07787949391113e-18 -0.419819323532828 0.125779819998908 mirMAP -0.256759383791525 1.01199623062787e-12 NA NA NA hsa-miR-183-5p KCND1 2.95681814393872 1.09965777344285e-92 -0.54563976197671 1.23924533300325e-08 mirMAP -0.125475294562084 4.95564676050057e-10 NA NA NA hsa-miR-429 KCND1 2.84108892259147 3.88520896426515e-64 -0.54563976197671 1.23924533300325e-08 miRNATAP -0.106032955163238 5.19940903928063e-09 NA NA NA hsa-miR-200b-3p KCND2 2.11744072703209 1.66710572104191e-43 -0.620305038541618 0.00162583660129406 MirTarget;TargetScan -0.204468253791779 9.12381189810751e-07 NA NA NA hsa-miR-200c-3p KCND2 2.07038651806183 6.84613386286599e-51 -0.620305038541618 0.00162583660129406 MirTarget;miRNATAP -0.284518993527328 4.37799375142295e-10 NA NA NA hsa-miR-429 KCND2 2.84108892259147 3.88520896426515e-64 -0.620305038541618 0.00162583660129406 MirTarget;PITA;miRanda;miRNATAP -0.217995363038457 4.10423307380176e-09 NA NA NA hsa-miR-200b-3p KCND3 2.11744072703209 1.66710572104191e-43 -1.6472717356446 2.67019410294081e-09 TargetScan -0.137441407522222 0.0205533017958406 NA NA NA hsa-miR-429 KCNE1 2.84108892259147 3.88520896426515e-64 -3.97972147276982 4.62769096356013e-57 miRNATAP -0.404378297959673 6.52403759821936e-16 NA NA NA hsa-miR-200a-5p KCNE3 2.58844508672328 1.79650654234569e-56 -0.512580357609526 9.16257418900335e-09 MirTarget -0.141845145966012 2.04335440195645e-16 NA NA NA hsa-miR-224-5p KCNE4 -2.22249420723892 1.07787949391113e-18 1.48860398073731 5.80051935115865e-10 mirMAP -0.302286449119529 8.53597694360533e-22 NA NA NA hsa-miR-139-5p KCNG3 -3.25846663863766 2.62018989415003e-112 1.83497396859328 2.97968100605333e-16 miRanda -0.324247203940039 3.22164994559368e-12 NA NA NA hsa-miR-224-5p KCNH1 -2.22249420723892 1.07787949391113e-18 1.67691955704213 2.06967598738521e-10 MirTarget -0.375868106199318 7.1188709842689e-28 NA NA NA hsa-miR-335-5p KCNH2 -2.61355235628987 2.6462884165886e-51 1.26394908945759 3.28615018943557e-07 miRNAWalker2_validate -0.189205115761348 4.19709217479648e-05 NA NA NA hsa-miR-429 KCNH8 2.84108892259147 3.88520896426515e-64 -3.08125415015192 8.97706620673628e-29 miRanda;miRNATAP -0.243201566158435 7.04857336449644e-06 NA NA NA hsa-miR-182-5p KCNIP1 2.36408084103818 2.60011457600281e-72 -2.04363050509809 1.47733128459893e-26 MirTarget -0.404700533310378 2.03391509318898e-18 NA NA NA hsa-miR-429 KCNIP1 2.84108892259147 3.88520896426515e-64 -2.04363050509809 1.47733128459893e-26 miRNATAP -0.253830160269417 7.46553376796724e-12 NA NA NA hsa-miR-182-5p KCNJ12 2.36408084103818 2.60011457600281e-72 -1.47809018982829 1.74332869418607e-16 mirMAP -0.313944308987975 2.84963033982135e-13 NA NA NA hsa-miR-96-5p KCNJ12 3.24596558166606 1.92296159041707e-98 -1.47809018982829 1.74332869418607e-16 mirMAP -0.324345344442469 4.58496392162408e-20 NA NA NA hsa-miR-200b-3p KCNJ15 2.11744072703209 1.66710572104191e-43 -0.303734766560402 0.0681241357503993 TargetScan -0.285598934224023 1.89308336458737e-16 NA NA NA hsa-miR-429 KCNJ15 2.84108892259147 3.88520896426515e-64 -0.303734766560402 0.0681241357503993 miRanda -0.198359177264996 2.1679212783854e-10 NA NA NA hsa-miR-429 KCNJ16 2.84108892259147 3.88520896426515e-64 -5.39298068658592 1.57838756504548e-65 miRanda -0.616125842792535 2.18948032169202e-22 NA NA NA hsa-miR-141-3p KCNJ2 2.99777540204168 1.26370498493024e-78 -1.76393304178556 8.52050444083173e-44 TargetScan;miRNATAP -0.289621474784258 1.18342323349976e-30 NA NA NA hsa-miR-182-5p KCNJ2 2.36408084103818 2.60011457600281e-72 -1.76393304178556 8.52050444083173e-44 miRNATAP -0.366741108097575 9.04882373922836e-33 NA NA NA hsa-miR-200a-3p KCNJ2 2.55218480823434 2.96135446816238e-51 -1.76393304178556 8.52050444083173e-44 miRNATAP -0.248617389593586 1.96792443208591e-23 NA NA NA hsa-miR-200c-3p KCNJ2 2.07038651806183 6.84613386286599e-51 -1.76393304178556 8.52050444083173e-44 miRNATAP -0.310077839567584 2.33391462638397e-24 NA NA NA hsa-miR-429 KCNJ2 2.84108892259147 3.88520896426515e-64 -1.76393304178556 8.52050444083173e-44 miRanda;miRNATAP -0.253995777230127 8.78905976798475e-25 NA NA NA hsa-miR-96-5p KCNJ2 3.24596558166606 1.92296159041707e-98 -1.76393304178556 8.52050444083173e-44 miRNATAP -0.321264308246048 1.08897016922826e-36 NA NA NA hsa-miR-200b-3p KCNJ5 2.11744072703209 1.66710572104191e-43 -0.50339272423311 0.000173297086610395 mirMAP -0.182101446053222 1.13536744007948e-10 NA NA NA hsa-miR-145-5p KCNK1 -2.62703571936687 7.64402900188551e-88 1.23868385128456 4.58194579660883e-07 MirTarget -0.186664813046343 0.00114733790742005 NA NA NA hsa-miR-183-5p KCNK2 2.95681814393872 1.09965777344285e-92 -1.68436592750629 1.76729460831538e-11 MirTarget;miRNATAP -0.405720075077914 1.31339185106165e-14 NA NA NA hsa-miR-200c-3p KCNK2 2.07038651806183 6.84613386286599e-51 -1.68436592750629 1.76729460831538e-11 miRNATAP -0.204359045556599 0.000544851110094652 NA NA NA hsa-miR-429 KCNK2 2.84108892259147 3.88520896426515e-64 -1.68436592750629 1.76729460831538e-11 PITA;miRanda;miRNATAP -0.165436469807996 0.000567084735975889 NA NA NA hsa-miR-141-3p KCNK3 2.99777540204168 1.26370498493024e-78 -1.87434649845534 1.0138987640139e-12 mirMAP -0.28555606522472 2.9430046089366e-08 NA NA NA hsa-miR-200a-3p KCNK3 2.55218480823434 2.96135446816238e-51 -1.87434649845534 1.0138987640139e-12 mirMAP -0.245699609070965 1.21912707003098e-06 NA NA NA hsa-miR-21-5p KCNK3 2.32007501846389 3.08394781855554e-137 -1.87434649845534 1.0138987640139e-12 mirMAP -0.61136642333281 8.80487917739721e-14 NA NA NA hsa-miR-335-5p KCNK5 -2.61355235628987 2.6462884165886e-51 -0.0183380748598028 0.929922368890708 miRNAWalker2_validate -0.112150054382526 0.00376127542150367 NA NA NA hsa-miR-486-5p KCNK6 -3.87258704301474 1.22658629378451e-80 1.29506663214078 1.20540250468269e-23 miRanda -0.118711713030057 3.09932069654515e-09 NA NA NA hsa-miR-183-5p KCNMA1 2.95681814393872 1.09965777344285e-92 -1.07397054162244 2.65699507311913e-09 miRNATAP -0.182518018329152 1.80309072931911e-06 NA NA NA hsa-miR-21-3p KCNMA1 2.17476065946878 5.15299442583591e-75 -1.07397054162244 2.65699507311913e-09 MirTarget -0.264668582144858 2.76776642559313e-08 NA NA NA hsa-miR-429 KCNMA1 2.84108892259147 3.88520896426515e-64 -1.07397054162244 2.65699507311913e-09 miRanda;miRNATAP -0.218698443592511 1.56427018500547e-10 NA NA NA hsa-miR-429 KCNMB1 2.84108892259147 3.88520896426515e-64 -2.49496294869867 7.14612193436087e-52 miRanda -0.252463721525027 1.38191941614906e-14 NA NA NA hsa-miR-429 KCNMB4 2.84108892259147 3.88520896426515e-64 -0.25999025227551 0.0363525911503053 miRanda -0.13638793417669 5.19996613049208e-09 NA NA NA hsa-miR-429 KCNN3 2.84108892259147 3.88520896426515e-64 -0.366705000888428 0.00875142824130492 miRNATAP -0.150645060558869 1.05424394609296e-08 NA NA NA hsa-miR-96-5p KCNN3 3.24596558166606 1.92296159041707e-98 -0.366705000888428 0.00875142824130492 TargetScan -0.15204965838077 3.21802557463421e-08 NA NA NA hsa-miR-375 KCNN4 2.09893673049766 1.68351780396203e-16 -0.365676975445489 0.0682849616850012 miRNAWalker2_validate -0.209658633812904 7.80110120577112e-16 NA NA NA hsa-miR-200b-3p KCNQ4 2.11744072703209 1.66710572104191e-43 -2.00601887339821 2.87129859849754e-16 TargetScan -0.141955010731346 0.00743752036550139 NA NA NA hsa-miR-200c-3p KCNQ4 2.07038651806183 6.84613386286599e-51 -2.00601887339821 2.87129859849754e-16 miRNATAP -0.190328987151245 0.0010873660280215 NA NA NA hsa-miR-429 KCNQ4 2.84108892259147 3.88520896426515e-64 -2.00601887339821 2.87129859849754e-16 miRanda;miRNATAP -0.119474070231824 0.011665283607021 NA NA NA hsa-miR-139-5p KCNQ5 -3.25846663863766 2.62018989415003e-112 0.709814228917516 0.00238843131795685 miRanda -0.2363164060536 8.42103967508205e-07 NA NA NA hsa-miR-141-3p KCNS1 2.99777540204168 1.26370498493024e-78 -2.5665698830388 6.59105430153009e-22 MirTarget -0.203893593164262 0.000124821160923031 NA NA NA hsa-miR-200a-3p KCNS1 2.55218480823434 2.96135446816238e-51 -2.5665698830388 6.59105430153009e-22 MirTarget -0.169241275502829 0.00118792811199734 NA NA NA hsa-miR-429 KCNS1 2.84108892259147 3.88520896426515e-64 -2.5665698830388 6.59105430153009e-22 miRNATAP -0.144890313401281 0.00523614306501131 NA NA NA hsa-miR-375 KCNT2 2.09893673049766 1.68351780396203e-16 -1.81626506694586 1.16864555753689e-28 mirMAP -0.180111926059199 2.31838382280807e-16 NA NA NA hsa-miR-141-3p KCTD12 2.99777540204168 1.26370498493024e-78 -1.79741890724673 5.41613909344923e-64 TargetScan -0.386399966248061 4.29274054998861e-81 NA NA NA hsa-miR-21-5p KCTD12 2.32007501846389 3.08394781855554e-137 -1.79741890724673 5.41613909344923e-64 mirMAP -0.386445789820893 1.03451712626426e-28 NA NA NA hsa-miR-429 KCTD12 2.84108892259147 3.88520896426515e-64 -1.79741890724673 5.41613909344923e-64 miRanda;miRNATAP -0.314070528776825 3.45296302345495e-53 NA NA NA hsa-miR-10b-5p KCTD17 -2.10996264627796 7.36811595736367e-72 0.862121339894749 3.47101971963236e-18 MirTarget;miRNATAP -0.206923233059354 6.66285297729174e-15 NA NA NA hsa-miR-335-5p KCTD17 -2.61355235628987 2.6462884165886e-51 0.862121339894749 3.47101971963236e-18 miRNAWalker2_validate -0.145833876920109 3.27985115057731e-15 NA NA NA hsa-miR-141-3p KCTD20 2.99777540204168 1.26370498493024e-78 -0.522937645404041 1.61102511851964e-09 MirTarget;TargetScan -0.129086405249865 1.26544996794066e-14 NA NA NA hsa-miR-200a-3p KCTD20 2.55218480823434 2.96135446816238e-51 -0.522937645404041 1.61102511851964e-09 MirTarget -0.136624229999009 7.34524934292875e-17 NA NA NA hsa-miR-429 KCTD20 2.84108892259147 3.88520896426515e-64 -0.522937645404041 1.61102511851964e-09 miRNATAP -0.117278254452652 7.43603052552249e-13 NA NA NA hsa-miR-139-5p KDELC1 -3.25846663863766 2.62018989415003e-112 0.366480476505469 2.94820022889719e-05 miRanda -0.102621401068104 1.16539392277623e-08 NA NA NA hsa-miR-200b-3p KDELC1 2.11744072703209 1.66710572104191e-43 0.366480476505469 2.94820022889719e-05 TargetScan -0.106018057883402 1.06495649855796e-08 NA NA NA hsa-miR-182-5p KDELC2 2.36408084103818 2.60011457600281e-72 -0.723740062256294 1.39294527324776e-16 MirTarget -0.164503954944556 3.67803282998376e-15 NA NA NA hsa-miR-183-5p KDELC2 2.95681814393872 1.09965777344285e-92 -0.723740062256294 1.39294527324776e-16 miRNAWalker2_validate -0.131081813160386 1.64441688354372e-12 NA NA NA hsa-miR-139-5p KDM5B -3.25846663863766 2.62018989415003e-112 0.898277469607375 6.52498705964915e-31 miRanda -0.194617859720112 2.42853056144579e-34 NA NA NA hsa-miR-486-5p KDM5B -3.87258704301474 1.22658629378451e-80 0.898277469607375 6.52498705964915e-31 miRanda -0.139842429747409 1.70570578662613e-32 NA NA NA hsa-miR-200b-3p KDR 2.11744072703209 1.66710572104191e-43 -1.26178488366313 1.81783097872036e-35 miRNAWalker2_validate;miRTarBase;TargetScan -0.262999260406618 3.87053169124588e-34 NA NA NA hsa-miR-200c-3p KDR 2.07038651806183 6.84613386286599e-51 -1.26178488366313 1.81783097872036e-35 miRNATAP -0.289279648433676 3.71227459751374e-34 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-429 KDR 2.84108892259147 3.88520896426515e-64 -1.26178488366313 1.81783097872036e-35 PITA;miRanda;miRNATAP -0.244793933063007 3.13570384816226e-37 NA NA NA hsa-miR-429 KERA 2.84108892259147 3.88520896426515e-64 -0.548667782905623 0.0235212178914974 miRanda -0.333648634071128 1.77591666324099e-13 NA NA NA hsa-miR-141-3p KHDRBS3 2.99777540204168 1.26370498493024e-78 -0.535630864859294 7.93502963529463e-05 TargetScan -0.114811590775896 1.35984636024326e-05 NA NA NA hsa-miR-375 KHDRBS3 2.09893673049766 1.68351780396203e-16 -0.535630864859294 7.93502963529463e-05 miRanda -0.163350499452152 1.33964757425306e-20 NA NA NA hsa-miR-224-5p KIAA0040 -2.22249420723892 1.07787949391113e-18 0.367039522069309 0.00180529927334225 mirMAP -0.159997278581442 6.80018791260307e-26 NA NA NA hsa-miR-139-5p KIAA0319 -3.25846663863766 2.62018989415003e-112 0.846377059411825 0.00158654416727078 miRanda -0.220871320091171 6.22826317435411e-05 NA NA NA hsa-miR-183-5p KIAA0355 2.95681814393872 1.09965777344285e-92 -0.839888715749088 9.49359998690135e-39 MirTarget;miRNATAP -0.144882259896991 1.05118521513266e-25 NA NA NA hsa-miR-200a-5p KIAA0355 2.58844508672328 1.79650654234569e-56 -0.839888715749088 9.49359998690135e-39 MirTarget -0.119242027114663 2.39985314637906e-20 NA NA NA hsa-miR-200b-3p KIAA0355 2.11744072703209 1.66710572104191e-43 -0.839888715749088 9.49359998690135e-39 MirTarget;TargetScan -0.135205848762749 3.9596829960545e-22 NA NA NA hsa-miR-200c-3p KIAA0355 2.07038651806183 6.84613386286599e-51 -0.839888715749088 9.49359998690135e-39 MirTarget;miRNATAP -0.182248207560121 2.38493415764389e-33 NA NA NA hsa-miR-21-5p KIAA0355 2.32007501846389 3.08394781855554e-137 -0.839888715749088 9.49359998690135e-39 MirTarget -0.215524473702999 5.29413237063212e-26 NA NA NA hsa-miR-429 KIAA0355 2.84108892259147 3.88520896426515e-64 -0.839888715749088 9.49359998690135e-39 MirTarget;PITA;miRanda;miRNATAP -0.141031375122701 3.34977203235262e-30 NA NA NA hsa-miR-141-3p KIAA0408 2.99777540204168 1.26370498493024e-78 -6.77635661274003 2.35177949256626e-67 MirTarget;TargetScan -1.11313326407261 5.83832643432176e-46 NA NA NA hsa-miR-141-5p KIAA0408 2.38411349683216 4.56310582620282e-58 -6.77635661274003 2.35177949256626e-67 MirTarget -1.09415296118369 8.00079510247973e-36 NA NA NA hsa-miR-200a-3p KIAA0408 2.55218480823434 2.96135446816238e-51 -6.77635661274003 2.35177949256626e-67 MirTarget -0.900567775449332 1.28785235564081e-30 NA NA NA hsa-miR-21-3p KIAA0430 2.17476065946878 5.15299442583591e-75 -0.549152274386429 1.79551002674717e-21 MirTarget -0.149613661539952 5.0381524552263e-23 NA NA NA hsa-miR-429 KIAA1210 2.84108892259147 3.88520896426515e-64 -0.746964624841095 0.00136637318101393 miRNATAP -0.154091315097993 0.000495777495344816 NA NA NA hsa-miR-486-5p KIAA1257 -3.87258704301474 1.22658629378451e-80 1.55861265620229 3.04949033259401e-16 miRanda -0.186265360885677 1.90364453425481e-10 NA NA NA hsa-miR-429 KIAA1324L 2.84108892259147 3.88520896426515e-64 -0.8185816781398 2.64659076673264e-07 miRNATAP -0.143154189085793 2.14102722330924e-06 NA NA NA hsa-miR-452-5p KIAA1324L -2.48486455572568 1.24430987974325e-33 -0.8185816781398 2.64659076673264e-07 MirTarget -0.112506372494853 1.02906108747922e-05 NA NA NA hsa-miR-200b-3p KIAA1462 2.11744072703209 1.66710572104191e-43 -0.894733095554471 4.07536183567301e-18 MirTarget;TargetScan -0.299581326367512 1.05038038536135e-45 NA NA NA hsa-miR-200c-3p KIAA1462 2.07038651806183 6.84613386286599e-51 -0.894733095554471 4.07536183567301e-18 MirTarget -0.360336870412728 1.02794865002582e-55 NA NA NA hsa-miR-21-3p KIAA1462 2.17476065946878 5.15299442583591e-75 -0.894733095554471 4.07536183567301e-18 MirTarget -0.109566129865579 7.40720279665842e-05 NA NA NA hsa-miR-429 KIAA1462 2.84108892259147 3.88520896426515e-64 -0.894733095554471 4.07536183567301e-18 MirTarget;PITA;miRanda;miRNATAP -0.252068325960383 3.21223831630342e-40 NA NA NA hsa-miR-335-5p KIAA1522 -2.61355235628987 2.6462884165886e-51 0.92558832102584 2.24993794534402e-27 miRNAWalker2_validate -0.115977233166842 7.59607130989632e-13 NA NA NA hsa-miR-139-5p KIAA1524 -3.25846663863766 2.62018989415003e-112 1.55350703321716 1.90657460595278e-30 miRanda -0.342599119212726 5.23390530102049e-35 NA NA NA hsa-miR-10b-5p KIAA1549 -2.10996264627796 7.36811595736367e-72 0.489841308650103 1.61404217724123e-06 miRNATAP -0.154494385481876 1.28992585031354e-08 NA NA NA hsa-miR-182-5p KIAA1614 2.36408084103818 2.60011457600281e-72 -1.55287301616356 3.51662725560383e-38 mirMAP -0.427711972814329 4.09776899345496e-52 NA NA NA hsa-miR-183-5p KIAA1614 2.95681814393872 1.09965777344285e-92 -1.55287301616356 3.51662725560383e-38 mirMAP -0.3999969510772 4.42882292814328e-59 NA NA NA hsa-miR-96-5p KIAA1614 3.24596558166606 1.92296159041707e-98 -1.55287301616356 3.51662725560383e-38 mirMAP -0.368443588358965 1.12736274305794e-56 NA NA NA hsa-miR-139-5p KIAA1644 -3.25846663863766 2.62018989415003e-112 1.06971961713243 5.04812834911815e-08 mirMAP -0.183477175576477 6.15579777059903e-06 NA NA NA hsa-miR-141-3p KIAA1644 2.99777540204168 1.26370498493024e-78 1.06971961713243 5.04812834911815e-08 mirMAP -0.131056028002902 0.000647223239205563 NA NA NA hsa-miR-200a-3p KIAA1644 2.55218480823434 2.96135446816238e-51 1.06971961713243 5.04812834911815e-08 mirMAP -0.126703776769301 0.000776790179926012 NA NA NA hsa-miR-335-5p KIAA1644 -2.61355235628987 2.6462884165886e-51 1.06971961713243 5.04812834911815e-08 miRNAWalker2_validate;mirMAP -0.132862287111614 0.000294696608414271 NA NA NA hsa-miR-21-5p KIAA1671 2.32007501846389 3.08394781855554e-137 -0.875430488955304 2.18311427791016e-23 mirMAP -0.279928168579039 1.40901383280317e-24 NA NA NA hsa-miR-452-5p KIAA1958 -2.48486455572568 1.24430987974325e-33 -0.188340304194604 0.179658152453416 mirMAP -0.113860381258086 3.29878270308853e-07 NA NA NA hsa-miR-141-3p KIDINS220 2.99777540204168 1.26370498493024e-78 -0.670641230766213 1.2866423600809e-18 MirTarget -0.10605737052898 1.17837005909692e-12 NA NA NA hsa-miR-183-5p KIF13A 2.95681814393872 1.09965777344285e-92 -1.04466955177769 2.78344291551554e-23 miRNATAP -0.139939378099256 5.55809014934197e-10 NA NA NA hsa-miR-200b-3p KIF13A 2.11744072703209 1.66710572104191e-43 -1.04466955177769 2.78344291551554e-23 TargetScan -0.153427787254806 1.2798883776369e-11 NA NA NA hsa-miR-200c-3p KIF13A 2.07038651806183 6.84613386286599e-51 -1.04466955177769 2.78344291551554e-23 miRNATAP -0.161862432993178 8.65708015869743e-11 NA NA NA hsa-miR-429 KIF13A 2.84108892259147 3.88520896426515e-64 -1.04466955177769 2.78344291551554e-23 PITA;miRanda;miRNATAP -0.176638208683506 1.2400483201846e-18 NA NA NA hsa-miR-139-5p KIF15 -3.25846663863766 2.62018989415003e-112 2.7820844261945 7.48226780202604e-64 miRanda -0.554249278287094 4.72042649626188e-59 NA NA NA hsa-miR-486-5p KIF15 -3.87258704301474 1.22658629378451e-80 2.7820844261945 7.48226780202604e-64 miRanda -0.268568955867153 2.77926113552626e-24 NA NA NA hsa-miR-141-3p KIF17 2.99777540204168 1.26370498493024e-78 -1.17633998273391 1.64922956013024e-24 MirTarget;TargetScan -0.278930798555516 1.08395669606161e-36 NA NA NA hsa-miR-200a-3p KIF17 2.55218480823434 2.96135446816238e-51 -1.17633998273391 1.64922956013024e-24 MirTarget -0.190472945042861 8.74801717127724e-18 NA NA NA hsa-miR-429 KIF17 2.84108892259147 3.88520896426515e-64 -1.17633998273391 1.64922956013024e-24 miRNATAP -0.213139755291911 2.0990448071263e-22 NA NA NA hsa-miR-139-5p KIF18A -3.25846663863766 2.62018989415003e-112 2.38902083199541 2.58272266932097e-53 miRanda -0.520351179345068 2.25265414785046e-60 NA NA NA hsa-miR-182-5p KIF19 2.36408084103818 2.60011457600281e-72 -1.45694561632296 2.0362616820919e-09 miRNATAP -0.424028385581023 2.00099509190069e-13 NA NA NA hsa-miR-96-5p KIF19 3.24596558166606 1.92296159041707e-98 -1.45694561632296 2.0362616820919e-09 TargetScan;miRNATAP -0.382532920705141 1.11104891826218e-15 NA NA NA hsa-miR-10b-5p KIF1A -2.10996264627796 7.36811595736367e-72 1.63572220018164 6.78074194083463e-05 mirMAP -0.742190440038737 8.35550481275607e-12 NA NA NA hsa-miR-182-5p KIF1B 2.36408084103818 2.60011457600281e-72 -0.766642753394271 7.34519794927333e-21 mirMAP -0.113716483630385 9.61844104448818e-09 NA NA NA hsa-miR-141-3p KIF1C 2.99777540204168 1.26370498493024e-78 -0.530841519866912 2.45227404770519e-10 TargetScan;miRNATAP -0.132112310756655 3.22777417111317e-16 NA NA NA hsa-miR-141-5p KIF1C 2.38411349683216 4.56310582620282e-58 -0.530841519866912 2.45227404770519e-10 mirMAP -0.177311294175702 1.30327407458706e-23 NA NA NA hsa-miR-10b-5p KIF21A -2.10996264627796 7.36811595736367e-72 0.555528333264837 1.30981034336941e-06 miRNAWalker2_validate -0.162676388739491 1.04750827088632e-07 NA NA NA hsa-miR-145-5p KIF21A -2.62703571936687 7.64402900188551e-88 0.555528333264837 1.30981034336941e-06 MirTarget -0.103858933309768 0.000104432263131849 NA NA NA hsa-miR-139-5p KIF23 -3.25846663863766 2.62018989415003e-112 2.64309000375393 1.31278695254902e-74 miRanda -0.518307044113435 2.42783492025022e-66 NA NA NA hsa-miR-96-5p KIF26A 3.24596558166606 1.92296159041707e-98 -1.49247644253838 6.32140659226036e-23 TargetScan -0.311048083058781 2.2048952348655e-25 NA NA NA hsa-miR-224-5p KIF26B -2.22249420723892 1.07787949391113e-18 3.09539388973959 5.92082129636975e-70 mirMAP -0.139706419316572 3.24956705344724e-08 NA NA NA hsa-miR-452-5p KIF26B -2.48486455572568 1.24430987974325e-33 3.09539388973959 5.92082129636975e-70 mirMAP -0.221237239580107 2.22458134943907e-13 NA NA NA hsa-miR-378a-5p KIF3B -2.43173551693523 1.44932837789175e-68 0.283544990227211 2.21110051429036e-05 miRNATAP -0.144525963039655 1.44245318154619e-22 NA NA NA hsa-miR-210-3p KIF5A 2.38367203491819 3.73261999106754e-22 -1.48742925524505 5.42405536046895e-08 MirTarget -0.146144301355107 8.73634588532534e-05 NA NA NA hsa-miR-96-5p KIF5A 3.24596558166606 1.92296159041707e-98 -1.48742925524505 5.42405536046895e-08 TargetScan -0.233707772098952 1.71443311409698e-05 NA NA NA hsa-miR-21-3p KIF5C 2.17476065946878 5.15299442583591e-75 0.0690079439146918 0.73489630121368 mirMAP -0.175921250917701 0.0010226455424303 NA NA NA hsa-miR-452-5p KIF6 -2.48486455572568 1.24430987974325e-33 0.227455788364192 0.187539518029997 mirMAP -0.128899948418844 2.67529669880625e-06 NA NA NA hsa-miR-335-5p KIFC2 -2.61355235628987 2.6462884165886e-51 1.93168992800946 1.1083716501869e-41 miRNAWalker2_validate -0.208742875624015 3.51957538732162e-14 NA NA NA hsa-miR-21-3p KIRREL3 2.17476065946878 5.15299442583591e-75 -1.22791092947754 4.14790893682007e-07 MirTarget -0.306550130273527 1.67823438041718e-06 NA NA NA hsa-miR-429 KIT 2.84108892259147 3.88520896426515e-64 -3.55980779277124 2.17700605158782e-58 miRNATAP -0.336829033851034 3.36923704405637e-14 NA NA NA hsa-miR-429 KL 2.84108892259147 3.88520896426515e-64 -3.08660991898312 4.30689619617065e-79 miRanda -0.484156905610755 5.17092109522278e-51 NA NA NA hsa-miR-10b-5p KLC2 -2.10996264627796 7.36811595736367e-72 1.1468056186047 2.10983792785086e-40 miRNATAP -0.313682850272634 1.12817073797054e-42 NA NA NA hsa-miR-139-5p KLC2 -3.25846663863766 2.62018989415003e-112 1.1468056186047 2.10983792785086e-40 miRanda;miRNATAP -0.186870411543762 5.93827864161635e-25 NA NA NA hsa-miR-200b-3p KLF10 2.11744072703209 1.66710572104191e-43 -1.2822855310566 4.0104075488289e-48 TargetScan -0.189252911541944 1.08405832707164e-22 NA NA NA hsa-miR-200c-3p KLF10 2.07038651806183 6.84613386286599e-51 -1.2822855310566 4.0104075488289e-48 miRNATAP -0.230832467793711 6.69153156560086e-28 NA NA NA hsa-miR-429 KLF10 2.84108892259147 3.88520896426515e-64 -1.2822855310566 4.0104075488289e-48 PITA;miRanda;miRNATAP -0.18860375411821 2.99612820740907e-28 NA NA NA hsa-miR-141-3p KLF11 2.99777540204168 1.26370498493024e-78 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate;MirTarget -0.18130465417437 2.09390327369665e-28 NA NA NA hsa-miR-182-5p KLF11 2.36408084103818 2.60011457600281e-72 -1.36252050722545 2.98418037545873e-64 MirTarget -0.228303888057597 5.30328400552381e-30 NA NA NA hsa-miR-200a-3p KLF11 2.55218480823434 2.96135446816238e-51 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate;MirTarget -0.172554627390354 1.02405720032334e-26 NA NA NA hsa-miR-200b-3p KLF11 2.11744072703209 1.66710572104191e-43 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate -0.18136928772325 7.25506007385319e-24 NA NA NA hsa-miR-200c-3p KLF11 2.07038651806183 6.84613386286599e-51 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate -0.189720595439794 1.24875216845081e-21 NA NA NA hsa-miR-429 KLF11 2.84108892259147 3.88520896426515e-64 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate;miRNATAP -0.169803882373107 3.1684459878567e-26 NA NA NA hsa-miR-141-3p KLF12 2.99777540204168 1.26370498493024e-78 -0.576392780554785 7.57826311599842e-09 MirTarget;TargetScan -0.138931546631831 6.15163752260048e-13 NA NA NA hsa-miR-200a-3p KLF12 2.55218480823434 2.96135446816238e-51 -0.576392780554785 7.57826311599842e-09 MirTarget -0.129448001103677 8.82064318817135e-12 NA NA NA hsa-miR-200b-3p KLF12 2.11744072703209 1.66710572104191e-43 -0.576392780554785 7.57826311599842e-09 TargetScan -0.125641595834132 2.92564413860313e-09 NA NA NA hsa-miR-21-5p KLF12 2.32007501846389 3.08394781855554e-137 -0.576392780554785 7.57826311599842e-09 mirMAP -0.108546469190554 0.000528302338249221 NA NA NA hsa-miR-429 KLF12 2.84108892259147 3.88520896426515e-64 -0.576392780554785 7.57826311599842e-09 PITA;miRNATAP -0.125142323107672 3.18120998187109e-11 NA NA NA hsa-miR-141-5p KLF13 2.38411349683216 4.56310582620282e-58 -0.896526705579424 4.61689653388107e-25 mirMAP -0.140126319115833 1.27595454230502e-13 NA NA NA hsa-miR-182-5p KLF13 2.36408084103818 2.60011457600281e-72 -0.896526705579424 4.61689653388107e-25 MirTarget;miRNATAP -0.19190881894312 2.80217002650473e-20 NA NA NA hsa-miR-200b-3p KLF13 2.11744072703209 1.66710572104191e-43 -0.896526705579424 4.61689653388107e-25 TargetScan -0.151619015169813 3.83036641768317e-16 NA NA NA hsa-miR-200c-3p KLF13 2.07038651806183 6.84613386286599e-51 -0.896526705579424 4.61689653388107e-25 miRNATAP -0.189663866602219 1.16555499886551e-20 NA NA NA hsa-miR-21-3p KLF13 2.17476065946878 5.15299442583591e-75 -0.896526705579424 4.61689653388107e-25 mirMAP -0.137204751225768 4.02384777020153e-09 NA NA NA hsa-miR-429 KLF13 2.84108892259147 3.88520896426515e-64 -0.896526705579424 4.61689653388107e-25 miRNATAP -0.15990573264887 3.12706961888011e-22 NA NA NA hsa-miR-96-5p KLF13 3.24596558166606 1.92296159041707e-98 -0.896526705579424 4.61689653388107e-25 TargetScan;miRNATAP -0.175117537833805 1.92836753206665e-24 NA NA NA hsa-miR-182-5p KLF15 2.36408084103818 2.60011457600281e-72 -3.54603201609238 4.11340435184008e-64 MirTarget;miRNATAP -0.60565078731515 4.58815408545867e-31 NA NA NA hsa-miR-335-5p KLF16 -2.61355235628987 2.6462884165886e-51 1.23552750076511 5.40232482761962e-34 mirMAP -0.201738902554945 4.38731623181513e-26 NA NA NA hsa-miR-141-3p KLF3 2.99777540204168 1.26370498493024e-78 -0.554330026163965 2.9251145288686e-18 TargetScan;miRNATAP -0.100101247685112 6.71674927617038e-16 NA NA NA hsa-miR-200b-3p KLF3 2.11744072703209 1.66710572104191e-43 -0.554330026163965 2.9251145288686e-18 TargetScan -0.107765949016648 1.67792671471536e-15 NA NA NA hsa-miR-21-5p KLF3 2.32007501846389 3.08394781855554e-137 -0.554330026163965 2.9251145288686e-18 miRNATAP -0.193891681199854 7.1580165334174e-23 NA NA NA hsa-miR-200b-3p KLF4 2.11744072703209 1.66710572104191e-43 -2.5658507723861 1.98241408884064e-67 MirTarget;TargetScan -0.318241517505975 1.36421966013675e-21 NA NA NA hsa-miR-200c-3p KLF4 2.07038651806183 6.84613386286599e-51 -2.5658507723861 1.98241408884064e-67 MirTarget;miRNATAP -0.480814879410328 2.74192522750191e-41 NA NA NA hsa-miR-375 KLF4 2.09893673049766 1.68351780396203e-16 -2.5658507723861 1.98241408884064e-67 miRanda;miRNATAP -0.107900770782367 3.2799038965094e-07 26224477 MiR 375 targets KLF4 and impacts the proliferation of colorectal carcinoma; Subsequently using the luciferase reporter assays we found that the KLF4 untranslated region 3'UTR carries the direct binding site of miR-375; Inhibition of KLF4 performed similar effects with miR-375 overexpression on CRC cells and overexpression of KLF4 could significantly reverse the tumor suppressive effects of miR-375 on CRC cells; Furthermore we found overexpressed miR-375 effectively repressed tumor growth via KLF4 in xenograft animal experiment; Taken together these results illustrated that miR-375 depresses proliferation of CRC through regulating 3'UTR of KLF4 mRNA which might be a promising therapeutic target for treating colorectal cancers colorectal cancer hsa-miR-429 KLF4 2.84108892259147 3.88520896426515e-64 -2.5658507723861 1.98241408884064e-67 MirTarget;PITA;miRanda;miRNATAP -0.349728467927596 9.21186465368341e-33 NA NA NA hsa-miR-182-5p KLF5 2.36408084103818 2.60011457600281e-72 -1.34460254713941 3.1182032908979e-12 miRNATAP -0.293122353914159 2.10626624232176e-10 NA NA NA hsa-miR-21-5p KLF5 2.32007501846389 3.08394781855554e-137 -1.34460254713941 3.1182032908979e-12 miRNAWalker2_validate -0.161191810211141 0.00817362097300997 NA NA NA hsa-miR-375 KLF5 2.09893673049766 1.68351780396203e-16 -1.34460254713941 3.1182032908979e-12 miRNATAP -0.25484462449954 2.84626671922698e-24 NA NA NA hsa-miR-96-5p KLF5 3.24596558166606 1.92296159041707e-98 -1.34460254713941 3.1182032908979e-12 miRNATAP -0.208336210131635 5.80144921651517e-08 NA NA NA hsa-miR-141-3p KLF6 2.99777540204168 1.26370498493024e-78 -1.37238104447323 3.37677087181227e-49 TargetScan;miRNATAP -0.237924982832484 2.13952760808872e-38 NA NA NA hsa-miR-200a-3p KLF6 2.55218480823434 2.96135446816238e-51 -1.37238104447323 3.37677087181227e-49 miRNATAP -0.18060201182069 9.18714885970041e-23 NA NA NA hsa-miR-200a-5p KLF6 2.58844508672328 1.79650654234569e-56 -1.37238104447323 3.37677087181227e-49 miRNATAP -0.171367261231986 1.28343631980084e-19 NA NA NA hsa-miR-200b-3p KLF6 2.11744072703209 1.66710572104191e-43 -1.37238104447323 3.37677087181227e-49 TargetScan -0.186959282760515 8.66769270253547e-20 NA NA NA hsa-miR-21-5p KLF6 2.32007501846389 3.08394781855554e-137 -1.37238104447323 3.37677087181227e-49 miRNATAP -0.265706125768795 1.48123532644609e-18 NA NA NA hsa-miR-429 KLF6 2.84108892259147 3.88520896426515e-64 -1.37238104447323 3.37677087181227e-49 miRanda -0.186326122112001 1.52658252439928e-24 NA NA NA hsa-miR-182-5p KLF7 2.36408084103818 2.60011457600281e-72 -0.960860641075609 9.39965862664561e-13 MirTarget;miRNATAP -0.192244877899763 2.52880060638518e-09 NA NA NA hsa-miR-200a-5p KLF7 2.58844508672328 1.79650654234569e-56 -0.960860641075609 9.39965862664561e-13 miRNATAP -0.135261395885702 3.36473393143296e-07 NA NA NA hsa-miR-21-5p KLF7 2.32007501846389 3.08394781855554e-137 -0.960860641075609 9.39965862664561e-13 mirMAP -0.155847023803318 0.000243045740496368 NA NA NA hsa-miR-429 KLF7 2.84108892259147 3.88520896426515e-64 -0.960860641075609 9.39965862664561e-13 miRNATAP -0.204863026815084 7.72060009970379e-16 NA NA NA hsa-miR-429 KLF8 2.84108892259147 3.88520896426515e-64 -1.47188476442057 5.81400441959106e-30 miRanda -0.180884932108471 5.80078039042562e-13 NA NA NA hsa-miR-200a-5p KLF9 2.58844508672328 1.79650654234569e-56 -1.7429680316518 2.98275437403582e-61 MirTarget;miRNATAP -0.284979340525323 2.70295707673675e-41 NA NA NA hsa-miR-200b-3p KLF9 2.11744072703209 1.66710572104191e-43 -1.7429680316518 2.98275437403582e-61 TargetScan -0.288389907976558 1.45294640545342e-35 NA NA NA hsa-miR-200c-3p KLF9 2.07038651806183 6.84613386286599e-51 -1.7429680316518 2.98275437403582e-61 miRNAWalker2_validate;miRTarBase;miRNATAP -0.370308003675866 1.40559263229779e-49 NA NA NA hsa-miR-21-5p KLF9 2.32007501846389 3.08394781855554e-137 -1.7429680316518 2.98275437403582e-61 miRNAWalker2_validate -0.411775824457141 1.68311522946659e-33 NA NA NA hsa-miR-429 KLF9 2.84108892259147 3.88520896426515e-64 -1.7429680316518 2.98275437403582e-61 PITA;miRanda;miRNATAP -0.293833665410002 3.97323615052055e-47 NA NA NA hsa-miR-200b-3p KLHDC1 2.11744072703209 1.66710572104191e-43 -1.46137956613172 3.5740269082987e-32 MirTarget -0.136360362470307 5.20917344564022e-07 NA NA NA hsa-miR-200c-3p KLHDC1 2.07038651806183 6.84613386286599e-51 -1.46137956613172 3.5740269082987e-32 MirTarget -0.248383408918845 3.59899398143029e-17 NA NA NA hsa-miR-429 KLHDC1 2.84108892259147 3.88520896426515e-64 -1.46137956613172 3.5740269082987e-32 miRanda -0.199567731194288 7.92317506325611e-17 NA NA NA hsa-miR-224-5p KLHDC7A -2.22249420723892 1.07787949391113e-18 -1.06498995352819 0.00478463991605761 mirMAP -0.397808497383201 8.83498153367304e-16 NA NA NA hsa-miR-335-5p KLHDC7B -2.61355235628987 2.6462884165886e-51 1.48979577336376 2.51390889708617e-10 miRNAWalker2_validate -0.233443343453711 1.10509406896061e-07 NA NA NA hsa-miR-486-5p KLHL1 -3.87258704301474 1.22658629378451e-80 0.796017516251436 0.0108986476370087 miRanda -0.15294723080285 0.00129112872544051 NA NA NA hsa-miR-429 KLHL13 2.84108892259147 3.88520896426515e-64 -3.1871504639887 4.77445821811942e-53 miRanda -0.38705209689607 4.90316047879507e-21 NA NA NA hsa-miR-200b-3p KLHL14 2.11744072703209 1.66710572104191e-43 -1.45187804996542 1.55252493201745e-11 TargetScan -0.266076405561841 6.78861893954895e-09 NA NA NA hsa-miR-429 KLHL14 2.84108892259147 3.88520896426515e-64 -1.45187804996542 1.55252493201745e-11 PITA;miRanda;miRNATAP -0.302177936322927 1.1894620274379e-13 NA NA NA hsa-miR-21-5p KLHL15 2.32007501846389 3.08394781855554e-137 -0.687175756471496 7.41218597999873e-17 miRNAWalker2_validate;miRNATAP -0.334352113385367 3.56752848153276e-41 NA NA NA hsa-miR-335-5p KLHL17 -2.61355235628987 2.6462884165886e-51 1.16090038848978 5.79495737750803e-27 miRNAWalker2_validate -0.158055917826642 9.4665423019289e-15 NA NA NA hsa-miR-182-5p KLHL2 2.36408084103818 2.60011457600281e-72 -0.875859110167897 2.95482349701954e-22 miRNATAP -0.145670916514369 2.54827187348007e-11 NA NA NA hsa-miR-96-5p KLHL2 3.24596558166606 1.92296159041707e-98 -0.875859110167897 2.95482349701954e-22 TargetScan;miRNATAP -0.146951557311177 3.2735325009382e-16 NA NA NA hsa-miR-141-3p KLHL20 2.99777540204168 1.26370498493024e-78 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.131933278614168 1.09740859260953e-24 NA NA NA hsa-miR-200a-3p KLHL20 2.55218480823434 2.96135446816238e-51 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.126435474737735 1.458203736018e-23 NA NA NA hsa-miR-200b-3p KLHL20 2.11744072703209 1.66710572104191e-43 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.135017451194605 9.47763581851314e-22 NA NA NA hsa-miR-200c-3p KLHL20 2.07038651806183 6.84613386286599e-51 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.159871356307668 3.57478729778656e-25 NA NA NA hsa-miR-429 KLHL20 2.84108892259147 3.88520896426515e-64 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate;miRanda;miRNATAP -0.126122614164373 9.11072361969323e-24 NA NA NA hsa-miR-182-5p KLHL21 2.36408084103818 2.60011457600281e-72 -1.22957893277866 1.10718515485697e-43 mirMAP -0.239669879051106 1.11171574130532e-28 NA NA NA hsa-miR-21-5p KLHL24 2.32007501846389 3.08394781855554e-137 -0.684917333400169 3.29659092408193e-18 miRNAWalker2_validate -0.246486780757483 4.3961308969267e-24 NA NA NA hsa-miR-200b-3p KLHL29 2.11744072703209 1.66710572104191e-43 -2.95396942574741 6.38249769037222e-85 MirTarget -0.376077414884347 1.59043473219451e-27 NA NA NA hsa-miR-200c-3p KLHL29 2.07038651806183 6.84613386286599e-51 -2.95396942574741 6.38249769037222e-85 MirTarget -0.489121323686625 6.23215473827391e-39 NA NA NA hsa-miR-429 KLHL29 2.84108892259147 3.88520896426515e-64 -2.95396942574741 6.38249769037222e-85 MirTarget;miRanda -0.387645756711163 5.52772543475208e-37 NA NA NA hsa-miR-182-5p KLHL3 2.36408084103818 2.60011457600281e-72 -1.42904846118913 3.36735011519996e-41 mirMAP -0.231274427339552 8.21062443100637e-19 NA NA NA hsa-miR-183-5p KLHL3 2.95681814393872 1.09965777344285e-92 -1.42904846118913 3.36735011519996e-41 miRNATAP -0.283455208948846 3.55062038075346e-36 NA NA NA hsa-miR-200b-3p KLHL3 2.11744072703209 1.66710572104191e-43 -1.42904846118913 3.36735011519996e-41 TargetScan;mirMAP -0.233013166053113 5.92243783156719e-24 NA NA NA hsa-miR-200c-3p KLHL3 2.07038651806183 6.84613386286599e-51 -1.42904846118913 3.36735011519996e-41 miRNATAP -0.319582667624024 1.31441831100076e-37 NA NA NA hsa-miR-429 KLHL3 2.84108892259147 3.88520896426515e-64 -1.42904846118913 3.36735011519996e-41 PITA;miRanda;miRNATAP -0.232441624985903 6.28097069585819e-30 NA NA NA hsa-miR-96-5p KLHL3 3.24596558166606 1.92296159041707e-98 -1.42904846118913 3.36735011519996e-41 mirMAP -0.251118766043711 4.08359405598015e-32 NA NA NA hsa-miR-200b-3p KLHL31 2.11744072703209 1.66710572104191e-43 -3.31721362350133 3.07495007926235e-88 MirTarget -0.403909945569104 5.90542127089379e-26 NA NA NA hsa-miR-200c-3p KLHL31 2.07038651806183 6.84613386286599e-51 -3.31721362350133 3.07495007926235e-88 MirTarget -0.499613453352171 5.6505973633548e-33 NA NA NA hsa-miR-429 KLHL31 2.84108892259147 3.88520896426515e-64 -3.31721362350133 3.07495007926235e-88 MirTarget;miRanda -0.394095697459818 4.64463998909476e-31 NA NA NA hsa-miR-335-5p KLHL35 -2.61355235628987 2.6462884165886e-51 1.84203573210849 3.47190064862329e-25 miRNAWalker2_validate -0.254114626467752 3.55456042539959e-14 NA NA NA hsa-miR-182-5p KLHL4 2.36408084103818 2.60011457600281e-72 -2.15138073969441 5.3868668795652e-36 mirMAP -0.427551458753948 8.76708577161579e-25 NA NA NA hsa-miR-21-5p KLHL4 2.32007501846389 3.08394781855554e-137 -2.15138073969441 5.3868668795652e-36 mirMAP -0.498491500551846 8.9233572459027e-20 NA NA NA hsa-miR-429 KLHL5 2.84108892259147 3.88520896426515e-64 -0.54670810805417 5.26860073240721e-09 miRanda -0.125485306027348 1.20900004639723e-12 NA NA NA hsa-miR-375 KLK10 2.09893673049766 1.68351780396203e-16 -2.24072052209129 1.86670067043124e-08 miRNAWalker2_validate -0.371857870433847 1.22019991068036e-12 NA NA NA hsa-miR-21-3p KLK11 2.17476065946878 5.15299442583591e-75 -2.62443788013531 1.65433416224631e-08 MirTarget -0.684853291845205 2.34601808101222e-08 24288670 The aim of our study was to monitor serum levels of two miRNAs miR-21 and miR-141 and three KLKs hK3/PSA hK11 and hK13 before and 1 5 and 30 days after radical prostatectomy in order to characterize their fluctuations after surgery; miR-21 and miR-141 were quantified through real-time PCR while ELISA assays were used to quantify hK3 PSA hK11 and hK13 prostate cancer hsa-miR-429 KLK2 2.84108892259147 3.88520896426515e-64 -1.04467746988355 0.000115942449650669 miRanda -0.209497968406164 4.58092157623892e-05 NA NA NA hsa-miR-183-5p KLRD1 2.95681814393872 1.09965777344285e-92 -0.812118463718237 4.46962893443659e-06 MirTarget -0.193575453160748 2.09579232332572e-07 NA NA NA hsa-miR-429 KLRF1 2.84108892259147 3.88520896426515e-64 -1.7972486362522 4.90034211016526e-20 miRanda -0.358574676835352 4.18447861091982e-22 NA NA NA hsa-miR-139-5p KPNA2 -3.25846663863766 2.62018989415003e-112 1.85652080082833 1.15486742223129e-52 miRanda -0.381679817325686 2.19406310197135e-52 NA NA NA hsa-miR-21-5p KRIT1 2.32007501846389 3.08394781855554e-137 -0.204721168461244 0.000225588388617869 miRNATAP -0.1616071583699 1.04658447551898e-21 NA NA NA hsa-miR-335-5p KRT19 -2.61355235628987 2.6462884165886e-51 2.68708500448964 1.7111429538766e-40 miRNAWalker2_validate -0.348147160514949 1.81386591593216e-19 NA NA NA hsa-miR-335-5p KRT4 -2.61355235628987 2.6462884165886e-51 0.618039930034658 0.0840840038549494 miRNAWalker2_validate -0.375828142713971 1.24367706584348e-08 NA NA NA hsa-miR-486-5p KRT8 -3.87258704301474 1.22658629378451e-80 2.40297967183275 4.16605405015516e-53 miRNATAP -0.296772270292463 6.01694745858123e-34 NA NA NA hsa-miR-335-5p KRT81 -2.61355235628987 2.6462884165886e-51 0.00730369072928072 0.984729222689675 MirTarget -0.331633636179617 2.59739821853931e-06 NA NA NA hsa-miR-200a-3p KSR1 2.55218480823434 2.96135446816238e-51 -0.85900089733364 7.21800600691212e-18 mirMAP -0.165442564406279 3.52469026490611e-18 NA NA NA hsa-miR-200b-3p KSR1 2.11744072703209 1.66710572104191e-43 -0.85900089733364 7.21800600691212e-18 TargetScan;mirMAP -0.179057737932812 2.93994721904487e-17 NA NA NA hsa-miR-200c-3p KSR1 2.07038651806183 6.84613386286599e-51 -0.85900089733364 7.21800600691212e-18 mirMAP -0.20351754656324 2.21229417566801e-18 NA NA NA hsa-miR-429 KSR1 2.84108892259147 3.88520896426515e-64 -0.85900089733364 7.21800600691212e-18 miRanda;mirMAP;miRNATAP -0.159332980084839 3.82878122343549e-17 NA NA NA hsa-miR-21-5p KSR2 2.32007501846389 3.08394781855554e-137 -0.0859402107200666 0.658608084265407 mirMAP -0.223089579565432 0.000225645228480768 NA NA NA hsa-miR-378a-5p KSR2 -2.43173551693523 1.44932837789175e-68 -0.0859402107200666 0.658608084265407 mirMAP -0.384577912006178 4.46444359111333e-19 NA NA NA hsa-miR-452-5p KSR2 -2.48486455572568 1.24430987974325e-33 -0.0859402107200666 0.658608084265407 mirMAP -0.288941755288498 1.56339993504313e-21 NA NA NA hsa-miR-375 KYNU 2.09893673049766 1.68351780396203e-16 -0.0218856240929535 0.91726010798386 miRanda -0.140832743680793 3.40857686359514e-07 NA NA NA hsa-miR-182-5p L1CAM 2.36408084103818 2.60011457600281e-72 -0.982619516708927 0.000146508335540534 MirTarget;miRNATAP -0.269529686470985 1.24641784587536e-05 NA NA NA hsa-miR-96-5p L1CAM 3.24596558166606 1.92296159041707e-98 -0.982619516708927 0.000146508335540534 TargetScan;miRNATAP -0.187352916244391 0.000257992513999239 NA NA NA hsa-miR-335-5p LAD1 -2.61355235628987 2.6462884165886e-51 1.40256787426387 1.63603674905194e-09 mirMAP -0.256899007065766 2.96109325216098e-09 NA NA NA hsa-miR-139-5p LAGE3 -3.25846663863766 2.62018989415003e-112 1.81910955219324 7.48601188318736e-58 miRanda -0.317825442205347 2.72628287584351e-40 NA NA NA hsa-miR-375 LAMA2 2.09893673049766 1.68351780396203e-16 -2.16756236589159 1.88679943487983e-31 miRanda -0.141366224796711 2.30583404419529e-08 NA NA NA hsa-miR-21-5p LAMA4 2.32007501846389 3.08394781855554e-137 -1.35277171982831 9.76622188586797e-36 MirTarget -0.249548681112465 8.17325028836981e-13 NA NA NA hsa-miR-429 LAMA4 2.84108892259147 3.88520896426515e-64 -1.35277171982831 9.76622188586797e-36 miRanda -0.307419941987586 8.34841968593741e-53 NA NA NA hsa-miR-182-5p LAMC1 2.36408084103818 2.60011457600281e-72 -1.22673201326814 1.35102621663939e-35 miRNATAP -0.279210293932062 2.59063689304366e-32 NA NA NA hsa-miR-200b-3p LAMC1 2.11744072703209 1.66710572104191e-43 -1.22673201326814 1.35102621663939e-35 MirTarget;TargetScan -0.289967230006364 9.75181041203852e-45 NA NA NA hsa-miR-200c-3p LAMC1 2.07038651806183 6.84613386286599e-51 -1.22673201326814 1.35102621663939e-35 MirTarget;miRNATAP -0.329360689529761 5.25538223517216e-48 NA NA NA hsa-miR-429 LAMC1 2.84108892259147 3.88520896426515e-64 -1.22673201326814 1.35102621663939e-35 MirTarget;PITA;miRanda;miRNATAP -0.250412580267939 1.24821064577774e-41 NA NA NA hsa-miR-96-5p LAMC1 3.24596558166606 1.92296159041707e-98 -1.22673201326814 1.35102621663939e-35 MirTarget;TargetScan;miRNATAP -0.258001814246817 1.73137300974635e-40 NA NA NA hsa-miR-375 LAMC2 2.09893673049766 1.68351780396203e-16 -1.62034326586173 2.05014148904585e-12 miRanda -0.225853976513003 1.07683110051097e-13 NA NA NA hsa-miR-375 LAMP3 2.09893673049766 1.68351780396203e-16 1.21714296693577 1.90210421863729e-08 miRanda -0.183998028363862 1.1115415040475e-10 NA NA NA hsa-miR-21-5p LANCL1 2.32007501846389 3.08394781855554e-137 -0.553726952789464 2.49149724458199e-16 MirTarget -0.271771727767269 1.56622389244692e-40 NA NA NA hsa-miR-21-5p LANCL3 2.32007501846389 3.08394781855554e-137 -1.09429866975585 1.04550480770136e-09 MirTarget -0.133909445712517 0.0177934102483431 NA NA NA hsa-miR-139-5p LAPTM4B -3.25846663863766 2.62018989415003e-112 0.777959934506498 9.03798977075e-09 miRanda -0.24946058615129 1.17368647007093e-19 NA NA NA hsa-miR-335-5p LAPTM5 -2.61355235628987 2.6462884165886e-51 0.693263784795249 7.58128267579307e-12 miRNAWalker2_validate -0.100252653038397 1.18770085830696e-07 NA NA NA hsa-miR-452-5p LARP4 -2.48486455572568 1.24430987974325e-33 0.342395135866956 1.01881181652413e-06 mirMAP -0.112354086300129 8.48373677911551e-25 NA NA NA hsa-miR-139-5p LARP4B -3.25846663863766 2.62018989415003e-112 0.460469789689195 9.26324714937959e-18 miRanda -0.101436501245995 2.68272224935726e-20 NA NA NA hsa-miR-375 LARP6 2.09893673049766 1.68351780396203e-16 -1.77743473863714 1.02889284986309e-47 miRanda -0.177222738985085 1.59815987434758e-26 NA NA NA hsa-miR-200c-3p LATS1 2.07038651806183 6.84613386286599e-51 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.129530797506882 6.79149629055103e-05 NA NA NA hsa-miR-21-5p LATS1 2.32007501846389 3.08394781855554e-137 -0.990266110404731 6.58107345321622e-13 miRNAWalker2_validate -0.341435277796525 1.60822085351667e-15 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-429 LATS1 2.84108892259147 3.88520896426515e-64 -0.990266110404731 6.58107345321622e-13 PITA;miRanda;miRNATAP -0.16445910331278 3.57904693957067e-10 NA NA NA hsa-miR-200b-3p LATS2 2.11744072703209 1.66710572104191e-43 -1.07930752603412 1.77477579396165e-33 TargetScan -0.242433743681395 1.08648777794347e-37 NA NA NA hsa-miR-200c-3p LATS2 2.07038651806183 6.84613386286599e-51 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.293619037542608 2.39755570299602e-46 NA NA NA hsa-miR-429 LATS2 2.84108892259147 3.88520896426515e-64 -1.07930752603412 1.77477579396165e-33 PITA;miRanda;miRNATAP -0.210085665924318 2.16730453894399e-35 NA NA NA hsa-miR-96-5p LATS2 3.24596558166606 1.92296159041707e-98 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.248313256795386 4.07672171830279e-46 NA NA NA hsa-miR-182-5p LBR 2.36408084103818 2.60011457600281e-72 -0.401779315698072 8.08554841411615e-05 miRNAWalker2_validate -0.176710636019528 1.94791046320204e-13 NA NA NA hsa-miR-200b-3p LBR 2.11744072703209 1.66710572104191e-43 -0.401779315698072 8.08554841411615e-05 MirTarget;TargetScan -0.115039708464663 9.46590658535492e-08 NA NA NA hsa-miR-200c-3p LBR 2.07038651806183 6.84613386286599e-51 -0.401779315698072 8.08554841411615e-05 MirTarget -0.102925368746776 1.49376510315715e-05 NA NA NA hsa-miR-375 LBR 2.09893673049766 1.68351780396203e-16 -0.401779315698072 8.08554841411615e-05 miRanda -0.125225974367861 1.83380369000825e-21 NA NA NA hsa-miR-200b-3p LCA5 2.11744072703209 1.66710572104191e-43 -1.52780832675301 1.59946395741852e-39 MirTarget;TargetScan -0.18891853841453 1.33170333214429e-13 NA NA NA hsa-miR-200c-3p LCA5 2.07038651806183 6.84613386286599e-51 -1.52780832675301 1.59946395741852e-39 MirTarget -0.236335642432034 2.59700880600913e-17 NA NA NA hsa-miR-429 LCA5 2.84108892259147 3.88520896426515e-64 -1.52780832675301 1.59946395741852e-39 MirTarget;miRanda;miRNATAP -0.225557265934553 1.11187513803367e-23 NA NA NA hsa-miR-21-5p LCOR 2.32007501846389 3.08394781855554e-137 -0.508194262602784 0.00275203953871125 mirMAP -0.245810794918492 3.21079880165693e-06 NA NA NA hsa-miR-452-5p LCOR -2.48486455572568 1.24430987974325e-33 -0.508194262602784 0.00275203953871125 mirMAP -0.14515036975589 7.67185558462574e-08 NA NA NA hsa-miR-21-5p LCORL 2.32007501846389 3.08394781855554e-137 -0.450688782390954 1.28333553846824e-07 miRNAWalker2_validate;miRNATAP -0.202563121918904 1.56767259134752e-14 NA NA NA hsa-miR-96-5p LDB2 3.24596558166606 1.92296159041707e-98 -2.24235549916864 1.49095364446973e-88 TargetScan;miRNATAP -0.398146714707668 3.82957092759415e-68 NA NA NA hsa-miR-429 LDB3 2.84108892259147 3.88520896426515e-64 -1.85025183125106 1.91109961605668e-38 miRanda;miRNATAP -0.322948998951846 2.50337996177688e-32 NA NA NA hsa-miR-375 LDHB 2.09893673049766 1.68351780396203e-16 -1.52355626193472 1.5585374854613e-22 miRNAWalker2_validate;miRanda;miRNATAP -0.253388433399967 5.87116849741788e-36 22752059 The restoration of miR-375 suppressed the expression of LDHB and AEG-1/MTDH; LDHB which is regulated by the tumor suppressive miR-375 may therefore act as an oncogene in ESCC esophageal cancer hsa-miR-429 LDLRAD2 2.84108892259147 3.88520896426515e-64 -0.634280477002227 8.88888752095322e-07 miRNATAP -0.14831702481891 1.1804811889579e-09 NA NA NA hsa-miR-452-5p LDLRAD3 -2.48486455572568 1.24430987974325e-33 0.233248859753568 0.0975746606682237 MirTarget;miRNATAP -0.174900562813006 2.77818955681254e-15 NA NA NA hsa-miR-326 LEF1 -1.54449030848141 1.04703417845594e-17 2.04129621040026 7.44253629249046e-48 miRanda -0.135291856721102 1.0203567859312e-06 NA NA NA hsa-miR-335-3p LEF1 -1.88448538773649 2.09538234398335e-32 2.04129621040026 7.44253629249046e-48 mirMAP -0.25656991808437 2.69608203703196e-17 NA NA NA hsa-miR-335-5p LEMD2 -2.61355235628987 2.6462884165886e-51 0.741847692462196 1.78185345183244e-31 mirMAP -0.11065799757016 2.45195436904458e-20 NA NA NA hsa-miR-21-5p LEMD3 2.32007501846389 3.08394781855554e-137 -0.276162296999045 4.21811726542356e-06 miRNATAP -0.143176877310001 9.35508155432617e-15 NA NA NA hsa-miR-10b-5p LENG1 -2.10996264627796 7.36811595736367e-72 0.614343964293659 7.07618501346702e-08 mirMAP -0.145952374209995 1.66257801538941e-06 NA NA NA hsa-miR-183-5p LENG8 2.95681814393872 1.09965777344285e-92 -0.462383061991931 9.80524914005011e-07 miRNAWalker2_validate -0.11420714804335 8.97070004610934e-09 NA NA NA hsa-miR-375 LEP 2.09893673049766 1.68351780396203e-16 -7.67518473730639 1.72637364788671e-75 mirMAP -0.357295375224867 2.79170660849737e-09 NA NA NA hsa-miR-429 LEPR 2.84108892259147 3.88520896426515e-64 -3.24143926522135 2.40158609979225e-92 miRanda;miRNATAP -0.483071748248401 2.53285744438158e-52 NA NA NA hsa-miR-335-5p LGALS9B -2.61355235628987 2.6462884165886e-51 1.91439024196323 3.67033056566434e-11 miRNAWalker2_validate -0.216737542909721 6.53373336167493e-05 NA NA NA hsa-miR-335-5p LGALS9C -2.61355235628987 2.6462884165886e-51 1.31806082574292 3.46085460767654e-14 miRNAWalker2_validate -0.162164975371577 6.89360188421407e-07 NA NA NA hsa-miR-182-5p LGI1 2.36408084103818 2.60011457600281e-72 -2.19372584538264 2.04380263555319e-14 miRNATAP -0.378487797697691 4.20283228021699e-08 NA NA NA hsa-miR-429 LGI1 2.84108892259147 3.88520896426515e-64 -2.19372584538264 2.04380263555319e-14 miRanda -0.365893486255217 2.14014290685221e-11 NA NA NA hsa-miR-96-5p LGI1 3.24596558166606 1.92296159041707e-98 -2.19372584538264 2.04380263555319e-14 TargetScan;miRNATAP -0.425918417796698 6.77460713485643e-14 NA NA NA hsa-miR-141-3p LGR4 2.99777540204168 1.26370498493024e-78 -1.80154760191776 1.78479409180551e-31 MirTarget -0.264897230344887 4.65652574443527e-18 NA NA NA hsa-miR-200a-3p LGR4 2.55218480823434 2.96135446816238e-51 -1.80154760191776 1.78479409180551e-31 MirTarget -0.209678681673349 4.11420862464218e-12 NA NA NA hsa-miR-429 LGR4 2.84108892259147 3.88520896426515e-64 -1.80154760191776 1.78479409180551e-31 miRanda -0.205559265699574 7.85921281189479e-12 NA NA NA hsa-miR-375 LGR5 2.09893673049766 1.68351780396203e-16 -0.973708966607494 0.00028496921350823 miRanda -0.213386920777125 1.35367541756069e-09 NA NA NA hsa-miR-141-3p LHFP 2.99777540204168 1.26370498493024e-78 -2.16259674677525 1.67757586200326e-80 MirTarget -0.477450630254742 4.1465893838156e-111 NA NA NA hsa-miR-200a-3p LHFP 2.55218480823434 2.96135446816238e-51 -2.16259674677525 1.67757586200326e-80 MirTarget -0.381959827138675 6.75463351007796e-67 NA NA NA hsa-miR-200b-3p LHFP 2.11744072703209 1.66710572104191e-43 -2.16259674677525 1.67757586200326e-80 MirTarget;TargetScan -0.394555356349039 1.80094021057247e-56 NA NA NA hsa-miR-200c-3p LHFP 2.07038651806183 6.84613386286599e-51 -2.16259674677525 1.67757586200326e-80 MirTarget;miRNATAP -0.506967020020484 2.61318210948237e-81 NA NA NA hsa-miR-429 LHFP 2.84108892259147 3.88520896426515e-64 -2.16259674677525 1.67757586200326e-80 MirTarget;PITA;miRanda;miRNATAP -0.385142985685175 2.60131788225477e-69 NA NA NA hsa-miR-183-5p LHFPL2 2.95681814393872 1.09965777344285e-92 -0.536516355235196 1.10314108197249e-10 MirTarget -0.136826237708584 4.12342496140608e-15 NA NA NA hsa-miR-429 LHFPL2 2.84108892259147 3.88520896426515e-64 -0.536516355235196 1.10314108197249e-10 PITA;miRanda;miRNATAP -0.107669684176165 7.69965836412857e-12 NA NA NA hsa-miR-337-3p LHFPL5 -2.14274617598363 2.70942896809734e-43 2.63235241898409 3.08482588573377e-19 MirTarget -0.214544584603172 0.000629085592929474 NA NA NA hsa-miR-139-5p LHX1 -3.25846663863766 2.62018989415003e-112 1.38785993594482 4.82966987792261e-07 miRNATAP -0.246283522839765 1.5422310169906e-05 NA NA NA hsa-miR-141-3p LHX6 2.99777540204168 1.26370498493024e-78 -1.95178533559281 6.99624188227914e-45 MirTarget;TargetScan;miRNATAP -0.345799790693977 9.78708001789682e-37 NA NA NA hsa-miR-200a-3p LHX6 2.55218480823434 2.96135446816238e-51 -1.95178533559281 6.99624188227914e-45 MirTarget;miRNATAP -0.282409210833886 3.04283998577957e-25 NA NA NA hsa-miR-429 LHX6 2.84108892259147 3.88520896426515e-64 -1.95178533559281 6.99624188227914e-45 miRNATAP -0.270308222511878 1.86000498193333e-23 NA NA NA hsa-miR-141-3p LIF 2.99777540204168 1.26370498493024e-78 -0.905887057866458 4.87585212725247e-08 mirMAP -0.209274341605771 8.13949251394338e-11 NA NA NA hsa-miR-200a-3p LIF 2.55218480823434 2.96135446816238e-51 -0.905887057866458 4.87585212725247e-08 mirMAP -0.141099841954999 9.16221284800043e-06 NA NA NA hsa-miR-182-5p LIFR 2.36408084103818 2.60011457600281e-72 -3.04175429528162 6.69458064740976e-81 mirMAP -0.387254780967205 5.1668024342183e-21 NA NA NA hsa-miR-21-5p LIFR 2.32007501846389 3.08394781855554e-137 -3.04175429528162 6.69458064740976e-81 miRNAWalker2_validate -0.845255051722729 1.67109223795086e-61 NA NA NA hsa-miR-429 LIFR 2.84108892259147 3.88520896426515e-64 -3.04175429528162 6.69458064740976e-81 miRanda -0.419771299608504 1.90312382606979e-39 NA NA NA hsa-miR-96-5p LIFR 3.24596558166606 1.92296159041707e-98 -3.04175429528162 6.69458064740976e-81 mirMAP -0.442898805496316 2.33509823126837e-40 NA NA NA hsa-miR-139-5p LIG3 -3.25846663863766 2.62018989415003e-112 0.890423193789273 8.54220912136723e-34 miRanda -0.16348260370326 9.3634690283852e-27 NA NA NA hsa-miR-335-5p LILRB4 -2.61355235628987 2.6462884165886e-51 1.06289470693883 1.2176400696939e-15 miRNAWalker2_validate -0.165456971805053 2.76106194084715e-11 NA NA NA hsa-miR-429 LIMA1 2.84108892259147 3.88520896426515e-64 -0.866286956606686 6.12648261645244e-20 miRanda;miRNATAP -0.190730780594987 8.5580444614508e-27 NA NA NA hsa-miR-141-3p LIMCH1 2.99777540204168 1.26370498493024e-78 -1.49698446901643 1.67451218303074e-25 MirTarget -0.285198178764424 1.94884171624795e-24 NA NA NA hsa-miR-182-5p LIMCH1 2.36408084103818 2.60011457600281e-72 -1.49698446901643 1.67451218303074e-25 MirTarget;miRNATAP -0.190047255301307 5.75948046428997e-08 NA NA NA hsa-miR-200a-3p LIMCH1 2.55218480823434 2.96135446816238e-51 -1.49698446901643 1.67451218303074e-25 MirTarget -0.259449235149436 4.6308015188002e-21 NA NA NA hsa-miR-200a-5p LIMCH1 2.58844508672328 1.79650654234569e-56 -1.49698446901643 1.67451218303074e-25 MirTarget -0.235550478377408 1.03153184399643e-16 NA NA NA hsa-miR-21-5p LIMCH1 2.32007501846389 3.08394781855554e-137 -1.49698446901643 1.67451218303074e-25 miRNAWalker2_validate -0.430707850350701 1.03146170070126e-21 NA NA NA hsa-miR-429 LIMCH1 2.84108892259147 3.88520896426515e-64 -1.49698446901643 1.67451218303074e-25 miRNATAP -0.258526370953229 3.39355272289493e-21 NA NA NA hsa-miR-10b-5p LIMD2 -2.10996264627796 7.36811595736367e-72 1.39487119988144 3.48543580804385e-22 mirMAP -0.311745674583426 8.76081086510048e-16 NA NA NA hsa-miR-335-5p LIMD2 -2.61355235628987 2.6462884165886e-51 1.39487119988144 3.48543580804385e-22 mirMAP -0.185648227580109 8.20223885306752e-12 NA NA NA hsa-miR-182-5p LIMS1 2.36408084103818 2.60011457600281e-72 -0.735204843227455 1.74559562117541e-08 MirTarget;miRNATAP -0.177928771902031 1.07707197592698e-08 NA NA NA hsa-miR-429 LIMS1 2.84108892259147 3.88520896426515e-64 -0.735204843227455 1.74559562117541e-08 miRanda;miRNATAP -0.178218609143444 4.25257913672146e-13 NA NA NA hsa-miR-96-5p LIMS1 3.24596558166606 1.92296159041707e-98 -0.735204843227455 1.74559562117541e-08 TargetScan;miRNATAP -0.164964362284186 1.50344564555283e-10 NA NA NA hsa-miR-429 LIMS2 2.84108892259147 3.88520896426515e-64 -2.05692853958576 7.85881904967283e-70 miRNATAP -0.30135639741492 2.45586964998482e-39 NA NA NA hsa-miR-452-5p LIN7A -2.48486455572568 1.24430987974325e-33 -1.31657196533726 3.34635909206073e-07 mirMAP -0.111961366269578 0.00702279037426733 NA NA NA hsa-miR-21-5p LIN7C 2.32007501846389 3.08394781855554e-137 -0.150181682750527 0.00995775348936283 miRNAWalker2_validate -0.138450876623172 8.96827316055791e-15 NA NA NA hsa-miR-139-5p LIN9 -3.25846663863766 2.62018989415003e-112 0.738685825466139 1.66586818240146e-14 miRanda -0.188056939117337 1.02285902655394e-21 NA NA NA hsa-miR-335-5p LINGO3 -2.61355235628987 2.6462884165886e-51 1.72107734310706 6.9816534462798e-11 miRNAWalker2_validate -0.177958147579535 0.00032826113847518 NA NA NA hsa-miR-429 LIPE 2.84108892259147 3.88520896426515e-64 -4.2711618761235 5.59802219281331e-80 miRanda -0.589555791847115 4.6557200927609e-39 NA NA NA hsa-miR-96-5p LIPG 3.24596558166606 1.92296159041707e-98 -0.331963935858432 0.103976352571346 TargetScan -0.147604298592802 0.000250101401369138 NA NA NA hsa-miR-200b-3p LIX1L 2.11744072703209 1.66710572104191e-43 -1.12191838165483 1.88841382470153e-38 MirTarget -0.256581363994834 3.9895838092601e-45 NA NA NA hsa-miR-200c-3p LIX1L 2.07038651806183 6.84613386286599e-51 -1.12191838165483 1.88841382470153e-38 MirTarget -0.319830545669049 1.33157789728019e-59 NA NA NA hsa-miR-429 LIX1L 2.84108892259147 3.88520896426515e-64 -1.12191838165483 1.88841382470153e-38 MirTarget -0.215668043411221 1.23784876908528e-39 NA NA NA hsa-miR-335-5p LLGL2 -2.61355235628987 2.6462884165886e-51 2.09596517714534 6.31091585684175e-69 miRNAWalker2_validate -0.256077448580076 8.45877704963449e-28 NA NA NA hsa-miR-99a-5p LMAN2 -2.25079447371102 1.14086813185885e-54 1.00801505718904 1.27009625914081e-37 miRNAWalker2_validate -0.190246248383147 4.78651486693028e-27 NA NA NA hsa-miR-429 LMBRD1 2.84108892259147 3.88520896426515e-64 -0.804149027533146 2.18750434275297e-36 miRanda -0.113575214696582 3.58057418918009e-20 NA NA NA hsa-miR-10b-5p LMF2 -2.10996264627796 7.36811595736367e-72 0.388314833921403 1.54245555083964e-06 miRNAWalker2_validate -0.186227993673136 1.57945502900526e-18 NA NA NA hsa-miR-429 LMO2 2.84108892259147 3.88520896426515e-64 -1.21063100853947 1.57846048990279e-43 miRanda -0.212371877539736 6.19431225753306e-37 NA NA NA hsa-miR-141-3p LMO3 2.99777540204168 1.26370498493024e-78 -2.66323880191004 4.12753530011824e-26 MirTarget;TargetScan -0.287667089187095 1.00382042979226e-08 NA NA NA hsa-miR-183-5p LMO3 2.95681814393872 1.09965777344285e-92 -2.66323880191004 4.12753530011824e-26 miRNATAP -0.331652886502888 1.0509163490691e-09 NA NA NA hsa-miR-200a-3p LMO3 2.55218480823434 2.96135446816238e-51 -2.66323880191004 4.12753530011824e-26 MirTarget -0.268317355069568 5.25443338994674e-08 NA NA NA hsa-miR-486-5p LMO7 -3.87258704301474 1.22658629378451e-80 0.687476619461621 1.22943039590259e-09 miRanda -0.108626248177663 2.63626286416714e-10 NA NA NA hsa-miR-182-5p LMOD1 2.36408084103818 2.60011457600281e-72 -2.92260102467088 6.24028357398509e-81 miRNATAP -0.478572591318356 6.76324580458813e-35 NA NA NA hsa-miR-429 LMOD1 2.84108892259147 3.88520896426515e-64 -2.92260102467088 6.24028357398509e-81 miRNATAP -0.446536817381014 3.6984018594309e-49 NA NA NA hsa-miR-96-5p LMOD1 3.24596558166606 1.92296159041707e-98 -2.92260102467088 6.24028357398509e-81 TargetScan;miRNATAP -0.516538069557595 6.57688951252842e-62 NA NA NA hsa-miR-141-3p LMOD3 2.99777540204168 1.26370498493024e-78 -0.439617445770009 0.0129847801223693 miRNATAP -0.108064708361408 0.00168942549546329 NA NA NA hsa-miR-139-3p LMTK3 -3.44089023199323 1.67292890850702e-91 1.68912435694034 2.03163275040597e-18 miRNATAP -0.189778838461172 7.9622189584375e-08 NA NA NA hsa-miR-429 LMX1A 2.84108892259147 3.88520896426515e-64 -2.77632845503796 2.08515392922338e-35 miRNATAP -0.464972233798174 2.03607668210998e-27 NA NA NA hsa-miR-378a-5p LMX1B -2.43173551693523 1.44932837789175e-68 0.889964138391244 7.40589152986158e-06 mirMAP -0.657708383299542 1.10797139873909e-54 NA NA NA hsa-miR-200b-3p LNPEP 2.11744072703209 1.66710572104191e-43 -0.989631439347203 8.70205363760698e-12 mirMAP -0.221281418752689 6.13972471409315e-13 NA NA NA hsa-miR-200c-3p LNPEP 2.07038651806183 6.84613386286599e-51 -0.989631439347203 8.70205363760698e-12 mirMAP -0.207461171988358 9.93945764825925e-10 NA NA NA hsa-miR-21-5p LNPEP 2.32007501846389 3.08394781855554e-137 -0.989631439347203 8.70205363760698e-12 mirMAP -0.320312961380251 1.37367553783526e-12 NA NA NA hsa-miR-429 LNPEP 2.84108892259147 3.88520896426515e-64 -0.989631439347203 8.70205363760698e-12 mirMAP;miRNATAP -0.207250092282521 4.00665551444302e-14 NA NA NA hsa-miR-429 LONRF1 2.84108892259147 3.88520896426515e-64 -0.948670906860738 3.66640535641739e-30 miRNATAP -0.129375571678252 7.69128716693763e-16 NA NA NA hsa-miR-21-3p LONRF2 2.17476065946878 5.15299442583591e-75 -0.371952863448676 0.158204061980662 mirMAP -0.364806277054691 1.23088393871166e-07 NA NA NA hsa-miR-21-5p LONRF2 2.32007501846389 3.08394781855554e-137 -0.371952863448676 0.158204061980662 miRNAWalker2_validate -0.314063567115019 0.000127917502824947 NA NA NA hsa-miR-224-5p LONRF2 -2.22249420723892 1.07787949391113e-18 -0.371952863448676 0.158204061980662 mirMAP -0.416771985708289 2.44492523233115e-35 NA NA NA hsa-miR-200b-3p LOX 2.11744072703209 1.66710572104191e-43 -0.342212996476533 0.0205578562983786 TargetScan -0.302299111361363 4.30683884623164e-23 NA NA NA hsa-miR-429 LOX 2.84108892259147 3.88520896426515e-64 -0.342212996476533 0.0205578562983786 miRanda;miRNATAP -0.222414643156444 6.65145132416868e-16 NA NA NA hsa-miR-335-5p LOXL1 -2.61355235628987 2.6462884165886e-51 1.49728597567933 5.44851508051121e-34 miRNAWalker2_validate -0.190396935804745 4.84447831217183e-16 NA NA NA hsa-miR-200b-3p LPAR1 2.11744072703209 1.66710572104191e-43 -1.20736956265381 1.93522163393847e-21 MirTarget;TargetScan -0.30751425904766 7.7026883287757e-31 NA NA NA hsa-miR-200c-3p LPAR1 2.07038651806183 6.84613386286599e-51 -1.20736956265381 1.93522163393847e-21 miRNAWalker2_validate;MirTarget;miRNATAP -0.351153536982569 2.48589736261259e-33 NA NA NA hsa-miR-429 LPAR1 2.84108892259147 3.88520896426515e-64 -1.20736956265381 1.93522163393847e-21 MirTarget;miRanda;miRNATAP -0.284902325794861 2.8630305499812e-33 NA NA NA hsa-miR-429 LPAR4 2.84108892259147 3.88520896426515e-64 -0.744328364270219 1.68304940061366e-07 miRNATAP -0.242512654278231 6.52512137164503e-20 NA NA NA hsa-miR-139-5p LPCAT1 -3.25846663863766 2.62018989415003e-112 1.21997647654287 3.56600287518414e-42 miRanda -0.192607466009869 2.20676256292877e-24 NA NA NA hsa-miR-335-5p LPCAT1 -2.61355235628987 2.6462884165886e-51 1.21997647654287 3.56600287518414e-42 miRNAWalker2_validate -0.142842058127022 1.14455765037472e-16 NA NA NA hsa-miR-429 LPCAT2 2.84108892259147 3.88520896426515e-64 -1.47495293212496 2.54237167912295e-41 miRanda -0.211240735757654 3.02681045406153e-23 NA NA NA hsa-miR-200b-3p LPIN1 2.11744072703209 1.66710572104191e-43 -1.24151990954073 9.74525630325401e-28 MirTarget;TargetScan -0.155610280257861 3.0608796471282e-10 NA NA NA hsa-miR-200c-3p LPIN1 2.07038651806183 6.84613386286599e-51 -1.24151990954073 9.74525630325401e-28 MirTarget -0.174395403814388 1.36919873659418e-10 NA NA NA hsa-miR-429 LPIN1 2.84108892259147 3.88520896426515e-64 -1.24151990954073 9.74525630325401e-28 MirTarget;miRanda;miRNATAP -0.11552867366272 1.83670601010085e-07 NA NA NA hsa-miR-141-3p LPP 2.99777540204168 1.26370498493024e-78 -1.17035459588915 3.47523383485479e-19 TargetScan;miRNATAP -0.171778131081795 2.36177347868105e-11 NA NA NA hsa-miR-182-5p LPP 2.36408084103818 2.60011457600281e-72 -1.17035459588915 3.47523383485479e-19 MirTarget;miRNATAP -0.156868477054836 7.48791204089103e-07 NA NA NA hsa-miR-200a-3p LPP 2.55218480823434 2.96135446816238e-51 -1.17035459588915 3.47523383485479e-19 miRNATAP -0.160894655353184 1.87353047391844e-10 NA NA NA hsa-miR-21-3p LPP 2.17476065946878 5.15299442583591e-75 -1.17035459588915 3.47523383485479e-19 mirMAP -0.118463243891356 0.000753376623635771 NA NA NA hsa-miR-21-5p LPP 2.32007501846389 3.08394781855554e-137 -1.17035459588915 3.47523383485479e-19 mirMAP -0.346769488596522 2.26455556670428e-17 NA NA NA hsa-miR-429 LPP 2.84108892259147 3.88520896426515e-64 -1.17035459588915 3.47523383485479e-19 miRanda;miRNATAP -0.174172735016139 3.38987894423591e-12 NA NA NA hsa-miR-96-5p LPP 3.24596558166606 1.92296159041707e-98 -1.17035459588915 3.47523383485479e-19 TargetScan;miRNATAP -0.184861753517396 1.43042537132224e-12 NA NA NA hsa-miR-182-5p LRCH1 2.36408084103818 2.60011457600281e-72 -0.845603029773804 1.79105003827433e-30 MirTarget -0.15542362442401 3.08224636742542e-18 NA NA NA hsa-miR-429 LRCH1 2.84108892259147 3.88520896426515e-64 -0.845603029773804 1.79105003827433e-30 miRanda;miRNATAP -0.159830333205409 2.41279420485443e-30 NA NA NA hsa-miR-182-5p LRCH2 2.36408084103818 2.60011457600281e-72 -1.81531257152895 1.63762941420744e-37 miRNATAP -0.391847362550232 1.78250919994207e-30 NA NA NA hsa-miR-429 LRCH2 2.84108892259147 3.88520896426515e-64 -1.81531257152895 1.63762941420744e-37 miRanda;miRNATAP -0.356281762182341 2.46124344226197e-40 NA NA NA hsa-miR-96-5p LRCH2 3.24596558166606 1.92296159041707e-98 -1.81531257152895 1.63762941420744e-37 MirTarget;TargetScan;miRNATAP -0.39934352737637 5.03315021215249e-47 NA NA NA hsa-miR-429 LRFN5 2.84108892259147 3.88520896426515e-64 -2.79159754665698 6.39216032400886e-40 miRanda -0.498423275369678 3.88118083514349e-35 NA NA NA hsa-miR-200b-3p LRP1 2.11744072703209 1.66710572104191e-43 -1.59623069924697 7.26581692175772e-39 TargetScan -0.390913060990931 5.87625867888281e-53 NA NA NA hsa-miR-429 LRP1 2.84108892259147 3.88520896426515e-64 -1.59623069924697 7.26581692175772e-39 PITA;miRanda;miRNATAP -0.354221946366701 1.0201391252e-54 NA NA NA hsa-miR-378a-5p LRP10 -2.43173551693523 1.44932837789175e-68 -0.0382360620439677 0.56834890677188 mirMAP -0.109679578245274 2.03708369057139e-13 NA NA NA hsa-miR-182-5p LRP12 2.36408084103818 2.60011457600281e-72 -0.484780529634142 5.28649737255221e-05 MirTarget -0.210623307080431 9.49431331766957e-14 NA NA NA hsa-miR-429 LRP12 2.84108892259147 3.88520896426515e-64 -0.484780529634142 5.28649737255221e-05 miRanda;miRNATAP -0.113439689543819 5.69367057347573e-07 NA NA NA hsa-miR-141-3p LRP1B 2.99777540204168 1.26370498493024e-78 -2.7905733237308 1.12458327034934e-14 TargetScan -0.521764006550357 1.2987696393109e-13 NA NA NA hsa-miR-183-5p LRP1B 2.95681814393872 1.09965777344285e-92 -2.7905733237308 1.12458327034934e-14 miRNATAP -0.5420549799834 1.36410923970609e-12 NA NA NA hsa-miR-196a-5p LRP1B 2.33423717464504 3.646557504928e-18 -2.7905733237308 1.12458327034934e-14 miRNATAP -0.171808564253788 0.000173077114742254 NA NA NA hsa-miR-200b-3p LRP1B 2.11744072703209 1.66710572104191e-43 -2.7905733237308 1.12458327034934e-14 MirTarget;TargetScan -0.416901322444173 7.36037135056929e-08 NA NA NA hsa-miR-200c-3p LRP1B 2.07038651806183 6.84613386286599e-51 -2.7905733237308 1.12458327034934e-14 MirTarget;miRNATAP -0.484532815827396 1.23933302299042e-08 NA NA NA hsa-miR-429 LRP1B 2.84108892259147 3.88520896426515e-64 -2.7905733237308 1.12458327034934e-14 MirTarget;PITA;miRanda;miRNATAP -0.488616084054642 1.16953750353084e-12 NA NA NA hsa-miR-196a-5p LRP2 2.33423717464504 3.646557504928e-18 -0.807564034442771 0.0466284114536984 miRNAWalker2_validate -0.193350664591136 0.00013116047596679 NA NA NA hsa-miR-200b-3p LRP4 2.11744072703209 1.66710572104191e-43 -1.80859309249455 1.72412102466362e-32 MirTarget;TargetScan -0.331471081272014 4.13021317654035e-24 NA NA NA hsa-miR-200c-3p LRP4 2.07038651806183 6.84613386286599e-51 -1.80859309249455 1.72412102466362e-32 MirTarget;miRNATAP -0.350262615415016 2.74986232400513e-22 NA NA NA hsa-miR-429 LRP4 2.84108892259147 3.88520896426515e-64 -1.80859309249455 1.72412102466362e-32 MirTarget;PITA;miRanda;miRNATAP -0.347857621683397 1.92465331066138e-33 NA NA NA hsa-miR-15a-5p LRP6 0.812445324157528 4.50263417099822e-20 -0.895655960628118 1.2216636698693e-21 miRNATAP -0.248475041752213 6.11710404479044e-12 NA NA NA hsa-miR-16-1-3p LRP6 1.30142784811196 2.53343713753744e-29 -0.895655960628118 1.2216636698693e-21 mirMAP -0.106034973608583 0.000270497356573657 NA NA NA hsa-miR-181a-5p LRP6 0.635863607630183 6.72486918157744e-11 -0.895655960628118 1.2216636698693e-21 mirMAP -0.121798217084118 0.000280419813406394 NA NA NA hsa-miR-181b-5p LRP6 1.22749257795094 1.21998198830919e-27 -0.895655960628118 1.2216636698693e-21 mirMAP -0.116284631040285 3.90842230631843e-05 NA NA NA hsa-miR-182-5p LRP6 2.36408084103818 2.60011457600281e-72 -0.895655960628118 1.2216636698693e-21 mirMAP -0.130168955655354 1.02975819358864e-08 NA NA NA hsa-miR-183-5p LRP6 2.95681814393872 1.09965777344285e-92 -0.895655960628118 1.2216636698693e-21 miRNATAP -0.108472989759681 7.08115025900927e-08 24289859 MicroRNA 183 suppresses retinoblastoma cell growth invasion and migration by targeting LRP6; These results indicate that miR-183 targets and downregulates LRP6 in the growth migration and invasion of RB cells retinoblastoma hsa-miR-29c-3p LRP6 -0.0652732378039769 0.563774115756922 -0.895655960628118 1.2216636698693e-21 miRNATAP -0.208977926908057 4.45236680313107e-13 NA NA NA hsa-miR-96-5p LRP6 3.24596558166606 1.92296159041707e-98 -0.895655960628118 1.2216636698693e-21 TargetScan;miRNATAP -0.11391896975426 1.48551831367243e-09 NA NA NA hsa-miR-10b-5p LRRC14 -2.10996264627796 7.36811595736367e-72 0.640315896061971 1.34396129102918e-16 mirMAP -0.198557641692265 3.22725469912675e-22 NA NA NA hsa-miR-224-5p LRRC15 -2.22249420723892 1.07787949391113e-18 3.53392343171925 7.8456170163519e-53 mirMAP -0.169795004694771 2.01025878841557e-07 NA NA NA hsa-miR-429 LRRC17 2.84108892259147 3.88520896426515e-64 -0.526098447402457 0.00602617191344875 miRanda -0.294234078412032 1.70529659373471e-16 NA NA NA hsa-miR-224-5p LRRC27 -2.22249420723892 1.07787949391113e-18 0.371914716525773 3.80448230629096e-06 mirMAP -0.117973589619973 5.714335906615e-30 NA NA NA hsa-miR-96-5p LRRC3 3.24596558166606 1.92296159041707e-98 -0.673505504298231 5.56777144850454e-10 TargetScan -0.163205441404401 2.1959291268019e-14 NA NA NA hsa-miR-429 LRRC32 2.84108892259147 3.88520896426515e-64 -0.64125533587963 1.96173907954692e-08 miRanda -0.236453500626721 3.08049282735928e-29 NA NA NA hsa-miR-429 LRRC34 2.84108892259147 3.88520896426515e-64 -1.24358593246451 1.68880654296469e-34 miRanda -0.152737271799107 1.06362245593583e-14 NA NA NA hsa-miR-141-5p LRRC4 2.38411349683216 4.56310582620282e-58 -0.159254343713705 0.166841438975842 miRNATAP -0.105343670796897 1.92183591787134e-05 NA NA NA hsa-miR-10b-5p LRRC59 -2.10996264627796 7.36811595736367e-72 1.15888617367301 7.7078165916983e-39 miRNAWalker2_validate -0.277101032855429 5.92165997574281e-31 NA NA NA hsa-miR-429 LRRC8C 2.84108892259147 3.88520896426515e-64 -1.31656441927558 1.0331692453585e-36 miRanda;miRNATAP -0.216693811176185 1.88724905516265e-27 NA NA NA hsa-miR-429 LRRIQ1 2.84108892259147 3.88520896426515e-64 -1.09956597458667 3.68064296681146e-05 miRanda -0.12542341623562 0.0134033419709675 NA NA NA hsa-miR-429 LRRK2 2.84108892259147 3.88520896426515e-64 -1.48401684997868 5.33841499677685e-22 miRanda;miRNATAP -0.292976912414673 8.35406917531858e-24 NA NA NA hsa-miR-375 LRRN4 2.09893673049766 1.68351780396203e-16 -0.503728500666719 0.0217590514644291 miRanda -0.126541134438762 1.18033235605568e-05 NA NA NA hsa-miR-141-3p LRRTM2 2.99777540204168 1.26370498493024e-78 -3.13984867257332 7.15618649621249e-76 miRNATAP -0.542374867357902 1.81770437630689e-57 NA NA NA hsa-miR-200a-3p LRRTM2 2.55218480823434 2.96135446816238e-51 -3.13984867257332 7.15618649621249e-76 miRNATAP -0.429652576186034 4.09960647196162e-36 NA NA NA hsa-miR-429 LRRTM2 2.84108892259147 3.88520896426515e-64 -3.13984867257332 7.15618649621249e-76 miRNATAP -0.451054848722542 1.33234418309952e-40 NA NA NA hsa-miR-141-3p LSAMP 2.99777540204168 1.26370498493024e-78 -0.782586811384943 0.000316660451492277 TargetScan -0.317167092175689 3.07332336359974e-14 NA NA NA hsa-miR-139-5p LSG1 -3.25846663863766 2.62018989415003e-112 0.495478608188627 2.97182245564909e-22 MirTarget;miRanda -0.126110349841712 2.69082342811204e-34 NA NA NA hsa-miR-139-5p LSM1 -3.25846663863766 2.62018989415003e-112 0.755429917891074 3.0213783323248e-13 miRanda -0.135605324769402 2.45557109286721e-10 NA NA NA hsa-miR-139-5p LSM14B -3.25846663863766 2.62018989415003e-112 0.882411641763935 1.20708753581714e-46 miRanda -0.176213811455455 9.63393429224558e-44 NA NA NA hsa-miR-139-5p LTA -3.25846663863766 2.62018989415003e-112 1.32321023330418 8.46390110512277e-11 miRanda -0.203119080210044 1.5376671513199e-06 NA NA NA hsa-miR-141-3p LTBP1 2.99777540204168 1.26370498493024e-78 -0.181835521424575 0.143896069693686 MirTarget -0.14099266757721 4.14111813979571e-09 NA NA NA hsa-miR-200a-3p LTBP1 2.55218480823434 2.96135446816238e-51 -0.181835521424575 0.143896069693686 MirTarget -0.155545472524258 3.39347655502809e-11 NA NA NA hsa-miR-182-5p LUZP1 2.36408084103818 2.60011457600281e-72 -0.862347696197524 1.67767614204943e-32 mirMAP;miRNATAP -0.174296135781522 2.55828079401204e-23 NA NA NA hsa-miR-96-5p LUZP1 3.24596558166606 1.92296159041707e-98 -0.862347696197524 1.67767614204943e-32 MirTarget;TargetScan;miRNATAP -0.181337338680484 5.85567253296276e-37 NA NA NA hsa-miR-429 LUZP2 2.84108892259147 3.88520896426515e-64 -3.05719575520513 5.28830387813607e-30 miRanda -0.520375214803743 4.05412350131431e-24 NA NA NA hsa-miR-335-5p LY6H -2.61355235628987 2.6462884165886e-51 2.3046307796348 1.88431357016982e-29 miRNAWalker2_validate -0.277043793412971 1.07511828307734e-12 NA NA NA hsa-miR-429 LY75 2.84108892259147 3.88520896426515e-64 -1.43422319381097 7.33486161412659e-18 miRanda;miRNATAP -0.120207512501358 0.000185818563362901 NA NA NA hsa-miR-429 LY96 2.84108892259147 3.88520896426515e-64 -0.238932542171537 0.0191014495425335 miRanda -0.125835456533555 4.59348203111087e-11 NA NA NA hsa-miR-141-5p LYNX1 2.38411349683216 4.56310582620282e-58 -1.57697299625608 1.92443262169204e-17 mirMAP -0.30391308020661 3.41907801453236e-14 NA NA NA hsa-miR-21-3p LYNX1 2.17476065946878 5.15299442583591e-75 -1.57697299625608 1.92443262169204e-17 mirMAP -0.286796237346698 6.78573492811123e-09 NA NA NA hsa-miR-486-5p LYPD1 -3.87258704301474 1.22658629378451e-80 2.00869068525594 1.49382831786523e-35 PITA;miRanda -0.173268305723103 8.01162282262283e-12 NA NA NA hsa-miR-335-5p LYPD3 -2.61355235628987 2.6462884165886e-51 1.45248580283244 1.87328918691671e-19 miRNAWalker2_validate -0.225005332501761 9.00303554153368e-14 NA NA NA hsa-miR-452-5p LYPD6 -2.48486455572568 1.24430987974325e-33 -0.911250846189553 0.000276581086647733 MirTarget -0.348098315464678 9.21763428330733e-19 NA NA NA hsa-miR-139-5p LYPLA1 -3.25846663863766 2.62018989415003e-112 0.774632698318401 1.02875497548964e-17 miRanda -0.152411394784354 3.06438079827982e-16 NA NA NA hsa-miR-145-5p LYPLA2 -2.62703571936687 7.64402900188551e-88 1.03867651066728 2.15051388059863e-42 miRNAWalker2_validate -0.194085545884774 5.6183448939167e-27 NA NA NA hsa-miR-21-5p LYRM7 2.32007501846389 3.08394781855554e-137 -0.831890142142728 4.40669022777023e-35 miRNAWalker2_validate -0.3290111222075 6.96813591950677e-59 NA NA NA hsa-miR-182-5p LYSMD4 2.36408084103818 2.60011457600281e-72 -0.805706057877902 4.74814482855276e-19 mirMAP -0.163821280809758 4.17053488648029e-14 NA NA NA hsa-miR-96-5p LYSMD4 3.24596558166606 1.92296159041707e-98 -0.805706057877902 4.74814482855276e-19 mirMAP -0.119093972687972 4.29673363188171e-11 NA NA NA hsa-miR-21-5p LZTFL1 2.32007501846389 3.08394781855554e-137 -0.175708040168738 0.0301015269402117 MirTarget -0.185515103257871 8.98140010710389e-14 NA NA NA hsa-miR-144-5p MACC1 -2.75914786146772 1.55794225315972e-50 0.116707433548087 0.474930831665486 mirMAP -0.165417663858283 4.56567530024181e-09 NA NA NA hsa-miR-139-5p MAD2L1 -3.25846663863766 2.62018989415003e-112 2.01579534776676 1.28950915382794e-54 miRanda -0.409478418276739 7.02082628030535e-53 NA NA NA hsa-miR-141-3p MAF 2.99777540204168 1.26370498493024e-78 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.280257139364435 1.13022065741888e-60 NA NA NA hsa-miR-182-5p MAF 2.36408084103818 2.60011457600281e-72 -1.16207333224511 7.05311108318644e-38 mirMAP;miRNATAP -0.309685327091339 4.1321653470338e-48 NA NA NA hsa-miR-200a-3p MAF 2.55218480823434 2.96135446816238e-51 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.238756255088114 2.38164269278218e-44 NA NA NA hsa-miR-200a-5p MAF 2.58844508672328 1.79650654234569e-56 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.25037391417016 1.07304378249966e-46 NA NA NA hsa-miR-200b-3p MAF 2.11744072703209 1.66710572104191e-43 -1.16207333224511 7.05311108318644e-38 TargetScan -0.269885334079408 6.2084548111735e-46 NA NA NA hsa-miR-200c-3p MAF 2.07038651806183 6.84613386286599e-51 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.318820975446133 8.73388346017541e-54 NA NA NA hsa-miR-429 MAF 2.84108892259147 3.88520896426515e-64 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.238854221843919 4.73960253039279e-45 NA NA NA hsa-miR-96-5p MAF 3.24596558166606 1.92296159041707e-98 -1.16207333224511 7.05311108318644e-38 TargetScan;miRNATAP -0.270250367160293 8.68817221040545e-54 NA NA NA hsa-miR-182-5p MAFB 2.36408084103818 2.60011457600281e-72 -0.102902384112692 0.258050638353509 mirMAP -0.12808353309313 2.45473440969175e-09 NA NA NA hsa-miR-429 MAFB 2.84108892259147 3.88520896426515e-64 -0.102902384112692 0.258050638353509 miRNATAP -0.129521370898772 2.19862587836682e-14 NA NA NA hsa-miR-96-5p MAFF 3.24596558166606 1.92296159041707e-98 -1.42080306664952 4.49221037689391e-33 MirTarget -0.232999882188311 1.23431022800875e-22 NA NA NA hsa-miR-182-5p MAFG 2.36408084103818 2.60011457600281e-72 -0.367617360654406 1.49249771524253e-07 mirMAP -0.135809041784426 1.66480520700608e-16 NA NA NA hsa-miR-139-5p MAGEC1 -3.25846663863766 2.62018989415003e-112 1.2221588080334 5.65957455239921e-06 miRanda -0.192659000574943 0.000538657852851188 NA NA NA hsa-miR-335-5p MAGED2 -2.61355235628987 2.6462884165886e-51 1.19499046724612 1.0583826308307e-21 miRNAWalker2_validate -0.117163767948651 7.52602917096408e-07 NA NA NA hsa-miR-139-5p MAGEF1 -3.25846663863766 2.62018989415003e-112 0.904671455925886 4.95180691754939e-35 miRanda -0.187064962981984 2.3185872952083e-35 NA NA NA hsa-miR-182-5p MAGEL2 2.36408084103818 2.60011457600281e-72 -0.283057253493267 0.102063497133644 miRNATAP -0.204471788198611 6.31712095636679e-07 NA NA NA hsa-miR-96-5p MAGEL2 3.24596558166606 1.92296159041707e-98 -0.283057253493267 0.102063497133644 TargetScan;miRNATAP -0.249778358447374 1.37823006598703e-13 NA NA NA hsa-miR-182-5p MAGI1 2.36408084103818 2.60011457600281e-72 -1.26305301454899 4.04392522280675e-34 miRNATAP -0.107005936563122 3.12217237798113e-05 NA NA NA hsa-miR-429 MAGI1 2.84108892259147 3.88520896426515e-64 -1.26305301454899 4.04392522280675e-34 miRanda;miRNATAP -0.139203045086852 6.18027094923475e-12 NA NA NA hsa-miR-96-5p MAGI1 3.24596558166606 1.92296159041707e-98 -1.26305301454899 4.04392522280675e-34 TargetScan;miRNATAP -0.166353997981752 2.64213541447949e-15 NA NA NA hsa-miR-141-3p MAGI2 2.99777540204168 1.26370498493024e-78 -0.936512824134223 3.7734967109359e-12 TargetScan;miRNATAP -0.151678725006706 8.72379088626456e-09 NA NA NA hsa-miR-200a-3p MAGI2 2.55218480823434 2.96135446816238e-51 -0.936512824134223 3.7734967109359e-12 miRNATAP -0.107014743228385 3.81979744809966e-05 NA NA NA hsa-miR-486-5p MAGIX -3.87258704301474 1.22658629378451e-80 1.45368341268656 5.55769198186677e-27 miRanda -0.14251306989715 1.09649865727141e-11 NA NA NA hsa-miR-145-5p MAGOHB -2.62703571936687 7.64402900188551e-88 0.776091825420421 1.34887280216577e-24 MirTarget -0.166654304795558 4.57860496605447e-21 NA NA NA hsa-miR-335-5p MAL2 -2.61355235628987 2.6462884165886e-51 1.46283694262068 7.6365311426135e-27 miRNAWalker2_validate -0.146571395243313 1.70607960581151e-08 NA NA NA hsa-miR-21-5p MALT1 2.32007501846389 3.08394781855554e-137 -0.460913474619447 2.90706556776411e-10 miRNAWalker2_validate -0.151618183797855 2.6958539808202e-11 NA NA NA hsa-miR-429 MAMDC2 2.84108892259147 3.88520896426515e-64 -3.79084223490056 3.12042470575769e-70 PITA;miRanda;miRNATAP -0.58030732413394 2.18671918749486e-43 NA NA NA hsa-miR-429 MAML2 2.84108892259147 3.88520896426515e-64 -2.51056466304563 1.96100954740259e-53 miRanda -0.33476356535698 1.81723186685135e-25 NA NA NA hsa-miR-429 MAMLD1 2.84108892259147 3.88520896426515e-64 -1.14792136798972 1.87438224248494e-17 miRanda -0.149366392638706 8.09871423962352e-09 NA NA NA hsa-miR-182-5p MAN1A1 2.36408084103818 2.60011457600281e-72 -1.14265977407889 2.91302048662424e-13 MirTarget -0.192217242753395 3.32404596210493e-07 NA NA NA hsa-miR-429 MAN2A1 2.84108892259147 3.88520896426515e-64 -0.500679339510088 0.00048074719389056 miRanda -0.171251322332088 2.17812532794698e-10 NA NA NA hsa-miR-182-5p MAP1A 2.36408084103818 2.60011457600281e-72 -0.89250845462883 6.21955962799672e-15 miRNATAP -0.217138354071102 1.70919481609401e-15 NA NA NA hsa-miR-141-3p MAP1B 2.99777540204168 1.26370498493024e-78 -1.55002312958356 5.26140421124211e-31 mirMAP -0.332839469538648 4.86786279869509e-38 NA NA NA hsa-miR-182-5p MAP1B 2.36408084103818 2.60011457600281e-72 -1.55002312958356 5.26140421124211e-31 MirTarget;mirMAP;miRNATAP -0.305231235378793 3.97023270087364e-21 NA NA NA hsa-miR-200a-3p MAP1B 2.55218480823434 2.96135446816238e-51 -1.55002312958356 5.26140421124211e-31 mirMAP -0.28658158412502 4.962612018885e-29 NA NA NA hsa-miR-200b-3p MAP1B 2.11744072703209 1.66710572104191e-43 -1.55002312958356 5.26140421124211e-31 TargetScan -0.320250401066909 2.60481652801636e-29 NA NA NA hsa-miR-429 MAP1B 2.84108892259147 3.88520896426515e-64 -1.55002312958356 5.26140421124211e-31 PITA;miRanda;miRNATAP -0.275952185425492 2.87514044347416e-27 NA NA NA hsa-miR-96-5p MAP1B 3.24596558166606 1.92296159041707e-98 -1.55002312958356 5.26140421124211e-31 TargetScan;miRNATAP -0.288595280166703 2.25659747615663e-27 NA NA NA hsa-miR-141-3p MAP2 2.99777540204168 1.26370498493024e-78 -1.48495084198261 2.62387512550646e-19 miRNATAP -0.176478146804683 6.58051204564353e-08 NA NA NA hsa-miR-200a-3p MAP2 2.55218480823434 2.96135446816238e-51 -1.48495084198261 2.62387512550646e-19 miRNATAP -0.117147634532134 0.000274750747600608 NA NA NA hsa-miR-200b-3p MAP2 2.11744072703209 1.66710572104191e-43 -1.48495084198261 2.62387512550646e-19 MirTarget;TargetScan -0.128113545004565 0.000348019982381255 NA NA NA hsa-miR-200c-3p MAP2 2.07038651806183 6.84613386286599e-51 -1.48495084198261 2.62387512550646e-19 MirTarget;miRNATAP -0.186944551452252 1.93599375569411e-06 NA NA NA hsa-miR-429 MAP2 2.84108892259147 3.88520896426515e-64 -1.48495084198261 2.62387512550646e-19 MirTarget;PITA;miRanda;miRNATAP -0.136473182466538 1.92350845429624e-05 NA NA NA hsa-miR-21-5p MAP3K2 2.32007501846389 3.08394781855554e-137 -0.231552627390085 0.0197411056315087 miRNAWalker2_validate;mirMAP -0.117694966119235 0.000139697716851587 NA NA NA hsa-miR-141-3p MAP3K3 2.99777540204168 1.26370498493024e-78 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.165901727144462 2.60406258844207e-47 NA NA NA hsa-miR-182-5p MAP3K3 2.36408084103818 2.60011457600281e-72 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.174662362093805 3.2021058811911e-34 NA NA NA hsa-miR-200a-3p MAP3K3 2.55218480823434 2.96135446816238e-51 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.135063200600891 7.18528329824784e-32 NA NA NA hsa-miR-429 MAP3K3 2.84108892259147 3.88520896426515e-64 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.134843971111218 3.2531482493031e-32 NA NA NA hsa-miR-96-5p MAP3K3 3.24596558166606 1.92296159041707e-98 -0.734541340963792 2.63872799634068e-34 MirTarget;TargetScan;miRNATAP -0.161945661566676 2.81030045385988e-43 NA NA NA hsa-miR-200b-3p MAP3K5 2.11744072703209 1.66710572104191e-43 -1.14088601125645 1.72781404202526e-25 TargetScan -0.203449016952416 4.00360408784291e-18 NA NA NA hsa-miR-429 MAP3K5 2.84108892259147 3.88520896426515e-64 -1.14088601125645 1.72781404202526e-25 PITA;miRanda;miRNATAP -0.186993561689497 3.71856058490676e-19 NA NA NA hsa-miR-103a-3p MAP3K7 0.610673390034345 1.63113920514646e-12 -0.143716552142434 0.0267403723117399 miRNAWalker2_validate -0.184281845409368 2.38036238656993e-13 NA NA NA hsa-miR-375 MAP3K8 2.09893673049766 1.68351780396203e-16 -1.2874759183903 1.74321074366661e-26 miRNAWalker2_validate -0.164213371246878 1.02420593264318e-24 NA NA NA hsa-miR-429 MAP3K8 2.84108892259147 3.88520896426515e-64 -1.2874759183903 1.74321074366661e-26 PITA;miRanda -0.164071361638277 2.14043089054769e-12 NA NA NA hsa-miR-144-5p MAP3K9 -2.75914786146772 1.55794225315972e-50 0.50088479523049 3.0542807284228e-05 mirMAP -0.110470964632615 1.23257163995621e-07 NA NA NA hsa-miR-378a-5p MAP3K9 -2.43173551693523 1.44932837789175e-68 0.50088479523049 3.0542807284228e-05 mirMAP -0.127150958475253 2.93042765444178e-06 NA NA NA hsa-miR-141-3p MAP4K4 2.99777540204168 1.26370498493024e-78 -0.308580581654411 0.00014813484298229 TargetScan -0.134453890562392 4.95116248896509e-18 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-182-5p MAP4K4 2.36408084103818 2.60011457600281e-72 -0.308580581654411 0.00014813484298229 MirTarget -0.147351716984953 1.33660645444299e-14 NA NA NA hsa-miR-200b-3p MAP4K4 2.11744072703209 1.66710572104191e-43 -0.308580581654411 0.00014813484298229 TargetScan -0.169304068185926 7.98066390013092e-24 NA NA NA hsa-miR-429 MAP4K4 2.84108892259147 3.88520896426515e-64 -0.308580581654411 0.00014813484298229 PITA;miRanda;miRNATAP -0.109688597683786 6.15288697896005e-13 NA NA NA hsa-miR-96-5p MAP4K4 3.24596558166606 1.92296159041707e-98 -0.308580581654411 0.00014813484298229 TargetScan -0.10479933354992 4.99971379946185e-11 NA NA NA hsa-miR-511-5p MAP7 -2.27545475897362 3.84085514050558e-36 0.942032423887889 7.94661641283741e-20 MirTarget -0.134653132847448 1.43199851401008e-12 NA NA NA hsa-miR-141-3p MAP7D1 2.99777540204168 1.26370498493024e-78 -0.244894483481591 0.000944722979969239 MirTarget;TargetScan;miRNATAP -0.118140486924444 6.88459313959795e-17 NA NA NA hsa-miR-183-5p MAP7D2 2.95681814393872 1.09965777344285e-92 -0.966075134071993 0.000130420806645832 miRNATAP -0.107026889378263 0.0453478073178185 NA NA NA hsa-miR-452-5p MAP9 -2.48486455572568 1.24430987974325e-33 -0.273810497567264 0.0628957261035456 mirMAP -0.115738215418284 7.68844395070897e-07 NA NA NA hsa-miR-130b-3p MAPK10 1.38122163823846 1.00932179737836e-26 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.311198542431805 1.15998229401123e-08 NA NA NA hsa-miR-146b-5p MAPK10 0.631041661167954 6.20366593452965e-08 -2.40438462003309 4.2516538591888e-32 miRanda -0.153060180737123 0.013695637696855 NA NA NA hsa-miR-19a-3p MAPK10 0.817507952171848 3.76285090469625e-08 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.222702615462015 4.17842244233184e-06 NA NA NA hsa-miR-19b-3p MAPK10 0.139124391010031 0.255658553872934 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.182028621380633 0.00223666160802019 NA NA NA hsa-miR-29b-3p MAPK10 0.438847962603729 6.46722433236121e-05 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.214951327451731 0.00114851870928561 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 1.32170168375632 2.12280368957514e-15 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.20354840914367 2.22032173676851e-06 NA NA NA hsa-miR-30d-3p MAPK10 0.264544633563642 0.00755023189129747 -2.40438462003309 4.2516538591888e-32 mirMAP -0.192664485965265 0.00899807954985931 NA NA NA hsa-miR-330-3p MAPK10 0.432728362037032 0.00041335506960812 -2.40438462003309 4.2516538591888e-32 PITA;miRNATAP -0.240537820613709 6.0605250152691e-05 NA NA NA hsa-miR-429 MAPK10 2.84108892259147 3.88520896426515e-64 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.366481358214565 1.02092652001284e-20 NA NA NA hsa-miR-454-3p MAPK10 1.28177672191095 6.84024979484587e-21 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.269274577449595 2.23366460726875e-07 NA NA NA hsa-miR-455-5p MAPK10 0.284641224662773 0.0357572339594277 -2.40438462003309 4.2516538591888e-32 miRanda -0.2052531701295 0.000129116493384105 NA NA NA hsa-miR-590-3p MAPK10 1.27438512890514 1.03164723481469e-23 -2.40438462003309 4.2516538591888e-32 miRanda;mirMAP -0.323164263319335 2.39879463887196e-08 NA NA NA hsa-miR-590-5p MAPK10 0.746515607868274 8.51300479640125e-09 -2.40438462003309 4.2516538591888e-32 PITA;miRanda;miRNATAP -0.208756960356003 0.000174508852265274 NA NA NA hsa-miR-335-5p MAPK13 -2.61355235628987 2.6462884165886e-51 1.49058465220791 9.34310856898705e-63 mirMAP -0.153169246178821 2.74313989203629e-18 NA NA NA hsa-miR-21-5p MAPK14 2.32007501846389 3.08394781855554e-137 -0.284160448012007 6.36269794096921e-09 mirMAP -0.113666961486213 5.43544541750221e-14 NA NA NA hsa-miR-183-5p MAPK4 2.95681814393872 1.09965777344285e-92 -3.00201377350489 2.00505525386542e-19 MirTarget -0.515718990328648 3.48650376175074e-13 NA NA NA hsa-miR-107 MAPK8 0.678998026350662 2.56224148930538e-16 -0.297398434625207 0.00492168724399827 miRNATAP -0.17791631045835 3.75913999690967e-05 NA NA NA hsa-miR-140-3p MAPK8 -1.25844395244141 5.29222651039892e-33 -0.297398434625207 0.00492168724399827 miRNAWalker2_validate -0.18488366577202 2.13922359684877e-08 NA NA NA hsa-miR-214-3p MAPK8 -0.523705501275844 0.000211299789901139 -0.297398434625207 0.00492168724399827 miRNAWalker2_validate -0.131663145030191 2.77448993612092e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.238328801322329 0.0377496760295305 -0.297398434625207 0.00492168724399827 mirMAP -0.111645018994966 0.000421521825972328 NA NA NA hsa-miR-361-5p MAPK8 -0.0996867547900457 0.095428250126326 -0.297398434625207 0.00492168724399827 PITA;miRanda;mirMAP -0.36263548128247 3.21553639920568e-09 NA NA NA hsa-miR-374a-3p MAPK8 0.34122393953022 2.28714105382856e-05 -0.297398434625207 0.00492168724399827 mirMAP -0.109853677099594 0.0151429921091769 NA NA NA hsa-miR-10b-5p MAPK8IP3 -2.10996264627796 7.36811595736367e-72 0.532750388429446 8.5941775911158e-07 mirMAP -0.124157461990045 1.76943842485894e-05 NA NA NA hsa-let-7i-5p MAPK9 -0.333419326258177 3.56960810786801e-08 0.291220683716117 6.17961998679004e-06 miRNATAP -0.306833929478603 2.50065627421339e-17 NA NA NA hsa-miR-20a-5p MAPK9 0.44979911120222 0.000602386964327228 0.291220683716117 6.17961998679004e-06 miRNAWalker2_validate;miRNATAP -0.149791797617831 1.16802726117118e-19 NA NA NA hsa-miR-361-5p MAPK9 -0.0996867547900457 0.095428250126326 0.291220683716117 6.17961998679004e-06 miRanda -0.302539307267532 3.19615101156316e-16 NA NA NA hsa-miR-374a-5p MAPK9 -0.239709888246804 0.00309819667153627 0.291220683716117 6.17961998679004e-06 mirMAP -0.208569547789819 1.38505915980085e-14 NA NA NA hsa-miR-374b-5p MAPK9 -0.466781429946153 1.17238311619116e-08 0.291220683716117 6.17961998679004e-06 mirMAP -0.162602292754305 1.32462729456077e-09 NA NA NA hsa-miR-92a-3p MAPK9 -0.342420481092807 0.000732275969501111 0.291220683716117 6.17961998679004e-06 miRNAWalker2_validate -0.159802962706798 1.32672396914361e-13 NA NA NA hsa-miR-141-3p MAPRE2 2.99777540204168 1.26370498493024e-78 -0.656745722938772 9.77547037861752e-13 TargetScan -0.126696815442538 1.51157144736313e-12 NA NA NA hsa-miR-10b-5p MARCH4 -2.10996264627796 7.36811595736367e-72 3.61531467471203 4.25513861559249e-52 mirMAP -0.830934769419202 1.03678119721233e-37 NA NA NA hsa-miR-200b-3p MARCH8 2.11744072703209 1.66710572104191e-43 -1.14430885937208 3.7997494940241e-16 MirTarget;TargetScan -0.150866268151388 5.89111869995042e-07 NA NA NA hsa-miR-200c-3p MARCH8 2.07038651806183 6.84613386286599e-51 -1.14430885937208 3.7997494940241e-16 MirTarget -0.155368237183204 2.96236320050355e-06 NA NA NA hsa-miR-429 MARCH8 2.84108892259147 3.88520896426515e-64 -1.14430885937208 3.7997494940241e-16 MirTarget -0.200960407189577 5.47197027228472e-14 NA NA NA hsa-miR-139-5p MARCKSL1 -3.25846663863766 2.62018989415003e-112 1.7392088520217 1.30413370724246e-72 miRanda -0.337319774698277 4.61140079824036e-63 NA NA NA hsa-miR-335-5p MARCKSL1 -2.61355235628987 2.6462884165886e-51 1.7392088520217 1.30413370724246e-72 miRNAWalker2_validate -0.19595823984911 1.02286316322824e-24 NA NA NA hsa-miR-141-3p MARK1 2.99777540204168 1.26370498493024e-78 -1.56660457597826 1.63468568431183e-20 TargetScan -0.25176806349255 2.93953065606926e-14 NA NA NA hsa-miR-429 MARK1 2.84108892259147 3.88520896426515e-64 -1.56660457597826 1.63468568431183e-20 miRanda -0.207028757380874 1.74284909304002e-10 NA NA NA hsa-miR-99a-5p MARK2 -2.25079447371102 1.14086813185885e-54 0.66251260638795 8.91612147809151e-27 miRNAWalker2_validate -0.109122113574423 4.18147965480815e-15 NA NA NA hsa-miR-335-5p MAST1 -2.61355235628987 2.6462884165886e-51 1.41453985457252 1.93369750992662e-09 miRNAWalker2_validate -0.164707234033753 0.000189911748864824 NA NA NA hsa-miR-429 MAST4 2.84108892259147 3.88520896426515e-64 -1.20416604293965 1.06755229706384e-12 miRanda;miRNATAP -0.230087513521466 7.2284497200809e-13 NA NA NA hsa-miR-139-5p MASTL -3.25846663863766 2.62018989415003e-112 0.534180842046073 1.76171118486199e-10 miRanda -0.137291145747566 1.07034985607732e-15 NA NA NA hsa-miR-21-5p MATN2 2.32007501846389 3.08394781855554e-137 -3.29740104225744 3.25541820206151e-67 miRNATAP -0.768197434664512 2.45662210651958e-35 NA NA NA hsa-miR-375 MATN2 2.09893673049766 1.68351780396203e-16 -3.29740104225744 3.25541820206151e-67 miRanda -0.227583597666673 2.21902441570678e-17 NA NA NA hsa-miR-21-5p MBLAC2 2.32007501846389 3.08394781855554e-137 -0.685157824318613 2.72296957151685e-15 MirTarget -0.30324709267087 2.58294121194424e-30 NA NA NA hsa-miR-141-3p MBNL1 2.99777540204168 1.26370498493024e-78 -1.03065753199503 1.22543346240534e-51 MirTarget;TargetScan;miRNATAP -0.175269017211848 1.09514095748495e-38 NA NA NA hsa-miR-183-5p MBNL1 2.95681814393872 1.09965777344285e-92 -1.03065753199503 1.22543346240534e-51 MirTarget;miRNATAP -0.193352871081257 3.82865131504741e-40 NA NA NA hsa-miR-200a-3p MBNL1 2.55218480823434 2.96135446816238e-51 -1.03065753199503 1.22543346240534e-51 MirTarget;miRNATAP -0.153315498753731 1.78628757092243e-30 NA NA NA hsa-miR-200a-5p MBNL1 2.58844508672328 1.79650654234569e-56 -1.03065753199503 1.22543346240534e-51 MirTarget -0.132218097389667 1.29515381300792e-21 NA NA NA hsa-miR-200b-3p MBNL1 2.11744072703209 1.66710572104191e-43 -1.03065753199503 1.22543346240534e-51 TargetScan -0.17491088267422 4.16579198660803e-32 NA NA NA hsa-miR-200c-3p MBNL1 2.07038651806183 6.84613386286599e-51 -1.03065753199503 1.22543346240534e-51 miRNATAP -0.204901368872066 1.2774301807245e-36 NA NA NA hsa-miR-21-5p MBNL1 2.32007501846389 3.08394781855554e-137 -1.03065753199503 1.22543346240534e-51 miRNAWalker2_validate;MirTarget;miRNATAP -0.270694729308032 9.41739086394107e-36 NA NA NA hsa-miR-429 MBNL1 2.84108892259147 3.88520896426515e-64 -1.03065753199503 1.22543346240534e-51 miRanda;miRNATAP -0.158828071684902 3.09043284790695e-33 NA NA NA hsa-miR-96-5p MBNL1 3.24596558166606 1.92296159041707e-98 -1.03065753199503 1.22543346240534e-51 TargetScan -0.196660478945009 8.78641345441955e-48 NA NA NA hsa-miR-182-5p MBNL2 2.36408084103818 2.60011457600281e-72 -1.37379574443944 8.08248700954969e-39 MirTarget;miRNATAP -0.201517733562762 8.15395350867999e-15 NA NA NA hsa-miR-200c-3p MBNL2 2.07038651806183 6.84613386286599e-51 -1.37379574443944 8.08248700954969e-39 miRNATAP -0.222396480040019 1.38680969745804e-18 NA NA NA hsa-miR-429 MBNL2 2.84108892259147 3.88520896426515e-64 -1.37379574443944 8.08248700954969e-39 miRanda;miRNATAP -0.186443497042984 9.24952122795791e-20 NA NA NA hsa-miR-96-5p MBNL2 3.24596558166606 1.92296159041707e-98 -1.37379574443944 8.08248700954969e-39 TargetScan;miRNATAP -0.19397959479075 1.23125618104002e-19 NA NA NA hsa-miR-141-3p MBNL3 2.99777540204168 1.26370498493024e-78 -1.92990157111799 7.13881373145437e-25 MirTarget;TargetScan;miRNATAP -0.327014549420147 5.90250368501858e-19 NA NA NA hsa-miR-200a-3p MBNL3 2.55218480823434 2.96135446816238e-51 -1.92990157111799 7.13881373145437e-25 MirTarget;miRNATAP -0.294548796335619 4.13743425781522e-16 NA NA NA hsa-miR-200a-5p MBNL3 2.58844508672328 1.79650654234569e-56 -1.92990157111799 7.13881373145437e-25 mirMAP -0.193131868767282 2.62990680368254e-07 NA NA NA hsa-miR-200b-3p MBNL3 2.11744072703209 1.66710572104191e-43 -1.92990157111799 7.13881373145437e-25 MirTarget;TargetScan -0.319731542353063 2.16635878136419e-15 NA NA NA hsa-miR-200c-3p MBNL3 2.07038651806183 6.84613386286599e-51 -1.92990157111799 7.13881373145437e-25 MirTarget;mirMAP -0.347391597010734 4.75813168464757e-15 NA NA NA hsa-miR-21-3p MBNL3 2.17476065946878 5.15299442583591e-75 -1.92990157111799 7.13881373145437e-25 MirTarget -0.198379918802418 9.22291605949604e-05 NA NA NA hsa-miR-21-5p MBNL3 2.32007501846389 3.08394781855554e-137 -1.92990157111799 7.13881373145437e-25 MirTarget;mirMAP -0.505555147963686 1.12505269243851e-17 NA NA NA hsa-miR-375 MBNL3 2.09893673049766 1.68351780396203e-16 -1.92990157111799 7.13881373145437e-25 miRNATAP -0.18148196637137 5.2939444227262e-13 NA NA NA hsa-miR-429 MBNL3 2.84108892259147 3.88520896426515e-64 -1.92990157111799 7.13881373145437e-25 MirTarget;mirMAP;miRNATAP -0.297929299644788 1.12772918355858e-16 NA NA NA hsa-miR-452-5p MBOAT2 -2.48486455572568 1.24430987974325e-33 1.34520703521989 5.13463397254214e-29 MirTarget -0.10783559337144 5.09054216500219e-08 NA NA NA hsa-miR-141-3p MBP 2.99777540204168 1.26370498493024e-78 -1.05743986242831 1.70792931878289e-20 mirMAP -0.125591567342395 2.50155581738413e-08 NA NA NA hsa-miR-21-5p MBP 2.32007501846389 3.08394781855554e-137 -1.05743986242831 1.70792931878289e-20 mirMAP -0.307335685655512 7.08494398545229e-18 NA NA NA hsa-miR-96-5p MBP 3.24596558166606 1.92296159041707e-98 -1.05743986242831 1.70792931878289e-20 mirMAP -0.195860811155093 4.89930267760185e-18 NA NA NA hsa-miR-429 MCAM 2.84108892259147 3.88520896426515e-64 -1.89903035331471 8.2726468734385e-71 miRNATAP -0.298206377720762 3.002253342619e-46 NA NA NA hsa-miR-200a-5p MCC 2.58844508672328 1.79650654234569e-56 -1.14440901729692 6.9012862547581e-21 MirTarget -0.152414512334114 3.04022017633601e-10 NA NA NA hsa-miR-200b-3p MCC 2.11744072703209 1.66710572104191e-43 -1.14440901729692 6.9012862547581e-21 TargetScan -0.177840933340175 1.22599606768502e-11 NA NA NA hsa-miR-21-5p MCC 2.32007501846389 3.08394781855554e-137 -1.14440901729692 6.9012862547581e-21 mirMAP -0.323331426882474 2.97240228120409e-17 NA NA NA hsa-miR-429 MCC 2.84108892259147 3.88520896426515e-64 -1.14440901729692 6.9012862547581e-21 PITA;miRanda;miRNATAP -0.199575476365417 8.96833940507288e-18 NA NA NA hsa-miR-486-5p MCCC2 -3.87258704301474 1.22658629378451e-80 0.537480329764514 1.07466414426391e-05 miRanda -0.101532760420672 4.15789636496101e-08 NA NA NA hsa-miR-200b-3p MCFD2 2.11744072703209 1.66710572104191e-43 -0.543306041289844 1.28010442553734e-20 MirTarget;TargetScan -0.109470392395964 1.0353815636115e-18 NA NA NA hsa-miR-200c-3p MCFD2 2.07038651806183 6.84613386286599e-51 -0.543306041289844 1.28010442553734e-20 MirTarget -0.103018000699861 5.90812546517832e-14 NA NA NA hsa-miR-139-5p MCM2 -3.25846663863766 2.62018989415003e-112 1.73269377201954 5.84458756938441e-53 miRanda -0.379699354760018 7.55666672084272e-61 NA NA NA hsa-miR-486-5p MCM4 -3.87258704301474 1.22658629378451e-80 1.45760657687267 7.97875515771763e-35 miRanda -0.152023951412333 1.71953741553817e-16 NA NA NA hsa-miR-99a-5p MCM8 -2.25079447371102 1.14086813185885e-54 0.329805054197105 0.000388037257384159 miRNAWalker2_validate -0.112326906458574 4.25628529284824e-08 NA NA NA hsa-miR-141-3p MCOLN3 2.99777540204168 1.26370498493024e-78 -1.28921105052088 2.09632759584398e-11 MirTarget;TargetScan -0.163664882541194 1.45877992335885e-05 NA NA NA hsa-miR-200a-3p MCOLN3 2.55218480823434 2.96135446816238e-51 -1.28921105052088 2.09632759584398e-11 MirTarget -0.201531738530857 4.80797859507484e-08 NA NA NA hsa-miR-141-5p MCTP1 2.38411349683216 4.56310582620282e-58 -1.60151272020006 4.27309943958378e-26 MirTarget;miRNATAP -0.292806692578082 5.66493503330726e-19 NA NA NA hsa-miR-182-5p MCTP2 2.36408084103818 2.60011457600281e-72 -1.62726166944733 1.93244599734137e-19 miRNATAP -0.442800579776868 3.77906840171338e-25 NA NA NA hsa-miR-96-5p MCTP2 3.24596558166606 1.92296159041707e-98 -1.62726166944733 1.93244599734137e-19 TargetScan;miRNATAP -0.36109428912802 2.69137624209966e-24 NA NA NA hsa-miR-429 MDFIC 2.84108892259147 3.88520896426515e-64 -1.28696470408277 5.63155231412861e-42 miRanda;miRNATAP -0.253676245754637 1.12419556633931e-45 NA NA NA hsa-miR-141-3p MDGA1 2.99777540204168 1.26370498493024e-78 -0.0639263710072093 0.639909371226836 TargetScan;miRNATAP -0.193416619747444 1.47399458931137e-13 NA NA NA hsa-miR-200a-3p MDGA1 2.55218480823434 2.96135446816238e-51 -0.0639263710072093 0.639909371226836 miRNATAP -0.144693783337777 2.19166116828042e-08 NA NA NA hsa-miR-378a-5p MDGA1 -2.43173551693523 1.44932837789175e-68 -0.0639263710072093 0.639909371226836 mirMAP -0.130879867596143 2.16460714003448e-05 NA NA NA hsa-miR-429 MDGA1 2.84108892259147 3.88520896426515e-64 -0.0639263710072093 0.639909371226836 miRNATAP -0.128968821643319 5.35692508401932e-07 NA NA NA hsa-miR-10b-5p MDGA2 -2.10996264627796 7.36811595736367e-72 -0.343323084924894 0.199326841381384 MirTarget;miRNATAP -0.320359692763567 6.45177964366646e-06 NA NA NA hsa-miR-375 MDGA2 2.09893673049766 1.68351780396203e-16 -0.343323084924894 0.199326841381384 miRanda -0.210140933488348 1.8917655333525e-09 NA NA NA hsa-miR-182-5p MECOM 2.36408084103818 2.60011457600281e-72 -1.48814463240513 9.33988431556657e-35 miRNATAP -0.228573197826528 1.25524077795686e-14 NA NA NA hsa-miR-429 MECOM 2.84108892259147 3.88520896426515e-64 -1.48814463240513 9.33988431556657e-35 miRNATAP -0.302140148835841 3.92499795236488e-40 NA NA NA hsa-miR-96-5p MECOM 3.24596558166606 1.92296159041707e-98 -1.48814463240513 9.33988431556657e-35 TargetScan;miRNATAP -0.257792863093034 1.8194242358337e-26 NA NA NA hsa-miR-21-3p MECP2 2.17476065946878 5.15299442583591e-75 -0.461019995437165 5.63618149586866e-20 mirMAP -0.130373196457547 4.49603362022048e-23 NA NA NA hsa-miR-21-5p MECP2 2.32007501846389 3.08394781855554e-137 -0.461019995437165 5.63618149586866e-20 mirMAP -0.143762623869606 4.46382340722961e-20 NA NA NA hsa-miR-139-5p MED14 -3.25846663863766 2.62018989415003e-112 0.30756193891303 6.48328898458939e-06 miRanda -0.102483420057256 1.6279285944542e-13 NA NA NA hsa-miR-378a-5p MED29 -2.43173551693523 1.44932837789175e-68 0.407823011340064 6.51199119798712e-14 mirMAP -0.138737645156571 8.43231878737604e-31 NA NA NA hsa-miR-21-5p MEF2A 2.32007501846389 3.08394781855554e-137 -0.716196369219254 1.90630305209111e-19 miRNAWalker2_validate -0.239314536269004 2.95303977244974e-22 NA NA NA hsa-miR-182-5p MEF2C 2.36408084103818 2.60011457600281e-72 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.300723563792995 4.32642954345554e-39 NA NA NA hsa-miR-183-5p MEF2C 2.95681814393872 1.09965777344285e-92 -1.3628193091141 3.63471865869307e-46 MirTarget;miRNATAP -0.304597174462637 1.85002963697187e-52 NA NA NA hsa-miR-21-5p MEF2C 2.32007501846389 3.08394781855554e-137 -1.3628193091141 3.63471865869307e-46 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.349922334680877 1.22856305351208e-30 NA NA NA hsa-miR-429 MEF2C 2.84108892259147 3.88520896426515e-64 -1.3628193091141 3.63471865869307e-46 miRanda;miRNATAP -0.268097792284511 4.40553586167332e-50 NA NA NA hsa-miR-96-5p MEF2C 3.24596558166606 1.92296159041707e-98 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.28116413771846 1.32376660175131e-50 NA NA NA hsa-miR-144-5p MEGF10 -2.75914786146772 1.55794225315972e-50 -0.928654842849274 6.40616707690104e-05 MirTarget -0.101856560695017 0.0122401194562999 NA NA NA hsa-miR-429 MEGF10 2.84108892259147 3.88520896426515e-64 -0.928654842849274 6.40616707690104e-05 MirTarget;PITA -0.133198570238837 0.00256337114824469 NA NA NA hsa-miR-21-5p MEGF9 2.32007501846389 3.08394781855554e-137 -0.296058092250146 0.0106105936693003 miRNAWalker2_validate;mirMAP;miRNATAP -0.149252740775158 3.45279684976026e-05 NA NA NA hsa-miR-21-5p MEIS1 2.32007501846389 3.08394781855554e-137 -1.15665155808698 2.45274500904609e-26 miRNAWalker2_validate -0.188974454034122 5.73560587743375e-08 NA NA NA hsa-miR-429 MEIS1 2.84108892259147 3.88520896426515e-64 -1.15665155808698 2.45274500904609e-26 miRanda;miRNATAP -0.191539316505006 3.61577115610229e-20 NA NA NA hsa-miR-141-3p MEIS2 2.99777540204168 1.26370498493024e-78 -1.95002058092382 8.956929391428e-51 TargetScan -0.363924271571133 2.56704000410149e-46 NA NA NA hsa-miR-429 MEIS2 2.84108892259147 3.88520896426515e-64 -1.95002058092382 8.956929391428e-51 miRNATAP -0.317792639128373 1.20104829558786e-36 NA NA NA hsa-miR-335-5p MEIS3 -2.61355235628987 2.6462884165886e-51 0.930290969797346 2.23725670159486e-09 miRNAWalker2_validate -0.112919349501545 0.000105480406589437 NA NA NA hsa-miR-429 MEOX2 2.84108892259147 3.88520896426515e-64 -3.39102506471798 5.89655061796805e-62 miRanda;miRNATAP -0.539542969732687 5.51232589170445e-42 NA NA NA hsa-miR-429 MEST 2.84108892259147 3.88520896426515e-64 -1.87820766081128 3.91503997331289e-33 miRanda;miRNATAP -0.269458655818472 5.4521430595406e-19 NA NA NA hsa-miR-139-3p METTL2A -3.44089023199323 1.67292890850702e-91 0.515099973635595 6.51379774341864e-14 MirTarget -0.109304325790781 6.74228113125562e-19 NA NA NA hsa-miR-429 METTL7A 2.84108892259147 3.88520896426515e-64 -1.94794260010446 2.06317009120139e-77 miRanda -0.250930207782303 6.62374084889454e-33 NA NA NA hsa-miR-139-5p MEX3A -3.25846663863766 2.62018989415003e-112 1.86654686669598 1.43925910579182e-25 PITA;miRanda;miRNATAP -0.460447433361081 6.35809387748255e-37 NA NA NA hsa-miR-182-5p MFAP3L 2.36408084103818 2.60011457600281e-72 -0.596269094340481 7.72914739798849e-05 miRNATAP -0.206652890047592 7.88537223191392e-09 NA NA NA hsa-miR-200a-3p MFAP3L 2.55218480823434 2.96135446816238e-51 -0.596269094340481 7.72914739798849e-05 MirTarget -0.116652654374201 5.12290232089732e-05 NA NA NA hsa-miR-96-5p MFAP3L 3.24596558166606 1.92296159041707e-98 -0.596269094340481 7.72914739798849e-05 MirTarget;miRNATAP -0.155364506590922 1.79286192384576e-07 NA NA NA hsa-miR-200b-3p MFAP5 2.11744072703209 1.66710572104191e-43 -1.7372996699481 1.15820603382006e-18 TargetScan -0.416640331285456 1.23444205417206e-23 NA NA NA hsa-miR-200c-3p MFAP5 2.07038651806183 6.84613386286599e-51 -1.7372996699481 1.15820603382006e-18 miRNATAP -0.504700300707793 1.08619258765981e-28 NA NA NA hsa-miR-429 MFAP5 2.84108892259147 3.88520896426515e-64 -1.7372996699481 1.15820603382006e-18 miRanda;miRNATAP -0.362088653325579 2.10248513316363e-22 NA NA NA hsa-miR-200b-3p MFHAS1 2.11744072703209 1.66710572104191e-43 -0.23084721682902 0.0617583813746145 TargetScan -0.115117033872735 1.04754818783411e-05 NA NA NA hsa-miR-96-5p MFHAS1 3.24596558166606 1.92296159041707e-98 -0.23084721682902 0.0617583813746145 TargetScan;miRNATAP -0.105201808894029 1.56074176824952e-05 NA NA NA hsa-miR-335-5p MFSD6L -2.61355235628987 2.6462884165886e-51 0.827354108152797 0.00129574561728746 miRNAWalker2_validate -0.154861078890733 0.00121313509760147 NA NA NA hsa-miR-21-5p MGA 2.32007501846389 3.08394781855554e-137 -0.465870611745895 8.08061890696543e-09 miRNAWalker2_validate -0.163741978014178 7.09173890086628e-11 NA NA NA hsa-miR-200c-3p MGAT3 2.07038651806183 6.84613386286599e-51 -1.9246123472567 1.2847337143263e-31 miRNATAP -0.352188306418152 1.89315166994181e-19 NA NA NA hsa-miR-429 MGAT3 2.84108892259147 3.88520896426515e-64 -1.9246123472567 1.2847337143263e-31 miRanda;miRNATAP -0.262870867846316 1.47805772631506e-16 NA NA NA hsa-miR-145-5p MGAT4A -2.62703571936687 7.64402900188551e-88 0.493804333900288 3.29725111038758e-05 mirMAP -0.109434679951773 7.6673486251121e-05 NA NA NA hsa-miR-452-5p MGAT4A -2.48486455572568 1.24430987974325e-33 0.493804333900288 3.29725111038758e-05 mirMAP -0.18202418558363 1.26197952585819e-22 NA NA NA hsa-miR-141-3p MGAT5 2.99777540204168 1.26370498493024e-78 -0.845793008139424 7.3367191920958e-06 TargetScan;mirMAP -0.159081686829536 1.49245463471532e-05 NA NA NA hsa-miR-182-5p MGAT5 2.36408084103818 2.60011457600281e-72 -0.845793008139424 7.3367191920958e-06 mirMAP -0.13265967228646 0.00331719087102893 NA NA NA hsa-miR-200a-3p MGAT5 2.55218480823434 2.96135446816238e-51 -0.845793008139424 7.3367191920958e-06 mirMAP -0.16067184550895 8.24099718241873e-06 NA NA NA hsa-miR-96-5p MGAT5 3.24596558166606 1.92296159041707e-98 -0.845793008139424 7.3367191920958e-06 TargetScan -0.168322397120745 6.5962717756911e-06 NA NA NA hsa-miR-10b-5p MGRN1 -2.10996264627796 7.36811595736367e-72 0.852709057677421 4.07699097399489e-43 mirMAP -0.125934599128112 2.1176046167864e-13 NA NA NA hsa-miR-139-5p MGRN1 -3.25846663863766 2.62018989415003e-112 0.852709057677421 4.07699097399489e-43 miRanda -0.127951923952621 1.45920425137188e-22 NA NA NA hsa-miR-96-5p MGST1 3.24596558166606 1.92296159041707e-98 -1.21871033305175 7.49923603343964e-12 miRNAWalker2_validate -0.104339706398294 0.0034162667026881 NA NA NA hsa-miR-21-5p MIB1 2.32007501846389 3.08394781855554e-137 -0.227708764488398 0.00438270014454061 miRNAWalker2_validate;mirMAP -0.133079244800936 7.70648522942277e-08 NA NA NA hsa-miR-335-5p MIB2 -2.61355235628987 2.6462884165886e-51 0.266330853908843 0.0400273217025228 miRNAWalker2_validate -0.134349330303126 1.97719188817921e-08 NA NA NA hsa-miR-183-5p MICA 2.95681814393872 1.09965777344285e-92 -0.210908695551431 0.0165086604618095 MirTarget -0.10148840342213 3.56079748609633e-08 NA NA NA hsa-miR-139-5p MICAL2 -3.25846663863766 2.62018989415003e-112 1.40135482253089 1.84788264984717e-38 miRanda -0.241522207685426 1.26727599896264e-26 NA NA NA hsa-miR-141-3p MICAL3 2.99777540204168 1.26370498493024e-78 -0.95590506366019 6.06115901437355e-27 mirMAP -0.110292938795541 4.51096898205879e-10 NA NA NA hsa-miR-141-5p MICAL3 2.38411349683216 4.56310582620282e-58 -0.95590506366019 6.06115901437355e-27 mirMAP -0.111997604881047 1.06311456573109e-08 NA NA NA hsa-miR-200a-3p MICAL3 2.55218480823434 2.96135446816238e-51 -0.95590506366019 6.06115901437355e-27 mirMAP -0.106757529539423 7.76119124383125e-10 NA NA NA hsa-miR-375 MICAL3 2.09893673049766 1.68351780396203e-16 -0.95590506366019 6.06115901437355e-27 miRanda -0.118006907235479 1.37244335048099e-23 NA NA NA hsa-miR-429 MID1 2.84108892259147 3.88520896426515e-64 -2.12501225256922 1.36617450025625e-34 miRanda -0.237323987728705 2.33053737923583e-12 NA NA NA hsa-miR-429 MID2 2.84108892259147 3.88520896426515e-64 -0.799925928617615 7.05192180338706e-20 miRanda -0.128672633681393 1.44194074344197e-14 NA NA NA hsa-miR-452-5p MIER3 -2.48486455572568 1.24430987974325e-33 -0.156765043501904 0.0447344262426408 mirMAP -0.101600596666067 1.08490381436567e-16 NA NA NA hsa-miR-451a MIF -3.06435303493596 1.30560050967986e-53 2.12804906419844 6.69990056367891e-54 miRNAWalker2_validate;miRTarBase -0.155819471490055 3.22502874927481e-11 26161389;27612504 The expression of miR-451a and the target gene macrophage migration inhibitory factor MIF were detected by real-time reverse transcriptase polymerase chain reaction and/or western blot; Overexpression of miR-451a downregulated MIF expression in mRNA and protein levels and inhibited cell proliferation colony formation and invasion of breast cancer cells; Downregulation of miR-451a upregulated MIF expression and increased breast cancer cell growth invasion and tamoxifen sensitivity;Expression pattern of miR 451 and its target MIF macrophage migration inhibitory factor in colorectal cancer; To investigate the expression pattern of microRNA-451 miR-451 in patients with colorectal carcinoma and correlate with the expression of its target gene MIF macrophage migration inhibitory factor; In addition paraffin blocks of 10 colorectal carcinomas with lowest expression of miR-451 were used for the study of MIF protein expression by immunohistochemistry; Majority of the cases 80% with low expression of miR-451 showed high levels of MIF protein expression confirming the inverse relationship between miR-451 and MIF expressions; The results showed that miR-451 could play a role in development and progression of colorectal cancer and likely by targeting MIF ;progression breast cancer;colorectal cancer hsa-miR-452-5p MIPOL1 -2.48486455572568 1.24430987974325e-33 0.357116995366797 0.00180032704342608 mirMAP -0.206221989309795 1.40431576801944e-31 NA NA NA hsa-miR-182-5p MITF 2.36408084103818 2.60011457600281e-72 -1.35051354106808 1.10754633569261e-32 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.290712861931307 1.61027808146775e-26 19188590 In human tissues expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels progression melanoma hsa-miR-200c-3p MITF 2.07038651806183 6.84613386286599e-51 -1.35051354106808 1.10754633569261e-32 miRNATAP -0.382284463696344 3.10046832412687e-49 NA NA NA hsa-miR-429 MITF 2.84108892259147 3.88520896426515e-64 -1.35051354106808 1.10754633569261e-32 miRNATAP -0.268693273872433 4.00236849955712e-36 NA NA NA hsa-miR-96-5p MITF 3.24596558166606 1.92296159041707e-98 -1.35051354106808 1.10754633569261e-32 miRTarBase;TargetScan;miRNATAP -0.297823124424408 5.16568525694953e-41 NA NA NA hsa-miR-21-5p MKNK2 2.32007501846389 3.08394781855554e-137 0.0137795715779827 0.872309059382961 miRNAWalker2_validate -0.112053298236543 2.51599581837069e-05 NA NA NA hsa-miR-21-3p MLC1 2.17476065946878 5.15299442583591e-75 -0.00602240290377876 0.981829799025522 MirTarget -0.198525241891628 0.00431893490976159 NA NA NA hsa-miR-21-5p MLH3 2.32007501846389 3.08394781855554e-137 -0.240810871770317 9.49770080000442e-06 mirMAP -0.107851819719156 1.41645141081624e-10 NA NA NA hsa-miR-486-5p MLLT11 -3.87258704301474 1.22658629378451e-80 1.35269539788608 4.65030972716515e-29 miRanda -0.146729131706109 4.76235822086233e-15 NA NA NA hsa-miR-452-5p MLLT3 -2.48486455572568 1.24430987974325e-33 -0.378104133164759 0.00143669597198025 mirMAP -0.104494797816157 3.04444681789214e-08 NA NA NA hsa-miR-182-5p MMD 2.36408084103818 2.60011457600281e-72 -2.29894276851442 1.03228947173554e-69 miRNATAP -0.458928493542741 1.30019499597675e-46 NA NA NA hsa-miR-200b-3p MMD 2.11744072703209 1.66710572104191e-43 -2.29894276851442 1.03228947173554e-69 TargetScan -0.462073269053207 2.32292736704446e-61 NA NA NA hsa-miR-200c-3p MMD 2.07038651806183 6.84613386286599e-51 -2.29894276851442 1.03228947173554e-69 miRNATAP -0.503467849869215 4.38383159952573e-60 NA NA NA hsa-miR-375 MMD 2.09893673049766 1.68351780396203e-16 -2.29894276851442 1.03228947173554e-69 miRanda;miRNATAP -0.158611813569505 6.69752073427209e-18 NA NA NA hsa-miR-429 MMD 2.84108892259147 3.88520896426515e-64 -2.29894276851442 1.03228947173554e-69 PITA;miRanda;miRNATAP -0.379640549127169 7.1107634935895e-51 NA NA NA hsa-miR-429 MME 2.84108892259147 3.88520896426515e-64 -4.18607277920172 1.04864183760856e-76 miRanda -0.616588808767003 3.03295491941195e-43 NA NA NA hsa-miR-335-5p MMEL1 -2.61355235628987 2.6462884165886e-51 1.12563509203929 7.78304788534882e-07 miRNAWalker2_validate -0.10211073209675 0.016605302252194 NA NA NA hsa-miR-200b-3p MMGT1 2.11744072703209 1.66710572104191e-43 -0.617659717682437 3.70461431852723e-20 MirTarget -0.10615928976706 1.47047707755359e-13 NA NA NA hsa-miR-145-5p MMP1 -2.62703571936687 7.64402900188551e-88 6.06794406171332 1.97080965138208e-60 miRNAWalker2_validate -0.776560200165228 1.4991690670364e-17 NA NA NA hsa-miR-145-5p MMP12 -2.62703571936687 7.64402900188551e-88 1.47938135981664 1.47098262596235e-05 miRNAWalker2_validate -0.192036777823138 0.0160531504579215 NA NA NA hsa-miR-145-5p MMP14 -2.62703571936687 7.64402900188551e-88 1.17709675366481 4.88698053995378e-22 miRNAWalker2_validate -0.100472607295886 0.00054272881478419 NA NA NA hsa-miR-335-5p MMP14 -2.61355235628987 2.6462884165886e-51 1.17709675366481 4.88698053995378e-22 miRNAWalker2_validate -0.209036899933566 3.86604363416133e-20 NA NA NA hsa-miR-141-3p MMP16 2.99777540204168 1.26370498493024e-78 -0.481934192325192 0.0113040399956389 TargetScan -0.293734231626602 7.14719307279982e-16 NA NA NA hsa-miR-141-5p MMP16 2.38411349683216 4.56310582620282e-58 -0.481934192325192 0.0113040399956389 mirMAP -0.16821062644559 3.73807757827437e-05 NA NA NA hsa-miR-200a-5p MMP16 2.58844508672328 1.79650654234569e-56 -0.481934192325192 0.0113040399956389 mirMAP -0.157209618900798 2.24638425618584e-05 NA NA NA hsa-miR-200b-3p MMP16 2.11744072703209 1.66710572104191e-43 -0.481934192325192 0.0113040399956389 TargetScan -0.271198441852451 1.13277150858291e-11 NA NA NA hsa-miR-429 MMP16 2.84108892259147 3.88520896426515e-64 -0.481934192325192 0.0113040399956389 PITA;miRanda;miRNATAP -0.265297626032991 8.81275885544332e-14 NA NA NA hsa-miR-429 MMP19 2.84108892259147 3.88520896426515e-64 -0.723233476523302 1.96955818136923e-16 miRanda;miRNATAP -0.162713497253888 7.06444437015845e-23 NA NA NA hsa-miR-139-5p MMP8 -3.25846663863766 2.62018989415003e-112 0.721432106241961 0.00818680598047258 miRanda -0.11164763253484 0.0474091434021207 NA NA NA hsa-miR-451a MMP9 -3.06435303493596 1.30560050967986e-53 2.99738222256974 1.90567455663357e-33 miRNAWalker2_validate;miRTarBase -0.121709149808104 0.00355918876588089 NA NA NA hsa-miR-21-3p MMRN2 2.17476065946878 5.15299442583591e-75 -1.94920145520552 1.4683568625424e-67 MirTarget -0.434974291318957 1.80328343906633e-46 NA NA NA hsa-miR-141-3p MN1 2.99777540204168 1.26370498493024e-78 -0.459509646859896 0.00118312104981719 TargetScan -0.304352355434743 3.01070746708641e-30 NA NA NA hsa-miR-139-5p MNX1 -3.25846663863766 2.62018989415003e-112 2.38520649514388 1.40430733405966e-13 miRanda -0.409092132000863 9.34694092624785e-10 NA NA NA hsa-miR-21-5p MOAP1 2.32007501846389 3.08394781855554e-137 -0.0885110850384718 0.215376940800626 miRNAWalker2_validate -0.158290848322491 5.34122665491176e-13 NA NA NA hsa-miR-200b-3p MOCS1 2.11744072703209 1.66710572104191e-43 -1.97216951564682 5.39670718242351e-81 TargetScan -0.309009734903682 1.06314108116799e-40 NA NA NA hsa-miR-429 MOCS1 2.84108892259147 3.88520896426515e-64 -1.97216951564682 5.39670718242351e-81 miRanda;miRNATAP -0.305045932322184 1.36572638807473e-50 NA NA NA hsa-miR-21-5p MON2 2.32007501846389 3.08394781855554e-137 -0.531742758397095 8.92863225323636e-16 miRNAWalker2_validate;MirTarget;mirMAP -0.202563569965516 3.09016059395836e-23 NA NA NA hsa-miR-21-5p MORC3 2.32007501846389 3.08394781855554e-137 -0.574933255007071 3.98078485469327e-17 miRNAWalker2_validate -0.212646055021811 6.9942586544642e-24 NA NA NA hsa-miR-452-5p MORN4 -2.48486455572568 1.24430987974325e-33 0.0646009762371564 0.445811499022342 MirTarget -0.152926482067414 6.94626846438024e-32 NA NA NA hsa-miR-486-5p MOXD1 -3.87258704301474 1.22658629378451e-80 0.847981196948034 4.00797050083991e-07 miRanda -0.113689209753978 8.24411814510891e-06 NA NA NA hsa-miR-200b-3p MPDZ 2.11744072703209 1.66710572104191e-43 -1.4560885223525 1.43773083617831e-46 MirTarget -0.226725321198426 1.79436119144364e-24 NA NA NA hsa-miR-200c-3p MPDZ 2.07038651806183 6.84613386286599e-51 -1.4560885223525 1.43773083617831e-46 MirTarget -0.253733095771084 2.41521592177249e-25 NA NA NA hsa-miR-429 MPDZ 2.84108892259147 3.88520896426515e-64 -1.4560885223525 1.43773083617831e-46 MirTarget;miRanda -0.22509942969955 2.66626883688263e-30 NA NA NA hsa-miR-210-3p MPEG1 2.38367203491819 3.73261999106754e-22 -0.859677732587716 2.49375726197081e-11 MirTarget -0.11269878841612 1.11835511397964e-10 NA NA NA hsa-miR-335-5p MPND -2.61355235628987 2.6462884165886e-51 0.693007046385506 3.36021564430224e-14 miRNAWalker2_validate -0.104646446929884 9.10050467482749e-10 NA NA NA hsa-miR-182-5p MPP1 2.36408084103818 2.60011457600281e-72 -0.505421126688657 1.3704451904162e-09 miRNATAP -0.230322030579118 6.84257075774077e-33 NA NA NA hsa-miR-96-5p MPP1 3.24596558166606 1.92296159041707e-98 -0.505421126688657 1.3704451904162e-09 TargetScan;miRNATAP -0.1701223354018 5.8193527087439e-26 NA NA NA hsa-miR-21-5p MPP5 2.32007501846389 3.08394781855554e-137 -0.461905356415691 2.1822279898673e-09 miRNAWalker2_validate -0.237239157137834 9.36639981799512e-24 NA NA NA hsa-miR-141-3p MPPED2 2.99777540204168 1.26370498493024e-78 -1.92995077631031 1.27147853851054e-23 TargetScan -0.294365915993185 8.68483398384101e-15 NA NA NA hsa-miR-429 MPPED2 2.84108892259147 3.88520896426515e-64 -1.92995077631031 1.27147853851054e-23 miRanda;miRNATAP -0.235293725499125 2.51863452508244e-10 NA NA NA hsa-miR-141-3p MPRIP 2.99777540204168 1.26370498493024e-78 -0.644300216328719 4.0274408922109e-28 TargetScan -0.161832374420818 2.64483974336262e-48 NA NA NA hsa-miR-200b-3p MPRIP 2.11744072703209 1.66710572104191e-43 -0.644300216328719 4.0274408922109e-28 MirTarget;TargetScan -0.133799171371761 5.2915762214808e-27 NA NA NA hsa-miR-200c-3p MPRIP 2.07038651806183 6.84613386286599e-51 -0.644300216328719 4.0274408922109e-28 MirTarget;miRNATAP -0.187194770996915 1.34654418726286e-44 NA NA NA hsa-miR-21-3p MPRIP 2.17476065946878 5.15299442583591e-75 -0.644300216328719 4.0274408922109e-28 MirTarget -0.147053401062455 3.17842484629864e-21 NA NA NA hsa-miR-21-5p MPRIP 2.32007501846389 3.08394781855554e-137 -0.644300216328719 4.0274408922109e-28 miRNATAP -0.157771533487089 1.49778101287334e-17 NA NA NA hsa-miR-429 MPRIP 2.84108892259147 3.88520896426515e-64 -0.644300216328719 4.0274408922109e-28 MirTarget;miRanda;miRNATAP -0.105859662428078 3.03520905749248e-21 NA NA NA hsa-miR-378a-5p MR1 -2.43173551693523 1.44932837789175e-68 0.327436070496887 0.000151124551464722 miRNATAP -0.123620676216979 1.95918844115945e-10 NA NA NA hsa-miR-21-5p MRAP2 2.32007501846389 3.08394781855554e-137 -2.06418061734632 9.05954455513086e-20 miRNAWalker2_validate -0.370285682421531 2.70370460520469e-07 NA NA NA hsa-miR-182-5p MRAS 2.36408084103818 2.60011457600281e-72 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.524902959445825 1.41898946761564e-64 NA NA NA hsa-miR-429 MRAS 2.84108892259147 3.88520896426515e-64 -2.33160876190743 5.5050134478505e-74 miRanda;miRNATAP -0.296364992468048 8.90534224451228e-31 NA NA NA hsa-miR-96-5p MRAS 3.24596558166606 1.92296159041707e-98 -2.33160876190743 5.5050134478505e-74 TargetScan;miRNATAP -0.416938612016912 1.97469399011339e-58 NA NA NA hsa-miR-139-5p MRPL42 -3.25846663863766 2.62018989415003e-112 0.64749623648039 1.03149585972226e-25 MirTarget;miRanda -0.158255583145433 1.32876828941107e-36 NA NA NA hsa-miR-139-5p MRPL48 -3.25846663863766 2.62018989415003e-112 0.472872312128549 5.94511001661759e-11 miRanda -0.131064221512681 5.19800820700141e-19 NA NA NA hsa-miR-452-5p MRPS23 -2.48486455572568 1.24430987974325e-33 0.932998574039517 9.49444827282929e-32 MirTarget -0.103001810578998 2.2958680320753e-15 NA NA NA hsa-miR-99a-5p MRPS33 -2.25079447371102 1.14086813185885e-54 0.35063646120893 4.50921889397608e-07 miRNAWalker2_validate -0.145061201729946 7.00002655123885e-22 NA NA NA hsa-miR-141-5p MRVI1 2.38411349683216 4.56310582620282e-58 -1.28848982300958 1.34334434965756e-30 MirTarget -0.28380889682877 3.66879956237241e-32 NA NA NA hsa-miR-183-5p MRVI1 2.95681814393872 1.09965777344285e-92 -1.28848982300958 1.34334434965756e-30 miRNATAP -0.279525210300483 2.07070819607016e-32 NA NA NA hsa-miR-200b-3p MRVI1 2.11744072703209 1.66710572104191e-43 -1.28848982300958 1.34334434965756e-30 MirTarget -0.292914570668046 3.09474793701166e-35 NA NA NA hsa-miR-200c-3p MRVI1 2.07038651806183 6.84613386286599e-51 -1.28848982300958 1.34334434965756e-30 MirTarget -0.34784748675264 1.89463452245531e-41 NA NA NA hsa-miR-429 MRVI1 2.84108892259147 3.88520896426515e-64 -1.28848982300958 1.34334434965756e-30 MirTarget;miRanda;miRNATAP -0.280057506350519 1.07152114934395e-40 NA NA NA hsa-miR-429 MS4A2 2.84108892259147 3.88520896426515e-64 -0.791944427086409 0.00109280176197654 miRanda -0.417518784104647 1.75115250798216e-20 NA NA NA hsa-miR-139-5p MSH2 -3.25846663863766 2.62018989415003e-112 0.401162339853424 1.5451989731878e-07 miRanda -0.136386453002367 1.46725203876399e-18 NA NA NA hsa-miR-139-3p MSI1 -3.44089023199323 1.67292890850702e-91 0.320688602085372 0.212184441621039 PITA -0.124096568781687 0.00745977985727426 NA NA NA hsa-miR-224-5p MSI2 -2.22249420723892 1.07787949391113e-18 0.930531374382857 4.33351530355709e-16 mirMAP -0.163080644048041 1.73072951171833e-27 NA NA NA hsa-miR-335-5p MSLN -2.61355235628987 2.6462884165886e-51 0.860638966297784 0.0332232664001507 miRNAWalker2_validate -0.380271967627019 3.63130739505661e-07 NA NA NA hsa-miR-182-5p MSN 2.36408084103818 2.60011457600281e-72 -0.578039968356322 4.29885633617379e-10 MirTarget -0.243269424100621 1.20244071363692e-29 NA NA NA hsa-miR-200b-3p MSN 2.11744072703209 1.66710572104191e-43 -0.578039968356322 4.29885633617379e-10 MirTarget;TargetScan -0.168931968633106 3.68772184314926e-18 24037528 MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways; Instead we found that miR-200b repressed several actin-associated genes with the knockdown of the ezrin-radixin-moesin family member moesin alone phenocopying the repression of cell invasion by miR-200b; Moesin was verified to be directly targeted by miR-200b and restoration of moesin in miR-200b-expressing cells was sufficient to alleviate metastatic repression; In breast cancer cell lines and patient samples the expression of moesin significantly inversely correlated with miR-200 expression and high levels of moesin were associated with poor relapse-free survival metastasis;poor survival breast cancer hsa-miR-200c-3p MSN 2.07038651806183 6.84613386286599e-51 -0.578039968356322 4.29885633617379e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.193434786532672 1.25331591841618e-19 NA NA NA hsa-miR-429 MSN 2.84108892259147 3.88520896426515e-64 -0.578039968356322 4.29885633617379e-10 MirTarget;PITA;miRanda;miRNATAP -0.12137431840363 4.07465396141331e-12 NA NA NA hsa-miR-96-5p MSN 3.24596558166606 1.92296159041707e-98 -0.578039968356322 4.29885633617379e-10 MirTarget;TargetScan;miRNATAP -0.169716097795413 5.49159830237017e-21 NA NA NA hsa-miR-200b-3p MSRB3 2.11744072703209 1.66710572104191e-43 -2.04546871502378 2.21436286434622e-54 mirMAP -0.41551256735815 2.79065379396152e-49 NA NA NA hsa-miR-200c-3p MSRB3 2.07038651806183 6.84613386286599e-51 -2.04546871502378 2.21436286434622e-54 mirMAP -0.514534020899057 2.09845636418037e-64 NA NA NA hsa-miR-429 MSRB3 2.84108892259147 3.88520896426515e-64 -2.04546871502378 2.21436286434622e-54 mirMAP -0.387949361908277 2.11420960690786e-54 NA NA NA hsa-miR-200a-5p MSTN 2.58844508672328 1.79650654234569e-56 -1.95071701732345 9.7288278082099e-23 MirTarget -0.281860863744207 8.34347702210391e-13 NA NA NA hsa-miR-429 MSTN 2.84108892259147 3.88520896426515e-64 -1.95071701732345 9.7288278082099e-23 miRanda -0.250964542225675 5.63579881476371e-11 NA NA NA hsa-miR-10b-5p MSTO1 -2.10996264627796 7.36811595736367e-72 0.394689423042844 2.09532969006739e-10 miRNAWalker2_validate -0.146823368604382 2.65304247255893e-19 NA NA NA hsa-miR-21-5p MSX1 2.32007501846389 3.08394781855554e-137 -0.862768844272717 2.12249217087809e-12 miRNATAP -0.103509234308864 0.00763262040296447 NA NA NA hsa-miR-96-5p MT1E 3.24596558166606 1.92296159041707e-98 -0.854938218622982 1.5662585799435e-06 TargetScan -0.139679467838922 7.69004202113168e-05 NA NA NA hsa-miR-21-5p MTAP 2.32007501846389 3.08394781855554e-137 -0.205567553133638 0.017351504048108 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111192139316398 3.46052582192821e-05 NA NA NA hsa-miR-139-5p MTBP -3.25846663863766 2.62018989415003e-112 0.812569639582878 3.98700075805872e-12 miRanda -0.21965410623744 3.66317253143916e-20 NA NA NA hsa-miR-139-3p MTDH -3.44089023199323 1.67292890850702e-91 0.347649808246738 3.74448593999784e-06 miRNAWalker2_validate -0.10995433344318 2.06976687449732e-16 NA NA NA hsa-miR-429 MTMR10 2.84108892259147 3.88520896426515e-64 -1.08673232492879 1.93663995526401e-55 miRanda;miRNATAP -0.15822437614143 1.45211150685708e-31 NA NA NA hsa-miR-21-5p MTMR12 2.32007501846389 3.08394781855554e-137 -0.63972249267847 7.45127244761851e-18 miRNAWalker2_validate;miRNATAP -0.24346929793164 2.16450805709664e-26 NA NA NA hsa-miR-21-5p MTMR3 2.32007501846389 3.08394781855554e-137 -0.566292607621955 1.56044811090748e-20 mirMAP -0.19915851983753 4.20986539364831e-26 NA NA NA hsa-miR-21-5p MTMR9 2.32007501846389 3.08394781855554e-137 -0.632252261815016 1.3345727353147e-18 miRNAWalker2_validate -0.209927277063899 5.02692538949849e-21 NA NA NA hsa-miR-429 MTMR9 2.84108892259147 3.88520896426515e-64 -0.632252261815016 1.3345727353147e-18 miRanda;miRNATAP -0.137137732132559 3.07189210064034e-24 NA NA NA hsa-miR-21-5p MTR 2.32007501846389 3.08394781855554e-137 -0.325593624816287 1.0711590931283e-06 mirMAP -0.125547989511482 1.35618621235181e-09 NA NA NA hsa-miR-10b-5p MTSS1L -2.10996264627796 7.36811595736367e-72 0.116953746654834 0.255698565259695 miRNATAP -0.168255836074964 5.72128510948162e-10 NA NA NA hsa-miR-183-5p MTUS1 2.95681814393872 1.09965777344285e-92 -0.903333305111318 7.6977763693091e-17 miRNAWalker2_validate -0.155682192971847 1.34929922901615e-11 27155522 Also among MTUS1 targeting miRNAs miR-183-5p was identified to be overexpressed in breast cancer and down-regulated in fibroadenoma tissues; Also expression levels of MTUS1 and miR-183-5p were well correlated with clinical parameters; In particular MTUS1 expression was found to be diminished and miR-183-5p expression was elevated with the advancing stage; In conclusion as a potential therapeutic target miR-183-5p can be a chief regulator of MTUS1 and MTUS1-miR-183-5p axis may have significant influence in the pathology of breast cancer staging breast cancer hsa-miR-200c-3p MTUS1 2.07038651806183 6.84613386286599e-51 -0.903333305111318 7.6977763693091e-17 miRNATAP -0.152390042094713 2.46939519817383e-09 NA NA NA hsa-miR-429 MTUS1 2.84108892259147 3.88520896426515e-64 -0.903333305111318 7.6977763693091e-17 miRanda;miRNATAP -0.161248262922381 4.90126382669544e-15 NA NA NA hsa-miR-145-5p MUC1 -2.62703571936687 7.64402900188551e-88 2.6031293995538 1.72038877386261e-27 miRNAWalker2_validate;miRTarBase -0.381041291185968 2.23197939904781e-11 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-335-5p MUC1 -2.61355235628987 2.6462884165886e-51 2.6031293995538 1.72038877386261e-27 miRNAWalker2_validate -0.327070840237111 6.22613212261101e-13 NA NA NA hsa-miR-335-5p MUC13 -2.61355235628987 2.6462884165886e-51 0.61391550799408 0.0466753765223715 MirTarget -0.144385249373363 0.0118807858727177 NA NA NA hsa-miR-183-5p MUC15 2.95681814393872 1.09965777344285e-92 -3.21987405974139 1.03371381531784e-15 miRNATAP -0.406587104624665 2.13628299529864e-06 NA NA NA hsa-miR-375 MUC15 2.09893673049766 1.68351780396203e-16 -3.21987405974139 1.03371381531784e-15 MirTarget;miRanda -0.334495109211679 3.80448822962048e-10 NA NA NA hsa-miR-183-5p MUC20 2.95681814393872 1.09965777344285e-92 -0.190612714917295 0.340034727083898 mirMAP -0.104288921126793 0.0132545212589459 NA NA NA hsa-miR-335-5p MUC5B -2.61355235628987 2.6462884165886e-51 0.928686812946105 0.022654364246835 miRNAWalker2_validate -0.207311350512125 0.00622566533804545 NA NA NA hsa-miR-139-5p MXD3 -3.25846663863766 2.62018989415003e-112 1.47874396259176 8.13529330676008e-40 miRanda -0.246183024560041 1.15825467975465e-25 NA NA NA hsa-miR-486-5p MXD3 -3.87258704301474 1.22658629378451e-80 1.47874396259176 8.13529330676008e-40 miRanda -0.128280060487283 3.51521554859824e-13 NA NA NA hsa-miR-200b-3p MXI1 2.11744072703209 1.66710572104191e-43 -1.09569304324504 4.15005057850764e-34 TargetScan -0.108579957214413 3.94030003344781e-08 NA NA NA hsa-miR-429 MXI1 2.84108892259147 3.88520896426515e-64 -1.09569304324504 4.15005057850764e-34 miRNATAP -0.12290485611418 2.51919090967237e-12 NA NA NA hsa-miR-139-5p MXRA5 -3.25846663863766 2.62018989415003e-112 0.858602981221213 1.15597151175191e-09 miRanda -0.16134676472261 3.0596149295001e-08 NA NA NA hsa-miR-429 MXRA7 2.84108892259147 3.88520896426515e-64 -1.09511385005226 1.64723765843341e-32 miRNATAP -0.210632766901572 1.63196947730544e-33 NA NA NA hsa-miR-182-5p MYADM 2.36408084103818 2.60011457600281e-72 -0.976381468148222 5.12624595262159e-29 miRNATAP -0.153824458867969 4.7069613286586e-13 NA NA NA hsa-miR-429 MYADM 2.84108892259147 3.88520896426515e-64 -0.976381468148222 5.12624595262159e-29 miRNATAP -0.165527256138033 3.24252437298597e-23 NA NA NA hsa-miR-96-5p MYADM 3.24596558166606 1.92296159041707e-98 -0.976381468148222 5.12624595262159e-29 TargetScan;miRNATAP -0.174453522663409 1.16029603329707e-23 NA NA NA hsa-miR-139-5p MYB -3.25846663863766 2.62018989415003e-112 1.3385004671291 4.8746375657764e-10 miRanda -0.201268900654479 6.36833621426088e-06 NA NA NA hsa-miR-10b-5p MYBL1 -2.10996264627796 7.36811595736367e-72 1.42535592912356 5.42533909728815e-16 miRNATAP -0.366234735215015 6.80533848155396e-15 NA NA NA hsa-miR-139-5p MYBL1 -3.25846663863766 2.62018989415003e-112 1.42535592912356 5.42533909728815e-16 PITA;miRanda;miRNATAP -0.294503420982815 4.66518502027834e-16 NA NA NA hsa-miR-21-5p MYC 2.32007501846389 3.08394781855554e-137 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.84108892259147 3.88520896426515e-64 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-139-5p MYCBP -3.25846663863766 2.62018989415003e-112 0.700834645803064 5.99010482890695e-28 MirTarget;miRanda -0.135286895268835 1.34373286890947e-24 NA NA NA hsa-miR-511-5p MYCBP -2.27545475897362 3.84085514050558e-36 0.700834645803064 5.99010482890695e-28 MirTarget -0.101012540758024 1.0836703101503e-17 NA NA NA hsa-miR-183-5p MYCBP2 2.95681814393872 1.09965777344285e-92 -1.39018088172622 2.08433767236495e-40 miRNAWalker2_validate -0.231167900514346 8.85236090970121e-25 NA NA NA hsa-miR-21-5p MYCBP2 2.32007501846389 3.08394781855554e-137 -1.39018088172622 2.08433767236495e-40 miRNAWalker2_validate -0.379537407508662 1.36415926000751e-30 NA NA NA hsa-miR-139-5p MYCN -3.25846663863766 2.62018989415003e-112 0.780687675113636 0.000394444208292669 miRanda -0.149987957438608 0.000966156441714079 NA NA NA hsa-miR-429 MYCT1 2.84108892259147 3.88520896426515e-64 -2.0771636415503 8.89274277517341e-73 miRanda -0.36684299652999 1.13976251512432e-61 NA NA NA hsa-miR-139-5p MYEF2 -3.25846663863766 2.62018989415003e-112 0.553427331133231 2.34778821065553e-05 miRanda -0.101833186300819 0.000162493391621293 NA NA NA hsa-miR-511-5p MYEF2 -2.27545475897362 3.84085514050558e-36 0.553427331133231 2.34778821065553e-05 MirTarget -0.137663789033459 6.72672911745338e-09 NA NA NA hsa-miR-429 MYEOV 2.84108892259147 3.88520896426515e-64 -3.05937775231631 1.05734107731273e-27 miRanda -0.32231778549674 3.41199705473699e-09 NA NA NA hsa-miR-141-3p MYH10 2.99777540204168 1.26370498493024e-78 -0.758370724363282 8.91647543769729e-19 TargetScan;miRNATAP -0.168957276481543 1.73018252591467e-24 NA NA NA hsa-miR-200a-3p MYH10 2.55218480823434 2.96135446816238e-51 -0.758370724363282 8.91647543769729e-19 miRNATAP -0.148172420907332 1.17786148310824e-19 NA NA NA hsa-miR-200b-3p MYLK 2.11744072703209 1.66710572104191e-43 -2.468210552686 9.30073457733719e-63 TargetScan -0.309913441680872 8.09237031263242e-21 NA NA NA hsa-miR-429 MYLK 2.84108892259147 3.88520896426515e-64 -2.468210552686 9.30073457733719e-63 PITA;miRanda;miRNATAP -0.336023519715106 1.14874203218121e-30 NA NA NA hsa-miR-486-5p MYLK2 -3.87258704301474 1.22658629378451e-80 2.44698988720978 5.06470112437287e-36 MirTarget;PITA;miRanda;miRNATAP -0.207509445441808 1.35828448402989e-11 NA NA NA hsa-miR-182-5p MYLK4 2.36408084103818 2.60011457600281e-72 -1.32633852079998 5.44221624183428e-27 mirMAP -0.23281415370841 6.70055528542405e-15 NA NA NA hsa-miR-375 MYO16 2.09893673049766 1.68351780396203e-16 -2.34133577954585 2.69114939800743e-28 miRanda -0.149229357803358 2.24861624890983e-07 NA NA NA hsa-miR-96-5p MYO16 3.24596558166606 1.92296159041707e-98 -2.34133577954585 2.69114939800743e-28 TargetScan -0.417661195355652 5.73350149128672e-23 NA NA NA hsa-miR-429 MYO1C 2.84108892259147 3.88520896426515e-64 -0.628568393377139 2.05112382087202e-19 miRNATAP -0.116704609026952 1.08353544102745e-18 NA NA NA hsa-miR-182-5p MYO1E 2.36408084103818 2.60011457600281e-72 -0.0538003742950295 0.503642283176377 mirMAP -0.129126284748718 8.69042238044777e-12 NA NA NA hsa-miR-429 MYO3A 2.84108892259147 3.88520896426515e-64 -0.806465216368001 0.00146457454444527 miRanda -0.160887822360237 0.000818813820190779 NA NA NA hsa-miR-139-5p MYO3B -3.25846663863766 2.62018989415003e-112 0.610933457520906 0.0420953868923393 miRanda -0.135300816483338 0.0290194594487221 NA NA NA hsa-miR-335-5p MYO3B -2.61355235628987 2.6462884165886e-51 0.610933457520906 0.0420953868923393 miRNAWalker2_validate -0.124397917258463 0.0261184936085446 NA NA NA hsa-miR-486-5p MYO3B -3.87258704301474 1.22658629378451e-80 0.610933457520906 0.0420953868923393 miRanda -0.194155223243538 2.02538119696192e-05 NA NA NA hsa-miR-141-3p MYO5A 2.99777540204168 1.26370498493024e-78 -0.398919677130254 2.00854123129672e-06 TargetScan -0.102524688816236 2.73472289781491e-10 NA NA NA hsa-miR-200b-3p MYO5A 2.11744072703209 1.66710572104191e-43 -0.398919677130254 2.00854123129672e-06 mirMAP -0.10348783881442 5.55036219904604e-09 NA NA NA hsa-miR-200c-3p MYO5A 2.07038651806183 6.84613386286599e-51 -0.398919677130254 2.00854123129672e-06 mirMAP -0.117857746896427 1.52096258652778e-09 NA NA NA hsa-miR-144-5p MYO5B -2.75914786146772 1.55794225315972e-50 0.961015485520267 2.7067218595287e-15 mirMAP -0.163122301738924 1.54251726383443e-14 NA NA NA hsa-miR-145-5p MYO6 -2.62703571936687 7.64402900188551e-88 0.64462966298129 1.058698364996e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116693579773699 5.6139791172851e-07 20353999 A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer prostate cancer hsa-miR-141-3p MYO9A 2.99777540204168 1.26370498493024e-78 -1.40955646491574 1.09089456601387e-22 TargetScan -0.232727140523994 1.61261894664566e-16 NA NA NA hsa-miR-200b-3p MYO9A 2.11744072703209 1.66710572104191e-43 -1.40955646491574 1.09089456601387e-22 TargetScan -0.204673996961689 4.11267655935714e-11 NA NA NA hsa-miR-21-5p MYO9A 2.32007501846389 3.08394781855554e-137 -1.40955646491574 1.09089456601387e-22 miRNAWalker2_validate -0.444675828361764 3.57171081828398e-23 NA NA NA hsa-miR-429 MYO9A 2.84108892259147 3.88520896426515e-64 -1.40955646491574 1.09089456601387e-22 miRanda -0.21026067559554 2.43514162220154e-14 NA NA NA hsa-miR-96-5p MYO9A 3.24596558166606 1.92296159041707e-98 -1.40955646491574 1.09089456601387e-22 TargetScan -0.243974451372789 1.70942738089429e-17 NA NA NA hsa-miR-141-5p MYOCD 2.38411349683216 4.56310582620282e-58 -3.20912330320665 5.01639511243565e-50 mirMAP -0.589905626892089 1.02909744896933e-35 NA NA NA hsa-miR-182-5p MYOCD 2.36408084103818 2.60011457600281e-72 -3.20912330320665 5.01639511243565e-50 miRNATAP -0.427955001838491 2.00659665491644e-15 NA NA NA hsa-miR-96-5p MYOCD 3.24596558166606 1.92296159041707e-98 -3.20912330320665 5.01639511243565e-50 MirTarget -0.534535019833899 1.48392072001583e-34 NA NA NA hsa-miR-200b-3p MYPN 2.11744072703209 1.66710572104191e-43 -0.379441699415515 0.177285983027929 TargetScan -0.240031659737225 5.48868276948628e-05 NA NA NA hsa-miR-141-3p MYRIP 2.99777540204168 1.26370498493024e-78 -2.17370145905386 1.8691130119275e-20 MirTarget;TargetScan -0.447914278860007 7.45923333091757e-23 NA NA NA hsa-miR-200a-3p MYRIP 2.55218480823434 2.96135446816238e-51 -2.17370145905386 1.8691130119275e-20 MirTarget -0.332385253579732 1.96060370821431e-13 NA NA NA hsa-miR-429 MYRIP 2.84108892259147 3.88520896426515e-64 -2.17370145905386 1.8691130119275e-20 miRNATAP -0.371474174158238 9.67311042992912e-17 NA NA NA hsa-miR-96-5p MYRIP 3.24596558166606 1.92296159041707e-98 -2.17370145905386 1.8691130119275e-20 MirTarget;TargetScan -0.315121249906902 2.01448490939929e-11 NA NA NA hsa-miR-452-5p MZF1 -2.48486455572568 1.24430987974325e-33 0.400101881546914 0.000178471178163654 MirTarget -0.155934029830045 1.07577058643123e-20 NA NA NA hsa-miR-200b-3p N4BP2 2.11744072703209 1.66710572104191e-43 -0.756054494854111 3.74801492146601e-06 TargetScan -0.127770906231228 0.000241836548169462 NA NA NA hsa-miR-429 N4BP2 2.84108892259147 3.88520896426515e-64 -0.756054494854111 3.74801492146601e-06 miRNATAP -0.149083954824446 1.5085280561881e-06 NA NA NA hsa-miR-21-5p N4BP2L1 2.32007501846389 3.08394781855554e-137 -1.51521720590613 3.96227189132689e-51 MirTarget -0.443625464430723 1.64635801690063e-44 NA NA NA hsa-miR-10b-5p N4BP3 -2.10996264627796 7.36811595736367e-72 1.7378506508527 1.46780112018656e-37 mirMAP -0.249747290331787 2.67594962686371e-11 NA NA NA hsa-miR-335-5p N4BP3 -2.61355235628987 2.6462884165886e-51 1.7378506508527 1.46780112018656e-37 mirMAP -0.229847026515245 6.30351177066924e-19 NA NA NA hsa-miR-378a-5p N4BP3 -2.43173551693523 1.44932837789175e-68 1.7378506508527 1.46780112018656e-37 mirMAP -0.466873760073938 2.78596970593624e-54 NA NA NA hsa-miR-21-5p NAA30 2.32007501846389 3.08394781855554e-137 -0.313537324419509 3.24121168615301e-07 miRNAWalker2_validate;MirTarget -0.174052804733812 1.89838019591547e-20 NA NA NA hsa-miR-429 NAALAD2 2.84108892259147 3.88520896426515e-64 -3.25764299818245 3.21590398840408e-108 miRanda -0.461789056633096 1.19211796879586e-53 NA NA NA hsa-miR-200b-3p NAB1 2.11744072703209 1.66710572104191e-43 -1.06240474610946 1.78235336600763e-35 MirTarget;TargetScan -0.1283812049395 6.82435465444992e-12 NA NA NA hsa-miR-200c-3p NAB1 2.07038651806183 6.84613386286599e-51 -1.06240474610946 1.78235336600763e-35 MirTarget;miRNATAP -0.160505669558308 4.74227689000818e-15 NA NA NA hsa-miR-429 NAB1 2.84108892259147 3.88520896426515e-64 -1.06240474610946 1.78235336600763e-35 MirTarget;PITA;miRanda;miRNATAP -0.12289137440458 1.69692885434716e-13 NA NA NA hsa-miR-10b-5p NACC1 -2.10996264627796 7.36811595736367e-72 1.51552796491601 2.11586911493332e-89 miRNATAP -0.337168105506637 3.30235538158316e-58 NA NA NA hsa-miR-141-5p NACC2 2.38411349683216 4.56310582620282e-58 -0.262380715567463 0.00802340344710353 mirMAP -0.121419477537221 8.83608486206813e-09 NA NA NA hsa-miR-200b-3p NALCN 2.11744072703209 1.66710572104191e-43 -1.41930195137925 1.65240218006176e-12 MirTarget -0.154340387081952 0.000350214007141606 NA NA NA hsa-miR-200c-3p NALCN 2.07038651806183 6.84613386286599e-51 -1.41930195137925 1.65240218006176e-12 MirTarget -0.19472505977526 4.01388029363856e-05 NA NA NA hsa-miR-429 NALCN 2.84108892259147 3.88520896426515e-64 -1.41930195137925 1.65240218006176e-12 MirTarget;miRanda -0.213395377788996 2.61987783526733e-08 NA NA NA hsa-miR-429 NAP1L2 2.84108892259147 3.88520896426515e-64 -2.3966072689926 6.13134138241339e-30 PITA;miRanda -0.375875655046841 1.68547830910713e-20 NA NA NA hsa-miR-429 NAP1L3 2.84108892259147 3.88520896426515e-64 -0.949549746357651 8.26084586229749e-14 miRanda;miRNATAP -0.247647186728115 1.85668431738571e-25 NA NA NA hsa-miR-200b-3p NAP1L5 2.11744072703209 1.66710572104191e-43 -1.09993598867014 5.12983053371275e-25 MirTarget -0.10270428763052 9.46391566799738e-06 NA NA NA hsa-miR-200c-3p NAP1L5 2.07038651806183 6.84613386286599e-51 -1.09993598867014 5.12983053371275e-25 MirTarget;miRNATAP -0.176603895915331 2.83800688791621e-12 NA NA NA hsa-miR-21-3p NAP1L5 2.17476065946878 5.15299442583591e-75 -1.09993598867014 5.12983053371275e-25 MirTarget -0.285919795055424 2.37414748297127e-24 NA NA NA hsa-miR-429 NAP1L5 2.84108892259147 3.88520896426515e-64 -1.09993598867014 5.12983053371275e-25 MirTarget;PITA;miRanda;miRNATAP -0.133146711690273 9.64746518169884e-11 NA NA NA hsa-miR-183-5p NAT8L 2.95681814393872 1.09965777344285e-92 -2.93784052922262 7.82426389917244e-41 mirMAP -0.497855155968735 5.94348162366967e-26 NA NA NA hsa-miR-96-5p NAT8L 3.24596558166606 1.92296159041707e-98 -2.93784052922262 7.82426389917244e-41 TargetScan -0.492380059659431 7.26378209067877e-29 NA NA NA hsa-miR-429 NAV1 2.84108892259147 3.88520896426515e-64 -0.159057359476455 0.12674105203339 miRNATAP -0.122681570043284 3.36128388134694e-10 NA NA NA hsa-miR-429 NAV2 2.84108892259147 3.88520896426515e-64 -1.59412053952078 7.0768020326804e-26 miRNATAP -0.156042901944032 1.16232778983179e-07 NA NA NA hsa-miR-141-3p NAV3 2.99777540204168 1.26370498493024e-78 -1.78347027501907 7.45924181306669e-19 mirMAP -0.375856079138767 5.47467915471397e-22 NA NA NA hsa-miR-200a-3p NAV3 2.55218480823434 2.96135446816238e-51 -1.78347027501907 7.45924181306669e-19 mirMAP -0.286122528392311 1.40165004590312e-13 NA NA NA hsa-miR-21-3p NAV3 2.17476065946878 5.15299442583591e-75 -1.78347027501907 7.45924181306669e-19 MirTarget -0.517799257774435 9.6690213330049e-23 25579119 We identify NAV3 as a potential target of miR-21-3p and show that knockdown of NAV3 increases resistance; Finally we use publically available transcriptomic data to demonstrate that miR-21-3p is raised while NAV3 is reduced in ovarian tumours that are resistant to platinum treatment; Our data suggest that miR-21-3p can induce cisplatin resistance in ovarian tumours potentially by targeting the NAV3 gene drug resistance ovarian cancer hsa-miR-429 NAV3 2.84108892259147 3.88520896426515e-64 -1.78347027501907 7.45924181306669e-19 PITA;miRanda -0.358345681713078 4.52010231538842e-21 NA NA NA hsa-miR-96-5p NAV3 3.24596558166606 1.92296159041707e-98 -1.78347027501907 7.45924181306669e-19 TargetScan -0.251620787434952 4.23272949195377e-10 NA NA NA hsa-miR-21-5p NBEA 2.32007501846389 3.08394781855554e-137 -0.839776830944797 1.66396522124089e-06 miRNAWalker2_validate;miRNATAP -0.33294742747243 9.96623739729255e-10 NA NA NA hsa-miR-429 NBEA 2.84108892259147 3.88520896426515e-64 -0.839776830944797 1.66396522124089e-06 miRNATAP -0.209993381127072 2.19641842134645e-10 NA NA NA hsa-miR-429 NBEAL1 2.84108892259147 3.88520896426515e-64 -1.49005960591897 1.71865407568919e-17 miRanda -0.251578403910066 4.65862782716932e-14 NA NA NA hsa-miR-141-3p NBPF14 2.99777540204168 1.26370498493024e-78 -0.767813346588161 6.20641831716256e-09 MirTarget -0.101885875248119 8.12590685240456e-05 NA NA NA hsa-miR-182-5p NCALD 2.36408084103818 2.60011457600281e-72 -2.05695176070075 2.17540632610368e-39 miRNATAP -0.393414615703445 5.24035932414122e-25 NA NA NA hsa-miR-96-5p NCALD 3.24596558166606 1.92296159041707e-98 -2.05695176070075 2.17540632610368e-39 TargetScan;miRNATAP -0.31284805051878 5.49032929933243e-23 NA NA NA hsa-miR-141-3p NCAM1 2.99777540204168 1.26370498493024e-78 -2.68069543446954 3.3168998510845e-39 TargetScan -0.495415877580315 3.84258736225889e-35 NA NA NA hsa-miR-182-5p NCAM1 2.36408084103818 2.60011457600281e-72 -2.68069543446954 3.3168998510845e-39 miRNATAP -0.566410378200588 1.9754106132518e-30 NA NA NA hsa-miR-200b-3p NCAM1 2.11744072703209 1.66710572104191e-43 -2.68069543446954 3.3168998510845e-39 TargetScan -0.425947803119043 1.0214634018228e-21 NA NA NA hsa-miR-200c-3p NCAM1 2.07038651806183 6.84613386286599e-51 -2.68069543446954 3.3168998510845e-39 miRTarBase -0.537372709763967 1.49098248094642e-28 NA NA NA hsa-miR-21-3p NCAM1 2.17476065946878 5.15299442583591e-75 -2.68069543446954 3.3168998510845e-39 MirTarget -0.402129081858758 6.05106097035372e-13 NA NA NA hsa-miR-210-3p NCAM1 2.38367203491819 3.73261999106754e-22 -2.68069543446954 3.3168998510845e-39 miRNAWalker2_validate;miRTarBase -0.157511637523919 5.07405639652084e-08 NA NA NA hsa-miR-375 NCAM1 2.09893673049766 1.68351780396203e-16 -2.68069543446954 3.3168998510845e-39 miRNAWalker2_validate;miRanda -0.198115775974143 1.485607378779e-12 NA NA NA hsa-miR-429 NCAM1 2.84108892259147 3.88520896426515e-64 -2.68069543446954 3.3168998510845e-39 PITA;miRanda;miRNATAP -0.391057901318253 6.21211990749002e-23 NA NA NA hsa-miR-96-5p NCAM1 3.24596558166606 1.92296159041707e-98 -2.68069543446954 3.3168998510845e-39 miRNATAP -0.500484144907707 1.19713141552974e-34 NA NA NA hsa-miR-452-5p NCAM2 -2.48486455572568 1.24430987974325e-33 0.177345362822011 0.486259778127611 mirMAP -0.356299124015064 3.73144417802513e-19 NA NA NA hsa-miR-486-5p NCAM2 -3.87258704301474 1.22658629378451e-80 0.177345362822011 0.486259778127611 miRanda -0.131765181090525 0.000648266725979162 NA NA NA hsa-miR-139-5p NCBP1 -3.25846663863766 2.62018989415003e-112 0.43542530620054 5.69857188161442e-14 miRanda -0.116474337783025 4.35482525362326e-23 NA NA NA hsa-miR-375 NCK2 2.09893673049766 1.68351780396203e-16 -0.17107267799518 0.0284008553186183 miRanda -0.121755499845819 5.16363636354373e-35 NA NA NA hsa-miR-429 NCOA1 2.84108892259147 3.88520896426515e-64 -0.712218181034353 8.49003995158387e-25 miRNATAP -0.107828520648172 4.42409753373096e-16 NA NA NA hsa-miR-200b-3p NCOA2 2.11744072703209 1.66710572104191e-43 -0.732997156847359 7.11379790206388e-05 TargetScan -0.104807825032694 0.00765794540747811 NA NA NA hsa-miR-429 NCOA2 2.84108892259147 3.88520896426515e-64 -0.732997156847359 7.11379790206388e-05 PITA;miRanda;miRNATAP -0.127842290302188 0.000262793772096997 NA NA NA hsa-miR-429 NCOA4 2.84108892259147 3.88520896426515e-64 -0.561440211528077 2.11656126005276e-16 miRanda -0.110620910816721 1.09715351514773e-17 NA NA NA hsa-miR-200b-3p NCOA7 2.11744072703209 1.66710572104191e-43 -1.46179265416623 4.61172460603693e-28 TargetScan -0.163489132778339 1.74079841724172e-08 NA NA NA hsa-miR-200c-3p NCOA7 2.07038651806183 6.84613386286599e-51 -1.46179265416623 4.61172460603693e-28 miRNATAP -0.180152899527411 1.62437726153357e-08 NA NA NA hsa-miR-375 NCOA7 2.09893673049766 1.68351780396203e-16 -1.46179265416623 4.61172460603693e-28 miRNAWalker2_validate;miRNATAP -0.208437591407756 7.82238254956279e-33 NA NA NA hsa-miR-429 NCOA7 2.84108892259147 3.88520896426515e-64 -1.46179265416623 4.61172460603693e-28 PITA;miRanda;miRNATAP -0.154372015138516 2.42803404852231e-09 NA NA NA hsa-miR-10b-5p NCS1 -2.10996264627796 7.36811595736367e-72 0.568386790128436 1.2704319261659e-07 mirMAP -0.22342726543336 3.75021292180213e-15 NA NA NA hsa-miR-99a-5p NDE1 -2.25079447371102 1.14086813185885e-54 0.875339226885404 7.92857237232874e-36 miRNAWalker2_validate -0.162147829873085 6.9207236050891e-25 NA NA NA hsa-miR-200b-3p NDN 2.11744072703209 1.66710572104191e-43 -1.89746127679983 3.59681018967678e-48 MirTarget;TargetScan -0.418648124026625 2.06991099599249e-52 NA NA NA hsa-miR-200c-3p NDN 2.07038651806183 6.84613386286599e-51 -1.89746127679983 3.59681018967678e-48 MirTarget;miRNATAP -0.537443968241421 7.51347077558241e-75 NA NA NA hsa-miR-429 NDN 2.84108892259147 3.88520896426515e-64 -1.89746127679983 3.59681018967678e-48 MirTarget;PITA;miRanda;miRNATAP -0.376580644513451 2.86406072710589e-53 NA NA NA hsa-miR-139-5p NDOR1 -3.25846663863766 2.62018989415003e-112 1.17447568640322 2.61068214721072e-43 mirMAP -0.162166177533301 3.18486005371714e-19 NA NA NA hsa-miR-182-5p NDRG1 2.36408084103818 2.60011457600281e-72 -0.538936716692747 0.000145098798891159 miRNATAP -0.231054892189196 5.45002194006732e-12 23874837 Additionally we demonstrated that miR-182 could downregulate expression of NDRG1 by directly targeting the NDRG1 3'-untranslated region; In conclusion our results suggest that miR-182 plays an important role in the proliferation of human prostate cancer cells by directly suppressing the tumor supressor gene NDRG1 prostate cancer hsa-miR-96-5p NDRG1 3.24596558166606 1.92296159041707e-98 -0.538936716692747 0.000145098798891159 TargetScan;miRNATAP -0.135640588482413 1.28058047821416e-06 NA NA NA hsa-miR-429 NDRG2 2.84108892259147 3.88520896426515e-64 -2.5572531779346 1.44945093855248e-67 miRNATAP -0.205679401280318 7.46813353798291e-12 NA NA NA hsa-miR-200c-3p NDST1 2.07038651806183 6.84613386286599e-51 -0.622870054013256 1.51055434858535e-18 miRNATAP -0.108411045470356 8.44309547512392e-11 NA NA NA hsa-miR-21-5p NDST1 2.32007501846389 3.08394781855554e-137 -0.622870054013256 1.51055434858535e-18 mirMAP -0.179688856545142 5.11311941039233e-16 NA NA NA hsa-miR-96-5p NDST1 3.24596558166606 1.92296159041707e-98 -0.622870054013256 1.51055434858535e-18 MirTarget;TargetScan -0.101911298846681 5.14509108723359e-13 NA NA NA hsa-miR-335-5p NDST3 -2.61355235628987 2.6462884165886e-51 0.179041889931925 0.404274614124658 miRNAWalker2_validate -0.119025909962675 0.00281866064920178 NA NA NA hsa-miR-10b-5p NDUFA11 -2.10996264627796 7.36811595736367e-72 0.617128360963213 6.77097765806991e-12 mirMAP -0.22735208271676 7.4668630549157e-22 NA NA NA hsa-miR-139-5p NDUFA11 -3.25846663863766 2.62018989415003e-112 0.617128360963213 6.77097765806991e-12 mirMAP -0.10739984079827 7.70845939947555e-09 NA NA NA hsa-miR-335-5p NDUFA11 -2.61355235628987 2.6462884165886e-51 0.617128360963213 6.77097765806991e-12 mirMAP -0.10721924361224 1.52650406888433e-10 NA NA NA hsa-miR-99a-5p NDUFA2 -2.25079447371102 1.14086813185885e-54 0.708025405377122 5.97634787767902e-15 miRNAWalker2_validate -0.19264803881003 3.94800054070842e-22 NA NA NA hsa-miR-10b-5p NDUFA4 -2.10996264627796 7.36811595736367e-72 0.361972473132136 3.81182653426758e-07 MirTarget -0.132746265340647 1.94591236796029e-12 NA NA NA hsa-miR-139-5p NDUFS3 -3.25846663863766 2.62018989415003e-112 0.51711024452 2.07454700883021e-15 miRanda -0.106234457804584 2.28851149411108e-15 NA NA NA hsa-miR-139-5p NDUFV2 -3.25846663863766 2.62018989415003e-112 0.471183736466793 2.49700056173202e-11 miRanda -0.107375969951432 1.24656224434449e-13 NA NA NA hsa-miR-452-5p NEBL -2.48486455572568 1.24430987974325e-33 0.357834855553593 0.00632966952412141 mirMAP -0.201271800427687 6.69238383669138e-23 NA NA NA hsa-miR-141-3p NECAB1 2.99777540204168 1.26370498493024e-78 -2.63199442138026 1.09732956901876e-54 MirTarget;TargetScan -0.464169765644387 5.07128486837852e-44 NA NA NA hsa-miR-182-5p NECAB1 2.36408084103818 2.60011457600281e-72 -2.63199442138026 1.09732956901876e-54 MirTarget -0.502510337751459 7.57178790259252e-34 NA NA NA hsa-miR-200a-3p NECAB1 2.55218480823434 2.96135446816238e-51 -2.63199442138026 1.09732956901876e-54 MirTarget -0.361970094879838 2.74901481318086e-27 NA NA NA hsa-miR-429 NEDD4 2.84108892259147 3.88520896426515e-64 -0.630802490935963 7.76484838971521e-11 miRanda -0.17002306859317 6.99857232705746e-21 NA NA NA hsa-miR-183-5p NEFL 2.95681814393872 1.09965777344285e-92 0.854166972573595 0.00113499981371097 MirTarget -0.176974281427004 0.00140304722536681 NA NA NA hsa-miR-200b-3p NEGR1 2.11744072703209 1.66710572104191e-43 -1.47578312334775 1.91555519072321e-16 TargetScan -0.38245958542877 3.67572271094342e-24 NA NA NA hsa-miR-200c-3p NEGR1 2.07038651806183 6.84613386286599e-51 -1.47578312334775 1.91555519072321e-16 miRNATAP -0.493083717095714 2.37755484081141e-33 NA NA NA hsa-miR-429 NEGR1 2.84108892259147 3.88520896426515e-64 -1.47578312334775 1.91555519072321e-16 PITA;miRanda;miRNATAP -0.374228404012857 4.96502346774555e-29 NA NA NA hsa-miR-21-5p NEK1 2.32007501846389 3.08394781855554e-137 -0.590616061010119 1.50282418517025e-14 miRNAWalker2_validate -0.22844427453076 5.82636584669598e-22 NA NA NA hsa-miR-429 NEK1 2.84108892259147 3.88520896426515e-64 -0.590616061010119 1.50282418517025e-14 miRanda -0.100364485299404 6.33023086884377e-12 NA NA NA hsa-miR-486-5p NEK2 -3.87258704301474 1.22658629378451e-80 4.82795784093813 2.08406476301305e-140 MirTarget;miRanda -0.491491391556638 1.24294881448698e-51 NA NA NA hsa-miR-429 NEK7 2.84108892259147 3.88520896426515e-64 -0.942778454433753 1.38729702631529e-32 miRNATAP -0.136668502157369 4.07733146841648e-19 NA NA NA hsa-miR-96-5p NEK7 3.24596558166606 1.92296159041707e-98 -0.942778454433753 1.38729702631529e-32 TargetScan -0.141121773391675 1.00944047505358e-18 NA NA NA hsa-miR-200c-3p NEK9 2.07038651806183 6.84613386286599e-51 -0.60343465464345 2.91093269226533e-23 MirTarget -0.131744594294364 1.79323167788526e-20 NA NA NA hsa-miR-21-3p NEK9 2.17476065946878 5.15299442583591e-75 -0.60343465464345 2.91093269226533e-23 MirTarget -0.162671251185901 1.99320336020851e-24 NA NA NA hsa-miR-429 NEK9 2.84108892259147 3.88520896426515e-64 -0.60343465464345 2.91093269226533e-23 MirTarget;miRanda -0.103274302308401 4.02032396176225e-19 NA NA NA hsa-miR-486-5p NELL2 -3.87258704301474 1.22658629378451e-80 1.31409315470539 2.21780186504788e-06 miRanda -0.140469362553955 0.000923169903273455 NA NA NA hsa-miR-486-5p NETO1 -3.87258704301474 1.22658629378451e-80 1.19651860079722 2.46833082363447e-05 miRanda -0.212939541987691 7.73883678540033e-07 NA NA NA hsa-miR-139-5p NETO2 -3.25846663863766 2.62018989415003e-112 0.571159591663464 0.000875776713347611 miRanda -0.238998712562796 8.808713416994e-12 NA NA NA hsa-miR-139-5p NEU1 -3.25846663863766 2.62018989415003e-112 0.795480012952627 1.34529583329152e-31 miRanda -0.131685995833886 1.85093968106289e-20 NA NA NA hsa-miR-375 NEUROG2 2.09893673049766 1.68351780396203e-16 -3.49220493818278 4.92374916601517e-33 miRanda -0.10200350297199 0.0109705473649656 NA NA NA hsa-miR-335-5p NFAM1 -2.61355235628987 2.6462884165886e-51 0.644027519340404 4.99538032735396e-08 mirMAP -0.121728648306145 2.991460126376e-08 NA NA NA hsa-miR-141-3p NFASC 2.99777540204168 1.26370498493024e-78 -1.57641481096258 2.66191878939881e-16 MirTarget;TargetScan;miRNATAP -0.10233741868113 0.0073061405796248 NA NA NA hsa-miR-182-5p NFASC 2.36408084103818 2.60011457600281e-72 -1.57641481096258 2.66191878939881e-16 mirMAP;miRNATAP -0.232352863580179 5.89256864464494e-07 NA NA NA hsa-miR-429 NFASC 2.84108892259147 3.88520896426515e-64 -1.57641481096258 2.66191878939881e-16 PITA;miRNATAP -0.10647416877478 0.00416812341376448 NA NA NA hsa-miR-103a-3p NFAT5 0.610673390034345 1.63113920514646e-12 -1.19902512228777 7.36927955059717e-50 MirTarget -0.336653367297422 1.28063362403024e-24 NA NA NA hsa-miR-106b-5p NFAT5 1.22477789913175 2.31787213143326e-32 -1.19902512228777 7.36927955059717e-50 MirTarget;miRNATAP -0.23715765114845 1.20613671461126e-18 NA NA NA hsa-miR-107 NFAT5 0.678998026350662 2.56224148930538e-16 -1.19902512228777 7.36927955059717e-50 MirTarget -0.295966190654869 8.65322066760854e-18 NA NA NA hsa-miR-1301-3p NFAT5 1.80754972811286 2.96809840886499e-36 -1.19902512228777 7.36927955059717e-50 MirTarget -0.114089558751608 4.42769113606664e-09 NA NA NA hsa-miR-141-3p NFAT5 2.99777540204168 1.26370498493024e-78 -1.19902512228777 7.36927955059717e-50 mirMAP -0.149337877858226 6.05474618072504e-20 NA NA NA hsa-miR-148b-3p NFAT5 1.0552576751879 1.6679285705231e-29 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.132221606001518 1.3758614517174e-05 NA NA NA hsa-miR-155-5p NFAT5 1.09766314984151 4.55650930885814e-15 -1.19902512228777 7.36927955059717e-50 mirMAP;miRNATAP -0.100566120170304 1.0444676030806e-06 NA NA NA hsa-miR-15a-5p NFAT5 0.812445324157528 4.50263417099822e-20 -1.19902512228777 7.36927955059717e-50 MirTarget -0.336948547662713 2.05581015414347e-26 NA NA NA hsa-miR-16-1-3p NFAT5 1.30142784811196 2.53343713753744e-29 -1.19902512228777 7.36927955059717e-50 mirMAP -0.204713975377917 1.41977903192804e-15 NA NA NA hsa-miR-17-3p NFAT5 0.721439431208839 7.95900548819742e-10 -1.19902512228777 7.36927955059717e-50 mirMAP -0.129870741981494 1.53941711137671e-07 NA NA NA hsa-miR-181a-5p NFAT5 0.635863607630183 6.72486918157744e-11 -1.19902512228777 7.36927955059717e-50 MirTarget;miRNATAP -0.187828472037995 2.67099255156267e-10 NA NA NA hsa-miR-181b-5p NFAT5 1.22749257795094 1.21998198830919e-27 -1.19902512228777 7.36927955059717e-50 MirTarget;miRNATAP -0.21216357383761 1.4174363007063e-17 NA NA NA hsa-miR-194-5p NFAT5 0.467781870340114 1.0386810618625e-07 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.127013805342984 0.000142318500250381 NA NA NA hsa-miR-200a-3p NFAT5 2.55218480823434 2.96135446816238e-51 -1.19902512228777 7.36927955059717e-50 mirMAP -0.120533278835972 8.59748977733914e-14 NA NA NA hsa-miR-21-3p NFAT5 2.17476065946878 5.15299442583591e-75 -1.19902512228777 7.36927955059717e-50 MirTarget -0.182888478641974 1.86723394339074e-16 NA NA NA hsa-miR-21-5p NFAT5 2.32007501846389 3.08394781855554e-137 -1.19902512228777 7.36927955059717e-50 miRNAWalker2_validate;mirMAP -0.34259926440926 2.90805980799457e-41 NA NA NA hsa-miR-32-5p NFAT5 1.38676603945192 2.29428299685976e-34 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.186203151817271 3.61328449313256e-14 NA NA NA hsa-miR-340-5p NFAT5 1.0857159627596 4.94471062546756e-24 -1.19902512228777 7.36927955059717e-50 MirTarget -0.253446045615689 2.48815325036697e-22 NA NA NA hsa-miR-361-5p NFAT5 -0.0996867547900457 0.095428250126326 -1.19902512228777 7.36927955059717e-50 MirTarget;PITA;mirMAP;miRNATAP -0.133459394718286 0.00775411722566547 NA NA NA hsa-miR-3613-5p NFAT5 1.11067990676844 4.33424951743633e-21 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.103018827085653 2.39140009917872e-05 NA NA NA hsa-miR-374a-3p NFAT5 0.34122393953022 2.28714105382856e-05 -1.19902512228777 7.36927955059717e-50 mirMAP -0.114187577439033 0.00184299941974274 NA NA NA hsa-miR-429 NFAT5 2.84108892259147 3.88520896426515e-64 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.139784505249335 1.85265208110627e-18 NA NA NA hsa-miR-590-3p NFAT5 1.27438512890514 1.03164723481469e-23 -1.19902512228777 7.36927955059717e-50 MirTarget;miRanda;mirMAP;miRNATAP -0.100697433581401 1.88485706745528e-05 NA NA NA hsa-miR-92b-3p NFAT5 1.30248132773644 9.42428674470985e-25 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.163288708475086 2.29328643304621e-13 NA NA NA hsa-miR-93-5p NFAT5 1.01788600209314 1.24312921618126e-21 -1.19902512228777 7.36927955059717e-50 MirTarget;miRNATAP -0.248552951648198 4.68674105390296e-21 NA NA NA hsa-miR-3127-5p NFATC1 0.903405128081314 1.1325923598273e-12 -0.574736307447025 1.59178190713337e-08 MirTarget -0.189661265640464 2.21630997061407e-12 NA NA NA hsa-miR-182-5p NFATC2 2.36408084103818 2.60011457600281e-72 -1.56755219359383 1.9388283538799e-13 mirMAP -0.319993630027942 3.80744800734882e-10 NA NA NA hsa-miR-185-5p NFATC2 0.482334746589337 3.68475879959415e-09 -1.56755219359383 1.9388283538799e-13 MirTarget -0.480154397877674 9.64194904728437e-08 NA NA NA hsa-miR-19a-3p NFATC2 0.817507952171848 3.76285090469625e-08 -1.56755219359383 1.9388283538799e-13 mirMAP -0.325063324024532 3.38278468154619e-11 NA NA NA hsa-miR-19b-3p NFATC2 0.139124391010031 0.255658553872934 -1.56755219359383 1.9388283538799e-13 mirMAP -0.287342497987003 2.05092326956767e-06 NA NA NA hsa-miR-200b-5p NFATC2 1.43091697052145 2.07975242866479e-22 -1.56755219359383 1.9388283538799e-13 mirMAP -0.148120269747522 0.0033400668976821 NA NA NA hsa-miR-30b-5p NFATC2 -0.46540603860146 2.4709940429591e-05 -1.56755219359383 1.9388283538799e-13 MirTarget;mirMAP -0.144039089526949 0.0321201787208961 NA NA NA hsa-miR-30c-5p NFATC2 -0.393222674580066 8.06961465717306e-05 -1.56755219359383 1.9388283538799e-13 MirTarget;mirMAP -0.18024743499037 0.0155205593365833 NA NA NA hsa-miR-320b NFATC2 0.412787504747938 0.00113457276903985 -1.56755219359383 1.9388283538799e-13 MirTarget -0.160231542240436 0.00642139736942507 NA NA NA hsa-miR-340-5p NFATC2 1.0857159627596 4.94471062546756e-24 -1.56755219359383 1.9388283538799e-13 miRNATAP -0.377355443179726 1.70562760392822e-08 NA NA NA hsa-miR-3613-5p NFATC2 1.11067990676844 4.33424951743633e-21 -1.56755219359383 1.9388283538799e-13 mirMAP -0.344189531636949 1.85303094879685e-08 NA NA NA hsa-miR-423-5p NFATC2 -0.0644843381453004 0.462275547464843 -1.56755219359383 1.9388283538799e-13 PITA -0.329350686391576 0.000107038916546868 NA NA NA hsa-miR-484 NFATC2 0.349444060004737 0.00154491249625173 -1.56755219359383 1.9388283538799e-13 MirTarget -0.151179681981917 0.0247912913976171 NA NA NA hsa-miR-590-3p NFATC2 1.27438512890514 1.03164723481469e-23 -1.56755219359383 1.9388283538799e-13 mirMAP -0.207787840865524 0.000469613853353843 NA NA NA hsa-miR-15a-5p NFATC3 0.812445324157528 4.50263417099822e-20 -0.588395366455362 8.23189760727994e-21 MirTarget;miRNATAP -0.231009103502432 3.55309483569134e-22 NA NA NA hsa-miR-185-5p NFATC3 0.482334746589337 3.68475879959415e-09 -0.588395366455362 8.23189760727994e-21 MirTarget;miRNATAP -0.124879744848212 3.18788249333561e-06 NA NA NA hsa-miR-29c-3p NFATC3 -0.0652732378039769 0.563774115756922 -0.588395366455362 8.23189760727994e-21 MirTarget;miRNATAP -0.133798476713389 4.59205597740966e-12 NA NA NA hsa-miR-340-5p NFATC3 1.0857159627596 4.94471062546756e-24 -0.588395366455362 8.23189760727994e-21 MirTarget -0.153252771292197 7.73680776852044e-15 NA NA NA hsa-miR-361-5p NFATC3 -0.0996867547900457 0.095428250126326 -0.588395366455362 8.23189760727994e-21 miRanda -0.178329966960041 1.80837796087919e-06 NA NA NA hsa-miR-130b-5p NFATC4 1.0573161199584 2.55177349228739e-12 0.464846681575293 0.00077326896248743 mirMAP -0.273306003041798 2.37279973423709e-19 NA NA NA hsa-miR-150-5p NFATC4 -0.832049526091211 3.45299201139224e-05 0.464846681575293 0.00077326896248743 mirMAP -0.127353989190525 5.08033729715864e-08 NA NA NA hsa-miR-15b-3p NFATC4 1.12898579025388 1.18050912917317e-14 0.464846681575293 0.00077326896248743 mirMAP -0.238062507407611 4.12345167097552e-14 NA NA NA hsa-miR-181a-2-3p NFATC4 -0.0718643470098321 0.422077954889554 0.464846681575293 0.00077326896248743 mirMAP -0.265900817473076 5.67846111588394e-07 NA NA NA hsa-miR-185-3p NFATC4 0.86591374114446 7.8790769678542e-10 0.464846681575293 0.00077326896248743 MirTarget -0.221463917308086 4.38182247561287e-11 NA NA NA hsa-miR-193a-3p NFATC4 0.310617999804917 0.00477640270974957 0.464846681575293 0.00077326896248743 miRanda -0.105543408753107 0.0146751830382174 NA NA NA hsa-miR-2355-5p NFATC4 -0.221733044425126 0.0231054202524677 0.464846681575293 0.00077326896248743 MirTarget -0.314673921460914 7.76236682155888e-11 NA NA NA hsa-miR-29a-3p NFATC4 -0.699539666833076 1.13935003139957e-13 0.464846681575293 0.00077326896248743 miRNATAP -0.159424686343472 0.00138862402245239 NA NA NA hsa-miR-29b-3p NFATC4 0.438847962603729 6.46722433236121e-05 0.464846681575293 0.00077326896248743 miRNATAP -0.122774285938033 0.00449585095871782 NA NA NA hsa-miR-3607-3p NFATC4 0.00697875745616461 0.972073275173643 0.464846681575293 0.00077326896248743 miRNATAP -0.103148919948283 1.40847070939603e-05 NA NA NA hsa-miR-361-3p NFATC4 -0.0370446538644886 0.624902392829872 0.464846681575293 0.00077326896248743 mirMAP -0.221299437804629 0.000469274259610322 NA NA NA hsa-miR-484 NFATC4 0.349444060004737 0.00154491249625173 0.464846681575293 0.00077326896248743 MirTarget;miRNATAP -0.195541918029345 5.21748391548856e-06 NA NA NA hsa-miR-532-5p NFATC4 0.0386976222860582 0.682018574136515 0.464846681575293 0.00077326896248743 mirMAP -0.351153097111496 2.13922805026231e-12 NA NA NA hsa-miR-629-3p NFATC4 1.25035919247365 3.91361135469024e-14 0.464846681575293 0.00077326896248743 mirMAP -0.222553384296637 1.10177313904365e-14 NA NA NA hsa-miR-139-5p NFE2L3 -3.25846663863766 2.62018989415003e-112 0.760818890956927 6.15302818950823e-09 miRanda -0.229718476931456 6.92579104730933e-18 NA NA NA hsa-miR-141-3p NFIA 2.99777540204168 1.26370498493024e-78 -0.857176611747856 7.06120416014585e-11 TargetScan;miRNATAP -0.149896213771147 5.12177143293541e-09 NA NA NA hsa-miR-141-5p NFIA 2.38411349683216 4.56310582620282e-58 -0.857176611747856 7.06120416014585e-11 miRNATAP -0.133631000782253 2.62691853961831e-06 NA NA NA hsa-miR-200a-3p NFIA 2.55218480823434 2.96135446816238e-51 -0.857176611747856 7.06120416014585e-11 miRNATAP -0.124471139488281 8.16997121235824e-07 NA NA NA hsa-miR-200a-5p NFIA 2.58844508672328 1.79650654234569e-56 -0.857176611747856 7.06120416014585e-11 MirTarget;miRNATAP -0.107703119247558 3.20819789498524e-05 NA NA NA hsa-miR-200b-3p NFIA 2.11744072703209 1.66710572104191e-43 -0.857176611747856 7.06120416014585e-11 MirTarget;TargetScan -0.136370657781913 1.19468664626153e-06 NA NA NA hsa-miR-200c-3p NFIA 2.07038651806183 6.84613386286599e-51 -0.857176611747856 7.06120416014585e-11 MirTarget;miRNATAP -0.189698437288321 6.84090134970592e-10 NA NA NA hsa-miR-21-5p NFIA 2.32007501846389 3.08394781855554e-137 -0.857176611747856 7.06120416014585e-11 MirTarget;miRNATAP -0.279890270029504 8.53158456489143e-12 NA NA NA hsa-miR-429 NFIA 2.84108892259147 3.88520896426515e-64 -0.857176611747856 7.06120416014585e-11 MirTarget;PITA;miRanda;miRNATAP -0.115358224214013 4.28039482447202e-06 NA NA NA hsa-miR-200a-3p NFIB 2.55218480823434 2.96135446816238e-51 -2.2930778520164 2.43578303149819e-46 mirMAP -0.234033880119789 2.6081515959604e-13 NA NA NA hsa-miR-200b-3p NFIB 2.11744072703209 1.66710572104191e-43 -2.2930778520164 2.43578303149819e-46 TargetScan -0.233757571008219 5.86506542792963e-11 NA NA NA hsa-miR-200c-3p NFIB 2.07038651806183 6.84613386286599e-51 -2.2930778520164 2.43578303149819e-46 miRNATAP -0.24001569104298 1.03974921818409e-09 NA NA NA hsa-miR-21-5p NFIB 2.32007501846389 3.08394781855554e-137 -2.2930778520164 2.43578303149819e-46 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.565176447004213 2.99659929184389e-28 NA NA NA hsa-miR-429 NFIB 2.84108892259147 3.88520896426515e-64 -2.2930778520164 2.43578303149819e-46 PITA;miRanda;miRNATAP -0.2170227713871 9.48620584277076e-12 NA NA NA hsa-miR-21-5p NFIC 2.32007501846389 3.08394781855554e-137 -0.323552442007893 0.00148597690443502 mirMAP -0.160493390478593 3.86214542438575e-07 NA NA NA hsa-miR-375 NFIX 2.09893673049766 1.68351780396203e-16 -1.22740758813951 7.60939451740798e-22 PITA;miRNATAP -0.103539215355137 1.57190527434386e-09 NA NA NA hsa-miR-429 NFIX 2.84108892259147 3.88520896426515e-64 -1.22740758813951 7.60939451740798e-22 miRNATAP -0.129708126713882 1.50341304734156e-07 NA NA NA hsa-miR-429 NFKBIZ 2.84108892259147 3.88520896426515e-64 -1.37319469901661 1.14883927757064e-14 miRanda -0.100956457127067 0.00319744673940403 NA NA NA hsa-miR-429 NGF 2.84108892259147 3.88520896426515e-64 -0.787725123054401 9.35669050853888e-08 miRanda -0.12206490353919 1.36541405382157e-05 NA NA NA hsa-miR-429 NGFR 2.84108892259147 3.88520896426515e-64 -2.50042294481334 5.32154099004444e-27 miRNATAP -0.365440513479821 3.03625910927681e-16 NA NA NA hsa-miR-21-5p NHLRC2 2.32007501846389 3.08394781855554e-137 -0.675891798900443 6.43662292606437e-09 mirMAP -0.292427290079013 4.45068908877516e-16 NA NA NA hsa-miR-200a-5p NHS 2.58844508672328 1.79650654234569e-56 -0.902790745847453 1.92581307600033e-12 miRNATAP -0.101335243295629 6.2945234901421e-05 NA NA NA hsa-miR-21-5p NHS 2.32007501846389 3.08394781855554e-137 -0.902790745847453 1.92581307600033e-12 mirMAP -0.125818575486007 0.00188922393602939 22776181 For the detection of mir21 capture probes and/or cell lysates were covalently attached onto the pencil graphite electrode PGE by coupling agents of N-dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride EDC and N-hydroxysulfosuccinimide NHS breast cancer hsa-miR-429 NHS 2.84108892259147 3.88520896426515e-64 -0.902790745847453 1.92581307600033e-12 miRNATAP -0.192732480086911 1.76585760852357e-15 NA NA NA hsa-miR-96-5p NHS 3.24596558166606 1.92296159041707e-98 -0.902790745847453 1.92581307600033e-12 TargetScan -0.187059712027786 1.59212119645575e-13 NA NA NA hsa-miR-183-5p NHSL2 2.95681814393872 1.09965777344285e-92 -1.57239325794111 7.63842470755102e-19 miRNAWalker2_validate -0.225846968130715 2.56110745895435e-09 NA NA NA hsa-miR-182-5p NID1 2.36408084103818 2.60011457600281e-72 -0.625003342677459 6.11281441039437e-08 MirTarget -0.222107510736194 3.45536301793608e-16 NA NA NA hsa-miR-429 NIPAL1 2.84108892259147 3.88520896426515e-64 -1.86378581414838 1.03707462075901e-14 miRanda -0.15445245826034 0.000867397334675965 NA NA NA hsa-miR-141-3p NIPAL2 2.99777540204168 1.26370498493024e-78 -0.846763626730118 4.81508775457977e-08 mirMAP -0.139176829235694 4.2925807542727e-06 NA NA NA hsa-miR-200a-3p NIPAL2 2.55218480823434 2.96135446816238e-51 -0.846763626730118 4.81508775457977e-08 mirMAP -0.167407733851061 1.57095367414392e-08 NA NA NA hsa-miR-21-5p NIPAL2 2.32007501846389 3.08394781855554e-137 -0.846763626730118 4.81508775457977e-08 MirTarget -0.207661042514944 1.92251727777557e-05 NA NA NA hsa-miR-21-5p NIPBL 2.32007501846389 3.08394781855554e-137 -0.3425889108838 7.30035932911777e-07 miRNAWalker2_validate -0.146219470940781 8.56025086385412e-12 NA NA NA hsa-miR-145-5p NIPSNAP1 -2.62703571936687 7.64402900188551e-88 1.15064562678506 4.6913047115871e-55 miRNAWalker2_validate -0.229313090452633 2.0106869959855e-39 NA NA NA hsa-miR-335-5p NIPSNAP1 -2.61355235628987 2.6462884165886e-51 1.15064562678506 4.6913047115871e-55 miRNAWalker2_validate -0.139137270488563 1.89624211640601e-22 NA NA NA hsa-miR-429 NIPSNAP3B 2.84108892259147 3.88520896426515e-64 -2.78696828513534 6.83594322919934e-98 miRanda -0.401378982524411 4.84878535184674e-51 NA NA NA hsa-miR-335-5p NKAIN1 -2.61355235628987 2.6462884165886e-51 3.58782119473036 3.15479732457313e-27 miRNAWalker2_validate -0.192303554555976 0.0025570571319498 NA NA NA hsa-miR-429 NKAIN2 2.84108892259147 3.88520896426515e-64 -1.85940071693835 4.47414860213548e-22 miRanda -0.332109787650889 1.24085097897136e-19 NA NA NA hsa-miR-96-5p NKAPL 3.24596558166606 1.92296159041707e-98 -2.81330319246176 6.28931491760101e-91 TargetScan -0.480192665409642 1.11698416479724e-63 NA NA NA hsa-let-7a-5p NKD1 -0.210286642041636 0.0072546234707717 0.687327063082442 3.30390073218128e-06 TargetScan -0.285119479952564 1.26690218381995e-05 NA NA NA hsa-miR-125a-5p NKD1 -0.635694700253268 3.6703235721638e-11 0.687327063082442 3.30390073218128e-06 miRanda -0.278399457854937 1.03346527875826e-07 NA NA NA hsa-miR-140-5p NKD1 -0.755971041589807 9.68060922934542e-14 0.687327063082442 3.30390073218128e-06 miRanda -0.100904832941356 0.0421314604872354 NA NA NA hsa-miR-330-5p NKD1 0.626063225953928 3.42215028606779e-09 0.687327063082442 3.30390073218128e-06 miRanda;miRNATAP -0.101487696032293 0.0339225254688308 NA NA NA hsa-miR-361-5p NKD1 -0.0996867547900457 0.095428250126326 0.687327063082442 3.30390073218128e-06 miRanda -0.242196570817123 0.00520088014824435 NA NA NA hsa-miR-532-5p NKD1 0.0386976222860582 0.682018574136515 0.687327063082442 3.30390073218128e-06 PITA;miRNATAP -0.121825130176435 0.0248596546919663 NA NA NA hsa-miR-125a-3p NKD2 -0.176412960953959 0.10108079286419 1.65375084549186 2.63931941990167e-19 miRanda -0.119765093394375 0.0474286895674221 NA NA NA hsa-miR-21-5p NKIRAS1 2.32007501846389 3.08394781855554e-137 -0.433544984516394 1.1986544676075e-10 MirTarget -0.215386848070623 1.12977727719919e-25 NA NA NA hsa-miR-21-5p NKTR 2.32007501846389 3.08394781855554e-137 -0.629435884388542 6.89137951173099e-16 miRNAWalker2_validate -0.209246344236617 6.0418343795957e-18 NA NA NA hsa-miR-139-5p NKX3-2 -3.25846663863766 2.62018989415003e-112 2.50502675415723 7.90203577292396e-30 miRanda -0.587207772473956 6.11272383692612e-39 NA NA NA hsa-miR-335-5p NKX3-2 -2.61355235628987 2.6462884165886e-51 2.50502675415723 7.90203577292396e-30 miRNAWalker2_validate -0.383069492969511 3.40006576339397e-20 NA NA NA hsa-miR-200a-5p NLGN1 2.58844508672328 1.79650654234569e-56 -3.7835062742775 6.74291502414997e-47 miRNATAP -0.51574538475085 2.92341104730807e-22 NA NA NA hsa-miR-200b-3p NLGN1 2.11744072703209 1.66710572104191e-43 -3.7835062742775 6.74291502414997e-47 mirMAP -0.531738282008383 4.1284353210261e-20 NA NA NA hsa-miR-429 NLGN1 2.84108892259147 3.88520896426515e-64 -3.7835062742775 6.74291502414997e-47 miRNATAP -0.535881175627145 1.62703794556955e-25 NA NA NA hsa-miR-182-5p NLGN4X 2.36408084103818 2.60011457600281e-72 -2.18618561323443 1.18944185794112e-21 miRNATAP -0.445182151782054 5.74690125027249e-16 NA NA NA hsa-miR-200b-3p NLGN4X 2.11744072703209 1.66710572104191e-43 -2.18618561323443 1.18944185794112e-21 TargetScan -0.32772964277698 2.87973503213682e-11 NA NA NA hsa-miR-200c-3p NLGN4X 2.07038651806183 6.84613386286599e-51 -2.18618561323443 1.18944185794112e-21 miRNATAP -0.428719634813815 1.74343119230385e-15 NA NA NA hsa-miR-21-3p NLGN4X 2.17476065946878 5.15299442583591e-75 -2.18618561323443 1.18944185794112e-21 MirTarget -0.316611991602362 2.58172134647992e-07 NA NA NA hsa-miR-429 NLGN4X 2.84108892259147 3.88520896426515e-64 -2.18618561323443 1.18944185794112e-21 PITA;miRanda;miRNATAP -0.350288596551171 1.15376606436417e-15 NA NA NA hsa-miR-96-5p NLGN4X 3.24596558166606 1.92296159041707e-98 -2.18618561323443 1.18944185794112e-21 miRNATAP -0.425016972193121 6.9417282581067e-21 NA NA NA hsa-let-7i-5p NLK -0.333419326258177 3.56960810786801e-08 0.568183653225175 4.68554951142873e-14 miRNATAP -0.413862391863088 2.49706725878225e-22 NA NA NA hsa-miR-132-3p NLK -0.0365213889238607 0.668598301088667 0.568183653225175 4.68554951142873e-14 miRNATAP -0.147434106687348 1.72134800695252e-06 NA NA NA hsa-miR-139-5p NLK -3.25846663863766 2.62018989415003e-112 0.568183653225175 4.68554951142873e-14 miRanda -0.103239444031536 3.35421799377228e-11 NA NA NA hsa-miR-140-5p NLK -0.755971041589807 9.68060922934542e-14 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.139208185186153 3.98951586060413e-08 NA NA NA hsa-miR-146b-5p NLK 0.631041661167954 6.20366593452965e-08 0.568183653225175 4.68554951142873e-14 miRanda -0.130772865651309 3.748420957412e-09 NA NA NA hsa-miR-152-3p NLK -0.26603867075042 0.0063861560676033 0.568183653225175 4.68554951142873e-14 MirTarget -0.121964596915363 5.58054397729548e-06 NA NA NA hsa-miR-195-3p NLK -1.49582726452416 6.53261924105147e-40 0.568183653225175 4.68554951142873e-14 mirMAP -0.145388282098103 3.0064135076299e-11 NA NA NA hsa-miR-199b-5p NLK -1.37022396448377 3.25758057539223e-26 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.130208304038465 2.10468258720444e-11 NA NA NA hsa-miR-217 NLK -0.616728851115349 8.64977119332241e-05 0.568183653225175 4.68554951142873e-14 miRanda -0.107421092941157 6.83560697467638e-11 NA NA NA hsa-miR-221-3p NLK -0.317970198201501 0.00910855267413448 0.568183653225175 4.68554951142873e-14 MirTarget;miRNATAP -0.160004395790496 4.50992101797211e-14 NA NA NA hsa-miR-24-3p NLK -0.120123317289941 0.21432376743243 0.568183653225175 4.68554951142873e-14 miRNATAP -0.110962647460226 4.40407432880344e-05 NA NA NA hsa-miR-25-3p NLK -0.00546790775985073 0.944061771389468 0.568183653225175 4.68554951142873e-14 MirTarget;miRNATAP -0.106492227212925 0.0017026454555609 NA NA NA hsa-miR-26a-5p NLK -0.481180084102235 1.82368246174758e-10 0.568183653225175 4.68554951142873e-14 miRNATAP -0.184587948058077 8.44159773363628e-08 NA NA NA hsa-miR-27a-3p NLK 0.388496361379095 1.42373532086331e-05 0.568183653225175 4.68554951142873e-14 miRNATAP -0.108956811004123 0.000196776667929282 NA NA NA hsa-miR-27b-3p NLK -0.0796803270437447 0.410503155574393 0.568183653225175 4.68554951142873e-14 miRNATAP -0.115578430021538 2.04956118003642e-05 NA NA NA hsa-miR-28-5p NLK -0.14267073663385 0.0497619246260571 0.568183653225175 4.68554951142873e-14 miRanda -0.182841180159811 4.4803820168759e-07 NA NA NA hsa-miR-381-3p NLK -1.28028930293369 1.61402949866141e-23 0.568183653225175 4.68554951142873e-14 MirTarget -0.176789380063327 1.23463667918594e-19 NA NA NA hsa-miR-455-5p NLK 0.284641224662773 0.0357572339594277 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.123543532954721 1.15133287100025e-10 NA NA NA hsa-miR-485-3p NLK -0.866822427729628 4.5194665263492e-11 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRNATAP -0.115025747481124 5.816614344041e-09 NA NA NA hsa-miR-92a-3p NLK -0.342420481092807 0.000732275969501111 0.568183653225175 4.68554951142873e-14 MirTarget;miRNATAP -0.108248489207265 2.75005198560074e-05 NA NA NA hsa-miR-429 NLRP3 2.84108892259147 3.88520896426515e-64 -0.737975798815318 4.48535059919219e-10 miRanda -0.192009283184111 5.28722428394804e-18 NA NA NA hsa-miR-335-5p NLRP7 -2.61355235628987 2.6462884165886e-51 1.09475759261967 1.90718096191645e-05 miRNAWalker2_validate -0.151790974427183 0.00148348798911493 NA NA NA hsa-miR-486-5p NME1 -3.87258704301474 1.22658629378451e-80 1.75175582085889 6.02591482135127e-57 miRanda -0.160109060067642 8.64064043151188e-20 NA NA NA hsa-miR-139-5p NMI -3.25846663863766 2.62018989415003e-112 0.335931993934794 0.000246155322027681 miRanda -0.105869988819081 1.70442324052787e-08 NA NA NA hsa-miR-141-3p NMNAT2 2.99777540204168 1.26370498493024e-78 -3.00997488398387 7.40983336735889e-47 miRNATAP -0.459097254377581 4.326625246712e-28 NA NA NA hsa-miR-200a-3p NMNAT2 2.55218480823434 2.96135446816238e-51 -3.00997488398387 7.40983336735889e-47 miRNATAP -0.382254263797924 2.70376384151858e-20 NA NA NA hsa-miR-429 NMNAT2 2.84108892259147 3.88520896426515e-64 -3.00997488398387 7.40983336735889e-47 miRNATAP -0.412457875451239 7.09466191965637e-24 NA NA NA hsa-miR-429 NMT2 2.84108892259147 3.88520896426515e-64 -2.01894313797623 3.95731655221293e-79 miRanda -0.268525647117652 7.80631493605717e-36 NA NA NA hsa-miR-429 NOD1 2.84108892259147 3.88520896426515e-64 -0.765280780665763 3.29992956756684e-33 miRanda -0.101465342188298 1.95271564386223e-16 NA NA NA hsa-miR-486-5p NOD2 -3.87258704301474 1.22658629378451e-80 1.38151427259084 7.32145150666836e-22 miRanda -0.188061781992677 1.22268755803573e-17 NA NA NA hsa-miR-200b-3p NOG 2.11744072703209 1.66710572104191e-43 -0.838623753380888 3.81907058171582e-05 MirTarget;TargetScan -0.249677853882184 6.65837437098035e-09 NA NA NA hsa-miR-200c-3p NOG 2.07038651806183 6.84613386286599e-51 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.347080893351845 1.63065263678635e-13 NA NA NA hsa-miR-429 NOG 2.84108892259147 3.88520896426515e-64 -0.838623753380888 3.81907058171582e-05 MirTarget;PITA;miRanda;miRNATAP -0.221990432368383 7.7539335905232e-09 NA NA NA hsa-miR-10b-5p NONO -2.10996264627796 7.36811595736367e-72 0.459023073800221 2.28719291172275e-23 MirTarget;miRNATAP -0.153426668090499 2.74430002066912e-37 NA NA NA hsa-miR-139-5p NOP16 -3.25846663863766 2.62018989415003e-112 0.905111752732448 9.11829618881373e-25 miRanda -0.18323190388186 6.23179230495003e-24 NA NA NA hsa-miR-224-5p NOS1AP -2.22249420723892 1.07787949391113e-18 -0.675518736834807 0.00068091520217485 mirMAP -0.172748198450688 4.61841813863436e-11 NA NA NA hsa-miR-429 NOS3 2.84108892259147 3.88520896426515e-64 -0.415857403289588 4.78627333883668e-05 miRanda -0.130650037890721 1.06798855882441e-11 NA NA NA hsa-miR-452-5p NOSTRIN -2.48486455572568 1.24430987974325e-33 -1.12031736035685 6.61663289423426e-09 miRNATAP -0.173686899148375 1.96996161118543e-08 NA NA NA hsa-miR-200c-3p NOTCH1 2.07038651806183 6.84613386286599e-51 -0.553015677374277 2.02877481257167e-09 MirTarget -0.137198353882731 1.74966723790763e-10 NA NA NA hsa-miR-429 NOTCH4 2.84108892259147 3.88520896426515e-64 -1.50526235529601 1.47560609551127e-52 miRNATAP -0.260770350652043 3.61460632580394e-43 NA NA NA hsa-miR-429 NOV 2.84108892259147 3.88520896426515e-64 -1.81869578299293 7.22422441587638e-32 miRanda -0.334303220179491 6.94975744279115e-30 NA NA NA hsa-miR-141-3p NOVA1 2.99777540204168 1.26370498493024e-78 -2.64865943147083 1.81019532722592e-21 miRNATAP -0.455179055575006 6.98163050399199e-17 NA NA NA hsa-miR-200a-5p NOVA1 2.58844508672328 1.79650654234569e-56 -2.64865943147083 1.81019532722592e-21 miRNATAP -0.369343740117438 2.19020149409596e-11 NA NA NA hsa-miR-200b-3p NOVA1 2.11744072703209 1.66710572104191e-43 -2.64865943147083 1.81019532722592e-21 MirTarget;TargetScan -0.312507475991292 2.14282541846265e-07 NA NA NA hsa-miR-200c-3p NOVA1 2.07038651806183 6.84613386286599e-51 -2.64865943147083 1.81019532722592e-21 MirTarget;miRNATAP -0.435472416622821 3.98141218541127e-11 NA NA NA hsa-miR-429 NOVA1 2.84108892259147 3.88520896426515e-64 -2.64865943147083 1.81019532722592e-21 MirTarget;PITA;miRanda;miRNATAP -0.444422726084054 6.01974385699661e-17 NA NA NA hsa-miR-96-5p NOVA1 3.24596558166606 1.92296159041707e-98 -2.64865943147083 1.81019532722592e-21 TargetScan;miRNATAP -0.33968144186545 1.31317488942078e-09 NA NA NA hsa-miR-182-5p NOVA2 2.36408084103818 2.60011457600281e-72 -0.814094895411407 2.48019030681192e-17 mirMAP -0.164494042660013 9.86252294151318e-13 NA NA NA hsa-miR-183-5p NOVA2 2.95681814393872 1.09965777344285e-92 -0.814094895411407 2.48019030681192e-17 mirMAP -0.199907619152013 2.82329147346706e-23 NA NA NA hsa-miR-200b-3p NOVA2 2.11744072703209 1.66710572104191e-43 -0.814094895411407 2.48019030681192e-17 TargetScan -0.182088283827237 3.71187269446586e-19 NA NA NA hsa-miR-429 NOVA2 2.84108892259147 3.88520896426515e-64 -0.814094895411407 2.48019030681192e-17 miRNATAP -0.176298588121823 2.01755511427105e-22 NA NA NA hsa-miR-96-5p NOVA2 3.24596558166606 1.92296159041707e-98 -0.814094895411407 2.48019030681192e-17 TargetScan -0.143493676680426 5.87819122424815e-14 NA NA NA hsa-miR-335-5p NPAS1 -2.61355235628987 2.6462884165886e-51 1.51918116545623 1.11246063841078e-13 miRNAWalker2_validate -0.191963509707587 5.76104672239209e-07 NA NA NA hsa-miR-141-3p NPAS3 2.99777540204168 1.26370498493024e-78 -1.77844651192273 1.0067661120746e-29 TargetScan;miRNATAP -0.242069947480667 8.29228867700514e-15 NA NA NA hsa-miR-183-5p NPAS3 2.95681814393872 1.09965777344285e-92 -1.77844651192273 1.0067661120746e-29 miRNATAP -0.323418087643351 4.47665831816407e-22 NA NA NA hsa-miR-196a-5p NPAS3 2.33423717464504 3.646557504928e-18 -1.77844651192273 1.0067661120746e-29 miRNATAP -0.113582918784671 1.81016462114316e-08 NA NA NA hsa-miR-200a-3p NPAS3 2.55218480823434 2.96135446816238e-51 -1.77844651192273 1.0067661120746e-29 miRNATAP -0.144889953989086 2.82653031116822e-06 NA NA NA hsa-miR-21-5p NPAS3 2.32007501846389 3.08394781855554e-137 -1.77844651192273 1.0067661120746e-29 miRNATAP -0.426485107404944 1.10681961838438e-17 NA NA NA hsa-miR-96-5p NPAS3 3.24596558166606 1.92296159041707e-98 -1.77844651192273 1.0067661120746e-29 TargetScan -0.305367025175142 2.35923646924206e-22 NA NA NA hsa-miR-452-5p NPEPPS -2.48486455572568 1.24430987974325e-33 0.0898837764128464 0.248999962066843 MirTarget;miRNATAP -0.114171843834003 5.55421940163219e-21 NA NA NA hsa-miR-452-5p NPHP1 -2.48486455572568 1.24430987974325e-33 -0.297196407663332 0.00253432264826826 MirTarget -0.145175127955314 3.72260622588147e-21 NA NA NA hsa-miR-200a-5p NPHP3 2.58844508672328 1.79650654234569e-56 -1.34224966029455 8.55488789455459e-68 MirTarget -0.163524899946069 1.07314991443235e-24 NA NA NA hsa-miR-139-5p NPNT -3.25846663863766 2.62018989415003e-112 1.30537723017584 8.93205976672538e-11 miRanda -0.212964127590799 3.28433433093201e-07 NA NA NA hsa-miR-429 NPR3 2.84108892259147 3.88520896426515e-64 -2.07791377201139 2.77958352244167e-18 miRanda -0.265564966079796 6.56524224226765e-09 NA NA NA hsa-miR-141-3p NPTX1 2.99777540204168 1.26370498493024e-78 -1.16799175041166 3.39387172426866e-07 TargetScan;miRNATAP -0.170457276662152 0.000139099213331284 NA NA NA hsa-miR-182-5p NPTX1 2.36408084103818 2.60011457600281e-72 -1.16799175041166 3.39387172426866e-07 miRNATAP -0.162980629664173 0.00301121780890885 NA NA NA hsa-miR-200a-3p NPTX1 2.55218480823434 2.96135446816238e-51 -1.16799175041166 3.39387172426866e-07 miRNATAP -0.154228269466061 0.000446107782490342 NA NA NA hsa-miR-200b-3p NPTX1 2.11744072703209 1.66710572104191e-43 -1.16799175041166 3.39387172426866e-07 TargetScan -0.128716549748498 0.00852590605865368 NA NA NA hsa-miR-210-3p NPTX1 2.38367203491819 3.73261999106754e-22 -1.16799175041166 3.39387172426866e-07 miRNAWalker2_validate;miRTarBase -0.166802332792593 7.58993437746375e-08 NA NA NA hsa-miR-429 NPTX1 2.84108892259147 3.88520896426515e-64 -1.16799175041166 3.39387172426866e-07 PITA;miRanda;miRNATAP -0.165637304754007 0.000145181733719633 NA NA NA hsa-miR-96-5p NPTX1 3.24596558166606 1.92296159041707e-98 -1.16799175041166 3.39387172426866e-07 TargetScan -0.216679621294144 1.81494411389364e-06 NA NA NA hsa-miR-429 NPY1R 2.84108892259147 3.88520896426515e-64 -1.52169405684191 6.56590694323722e-05 miRanda -0.158662657049567 0.0288107931544959 NA NA NA hsa-miR-375 NPY2R 2.09893673049766 1.68351780396203e-16 -6.45797875341372 3.62051092663934e-66 miRanda -0.24132197662179 7.06363645304762e-06 NA NA NA hsa-miR-429 NPY2R 2.84108892259147 3.88520896426515e-64 -6.45797875341372 3.62051092663934e-66 miRanda -0.750061016825952 2.57924746288711e-23 NA NA NA hsa-miR-141-5p NPY5R 2.38411349683216 4.56310582620282e-58 -3.79741403186492 8.53610165385027e-27 MirTarget -0.433858442387948 2.80450394600644e-08 NA NA NA hsa-miR-182-5p NR1D2 2.36408084103818 2.60011457600281e-72 -1.06285306245612 2.47515484589492e-35 miRNATAP -0.12509898690544 3.28710601038443e-09 NA NA NA hsa-miR-429 NR1D2 2.84108892259147 3.88520896426515e-64 -1.06285306245612 2.47515484589492e-35 miRNATAP -0.128626236267332 1.2780679790672e-14 NA NA NA hsa-miR-96-5p NR1D2 3.24596558166606 1.92296159041707e-98 -1.06285306245612 2.47515484589492e-35 miRNATAP -0.131315465319715 4.9620987558605e-14 NA NA NA hsa-miR-21-5p NR2C2 2.32007501846389 3.08394781855554e-137 -0.69937931634491 2.08140222646562e-12 miRNAWalker2_validate -0.280718605434827 6.56731465445451e-20 NA NA NA hsa-miR-335-5p NR2F6 -2.61355235628987 2.6462884165886e-51 1.33238024561843 1.47388975725665e-51 miRNAWalker2_validate -0.149499982254393 2.54922104415434e-18 NA NA NA hsa-miR-141-3p NR3C1 2.99777540204168 1.26370498493024e-78 -1.90095759546805 1.53460991213052e-74 TargetScan -0.343681157500495 9.06380333369764e-63 NA NA NA hsa-miR-182-5p NR3C1 2.36408084103818 2.60011457600281e-72 -1.90095759546805 1.53460991213052e-74 miRNATAP -0.369458040410652 8.60872425460217e-47 NA NA NA hsa-miR-183-5p NR3C1 2.95681814393872 1.09965777344285e-92 -1.90095759546805 1.53460991213052e-74 miRNATAP -0.358017314016354 2.6185908719873e-57 NA NA NA hsa-miR-200b-3p NR3C1 2.11744072703209 1.66710572104191e-43 -1.90095759546805 1.53460991213052e-74 TargetScan -0.337372770790606 1.77296680876202e-49 NA NA NA hsa-miR-200c-3p NR3C1 2.07038651806183 6.84613386286599e-51 -1.90095759546805 1.53460991213052e-74 miRNATAP -0.371677069904956 1.11379726422763e-49 NA NA NA hsa-miR-429 NR3C1 2.84108892259147 3.88520896426515e-64 -1.90095759546805 1.53460991213052e-74 PITA;miRanda;miRNATAP -0.333439097619954 3.79560901086674e-62 NA NA NA hsa-miR-96-5p NR3C1 3.24596558166606 1.92296159041707e-98 -1.90095759546805 1.53460991213052e-74 miRNATAP -0.364656099455469 2.96527369539304e-69 NA NA NA hsa-miR-429 NR4A2 2.84108892259147 3.88520896426515e-64 -1.00418520415067 2.70589249007797e-09 miRanda -0.149995583574573 3.08213760299521e-06 NA NA NA hsa-miR-96-5p NR4A3 3.24596558166606 1.92296159041707e-98 -2.0443205135814 2.87626270400426e-26 TargetScan -0.402392758673031 5.90708698156788e-26 NA NA NA hsa-miR-200b-3p NR5A2 2.11744072703209 1.66710572104191e-43 -1.73641167176698 2.75266532164922e-42 TargetScan -0.34850566037163 1.6552775442547e-37 NA NA NA hsa-miR-200c-3p NR5A2 2.07038651806183 6.84613386286599e-51 -1.73641167176698 2.75266532164922e-42 miRNATAP -0.419106017589978 2.07076264682248e-45 NA NA NA hsa-miR-429 NR5A2 2.84108892259147 3.88520896426515e-64 -1.73641167176698 2.75266532164922e-42 PITA;miRanda;miRNATAP -0.325352785862458 3.23937018286003e-41 NA NA NA hsa-miR-10b-5p NRARP -2.10996264627796 7.36811595736367e-72 0.661554507392887 3.69227435276987e-11 mirMAP -0.159441203783316 2.46275241670669e-09 NA NA NA hsa-miR-452-5p NRCAM -2.48486455572568 1.24430987974325e-33 0.272789333557431 0.187855821318992 MirTarget -0.151058712476026 4.6086562821616e-06 NA NA NA hsa-miR-183-5p NRG1 2.95681814393872 1.09965777344285e-92 -2.72776391585681 2.94582737368582e-26 miRNATAP -0.518936571929881 2.24993557509224e-21 NA NA NA hsa-miR-200b-3p NRG1 2.11744072703209 1.66710572104191e-43 -2.72776391585681 2.94582737368582e-26 TargetScan -0.31024356281559 3.0026683074848e-08 NA NA NA hsa-miR-200c-3p NRG1 2.07038651806183 6.84613386286599e-51 -2.72776391585681 2.94582737368582e-26 miRNATAP -0.323125631959935 1.57615403899138e-07 NA NA NA hsa-miR-429 NRG1 2.84108892259147 3.88520896426515e-64 -2.72776391585681 2.94582737368582e-26 miRanda;miRNATAP -0.371468025141836 7.1285795173174e-14 NA NA NA hsa-miR-429 NRG3 2.84108892259147 3.88520896426515e-64 -1.44484694950152 2.64707593692206e-10 miRanda -0.127858946256251 0.00350226446948099 NA NA NA hsa-miR-183-5p NRIP2 2.95681814393872 1.09965777344285e-92 -1.27701277217795 1.90624617498963e-35 MirTarget -0.269298691714894 1.96186490828124e-35 NA NA NA hsa-miR-429 NRK 2.84108892259147 3.88520896426515e-64 -0.683327357612967 0.00387203725161182 miRanda;miRNATAP -0.252372000158339 1.49659675483815e-08 NA NA NA hsa-miR-96-5p NRN1 3.24596558166606 1.92296159041707e-98 -2.42462279681781 3.30585619128386e-66 TargetScan -0.459047788201414 9.37768145507509e-60 NA NA NA hsa-miR-141-3p NRP1 2.99777540204168 1.26370498493024e-78 -1.2092340225481 1.60964437652292e-34 TargetScan;miRNATAP -0.322660970639545 3.55229816484165e-69 NA NA NA hsa-miR-200a-3p NRP1 2.55218480823434 2.96135446816238e-51 -1.2092340225481 1.60964437652292e-34 miRNATAP -0.273214054014354 1.63053938383069e-49 NA NA NA hsa-miR-429 NRP1 2.84108892259147 3.88520896426515e-64 -1.2092340225481 1.60964437652292e-34 miRanda;miRNATAP -0.264479982914876 8.2706207008821e-47 NA NA NA hsa-miR-141-3p NRP2 2.99777540204168 1.26370498493024e-78 -0.314375201116318 0.00328594709032875 TargetScan;miRNATAP -0.20383369370909 7.86735325447486e-24 NA NA NA hsa-miR-183-5p NRP2 2.95681814393872 1.09965777344285e-92 -0.314375201116318 0.00328594709032875 miRNATAP -0.159836297660086 7.21982854120502e-13 NA NA NA hsa-miR-200a-3p NRP2 2.55218480823434 2.96135446816238e-51 -0.314375201116318 0.00328594709032875 miRNATAP -0.188013235877061 4.14457924607267e-21 NA NA NA hsa-miR-200b-3p NRP2 2.11744072703209 1.66710572104191e-43 -0.314375201116318 0.00328594709032875 TargetScan -0.212257754560826 9.83458332289623e-22 NA NA NA hsa-miR-429 NRP2 2.84108892259147 3.88520896426515e-64 -0.314375201116318 0.00328594709032875 PITA;miRanda;miRNATAP -0.159020289730599 1.5813522116666e-15 NA NA NA hsa-miR-141-3p NRXN1 2.99777540204168 1.26370498493024e-78 -3.41422669412462 5.50578926594407e-34 MirTarget;TargetScan;miRNATAP -0.410752175399023 2.73817334395559e-13 NA NA NA hsa-miR-141-5p NRXN1 2.38411349683216 4.56310582620282e-58 -3.41422669412462 5.50578926594407e-34 MirTarget -0.379453241617457 1.20222352516105e-09 NA NA NA hsa-miR-196a-5p NRXN1 2.33423717464504 3.646557504928e-18 -3.41422669412462 5.50578926594407e-34 miRNAWalker2_validate;miRNATAP -0.117538623093809 0.00129345777063719 NA NA NA hsa-miR-200a-3p NRXN1 2.55218480823434 2.96135446816238e-51 -3.41422669412462 5.50578926594407e-34 MirTarget;miRNATAP -0.346873612712336 3.77182743238562e-10 NA NA NA hsa-miR-429 NRXN1 2.84108892259147 3.88520896426515e-64 -3.41422669412462 5.50578926594407e-34 miRanda -0.371506684773794 1.31449609340612e-11 NA NA NA hsa-miR-96-5p NRXN1 3.24596558166606 1.92296159041707e-98 -3.41422669412462 5.50578926594407e-34 miRNATAP -0.392590656936008 7.22001146759896e-12 NA NA NA hsa-miR-429 NRXN2 2.84108892259147 3.88520896426515e-64 -0.294681162492725 0.0633836394105675 miRNATAP -0.152120843252609 3.66050420037554e-07 NA NA NA hsa-miR-200b-3p NTF3 2.11744072703209 1.66710572104191e-43 -2.35193065681614 1.75397805257351e-24 TargetScan -0.321874947951398 1.05323715646676e-10 NA NA NA hsa-miR-200c-3p NTF3 2.07038651806183 6.84613386286599e-51 -2.35193065681614 1.75397805257351e-24 miRNAWalker2_validate;miRNATAP -0.405535845133949 1.08735324650309e-13 NA NA NA hsa-miR-21-5p NTF3 2.32007501846389 3.08394781855554e-137 -2.35193065681614 1.75397805257351e-24 miRTarBase;miRNATAP -0.481266108265449 4.86045305948914e-11 NA NA NA hsa-miR-429 NTF3 2.84108892259147 3.88520896426515e-64 -2.35193065681614 1.75397805257351e-24 PITA;miRanda;miRNATAP -0.318352061640753 7.25173081695566e-13 NA NA NA hsa-miR-429 NTM 2.84108892259147 3.88520896426515e-64 0.221487289190883 0.123560204043128 miRanda;miRNATAP -0.116202019495312 1.87021588467903e-05 NA NA NA hsa-miR-182-5p NTN4 2.36408084103818 2.60011457600281e-72 -1.66322280404212 2.8363707662969e-15 miRNATAP -0.138457163990674 0.00671677781949965 NA NA NA hsa-miR-183-5p NTN4 2.95681814393872 1.09965777344285e-92 -1.66322280404212 2.8363707662969e-15 MirTarget -0.340811878091377 1.8765020737608e-14 NA NA NA hsa-miR-196a-5p NTN4 2.33423717464504 3.646557504928e-18 -1.66322280404212 2.8363707662969e-15 MirTarget -0.100026317774459 0.000178040591774004 24120501 miR 196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells; Only netrin 4 NTN4 expression displayed an inverse association with miR-196a; Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3'-untranslated region 3'-UTR of NTN4 mRNA; Furthermore qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression cervical and endocervical cancer hsa-miR-429 NTN4 2.84108892259147 3.88520896426515e-64 -1.66322280404212 2.8363707662969e-15 miRanda -0.254525028913466 2.46449904800466e-10 NA NA NA hsa-miR-96-5p NTN4 3.24596558166606 1.92296159041707e-98 -1.66322280404212 2.8363707662969e-15 MirTarget;TargetScan;miRNATAP -0.28130717588561 1.92869859971421e-11 NA NA NA hsa-miR-182-5p NTNG1 2.36408084103818 2.60011457600281e-72 -0.158099145237109 0.633216192592288 MirTarget -0.255332315047455 0.00120206582789318 NA NA NA hsa-miR-182-5p NTRK2 2.36408084103818 2.60011457600281e-72 -4.03565225718056 9.2986992242195e-64 mirMAP -0.570548474380832 3.49801193738836e-21 NA NA NA hsa-miR-200c-3p NTRK2 2.07038651806183 6.84613386286599e-51 -4.03565225718056 9.2986992242195e-64 miRNAWalker2_validate;miRTarBase -0.540459062838814 7.12630091174492e-20 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-21-5p NTRK2 2.32007501846389 3.08394781855554e-137 -4.03565225718056 9.2986992242195e-64 mirMAP -1.20592530757402 1.06429280476928e-57 NA NA NA hsa-miR-429 NTRK2 2.84108892259147 3.88520896426515e-64 -4.03565225718056 9.2986992242195e-64 PITA;miRanda;miRNATAP -0.51698534306774 1.82175500468262e-27 NA NA NA hsa-miR-141-3p NTRK3 2.99777540204168 1.26370498493024e-78 -2.79779489905708 1.23029392356612e-24 mirMAP -0.458491365569119 1.29868070797624e-17 NA NA NA hsa-miR-182-5p NTRK3 2.36408084103818 2.60011457600281e-72 -2.79779489905708 1.23029392356612e-24 mirMAP -0.437926257298233 4.10809632659201e-11 NA NA NA hsa-miR-200a-3p NTRK3 2.55218480823434 2.96135446816238e-51 -2.79779489905708 1.23029392356612e-24 mirMAP -0.338470573748645 1.9148717552399e-10 NA NA NA hsa-miR-200a-5p NTRK3 2.58844508672328 1.79650654234569e-56 -2.79779489905708 1.23029392356612e-24 mirMAP -0.310767388659839 1.22677450947795e-08 NA NA NA hsa-miR-21-3p NTRK3 2.17476065946878 5.15299442583591e-75 -2.79779489905708 1.23029392356612e-24 mirMAP -0.650567608924442 2.9249016148128e-19 NA NA NA hsa-miR-21-5p NTRK3 2.32007501846389 3.08394781855554e-137 -2.79779489905708 1.23029392356612e-24 mirMAP -0.741881394491742 6.39690202997752e-18 NA NA NA hsa-miR-375 NTRK3 2.09893673049766 1.68351780396203e-16 -2.79779489905708 1.23029392356612e-24 miRNATAP -0.219039344247601 2.68063141796075e-09 NA NA NA hsa-miR-96-5p NTRK3 3.24596558166606 1.92296159041707e-98 -2.79779489905708 1.23029392356612e-24 mirMAP -0.487971497453581 3.27122249403384e-19 NA NA NA hsa-miR-10b-5p NTSR1 -2.10996264627796 7.36811595736367e-72 1.51782491073833 1.01238837465263e-09 mirMAP -0.566087078719545 6.34695035807215e-18 NA NA NA hsa-miR-335-5p NTSR1 -2.61355235628987 2.6462884165886e-51 1.51782491073833 1.01238837465263e-09 miRNAWalker2_validate -0.267443671429985 7.63426434239819e-09 NA NA NA hsa-miR-182-5p NUAK1 2.36408084103818 2.60011457600281e-72 -0.914610809156931 1.8807905701441e-17 MirTarget;miRNATAP -0.165838715245779 1.51585853364283e-10 NA NA NA hsa-miR-96-5p NUAK1 3.24596558166606 1.92296159041707e-98 -0.914610809156931 1.8807905701441e-17 TargetScan;miRNATAP -0.20692274406299 1.30570497297089e-22 NA NA NA hsa-miR-145-5p NUAK2 -2.62703571936687 7.64402900188551e-88 2.20281585866602 3.89561828942553e-79 MirTarget -0.393991012100002 1.45523667056704e-43 NA NA NA hsa-miR-139-5p NUBP2 -3.25846663863766 2.62018989415003e-112 1.20762314319654 3.76258180401048e-32 miRanda -0.193878809547413 1.4911432960377e-19 NA NA NA hsa-miR-21-5p NUBPL 2.32007501846389 3.08394781855554e-137 -0.534904774967847 2.15581528012604e-13 miRNAWalker2_validate -0.216534064807805 5.34923384769218e-22 NA NA NA hsa-miR-145-5p NUDT1 -2.62703571936687 7.64402900188551e-88 1.1327988039844 9.21559149300805e-27 miRTarBase -0.256925946439927 1.83830847661055e-25 21289483 MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis lung cancer hsa-miR-429 NUDT10 2.84108892259147 3.88520896426515e-64 -0.486454176304683 0.00918423125601976 miRNATAP -0.183808293042615 1.788024382924e-07 NA NA NA hsa-miR-486-5p NUDT10 -3.87258704301474 1.22658629378451e-80 -0.486454176304683 0.00918423125601976 miRanda -0.105623332164738 0.000195123753141662 NA NA NA hsa-miR-429 NUDT11 2.84108892259147 3.88520896426515e-64 -1.04136919208265 1.67326288376621e-10 miRanda -0.219824502014414 1.00029319717368e-12 NA NA NA hsa-miR-21-5p NUDT16 2.32007501846389 3.08394781855554e-137 -0.445428153690895 2.21401027903386e-11 mirMAP -0.130900603359444 2.9323217792533e-10 NA NA NA hsa-miR-139-5p NUDT19 -3.25846663863766 2.62018989415003e-112 0.486495610547162 5.24159520659475e-09 miRanda -0.117947945828576 5.13015092047909e-12 NA NA NA hsa-miR-139-5p NUP210 -3.25846663863766 2.62018989415003e-112 2.09636622115365 4.65070854679666e-75 miRanda -0.36755151234166 9.00174197686627e-52 NA NA NA hsa-miR-335-5p NUP210 -2.61355235628987 2.6462884165886e-51 2.09636622115365 4.65070854679666e-75 miRNAWalker2_validate -0.219654685905798 5.34661175124607e-22 NA NA NA hsa-miR-139-5p NUP37 -3.25846663863766 2.62018989415003e-112 0.351295687842441 1.04890601296089e-09 miRanda -0.111531555431252 1.03392481783789e-21 NA NA NA hsa-miR-335-5p NUPR1 -2.61355235628987 2.6462884165886e-51 0.445572780626023 0.000479764143408036 miRNAWalker2_validate -0.118837552032039 5.00226932833132e-07 NA NA NA hsa-miR-139-5p NUTF2 -3.25846663863766 2.62018989415003e-112 0.565925133278395 1.5998618029219e-13 miRanda -0.142309968510334 1.0218308036846e-19 NA NA NA hsa-miR-511-5p NXPH1 -2.27545475897362 3.84085514050558e-36 0.903973885598446 0.037365261428271 MirTarget -0.388630381983542 7.9731669068052e-07 NA NA NA hsa-miR-335-5p OAS1 -2.61355235628987 2.6462884165886e-51 1.12902350579886 7.26610568794228e-14 miRNAWalker2_validate -0.1108254129969 9.56450708495952e-05 NA NA NA hsa-miR-139-5p OAS2 -3.25846663863766 2.62018989415003e-112 1.17346164591443 5.93578964327051e-14 miRanda -0.242208770866189 5.5177822450366e-14 NA NA NA hsa-miR-335-5p OAS2 -2.61355235628987 2.6462884165886e-51 1.17346164591443 5.93578964327051e-14 miRNAWalker2_validate -0.119849100089926 4.60693344558728e-05 NA NA NA hsa-miR-139-5p OAS3 -3.25846663863766 2.62018989415003e-112 1.12223950283 4.99713660378603e-16 mirMAP -0.233754999795144 2.39822015604627e-16 NA NA NA hsa-miR-224-5p OCLN -2.22249420723892 1.07787949391113e-18 0.905784824324477 7.43057386940643e-11 MirTarget -0.107443429617349 7.26122201955664e-09 NA NA NA hsa-miR-335-5p ODF3B -2.61355235628987 2.6462884165886e-51 0.449667352414454 0.000750153261209942 miRNAWalker2_validate -0.109216428272937 1.02611667747946e-05 NA NA NA hsa-miR-335-5p OGDHL -2.61355235628987 2.6462884165886e-51 0.413086342655014 0.167184706927923 miRNAWalker2_validate -0.156518471103129 0.00484225625265111 NA NA NA hsa-miR-139-5p OGFOD2 -3.25846663863766 2.62018989415003e-112 0.768950423578224 7.36172275217637e-18 miRanda -0.107780820800264 7.06855521258298e-09 NA NA NA hsa-miR-96-5p OGFRL1 3.24596558166606 1.92296159041707e-98 -1.07484825771252 7.31652372240349e-20 TargetScan -0.149168613981496 2.68202417576177e-10 NA NA NA hsa-miR-429 OGN 2.84108892259147 3.88520896426515e-64 -3.74251776056207 6.49487466193206e-39 miRanda -0.719884071151354 4.5471663387038e-40 NA NA NA hsa-miR-139-5p OIP5 -3.25846663863766 2.62018989415003e-112 2.85802114814649 1.46821590587703e-84 miRanda -0.54863989589369 3.18899827523329e-71 NA NA NA hsa-miR-141-3p OLFM1 2.99777540204168 1.26370498493024e-78 -0.806833993567473 2.33080631095537e-05 MirTarget;TargetScan;miRNATAP -0.203164969416503 3.98805762929319e-08 NA NA NA hsa-miR-200a-3p OLFM1 2.55218480823434 2.96135446816238e-51 -0.806833993567473 2.33080631095537e-05 MirTarget;miRNATAP -0.161242066229165 9.49214433672516e-06 NA NA NA hsa-miR-141-3p OLFML2A 2.99777540204168 1.26370498493024e-78 -1.23279838858358 1.44822780058179e-34 mirMAP -0.255375418553711 1.92866577906841e-39 NA NA NA hsa-miR-200a-3p OLFML2A 2.55218480823434 2.96135446816238e-51 -1.23279838858358 1.44822780058179e-34 mirMAP -0.202472969940008 1.899890371669e-25 NA NA NA hsa-miR-429 OLFML2A 2.84108892259147 3.88520896426515e-64 -1.23279838858358 1.44822780058179e-34 miRanda -0.2192489135162 2.64757606342038e-30 NA NA NA hsa-miR-10b-5p ONECUT2 -2.10996264627796 7.36811595736367e-72 0.838418671812549 0.0134553608090962 miRNATAP -0.398625143191882 9.92070640651642e-06 NA NA NA hsa-miR-145-5p ONECUT2 -2.62703571936687 7.64402900188551e-88 0.838418671812549 0.0134553608090962 mirMAP;miRNATAP -0.186900423670462 0.0179286823151424 NA NA NA hsa-miR-200a-5p OPCML 2.58844508672328 1.79650654234569e-56 -0.152585446356833 0.475856153293485 mirMAP -0.140456534921769 0.000763281737686843 NA NA NA hsa-miR-429 OPCML 2.84108892259147 3.88520896426515e-64 -0.152585446356833 0.475856153293485 miRNATAP -0.175745663418653 1.34888887520808e-05 NA NA NA hsa-miR-139-5p OPN3 -3.25846663863766 2.62018989415003e-112 0.594661371965447 2.28807925987572e-07 miRanda -0.169244403825411 6.08124231192103e-13 NA NA NA hsa-miR-182-5p OPTN 2.36408084103818 2.60011457600281e-72 -0.741881184913097 4.28720027494807e-17 MirTarget -0.204047069286864 1.57136189667075e-22 NA NA NA hsa-miR-141-5p OR51E1 2.38411349683216 4.56310582620282e-58 -0.638705559464131 2.54663599620975e-06 MirTarget -0.196720101723953 1.15891170818219e-11 NA NA NA hsa-miR-429 OR51E1 2.84108892259147 3.88520896426515e-64 -0.638705559464131 2.54663599620975e-06 PITA;miRanda -0.165037847462637 1.14814530779922e-10 NA NA NA hsa-miR-10b-5p ORAI2 -2.10996264627796 7.36811595736367e-72 1.11855441049396 1.05545169663653e-50 miRNAWalker2_validate -0.209323258913791 3.07756401120476e-24 NA NA NA hsa-miR-10b-5p ORAOV1 -2.10996264627796 7.36811595736367e-72 0.521534019290149 4.48144156743056e-08 mirMAP -0.167287667317576 3.93404331462349e-11 NA NA NA hsa-miR-200b-3p OSBPL11 2.11744072703209 1.66710572104191e-43 -0.367137294663096 1.23945889750395e-08 MirTarget;TargetScan -0.105453058697228 7.28318528942807e-15 NA NA NA hsa-miR-200c-3p OSBPL11 2.07038651806183 6.84613386286599e-51 -0.367137294663096 1.23945889750395e-08 MirTarget;miRNATAP -0.104825958660084 2.3997622115761e-12 NA NA NA hsa-miR-141-3p OSBPL1A 2.99777540204168 1.26370498493024e-78 -1.13066391229894 4.52776339430695e-36 TargetScan -0.121306246132155 2.15527685962491e-11 NA NA NA hsa-miR-21-5p OSBPL1A 2.32007501846389 3.08394781855554e-137 -1.13066391229894 4.52776339430695e-36 miRNAWalker2_validate -0.425153912368914 4.94510902429643e-54 NA NA NA hsa-miR-429 OSBPL1A 2.84108892259147 3.88520896426515e-64 -1.13066391229894 4.52776339430695e-36 miRanda -0.119891713254357 1.09485024598667e-11 NA NA NA hsa-miR-200a-3p OSBPL6 2.55218480823434 2.96135446816238e-51 0.353016330690283 0.0415531126921937 MirTarget;miRNATAP -0.118363724930756 0.000334864651178065 NA NA NA hsa-miR-200b-3p OSBPL6 2.11744072703209 1.66710572104191e-43 0.353016330690283 0.0415531126921937 mirMAP -0.100093368453257 0.00647596894415949 NA NA NA hsa-miR-141-3p OSBPL8 2.99777540204168 1.26370498493024e-78 -0.597116166688471 4.67806844867655e-09 MirTarget -0.103660628751314 1.82391401359925e-07 NA NA NA hsa-miR-429 OSBPL8 2.84108892259147 3.88520896426515e-64 -0.597116166688471 4.67806844867655e-09 miRanda -0.103716834334317 8.38165420849057e-08 NA NA NA hsa-miR-139-5p OSCAR -3.25846663863766 2.62018989415003e-112 1.4122499189374 1.24438766238201e-31 miRanda -0.259817962972604 3.87679055255479e-25 NA NA NA hsa-miR-200b-3p OSMR 2.11744072703209 1.66710572104191e-43 -0.668362253183246 2.80577564076125e-06 TargetScan -0.20408879563362 1.18112518586047e-11 NA NA NA hsa-miR-429 OSMR 2.84108892259147 3.88520896426515e-64 -0.668362253183246 2.80577564076125e-06 miRanda;miRNATAP -0.181544786242502 1.42143787332253e-11 NA NA NA hsa-miR-200b-3p OSR1 2.11744072703209 1.66710572104191e-43 -3.16852677493185 4.80968425126363e-31 TargetScan -0.292970121454762 1.04579720835767e-06 NA NA NA hsa-miR-200c-3p OSR1 2.07038651806183 6.84613386286599e-51 -3.16852677493185 4.80968425126363e-31 miRNATAP -0.443368946680984 1.34911561063052e-11 NA NA NA hsa-miR-21-5p OSR1 2.32007501846389 3.08394781855554e-137 -3.16852677493185 4.80968425126363e-31 miRNAWalker2_validate;MirTarget;miRNATAP -0.670120706978658 1.59937973029098e-14 NA NA NA hsa-miR-429 OSR1 2.84108892259147 3.88520896426515e-64 -3.16852677493185 4.80968425126363e-31 miRNATAP -0.369378934473919 3.81857620047258e-12 NA NA NA hsa-miR-200b-3p OSTM1 2.11744072703209 1.66710572104191e-43 -0.528607916390317 6.96950270756952e-16 MirTarget;TargetScan -0.176145840991316 4.22722946472316e-39 NA NA NA hsa-miR-200c-3p OSTM1 2.07038651806183 6.84613386286599e-51 -0.528607916390317 6.96950270756952e-16 MirTarget -0.208993700977901 5.00724824993472e-46 NA NA NA hsa-miR-429 OSTM1 2.84108892259147 3.88520896426515e-64 -0.528607916390317 6.96950270756952e-16 MirTarget;miRanda;miRNATAP -0.138108511890618 7.71067630401904e-30 NA NA NA hsa-miR-139-5p OTOR -3.25846663863766 2.62018989415003e-112 1.67200174032581 2.54106586061581e-10 miRanda -0.219392843048892 6.44188478372256e-05 NA NA NA hsa-miR-335-5p OTOR -2.61355235628987 2.6462884165886e-51 1.67200174032581 2.54106586061581e-10 miRNAWalker2_validate -0.133890884058646 0.00702998081336058 NA NA NA hsa-miR-335-5p OTUB1 -2.61355235628987 2.6462884165886e-51 0.743708114973462 2.76727756237135e-34 mirMAP -0.106475962841822 2.33484815782277e-20 NA NA NA hsa-miR-139-5p OTUB2 -3.25846663863766 2.62018989415003e-112 1.04819143562664 1.51953841962343e-30 miRanda -0.242568259214687 6.44127927617282e-39 NA NA NA hsa-miR-21-5p OTUD1 2.32007501846389 3.08394781855554e-137 -0.694177218076327 1.03987378100653e-25 miRNAWalker2_validate -0.182699663266022 1.77150193510907e-18 NA NA NA hsa-miR-21-5p OTUD4 2.32007501846389 3.08394781855554e-137 -0.488821980404331 2.33380397709048e-11 mirMAP -0.186108493333786 2.0478953360265e-16 NA NA NA hsa-miR-429 OXCT1 2.84108892259147 3.88520896426515e-64 -1.11334530026218 3.09090807587136e-20 miRanda -0.162091627466753 2.52679681662533e-12 NA NA NA hsa-miR-429 OXGR1 2.84108892259147 3.88520896426515e-64 -3.04217511604401 2.90734693477055e-24 miRanda -0.244087400515779 2.77423345835052e-05 NA NA NA hsa-miR-96-5p OXGR1 3.24596558166606 1.92296159041707e-98 -3.04217511604401 2.90734693477055e-24 MirTarget -0.558773861842236 6.36582603383417e-21 NA NA NA hsa-miR-96-5p OXR1 3.24596558166606 1.92296159041707e-98 -0.643230667767379 8.18644577894952e-13 miRNATAP -0.113104176335538 2.26989469520033e-10 NA NA NA hsa-miR-141-3p P2RX6 2.99777540204168 1.26370498493024e-78 -2.54903747820754 2.16948536748351e-36 mirMAP -0.449371623952927 1.2120829487478e-29 NA NA NA hsa-miR-200a-3p P2RX6 2.55218480823434 2.96135446816238e-51 -2.54903747820754 2.16948536748351e-36 mirMAP -0.350136112048884 8.61282914522302e-19 NA NA NA hsa-miR-141-3p P2RY1 2.99777540204168 1.26370498493024e-78 -0.850118686903185 2.14298043474504e-07 TargetScan -0.268507511975452 1.48074248609534e-17 NA NA NA hsa-miR-429 P2RY1 2.84108892259147 3.88520896426515e-64 -0.850118686903185 2.14298043474504e-07 miRanda -0.248618201774869 6.11854517114582e-16 NA NA NA hsa-miR-99a-5p P2RY11 -2.25079447371102 1.14086813185885e-54 2.64228535831328 8.23265587975533e-14 miRNAWalker2_validate -0.342047893307387 1.64391990228057e-05 NA NA NA hsa-miR-429 P2RY12 2.84108892259147 3.88520896426515e-64 -3.13284303882613 5.68894825267287e-51 miRanda -0.459750791857822 1.35730138746681e-29 NA NA NA hsa-miR-335-5p P4HA1 -2.61355235628987 2.6462884165886e-51 0.746424771614336 4.54935324779091e-15 miRNAWalker2_validate -0.115849255627972 7.6259602693858e-11 NA NA NA hsa-miR-335-5p P4HA3 -2.61355235628987 2.6462884165886e-51 2.92168859968224 6.57488210061713e-63 miRNAWalker2_validate -0.327615840183649 1.15455980923045e-21 NA NA NA hsa-miR-10b-5p PABPC1 -2.10996264627796 7.36811595736367e-72 0.351560673797163 9.16418722604915e-05 miRNAWalker2_validate -0.164068845439909 4.78095377670138e-12 NA NA NA hsa-miR-139-5p PABPC1 -3.25846663863766 2.62018989415003e-112 0.351560673797163 9.16418722604915e-05 miRanda -0.142092902453706 7.3486974632358e-15 NA NA NA hsa-miR-429 PABPC4L 2.84108892259147 3.88520896426515e-64 -1.14922777540174 1.99807869542171e-19 miRanda -0.184454130655737 3.57434370947644e-14 NA NA NA hsa-miR-335-5p PACSIN1 -2.61355235628987 2.6462884165886e-51 2.60354489213897 3.2081245146144e-63 mirMAP -0.239945961153045 5.86591274750559e-15 NA NA NA hsa-miR-21-5p PAIP2B 2.32007501846389 3.08394781855554e-137 -1.06485866035276 3.93283854681351e-18 miRNATAP -0.368977512874348 3.28168682317723e-22 NA NA NA hsa-miR-200b-3p PAK3 2.11744072703209 1.66710572104191e-43 -3.72979901479568 2.02151045164573e-57 TargetScan -0.377458116576707 7.1482577050122e-13 NA NA NA hsa-miR-96-5p PAK3 3.24596558166606 1.92296159041707e-98 -3.72979901479568 2.02151045164573e-57 TargetScan -0.678741357461716 1.34911750627433e-47 NA NA NA hsa-miR-145-5p PAK4 -2.62703571936687 7.64402900188551e-88 1.47186288644382 7.37718156197043e-58 miRNAWalker2_validate;miRTarBase -0.326408303596423 4.52801469396177e-52 23499891 We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4 colon cancer hsa-miR-182-5p PALLD 2.36408084103818 2.60011457600281e-72 -0.455797085130606 3.59581638086629e-06 MirTarget;miRNATAP -0.146838278536892 3.11461266813864e-10 NA NA NA hsa-miR-96-5p PALLD 3.24596558166606 1.92296159041707e-98 -0.455797085130606 3.59581638086629e-06 miRNATAP -0.156869380494003 3.16165846647171e-16 NA NA NA hsa-miR-200b-3p PALM2 2.11744072703209 1.66710572104191e-43 -0.653931714558236 2.40323003337382e-05 TargetScan -0.171817597461909 1.6125973826136e-07 NA NA NA hsa-miR-21-5p PALM2 2.32007501846389 3.08394781855554e-137 -0.653931714558236 2.40323003337382e-05 mirMAP -0.180722451708013 0.000187496241366861 NA NA NA hsa-miR-375 PALM2 2.09893673049766 1.68351780396203e-16 -0.653931714558236 2.40323003337382e-05 mirMAP -0.165035255507717 2.653858145928e-16 NA NA NA hsa-miR-429 PALM2 2.84108892259147 3.88520896426515e-64 -0.653931714558236 2.40323003337382e-05 PITA;miRanda -0.105624651085881 0.000328917109026902 NA NA NA hsa-miR-141-3p PALM2-AKAP2 2.99777540204168 1.26370498493024e-78 -2.18061520132683 2.36003120512481e-93 TargetScan;miRNATAP -0.412788028638882 3.72804347535648e-87 NA NA NA hsa-miR-200a-3p PALM2-AKAP2 2.55218480823434 2.96135446816238e-51 -2.18061520132683 2.36003120512481e-93 miRNATAP -0.334520266778723 1.49700561854671e-55 NA NA NA hsa-miR-200a-5p PALM2-AKAP2 2.58844508672328 1.79650654234569e-56 -2.18061520132683 2.36003120512481e-93 mirMAP -0.330370612606999 3.07813261804764e-51 NA NA NA hsa-miR-200b-3p PALM2-AKAP2 2.11744072703209 1.66710572104191e-43 -2.18061520132683 2.36003120512481e-93 TargetScan -0.361522510969298 4.2525667342449e-52 NA NA NA hsa-miR-200c-3p PALM2-AKAP2 2.07038651806183 6.84613386286599e-51 -2.18061520132683 2.36003120512481e-93 miRNATAP -0.446952227497301 4.95966968545459e-68 NA NA NA hsa-miR-429 PALM2-AKAP2 2.84108892259147 3.88520896426515e-64 -2.18061520132683 2.36003120512481e-93 miRanda;miRNATAP -0.334957372343228 1.40391568085386e-56 NA NA NA hsa-miR-141-5p PAM 2.38411349683216 4.56310582620282e-58 -0.95135206643246 1.04094267312042e-17 MirTarget -0.220448678251673 1.85842775387849e-20 NA NA NA hsa-miR-183-5p PAM 2.95681814393872 1.09965777344285e-92 -0.95135206643246 1.04094267312042e-17 MirTarget;miRNATAP -0.226285477680896 2.43475129988812e-22 NA NA NA hsa-miR-200b-3p PAM 2.11744072703209 1.66710572104191e-43 -0.95135206643246 1.04094267312042e-17 TargetScan -0.200182296378385 2.08577420531689e-17 NA NA NA hsa-miR-200c-3p PAM 2.07038651806183 6.84613386286599e-51 -0.95135206643246 1.04094267312042e-17 miRNATAP -0.255377027741016 3.26611360579356e-23 NA NA NA hsa-miR-429 PAM 2.84108892259147 3.88520896426515e-64 -0.95135206643246 1.04094267312042e-17 PITA;miRanda;miRNATAP -0.170974237989048 5.30968065817211e-16 NA NA NA hsa-miR-21-5p PAN3 2.32007501846389 3.08394781855554e-137 -0.34151410640205 6.19556904085374e-07 miRNAWalker2_validate;MirTarget -0.160513810946105 3.14035145929224e-14 NA NA NA hsa-miR-139-5p PANK1 -3.25846663863766 2.62018989415003e-112 0.241666262428942 0.0801546047259449 miRanda -0.104551588556929 0.000229744172766866 NA NA NA hsa-miR-452-5p PANK3 -2.48486455572568 1.24430987974325e-33 0.276061257918443 0.00865077517028964 mirMAP -0.143084526532804 3.95075988895581e-18 NA NA NA hsa-miR-141-3p PAPLN 2.99777540204168 1.26370498493024e-78 -0.934616468378652 1.68697270659172e-12 TargetScan -0.251246552133318 4.78996719843743e-23 NA NA NA hsa-miR-200b-3p PAPLN 2.11744072703209 1.66710572104191e-43 -0.934616468378652 1.68697270659172e-12 TargetScan -0.18607595576945 3.98686757828339e-11 NA NA NA hsa-miR-21-5p PAPOLG 2.32007501846389 3.08394781855554e-137 -0.287774887323626 5.36679293444006e-06 mirMAP -0.133272137049725 9.31455072221333e-12 NA NA NA hsa-miR-141-3p PAPPA 2.99777540204168 1.26370498493024e-78 -0.728679548360849 1.50074730316036e-06 MirTarget;TargetScan;miRNATAP -0.257212200581169 7.50120124816377e-19 NA NA NA hsa-miR-182-5p PAPPA 2.36408084103818 2.60011457600281e-72 -0.728679548360849 1.50074730316036e-06 MirTarget -0.214695736300024 2.4871735994159e-09 NA NA NA hsa-miR-200a-3p PAPPA 2.55218480823434 2.96135446816238e-51 -0.728679548360849 1.50074730316036e-06 MirTarget;miRNATAP -0.225418193938018 3.20106293266592e-15 NA NA NA hsa-miR-429 PAPPA 2.84108892259147 3.88520896426515e-64 -0.728679548360849 1.50074730316036e-06 miRNATAP -0.22280196124319 4.38622098013909e-15 NA NA NA hsa-miR-96-5p PAPPA 3.24596558166606 1.92296159041707e-98 -0.728679548360849 1.50074730316036e-06 TargetScan;miRNATAP -0.254424431366543 7.1576367586216e-18 NA NA NA hsa-miR-375 PAPSS2 2.09893673049766 1.68351780396203e-16 -0.461710787649865 0.00692436810210827 miRanda -0.129630277264201 7.27615537106171e-09 NA NA NA hsa-miR-429 PAPSS2 2.84108892259147 3.88520896426515e-64 -0.461710787649865 0.00692436810210827 miRanda -0.182733408019915 1.38216569834128e-08 NA NA NA hsa-miR-335-5p PAQR6 -2.61355235628987 2.6462884165886e-51 1.60943279897312 2.68392875563164e-18 miRNAWalker2_validate -0.244866089745122 1.44200717832027e-12 NA NA NA hsa-miR-375 PAQR8 2.09893673049766 1.68351780396203e-16 -0.224703622453253 0.00974704297652146 miRNAWalker2_validate -0.110780954835934 3.40464893422916e-23 NA NA NA hsa-miR-96-5p PAQR8 3.24596558166606 1.92296159041707e-98 -0.224703622453253 0.00974704297652146 TargetScan -0.12581961495487 1.15915194675449e-13 NA NA NA hsa-miR-200b-3p PARD3B 2.11744072703209 1.66710572104191e-43 -1.79470831891467 1.2314875552622e-23 MirTarget;TargetScan;mirMAP -0.305639472422353 1.91199782696716e-15 NA NA NA hsa-miR-200c-3p PARD3B 2.07038651806183 6.84613386286599e-51 -1.79470831891467 1.2314875552622e-23 MirTarget;miRNATAP -0.351954866959227 7.59360613509706e-17 NA NA NA hsa-miR-21-3p PARD3B 2.17476065946878 5.15299442583591e-75 -1.79470831891467 1.2314875552622e-23 MirTarget -0.287554730474084 2.28416361346111e-09 NA NA NA hsa-miR-429 PARD3B 2.84108892259147 3.88520896426515e-64 -1.79470831891467 1.2314875552622e-23 MirTarget;miRNATAP -0.325659417717079 1.16878990371903e-21 NA NA NA hsa-miR-96-5p PARD3B 3.24596558166606 1.92296159041707e-98 -1.79470831891467 1.2314875552622e-23 TargetScan -0.321142700339323 2.15076237652113e-19 NA NA NA hsa-miR-335-5p PARD6B -2.61355235628987 2.6462884165886e-51 1.70997497031339 2.55366919190462e-20 miRNAWalker2_validate -0.129495953426302 0.000232202714037223 NA NA NA hsa-miR-429 PARK2 2.84108892259147 3.88520896426515e-64 -2.19468141268174 4.59309191568931e-55 miRanda -0.334735575654818 1.98913086864751e-34 NA NA NA hsa-miR-182-5p PARM1 2.36408084103818 2.60011457600281e-72 -1.52406675705941 4.35164695925674e-28 MirTarget;miRNATAP -0.287568472403114 1.02105148009087e-17 NA NA NA hsa-miR-335-5p PARP10 -2.61355235628987 2.6462884165886e-51 1.1497189652811 2.65810088706284e-18 miRNAWalker2_validate -0.188563166501843 1.94744258423008e-14 NA NA NA hsa-miR-375 PARP15 2.09893673049766 1.68351780396203e-16 -0.317557340101165 0.0912814583622492 miRanda -0.13903017285142 1.65259892712365e-08 NA NA NA hsa-miR-96-5p PARP15 3.24596558166606 1.92296159041707e-98 -0.317557340101165 0.0912814583622492 MirTarget -0.200941108261152 5.36605868687939e-08 NA NA NA hsa-miR-429 PARP8 2.84108892259147 3.88520896426515e-64 -0.455686342314426 0.000606041961716729 miRanda -0.12880251732911 2.86132012295626e-07 NA NA NA hsa-miR-429 PARVA 2.84108892259147 3.88520896426515e-64 -0.983307300506994 6.1666432826974e-44 miRanda -0.174660938403714 2.55531118405986e-38 NA NA NA hsa-miR-139-5p PATZ1 -3.25846663863766 2.62018989415003e-112 0.545967892240467 7.84550263072544e-13 miRanda -0.105098270113406 2.30356471349635e-11 NA NA NA hsa-miR-141-3p PAX3 2.99777540204168 1.26370498493024e-78 -2.25919597564541 4.32944093751082e-20 TargetScan -0.452976558660758 2.86306645105671e-21 NA NA NA hsa-miR-96-5p PAX5 3.24596558166606 1.92296159041707e-98 0.186405982880343 0.536149721725608 TargetScan -0.170147195857531 0.00426814964317596 NA NA NA hsa-miR-182-5p PAX6 2.36408084103818 2.60011457600281e-72 -0.533423063226729 6.23825479651413e-06 miRNATAP -0.12125843130605 1.68450294089721e-05 NA NA NA hsa-miR-144-5p PAX7 -2.75914786146772 1.55794225315972e-50 2.03652915781352 2.5484159291376e-07 mirMAP -0.293374432189294 2.20181234377348e-05 NA NA NA hsa-miR-145-5p PAX7 -2.62703571936687 7.64402900188551e-88 2.03652915781352 2.5484159291376e-07 mirMAP -0.405651123505753 1.07184308208549e-05 NA NA NA hsa-miR-452-5p PAX9 -2.48486455572568 1.24430987974325e-33 1.50739706624376 4.51792242443721e-11 mirMAP -0.252211785432396 5.48995649421011e-12 NA NA NA hsa-miR-486-5p PAX9 -3.87258704301474 1.22658629378451e-80 1.50739706624376 4.51792242443721e-11 miRanda -0.27773805903138 1.02682654787091e-15 NA NA NA hsa-miR-21-5p PBRM1 2.32007501846389 3.08394781855554e-137 -0.507755737369169 3.6309092918926e-12 miRNAWalker2_validate -0.244774891680869 4.784902197849e-28 NA NA NA hsa-miR-378a-5p PBX1 -2.43173551693523 1.44932837789175e-68 0.383124547914576 0.000939101086871089 MirTarget -0.310953944699094 5.21683546394833e-35 NA NA NA hsa-miR-182-5p PC 2.36408084103818 2.60011457600281e-72 -1.12707513777182 1.09331095716712e-21 MirTarget;miRNATAP -0.209861985859817 1.48825420177817e-13 NA NA NA hsa-miR-96-5p PC 3.24596558166606 1.92296159041707e-98 -1.12707513777182 1.09331095716712e-21 TargetScan;miRNATAP -0.152169692816142 1.26381385482842e-10 NA NA NA hsa-miR-224-5p PCBD2 -2.22249420723892 1.07787949391113e-18 0.254893330287496 0.000606273909609041 mirMAP -0.11763017896128 2.61421070172109e-35 NA NA NA hsa-miR-429 PCBP3 2.84108892259147 3.88520896426515e-64 -1.58008314208775 8.70297843930998e-15 miRanda -0.270554893353108 3.00255224011288e-12 NA NA NA hsa-miR-182-5p PCDH10 2.36408084103818 2.60011457600281e-72 -0.589847783454892 0.0702331583145207 miRNATAP -0.208706082224234 0.00721747931977302 NA NA NA hsa-miR-200b-3p PCDH10 2.11744072703209 1.66710572104191e-43 -0.589847783454892 0.0702331583145207 MirTarget -0.26151206086216 0.000150819811898916 NA NA NA hsa-miR-200c-3p PCDH10 2.07038651806183 6.84613386286599e-51 -0.589847783454892 0.0702331583145207 MirTarget -0.288094659975668 0.000146644199276303 NA NA NA hsa-miR-224-5p PCDH10 -2.22249420723892 1.07787949391113e-18 -0.589847783454892 0.0702331583145207 MirTarget -0.143049698734046 0.000957362294977745 NA NA NA hsa-miR-429 PCDH10 2.84108892259147 3.88520896426515e-64 -0.589847783454892 0.0702331583145207 MirTarget;PITA;miRanda;miRNATAP -0.214323304512697 0.000509342423994845 NA NA NA hsa-miR-96-5p PCDH10 3.24596558166606 1.92296159041707e-98 -0.589847783454892 0.0702331583145207 TargetScan;miRNATAP -0.251066428086425 9.44636006257207e-05 NA NA NA hsa-miR-141-5p PCDH11X 2.38411349683216 4.56310582620282e-58 -3.35877977775092 4.73102650731164e-33 miRNATAP -0.463810571558445 6.60595595303293e-14 NA NA NA hsa-miR-375 PCDH11X 2.09893673049766 1.68351780396203e-16 -3.35877977775092 4.73102650731164e-33 miRanda -0.27506813316742 4.81205787289436e-13 NA NA NA hsa-miR-429 PCDH11X 2.84108892259147 3.88520896426515e-64 -3.35877977775092 4.73102650731164e-33 miRanda -0.407702797299551 8.02216615340814e-14 NA NA NA hsa-miR-96-5p PCDH11X 3.24596558166606 1.92296159041707e-98 -3.35877977775092 4.73102650731164e-33 MirTarget -0.562349990003733 1.54253655031863e-23 NA NA NA hsa-miR-182-5p PCDH18 2.36408084103818 2.60011457600281e-72 -2.07605586585207 1.98892381019284e-49 MirTarget;miRNATAP -0.451466745090325 1.90265685486725e-40 NA NA NA hsa-miR-375 PCDH18 2.09893673049766 1.68351780396203e-16 -2.07605586585207 1.98892381019284e-49 miRanda -0.159161684945795 2.10540486091919e-16 NA NA NA hsa-miR-429 PCDH18 2.84108892259147 3.88520896426515e-64 -2.07605586585207 1.98892381019284e-49 miRanda -0.389341229535552 3.13547862958386e-48 NA NA NA hsa-miR-96-5p PCDH18 3.24596558166606 1.92296159041707e-98 -2.07605586585207 1.98892381019284e-49 miRNATAP -0.447599080221521 7.73619455037215e-60 NA NA NA hsa-miR-183-5p PCDH19 2.95681814393872 1.09965777344285e-92 -2.01847089352803 5.92265974145112e-23 mirMAP -0.409209824159122 3.28707659052548e-21 NA NA NA hsa-miR-196a-5p PCDH19 2.33423717464504 3.646557504928e-18 -2.01847089352803 5.92265974145112e-23 miRNATAP -0.142894136734253 4.22450930789526e-08 NA NA NA hsa-miR-200b-3p PCDH19 2.11744072703209 1.66710572104191e-43 -2.01847089352803 5.92265974145112e-23 TargetScan -0.331795782186515 4.5797341350269e-14 NA NA NA hsa-miR-200c-3p PCDH19 2.07038651806183 6.84613386286599e-51 -2.01847089352803 5.92265974145112e-23 miRNATAP -0.465837102503143 2.07114735399684e-22 NA NA NA hsa-miR-21-3p PCDH19 2.17476065946878 5.15299442583591e-75 -2.01847089352803 5.92265974145112e-23 MirTarget -0.396481991708748 4.04443351135793e-13 NA NA NA hsa-miR-429 PCDH19 2.84108892259147 3.88520896426515e-64 -2.01847089352803 5.92265974145112e-23 miRNATAP -0.359548936822379 2.70645939266621e-20 NA NA NA hsa-miR-200b-3p PCDH7 2.11744072703209 1.66710572104191e-43 -0.38249739786875 0.0153349818675969 TargetScan -0.231512878559724 2.63345000116007e-12 NA NA NA hsa-miR-429 PCDH7 2.84108892259147 3.88520896426515e-64 -0.38249739786875 0.0153349818675969 PITA;miRanda;miRNATAP -0.192024251437259 8.86763419633496e-11 NA NA NA hsa-miR-182-5p PCDH8 2.36408084103818 2.60011457600281e-72 -0.710613114700064 0.0124551900105734 MirTarget;miRNATAP -0.248402824135605 0.000245035893159281 NA NA NA hsa-miR-141-3p PCDH9 2.99777540204168 1.26370498493024e-78 -3.83392224636774 3.81147875867783e-64 MirTarget;miRNATAP -0.681415894788408 3.41632346531745e-52 NA NA NA hsa-miR-200a-3p PCDH9 2.55218480823434 2.96135446816238e-51 -3.83392224636774 3.81147875867783e-64 MirTarget;miRNATAP -0.553621618862474 8.33652706345163e-35 NA NA NA hsa-miR-429 PCDH9 2.84108892259147 3.88520896426515e-64 -3.83392224636774 3.81147875867783e-64 miRanda -0.552956005678346 3.23226013860529e-35 NA NA NA hsa-miR-511-5p PCDHA1 -2.27545475897362 3.84085514050558e-36 0.582968338495724 0.0535923967250733 MirTarget -0.109987459231679 0.0458439856599451 NA NA NA hsa-miR-21-3p PCDHA13 2.17476065946878 5.15299442583591e-75 -1.0987684345798 0.000281861941402257 MirTarget -0.367034278438408 4.00910401394681e-06 NA NA NA hsa-miR-21-3p PCDHA2 2.17476065946878 5.15299442583591e-75 -0.15724638043861 0.477185785724542 MirTarget -0.177447520305776 0.00228825875177198 NA NA NA hsa-miR-21-3p PCDHA3 2.17476065946878 5.15299442583591e-75 -1.18085152890718 5.44135841042735e-07 MirTarget -0.340305310406252 4.16860634742874e-08 NA NA NA hsa-miR-21-3p PCDHA5 2.17476065946878 5.15299442583591e-75 -0.222745269079769 0.398554438578697 MirTarget -0.153107245286023 0.0275806352487629 NA NA NA hsa-miR-21-3p PCDHA6 2.17476065946878 5.15299442583591e-75 -0.89027374175424 0.00161859325987844 MirTarget -0.27411927132602 0.000228806624242229 NA NA NA hsa-miR-429 PCDHA6 2.84108892259147 3.88520896426515e-64 -0.89027374175424 0.00161859325987844 miRNATAP -0.167860501049046 0.00173268559798526 NA NA NA hsa-miR-21-3p PCDHA7 2.17476065946878 5.15299442583591e-75 -0.175344252385946 0.390055334305828 MirTarget -0.114177734253739 0.0335861142475034 NA NA NA hsa-miR-21-3p PCDHAC1 2.17476065946878 5.15299442583591e-75 -1.25077285730246 1.2646391890237e-08 MirTarget -0.199980647257354 0.000604072678782706 NA NA NA hsa-miR-429 PCDHB14 2.84108892259147 3.88520896426515e-64 -0.70455361930692 3.06049048439922e-09 miRanda -0.121713995409572 6.99841465881012e-08 NA NA NA hsa-miR-429 PCDHB15 2.84108892259147 3.88520896426515e-64 -1.36249552578113 3.47570259436051e-32 miRanda -0.248606723204557 9.49844293020556e-30 NA NA NA hsa-miR-429 PCDHB5 2.84108892259147 3.88520896426515e-64 -1.45440315134904 7.50291593314305e-16 miRanda -0.263834531986478 1.3982433677281e-14 NA NA NA hsa-miR-429 PCDHGA1 2.84108892259147 3.88520896426515e-64 -0.6298030997441 0.00114292801829591 miRNATAP -0.144365901167395 8.28963917041683e-05 NA NA NA hsa-miR-429 PCDHGA10 2.84108892259147 3.88520896426515e-64 -1.1032432713533 2.33889510866597e-07 miRNATAP -0.226310343931904 2.17218272873192e-08 NA NA NA hsa-miR-429 PCDHGA11 2.84108892259147 3.88520896426515e-64 -1.6839171718201 8.85649506729669e-26 miRanda;miRNATAP -0.261819124008976 1.72280266917394e-17 NA NA NA hsa-miR-429 PCDHGA12 2.84108892259147 3.88520896426515e-64 -1.21599251115806 1.44246526771226e-11 miRNATAP -0.266651736354612 4.38802519080711e-15 NA NA NA hsa-miR-429 PCDHGA2 2.84108892259147 3.88520896426515e-64 -2.53454953770495 2.5559414287724e-33 miRNATAP -0.398512153928414 8.26983990103378e-23 NA NA NA hsa-miR-429 PCDHGA3 2.84108892259147 3.88520896426515e-64 -2.34677567765991 1.85629227002049e-40 miRNATAP -0.407773499262196 1.19138921023197e-33 NA NA NA hsa-miR-429 PCDHGA4 2.84108892259147 3.88520896426515e-64 -1.78538346326217 1.53018321609373e-18 miRNATAP -0.309149340152759 1.35682168615046e-15 NA NA NA hsa-miR-429 PCDHGA5 2.84108892259147 3.88520896426515e-64 -1.89554832995795 1.92381404032939e-21 miRNATAP -0.362593898651483 8.57858488795495e-22 NA NA NA hsa-miR-429 PCDHGA6 2.84108892259147 3.88520896426515e-64 -1.8070193866698 6.08773636456156e-28 miRNATAP -0.302767364481763 7.8787640529016e-22 NA NA NA hsa-miR-429 PCDHGA7 2.84108892259147 3.88520896426515e-64 -1.46869412115925 1.73406418353035e-14 miRNATAP -0.2341612150372 1.43770377359549e-10 NA NA NA hsa-miR-429 PCDHGA9 2.84108892259147 3.88520896426515e-64 -2.01157276235327 1.56877482228631e-26 miRNATAP -0.381679681683065 1.52529723917705e-26 NA NA NA hsa-miR-429 PCDHGB2 2.84108892259147 3.88520896426515e-64 -1.22861675722792 2.2343583631542e-09 miRNATAP -0.253432297247953 7.29606506293254e-11 NA NA NA hsa-miR-429 PCDHGB3 2.84108892259147 3.88520896426515e-64 -1.53023004510997 1.53356403301585e-15 miRNATAP -0.238042744753675 8.13474108548008e-11 NA NA NA hsa-miR-429 PCDHGB4 2.84108892259147 3.88520896426515e-64 -1.52175481038299 2.33342214942491e-11 miRNATAP -0.226074087651771 1.92465595292539e-07 NA NA NA hsa-miR-429 PCDHGB5 2.84108892259147 3.88520896426515e-64 -1.64016711727275 7.89557206942268e-11 miRNATAP -0.284948145801776 2.81544799237092e-09 NA NA NA hsa-miR-429 PCDHGB6 2.84108892259147 3.88520896426515e-64 -2.09691325105411 3.30306462415709e-34 miRNATAP -0.369331008913677 2.26866010555628e-29 NA NA NA hsa-miR-429 PCDHGB7 2.84108892259147 3.88520896426515e-64 -2.37321964922838 3.39654061037756e-37 miRNATAP -0.417390409371619 8.79898993728115e-32 NA NA NA hsa-miR-429 PCDHGC3 2.84108892259147 3.88520896426515e-64 -0.699563778545607 2.57424088232569e-15 miRNATAP -0.145025577411275 3.77618585268548e-18 NA NA NA hsa-miR-429 PCDHGC4 2.84108892259147 3.88520896426515e-64 -0.802293590064656 7.53612120860297e-05 miRNATAP -0.104577424211694 0.00666376575112595 NA NA NA hsa-miR-429 PCDHGC5 2.84108892259147 3.88520896426515e-64 -0.437476733466256 0.0245321300385338 miRNATAP -0.163525518769652 8.59164901384341e-06 NA NA NA hsa-miR-141-3p PCGF5 2.99777540204168 1.26370498493024e-78 -0.885572387235352 3.41102487287495e-33 MirTarget -0.114564683868903 6.2908018056077e-15 NA NA NA hsa-miR-182-5p PCGF5 2.36408084103818 2.60011457600281e-72 -0.885572387235352 3.41102487287495e-33 miRNATAP -0.142243999070976 2.74153038537796e-15 NA NA NA hsa-miR-183-5p PCGF5 2.95681814393872 1.09965777344285e-92 -0.885572387235352 3.41102487287495e-33 MirTarget -0.143280376529201 1.41178486824138e-19 NA NA NA hsa-miR-21-3p PCGF5 2.17476065946878 5.15299442583591e-75 -0.885572387235352 3.41102487287495e-33 MirTarget -0.131990073767059 4.09543175680302e-11 NA NA NA hsa-miR-21-5p PCGF5 2.32007501846389 3.08394781855554e-137 -0.885572387235352 3.41102487287495e-33 mirMAP -0.282044434420571 1.02711226243984e-34 NA NA NA hsa-miR-429 PCGF5 2.84108892259147 3.88520896426515e-64 -0.885572387235352 3.41102487287495e-33 miRNATAP -0.114286698913215 1.34451804656186e-15 NA NA NA hsa-miR-96-5p PCGF5 3.24596558166606 1.92296159041707e-98 -0.885572387235352 3.41102487287495e-33 MirTarget;TargetScan;miRNATAP -0.152669622534506 3.93468310784182e-25 NA NA NA hsa-miR-21-3p PCMTD2 2.17476065946878 5.15299442583591e-75 -0.330131456699701 1.68770544462232e-05 MirTarget -0.111481845088061 3.04762814077465e-08 NA NA NA hsa-miR-182-5p PCOLCE2 2.36408084103818 2.60011457600281e-72 -5.34447065684793 3.25334281900878e-61 miRNAWalker2_validate -1.11108386331257 4.95592616347093e-45 NA NA NA hsa-miR-200b-3p PCSK2 2.11744072703209 1.66710572104191e-43 -1.42424996634036 3.40373694425593e-05 TargetScan -0.294748227645407 5.4496275666322e-05 NA NA NA hsa-miR-200c-3p PCSK2 2.07038651806183 6.84613386286599e-51 -1.42424996634036 3.40373694425593e-05 miRNATAP -0.389154981000866 1.20004504496534e-06 NA NA NA hsa-miR-429 PCSK2 2.84108892259147 3.88520896426515e-64 -1.42424996634036 3.40373694425593e-05 PITA;miRanda;miRNATAP -0.221824121108596 0.000683085972592221 NA NA NA hsa-miR-335-5p PCSK4 -2.61355235628987 2.6462884165886e-51 1.54372099522056 1.36462792815591e-13 miRNAWalker2_validate -0.155168832009237 7.76258914000915e-05 NA NA NA hsa-miR-200b-3p PCSK5 2.11744072703209 1.66710572104191e-43 -1.92996085102886 3.3455070654901e-31 TargetScan -0.460555630923708 8.7985776699295e-40 NA NA NA hsa-miR-375 PCSK5 2.09893673049766 1.68351780396203e-16 -1.92996085102886 3.3455070654901e-31 miRanda -0.164728066636985 2.25219376652025e-13 NA NA NA hsa-miR-96-5p PCSK5 3.24596558166606 1.92296159041707e-98 -1.92996085102886 3.3455070654901e-31 TargetScan -0.449115350001686 8.07630027557961e-44 NA NA NA hsa-miR-335-5p PCSK9 -2.61355235628987 2.6462884165886e-51 1.37805983825414 1.04473800539523e-08 miRNAWalker2_validate -0.232223878896774 2.29400383567847e-07 NA NA NA hsa-miR-429 PCYOX1 2.84108892259147 3.88520896426515e-64 -1.09884998986409 7.48295373511972e-39 miRNATAP -0.149891786957811 5.44099603169237e-20 NA NA NA hsa-miR-375 PCYT1B 2.09893673049766 1.68351780396203e-16 -1.38365830596984 9.36394456120861e-11 mirMAP -0.191753460610776 1.02219166212065e-11 NA NA NA hsa-miR-429 PCYT1B 2.84108892259147 3.88520896426515e-64 -1.38365830596984 9.36394456120861e-11 miRNATAP -0.171392243412788 2.6853955993072e-05 NA NA NA hsa-miR-139-5p PDCD10 -3.25846663863766 2.62018989415003e-112 0.460635383872706 1.13458966623475e-14 miRanda -0.130081546684898 4.20513891474583e-27 NA NA NA hsa-miR-21-5p PDCD4 2.32007501846389 3.08394781855554e-137 -0.110829364318222 0.352934989327702 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109773096535706 0.00312356894215013 17991735;19308091;26169933;22547075;22086602;26212010;23052036;19633292;25566594;25575817;25316501;22072622;22267128;22322403;19836969;22212233;23604124;25520758;19682430;23272133;25477028;26252635;25994220;25991676;22747440;23827854;23824073;24865582;24902663;24888238;24149370;20978511;22689922;27355932;24331411;20372781;23558936;23201752;20815812;17968323;25310697;21842656;23567619;20581857;23888942;23548551;19013014;21685938;26142886;24472409;25973032;26418978;24659669;25543482;25543261;23904372;27725205;23564788;25400316;26150475;21546206;19509156;27035745;22353043;21412018;19276261;21330826;26864640;22335905;21636706 Programmed cell death 4 PDCD4 is an important functional target of the microRNA miR 21 in breast cancer cells;We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion;The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase upregulate the expression of Programmed Cell Death Protein 4 PDCD4 and thus active the caspase-3 apoptosis pathway;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;The effects were accompanied by up-regulation of tumor suppressor PDCD4 a known miR-21 target; as well as up-regulation of cofilin and profilin two key proteins involved in actin polymerization and cytoskeleton maintenance as a consequence of miR-182 down-regulation;Increased levels of miR-21 in turn downregulate the expression of the metastasis-suppressor protein programmed cell death 4 PDCD4 a validated miR-21 target;Fenhexamid and fludioxonil stimulated miR-21 expression in a concentration-dependent manner and reduced the expression of miR-21 target Pdcd4 protein; Antisense to miR-21 blocked the increase in Pdcd4 protein by fenhexamid and fludioxonil;This process leads to microRNA-21 miR-21 production and a tumor suppressor protein e.g PDCD4 program cell death 4 reduction; Transfection of MCF-7 cells with PKCepsilon or Nanog-specific small interfering RNAs effectively blocks HA-mediated PKCepsilon-Nanog signaling events abrogates miR-21 production and increases PDCD4 expression/eIF4A binding;Through dual-luciferase method it was verified that PDCD4 and PDCD10 were real target genes of miR-21 and miR-200c respectively;We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells;MTCs were consistently associated with miR-21 up-regulation P < .0016 and featured significant PDCD4 nuclear down-regulation; An inverse correlation emerged between miR-21 overexpression and PDCD4 down-regulation P = .0013; This study showed in MTCs that miR-21 regulates PDCD4 expression and also that the miR-21/PDCD4 pathway correlates with clinicopathological variables and prognosis;Although microRNA-21 miR-21 is emerging as an oncogene and has been shown to target several tumor suppressor genes including programmed cell death 4 PDCD4 its precise mechanism of action on cancer stem cells CSCs is unclear; Herein we report that FOLFOX-resistant HCT-116 and HT-29 cells that are enriched in CSCs show a 3- to 7-fold upregulation of pre- and mature miR-21 and downregulation of PDCD4; Likewise overexpression of miR-21 in HCT-116 cells achieved through stable transfection led to the downregulation of PDCD4 and transforming growth factor beta receptor 2 TGFβR2;Prognostic significance of PDCD4 expression and association with microRNA 21 in each Dukes' stage of colorectal cancer patients; Furthermore relationships between the PDCD4 mRNA and microRNA-21 miR-21 were evaluated; The PDCD4 mRNA was investigated by the quantitative real-time RT-PCR method and miR-21 was examined by TaqMan microRNA assays; Significant inverse correlations were demonstrated between PDCD4 and miR-21;miR 21 promotes migration and invasion by the miR 21 PDCD4 AP 1 feedback loop in human hepatocellular carcinoma; The expression level of miR-21 was inversely correlated with the protein expression level of a previously identified target gene programmed cell death 4 PDCD4;This short review will focus on our recent finding that the microRNA miR-21 posttranscriptionally regulates Pdcd4 as well as invasion intravasation and metastasis;PDCD4 expression inversely correlated with miR 21 levels in gastric cancers;HBx mediated miR 21 upregulation represses tumor suppressor function of PDCD4 in hepatocellular carcinoma; HBx downregulates PDCD4 expression at least partially through miR-21; Taken together this study reported for the first time that HBx downregulates PDCD4 and upregulates miR-21 expression; The deregulation of PDCD4 by HBx through miR-21 represents a potential novel mechanism of the downregulation of PDCD4 in HBV-related HCC and provides new insights into HCC development;MicroRNA 21 Down regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma; MicroRNA-21 miR-21 possesses the oncogenic potential to target several tumor suppressor genes including PDCD4 and regulates tumor progression and metastasis; However the mechanism of how miR-21 regulates PDCD4 is poorly understood in RB; Using the TargetScan program we identified a list of potential target genes of these miRNAs of which PDCD4 is one the targets of miR-21; In this study we focused on the regulatory mechanism of miR-21 on PDCD4 in RB; We demonstrated an inverse correlation between miR-21 and PDCD4 expression in Weri-Rb1 and Y79 cells; These data suggest that miR-21 down-regulates Rb1 by targeting PDCD4 tumor suppressor;MicroRNA 21 promotes cell proliferation and down regulates the expression of programmed cell death 4 PDCD4 in HeLa cervical carcinoma cells; In this study we found that the inhibition of miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation and up-regulated the expression of the tumor suppressor gene PDCD4;Additionally resveratrol increased the expression of tumor suppressors PDCD4 and maspin which are negatively regulated by miR-21; Short interfering si RNA against PDCD4 attenuated resveratrol's effect on prostate cancer cells and similar effects were observed following over expression of miR-21 with pre-miR-21 oligonucleotides; MiR-21 expression in these cells appeared to be dependent on Akt as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression; These tumor- and metastatic-suppressive effects of resveratrol were associated with reduced miR-21 and pAkt and elevated PDCD4 levels;The expression of miR-21 and PDCD4 mRNA in transfected cells was quantified by real-time polymerase chain reaction and the expression of PDCD4 protein by Western blot; Cell proliferation apoptosis migration and invasion assays were performed to determine the biological effects of miR-21 expression and PDCD4 inhibition; Co-transfection of miR-21-sponge with PDCD4 siRNA upregulated miR-21 expression in these cells; PDCD4 mRNA and protein levels were increased 2.14-fold and 2.16-fold respectively following inhibition of miR-21 expression; Depletion of PDCD4 by siRNA transfection reversed the reduction of cell proliferation migration and invasion induced by inhibition of miR-21 in A549 cells; It indicates that miR-21 is highly expressed in patients with NSCLC and inhibition of miR-21 expression reduces proliferation migration and invasion of A549 cells by upregulating PDCD4 expression; Modulation of miR-21 or PDCD4 expression may provide a potentially novel therapeutic approach for NSCLC;IL 6 Inhibits the Targeted Modulation of PDCD4 by miR 21 in Prostate Cancer; In this study we evaluated the role of IL-6 in PDCD4 gene expression and how the microRNA miR-21 regulates this process in prostate cancer cell lines PC-3 and LNCaP; The expression of PDCD4 was inhibited by IL-6 but this effect was weakened in cell lines with low expression of miR-21; These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 miR-21 and PDCD4;Furthermore the absence of miR-21 increased the expression of its target gene PDCD4 and subsequently modulated nuclear factor NF-κB activation;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;We also analyzed the immunohistochemical expression of PDCD4 an miR-21 gene target; PDCD4 expression was significantly downregulated in MTC samples consistent with miR-21 upregulation;Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA 21 mediated programmed cell death 4 PDCD4 expression; Further AR inhibition also increased PDCD4 a putative target of miR-21 in human colon cancer cells; Collectively these results indicate that AR inhibition prevents growth factor-induced colon cancer growth by down-regulating miR-21 expression and increasing PDCD4 levels through the reactive oxygen species ROS/AMPK/mTOR/AP1/4E-BP1 pathway;Berberine could inhibit miR-21 expression and function in ovarian cancer as shown by an enhancement of its target PDCD4 an important tumor suppressor in ovarian cancer;Overexpression of miR-21 in cisplatin sensitive cells decreased PDCD4 levels and increased cell proliferation;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation proliferation and metastasis in renal cell carcinoma; MiR-21 induces neoplastic transformation cell proliferation and metastasis and downregulates programmed cell death4 PDCD4 in some cancers; The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma RCC; The expression levels of PDCD4 protein and mRNA and miR-21 were examined by Western blot analysis and by qRT-PCR and luciferase reporter assays; MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis but also post-transcriptionally downregulated PDCD4 protein expression; PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer;Programmed cell death 4 PDCD4 is a tumor suppressor gene whose expression is directly controlled by microRNA-21 miR-21; This PDCD4 and miR-21 inverse expression was also noted in cells and exosomes from OSC peritoneal effusions compared with nonneoplastic effusions; PDCD4 and miR-21 are involved in OSC oncogenesis;Finally in a subgroup of tumor specimens ROC curve analysis performed on quantitative PCR data sets for miR-21 ITGβ4 and PDCD4 shows that the combination of high miR-21 with low ITGβ4 and PDCD4 expression is able to predict presence of metastasis; In conclusion miR-21 is a key player in oncogenic EMT its overexpression is controlled by the cooperation of genetic and epigenetic alterations and its levels along with ITGβ4 and PDCD4 expression could be exploited as a prognostic tool for CRC metastasis;Transfection of anti-miR-21 rendered HCC cells sensitive to IFN-α/5-FU and such sensitivity was weakened by transfection of siRNAs of target molecules PETN and PDCD4 miR-21 expression in clinical HCC specimens was significantly associated with the clinical response to the IFN-α/5-FU combination therapy and survival rate;In ZD esophagus and tongue oncogenic miR-31 and miR-21 overexpression was accompanied by down-regulation of their respective tumor-suppressor targets PPP2R2A and PDCD4;Due to inhibition of miR-21 expression of the programed cell death 4 PDCD4 gene was promoted in tumors resulting in the induction of apoptosis of tumor cells;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;Clinicopathological and prognostic significance of PDCD4 and microRNA 21 in human gastric cancer; Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 PDCD4 is downregulated in several human solid cancer types and is suppressed by microRNA-21 miR-21; The objectives of this study were: i to establish the clinicopathological and prognostic significance of PDCD4 mRNA and ii to elucidate any correlation between PDCD4 mRNA and miR-21 in gastric cancer; We also performed an association study comparing PDCD4 mRNA and miR-21 in eight cell lines and 49 gastric cancers; An inverse correlation between PDCD4 mRNA and miR-21 was found in gastric cancer; Furthermore our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter and induced the expression of the tumour suppressor Pdcd4 programmed cell death protein 4 which is a target of miR-21; Taken together this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1 suppresses cell proliferation tumour growth invasion and in vivo metastasis and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion intravasation and metastasis in colorectal cancer; This is the first study to show that Pdcd4 is negatively regulated by miR-21;Inflammation and MiR 21 pathways functionally interact to downregulate PDCD4 in colorectal cancer; These findings indicate that miR-21 is a component of the COX-2 inflammation pathway and that this pathway promotes worsening of disease stage in colorectal cancer by inducing accumulation of PGE2 and increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Interestingly NVP-LDE-225 induced PDCD4 and apoptosis and inhibited cell viability by suppressing miR-21;PDCD4 a direct target gene of miR-21 could mediate chemoresistance to docetaxel in PC3 cells;Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR 21; The expression of miR-21 and PDCD4 was highly correlated with the degree of differentiation tumor staging local lymphatic node metastasis and remote metastasis; In addition the relative expression of PDCD4 was negatively correlated with miR-21; Thus we conclude that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;MicroRNA 21 down regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G; Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G A172 U87 and U251; Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis;Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events abrogates miR-21 production and increases PDCD4 expression;Programmed cell death 4 PDCD4 is critical in mediating apoptosis in GBM and is downregulated by miR-21 which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4; This review will focus on the roles of miRNAs family members particularly miR-21 and its target gene PDCD4 in tumors like glioblastoma and new targeting strategies as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies;Using Western blot analysis miR-21 knockdown enhanced the expression of tumor suppressor PDCD4 and attenuated apoptosis inhibitor c-IAP2;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;METHODS 3-45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide MTT assay was used to determine the effect of 5-FU on the viability of RKO cells with knockout of miR-21 or high expression of PDCD4;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;In this study we analyzed the expression of miR-21 and of its target PDCD4 Programmed Cell Death 4 during normal hematopoietic differentiation and in AMLs;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated;The expression of programmed cell death-4 PDCD4 was increased by I3C and reduced by miR-21 transfection; Such enhanced chemosensitivity might be explained by the increased expression of PDCD4 which is a downstream target which miR-21 negatively regulates;It has been reported that miR-21 was upregulated in most malignant cancers the proposed mechanism of which was through suppressing expression of programmed cell death 4 PDCD4; In present study it is firstly reported that miR-21 was upregulated in Kazakh's ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization ISH and luciferase reporter approach;To measure levels of microRNA miR-21 and its target gene programmed cell death 4 PDCD4 in samples of human cutaneous malignant melanoma and normal non-malignant control skin; Relative levels of miR-21 and PDCD4 mRNA were measured using a quantitative real-time reverse transcription-polymerase chain reaction; Compared with normal skin samples the relative level of miR-21 was significantly higher and the relative level of PDCD4 mRNA was significantly lower in the melanoma specimens; A significant negative correlation between PDCD4 mRNA and miR-21 was demonstrated in malignant melanoma r = -0.602; Elevated miR-21 and reduced PDCD4 mRNA levels were both significantly correlated with increased tumour size a higher Clark classification level and the presence of lymph node metastases in malignant melanoma; These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future;MicroRNA 21 and PDCD4 expression in colorectal cancer; Studies have shown that miR-21 exerts its oncogenic activity by targeting the PDCD4 tumour suppressor 3'-UTR; The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer; A cohort of 48 colorectal tumours 61 normal tissues and 7 polyps were profiled for miR-21 and PDCD4 gene expression; A significant inverse relationship between miR-21 and PDCD4 gene expression p < 0.001 was identified by RT-qPCR; In addition significant reduction of PDCD4 p < 0.001 expression and reciprocal upregulation of miR-21 p = 0.005 in a progressive manner from tumour-polyp-normal mucosae was identified; This study demonstrates the inverse relationship between miR-21 and PDCD4 thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation;Expression patterns of miR-21 RNA and its target tumor suppressor protein PDCD4 were mutually exclusive;Exosome shuttling microRNA 21 promotes cell migration and invasion targeting PDCD4 in esophageal cancer;The expression of programmed cell death 4 PDCD4 which is a miR-21 targeting apoptotic gene has also been enhanced by UA; And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;The aim of this study was a to determine a role of microRNA-21 in esophageal squamous cell carcinoma and b to elucidate the regulation of the programmed cell death 4 PDCD4 gene by microRNA-21; In addition the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation; The PDCD4 protein levels in esophageal squamous cell carcinoma cells have an inverse correlation with microRNA-21 expression; MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma;Maspin Pdcd4 and miR-21 expressions were evaluated by a real-time polymerase chain reaction in 20 endometrial cancer and 10 normal endometrium samples; Comparison between IA and more advanced International Federation of Gynecology and Obstetrics stages of endometrial cancer in regard to expression levels of maspin Pdcd4 and miR-21 did not reveal any significant differences;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Sequence prediction and gene expression regulation assays showed that miR-21 could reversely regulate the expression of PDCD4 P < 0.01; Suppression of miR-21 expression is associated with an elevation of Pdcd4 resulting in a significant reduction of proliferation and the apoptosis rate 2.6% was increased to 10.9%; Moreover the anti-proliferation and pro-apoptotic effect by miR-21 suppression could be reversed by PDCD4 knock down;Downregulation of Pdcd4 by mir 21 facilitates glioblastoma proliferation in vivo; We demonstrate that downregulation of mir-21 in glioblastoma-derived cell lines results in increased expression of its target programmed cell death 4 Pdcd4 a known tumor-suppressor gene; In addition our data indicate that either downregulation of mir-21 or overexpression of its target Pdcd4 in glioblastoma-derived cell lines leads to decreased proliferation increased apoptosis and decreased colony formation in soft agar; Using a glioblastoma xenograft model in immune-deficient nude mice we observe that glioblastoma-derived cell lines in which mir-21 levels are downregulated or Pdcd4 is over-expressed exhibit decreased tumor formation and growth; These critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir-21 expression in glioblastoma can attribute to tumorigenesis--namely inhibition of Pdcd4 and its tumor-suppressive functions ;;;;;metastasis;;;;;worse prognosis;;staging;;metastasis;;;metastasis;progression;;;;;;poor survival;;;;;metastasis;;metastasis;poor survival;drug resistance;;;drug resistance;;progression;;metastasis;metastasis;staging;;;drug resistance;staging;metastasis;differentiation;tumorigenesis;;;;drug resistance;;;;;;differentiation;drug resistance;;;malignant trasformation;malignant trasformation;metastasis;progression;;cell migration;;;;staging;drug resistance;;tumorigenesis breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;chronic myeloid leukemia;thyroid cancer;colon cancer;colorectal cancer;liver cancer;colon cancer;gastric cancer;liver cancer;retinoblastoma;cervical and endocervical cancer;prostate cancer;lung squamous cell cancer;prostate cancer;colorectal cancer;glioblastoma;thyroid cancer;colon cancer;ovarian cancer;ovarian cancer;kidney renal cell cancer;ovarian cancer;colorectal cancer;liver cancer;esophageal cancer;glioblastoma;lung squamous cell cancer;gastric cancer;kidney renal cell cancer;glioblastoma;colorectal cancer;colorectal cancer;colorectal cancer;lung cancer;prostate cancer;prostate cancer;gastric cancer;B cell lymphoma;glioblastoma;head and neck cancer;glioblastoma;ovarian cancer;liver cancer;colon cancer;gastric cancer;B cell lymphoma;acute myeloid leukemia;glioblastoma;prostate cancer;pancreatic cancer;esophageal cancer;melanoma;colorectal cancer;colorectal cancer;esophageal cancer;glioblastoma;colorectal cancer;esophageal cancer;endometrial cancer;pancreatic cancer;lung squamous cell cancer;glioblastoma hsa-miR-200b-3p PDE10A 2.11744072703209 1.66710572104191e-43 -0.585329690276131 3.9584796407678e-05 mirMAP -0.229661031753558 1.50901534886657e-14 NA NA NA hsa-miR-200c-3p PDE10A 2.07038651806183 6.84613386286599e-51 -0.585329690276131 3.9584796407678e-05 mirMAP -0.261178672318255 1.72791535704395e-15 NA NA NA hsa-miR-429 PDE10A 2.84108892259147 3.88520896426515e-64 -0.585329690276131 3.9584796407678e-05 mirMAP -0.17815670771441 2.96003912336741e-11 NA NA NA hsa-miR-429 PDE11A 2.84108892259147 3.88520896426515e-64 -3.02201464478318 4.1418436019978e-49 miRanda;miRNATAP -0.513448952565414 9.96708355982443e-39 NA NA NA hsa-miR-141-3p PDE1C 2.99777540204168 1.26370498493024e-78 -3.9471279332945 1.74355712680188e-60 mirMAP -0.513217876946579 1.18637564792511e-25 NA NA NA hsa-miR-182-5p PDE1C 2.36408084103818 2.60011457600281e-72 -3.9471279332945 1.74355712680188e-60 mirMAP -0.654110959260233 9.65547036110923e-28 NA NA NA hsa-miR-200a-3p PDE1C 2.55218480823434 2.96135446816238e-51 -3.9471279332945 1.74355712680188e-60 mirMAP -0.390892494128905 1.04247738122523e-15 NA NA NA hsa-miR-21-5p PDE1C 2.32007501846389 3.08394781855554e-137 -3.9471279332945 1.74355712680188e-60 mirMAP -0.88293003236443 1.44419962390607e-29 NA NA NA hsa-miR-183-5p PDE3A 2.95681814393872 1.09965777344285e-92 -1.62642968102244 1.38166545940769e-14 miRNATAP -0.30018510306533 2.04225535454455e-11 NA NA NA hsa-miR-21-3p PDE3A 2.17476065946878 5.15299442583591e-75 -1.62642968102244 1.38166545940769e-14 mirMAP -0.267374821113735 2.05291733574154e-06 NA NA NA hsa-miR-182-5p PDE4D 2.36408084103818 2.60011457600281e-72 -0.515867337472647 0.000105517780035465 mirMAP -0.107354293677951 0.000728831894804869 NA NA NA hsa-miR-200b-3p PDE4D 2.11744072703209 1.66710572104191e-43 -0.515867337472647 0.000105517780035465 mirMAP -0.19058210162814 9.9443247546046e-12 NA NA NA hsa-miR-200c-3p PDE4D 2.07038651806183 6.84613386286599e-51 -0.515867337472647 0.000105517780035465 mirMAP -0.177507320297067 9.29083994916719e-09 NA NA NA hsa-miR-429 PDE4D 2.84108892259147 3.88520896426515e-64 -0.515867337472647 0.000105517780035465 mirMAP;miRNATAP -0.141557550532844 1.71947616760673e-08 NA NA NA hsa-miR-96-5p PDE4D 3.24596558166606 1.92296159041707e-98 -0.515867337472647 0.000105517780035465 TargetScan -0.111239797722618 2.36621778337163e-05 NA NA NA hsa-miR-200c-3p PDE5A 2.07038651806183 6.84613386286599e-51 -1.75867073177592 2.55136534038232e-29 miRNATAP -0.272409753840994 2.91975746364297e-13 NA NA NA hsa-miR-429 PDE5A 2.84108892259147 3.88520896426515e-64 -1.75867073177592 2.55136534038232e-29 miRanda;miRNATAP -0.265716951471396 1.04817886317241e-18 NA NA NA hsa-miR-139-5p PDE7A -3.25846663863766 2.62018989415003e-112 0.291310531337332 0.00284831214739663 miRanda -0.160343361243262 5.24941586975722e-16 NA NA NA hsa-miR-182-5p PDE7B 2.36408084103818 2.60011457600281e-72 -1.8192986932678 4.14918988039866e-48 miRNATAP -0.343381470651255 2.28800744069341e-29 NA NA NA hsa-miR-200b-3p PDE7B 2.11744072703209 1.66710572104191e-43 -1.8192986932678 4.14918988039866e-48 TargetScan -0.348600223874175 1.44238454289598e-38 NA NA NA hsa-miR-200c-3p PDE7B 2.07038651806183 6.84613386286599e-51 -1.8192986932678 4.14918988039866e-48 miRNATAP -0.434760282901556 1.28232495346798e-50 NA NA NA hsa-miR-429 PDE7B 2.84108892259147 3.88520896426515e-64 -1.8192986932678 4.14918988039866e-48 miRNATAP -0.325624164780697 1.89521714507522e-42 NA NA NA hsa-miR-96-5p PDE7B 3.24596558166606 1.92296159041707e-98 -1.8192986932678 4.14918988039866e-48 TargetScan;miRNATAP -0.360377160287302 3.43578681147914e-48 NA NA NA hsa-miR-96-5p PDE8B 3.24596558166606 1.92296159041707e-98 -2.55138134636632 4.50317713785618e-32 MirTarget;TargetScan;miRNATAP -0.414259314962958 1.54396176074628e-21 NA NA NA hsa-miR-21-5p PDGFD 2.32007501846389 3.08394781855554e-137 -2.17788738091168 7.06207148591019e-60 miRNAWalker2_validate -0.58246612445279 1.38968424696146e-42 NA NA NA hsa-miR-141-3p PDGFRA 2.99777540204168 1.26370498493024e-78 -1.84169721584144 2.50038285124215e-31 MirTarget -0.465703815469129 7.78017639246501e-55 NA NA NA hsa-miR-182-5p PDGFRA 2.36408084103818 2.60011457600281e-72 -1.84169721584144 2.50038285124215e-31 miRNATAP -0.488133036134936 5.32981617385656e-39 NA NA NA hsa-miR-200a-3p PDGFRA 2.55218480823434 2.96135446816238e-51 -1.84169721584144 2.50038285124215e-31 MirTarget -0.404359885272289 5.76229938736958e-42 NA NA NA hsa-miR-429 PDGFRA 2.84108892259147 3.88520896426515e-64 -1.84169721584144 2.50038285124215e-31 miRanda;miRNATAP -0.373691764862624 4.97896969778458e-36 NA NA NA hsa-miR-96-5p PDGFRA 3.24596558166606 1.92296159041707e-98 -1.84169721584144 2.50038285124215e-31 TargetScan;miRNATAP -0.477431215706839 8.10828261241382e-56 NA NA NA hsa-miR-335-5p PDIA4 -2.61355235628987 2.6462884165886e-51 1.18653667878445 1.48043523911924e-55 miRNAWalker2_validate -0.151140804867557 4.4370292471929e-25 NA NA NA hsa-miR-452-5p PDIK1L -2.48486455572568 1.24430987974325e-33 0.465396504296977 1.19867689993514e-10 MirTarget;mirMAP -0.138107454590912 4.80951516427244e-35 NA NA NA hsa-miR-200a-3p PDK2 2.55218480823434 2.96135446816238e-51 -0.829357718034116 1.58708871081625e-18 mirMAP -0.112275719100424 7.29954656187263e-10 NA NA NA hsa-miR-429 PDK4 2.84108892259147 3.88520896426515e-64 -3.89935179730226 5.03724845925338e-73 miRanda -0.567070392199625 2.867364355147e-40 NA NA NA hsa-miR-335-5p PDLIM2 -2.61355235628987 2.6462884165886e-51 0.406376624788563 1.36501396675266e-05 mirMAP -0.126684833861828 1.70574111430542e-13 NA NA NA hsa-miR-21-3p PDP2 2.17476065946878 5.15299442583591e-75 -1.43780359723012 2.43286959032583e-40 MirTarget -0.179030205413605 1.61105524104193e-09 NA NA NA hsa-miR-182-5p PDPN 2.36408084103818 2.60011457600281e-72 -0.59681583742594 1.49629082901481e-05 MirTarget -0.268685243467488 1.13922429281011e-16 NA NA NA hsa-miR-21-3p PDPR 2.17476065946878 5.15299442583591e-75 -1.06032682095171 5.70122296228123e-20 mirMAP -0.127825507200259 4.05293235940819e-05 NA NA NA hsa-miR-139-5p PDXDC1 -3.25846663863766 2.62018989415003e-112 0.867679818835133 1.64124821154065e-33 miRanda -0.163104602403302 7.84726409746754e-28 NA NA NA hsa-miR-145-5p PDXDC1 -2.62703571936687 7.64402900188551e-88 0.867679818835133 1.64124821154065e-33 MirTarget -0.136398263430833 1.55224555909963e-15 NA NA NA hsa-miR-10b-5p PDXK -2.10996264627796 7.36811595736367e-72 -0.184719599842688 0.0324170441610667 mirMAP -0.12078066043064 1.27468611718506e-07 NA NA NA hsa-miR-141-3p PDZD2 2.99777540204168 1.26370498493024e-78 -2.76417153731067 5.68349864068644e-65 TargetScan -0.521797399474431 1.49797675214627e-60 NA NA NA hsa-miR-429 PDZD2 2.84108892259147 3.88520896426515e-64 -2.76417153731067 5.68349864068644e-65 miRanda -0.42791236864364 2.17131692709634e-41 NA NA NA hsa-miR-182-5p PDZD4 2.36408084103818 2.60011457600281e-72 -1.41293810393522 1.04865872605217e-13 MirTarget;miRNATAP -0.223702843647876 1.02433342904709e-06 NA NA NA hsa-miR-210-3p PDZD4 2.38367203491819 3.73261999106754e-22 -1.41293810393522 1.04865872605217e-13 MirTarget -0.251516726449508 4.9047621783015e-23 NA NA NA hsa-miR-429 PDZD4 2.84108892259147 3.88520896426515e-64 -1.41293810393522 1.04865872605217e-13 miRNATAP -0.204422981718846 1.79254538644662e-08 NA NA NA hsa-miR-96-5p PDZD8 3.24596558166606 1.92296159041707e-98 -0.691667053332502 1.30168468516457e-09 TargetScan -0.103843829206595 4.62882987932403e-06 NA NA NA hsa-miR-182-5p PDZRN4 2.36408084103818 2.60011457600281e-72 -2.16472105918031 2.28933730450947e-17 miRNATAP -0.36166479699917 4.36345088043808e-09 NA NA NA hsa-miR-96-5p PDZRN4 3.24596558166606 1.92296159041707e-98 -2.16472105918031 2.28933730450947e-17 miRNATAP -0.447150758349519 8.00572404600631e-19 NA NA NA hsa-miR-429 PECR 2.84108892259147 3.88520896426515e-64 -0.975574428432032 2.01591927100949e-21 miRanda -0.169355084746479 4.5349797487287e-18 NA NA NA hsa-miR-375 PEG10 2.09893673049766 1.68351780396203e-16 -0.95352146824468 0.00369200350510654 mirMAP -0.26000826616548 1.52346728510598e-09 NA NA NA hsa-miR-141-3p PEG3 2.99777540204168 1.26370498493024e-78 -1.76855555357171 1.41302613452224e-11 TargetScan -0.245831360280799 1.65786809256862e-06 NA NA NA hsa-miR-21-5p PELI1 2.32007501846389 3.08394781855554e-137 -1.27728919647403 2.35082397139246e-33 miRNAWalker2_validate;MirTarget;miRNATAP -0.349049524751964 1.76483309884008e-25 NA NA NA hsa-miR-200a-3p PELI2 2.55218480823434 2.96135446816238e-51 -2.1370288071573 1.71637344970085e-56 mirMAP -0.313508299910822 4.55908828462781e-32 NA NA NA hsa-miR-429 PELI2 2.84108892259147 3.88520896426515e-64 -2.1370288071573 1.71637344970085e-56 miRanda;miRNATAP -0.343151454818121 2.74867390095289e-39 NA NA NA hsa-miR-429 PENK 2.84108892259147 3.88520896426515e-64 -3.86605725361397 1.18837424026093e-41 miRanda;miRNATAP -0.574662736412717 3.54270221443008e-25 NA NA NA hsa-miR-429 PER1 2.84108892259147 3.88520896426515e-64 -2.12680756147138 7.01044041706429e-54 miRNATAP -0.275804209817926 2.79830382147511e-24 NA NA NA hsa-miR-21-5p PER2 2.32007501846389 3.08394781855554e-137 -1.21999479237138 5.23969354437314e-42 MirTarget -0.357383948326546 8.76797882197739e-37 NA NA NA hsa-miR-21-5p PER3 2.32007501846389 3.08394781855554e-137 -1.22424368381498 2.80442230784446e-27 miRNAWalker2_validate -0.427279087231266 2.59821833454111e-34 NA NA NA hsa-miR-21-5p PEX5L 2.32007501846389 3.08394781855554e-137 -0.0367678899809591 0.889139447396266 mirMAP -0.42348748755714 2.1841515323527e-07 NA NA NA hsa-miR-139-5p PFDN6 -3.25846663863766 2.62018989415003e-112 1.18053820623287 1.04677794699226e-37 miRanda;miRNATAP -0.229106030220295 2.71082784910468e-33 NA NA NA hsa-miR-139-5p PFKFB2 -3.25846663863766 2.62018989415003e-112 0.220155974920166 0.0529312498053296 miRanda -0.1050129786477 6.73812094713614e-06 NA NA NA hsa-miR-429 PFKFB3 2.84108892259147 3.88520896426515e-64 -1.79848514813105 5.16090350453096e-45 miRNATAP -0.232172915666766 1.69598903904671e-20 NA NA NA hsa-miR-335-5p PFKFB4 -2.61355235628987 2.6462884165886e-51 1.46356567497396 5.553830008223e-57 miRNAWalker2_validate -0.188054847943577 4.51655311687061e-26 NA NA NA hsa-miR-139-5p PFN2 -3.25846663863766 2.62018989415003e-112 0.388809973780238 0.00142879654721462 MirTarget;PITA;miRanda -0.172948171730637 3.40038209204324e-12 NA NA NA hsa-miR-182-5p PGAP1 2.36408084103818 2.60011457600281e-72 -1.31559839003994 2.62464485048632e-27 mirMAP;miRNATAP -0.209003635863954 1.55743338137739e-12 NA NA NA hsa-miR-200b-3p PGAP1 2.11744072703209 1.66710572104191e-43 -1.31559839003994 2.62464485048632e-27 mirMAP -0.211297291563601 7.38128913714327e-16 NA NA NA hsa-miR-429 PGAP1 2.84108892259147 3.88520896426515e-64 -1.31559839003994 2.62464485048632e-27 miRanda -0.22031967587682 2.42690158575813e-21 NA NA NA hsa-miR-96-5p PGAP1 3.24596558166606 1.92296159041707e-98 -1.31559839003994 2.62464485048632e-27 TargetScan;miRNATAP -0.215690381206679 7.55400822667588e-19 NA NA NA hsa-miR-139-5p PGM2L1 -3.25846663863766 2.62018989415003e-112 0.401515087346938 0.000741367585849094 PITA -0.117647248285931 1.48430178367921e-06 NA NA NA hsa-miR-429 PGM5 2.84108892259147 3.88520896426515e-64 -3.16536779857635 1.67228281373737e-61 miRanda -0.536829136798322 7.08834957821891e-48 NA NA NA hsa-miR-21-3p PGPEP1 2.17476065946878 5.15299442583591e-75 -0.27819104436342 0.00258648143907623 mirMAP -0.236578706196609 1.69886176023651e-23 NA NA NA hsa-miR-224-5p PGPEP1 -2.22249420723892 1.07787949391113e-18 -0.27819104436342 0.00258648143907623 mirMAP -0.122718217018104 9.31681101944436e-25 NA NA NA hsa-miR-378a-5p PGPEP1 -2.43173551693523 1.44932837789175e-68 -0.27819104436342 0.00258648143907623 mirMAP -0.16411409044682 1.55526564273194e-15 NA NA NA hsa-miR-452-5p PGR -2.48486455572568 1.24430987974325e-33 -1.22463197074196 0.000985194689617734 mirMAP -0.57638681638652 2.82946527475521e-23 NA NA NA hsa-miR-21-5p PGRMC2 2.32007501846389 3.08394781855554e-137 -0.296182001993629 1.14551491241792e-05 miRNAWalker2_validate -0.166401308644768 1.0800195721174e-15 NA NA NA hsa-miR-183-5p PHACTR1 2.95681814393872 1.09965777344285e-92 -0.392699948171172 0.00296514186466325 mirMAP -0.135475025347367 1.06394253875791e-06 NA NA NA hsa-miR-429 PHACTR1 2.84108892259147 3.88520896426515e-64 -0.392699948171172 0.00296514186466325 mirMAP -0.107373739550927 1.73933414686242e-05 NA NA NA hsa-miR-141-5p PHACTR2 2.38411349683216 4.56310582620282e-58 -1.0916982358773 4.3094820433717e-28 mirMAP -0.185767397954203 9.3443554301317e-18 NA NA NA hsa-miR-182-5p PHACTR2 2.36408084103818 2.60011457600281e-72 -1.0916982358773 4.3094820433717e-28 mirMAP -0.221160155738631 2.46291723665037e-20 NA NA NA hsa-miR-200b-3p PHACTR2 2.11744072703209 1.66710572104191e-43 -1.0916982358773 4.3094820433717e-28 MirTarget -0.253075663375176 1.21293959109688e-33 NA NA NA hsa-miR-200c-3p PHACTR2 2.07038651806183 6.84613386286599e-51 -1.0916982358773 4.3094820433717e-28 MirTarget;miRNATAP -0.249569509159602 6.22668441783385e-27 NA NA NA hsa-miR-21-5p PHACTR2 2.32007501846389 3.08394781855554e-137 -1.0916982358773 4.3094820433717e-28 miRNAWalker2_validate -0.271937515832 4.74116250555523e-18 NA NA NA hsa-miR-429 PHACTR2 2.84108892259147 3.88520896426515e-64 -1.0916982358773 4.3094820433717e-28 MirTarget;PITA;miRNATAP -0.194392373614917 8.89679165098053e-25 NA NA NA hsa-miR-96-5p PHACTR2 3.24596558166606 1.92296159041707e-98 -1.0916982358773 4.3094820433717e-28 mirMAP -0.205400753033821 2.18451391857472e-25 NA NA NA hsa-miR-200b-3p PHACTR3 2.11744072703209 1.66710572104191e-43 -0.558869946890798 0.00128355217613313 MirTarget;TargetScan -0.141052439212467 0.000128160137346357 NA NA NA hsa-miR-200c-3p PHACTR3 2.07038651806183 6.84613386286599e-51 -0.558869946890798 0.00128355217613313 MirTarget;miRNATAP -0.191995024047058 2.01532175699045e-06 NA NA NA hsa-miR-200b-3p PHEX 2.11744072703209 1.66710572104191e-43 0.563027895897396 0.00624446021292856 MirTarget -0.100334825094466 0.0218911356211177 NA NA NA hsa-miR-21-3p PHF2 2.17476065946878 5.15299442583591e-75 -0.292122901286557 3.82912386349539e-07 MirTarget -0.112078687736837 7.71081231811435e-14 NA NA NA hsa-miR-139-5p PHF6 -3.25846663863766 2.62018989415003e-112 0.289673557327313 0.000100808315441901 MirTarget;PITA;miRanda -0.119236577484231 3.17631051343779e-15 NA NA NA hsa-miR-21-5p PHIP 2.32007501846389 3.08394781855554e-137 -0.498419042824399 8.48405672942992e-11 miRNAWalker2_validate -0.226522172032416 7.67246581249718e-22 NA NA NA hsa-miR-139-5p PHKA1 -3.25846663863766 2.62018989415003e-112 0.381013634747799 3.54604148762824e-05 miRanda -0.126866024561873 1.58120240252368e-11 NA NA NA hsa-miR-335-5p PHKG2 -2.61355235628987 2.6462884165886e-51 1.17584598160819 7.15388386958662e-52 mirMAP -0.127636840194731 2.6724863893531e-17 NA NA NA hsa-miR-182-5p PHLDB1 2.36408084103818 2.60011457600281e-72 -1.04573367086873 2.72515970448509e-38 miRNATAP -0.237582717237958 1.25259772757491e-34 NA NA NA hsa-miR-200b-3p PHLDB1 2.11744072703209 1.66710572104191e-43 -1.04573367086873 2.72515970448509e-38 MirTarget;TargetScan -0.234096978292779 6.33415993581434e-43 NA NA NA hsa-miR-200c-3p PHLDB1 2.07038651806183 6.84613386286599e-51 -1.04573367086873 2.72515970448509e-38 MirTarget;miRNATAP -0.320341173447904 4.08141116217833e-70 NA NA NA hsa-miR-429 PHLDB1 2.84108892259147 3.88520896426515e-64 -1.04573367086873 2.72515970448509e-38 MirTarget;PITA;miRanda;miRNATAP -0.213863508049016 4.33014959078877e-45 NA NA NA hsa-miR-96-5p PHLDB1 3.24596558166606 1.92296159041707e-98 -1.04573367086873 2.72515970448509e-38 TargetScan -0.226773039610229 1.17334047789921e-46 NA NA NA hsa-miR-183-5p PHLDB2 2.95681814393872 1.09965777344285e-92 -1.52886087792982 3.79602264606186e-29 MirTarget -0.244126934469769 7.19371233594746e-17 NA NA NA hsa-miR-429 PHLDB2 2.84108892259147 3.88520896426515e-64 -1.52886087792982 3.79602264606186e-29 miRanda -0.323055023652081 1.95003955114776e-36 NA NA NA hsa-miR-429 PHOSPHO1 2.84108892259147 3.88520896426515e-64 -1.0027688238927 1.36100127801636e-09 miRNATAP -0.17480631079315 2.70469192833961e-08 NA NA NA hsa-miR-145-5p PHRF1 -2.62703571936687 7.64402900188551e-88 0.397148160140797 3.15615876944519e-08 MirTarget;miRNATAP -0.160290305058655 1.13216870565306e-22 NA NA NA hsa-miR-139-5p PHTF1 -3.25846663863766 2.62018989415003e-112 0.686539569871927 1.12163554144836e-24 miRanda -0.121351552629626 2.42486452759839e-18 NA NA NA hsa-miR-139-5p PHTF2 -3.25846663863766 2.62018989415003e-112 0.479706580719906 5.71773158345228e-12 miRanda -0.113754244749029 1.55599623417988e-15 NA NA NA hsa-miR-141-3p PHYHIPL 2.99777540204168 1.26370498493024e-78 -2.11508828895346 7.32933510596028e-24 MirTarget;TargetScan;miRNATAP -0.334168282042049 6.0501781021457e-16 NA NA NA hsa-miR-182-5p PHYHIPL 2.36408084103818 2.60011457600281e-72 -2.11508828895346 7.32933510596028e-24 miRNATAP -0.398693967380209 3.71721366446631e-15 NA NA NA hsa-miR-200a-3p PHYHIPL 2.55218480823434 2.96135446816238e-51 -2.11508828895346 7.32933510596028e-24 MirTarget;miRNATAP -0.26342496745624 1.09105832303384e-10 NA NA NA hsa-miR-21-3p PHYHIPL 2.17476065946878 5.15299442583591e-75 -2.11508828895346 7.32933510596028e-24 MirTarget -0.389005067431911 4.61365048167526e-12 NA NA NA hsa-miR-375 PHYHIPL 2.09893673049766 1.68351780396203e-16 -2.11508828895346 7.32933510596028e-24 miRanda -0.173476534584885 8.33024866112958e-10 NA NA NA hsa-miR-96-5p PHYHIPL 3.24596558166606 1.92296159041707e-98 -2.11508828895346 7.32933510596028e-24 TargetScan;miRNATAP -0.395346960625514 2.66328293925472e-21 NA NA NA hsa-miR-21-5p PI15 2.32007501846389 3.08394781855554e-137 -3.08073471667143 1.08580488186246e-23 mirMAP -0.86771201768414 2.26388320401889e-19 NA NA NA hsa-miR-429 PI15 2.84108892259147 3.88520896426515e-64 -3.08073471667143 1.08580488186246e-23 miRanda;miRNATAP -0.220436763774895 0.000225416252569905 NA NA NA hsa-miR-200b-3p PICALM 2.11744072703209 1.66710572104191e-43 -0.627041785265885 1.50198956736942e-24 MirTarget -0.130198912876829 1.42356613610767e-23 NA NA NA hsa-miR-200c-3p PICALM 2.07038651806183 6.84613386286599e-51 -0.627041785265885 1.50198956736942e-24 MirTarget -0.144940267147938 3.74395849781387e-24 NA NA NA hsa-miR-429 PICALM 2.84108892259147 3.88520896426515e-64 -0.627041785265885 1.50198956736942e-24 MirTarget;miRanda;miRNATAP -0.105206336747128 2.15620365209285e-19 NA NA NA hsa-miR-429 PID1 2.84108892259147 3.88520896426515e-64 -2.72417020699254 1.07545341346273e-63 miRNATAP -0.456573950145911 3.03364908797984e-48 NA NA NA hsa-miR-139-5p PIGW -3.25846663863766 2.62018989415003e-112 0.491368618735534 3.34957543940219e-10 miRanda -0.109368615358863 1.01475593311189e-11 NA NA NA hsa-miR-182-5p PIK3AP1 2.36408084103818 2.60011457600281e-72 -0.0218481929973899 0.849092455363106 MirTarget -0.182778303086684 1.34564536779175e-11 NA NA NA hsa-miR-21-5p PIK3C2A 2.32007501846389 3.08394781855554e-137 -0.641163417209961 3.74744793483141e-13 miRNAWalker2_validate -0.270607830740225 2.15289219729295e-23 NA NA NA hsa-miR-429 PIK3C2G 2.84108892259147 3.88520896426515e-64 -3.86485508746028 4.79617517182444e-31 miRanda;miRNATAP -0.351797636553294 6.99931313128122e-08 NA NA NA hsa-miR-200b-3p PIK3CA 2.11744072703209 1.66710572104191e-43 -0.881957552231161 1.15529457057533e-22 TargetScan -0.164394431071602 1.25931440199374e-17 NA NA NA hsa-miR-96-5p PIK3CA 3.24596558166606 1.92296159041707e-98 -0.881957552231161 1.15529457057533e-22 TargetScan -0.158039482109614 1.06514304964241e-18 NA NA NA hsa-miR-429 PIK3IP1 2.84108892259147 3.88520896426515e-64 -0.814447667311242 5.38721712007383e-22 miRNATAP -0.158886813218329 2.72234798973014e-23 NA NA NA hsa-miR-182-5p PIK3R1 2.36408084103818 2.60011457600281e-72 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.209986504782115 4.31661758321545e-12 NA NA NA hsa-miR-200b-3p PIK3R1 2.11744072703209 1.66710572104191e-43 -1.70627489565512 1.28475917565256e-44 mirMAP -0.193888157381114 6.36921236487692e-13 NA NA NA hsa-miR-200c-3p PIK3R1 2.07038651806183 6.84613386286599e-51 -1.70627489565512 1.28475917565256e-44 mirMAP -0.257145031020416 2.3912254219973e-18 NA NA NA hsa-miR-21-5p PIK3R1 2.32007501846389 3.08394781855554e-137 -1.70627489565512 1.28475917565256e-44 miRNAWalker2_validate;MirTarget;miRNATAP -0.442813578327247 2.68375696066295e-30 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-429 PIK3R1 2.84108892259147 3.88520896426515e-64 -1.70627489565512 1.28475917565256e-44 mirMAP;miRNATAP -0.22503499935046 3.34180951947627e-21 NA NA NA hsa-miR-96-5p PIK3R1 3.24596558166606 1.92296159041707e-98 -1.70627489565512 1.28475917565256e-44 TargetScan;miRNATAP -0.245653154038236 3.77424010710224e-23 NA NA NA hsa-miR-182-5p PIK3R5 2.36408084103818 2.60011457600281e-72 0.311128035887536 0.0038375952038782 MirTarget -0.108305079676846 2.32094065834864e-05 NA NA NA hsa-miR-141-3p PIKFYVE 2.99777540204168 1.26370498493024e-78 -0.856697691591447 3.59347529295631e-24 MirTarget -0.136376911845397 2.08057028047207e-16 NA NA NA hsa-miR-200a-3p PIKFYVE 2.55218480823434 2.96135446816238e-51 -0.856697691591447 3.59347529295631e-24 MirTarget -0.121096803902981 1.26460022019514e-13 NA NA NA hsa-miR-200b-3p PIKFYVE 2.11744072703209 1.66710572104191e-43 -0.856697691591447 3.59347529295631e-24 MirTarget;TargetScan -0.132349216178503 3.41125325851376e-13 NA NA NA hsa-miR-200c-3p PIKFYVE 2.07038651806183 6.84613386286599e-51 -0.856697691591447 3.59347529295631e-24 MirTarget;miRNATAP -0.142430317245247 1.10361204942165e-12 NA NA NA hsa-miR-21-5p PIKFYVE 2.32007501846389 3.08394781855554e-137 -0.856697691591447 3.59347529295631e-24 MirTarget -0.300600782379684 1.16284328419149e-30 NA NA NA hsa-miR-429 PIKFYVE 2.84108892259147 3.88520896426515e-64 -0.856697691591447 3.59347529295631e-24 MirTarget;miRanda;miRNATAP -0.135684455296869 4.55406065029762e-17 NA NA NA hsa-miR-183-5p PIM1 2.95681814393872 1.09965777344285e-92 -0.543245722142204 4.23045104516197e-06 miRNATAP -0.184619636188661 7.11720554709785e-14 NA NA NA hsa-miR-429 PIM1 2.84108892259147 3.88520896426515e-64 -0.543245722142204 4.23045104516197e-06 miRNATAP -0.103768468392563 3.58813451862755e-06 NA NA NA hsa-miR-139-5p PIN4 -3.25846663863766 2.62018989415003e-112 0.492480456895908 2.24610779747676e-12 miRanda -0.108410310479927 5.36180989859624e-14 NA NA NA hsa-miR-183-5p PITPNM2 2.95681814393872 1.09965777344285e-92 -0.711603200759714 6.63855978163518e-11 mirMAP -0.143824276739795 4.14031027558217e-10 NA NA NA hsa-miR-141-3p PITX2 2.99777540204168 1.26370498493024e-78 -0.446534217465074 0.0204393455572554 TargetScan;miRNATAP -0.223717264715575 1.74572061948343e-09 NA NA NA hsa-miR-200a-3p PITX2 2.55218480823434 2.96135446816238e-51 -0.446534217465074 0.0204393455572554 miRNATAP -0.2225102743152 1.03072167409031e-09 NA NA NA hsa-miR-21-5p PJA2 2.32007501846389 3.08394781855554e-137 -0.861595497733361 1.07188296663498e-25 MirTarget -0.328671664212152 6.68261606142016e-39 NA NA NA hsa-miR-429 PJA2 2.84108892259147 3.88520896426515e-64 -0.861595497733361 1.07188296663498e-25 miRanda;miRNATAP -0.147213281368292 5.94357063962706e-21 NA NA NA hsa-miR-429 PKD1L1 2.84108892259147 3.88520896426515e-64 -1.13731177018652 2.11216301823645e-15 miRanda -0.197349609415527 4.59358834011767e-13 NA NA NA hsa-miR-183-5p PKD2 2.95681814393872 1.09965777344285e-92 -1.64090715886338 1.07849232924274e-56 MirTarget;miRNATAP -0.327505100732289 3.97030360073012e-50 NA NA NA hsa-miR-21-5p PKD2 2.32007501846389 3.08394781855554e-137 -1.64090715886338 1.07849232924274e-56 miRNAWalker2_validate -0.32797302079002 2.50351907689772e-22 NA NA NA hsa-miR-429 PKD2 2.84108892259147 3.88520896426515e-64 -1.64090715886338 1.07849232924274e-56 miRanda;miRNATAP -0.281244375782366 2.26306362817557e-45 NA NA NA hsa-miR-429 PKHD1 2.84108892259147 3.88520896426515e-64 -1.11442196624809 9.50524159652961e-06 miRanda -0.113501268874065 0.0179248756583955 NA NA NA hsa-miR-429 PKHD1L1 2.84108892259147 3.88520896426515e-64 -4.42984186852189 2.04446231933931e-67 miRanda -0.481443076739381 8.5268841864066e-21 NA NA NA hsa-miR-200a-3p PKIA 2.55218480823434 2.96135446816238e-51 -1.53571066596047 4.62934386564947e-14 mirMAP -0.361517924934796 6.63134739334438e-21 NA NA NA hsa-miR-200b-3p PKIA 2.11744072703209 1.66710572104191e-43 -1.53571066596047 4.62934386564947e-14 MirTarget;TargetScan -0.35239894901475 3.09338480263276e-16 NA NA NA hsa-miR-200c-3p PKIA 2.07038651806183 6.84613386286599e-51 -1.53571066596047 4.62934386564947e-14 MirTarget;miRNATAP -0.36206104356032 2.66841796132117e-14 NA NA NA hsa-miR-429 PKIA 2.84108892259147 3.88520896426515e-64 -1.53571066596047 4.62934386564947e-14 MirTarget;PITA;miRanda;miRNATAP -0.305242173777674 2.47111464310013e-15 NA NA NA hsa-miR-183-5p PKNOX2 2.95681814393872 1.09965777344285e-92 -2.4009145580402 1.00472039051525e-29 miRNATAP -0.475309307545682 4.09531175198925e-26 NA NA NA hsa-miR-429 PKP1 2.84108892259147 3.88520896426515e-64 -2.70332431186329 9.09197282880777e-18 miRanda;miRNATAP -0.221544542755124 0.000269643472623809 NA NA NA hsa-miR-335-5p PLA2G10 -2.61355235628987 2.6462884165886e-51 2.58043646182214 4.92737062096255e-20 miRNAWalker2_validate -0.240771211021386 6.4577488535009e-06 NA NA NA hsa-miR-10b-5p PLA2G15 -2.10996264627796 7.36811595736367e-72 0.406293251615607 1.581210297859e-09 MirTarget -0.103312530635972 8.61096905567356e-09 NA NA NA hsa-miR-429 PLA2G5 2.84108892259147 3.88520896426515e-64 -1.74013770344495 1.68659762319176e-24 miRanda -0.333900447814793 4.56777352167666e-25 NA NA NA hsa-miR-141-3p PLA2R1 2.99777540204168 1.26370498493024e-78 -1.74661378073068 1.09491748872223e-46 mirMAP -0.290912341077658 1.49547340397695e-33 NA NA NA hsa-miR-141-3p PLAG1 2.99777540204168 1.26370498493024e-78 -1.22970054692881 5.65960696224232e-15 TargetScan;miRNATAP -0.195363034371323 2.35535488719952e-10 NA NA NA hsa-miR-141-5p PLAG1 2.38411349683216 4.56310582620282e-58 -1.22970054692881 5.65960696224232e-15 MirTarget -0.160741630169463 2.68642477328514e-06 NA NA NA hsa-miR-182-5p PLAG1 2.36408084103818 2.60011457600281e-72 -1.22970054692881 5.65960696224232e-15 mirMAP -0.314665785901232 4.46874022889278e-17 NA NA NA hsa-miR-183-5p PLAG1 2.95681814393872 1.09965777344285e-92 -1.22970054692881 5.65960696224232e-15 miRNATAP -0.238560182873114 8.06157574583377e-13 NA NA NA hsa-miR-200a-3p PLAG1 2.55218480823434 2.96135446816238e-51 -1.22970054692881 5.65960696224232e-15 miRNATAP -0.182152441306119 1.80422008866561e-09 NA NA NA hsa-miR-21-5p PLAG1 2.32007501846389 3.08394781855554e-137 -1.22970054692881 5.65960696224232e-15 MirTarget;miRNATAP -0.297005735699583 1.97188045183731e-09 NA NA NA hsa-miR-375 PLAG1 2.09893673049766 1.68351780396203e-16 -1.22970054692881 5.65960696224232e-15 miRNAWalker2_validate;miRTarBase;mirMAP -0.159268648639397 1.93878849620109e-14 NA NA NA hsa-miR-429 PLAG1 2.84108892259147 3.88520896426515e-64 -1.22970054692881 5.65960696224232e-15 miRanda;miRNATAP -0.172808287644824 9.48510486452813e-09 NA NA NA hsa-miR-96-5p PLAGL1 3.24596558166606 1.92296159041707e-98 -2.12889134481713 4.05998658470338e-50 TargetScan -0.419579232588954 1.23934073700194e-49 NA NA NA hsa-miR-21-5p PLAT 2.32007501846389 3.08394781855554e-137 -0.702112551655769 9.14307616771267e-05 miRNAWalker2_validate;miRTarBase -0.15220333311024 0.00672105587093083 19308091 We also demonstrated that both deltaEF1 and TPA induced miR-21 expression breast cancer hsa-miR-139-5p PLAUR -3.25846663863766 2.62018989415003e-112 1.72201143929991 8.4340887072744e-43 miRanda -0.35194053096789 4.85749810589543e-42 NA NA NA hsa-miR-429 PLB1 2.84108892259147 3.88520896426515e-64 -0.85804288786934 9.82047471059358e-11 miRNATAP -0.129624717250396 2.89665560766075e-07 NA NA NA hsa-miR-106b-5p PLCB1 1.22477789913175 2.31787213143326e-32 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.353580999854292 7.45108046911457e-10 NA NA NA hsa-miR-107 PLCB1 0.678998026350662 2.56224148930538e-16 -1.66992751550185 3.40855270132597e-21 PITA;miRanda;miRNATAP -0.43540927048432 3.17440164078589e-09 NA NA NA hsa-miR-130b-3p PLCB1 1.38122163823846 1.00932179737836e-26 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.196209100856761 2.76427536384308e-05 NA NA NA hsa-miR-16-2-3p PLCB1 0.286355254959005 0.0256946046884474 -1.66992751550185 3.40855270132597e-21 mirMAP -0.181891575863844 0.000186734623561594 NA NA NA hsa-miR-17-5p PLCB1 0.599531757298529 1.07318660415906e-05 -1.66992751550185 3.40855270132597e-21 TargetScan;miRNATAP -0.14694574384319 0.00121463038460002 NA NA NA hsa-miR-19a-3p PLCB1 0.817507952171848 3.76285090469625e-08 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.133824099939887 0.00125180775640206 NA NA NA hsa-miR-20a-5p PLCB1 0.44979911120222 0.000602386964327228 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.199775783667376 2.30541192654188e-05 NA NA NA hsa-miR-301a-3p PLCB1 1.32170168375632 2.12280368957514e-15 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.142645627899033 0.000107371010712177 NA NA NA hsa-miR-320b PLCB1 0.412787504747938 0.00113457276903985 -1.66992751550185 3.40855270132597e-21 miRanda -0.120787772689584 0.0141916864456668 NA NA NA hsa-miR-340-5p PLCB1 1.0857159627596 4.94471062546756e-24 -1.66992751550185 3.40855270132597e-21 mirMAP -0.145430096241242 0.00999016493511445 NA NA NA hsa-miR-34a-5p PLCB1 0.129201805242403 0.133261654068224 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.159895868887965 0.0280175727961689 NA NA NA hsa-miR-429 PLCB1 2.84108892259147 3.88520896426515e-64 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.224224441826941 4.11678198698433e-11 NA NA NA hsa-miR-454-3p PLCB1 1.28177672191095 6.84024979484587e-21 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.199095150598467 7.7170942260896e-06 NA NA NA hsa-miR-590-3p PLCB1 1.27438512890514 1.03164723481469e-23 -1.66992751550185 3.40855270132597e-21 PITA;miRanda;mirMAP -0.163197561436935 0.00104240143511447 NA NA NA hsa-miR-93-5p PLCB1 1.01788600209314 1.24312921618126e-21 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.375873317446529 2.70002798262841e-11 NA NA NA hsa-let-7b-5p PLCB3 -0.54215483448257 7.21347617597858e-08 0.765853609646934 4.18411290839255e-25 miRNAWalker2_validate -0.16887583502616 4.06103235376535e-11 NA NA NA hsa-miR-125a-5p PLCB3 -0.635694700253268 3.6703235721638e-11 0.765853609646934 4.18411290839255e-25 miRanda -0.184282319096659 4.86720731110882e-12 NA NA NA hsa-let-7a-3p PLCB4 0.466622567891891 3.70886257943079e-07 -0.971426359987884 2.28823451814059e-07 mirMAP;miRNATAP -0.19467309283188 0.00578258252733417 NA NA NA hsa-let-7a-5p PLCB4 -0.210286642041636 0.0072546234707717 -0.971426359987884 2.28823451814059e-07 miRNATAP -0.164772567366254 0.048408998790875 NA NA NA hsa-let-7e-5p PLCB4 0.261471269338985 0.00191077095550257 -0.971426359987884 2.28823451814059e-07 miRNATAP -0.194802452833621 0.0118202484022476 NA NA NA hsa-miR-141-3p PLCB4 2.99777540204168 1.26370498493024e-78 -0.971426359987884 2.28823451814059e-07 TargetScan -0.129122335963341 0.000435434137519319 NA NA NA hsa-miR-361-5p PLCB4 -0.0996867547900457 0.095428250126326 -0.971426359987884 2.28823451814059e-07 miRanda -0.243037400239062 0.0276985603373769 NA NA NA hsa-miR-429 PLCB4 2.84108892259147 3.88520896426515e-64 -0.971426359987884 2.28823451814059e-07 miRanda -0.132358033926964 0.00021397529104974 NA NA NA hsa-miR-96-5p PLCB4 3.24596558166606 1.92296159041707e-98 -0.971426359987884 2.28823451814059e-07 TargetScan;miRNATAP -0.157435127267557 2.40435360053082e-05 NA NA NA hsa-miR-96-5p PLCE1 3.24596558166606 1.92296159041707e-98 -1.32404162040811 1.41903528474939e-14 TargetScan -0.248175684735906 3.58441889575789e-13 NA NA NA hsa-miR-375 PLCH1 2.09893673049766 1.68351780396203e-16 -0.404982696404933 0.181998504172079 miRanda -0.24246295657848 9.86687480085553e-10 NA NA NA hsa-miR-486-5p PLCH1 -3.87258704301474 1.22658629378451e-80 -0.404982696404933 0.181998504172079 miRanda -0.130003379440728 0.0047986100224284 NA NA NA hsa-miR-183-5p PLCH2 2.95681814393872 1.09965777344285e-92 -1.1541408820057 4.38010587989886e-08 mirMAP -0.204029495887316 4.81034538691069e-06 NA NA NA hsa-miR-141-3p PLCL1 2.99777540204168 1.26370498493024e-78 -0.861592973460026 2.13570934923443e-07 MirTarget;TargetScan -0.220218414690715 7.35851061939504e-12 NA NA NA hsa-miR-200a-3p PLCL1 2.55218480823434 2.96135446816238e-51 -0.861592973460026 2.13570934923443e-07 MirTarget -0.179921519453597 1.34473772332191e-08 NA NA NA hsa-miR-200b-3p PLCL1 2.11744072703209 1.66710572104191e-43 -0.861592973460026 2.13570934923443e-07 MirTarget;TargetScan -0.186560505331726 1.23050603915014e-07 NA NA NA hsa-miR-200c-3p PLCL1 2.07038651806183 6.84613386286599e-51 -0.861592973460026 2.13570934923443e-07 MirTarget -0.277039669837228 6.37214256514421e-13 NA NA NA hsa-miR-429 PLCL1 2.84108892259147 3.88520896426515e-64 -0.861592973460026 2.13570934923443e-07 MirTarget;PITA;miRanda;miRNATAP -0.183668863448299 5.1709413047575e-09 NA NA NA hsa-miR-429 PLCL2 2.84108892259147 3.88520896426515e-64 -1.30045666681829 6.0626151916402e-29 miRanda;miRNATAP -0.282991085739733 1.68851866046948e-38 NA NA NA hsa-miR-141-3p PLCXD3 2.99777540204168 1.26370498493024e-78 -3.5618826851907 6.32920306664313e-37 TargetScan;miRNATAP -0.819970693742895 4.97187894848886e-53 NA NA NA hsa-miR-183-5p PLCXD3 2.95681814393872 1.09965777344285e-92 -3.5618826851907 6.32920306664313e-37 miRNATAP -0.700091965372875 7.77138523188663e-32 NA NA NA hsa-miR-200a-3p PLCXD3 2.55218480823434 2.96135446816238e-51 -3.5618826851907 6.32920306664313e-37 miRNATAP -0.609698480165206 1.97732293811626e-29 NA NA NA hsa-miR-200a-5p PLCXD3 2.58844508672328 1.79650654234569e-56 -3.5618826851907 6.32920306664313e-37 mirMAP -0.587564573675355 4.93291313691244e-26 NA NA NA hsa-miR-200b-3p PLCXD3 2.11744072703209 1.66710572104191e-43 -3.5618826851907 6.32920306664313e-37 TargetScan -0.611157162653787 6.94552205471737e-24 NA NA NA hsa-miR-21-3p PLCXD3 2.17476065946878 5.15299442583591e-75 -3.5618826851907 6.32920306664313e-37 mirMAP -0.909070847107719 1.71070948465315e-34 NA NA NA hsa-miR-429 PLCXD3 2.84108892259147 3.88520896426515e-64 -3.5618826851907 6.32920306664313e-37 PITA;miRanda;miRNATAP -0.626880281622804 1.36632163129852e-31 NA NA NA hsa-miR-182-5p PLD1 2.36408084103818 2.60011457600281e-72 -1.5146574391925 4.86890569784769e-35 MirTarget;miRNATAP -0.397084089244162 8.74101988435737e-43 NA NA NA hsa-miR-183-5p PLD1 2.95681814393872 1.09965777344285e-92 -1.5146574391925 4.86890569784769e-35 mirMAP -0.310405033593345 5.47774252509361e-33 NA NA NA hsa-miR-21-5p PLD1 2.32007501846389 3.08394781855554e-137 -1.5146574391925 4.86890569784769e-35 miRNAWalker2_validate -0.281512820182814 9.16457525889775e-13 NA NA NA hsa-miR-96-5p PLD1 3.24596558166606 1.92296159041707e-98 -1.5146574391925 4.86890569784769e-35 miRNATAP -0.328385773592716 1.75638569124427e-42 NA NA NA hsa-miR-335-5p PLD4 -2.61355235628987 2.6462884165886e-51 0.789595694749843 0.000100059118346391 miRNAWalker2_validate -0.107935623130426 0.00434212438749646 NA NA NA hsa-miR-375 PLD5 2.09893673049766 1.68351780396203e-16 -3.60457806400539 7.30122052927803e-48 miRanda -0.187809454046636 5.33370273502768e-08 NA NA NA hsa-miR-141-3p PLEK 2.99777540204168 1.26370498493024e-78 0.170820097329674 0.196220259814462 MirTarget;TargetScan -0.100345357365683 8.98816706507767e-05 NA NA NA hsa-miR-21-5p PLEKHA1 2.32007501846389 3.08394781855554e-137 -0.256048068362449 0.00011802569949323 miRNAWalker2_validate;MirTarget;miRNATAP -0.107933087486065 1.70573247872038e-07 NA NA NA hsa-miR-378a-5p PLEKHG3 -2.43173551693523 1.44932837789175e-68 0.186460167381627 0.0152232630190883 mirMAP -0.123980885643003 5.01456356448469e-13 NA NA NA hsa-miR-335-5p PLEKHG4B -2.61355235628987 2.6462884165886e-51 0.300624112948364 0.214246951183672 mirMAP -0.139268202786781 0.00194028898309324 NA NA NA hsa-miR-182-5p PLEKHH2 2.36408084103818 2.60011457600281e-72 -2.39608536576746 1.14497948259556e-46 MirTarget -0.431662864466751 5.62569667794416e-26 NA NA NA hsa-miR-429 PLEKHH2 2.84108892259147 3.88520896426515e-64 -2.39608536576746 1.14497948259556e-46 miRanda -0.364427987775922 2.46769832673927e-29 NA NA NA hsa-miR-182-5p PLEKHM1 2.36408084103818 2.60011457600281e-72 -0.574588899361219 3.37380734115881e-24 miRNATAP -0.115650166634382 1.78237939999176e-17 NA NA NA hsa-miR-183-5p PLEKHM1 2.95681814393872 1.09965777344285e-92 -0.574588899361219 3.37380734115881e-24 miRNAWalker2_validate -0.138043310402247 1.30117184869226e-31 NA NA NA hsa-miR-96-5p PLEKHM1 3.24596558166606 1.92296159041707e-98 -0.574588899361219 3.37380734115881e-24 TargetScan;miRNATAP -0.116996791177673 9.99423398045656e-26 NA NA NA hsa-miR-183-5p PLEKHM3 2.95681814393872 1.09965777344285e-92 -1.84131497880035 1.34528076669196e-67 MirTarget -0.294359617270532 1.12099964298184e-36 NA NA NA hsa-miR-200b-3p PLEKHM3 2.11744072703209 1.66710572104191e-43 -1.84131497880035 1.34528076669196e-67 MirTarget;TargetScan -0.241333647212449 3.86287713007947e-24 NA NA NA hsa-miR-200c-3p PLEKHM3 2.07038651806183 6.84613386286599e-51 -1.84131497880035 1.34528076669196e-67 MirTarget -0.287353017866813 2.59577926133476e-28 NA NA NA hsa-miR-429 PLEKHM3 2.84108892259147 3.88520896426515e-64 -1.84131497880035 1.34528076669196e-67 MirTarget;miRanda;miRNATAP -0.247407146905979 6.63327060386922e-32 NA NA NA hsa-miR-429 PLEKHO2 2.84108892259147 3.88520896426515e-64 -0.34222749966927 1.12075981868708e-05 miRNATAP -0.128479814316411 8.21755125799348e-19 NA NA NA hsa-miR-21-3p PLGLB2 2.17476065946878 5.15299442583591e-75 -0.172139684066127 0.0666632661294132 MirTarget -0.104660110148945 2.12621951832842e-05 NA NA NA hsa-miR-486-5p PLK1 -3.87258704301474 1.22658629378451e-80 3.61536656799676 6.1989940433249e-93 miRanda -0.334945892330245 1.38948539792593e-30 NA NA NA hsa-miR-335-5p PLOD1 -2.61355235628987 2.6462884165886e-51 0.521002840675697 3.31989407116238e-09 MirTarget -0.125991145228986 9.01329780519339e-15 NA NA NA hsa-miR-182-5p PLOD2 2.36408084103818 2.60011457600281e-72 -0.195188455576747 0.156394291495433 miRNATAP -0.262093222925603 4.37016004664184e-16 NA NA NA hsa-miR-183-5p PLOD2 2.95681814393872 1.09965777344285e-92 -0.195188455576747 0.156394291495433 miRNAWalker2_validate -0.118606450069159 4.14678296067971e-05 NA NA NA hsa-miR-429 PLOD2 2.84108892259147 3.88520896426515e-64 -0.195188455576747 0.156394291495433 miRanda -0.108354265284 3.08396822995437e-05 NA NA NA hsa-miR-96-5p PLOD2 3.24596558166606 1.92296159041707e-98 -0.195188455576747 0.156394291495433 MirTarget;TargetScan;miRNATAP -0.15706241240377 6.06497617923989e-09 NA NA NA hsa-miR-200b-3p PLS3 2.11744072703209 1.66710572104191e-43 -1.1188566933368 4.91386750614017e-22 TargetScan -0.281881276242237 4.81447933812582e-31 NA NA NA hsa-miR-429 PLS3 2.84108892259147 3.88520896426515e-64 -1.1188566933368 4.91386750614017e-22 PITA;miRanda;miRNATAP -0.22273345764431 2.95206933158149e-24 NA NA NA hsa-miR-141-3p PLXDC1 2.99777540204168 1.26370498493024e-78 -0.181187214482674 0.0645908903217389 TargetScan -0.158737173761504 2.02327874595318e-17 NA NA NA hsa-miR-429 PLXDC1 2.84108892259147 3.88520896426515e-64 -0.181187214482674 0.0645908903217389 miRNATAP -0.148159580369711 4.66066461960985e-16 NA NA NA hsa-miR-96-5p PLXDC1 3.24596558166606 1.92296159041707e-98 -0.181187214482674 0.0645908903217389 mirMAP -0.115048786127425 2.12920688416847e-09 NA NA NA hsa-miR-96-5p PLXDC2 3.24596558166606 1.92296159041707e-98 -0.294117954809918 0.00859136297363429 TargetScan -0.144968998604473 3.69097229505685e-11 NA NA NA hsa-miR-200b-3p PLXNA2 2.11744072703209 1.66710572104191e-43 -0.293557303793948 0.00573633661157915 TargetScan -0.127054491842765 1.40894493883852e-08 NA NA NA hsa-miR-429 PLXNA2 2.84108892259147 3.88520896426515e-64 -0.293557303793948 0.00573633661157915 miRanda;miRNATAP -0.101684003607352 3.89259238837486e-07 NA NA NA hsa-miR-335-5p PLXNA3 -2.61355235628987 2.6462884165886e-51 1.0687945782394 4.41036471956354e-38 miRNAWalker2_validate -0.107864081236009 1.32879771714855e-11 NA NA NA hsa-miR-141-3p PLXNA4 2.99777540204168 1.26370498493024e-78 -3.24060572750455 3.5769955557962e-61 TargetScan;miRNATAP -0.638005395400365 8.80013447469558e-63 NA NA NA hsa-miR-182-5p PLXNA4 2.36408084103818 2.60011457600281e-72 -3.24060572750455 3.5769955557962e-61 mirMAP -0.540641205134481 2.08169535661097e-28 NA NA NA hsa-miR-183-5p PLXNA4 2.95681814393872 1.09965777344285e-92 -3.24060572750455 3.5769955557962e-61 miRNATAP -0.550855474819579 4.59210386794617e-38 NA NA NA hsa-miR-200a-3p PLXNA4 2.55218480823434 2.96135446816238e-51 -3.24060572750455 3.5769955557962e-61 mirMAP;miRNATAP -0.520118939371117 1.17337551468408e-41 NA NA NA hsa-miR-200b-3p PLXNA4 2.11744072703209 1.66710572104191e-43 -3.24060572750455 3.5769955557962e-61 TargetScan -0.560429430413497 6.14792482365742e-39 NA NA NA hsa-miR-200c-3p PLXNA4 2.07038651806183 6.84613386286599e-51 -3.24060572750455 3.5769955557962e-61 miRNATAP -0.695362378238331 1.50531990318095e-50 NA NA NA hsa-miR-375 PLXNA4 2.09893673049766 1.68351780396203e-16 -3.24060572750455 3.5769955557962e-61 miRNATAP -0.222067359845538 7.10685536887717e-16 NA NA NA hsa-miR-429 PLXNA4 2.84108892259147 3.88520896426515e-64 -3.24060572750455 3.5769955557962e-61 PITA;miRNATAP -0.528496951044311 9.48277734128391e-44 NA NA NA hsa-miR-96-5p PLXNA4 3.24596558166606 1.92296159041707e-98 -3.24060572750455 3.5769955557962e-61 mirMAP -0.54664187400587 6.73745216118883e-43 NA NA NA hsa-miR-141-3p PLXNC1 2.99777540204168 1.26370498493024e-78 -0.138164570454698 0.490888361136795 TargetScan;miRNATAP -0.197318592223399 3.55833404294406e-07 NA NA NA hsa-miR-200a-3p PLXNC1 2.55218480823434 2.96135446816238e-51 -0.138164570454698 0.490888361136795 miRNATAP -0.192251312941787 4.29328184204721e-07 NA NA NA hsa-miR-200b-3p PLXNC1 2.11744072703209 1.66710572104191e-43 -0.138164570454698 0.490888361136795 TargetScan -0.195053227062515 4.1104191023972e-06 NA NA NA hsa-miR-200c-3p PLXNC1 2.07038651806183 6.84613386286599e-51 -0.138164570454698 0.490888361136795 miRNATAP -0.195025765062541 2.87438108523045e-05 NA NA NA hsa-miR-429 PLXNC1 2.84108892259147 3.88520896426515e-64 -0.138164570454698 0.490888361136795 miRNATAP -0.191559938029635 3.93420701602295e-07 NA NA NA hsa-miR-141-5p PM20D2 2.38411349683216 4.56310582620282e-58 -1.70732328537926 4.48130308012845e-22 MirTarget -0.173807427987975 7.64882298909811e-06 NA NA NA hsa-miR-21-5p PM20D2 2.32007501846389 3.08394781855554e-137 -1.70732328537926 4.48130308012845e-22 miRNAWalker2_validate;MirTarget -0.490778104606543 8.24217953453834e-19 NA NA NA hsa-miR-429 PM20D2 2.84108892259147 3.88520896426515e-64 -1.70732328537926 4.48130308012845e-22 miRanda -0.122068137791366 0.000376978708062393 NA NA NA hsa-miR-429 PMP22 2.84108892259147 3.88520896426515e-64 -0.846523884939232 4.48556003485439e-15 PITA;miRanda;miRNATAP -0.172480701659585 2.89926476849474e-17 NA NA NA hsa-miR-141-3p PNMA3 2.99777540204168 1.26370498493024e-78 -0.863176542925314 0.000585799145434105 MirTarget -0.136698359647499 0.00522332015187694 NA NA NA hsa-miR-200a-3p PNMA3 2.55218480823434 2.96135446816238e-51 -0.863176542925314 0.000585799145434105 MirTarget -0.122129919598298 0.0110110742443319 NA NA NA hsa-miR-429 PNMAL2 2.84108892259147 3.88520896426515e-64 -1.54727620888284 1.18559481591047e-30 miRNATAP -0.220261127935234 2.08175584079819e-17 NA NA NA hsa-miR-183-5p PNOC 2.95681814393872 1.09965777344285e-92 0.615064667045642 0.00814372837302924 miRNATAP -0.11744604026165 0.0167282649698503 NA NA NA hsa-miR-139-3p PNPLA3 -3.44089023199323 1.67292890850702e-91 0.184847828217612 0.482215149417405 MirTarget -0.133235206990631 0.00497440327011164 NA NA NA hsa-miR-429 PNRC1 2.84108892259147 3.88520896426515e-64 -0.913015711429988 5.18092054507961e-33 miRNATAP -0.10760366584166 4.07611863667695e-13 NA NA NA hsa-miR-335-5p PODXL2 -2.61355235628987 2.6462884165886e-51 1.57646700540282 1.00649516701174e-25 miRNAWalker2_validate -0.164432859304096 8.98877957990923e-09 NA NA NA hsa-miR-99a-5p POGK -2.25079447371102 1.14086813185885e-54 0.801674980396631 1.88660264507077e-33 miRNAWalker2_validate -0.11455366568651 3.39003033081951e-14 NA NA NA hsa-miR-335-5p POLD4 -2.61355235628987 2.6462884165886e-51 0.968886612090659 1.61325793986646e-22 miRNAWalker2_validate -0.10397915417024 3.19999688959037e-08 NA NA NA hsa-miR-200c-3p POLK 2.07038651806183 6.84613386286599e-51 -0.643740598724049 1.80887720530213e-15 MirTarget -0.119652805346443 3.12161470814839e-10 NA NA NA hsa-miR-429 POLK 2.84108892259147 3.88520896426515e-64 -0.643740598724049 1.80887720530213e-15 MirTarget;miRanda;miRNATAP -0.114229477964474 1.07149962274093e-13 NA NA NA hsa-miR-10b-5p POLR1A -2.10996264627796 7.36811595736367e-72 0.2827350354402 8.46056429737681e-05 mirMAP -0.131295513481307 4.63268370375343e-12 NA NA NA hsa-miR-486-5p POLR2H -3.87258704301474 1.22658629378451e-80 1.09255511136751 2.87703156131426e-48 miRanda -0.110770856021471 5.5034066708876e-21 NA NA NA hsa-miR-21-5p POLR3B 2.32007501846389 3.08394781855554e-137 -0.0953096934587196 0.107534244743376 miRNAWalker2_validate -0.117968642623395 9.63198896722134e-11 NA NA NA hsa-miR-182-5p POLR3G 2.36408084103818 2.60011457600281e-72 -0.359844273153965 0.00131601601065885 miRNATAP -0.163837041245065 6.31117525360826e-10 NA NA NA hsa-miR-139-5p POP1 -3.25846663863766 2.62018989415003e-112 0.855038045324445 9.35333783443316e-20 miRanda -0.211798566938136 1.86478334722855e-28 NA NA NA hsa-miR-139-5p POSTN -3.25846663863766 2.62018989415003e-112 1.95056974229455 5.25551662563458e-27 miRanda -0.292091721092793 1.49042827053157e-14 NA NA NA hsa-miR-210-3p POU2AF1 2.38367203491819 3.73261999106754e-22 -0.421206885365678 0.105939521959813 MirTarget -0.165854082952751 2.33166169175905e-06 NA NA NA hsa-miR-182-5p POU2F2 2.36408084103818 2.60011457600281e-72 0.150059201849073 0.217506360049201 miRNATAP -0.135465774891959 2.66745562183594e-06 NA NA NA hsa-miR-335-5p POU2F3 -2.61355235628987 2.6462884165886e-51 0.534392207064869 0.000298375113300244 miRNAWalker2_validate -0.102491529941969 0.000191804723848231 NA NA NA hsa-miR-200b-3p POU6F1 2.11744072703209 1.66710572104191e-43 -1.22160046868415 5.22496483078127e-46 TargetScan -0.160259866602277 2.30858415043228e-17 NA NA NA hsa-miR-429 POU6F1 2.84108892259147 3.88520896426515e-64 -1.22160046868415 5.22496483078127e-46 miRanda -0.17391038002039 2.19031536476861e-25 NA NA NA hsa-miR-141-3p PPARA 2.99777540204168 1.26370498493024e-78 -1.66915873925688 2.97363179285551e-46 miRNAWalker2_validate;miRTarBase -0.247904615736715 2.4815889948105e-26 NA NA NA hsa-miR-200b-3p PPARA 2.11744072703209 1.66710572104191e-43 -1.66915873925688 2.97363179285551e-46 MirTarget -0.259376542668734 3.26243338968945e-24 NA NA NA hsa-miR-200c-3p PPARA 2.07038651806183 6.84613386286599e-51 -1.66915873925688 2.97363179285551e-46 MirTarget -0.290578862789838 3.98530929459165e-25 NA NA NA hsa-miR-21-3p PPARA 2.17476065946878 5.15299442583591e-75 -1.66915873925688 2.97363179285551e-46 mirMAP -0.281340929917267 1.28683125562825e-18 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-21-5p PPARA 2.32007501846389 3.08394781855554e-137 -1.66915873925688 2.97363179285551e-46 miRNAWalker2_validate;miRTarBase;miRNATAP -0.499807555240057 2.55196074428291e-42 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-429 PPARA 2.84108892259147 3.88520896426515e-64 -1.66915873925688 2.97363179285551e-46 MirTarget;miRanda -0.235218089569983 5.74050725062958e-25 NA NA NA hsa-miR-29c-3p PPARD -0.0652732378039769 0.563774115756922 0.268174641566159 4.02572245071487e-05 miRNATAP -0.128141556480419 7.98900291845159e-11 NA NA NA hsa-miR-497-5p PPARD -1.4667331575679 5.49909921822638e-36 0.268174641566159 4.02572245071487e-05 mirMAP -0.108496813581842 2.57101128829637e-09 NA NA NA hsa-miR-429 PPARG 2.84108892259147 3.88520896426515e-64 -3.26817991841726 8.75586156961703e-92 miRNATAP -0.505174513402101 1.79581843862481e-56 NA NA NA hsa-miR-200a-3p PPARGC1A 2.55218480823434 2.96135446816238e-51 -2.61634087589818 7.44821426380706e-32 mirMAP -0.313568601776736 6.61298144545941e-13 NA NA NA hsa-miR-200b-3p PPARGC1A 2.11744072703209 1.66710572104191e-43 -2.61634087589818 7.44821426380706e-32 mirMAP -0.324802263276939 2.39392476805595e-11 NA NA NA hsa-miR-200c-3p PPARGC1A 2.07038651806183 6.84613386286599e-51 -2.61634087589818 7.44821426380706e-32 mirMAP -0.427261934605626 9.16617706269459e-16 NA NA NA hsa-miR-21-3p PPARGC1A 2.17476065946878 5.15299442583591e-75 -2.61634087589818 7.44821426380706e-32 mirMAP -0.471733812015531 3.95513475007988e-15 NA NA NA hsa-miR-375 PPARGC1A 2.09893673049766 1.68351780396203e-16 -2.61634087589818 7.44821426380706e-32 miRanda -0.203571434468169 1.64340091775123e-11 NA NA NA hsa-miR-429 PPARGC1A 2.84108892259147 3.88520896426515e-64 -2.61634087589818 7.44821426380706e-32 PITA;miRanda;mirMAP;miRNATAP -0.347833839796999 7.71884969002976e-16 NA NA NA hsa-miR-141-3p PPARGC1B 2.99777540204168 1.26370498493024e-78 -1.46182968985053 1.35672112520709e-22 mirMAP -0.236237371615472 8.43149296242768e-16 NA NA NA hsa-miR-200a-3p PPARGC1B 2.55218480823434 2.96135446816238e-51 -1.46182968985053 1.35672112520709e-22 mirMAP -0.218993282047533 3.24643157595353e-14 NA NA NA hsa-miR-200a-5p PPARGC1B 2.58844508672328 1.79650654234569e-56 -1.46182968985053 1.35672112520709e-22 mirMAP -0.190449178899493 1.42565336700975e-10 NA NA NA hsa-miR-200b-3p PPARGC1B 2.11744072703209 1.66710572104191e-43 -1.46182968985053 1.35672112520709e-22 mirMAP -0.237691719808896 1.37382489867472e-13 NA NA NA hsa-miR-200c-3p PPARGC1B 2.07038651806183 6.84613386286599e-51 -1.46182968985053 1.35672112520709e-22 mirMAP -0.25650844094968 3.96925424783989e-13 NA NA NA hsa-miR-375 PPARGC1B 2.09893673049766 1.68351780396203e-16 -1.46182968985053 1.35672112520709e-22 miRNATAP -0.211280431451942 4.91018266636963e-27 NA NA NA hsa-miR-429 PPARGC1B 2.84108892259147 3.88520896426515e-64 -1.46182968985053 1.35672112520709e-22 mirMAP;miRNATAP -0.212664936283802 1.22814317425076e-13 NA NA NA hsa-miR-139-5p PPAT -3.25846663863766 2.62018989415003e-112 0.728850623878075 9.05399953673655e-18 miRanda -0.189206199925205 5.3639887883443e-28 NA NA NA hsa-miR-429 PPFIA2 2.84108892259147 3.88520896426515e-64 -1.3139448156162 6.93919420184591e-13 miRNATAP -0.325289260869798 2.64012305059493e-21 NA NA NA hsa-miR-335-5p PPFIA4 -2.61355235628987 2.6462884165886e-51 1.19255772298646 1.01953398017121e-09 miRNAWalker2_validate -0.250482849576487 4.70110601787345e-12 NA NA NA hsa-miR-141-3p PPFIBP1 2.99777540204168 1.26370498493024e-78 -0.738206527263465 1.91555687119124e-17 MirTarget -0.150400762269747 4.55624575032073e-19 NA NA NA hsa-miR-200a-3p PPFIBP1 2.55218480823434 2.96135446816238e-51 -0.738206527263465 1.91555687119124e-17 MirTarget -0.148029609494035 3.47561243575277e-19 NA NA NA hsa-miR-200b-3p PPFIBP1 2.11744072703209 1.66710572104191e-43 -0.738206527263465 1.91555687119124e-17 TargetScan -0.161248814152461 1.96569838965165e-18 NA NA NA hsa-miR-429 PPFIBP1 2.84108892259147 3.88520896426515e-64 -0.738206527263465 1.91555687119124e-17 miRanda -0.151135876340326 3.08637417661164e-20 NA NA NA hsa-miR-139-5p PPIH -3.25846663863766 2.62018989415003e-112 0.751590918609309 8.85420308423697e-26 miRanda -0.153524929484958 2.17418320165277e-25 NA NA NA hsa-miR-378a-5p PPM1E -2.43173551693523 1.44932837789175e-68 0.966379542690601 6.73593968365528e-06 MirTarget -0.127936403465887 0.00885275804847114 NA NA NA hsa-miR-182-5p PPM1F 2.36408084103818 2.60011457600281e-72 -1.01782278266201 2.82903184176664e-41 MirTarget -0.262803126797728 4.16356205070912e-49 NA NA NA hsa-miR-183-5p PPM1F 2.95681814393872 1.09965777344285e-92 -1.01782278266201 2.82903184176664e-41 mirMAP -0.262457502437526 1.41183633585487e-64 NA NA NA hsa-miR-200b-3p PPM1F 2.11744072703209 1.66710572104191e-43 -1.01782278266201 2.82903184176664e-41 MirTarget;TargetScan -0.141648458560111 1.15401038245452e-17 NA NA NA hsa-miR-200c-3p PPM1F 2.07038651806183 6.84613386286599e-51 -1.01782278266201 2.82903184176664e-41 miRNAWalker2_validate;MirTarget;miRNATAP -0.203540907484171 6.22609794635238e-30 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-21-3p PPM1F 2.17476065946878 5.15299442583591e-75 -1.01782278266201 2.82903184176664e-41 MirTarget -0.215546496466822 2.58092872531637e-26 NA NA NA hsa-miR-429 PPM1F 2.84108892259147 3.88520896426515e-64 -1.01782278266201 2.82903184176664e-41 MirTarget;PITA;miRanda;miRNATAP -0.148662104417378 3.4932847801028e-24 NA NA NA hsa-miR-96-5p PPM1F 3.24596558166606 1.92296159041707e-98 -1.01782278266201 2.82903184176664e-41 TargetScan;miRNATAP -0.2142898821372 2.87636643067719e-47 NA NA NA hsa-miR-141-3p PPM1K 2.99777540204168 1.26370498493024e-78 -0.767862143041894 8.32708135493473e-08 MirTarget -0.117756347106484 2.56336083071318e-05 NA NA NA hsa-miR-141-3p PPM1L 2.99777540204168 1.26370498493024e-78 -1.38023478402259 3.45760320629762e-23 MirTarget;TargetScan -0.192009566295454 2.80072569846837e-12 NA NA NA hsa-miR-200a-3p PPM1L 2.55218480823434 2.96135446816238e-51 -1.38023478402259 3.45760320629762e-23 MirTarget -0.170416821847245 2.89565432139411e-10 NA NA NA hsa-miR-21-5p PPM1L 2.32007501846389 3.08394781855554e-137 -1.38023478402259 3.45760320629762e-23 miRNAWalker2_validate -0.487717639137822 9.57244035693759e-30 NA NA NA hsa-miR-96-5p PPM1L 3.24596558166606 1.92296159041707e-98 -1.38023478402259 3.45760320629762e-23 TargetScan -0.189456023929872 1.26483874370178e-11 NA NA NA hsa-miR-182-5p PPP1R12B 2.36408084103818 2.60011457600281e-72 -2.23500813943069 2.60349931631869e-111 mirMAP -0.328514378693206 3.45083320099239e-36 NA NA NA hsa-miR-183-5p PPP1R12B 2.95681814393872 1.09965777344285e-92 -2.23500813943069 2.60349931631869e-111 mirMAP -0.358501043697495 4.09074674669211e-57 NA NA NA hsa-miR-200b-3p PPP1R12B 2.11744072703209 1.66710572104191e-43 -2.23500813943069 2.60349931631869e-111 TargetScan -0.301718429708338 1.19474770575743e-38 NA NA NA hsa-miR-429 PPP1R12B 2.84108892259147 3.88520896426515e-64 -2.23500813943069 2.60349931631869e-111 PITA;miRNATAP -0.315896651981479 1.26430419845607e-54 NA NA NA hsa-miR-21-5p PPP1R16B 2.32007501846389 3.08394781855554e-137 -2.17774746201998 4.8680300203316e-39 mirMAP -0.493117259284243 2.21457165700942e-20 NA NA NA hsa-miR-429 PPP1R16B 2.84108892259147 3.88520896426515e-64 -2.17774746201998 4.8680300203316e-39 miRanda;miRNATAP -0.374627260815214 7.73158132595859e-32 NA NA NA hsa-miR-21-3p PPP1R1A 2.17476065946878 5.15299442583591e-75 -4.76989601631288 8.28796248346058e-54 MirTarget -0.86131681768744 2.52896760934347e-24 NA NA NA hsa-miR-21-5p PPP1R3B 2.32007501846389 3.08394781855554e-137 -0.546041802350095 6.03122105265061e-08 MirTarget;miRNATAP -0.256215158731733 1.69463202861492e-16 NA NA NA hsa-miR-141-3p PPP1R3G 2.99777540204168 1.26370498493024e-78 -1.0988069165309 3.81547971781581e-15 TargetScan -0.303130547023889 6.51032067161583e-30 NA NA NA hsa-miR-17-3p PPP2CA 0.721439431208839 7.95900548819742e-10 0.355964216272682 1.3164574185057e-12 MirTarget -0.133330530645377 1.5958296816568e-20 NA NA NA hsa-miR-425-5p PPP2CB 0.719898949241718 6.01079610190374e-08 -0.508468028837195 3.29413468049735e-15 miRNAWalker2_validate -0.1434305833926 3.027811361313e-18 NA NA NA hsa-miR-590-3p PPP2CB 1.27438512890514 1.03164723481469e-23 -0.508468028837195 3.29413468049735e-15 miRanda -0.10511834935696 4.0251015210593e-09 NA NA NA hsa-miR-128-3p PPP2R1B 0.90296715955238 9.925204823863e-23 -1.24069690315388 3.45729939213988e-47 MirTarget -0.109583188561297 0.000963818534703709 NA NA NA hsa-miR-146b-5p PPP2R1B 0.631041661167954 6.20366593452965e-08 -1.24069690315388 3.45729939213988e-47 miRanda -0.141184532696467 1.00140046078863e-07 NA NA NA hsa-miR-15a-5p PPP2R1B 0.812445324157528 4.50263417099822e-20 -1.24069690315388 3.45729939213988e-47 MirTarget -0.195736754254626 1.30304715741401e-08 NA NA NA hsa-miR-200b-3p PPP2R1B 2.11744072703209 1.66710572104191e-43 -1.24069690315388 3.45729939213988e-47 MirTarget -0.190114683335312 5.20726875191601e-24 NA NA NA hsa-miR-200c-3p PPP2R1B 2.07038651806183 6.84613386286599e-51 -1.24069690315388 3.45729939213988e-47 MirTarget -0.226923946553815 2.68646974148231e-28 21248297 Western blotting showed that knockdown of miR-200c expression was associated with increased expression of PPP2R1B a subunit of protein phosphatase 2A which resulted in reduced expression of phospho-Akt esophageal cancer hsa-miR-30d-3p PPP2R1B 0.264544633563642 0.00755023189129747 -1.24069690315388 3.45729939213988e-47 mirMAP -0.157184793756038 6.17261426855798e-07 NA NA NA hsa-miR-429 PPP2R1B 2.84108892259147 3.88520896426515e-64 -1.24069690315388 3.45729939213988e-47 MirTarget;miRanda;miRNATAP -0.148415458438853 1.78268855237664e-18 NA NA NA hsa-miR-141-3p PPP2R2B 2.99777540204168 1.26370498493024e-78 -1.93953123840583 5.78989293907757e-30 TargetScan -0.315881073340513 5.36482191004776e-21 NA NA NA hsa-miR-224-5p PPP2R2C -2.22249420723892 1.07787949391113e-18 2.25419279038223 3.53879659770262e-10 mirMAP -0.103300631656607 0.0327111600518789 NA NA NA hsa-miR-107 PPP2R5A 0.678998026350662 2.56224148930538e-16 -0.271185658300753 0.000577998233135009 miRanda -0.116676163127242 0.000291888356596273 NA NA NA hsa-miR-455-5p PPP2R5A 0.284641224662773 0.0357572339594277 -0.271185658300753 0.000577998233135009 miRanda -0.148237717752069 5.19586125294051e-14 NA NA NA hsa-miR-132-3p PPP2R5E -0.0365213889238607 0.668598301088667 0.018935638230313 0.793647310855766 MirTarget -0.117209424280952 5.86934317627525e-05 NA NA NA hsa-miR-146b-5p PPP2R5E 0.631041661167954 6.20366593452965e-08 0.018935638230313 0.793647310855766 miRanda -0.108519433912314 2.38654321669596e-07 NA NA NA hsa-miR-181a-5p PPP2R5E 0.635863607630183 6.72486918157744e-11 0.018935638230313 0.793647310855766 MirTarget;mirMAP -0.172705968640064 4.32215395940648e-12 NA NA NA hsa-miR-181b-5p PPP2R5E 1.22749257795094 1.21998198830919e-27 0.018935638230313 0.793647310855766 MirTarget;mirMAP -0.122508311764402 6.82476700676191e-09 NA NA NA hsa-miR-181c-5p PPP2R5E 0.574847839298605 4.51287502066478e-07 0.018935638230313 0.793647310855766 MirTarget;mirMAP -0.122046895343518 1.35193024529625e-08 NA NA NA hsa-miR-361-5p PPP2R5E -0.0996867547900457 0.095428250126326 0.018935638230313 0.793647310855766 miRanda -0.362844376404808 1.47810752731031e-18 NA NA NA hsa-miR-374a-3p PPP2R5E 0.34122393953022 2.28714105382856e-05 0.018935638230313 0.793647310855766 MirTarget -0.108150800102799 0.000444740858970142 NA NA NA hsa-miR-374a-5p PPP2R5E -0.239709888246804 0.00309819667153627 0.018935638230313 0.793647310855766 mirMAP -0.175200740577251 9.34615884892216e-09 NA NA NA hsa-miR-381-3p PPP2R5E -1.28028930293369 1.61402949866141e-23 0.018935638230313 0.793647310855766 MirTarget;mirMAP -0.104778657482713 2.09043362809501e-08 NA NA NA hsa-miR-455-5p PPP2R5E 0.284641224662773 0.0357572339594277 0.018935638230313 0.793647310855766 miRanda -0.1463471269634 3.89164487655405e-16 NA NA NA hsa-miR-542-3p PPP2R5E 0.568822103820889 8.5699075257651e-07 0.018935638230313 0.793647310855766 miRanda -0.14687324447004 3.28141828349973e-12 NA NA NA hsa-let-7f-5p PPP3CA 0.12216148416417 0.221351291433294 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.102194254433793 0.00165189815382032 NA NA NA hsa-miR-106b-5p PPP3CA 1.22477789913175 2.31787213143326e-32 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.163746270795427 4.48730421523751e-08 NA NA NA hsa-miR-17-3p PPP3CA 0.721439431208839 7.95900548819742e-10 -0.544246415257643 5.77237427579346e-09 MirTarget -0.124078923715287 5.08318296663462e-06 NA NA NA hsa-miR-194-5p PPP3CA 0.467781870340114 1.0386810618625e-07 -0.544246415257643 5.77237427579346e-09 MirTarget -0.132376274530416 0.000303144003211118 NA NA NA hsa-miR-20a-5p PPP3CA 0.44979911120222 0.000602386964327228 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.110326267376209 6.81988772591416e-06 NA NA NA hsa-miR-21-5p PPP3CA 2.32007501846389 3.08394781855554e-137 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.171857455775929 3.70280677648987e-09 NA NA NA hsa-miR-340-5p PPP3CA 1.0857159627596 4.94471062546756e-24 -0.544246415257643 5.77237427579346e-09 mirMAP -0.176067551771713 1.43168876315375e-09 NA NA NA hsa-miR-361-5p PPP3CA -0.0996867547900457 0.095428250126326 -0.544246415257643 5.77237427579346e-09 miRanda -0.244052441662145 8.38230854446672e-06 NA NA NA hsa-miR-93-5p PPP3CA 1.01788600209314 1.24312921618126e-21 -0.544246415257643 5.77237427579346e-09 miRNATAP -0.162948227314112 3.15959129159339e-08 NA NA NA hsa-miR-107 PPP3CB 0.678998026350662 2.56224148930538e-16 -0.507852474824067 3.82558012937129e-19 miRanda -0.128823034238509 4.39638835494672e-08 NA NA NA hsa-miR-146b-5p PPP3CB 0.631041661167954 6.20366593452965e-08 -0.507852474824067 3.82558012937129e-19 miRanda -0.171198371090796 2.36585494803099e-25 NA NA NA hsa-miR-15a-5p PPP3CB 0.812445324157528 4.50263417099822e-20 -0.507852474824067 3.82558012937129e-19 miRNATAP -0.126089090631579 8.14069089424982e-09 NA NA NA hsa-miR-340-5p PPP3CB 1.0857159627596 4.94471062546756e-24 -0.507852474824067 3.82558012937129e-19 MirTarget -0.156446625862705 8.32036945224755e-19 NA NA NA hsa-miR-361-5p PPP3CB -0.0996867547900457 0.095428250126326 -0.507852474824067 3.82558012937129e-19 miRanda -0.218861370922051 6.00579314883281e-11 NA NA NA hsa-miR-101-3p PPP3R1 -0.126035286271986 0.145997832808138 -0.297052041419911 9.95522907099635e-08 miRNATAP -0.187171459954337 1.17776284425277e-17 NA NA NA hsa-miR-181c-5p PPP3R1 0.574847839298605 4.51287502066478e-07 -0.297052041419911 9.95522907099635e-08 MirTarget;miRNATAP -0.125950184238424 2.66954355100233e-14 NA NA NA hsa-miR-26a-5p PPP3R1 -0.481180084102235 1.82368246174758e-10 -0.297052041419911 9.95522907099635e-08 MirTarget;miRNATAP -0.15120972679612 1.94023722332139e-09 NA NA NA hsa-miR-30a-5p PPP3R1 -0.392489994825279 0.00954894667761676 -0.297052041419911 9.95522907099635e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.13382780475557 1.01801426792285e-27 NA NA NA hsa-miR-183-5p PPTC7 2.95681814393872 1.09965777344285e-92 -1.05971180235612 1.73465024589356e-16 mirMAP -0.123431299102511 7.29331704945218e-06 NA NA NA hsa-miR-429 PPTC7 2.84108892259147 3.88520896426515e-64 -1.05971180235612 1.73465024589356e-16 miRanda -0.166966758565232 1.03125849682846e-11 NA NA NA hsa-miR-139-5p PRC1 -3.25846663863766 2.62018989415003e-112 2.44025663063285 1.81066961016591e-69 miRanda -0.466203695071428 2.61201330655493e-58 NA NA NA hsa-miR-429 PRDM11 2.84108892259147 3.88520896426515e-64 -1.05097875615944 7.2819874301398e-24 miRNATAP -0.133021198442198 3.77682432370819e-11 NA NA NA hsa-miR-141-3p PRDM16 2.99777540204168 1.26370498493024e-78 -2.10183629954012 7.1878186105897e-40 mirMAP -0.455556653224769 2.57442829348823e-50 NA NA NA hsa-miR-182-5p PRDM16 2.36408084103818 2.60011457600281e-72 -2.10183629954012 7.1878186105897e-40 mirMAP;miRNATAP -0.346447530702107 6.68590364459399e-19 NA NA NA hsa-miR-200a-3p PRDM16 2.55218480823434 2.96135446816238e-51 -2.10183629954012 7.1878186105897e-40 mirMAP -0.375067410578859 1.43493425547548e-34 NA NA NA hsa-miR-200b-3p PRDM16 2.11744072703209 1.66710572104191e-43 -2.10183629954012 7.1878186105897e-40 MirTarget;TargetScan -0.385325298950015 2.32734489384361e-29 NA NA NA hsa-miR-200c-3p PRDM16 2.07038651806183 6.84613386286599e-51 -2.10183629954012 7.1878186105897e-40 MirTarget;miRNATAP -0.468792246552993 3.5803904073721e-36 NA NA NA hsa-miR-429 PRDM16 2.84108892259147 3.88520896426515e-64 -2.10183629954012 7.1878186105897e-40 MirTarget;PITA;miRanda;miRNATAP -0.370666147627594 3.25042185750124e-34 NA NA NA hsa-miR-96-5p PRDM16 3.24596558166606 1.92296159041707e-98 -2.10183629954012 7.1878186105897e-40 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.375161295447138 4.23223167754642e-32 NA NA NA hsa-miR-141-3p PRELP 2.99777540204168 1.26370498493024e-78 -2.43067905735392 8.0375135102859e-39 mirMAP -0.471786585742231 1.40436700415086e-38 NA NA NA hsa-miR-200a-3p PRELP 2.55218480823434 2.96135446816238e-51 -2.43067905735392 8.0375135102859e-39 mirMAP -0.400904112552462 1.1916252266967e-28 NA NA NA hsa-miR-21-5p PREPL 2.32007501846389 3.08394781855554e-137 -0.322293281183161 8.79993670730062e-06 miRNAWalker2_validate -0.216844720365857 9.91267695171153e-23 NA NA NA hsa-miR-125a-5p PRICKLE1 -0.635694700253268 3.6703235721638e-11 0.0303646488653939 0.804968550597215 miRanda -0.100102075572689 0.0215276812440828 NA NA NA hsa-miR-141-3p PRICKLE1 2.99777540204168 1.26370498493024e-78 0.0303646488653939 0.804968550597215 TargetScan -0.110970210955193 3.06180806587071e-06 NA NA NA hsa-miR-30a-5p PRICKLE1 -0.392489994825279 0.00954894667761676 0.0303646488653939 0.804968550597215 miRNATAP -0.136509847501526 7.9340765409784e-07 NA NA NA hsa-miR-30b-5p PRICKLE1 -0.46540603860146 2.4709940429591e-05 0.0303646488653939 0.804968550597215 mirMAP -0.181028075048876 1.82963092033562e-06 NA NA NA hsa-miR-30c-5p PRICKLE1 -0.393222674580066 8.06961465717306e-05 0.0303646488653939 0.804968550597215 miRNATAP -0.185707414237874 1.02763767207438e-05 NA NA NA hsa-miR-30d-5p PRICKLE1 -0.247082219011045 0.00406717930063148 0.0303646488653939 0.804968550597215 miRNATAP -0.25925039080586 1.16398766251352e-07 NA NA NA hsa-miR-338-3p PRICKLE1 0.0799903526884966 0.575137668326679 0.0303646488653939 0.804968550597215 miRanda -0.272922631390263 3.10345977041188e-21 NA NA NA hsa-let-7a-3p PRICKLE2 0.466622567891891 3.70886257943079e-07 -1.41551101306739 1.76700405075257e-30 mirMAP -0.246014128854383 2.22205350393919e-07 NA NA NA hsa-let-7f-1-3p PRICKLE2 0.37532726250321 0.00156021688753682 -1.41551101306739 1.76700405075257e-30 mirMAP -0.188710377572271 4.19141267701058e-07 NA NA NA hsa-miR-130b-5p PRICKLE2 1.0573161199584 2.55177349228739e-12 -1.41551101306739 1.76700405075257e-30 mirMAP -0.285840335314836 1.14671532560812e-24 NA NA NA hsa-miR-132-3p PRICKLE2 -0.0365213889238607 0.668598301088667 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.13545645775625 0.00901118165664025 NA NA NA hsa-miR-146a-5p PRICKLE2 0.102405752365098 0.486975378688068 -1.41551101306739 1.76700405075257e-30 mirMAP -0.22636521497307 1.32581685728342e-14 NA NA NA hsa-miR-148a-3p PRICKLE2 0.706969798912638 5.52538085480485e-09 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.136596669407525 0.000140359936538593 NA NA NA hsa-miR-148a-5p PRICKLE2 0.572692271754695 2.14306251522796e-06 -1.41551101306739 1.76700405075257e-30 mirMAP -0.225124369392631 3.42801988361129e-10 NA NA NA hsa-miR-148b-3p PRICKLE2 1.0552576751879 1.6679285705231e-29 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.368462111806635 1.62423559573341e-16 NA NA NA hsa-miR-15b-3p PRICKLE2 1.12898579025388 1.18050912917317e-14 -1.41551101306739 1.76700405075257e-30 mirMAP -0.350402182346711 3.40989651980756e-35 NA NA NA hsa-miR-16-2-3p PRICKLE2 0.286355254959005 0.0256946046884474 -1.41551101306739 1.76700405075257e-30 mirMAP -0.331538116676408 5.09067457660196e-23 NA NA NA hsa-miR-181a-5p PRICKLE2 0.635863607630183 6.72486918157744e-11 -1.41551101306739 1.76700405075257e-30 mirMAP;miRNATAP -0.249054061695165 2.07379976240012e-08 NA NA NA hsa-miR-181b-5p PRICKLE2 1.22749257795094 1.21998198830919e-27 -1.41551101306739 1.76700405075257e-30 mirMAP;miRNATAP -0.32240643127462 3.08135600536136e-18 NA NA NA hsa-miR-181c-5p PRICKLE2 0.574847839298605 4.51287502066478e-07 -1.41551101306739 1.76700405075257e-30 mirMAP;miRNATAP -0.169715036124902 9.09731846427341e-06 NA NA NA hsa-miR-182-5p PRICKLE2 2.36408084103818 2.60011457600281e-72 -1.41551101306739 1.76700405075257e-30 MirTarget -0.183980281487538 1.18712295456704e-09 NA NA NA hsa-miR-186-5p PRICKLE2 -0.426987301460247 1.04129380549315e-05 -1.41551101306739 1.76700405075257e-30 MirTarget -0.315192987077069 1.89815838419289e-12 NA NA NA hsa-miR-18a-5p PRICKLE2 0.969066793715868 1.69069796425892e-08 -1.41551101306739 1.76700405075257e-30 MirTarget -0.387730469036141 3.85619154280423e-61 NA NA NA hsa-miR-194-5p PRICKLE2 0.467781870340114 1.0386810618625e-07 -1.41551101306739 1.76700405075257e-30 miRNATAP -0.291494776067705 3.80032824411756e-09 NA NA NA hsa-miR-197-3p PRICKLE2 -0.526589453596294 3.61594599437195e-06 -1.41551101306739 1.76700405075257e-30 mirMAP -0.259951469488209 8.6048620172375e-12 NA NA NA hsa-miR-19a-3p PRICKLE2 0.817507952171848 3.76285090469625e-08 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.402369518872812 5.04349600060003e-48 NA NA NA hsa-miR-19b-3p PRICKLE2 0.139124391010031 0.255658553872934 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.400025342580155 8.2019109465105e-31 NA NA NA hsa-miR-21-5p PRICKLE2 2.32007501846389 3.08394781855554e-137 -1.41551101306739 1.76700405075257e-30 miRNAWalker2_validate;MirTarget -0.342742077988917 1.89622326605409e-18 NA NA NA hsa-miR-212-3p PRICKLE2 0.24081906669865 0.0571447155653209 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.180712852119462 2.58202184300501e-07 NA NA NA hsa-miR-27a-3p PRICKLE2 0.388496361379095 1.42373532086331e-05 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.278229845269387 1.14515707500582e-08 NA NA NA hsa-miR-29b-3p PRICKLE2 0.438847962603729 6.46722433236121e-05 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.230464863795446 6.02712611151921e-09 NA NA NA hsa-miR-320b PRICKLE2 0.412787504747938 0.00113457276903985 -1.41551101306739 1.76700405075257e-30 mirMAP -0.227440830315089 3.84313880753253e-11 NA NA NA hsa-miR-330-3p PRICKLE2 0.432728362037032 0.00041335506960812 -1.41551101306739 1.76700405075257e-30 MirTarget -0.191111976333898 1.16789091807142e-07 NA NA NA hsa-miR-330-5p PRICKLE2 0.626063225953928 3.42215028606779e-09 -1.41551101306739 1.76700405075257e-30 miRanda;miRNATAP -0.343203715809295 2.05881181519595e-17 NA NA NA hsa-miR-33a-5p PRICKLE2 1.35185127289399 9.80509199125785e-12 -1.41551101306739 1.76700405075257e-30 MirTarget -0.202816748660763 1.08415799126293e-20 NA NA NA hsa-miR-361-5p PRICKLE2 -0.0996867547900457 0.095428250126326 -1.41551101306739 1.76700405075257e-30 MirTarget;PITA;miRanda;miRNATAP -0.423190675531575 1.14669419541242e-08 NA NA NA hsa-miR-362-5p PRICKLE2 -0.248676340901797 0.0726089851456282 -1.41551101306739 1.76700405075257e-30 mirMAP -0.277240440642943 4.36846092164439e-19 NA NA NA hsa-miR-374a-3p PRICKLE2 0.34122393953022 2.28714105382856e-05 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.294917743521684 5.68270721710634e-08 NA NA NA hsa-miR-429 PRICKLE2 2.84108892259147 3.88520896426515e-64 -1.41551101306739 1.76700405075257e-30 miRNATAP -0.259740006651794 1.66095895526273e-28 NA NA NA hsa-miR-484 PRICKLE2 0.349444060004737 0.00154491249625173 -1.41551101306739 1.76700405075257e-30 miRNATAP -0.21226644714009 8.08847112830986e-08 NA NA NA hsa-miR-500a-5p PRICKLE2 0.209805801129289 0.119177819862398 -1.41551101306739 1.76700405075257e-30 mirMAP -0.344234333311061 7.17467559930117e-27 NA NA NA hsa-miR-576-5p PRICKLE2 0.0649387707567879 0.588791966096287 -1.41551101306739 1.76700405075257e-30 mirMAP -0.318889040233355 6.40864949657442e-19 NA NA NA hsa-miR-589-3p PRICKLE2 0.0263457630961427 0.866577983997705 -1.41551101306739 1.76700405075257e-30 MirTarget -0.131279359595792 4.29454967061397e-06 NA NA NA hsa-miR-589-5p PRICKLE2 0.367182541239722 1.67804815542873e-05 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.410788762794066 5.39765560115147e-16 NA NA NA hsa-miR-590-3p PRICKLE2 1.27438512890514 1.03164723481469e-23 -1.41551101306739 1.76700405075257e-30 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.428246782039215 4.12749671901844e-37 NA NA NA hsa-miR-590-5p PRICKLE2 0.746515607868274 8.51300479640125e-09 -1.41551101306739 1.76700405075257e-30 MirTarget;PITA;miRanda -0.400059229125334 2.18643891880232e-35 NA NA NA hsa-miR-629-3p PRICKLE2 1.25035919247365 3.91361135469024e-14 -1.41551101306739 1.76700405075257e-30 MirTarget -0.17392475751545 7.91638698760279e-11 NA NA NA hsa-miR-7-1-3p PRICKLE2 0.686579567507582 1.20731554448806e-07 -1.41551101306739 1.76700405075257e-30 MirTarget -0.19024658377573 1.21829464745801e-08 NA NA NA hsa-miR-96-5p PRIMA1 3.24596558166606 1.92296159041707e-98 -2.48245555663538 2.0100125412497e-35 MirTarget;TargetScan;miRNATAP -0.467433369784863 6.49316475253012e-32 NA NA NA hsa-miR-182-5p PRKAA1 2.36408084103818 2.60011457600281e-72 -0.889722997110138 6.68547349344403e-22 MirTarget -0.12957259010959 7.74120097344211e-09 NA NA NA hsa-miR-429 PRKAA1 2.84108892259147 3.88520896426515e-64 -0.889722997110138 6.68547349344403e-22 miRNATAP -0.141667891084818 1.10952877434855e-15 NA NA NA hsa-miR-21-3p PRKAA2 2.17476065946878 5.15299442583591e-75 -0.579847549865762 0.0120328308442779 mirMAP -0.257680881978514 2.16873974422669e-05 NA NA NA hsa-miR-21-5p PRKAB2 2.32007501846389 3.08394781855554e-137 -0.370101377546258 1.14603562385171e-06 miRNAWalker2_validate -0.110118016164516 3.47489548105212e-06 NA NA NA hsa-miR-141-3p PRKACB 2.99777540204168 1.26370498493024e-78 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 NA NA NA hsa-miR-17-5p PRKACB 0.599531757298529 1.07318660415906e-05 -0.383846400368397 0.0117591306589187 TargetScan -0.167470485926017 1.11326049159611e-05 NA NA NA hsa-miR-18a-5p PRKACB 0.969066793715868 1.69069796425892e-08 -0.383846400368397 0.0117591306589187 miRNATAP -0.109828861303179 0.000270889162356874 NA NA NA hsa-miR-19a-3p PRKACB 0.817507952171848 3.76285090469625e-08 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.144307019920445 3.41593280940585e-05 NA NA NA hsa-miR-19b-3p PRKACB 0.139124391010031 0.255658553872934 -0.383846400368397 0.0117591306589187 miRNAWalker2_validate;MirTarget;miRNATAP -0.13474256019019 0.00164169207970928 NA NA NA hsa-miR-200b-3p PRKACB 2.11744072703209 1.66710572104191e-43 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 NA NA NA hsa-miR-200c-3p PRKACB 2.07038651806183 6.84613386286599e-51 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 NA NA NA hsa-miR-30d-3p PRKACB 0.264544633563642 0.00755023189129747 -0.383846400368397 0.0117591306589187 mirMAP -0.251818481172515 1.82407867076559e-06 NA NA NA hsa-miR-340-5p PRKACB 1.0857159627596 4.94471062546756e-24 -0.383846400368397 0.0117591306589187 mirMAP -0.151842813986032 0.001373090709035 NA NA NA hsa-miR-361-5p PRKACB -0.0996867547900457 0.095428250126326 -0.383846400368397 0.0117591306589187 miRanda -0.31917046064862 0.000326749716630808 NA NA NA hsa-miR-362-5p PRKACB -0.248676340901797 0.0726089851456282 -0.383846400368397 0.0117591306589187 PITA -0.175108655019306 3.25359783331258e-06 NA NA NA hsa-miR-532-5p PRKACB 0.0386976222860582 0.682018574136515 -0.383846400368397 0.0117591306589187 PITA -0.167904290632964 0.00255889279358267 NA NA NA hsa-miR-93-5p PRKACB 1.01788600209314 1.24312921618126e-21 -0.383846400368397 0.0117591306589187 miRNAWalker2_validate -0.337877597223658 9.95580809015501e-13 NA NA NA hsa-miR-21-5p PRKAR2A 2.32007501846389 3.08394781855554e-137 -0.849497621481062 3.89379966434713e-09 mirMAP -0.342627756886755 1.81049457969324e-14 NA NA NA hsa-miR-200b-3p PRKAR2B 2.11744072703209 1.66710572104191e-43 -2.21081590198765 1.60222507436243e-42 TargetScan -0.280997010338504 3.04124526480141e-15 NA NA NA hsa-miR-200c-3p PRKAR2B 2.07038651806183 6.84613386286599e-51 -2.21081590198765 1.60222507436243e-42 miRNATAP -0.292941274401131 8.32765818000856e-14 NA NA NA hsa-miR-429 PRKAR2B 2.84108892259147 3.88520896426515e-64 -2.21081590198765 1.60222507436243e-42 PITA;miRanda;miRNATAP -0.297037447890531 4.91028637474137e-21 NA NA NA hsa-miR-181b-5p PRKCA 1.22749257795094 1.21998198830919e-27 -1.70723657875247 1.7688165305473e-34 mirMAP -0.11742885805708 0.0062191009662321 NA NA NA hsa-miR-181c-5p PRKCA 0.574847839298605 4.51287502066478e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.151937361609795 0.00048559417186175 NA NA NA hsa-miR-183-5p PRKCA 2.95681814393872 1.09965777344285e-92 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.382401275003301 4.39521361355191e-39 NA NA NA hsa-miR-193b-3p PRKCA -0.0550374855074773 0.65382485898551 -1.70723657875247 1.7688165305473e-34 miRNAWalker2_validate -0.158591304154604 9.61914010087921e-05 NA NA NA hsa-miR-194-5p PRKCA 0.467781870340114 1.0386810618625e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.194734764385864 0.000579018161354159 NA NA NA hsa-miR-200b-3p PRKCA 2.11744072703209 1.66710572104191e-43 -1.70723657875247 1.7688165305473e-34 TargetScan -0.338107140907763 7.43601898887161e-30 NA NA NA hsa-miR-200c-3p PRKCA 2.07038651806183 6.84613386286599e-51 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.384868851727468 4.79014422420278e-32 NA NA NA hsa-miR-29b-2-5p PRKCA -0.263499971180298 0.0400001755611965 -1.70723657875247 1.7688165305473e-34 mirMAP -0.365220324605892 6.60788568306249e-22 NA NA NA hsa-miR-30d-3p PRKCA 0.264544633563642 0.00755023189129747 -1.70723657875247 1.7688165305473e-34 mirMAP -0.185045137833304 0.000246654172160224 NA NA NA hsa-miR-339-5p PRKCA -0.211548290465418 0.0685885445822389 -1.70723657875247 1.7688165305473e-34 mirMAP -0.116903398908303 0.00661066095178211 NA NA NA hsa-miR-340-5p PRKCA 1.0857159627596 4.94471062546756e-24 -1.70723657875247 1.7688165305473e-34 mirMAP -0.157880969288124 0.000482930053726641 NA NA NA hsa-miR-375 PRKCA 2.09893673049766 1.68351780396203e-16 -1.70723657875247 1.7688165305473e-34 miRNAWalker2_validate -0.240131861837491 2.29799527522168e-39 NA NA NA hsa-miR-429 PRKCA 2.84108892259147 3.88520896426515e-64 -1.70723657875247 1.7688165305473e-34 miRanda;miRNATAP -0.302006017947741 7.14515269636082e-30 NA NA NA hsa-miR-141-5p PRKCB 2.38411349683216 4.56310582620282e-58 -0.447147877250759 0.0168049140120418 mirMAP -0.127187131565152 0.00154757873879663 NA NA NA hsa-miR-200b-3p PRKCB 2.11744072703209 1.66710572104191e-43 -0.447147877250759 0.0168049140120418 MirTarget -0.185811618752792 2.61023291805883e-06 NA NA NA hsa-miR-200c-3p PRKCB 2.07038651806183 6.84613386286599e-51 -0.447147877250759 0.0168049140120418 MirTarget;miRNATAP -0.190171510726694 1.24294313881003e-05 NA NA NA hsa-miR-29b-2-5p PRKCB -0.263499971180298 0.0400001755611965 -0.447147877250759 0.0168049140120418 mirMAP -0.248738713275143 5.96583916655133e-07 NA NA NA hsa-miR-30b-5p PRKCB -0.46540603860146 2.4709940429591e-05 -0.447147877250759 0.0168049140120418 mirMAP -0.181899501701348 0.00172429854651836 NA NA NA hsa-miR-30c-5p PRKCB -0.393222674580066 8.06961465717306e-05 -0.447147877250759 0.0168049140120418 mirMAP -0.266676621567604 3.26692465594906e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.264544633563642 0.00755023189129747 -0.447147877250759 0.0168049140120418 mirMAP -0.176195796338334 0.00676988213351706 NA NA NA hsa-miR-338-3p PRKCB 0.0799903526884966 0.575137668326679 -0.447147877250759 0.0168049140120418 miRanda -0.216031823790678 1.44429456470486e-06 NA NA NA hsa-miR-429 PRKCB 2.84108892259147 3.88520896426515e-64 -0.447147877250759 0.0168049140120418 MirTarget;miRanda;miRNATAP -0.177108211107202 5.14864677602474e-07 NA NA NA hsa-miR-484 PRKCB 0.349444060004737 0.00154491249625173 -0.447147877250759 0.0168049140120418 MirTarget;miRNATAP -0.147301231927914 0.0114084132678022 NA NA NA hsa-miR-664a-3p PRKCB -0.237699857923843 0.0197071390183375 -0.447147877250759 0.0168049140120418 mirMAP -0.30918523276408 8.70938453871888e-07 NA NA NA hsa-miR-141-3p PRKCE 2.99777540204168 1.26370498493024e-78 -0.665119336429135 4.20185755136611e-11 TargetScan;miRNATAP -0.126161525544588 1.2962263510062e-10 NA NA NA hsa-miR-21-5p PRKCE 2.32007501846389 3.08394781855554e-137 -0.665119336429135 4.20185755136611e-11 miRNAWalker2_validate -0.277567939130377 4.73115836338224e-19 NA NA NA hsa-miR-21-3p PRKCH 2.17476065946878 5.15299442583591e-75 -0.682659432619502 6.17589721625978e-17 MirTarget -0.115175194414601 1.20953328800041e-07 NA NA NA hsa-miR-429 PRKCH 2.84108892259147 3.88520896426515e-64 -0.682659432619502 6.17589721625978e-17 miRanda -0.115800823211256 8.9878194709367e-14 NA NA NA hsa-miR-429 PRKCQ 2.84108892259147 3.88520896426515e-64 -0.699033121447314 0.000628432051813325 miRanda -0.109676627303439 0.00473642160883843 NA NA NA hsa-miR-141-3p PRKD1 2.99777540204168 1.26370498493024e-78 -1.79496662198383 1.13842611279171e-44 MirTarget;TargetScan -0.406292393970467 1.52337242004486e-62 NA NA NA hsa-miR-182-5p PRKD1 2.36408084103818 2.60011457600281e-72 -1.79496662198383 1.13842611279171e-44 miRNATAP -0.384269202046534 1.72211725771539e-35 NA NA NA hsa-miR-200a-3p PRKD1 2.55218480823434 2.96135446816238e-51 -1.79496662198383 1.13842611279171e-44 MirTarget -0.349454946030932 1.34010425652452e-46 NA NA NA hsa-miR-21-3p PRKD1 2.17476065946878 5.15299442583591e-75 -1.79496662198383 1.13842611279171e-44 MirTarget -0.221071857346683 3.81709449805407e-10 NA NA NA hsa-miR-375 PRKD1 2.09893673049766 1.68351780396203e-16 -1.79496662198383 1.13842611279171e-44 miRanda;miRNATAP -0.105612854713499 2.4604331853682e-09 NA NA NA hsa-miR-429 PRKD3 2.84108892259147 3.88520896426515e-64 -0.996801497929017 1.76852596058297e-20 miRanda;miRNATAP -0.166392202875948 4.70603935212667e-16 NA NA NA hsa-miR-200b-3p PRKG1 2.11744072703209 1.66710572104191e-43 -1.38365839435521 1.52547149627446e-11 TargetScan -0.353809684521588 3.10054322182671e-16 NA NA NA hsa-miR-200c-3p PRKG1 2.07038651806183 6.84613386286599e-51 -1.38365839435521 1.52547149627446e-11 miRNATAP -0.393121784158909 1.48074207227863e-16 NA NA NA hsa-miR-21-5p PRKG1 2.32007501846389 3.08394781855554e-137 -1.38365839435521 1.52547149627446e-11 mirMAP -0.291412972335893 6.26831369404863e-06 NA NA NA hsa-miR-429 PRKG1 2.84108892259147 3.88520896426515e-64 -1.38365839435521 1.52547149627446e-11 miRNATAP -0.345734793816307 2.81190512499205e-19 NA NA NA hsa-miR-96-5p PRKG1 3.24596558166606 1.92296159041707e-98 -1.38365839435521 1.52547149627446e-11 miRNATAP -0.308727050101338 2.37342172956195e-14 NA NA NA hsa-miR-429 PRKG2 2.84108892259147 3.88520896426515e-64 -1.66862486504124 4.52032610471578e-14 miRanda -0.33435827047053 1.40610368171573e-15 NA NA NA hsa-miR-182-5p PRKX 2.36408084103818 2.60011457600281e-72 -0.32229806441307 0.0153896096972611 mirMAP -0.175194994974604 2.67502751484288e-08 NA NA NA hsa-miR-29b-3p PRKX 0.438847962603729 6.46722433236121e-05 -0.32229806441307 0.0153896096972611 mirMAP -0.120330213613139 0.0037387071410825 NA NA NA hsa-miR-29c-3p PRKX -0.0652732378039769 0.563774115756922 -0.32229806441307 0.0153896096972611 mirMAP -0.38827959473025 7.47361121556913e-23 NA NA NA hsa-miR-375 PRKX 2.09893673049766 1.68351780396203e-16 -0.32229806441307 0.0153896096972611 miRNAWalker2_validate;miRanda -0.207392873270567 7.07421795114455e-35 NA NA NA hsa-miR-625-3p PRKX 0.0779480073849017 0.444334811113011 -0.32229806441307 0.0153896096972611 mirMAP -0.146145038207053 0.00114969241015916 NA NA NA hsa-miR-144-5p PRLR -2.75914786146772 1.55794225315972e-50 1.27351378761725 5.27607801731441e-13 mirMAP -0.236248227916033 1.47242221155932e-14 NA NA NA hsa-miR-429 PRNP 2.84108892259147 3.88520896426515e-64 -1.54852887644859 6.53160447249406e-42 miRNATAP -0.202267498223148 1.14012231507718e-19 NA NA NA hsa-miR-210-3p PROK1 2.38367203491819 3.73261999106754e-22 -2.56640398091313 6.56602238617162e-24 MirTarget -0.289647137539859 9.23243838567811e-17 NA NA NA hsa-miR-375 PROS1 2.09893673049766 1.68351780396203e-16 -2.19756827330153 2.03994096685545e-66 miRanda -0.152079888688611 2.61155429473572e-17 NA NA NA hsa-miR-141-5p PROX1 2.38411349683216 4.56310582620282e-58 -3.30249132498998 3.55828560245591e-41 miRNATAP -0.504988784349063 1.43662151026561e-20 NA NA NA hsa-miR-200b-3p PROX1 2.11744072703209 1.66710572104191e-43 -3.30249132498998 3.55828560245591e-41 TargetScan -0.483046219226898 2.46808862172114e-19 NA NA NA hsa-miR-429 PROX1 2.84108892259147 3.88520896426515e-64 -3.30249132498998 3.55828560245591e-41 miRanda -0.488837619799414 1.05466577053042e-24 NA NA NA hsa-miR-139-5p PRPF3 -3.25846663863766 2.62018989415003e-112 0.544425138830736 4.16731348271003e-16 miRanda -0.128454382406408 6.21806424977789e-21 NA NA NA hsa-miR-429 PRPH2 2.84108892259147 3.88520896426515e-64 -1.00026750289301 1.82973847144166e-09 miRNATAP -0.245135693571156 5.08669446194315e-15 NA NA NA hsa-miR-139-5p PRR11 -3.25846663863766 2.62018989415003e-112 1.79812089651113 1.3868680626388e-14 miRanda -0.430276262769373 2.48675647999243e-19 NA NA NA hsa-miR-337-3p PRR12 -2.14274617598363 2.70942896809734e-43 0.511273185427386 3.42902241254277e-12 MirTarget;PITA -0.114083671183095 1.00028280621614e-13 NA NA NA hsa-miR-139-5p PRR15 -3.25846663863766 2.62018989415003e-112 2.15801611312615 1.85407919829463e-17 miRanda -0.22371110771187 2.59235002933701e-05 NA NA NA hsa-miR-486-5p PRR15 -3.87258704301474 1.22658629378451e-80 2.15801611312615 1.85407919829463e-17 miRanda -0.26181143135381 1.7532631879007e-11 NA NA NA hsa-miR-335-5p PRR15L -2.61355235628987 2.6462884165886e-51 2.19570182890655 7.94251878490466e-32 miRNAWalker2_validate -0.254388558978361 1.01641705139623e-12 NA NA NA hsa-miR-335-5p PRR19 -2.61355235628987 2.6462884165886e-51 2.20486786453038 4.14359604912475e-87 miRNATAP -0.269792126506456 5.08841842513497e-34 NA NA NA hsa-miR-429 PRR5L 2.84108892259147 3.88520896426515e-64 0.156480970366573 0.0937632013477339 miRNATAP -0.10664635872772 1.14966398486531e-09 NA NA NA hsa-miR-182-5p PRRG1 2.36408084103818 2.60011457600281e-72 -1.40942208326118 1.13599674198685e-29 mirMAP -0.333676126127651 3.25028573853303e-29 NA NA NA hsa-miR-21-5p PRRG1 2.32007501846389 3.08394781855554e-137 -1.40942208326118 1.13599674198685e-29 MirTarget -0.320684464127628 5.47382623869741e-16 NA NA NA hsa-miR-96-5p PRRG1 3.24596558166606 1.92296159041707e-98 -1.40942208326118 1.13599674198685e-29 TargetScan -0.28404047823526 8.81442227829623e-31 NA NA NA hsa-miR-335-5p PRRG2 -2.61355235628987 2.6462884165886e-51 1.33214545033494 2.85523691368208e-25 miRNAWalker2_validate -0.189672330214451 4.34812454777655e-15 NA NA NA hsa-miR-139-5p PRRG4 -3.25846663863766 2.62018989415003e-112 0.868288420102119 4.18293154622901e-14 mirMAP -0.170692934441546 6.2019286263206e-13 NA NA NA hsa-miR-139-5p PRRT2 -3.25846663863766 2.62018989415003e-112 0.987440728520368 5.22122173021584e-09 miRanda -0.114145843896867 0.0011466577772889 NA NA NA hsa-miR-10b-5p PRRT3 -2.10996264627796 7.36811595736367e-72 1.76563461521472 1.52595554805261e-32 MirTarget;miRNATAP -0.215031264656143 1.56334606479507e-07 NA NA NA hsa-miR-429 PRRT4 2.84108892259147 3.88520896426515e-64 -3.70268824131632 3.89686832146021e-54 miRNATAP -0.540349978291137 6.40291620673217e-31 NA NA NA hsa-miR-96-5p PRRX1 3.24596558166606 1.92296159041707e-98 -0.415469707652431 0.00171921310151227 MirTarget;TargetScan -0.220128703693586 1.25892229082806e-17 NA NA NA hsa-miR-452-5p PRSS23 -2.48486455572568 1.24430987974325e-33 0.5826100436921 4.91406099524118e-05 MirTarget -0.200348610730139 6.39140826848555e-19 NA NA NA hsa-miR-335-5p PRSS53 -2.61355235628987 2.6462884165886e-51 0.419526206438073 0.000241207460825614 miRNAWalker2_validate -0.141825021205454 1.61840452357629e-11 NA NA NA hsa-miR-335-5p PRSS8 -2.61355235628987 2.6462884165886e-51 2.44555554580136 1.82961259844624e-40 miRNAWalker2_validate -0.262727799987176 1.14498013454728e-13 NA NA NA hsa-miR-486-5p PRSS8 -3.87258704301474 1.22658629378451e-80 2.44555554580136 1.82961259844624e-40 miRanda -0.35435327922703 1.68680911376375e-36 NA NA NA hsa-miR-141-3p PRTG 2.99777540204168 1.26370498493024e-78 -1.2107463479419 1.82371391116989e-11 MirTarget;miRNATAP -0.292350893088517 4.6146675982696e-17 NA NA NA hsa-miR-182-5p PRTG 2.36408084103818 2.60011457600281e-72 -1.2107463479419 1.82371391116989e-11 miRNATAP -0.139002482320087 0.00137664070808595 NA NA NA hsa-miR-200a-3p PRTG 2.55218480823434 2.96135446816238e-51 -1.2107463479419 1.82371391116989e-11 MirTarget;miRNATAP -0.282738044631308 1.32311244906525e-16 NA NA NA hsa-miR-200c-3p PRTG 2.07038651806183 6.84613386286599e-51 -1.2107463479419 1.82371391116989e-11 miRNATAP -0.293129535070471 3.14708792150803e-12 NA NA NA hsa-miR-429 PRTG 2.84108892259147 3.88520896426515e-64 -1.2107463479419 1.82371391116989e-11 miRanda;miRNATAP -0.313822372339115 1.5099214383942e-20 NA NA NA hsa-miR-96-5p PRTG 3.24596558166606 1.92296159041707e-98 -1.2107463479419 1.82371391116989e-11 MirTarget;miRNATAP -0.234037606396557 5.55265550964717e-11 NA NA NA hsa-miR-182-5p PRUNE2 2.36408084103818 2.60011457600281e-72 -1.97062029433689 9.76121489238308e-34 miRNATAP -0.367835635018595 1.30717746199041e-20 NA NA NA hsa-miR-183-5p PRUNE2 2.95681814393872 1.09965777344285e-92 -1.97062029433689 9.76121489238308e-34 miRNATAP -0.355341358365834 1.62373301790963e-24 NA NA NA hsa-miR-196a-5p PRUNE2 2.33423717464504 3.646557504928e-18 -1.97062029433689 9.76121489238308e-34 miRNAWalker2_validate -0.121896739002859 6.56122820692736e-09 NA NA NA hsa-miR-429 PRUNE2 2.84108892259147 3.88520896426515e-64 -1.97062029433689 9.76121489238308e-34 miRNATAP -0.31110356848807 2.83864274459476e-23 NA NA NA hsa-miR-182-5p PRX 2.36408084103818 2.60011457600281e-72 -1.16222313459438 1.53148964204581e-20 mirMAP -0.131458238493179 1.5705569271848e-05 NA NA NA hsa-miR-429 PRX 2.84108892259147 3.88520896426515e-64 -1.16222313459438 1.53148964204581e-20 miRNATAP -0.140369031313188 5.6337598739757e-09 NA NA NA hsa-miR-96-5p PRX 3.24596558166606 1.92296159041707e-98 -1.16222313459438 1.53148964204581e-20 mirMAP -0.17105904553565 8.5750408125208e-12 NA NA NA hsa-miR-200b-3p PSAT1 2.11744072703209 1.66710572104191e-43 -1.10795238445819 2.31514055686743e-05 MirTarget;TargetScan -0.245468915718648 1.01063670576654e-05 NA NA NA hsa-miR-200c-3p PSAT1 2.07038651806183 6.84613386286599e-51 -1.10795238445819 2.31514055686743e-05 MirTarget -0.182682310425925 0.00289612417839974 NA NA NA hsa-miR-486-5p PSD -3.87258704301474 1.22658629378451e-80 1.51825866075637 1.61568684835317e-19 miRanda;miRNATAP -0.130167581658553 5.48249395871635e-07 NA NA NA hsa-miR-144-5p PSD3 -2.75914786146772 1.55794225315972e-50 0.0825927941452509 0.668950460041898 MirTarget;mirMAP -0.101720010814816 0.00247923729713253 NA NA NA hsa-miR-452-5p PSD3 -2.48486455572568 1.24430987974325e-33 0.0825927941452509 0.668950460041898 mirMAP -0.16276531115563 1.10809695129555e-07 NA NA NA hsa-miR-361-5p PSEN1 -0.0996867547900457 0.095428250126326 0.143451287676788 0.00532754242361059 miRanda -0.201624103764595 1.00858341777568e-11 NA NA NA hsa-miR-99a-5p PSMA2 -2.25079447371102 1.14086813185885e-54 0.431025633563729 3.06930518476285e-15 miRNAWalker2_validate -0.116074831133107 3.18859611147418e-22 NA NA NA hsa-miR-139-5p PSMA5 -3.25846663863766 2.62018989415003e-112 0.930836774386664 3.36212026113688e-46 MirTarget -0.199551268638563 1.50849596850871e-50 NA NA NA hsa-miR-139-5p PSMB10 -3.25846663863766 2.62018989415003e-112 0.742545518037804 1.03200184607657e-11 miRanda -0.102971937692596 5.54147646316044e-06 NA NA NA hsa-miR-139-5p PSMD10 -3.25846663863766 2.62018989415003e-112 0.479721603267899 1.06607514009124e-19 miRanda -0.129816687057911 3.46949224867082e-34 NA NA NA hsa-miR-10b-5p PSMD11 -2.10996264627796 7.36811595736367e-72 0.635313529077501 1.25430592125343e-16 miRNAWalker2_validate -0.181757295091111 4.9269266594795e-19 NA NA NA hsa-miR-10b-5p PSMD13 -2.10996264627796 7.36811595736367e-72 0.460103235440442 3.06624280899273e-14 miRNAWalker2_validate -0.148413621344022 1.71341805546791e-20 NA NA NA hsa-miR-139-5p PSME4 -3.25846663863766 2.62018989415003e-112 0.337884927693191 2.61253739828762e-05 PITA;miRanda -0.12196693421685 9.06785624732544e-14 NA NA NA hsa-miR-335-5p PSORS1C1 -2.61355235628987 2.6462884165886e-51 0.512467651466977 0.0104812352936098 miRNAWalker2_validate -0.104817517748399 0.00488353317078243 NA NA NA hsa-miR-139-5p PSPH -3.25846663863766 2.62018989415003e-112 0.969900071110203 8.47541355183454e-25 MirTarget;miRanda -0.195935591258793 7.43632415913778e-24 NA NA NA hsa-miR-486-5p PSRC1 -3.87258704301474 1.22658629378451e-80 1.97416833805815 1.01965081849198e-62 miRanda -0.196639640723196 1.83051053773328e-25 NA NA NA hsa-miR-21-5p PTAR1 2.32007501846389 3.08394781855554e-137 -0.905827340400495 1.03583920772408e-26 miRNAWalker2_validate;mirMAP -0.314881803765506 2.43582463683508e-33 NA NA NA hsa-miR-429 PTAR1 2.84108892259147 3.88520896426515e-64 -0.905827340400495 1.03583920772408e-26 MirTarget;miRNATAP -0.108361064967426 3.68375056134237e-11 NA NA NA hsa-miR-96-5p PTAR1 3.24596558166606 1.92296159041707e-98 -0.905827340400495 1.03583920772408e-26 TargetScan -0.122407668821423 7.15697637465799e-13 NA NA NA hsa-miR-10b-5p PTCD1 -2.10996264627796 7.36811595736367e-72 0.715672650818626 1.57159030704783e-28 mirMAP -0.212359154063954 1.23801724444336e-35 NA NA NA hsa-miR-141-3p PTCH1 2.99777540204168 1.26370498493024e-78 -1.99144733451091 8.8131310666777e-41 TargetScan;miRNATAP -0.259642531273444 3.49181018900683e-18 NA NA NA hsa-miR-183-5p PTCH1 2.95681814393872 1.09965777344285e-92 -1.99144733451091 8.8131310666777e-41 miRNATAP -0.320708912265667 1.96370717679254e-23 NA NA NA hsa-miR-200a-3p PTCH1 2.55218480823434 2.96135446816238e-51 -1.99144733451091 8.8131310666777e-41 miRNATAP -0.234599971595617 1.47282799732142e-15 NA NA NA hsa-miR-200b-3p PTCH1 2.11744072703209 1.66710572104191e-43 -1.99144733451091 8.8131310666777e-41 TargetScan -0.239031658469218 3.16803727762646e-13 NA NA NA hsa-miR-21-5p PTCH1 2.32007501846389 3.08394781855554e-137 -1.99144733451091 8.8131310666777e-41 mirMAP -0.521741532586734 2.36520849124019e-28 NA NA NA hsa-miR-375 PTCH1 2.09893673049766 1.68351780396203e-16 -1.99144733451091 8.8131310666777e-41 miRanda -0.182234588300658 2.0897729520062e-19 NA NA NA hsa-miR-429 PTCH1 2.84108892259147 3.88520896426515e-64 -1.99144733451091 8.8131310666777e-41 PITA;miRanda;miRNATAP -0.222706109376063 2.65826510113626e-14 NA NA NA hsa-miR-141-3p PTCHD1 2.99777540204168 1.26370498493024e-78 -3.92879851720895 4.87722585188742e-36 mirMAP -0.417489936928319 3.61072935593697e-11 NA NA NA hsa-miR-200a-3p PTCHD1 2.55218480823434 2.96135446816238e-51 -3.92879851720895 4.87722585188742e-36 mirMAP -0.385118778435802 5.16061869468264e-10 NA NA NA hsa-miR-21-5p PTCHD1 2.32007501846389 3.08394781855554e-137 -3.92879851720895 4.87722585188742e-36 mirMAP -0.766536202392272 2.72475491242887e-14 NA NA NA hsa-miR-429 PTCHD1 2.84108892259147 3.88520896426515e-64 -3.92879851720895 4.87722585188742e-36 PITA;miRanda -0.380752519439908 6.20236010162159e-10 NA NA NA hsa-miR-96-5p PTCHD1 3.24596558166606 1.92296159041707e-98 -3.92879851720895 4.87722585188742e-36 TargetScan -0.612150898834286 3.57979833426e-22 NA NA NA hsa-miR-141-3p PTCHD3 2.99777540204168 1.26370498493024e-78 -3.42394320451458 1.59157910515074e-31 TargetScan -0.480132158758225 1.61981125202704e-16 NA NA NA hsa-miR-200b-3p PTCHD3 2.11744072703209 1.66710572104191e-43 -3.42394320451458 1.59157910515074e-31 TargetScan -0.399761803900086 4.39001630281016e-10 NA NA NA hsa-miR-429 PTCHD3 2.84108892259147 3.88520896426515e-64 -3.42394320451458 1.59157910515074e-31 miRanda -0.398658408551825 2.78172219451663e-12 NA NA NA hsa-miR-141-3p PTEN 2.99777540204168 1.26370498493024e-78 -0.737945156702629 1.26474514880987e-22 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.12717832397844 6.47904977288109e-18 27644195;24742567 Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis drug resistance;tumorigenesis esophageal cancer;endometrial cancer hsa-miR-200a-3p PTEN 2.55218480823434 2.96135446816238e-51 -0.737945156702629 1.26474514880987e-22 miRNATAP -0.109411985169924 5.36101217094024e-14 22637745;24742567;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ;tumorigenesis; pancreatic cancer;endometrial cancer;pancreatic cancer hsa-miR-200b-3p PTEN 2.11744072703209 1.66710572104191e-43 -0.737945156702629 1.26474514880987e-22 TargetScan;mirMAP -0.130827329200595 5.08867014435072e-16 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-200c-3p PTEN 2.07038651806183 6.84613386286599e-51 -0.737945156702629 1.26474514880987e-22 mirMAP;miRNATAP -0.143190372668334 7.03511808200308e-16 24682933;22637745 In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment metastasis;poor survival; colon cancer;pancreatic cancer hsa-miR-21-5p PTEN 2.32007501846389 3.08394781855554e-137 -0.737945156702629 1.26474514880987e-22 miRNAWalker2_validate;miRTarBase;mirMAP -0.241962926381789 5.21884080644212e-25 26387181;21471222;26905520;25027758;21820606;24930006;22547075;26666820;23951172;25647415;22678116;22832383;19212625;22267008;26384051;22322462;27644439;21468550;20113523;21806946;24154840;27611950;24780321;23036707;23684551;26559642;26731559;26847601;27350731;24331411;25909227;24293118;26289851;24324076;23201752;17681183;25963606;27188433;22958183;22956424;19730150;21842656;21104017;23894315;23548551;26236156;24460329;20092645;25973032;25563770;24659669;26230405;25543482;20048743;27725205;23466500;22922228;25058005;20223231;27220494;24763002;24221338;22120473;21408027;23174819;22978663;25799148;26741162;23226804;26787105;26864640;26311740;25603978;26975392 In addition treated with 5-AZA resulted in significant increases of miR-21 expression in both MCF-7 and MDA-MB-231 cells P < 0.01 with the protein level of PTEN increased in MCF-7 cell which was further involved in the downregulation of AKT;Here we demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2+ BT474 SKBR3 and MDA-MB-453 breast cancer cells that are induced to acquire trastuzumab resistance by long-term exposure to the antibody whereas protein expression of the PTEN gene a miR-21 target was reduced; Rescuing PTEN expression with a p3XFLAG-PTEN-mut construct with deleted miR-21 targeting sequence at its 3' UTR restored the growth inhibition of trastuzumab in the resistant cells by inducing PTEN activation and AKT inhibition; In vivo administering miR-21 antisense oligonucleotides restored trastuzumab sensitivity in the resistant breast cancer xenografts by inducing PTEN expression whereas injection of miR-21 mimics conferred trastuzumab resistant in the sensitive breast tumors via PTEN silence;The effect of ZA on miR-21 expression was quantified by qRT-PCR and the amount of PTEN protein and its targets were analyzed by Western blot;In the same patients we also compared miR-21 expression with the expression of its presumed target PTEN; miR-21 expression levels were found to significantly correlate with tumour size r = 0.403 p = 0.009; Spearman's rank whereas no relation was found between miR-21 and PTEN expression levels Kruskal-Wallis test;MicroRNA 21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN; TaqMan RT-PCR or Western blot assay was performed to detect the expression of mature miR-21 and tumor suppressor gene PTEN protein; We showed that upregulation of miR-21 in MCF-7/ADR cells was concurrent with downregulation of PTEN protein; Overexpression of PTEN could mimic the same effects of miR-21 inhibitor in MCF-7/ADR cells and PTEN-siRNA could increase the resistance of MCF-7 cells to ADR; MiR-21 inhibitor could increase PTEN protein expression and the luciferase activity of a PTEN 3' untranslated region-based reporter construct in MCF-7/ADR cells; Dysregulation of miR-21 plays critical roles in the ADR resistance of breast cancer at least in part via targeting PTEN;In present study we determined the miR-21 levels in TNBC specimens and TNBC cell levels in vitro and then identified the role of miR-21 on tumor cell proliferation apoptosis and then identified PTEN as the possible target of the microRNA;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;PTEN a direct target gene of miR-21 was significantly downregulated in gemcitabine-resistant breast cancer cells and restoration of PTEN expression blocked miR-21-induced EMT and gemcitabine resistance;The results showed that knockdown of miR-21 by antagomir-21 decreased cell proliferation and induced apoptosis via targeting PTEN both in 4T1 cells and HUVECs;MiR-21 upregulation contributes to PTEN downregulation which is beneficial for the activation of PI3K/AKT signaling;Furthermore miR-21-induced upregulation of CSF-1 mRNA and its transcription were prevented by expression of PTEN mRNA lacking 3'-untranslated region UTR and miR-21 recognition sequence; Our results reveal a novel mechanism for the therapeutic function of fish oil diet that blocks miR-21 thereby increasing PTEN levels to prevent expression of CSF-1 in breast cancer;After miR-21 was transfected in MCF-7 cells PTEN protein level was measured by Western blot; Matrine up-regulated PTEN by downregulating miR-21 which in turn dephosphorylated Akt resulting in accumulation of Bad p21/WAF1/CIP1 and p27/KIP1;To further determine the potential involvement of miR-21 in breast cancer we have evaluated the expression level of miR-21 by stem-loop real-time RT-PCR based on SYBR-Green I in human invasive ductal carcinoma of the breast and we have correlated the results with clinicopathologic features and PTEN protein expression; The expression levels of miR-21 were correlated with PTEN and commonly used clinicopathologic features of breast cancer; Expression of miR-21 was negatively correlated with expression of PTEN P=0.013; These findings suggest that PTEN is possibly one of the targets of miR-21 in breast cancer and high expression of mir-21 indicates a more aggressive phenotype;microRNA 21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN; Thus in this study we focused on the expression and significance of miR-21 in gastric cancer tissues and the role of miR-21 in the biological behaviour and the expression of PTEN in gastric cancer cells; Western blotting and the Luciferase Reporter Assay were used to evaluate the change of PTEN expression after lowered expression of miR-21 in gastric cancer cell lines; The western blot results and Luciferase Reporter Assay demonstrated that PTEN expression was remarkably increased after miR-21 inhibition P<0.05 microRNA-21 expression was upregulated in gastric carcinoma tissues and was significantly associated with the degree of differentiation of tumour tissues local invasion and lymph node metastasis;Furthermore we identified that miR-21 overexpression could promote Hela and U2OS cells proliferation by targeting phosphatase-tensin homolog PTEN the result of which can be rescued by miR-21 inhibitor;Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon;Bmi-1 also regulates p53 and PTEN via miR-21;The expression of miR-21 and its target PTEN was determined by real-time qRT-PCR and western blotting respectively in tumor tissues as well as adjacent non-tumor mucosa; miR-21 was significantly up-regulated in tumor tissues while PTEN was expressed in lower levels compared to non-tumor tissues; A negative correlation between expression of miR-21 and PTEN was established in vivo;MicroRNA 21 inhibitor sensitizes human glioblastoma cells U251 PTEN mutant and LN229 PTEN wild type to taxol; Human glioblastoma U251 PTEN-mutant and LN229 PTEN wild-type cells were treated with taxol and the miR-21 inhibitor in a poly amidoamine PAMAM dendrimer alone or in combination; Interestingly the above data suggested that in both the PTEN mutant and the wild-type GBM cells miR-21 blockage increased the chemosensitivity to taxol; Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;NTR1 activation stimulates expression of miR-21 and miR-155 in colonocytes via Akt and NF-κB to down-regulate PTEN and SOCS1 and promote growth of tumors in mice;Correlations between the expression levels of miR-21 PTEN and p-AKT were analyzed by real-time PCR and Western blot test in HER2-positive GC cell lines; Overexpression of miR-21 down-regulated PTEN expression increased AKT phosphorylation and did not affect HER2 expression; Inversely suppression of miR-21 increased PTEN expression and down-regulated AKT phosphorylation but still did not affect HER2 expression;MicroRNA 21 promotes TGF β1 induced epithelial mesenchymal transition in gastric cancer through up regulating PTEN expression; In GC tissues the expressions of miR-21 Akt and p-Akt were up-regulated while PTEN expression was down-regulated; These results suggest that miR-21 could promote TGF-β1-induced EMT in GC cells through up-regulating PTEN expression;Expressions of PTEN were significantly down-regulated in CRC tissues and negatively correlated with expressions of Notch-1 r2=0.5207 p<0.01 and miR-21 r2=0.6996 p<0.01; These data indicate that the crosstalk between Notch-1 and miR-21 is involved in CRC development through degradation of PTEN;Over-expression of miR-21 suppressed its target PTEN and disrupted acinar morphogenesis;MicroRNA 21 suppresses PTEN and hSulf 1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways;There was overexpression of the miR-21 target genes PTEN by 67% and caspase-3 by 15% upon cotreatment;We previously reported that microRNA-21 miR-21 was strongly expressed in melanoma relative to naevi and now sought to further assess the significance of this by assessing its relationship with its putative target PTEN; Clinical melanoma samples were analysed by immunohistochemical analysis for PTEN stem-loop qRT-PCR for miR-21 and PCR for BRAF/NRAS mutation status; miR-21 expression was inversely associated with nuclear PTEN expression but not with cytoplasmic PTEN expression; These data suggest miR-21 may exert an oncogenic effect in melanoma by favouring redistribution of PTEN to the nucleus;Triptolide reduces proliferation and enhances apoptosis of human non small cell lung cancer cells through PTEN by targeting miR 21; To the best of our knowledge the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human NSCLC cells through PTEN by targeting miR-21;Quantitative real-time PCR qRT-PCR and Western blot were used to detect the expression levels of miR-21 and PTEN in HCT116 HT29 Colo32 and SW480 CRC cell lines; Also the expression levels of PTEN mRNA and its downstream proteins AKT and PI3K in HCT116 cells after downregulating miR-21 were investigated; In comparing the levels of PTEN protein and downstream AKT and PI3K in HCT116 cells after downregulation of miR-21 expression the levels of AKT and PI3K protein expression significantly decreased P < 0.05; PTEN is one of the direct target genes of miR-21;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;MiR-21 level was inversely correlated with the levels of FOXO1 and PTEN in DLBCL cell lines; MiR-21 also down-regulated PTEN expression and consequently activated the PI3K/AKT/mTOR pathway which further decreased FOXO1 expression;MiR 21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non small cell lung cancer A549 cells; Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin; Moreover the protein level of PTEN a putative target of microRNA-21 was significantly elevated in curcumin-treated A549 cells as determined by Western blot analysis; Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA significantly P < 0.05 reversed the growth suppression and apoptosis induction by curcumin compared to corresponding controls; Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells;PTEN gene expression was performed as a known target of miR-21;We also found that Rawq01 up-regulated the expression of PTEN through mir-21 inhibition and therefore inhibited the PI3K-AKT pathway;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;MicroRNA 21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer; PTEN was shown to be a direct target of miR-21 and to contribute to miR-21 effects on cell invasion; Modulation of miR-21 altered focal adhesion kinase phosphorylation and expression of matrix metalloproteases 2 and 9 both downstream mediators of PTEN involved in cell migration and invasion; Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth migration and invasion;Overexpression of miR 21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN; The aim of this study was to examine the expression of miR-21 and PTEN in cervical cancer specimens using quantitative PCR; miR-21 was upregulated in the cervical cancer specimens negatively correlating with the PTEN mRNA level; Transfection of the miR-21 mimics was markedly promoted whereas the miR-21 inhibitor suppressed the proliferation migration and invasion of cervical cancer cells with a significant inhibition of PTEN expression; The present study showed the upregulation of miR-21 in invasive cervical cancers and confirmed the promotion of miR-21 with regard to the proliferation migration and invasion in cervical cancer cells via inhibiting the PTEN expression;The expressions of miR-21 PTEN PI3K and AKT were detected in 89 esophageal cancer samples and 58 adjacent normal tissues respectively; MiR-21 PI3K and AKT have higher expressions but PTEN has lower expression in esophageal cancer tissues compared with adjacent normal tissues; Further PTEN was a target gene of miR-21;The expression level of miR-21 and PTEN messenger RNA were measured by quantitative real-time reverse transcription polymerase chain reaction or reverse transcription polymerase chain reaction; miR-21 was overexpressed and PTEN was suppressed in established radioresistant TE-R60 cells compared with the parent cells 1.3-fold and 70.83%; The inhibition of miR-21 significantly increased the cells' radiosensitivity P < 0.05 and the PTEN protein expression 2.3-fold in TE-1 cells; Knockdown of PTEN in anti-miR-21 TE-1 cells could abrogate the miR-21 inhibition-induced radiosensitization P < 0.05; Inhibition of miR-21 increased radiosensitivity of esophageal cancer TE-1 cells and this effect was possibly through the activation of PTEN;MicroRNA 21 miR 21 expression promotes growth metastasis and chemo or radioresistance in non small cell lung cancer cells by targeting PTEN; Taken together these results provide evidence to show the promotion role of miR-21 in NSCLC development through modulation of the PTEN signaling pathway;Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Role of microRNA 21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma; To evaluate the role of miR-21 and PTEN cell proliferations were analyzed with miR-21 mimics or their inhibitor-transfected cells; In Eca109 when transfected with miR-21 mimics accumulation of miR-21 was obviously increased and expression of PTEN protein was decreased to be approximately 40% which resulted in the promotion of cell proliferation; However when transfected with miR-21 inhibitor expression of miR-21 was declined and PTEN protein was overexpressed to be approximately 79% which resulted in the suppression of cell proliferation; Furthermore there was a significantly inverse correlation between miR-21 expression and PTEN protein levels p < 0.05; The author concluded that MiR-21 was overexpressed in vitro and ESCC and promoted the cell proliferation might target PTEN at post-transcriptional level and regulated the cancer invasion in Kazakh's ESCC;Difluorinated curcumin CDF restores PTEN expression in colon cancer cells by down regulating miR 21; Indeed our current data demonstrate a marked downregulation of PTEN in SCID mice xenografts of miR-21 over-expressing colon cancer HCT116 cells; Colonospheres that are highly enriched in cancer stem/stem like cells reveal increased miR-21 expression and decreased PTEN; Difluorinated curcumin CDF a novel analog of the dietary ingredient curcumin which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;Mechanistic evidence showed that down-regulation of miR-21 increased the expression of its target molecule PTEN in HCT116 cells;Finally invasion and metastasis assays were performed and alteration in mir-21 PTEN AKT and pAKT level was evaluated in these cells; Enhanced invasion and metastasis increased miR-21 expression decreased PTEN elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells;In the present study we investigated the role of miR-21 and its potential as a therapeutic target in two prostate cancer cell lines characterized by different miR-21 expression levels and PTEN gene status;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;Expressions of microRNA-21 miR-21 PTEN MMP9 and p47 were detected by qPCR;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;microRNA 21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder Cancer; MicroRNA-21 regulates proliferation and migration of bladder cancer cells and cross talk with PTEN and p53 in bladder cancer;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status; To explore whether miR-21 can serve as a therapeutic target for glioblastoma we downregulated miR-21 with a specific antisense oligonucleotide and found that apoptosis was induced and cell-cycle progression was inhibited in vitro in U251 PTEN mutant and LN229 PTEN wild-type GBM cells; xenograft tumors from antisense-treated U251 cells were suppressed in vivo; Taken together our studies provide evidence that miR-21 may serve as a novel therapeutic target for malignant gliomas independent of PTEN status;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated; In conclusion our data suggest that mUA can suppress cell viability in DU145 cells through modulating miR-21 and its downstream series-wound targets including PTEN Akt and Wnt/β-catenin signaling;miR 21 confers cisplatin resistance in gastric cancer cells by regulating PTEN; In addition miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 PTEN and activation of Akt pathway;Finally we demonstrate that modulation of tumor suppressors PTEN and p53 in U87 cells does not affect the decrease in miR-21 levels associated with PDGF-B overexpression;This study aimed to investigate whether NSCLC miR-21 mediated resistance to TKIs also results from Pten targeting; Here we show miR-21 promotes cancer by negatively regulating Pten expression in human NSCLC tissues: high miR-21 expression levels were associated with shorter DFS in 47 NSCLC patients; high miR-21/low Pten expression levels indicated a poor TKI clinical response and shorter overall survival in another 46 NSCLC patients undergoing TKI treatment; In vitro assays showed that miR-21 was up-regulated concomitantly to down-regulation of Pten in pc-9/GR cells in comparison with pc-9 cells; Moreover over-expression of miR-21 significantly decreased gefitinib sensitivity by down-regulating Pten expression and activating Akt and ERK pathways in pc-9 cells while miR-21 knockdown dramatically restored gefitinib sensitivity of pc-9/GR cells by up-regulation of Pten expression and inactivation of AKT and ERK pathways in vivo and in vitro;MicroRNA 21 miR 21 represses tumor suppressor PTEN and promotes growth and invasion in non small cell lung cancer NSCLC; We identified the role of miR-21 in non-small cell lung cancer NSCLC and to clarify the regulation of PTEN by miR-21 and determine mechanisms of this regulation; Expression of miR-21 and PTEN in 20 paired NSCLC and adjacent non-tumor lung tissues was investigated by qRT-PCR and western blot respectively; Tumor tissues showed an inverse correlation between miR-21 and PTEN protein; miR-21 inhibitor transfection increased a luciferase-reporter activity containing the PTEN-3'-UTR construct and increased PTEN protein but not PTEN-mRNA levels in NSCLC cell lines; miR-21 post-transcriptionally down-regulates the expression of tumor suppressor PTEN and stimulates growth and invasion in NSCLC;MiR-21 overexpression decreases PTEN increases p-Akt and subsequently increases HIF-1α expression while miR-21 inhibition results in increased PTEN decreased p-Akt and then decreased HIF-1α;This study was aimed to investigate the expression of microRNA-21 and its correlation with PTEN in diffuse large B cell lymphoma DLBCL paraffin-embedded tissues and evaluate its potential relevance with clinical characteristics; In patients with DLBCL the expression level of miR-21 was negatively correlated with the level of PTEN protein; These findings suggest that PTEN is possibly one of the targets of miR-21 in DLBCL;Down regulation of PTEN expression modulated by dysregulated miR 21 contributes to the progression of esophageal cancer; We demonstrated that knockdown of miR-21 significantly increased expression of PTEN protein; Our findings suggest that miR-21 could be a potential oncomiR probably by regulation of PTEN and a novel prognostic factor for ESCC patients;The levels of mir-21 did not associate with the expression of PTEN an important tumour suppressor in CRC and one of many putative targets of miR-21 but interestingly was associated with stage of disease in the PTEN expressing tumours;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants;The PTEN protein levels in CRC tissues and cells had an inverse correlation with miR-21 expression; MiR-21 targets PTEN at the post-transcriptional level and regulates cell proliferation and invasion in CRC;These findings demonstrate a novel role of AR in the regulation of miR-21 and its target PTEN in growth factor-induced colon cancer cell growth;Whether miR-21 regulated PTEN expression was assessed by luciferase assay; The RNA and protein levels of PTEN were significantly decreased by exogenous miR-21 and the 3'-untranslated region of PTEN was shown to be a target of miR-21;In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets including PTEN and DDAH1 in A549 cells while increasing their sensitivity toward paclitaxel PTX;microRNA 21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer; We performed a qRT-PCR assay with miR-21 and PTEN in 16 paired EEC tumor tissues and adjacent non-tumor endometrium; To validate the putative binding site of miR-21 in the 3' untranslated region 3'-UTR of PTEN messenger RNA mRNA a dual-luciferase reporter assay was carried out; The upregulation of miR-21 led to a significant decrease in the PTEN protein expression level P=0.007; The downregulation of miR-21 led to a significant increase in PTEN protein P=0.002; In conclusion we demonstrated that the expression of PTEN protein but not mRNA was negatively directly regulated by miR-21 in the KLE cell line; The overexpression of miR-21 modulated EEC cell proliferation through the downregulation of PTEN;The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR 21 and promoter methylation; In this study we investigated the effect of miR-21 and promoter methylation on the PTEN expression status in CRC tissues and analyzed association of the PTEN expression status with clinicopathological features in patients with CRC; PTEN mRNA level was negatively correlated with miR-21 level r = -0.595 P < 0.001; PTEN expression was also correlated directly with the PTEN mRNA level r = 0.583 P < 0.001 and conversely with miR-21 level r = -0.632 P < 0.001; This study suggests a high frequency of miR-21 overexpression and aberrant promoter methylation in down-regulation of PTEN expression in colorectal carcinoma;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Exposure of HCC cells to sorafenib led to an increase in miR-21 expression a decrease in PTEN expression and sequential Akt activation;MicroRNA 21 controls hTERT via PTEN in human colorectal cancer cell proliferation; The aim of this study was to determine a role of microRNA-21 miRNA-21 in colorectal cancer CRC and to elucidate miRNA-21 regulation of hTERT by phosphatase and tensin homologue PTEN;Relevance of miR 21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells; We identified the tumor suppressor gene PTEN as a target of miR-21 and determined the mechanism of its regulation throughout reporter construct plasmids; Using this model we analyzed the expression of miR-21 and PTEN as well as functional effects such as autophagy and apoptosis induction; In SiHa cells there was an inverse correlation between miR-21 expression and PTEN mRNA level as well as PTEN protein expression in cervical cancer cells; We conclude that miR-21 post-transcriptionally down-regulates the expression of PTEN to promote cell proliferation and cervical cancer cell survival ;drug resistance;;;drug resistance;;;drug resistance;;;;;;metastasis;differentiation;;tumorigenesis;;;;;;;;;progression;;;;;drug resistance;;;;;;cell migration;;;;metastasis;drug resistance;;;;;;;metastasis;;;;;;;progression;malignant trasformation;;drug resistance;poor survival;;drug resistance;poor survival;;;;progression;staging;;;;;;;;drug resistance;;;poor survival breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;gastric cancer;cervical and endocervical cancer;colon cancer;gastric cancer;bladder cancer;glioblastoma;colon cancer;gastric cancer;gastric cancer;colorectal cancer;lung cancer;liver cancer;glioblastoma;melanoma;lung squamous cell cancer;colorectal cancer;lung squamous cell cancer;B cell lymphoma;lung squamous cell cancer;thyroid cancer;esophageal cancer;glioblastoma;liver cancer;cervical and endocervical cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;pancreatic cancer;lung cancer;esophageal cancer;colon cancer;B cell lymphoma;colon cancer;pancreatic cancer;prostate cancer;liver cancer;lung cancer;gastric cancer;bladder cancer;B cell lymphoma;glioblastoma;prostate cancer;gastric cancer;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;cervical and endocervical cancer;B cell lymphoma;esophageal cancer;colorectal cancer;pancreatic cancer;colorectal cancer;colon cancer;lung squamous cell cancer;lung cancer;endometrial cancer;colorectal cancer;pancreatic cancer;liver cancer;colorectal cancer;cervical and endocervical cancer hsa-miR-429 PTEN 2.84108892259147 3.88520896426515e-64 -0.737945156702629 1.26474514880987e-22 PITA;miRanda;mirMAP;miRNATAP -0.13365636792818 1.00274002812788e-20 NA NA NA hsa-miR-200b-3p PTGDR 2.11744072703209 1.66710572104191e-43 -1.45601735106844 5.15780746632607e-19 TargetScan -0.306411093360221 1.12408198064579e-18 NA NA NA hsa-miR-429 PTGER2 2.84108892259147 3.88520896426515e-64 -1.03079951827812 1.77190651955296e-10 miRanda;miRNATAP -0.232176972077398 2.65502796951239e-14 NA NA NA hsa-miR-182-5p PTGER3 2.36408084103818 2.60011457600281e-72 -2.08536199219359 1.19288336263977e-20 miRNATAP -0.238585050285685 1.19335786642096e-05 NA NA NA hsa-miR-429 PTGER3 2.84108892259147 3.88520896426515e-64 -2.08536199219359 1.19288336263977e-20 miRanda;miRNATAP -0.389202604162027 5.27939463893609e-20 NA NA NA hsa-miR-96-5p PTGER3 3.24596558166606 1.92296159041707e-98 -2.08536199219359 1.19288336263977e-20 TargetScan;miRNATAP -0.401215058288863 1.58464085927239e-19 NA NA NA hsa-miR-429 PTGER4 2.84108892259147 3.88520896426515e-64 -1.65323006136447 1.66826240713502e-43 miRanda -0.314903414353618 6.22160906724177e-44 NA NA NA hsa-miR-139-5p PTGES3 -3.25846663863766 2.62018989415003e-112 0.34107114856719 1.06087815882311e-10 miRanda -0.112953370935667 2.23621579638511e-26 NA NA NA hsa-miR-182-5p PTGFR 2.36408084103818 2.60011457600281e-72 -3.14817947469536 1.79211321073315e-43 MirTarget -0.741655252596842 2.79348715720429e-42 NA NA NA hsa-miR-21-5p PTGFR 2.32007501846389 3.08394781855554e-137 -3.14817947469536 1.79211321073315e-43 miRNAWalker2_validate -0.744982504356861 1.57528731294261e-24 NA NA NA hsa-miR-429 PTGFR 2.84108892259147 3.88520896426515e-64 -3.14817947469536 1.79211321073315e-43 PITA -0.522066994313502 9.68894837542233e-33 NA NA NA hsa-miR-429 PTGIS 2.84108892259147 3.88520896426515e-64 -2.15074778286955 8.58222226999305e-35 miRNATAP -0.373211401263677 5.70586516647736e-29 NA NA NA hsa-miR-429 PTGS2 2.84108892259147 3.88520896426515e-64 -3.06633598017193 1.49322904633926e-36 miRanda;miRNATAP -0.404133193488026 1.1658704706728e-17 NA NA NA hsa-miR-375 PTH2R 2.09893673049766 1.68351780396203e-16 -2.178747497059 1.48830289461757e-20 miRanda -0.136435813383783 1.56716759666158e-05 NA NA NA hsa-miR-182-5p PTHLH 2.36408084103818 2.60011457600281e-72 -1.44742776852114 2.01207752809059e-10 MirTarget -0.151853692872458 0.00562453787143307 NA NA NA hsa-miR-200b-3p PTHLH 2.11744072703209 1.66710572104191e-43 -1.44742776852114 2.01207752809059e-10 MirTarget;TargetScan -0.160626397844438 0.000990186901529906 NA NA NA hsa-miR-200c-3p PTHLH 2.07038651806183 6.84613386286599e-51 -1.44742776852114 2.01207752809059e-10 MirTarget -0.21000719036726 8.82486626068071e-05 NA NA NA hsa-miR-429 PTHLH 2.84108892259147 3.88520896426515e-64 -1.44742776852114 2.01207752809059e-10 MirTarget;PITA;miRanda -0.192550728734971 9.31406934091461e-06 NA NA NA hsa-miR-139-5p PTK2 -3.25846663863766 2.62018989415003e-112 0.34551403513174 7.59893035573032e-07 miRanda -0.109205234931847 1.69268288863156e-14 NA NA NA hsa-miR-378a-5p PTOV1 -2.43173551693523 1.44932837789175e-68 0.814351650572315 1.8953874060114e-21 miRNAWalker2_validate -0.205406310182631 1.52533538780058e-26 NA NA NA hsa-miR-200b-3p PTPN11 2.11744072703209 1.66710572104191e-43 -0.73371833861962 7.24333657010257e-22 TargetScan -0.131913631045747 6.43155343439281e-16 NA NA NA hsa-miR-200c-3p PTPN11 2.07038651806183 6.84613386286599e-51 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109200606157251 1.61966841065561e-09 NA NA NA hsa-miR-429 PTPN11 2.84108892259147 3.88520896426515e-64 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109747504497674 5.95008429105521e-14 NA NA NA hsa-miR-200b-3p PTPN13 2.11744072703209 1.66710572104191e-43 -0.809960140594897 7.91282502499025e-08 TargetScan -0.173793950896567 5.80741713962217e-08 NA NA NA hsa-miR-200c-3p PTPN13 2.07038651806183 6.84613386286599e-51 -0.809960140594897 7.91282502499025e-08 miRNAWalker2_validate;miRTarBase -0.18590883585444 1.33149075961008e-07 NA NA NA hsa-miR-429 PTPN13 2.84108892259147 3.88520896426515e-64 -0.809960140594897 7.91282502499025e-08 PITA;miRanda -0.1835276509375 1.21260876574694e-10 NA NA NA hsa-miR-200b-3p PTPN14 2.11744072703209 1.66710572104191e-43 -1.86383552012172 8.31373613084314e-42 MirTarget;TargetScan -0.214736349959927 1.54418322506977e-12 NA NA NA hsa-miR-200c-3p PTPN14 2.07038651806183 6.84613386286599e-51 -1.86383552012172 8.31373613084314e-42 MirTarget -0.274273570115621 1.50306938607158e-16 NA NA NA hsa-miR-21-5p PTPN14 2.32007501846389 3.08394781855554e-137 -1.86383552012172 8.31373613084314e-42 miRNAWalker2_validate;MirTarget -0.397227308894507 2.68785339242311e-19 NA NA NA hsa-miR-375 PTPN14 2.09893673049766 1.68351780396203e-16 -1.86383552012172 8.31373613084314e-42 mirMAP -0.195856467535379 4.61168552765944e-26 NA NA NA hsa-miR-429 PTPN14 2.84108892259147 3.88520896426515e-64 -1.86383552012172 8.31373613084314e-42 MirTarget;miRNATAP -0.206640791848542 2.20535246731312e-14 NA NA NA hsa-miR-200b-3p PTPN21 2.11744072703209 1.66710572104191e-43 -1.65383053269161 3.3398027285675e-48 TargetScan -0.258284554743192 2.14008560718297e-25 NA NA NA hsa-miR-200c-3p PTPN21 2.07038651806183 6.84613386286599e-51 -1.65383053269161 3.3398027285675e-48 miRNATAP -0.365419761984016 9.07989896626038e-43 NA NA NA hsa-miR-429 PTPN21 2.84108892259147 3.88520896426515e-64 -1.65383053269161 3.3398027285675e-48 PITA;miRanda;miRNATAP -0.243357686018922 2.72925098707945e-28 NA NA NA hsa-miR-182-5p PTPN4 2.36408084103818 2.60011457600281e-72 -0.772006027943853 1.97809004778744e-27 mirMAP;miRNATAP -0.106109494846757 9.65543345287222e-10 NA NA NA hsa-miR-429 PTPN4 2.84108892259147 3.88520896426515e-64 -0.772006027943853 1.97809004778744e-27 miRNATAP -0.103199055048454 5.3098033107787e-14 NA NA NA hsa-miR-96-5p PTPN4 3.24596558166606 1.92296159041707e-98 -0.772006027943853 1.97809004778744e-27 TargetScan;miRNATAP -0.100759150403759 2.1752915582854e-12 NA NA NA hsa-miR-335-5p PTPN7 -2.61355235628987 2.6462884165886e-51 1.11717276563442 3.54528943195632e-13 miRNAWalker2_validate -0.13210856069372 4.66746395404188e-06 NA NA NA hsa-miR-21-5p PTPRB 2.32007501846389 3.08394781855554e-137 -2.08700500825601 4.8814959213602e-55 mirMAP -0.573556491022332 1.12847861657235e-41 NA NA NA hsa-miR-429 PTPRB 2.84108892259147 3.88520896426515e-64 -2.08700500825601 4.8814959213602e-55 miRNATAP -0.38495784368469 9.66205037999545e-52 NA NA NA hsa-miR-139-5p PTPRD -3.25846663863766 2.62018989415003e-112 0.150114854210014 0.427806011089459 miRanda;miRNATAP -0.136491912614922 0.00044998991688663 NA NA NA hsa-miR-141-3p PTPRD 2.99777540204168 1.26370498493024e-78 0.150114854210014 0.427806011089459 miRNAWalker2_validate;TargetScan;miRNATAP -0.252890035581267 3.43971076968601e-12 NA NA NA hsa-miR-200a-3p PTPRD 2.55218480823434 2.96135446816238e-51 0.150114854210014 0.427806011089459 miRNAWalker2_validate;miRNATAP -0.264438339347084 1.0759495244519e-13 NA NA NA hsa-miR-200b-3p PTPRD 2.11744072703209 1.66710572104191e-43 0.150114854210014 0.427806011089459 miRNAWalker2_validate -0.30522980195377 1.14494479230952e-14 NA NA NA hsa-miR-200c-3p PTPRD 2.07038651806183 6.84613386286599e-51 0.150114854210014 0.427806011089459 miRNAWalker2_validate -0.341096545199508 4.09077043221735e-15 NA NA NA hsa-miR-429 PTPRD 2.84108892259147 3.88520896426515e-64 0.150114854210014 0.427806011089459 miRNAWalker2_validate;miRanda;miRNATAP -0.207246248212851 5.6259521731375e-09 NA NA NA hsa-miR-429 PTPRE 2.84108892259147 3.88520896426515e-64 -0.634850899663758 2.4631062343997e-13 miRanda;miRNATAP -0.146522807298196 2.53319353478275e-19 NA NA NA hsa-miR-141-3p PTPRG 2.99777540204168 1.26370498493024e-78 -1.29644517088256 8.3671572754937e-21 MirTarget;TargetScan;miRNATAP -0.333940878967987 1.24675139386592e-36 NA NA NA hsa-miR-182-5p PTPRG 2.36408084103818 2.60011457600281e-72 -1.29644517088256 8.3671572754937e-21 MirTarget;miRNATAP -0.235017920991251 2.07870644182989e-12 NA NA NA hsa-miR-200a-3p PTPRG 2.55218480823434 2.96135446816238e-51 -1.29644517088256 8.3671572754937e-21 MirTarget;miRNATAP -0.28345921779417 3.35874915203545e-27 NA NA NA hsa-miR-429 PTPRG 2.84108892259147 3.88520896426515e-64 -1.29644517088256 8.3671572754937e-21 miRNATAP -0.281612929089642 3.23196190299493e-27 NA NA NA hsa-miR-96-5p PTPRG 3.24596558166606 1.92296159041707e-98 -1.29644517088256 8.3671572754937e-21 TargetScan;miRNATAP -0.28208764311792 4.64192721334945e-25 NA NA NA hsa-miR-429 PTPRM 2.84108892259147 3.88520896426515e-64 -1.57471720317321 4.81055293304317e-48 miRNATAP -0.339320387738888 4.62335092783007e-64 NA NA NA hsa-miR-139-5p PTPRO -3.25846663863766 2.62018989415003e-112 0.794392382175529 2.25775792277064e-10 miRanda -0.172995496214237 1.93080353339383e-11 NA NA NA hsa-miR-429 PTPRQ 2.84108892259147 3.88520896426515e-64 -4.45062053043103 6.69255101058467e-44 miRanda -0.572819353201037 6.60831906987143e-20 NA NA NA hsa-miR-96-5p PTPRQ 3.24596558166606 1.92296159041707e-98 -4.45062053043103 6.69255101058467e-44 TargetScan -0.642083014960055 7.0473140385517e-23 NA NA NA hsa-miR-21-5p PTPRT 2.32007501846389 3.08394781855554e-137 -0.922018035462999 0.0136915437550837 mirMAP -0.375910517469041 0.0012689006814031 NA NA NA hsa-miR-200b-3p PTPRZ1 2.11744072703209 1.66710572104191e-43 -4.20756137566181 6.32393300486789e-30 MirTarget -0.290948027136067 0.000350497055176143 NA NA NA hsa-miR-200c-3p PTPRZ1 2.07038651806183 6.84613386286599e-51 -4.20756137566181 6.32393300486789e-30 MirTarget;miRNATAP -0.508617189702044 1.08811052740162e-08 NA NA NA hsa-miR-429 PTPRZ1 2.84108892259147 3.88520896426515e-64 -4.20756137566181 6.32393300486789e-30 MirTarget;PITA;miRanda;miRNATAP -0.403848887303825 2.31046491326899e-08 NA NA NA hsa-miR-139-5p PTRH1 -3.25846663863766 2.62018989415003e-112 1.27655141978746 5.52090331250641e-27 miRanda -0.158277454955263 2.44435394046525e-10 NA NA NA hsa-miR-21-5p PTX3 2.32007501846389 3.08394781855554e-137 -2.78450381423429 2.94811759736246e-26 miRNAWalker2_validate -0.495263579161642 3.54088043602359e-09 NA NA NA hsa-miR-21-5p PURA 2.32007501846389 3.08394781855554e-137 -0.438047613118832 4.75770651979866e-13 miRNAWalker2_validate -0.155663617479665 1.10539908337268e-16 NA NA NA hsa-miR-21-5p PURB 2.32007501846389 3.08394781855554e-137 -0.170814756591027 0.00173600287338175 miRNAWalker2_validate;mirMAP;miRNATAP -0.120679210280138 6.04808886411543e-13 NA NA NA hsa-miR-141-3p PXK 2.99777540204168 1.26370498493024e-78 -0.593312260816982 1.83895419398506e-09 MirTarget;TargetScan -0.152506649644455 1.16365951879434e-15 NA NA NA hsa-miR-200a-3p PXK 2.55218480823434 2.96135446816238e-51 -0.593312260816982 1.83895419398506e-09 MirTarget -0.133003624826933 1.34262930229881e-12 NA NA NA hsa-miR-200b-3p PYGO1 2.11744072703209 1.66710572104191e-43 -1.89478551615963 1.39585960146891e-22 mirMAP -0.389994931400337 3.17627670880994e-21 NA NA NA hsa-miR-200c-3p PYGO1 2.07038651806183 6.84613386286599e-51 -1.89478551615963 1.39585960146891e-22 mirMAP -0.377790343694091 1.22974201087685e-16 NA NA NA hsa-miR-21-3p PYGO1 2.17476065946878 5.15299442583591e-75 -1.89478551615963 1.39585960146891e-22 mirMAP -0.211982831151191 5.03070950480372e-05 NA NA NA hsa-miR-21-5p PYGO1 2.32007501846389 3.08394781855554e-137 -1.89478551615963 1.39585960146891e-22 mirMAP -0.488388055538722 1.24796373463689e-15 NA NA NA hsa-miR-429 PYGO1 2.84108892259147 3.88520896426515e-64 -1.89478551615963 1.39585960146891e-22 mirMAP -0.356609280981808 3.11793717951246e-22 NA NA NA hsa-miR-141-3p QKI 2.99777540204168 1.26370498493024e-78 -1.32659632374889 1.06640742607879e-48 TargetScan -0.263244011547577 6.74334706147368e-51 NA NA NA hsa-miR-182-5p QKI 2.36408084103818 2.60011457600281e-72 -1.32659632374889 1.06640742607879e-48 mirMAP -0.30834767509175 4.55118000124757e-46 NA NA NA hsa-miR-200a-5p QKI 2.58844508672328 1.79650654234569e-56 -1.32659632374889 1.06640742607879e-48 mirMAP -0.223877484331126 1.38482576738191e-35 NA NA NA hsa-miR-200b-3p QKI 2.11744072703209 1.66710572104191e-43 -1.32659632374889 1.06640742607879e-48 TargetScan -0.27656462658597 7.84044727568241e-47 NA NA NA hsa-miR-375 QKI 2.09893673049766 1.68351780396203e-16 -1.32659632374889 1.06640742607879e-48 miRanda -0.164118705604812 2.46064182729981e-42 NA NA NA hsa-miR-429 QKI 2.84108892259147 3.88520896426515e-64 -1.32659632374889 1.06640742607879e-48 PITA;miRanda;miRNATAP -0.227741195694544 2.40897352390339e-39 NA NA NA hsa-miR-96-5p QKI 3.24596558166606 1.92296159041707e-98 -1.32659632374889 1.06640742607879e-48 TargetScan -0.261737839841462 2.04474900094745e-48 NA NA NA hsa-miR-335-5p QPRT -2.61355235628987 2.6462884165886e-51 1.29442298882395 1.05994381952326e-12 miRNAWalker2_validate -0.205368822633628 1.46313830526038e-09 NA NA NA hsa-miR-378a-5p QSOX1 -2.43173551693523 1.44932837789175e-68 0.60255748274154 3.62670004110163e-08 mirMAP -0.214841922746055 1.55730998754006e-18 NA NA NA hsa-miR-452-5p QSOX1 -2.48486455572568 1.24430987974325e-33 0.60255748274154 3.62670004110163e-08 mirMAP -0.118738757983793 9.2685056037116e-12 NA NA NA hsa-miR-141-3p RAB11FIP2 2.99777540204168 1.26370498493024e-78 -0.940510639961515 7.61132098193432e-42 MirTarget -0.153668996619729 3.81056557287882e-29 NA NA NA hsa-miR-183-5p RAB11FIP2 2.95681814393872 1.09965777344285e-92 -0.940510639961515 7.61132098193432e-42 miRNATAP -0.143186849168711 1.49717072755599e-21 NA NA NA hsa-miR-200a-3p RAB11FIP2 2.55218480823434 2.96135446816238e-51 -0.940510639961515 7.61132098193432e-42 MirTarget -0.145235347794193 5.04463877491733e-27 NA NA NA hsa-miR-200b-3p RAB11FIP2 2.11744072703209 1.66710572104191e-43 -0.940510639961515 7.61132098193432e-42 MirTarget;TargetScan -0.154694324874895 8.80637401715132e-25 NA NA NA hsa-miR-200c-3p RAB11FIP2 2.07038651806183 6.84613386286599e-51 -0.940510639961515 7.61132098193432e-42 MirTarget;miRNATAP -0.168205426171744 3.11114089610281e-24 NA NA NA hsa-miR-21-5p RAB11FIP2 2.32007501846389 3.08394781855554e-137 -0.940510639961515 7.61132098193432e-42 miRNAWalker2_validate -0.29824575737227 1.91429477956097e-43 NA NA NA hsa-miR-429 RAB11FIP2 2.84108892259147 3.88520896426515e-64 -0.940510639961515 7.61132098193432e-42 MirTarget;PITA;miRanda;miRNATAP -0.158049156989614 1.47916047487932e-32 NA NA NA hsa-miR-378a-5p RAB11FIP3 -2.43173551693523 1.44932837789175e-68 0.852276970856492 7.56554829503693e-20 mirMAP -0.312446141901832 1.09706006739844e-53 NA NA NA hsa-miR-145-5p RAB11FIP4 -2.62703571936687 7.64402900188551e-88 1.53441164799704 3.50928776989217e-42 MirTarget -0.307953995505967 5.50103778404683e-31 NA NA NA hsa-miR-452-5p RAB11FIP4 -2.48486455572568 1.24430987974325e-33 1.53441164799704 3.50928776989217e-42 MirTarget -0.193153361643073 1.06729906017479e-25 NA NA NA hsa-miR-486-5p RAB11FIP4 -3.87258704301474 1.22658629378451e-80 1.53441164799704 3.50928776989217e-42 miRNATAP -0.185450103425863 3.24981931171589e-26 NA NA NA hsa-miR-378a-5p RAB15 -2.43173551693523 1.44932837789175e-68 0.680561480072377 2.91882823982896e-12 mirMAP -0.130262321675413 4.27710756532306e-09 NA NA NA hsa-miR-200b-3p RAB23 2.11744072703209 1.66710572104191e-43 0.076671251457137 0.39594420106942 TargetScan -0.103715807740545 4.84000345070298e-08 NA NA NA hsa-miR-335-5p RAB26 -2.61355235628987 2.6462884165886e-51 3.22441958560925 2.67179235601649e-52 miRNAWalker2_validate -0.382174188497487 1.40676500564699e-20 NA NA NA hsa-miR-511-5p RAB27B -2.27545475897362 3.84085514050558e-36 0.157909039164941 0.404607674683261 MirTarget -0.115495215394141 0.00079843163659357 NA NA NA hsa-miR-21-5p RAB30 2.32007501846389 3.08394781855554e-137 -0.478979836326187 0.00389471393081148 mirMAP -0.264676085801825 2.7904893470383e-07 NA NA NA hsa-miR-452-5p RAB30 -2.48486455572568 1.24430987974325e-33 -0.478979836326187 0.00389471393081148 mirMAP -0.225271947700095 5.16968131120998e-18 NA NA NA hsa-miR-141-5p RAB32 2.38411349683216 4.56310582620282e-58 -0.239478509277985 0.00293095179406377 MirTarget -0.135690580092698 1.5405653430021e-15 NA NA NA hsa-miR-452-5p RAB39B -2.48486455572568 1.24430987974325e-33 0.482072090722851 0.0185769063770752 mirMAP -0.132777173011367 4.83492311380014e-05 NA NA NA hsa-miR-144-5p RAB3B -2.75914786146772 1.55794225315972e-50 0.498804996172488 0.0458786066380825 mirMAP -0.145320696088875 0.000837787269867395 NA NA NA hsa-miR-452-5p RAB3B -2.48486455572568 1.24430987974325e-33 0.498804996172488 0.0458786066380825 mirMAP -0.10775387847213 0.00700124394183601 NA NA NA hsa-miR-141-3p RAB3C 2.99777540204168 1.26370498493024e-78 -2.54624635924093 4.17710497877998e-25 mirMAP -0.519206437285959 1.52328825828455e-27 NA NA NA hsa-miR-200a-3p RAB3C 2.55218480823434 2.96135446816238e-51 -2.54624635924093 4.17710497877998e-25 mirMAP -0.384698813583737 6.09458879874517e-16 NA NA NA hsa-miR-96-5p RAB3C 3.24596558166606 1.92296159041707e-98 -2.54624635924093 4.17710497877998e-25 TargetScan -0.465553528952214 1.91015996776808e-21 NA NA NA hsa-miR-182-5p RAB6B 2.36408084103818 2.60011457600281e-72 -1.3809693710295 1.41420129464503e-25 miRNATAP -0.346809195056789 2.33964554431215e-28 NA NA NA hsa-miR-429 RAB6B 2.84108892259147 3.88520896426515e-64 -1.3809693710295 1.41420129464503e-25 miRNATAP -0.181533687059894 1.05355606318044e-12 NA NA NA hsa-miR-96-5p RAB6B 3.24596558166606 1.92296159041707e-98 -1.3809693710295 1.41420129464503e-25 TargetScan;miRNATAP -0.23140409567755 1.8572063312358e-18 NA NA NA hsa-miR-141-3p RAB8B 2.99777540204168 1.26370498493024e-78 -0.735083061711054 5.77801459708655e-22 MirTarget -0.175711365588715 2.66665848868704e-33 NA NA NA hsa-miR-183-5p RAB8B 2.95681814393872 1.09965777344285e-92 -0.735083061711054 5.77801459708655e-22 MirTarget;miRNATAP -0.151601514509813 4.71391921507385e-21 NA NA NA hsa-miR-200a-3p RAB8B 2.55218480823434 2.96135446816238e-51 -0.735083061711054 5.77801459708655e-22 MirTarget -0.150397339738036 3.09646179132943e-25 NA NA NA hsa-miR-200b-3p RAB8B 2.11744072703209 1.66710572104191e-43 -0.735083061711054 5.77801459708655e-22 TargetScan;mirMAP -0.170309156827483 3.69181942005047e-26 NA NA NA hsa-miR-200c-3p RAB8B 2.07038651806183 6.84613386286599e-51 -0.735083061711054 5.77801459708655e-22 mirMAP;miRNATAP -0.197937237799856 2.97827516188044e-29 NA NA NA hsa-miR-429 RAB8B 2.84108892259147 3.88520896426515e-64 -0.735083061711054 5.77801459708655e-22 PITA;miRanda;mirMAP;miRNATAP -0.151084710673675 8.11775816253229e-26 NA NA NA hsa-miR-96-5p RAB8B 3.24596558166606 1.92296159041707e-98 -0.735083061711054 5.77801459708655e-22 MirTarget;TargetScan;miRNATAP -0.172992673593452 3.86433841165557e-31 NA NA NA hsa-miR-183-5p RAB9B 2.95681814393872 1.09965777344285e-92 -1.36287381394326 1.05244960313168e-18 miRNATAP -0.183197895788069 2.90977633953807e-08 NA NA NA hsa-miR-429 RAB9B 2.84108892259147 3.88520896426515e-64 -1.36287381394326 1.05244960313168e-18 miRNATAP -0.190156882409653 1.31340028033578e-10 NA NA NA hsa-miR-96-5p RAB9B 3.24596558166606 1.92296159041707e-98 -1.36287381394326 1.05244960313168e-18 TargetScan -0.225100815667489 2.60871079831271e-13 NA NA NA hsa-miR-452-5p RABEP1 -2.48486455572568 1.24430987974325e-33 -0.210962848317383 0.0452838127956761 mirMAP -0.213332233678406 2.03174534441853e-40 NA NA NA hsa-miR-10b-5p RABEP2 -2.10996264627796 7.36811595736367e-72 1.43860023754439 3.29687569393832e-36 mirMAP -0.266954865385291 1.49642573675613e-17 NA NA NA hsa-miR-21-5p RABGAP1 2.32007501846389 3.08394781855554e-137 -0.353944039502493 2.60184057257328e-11 miRNAWalker2_validate -0.134129704547964 2.97349628454221e-16 NA NA NA hsa-miR-101-3p RAC1 -0.126035286271986 0.145997832808138 0.176628662773421 0.000153658997491136 miRNAWalker2_validate;MirTarget -0.139972978942608 1.93650351223228e-14 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.0550374855074773 0.65382485898551 0.739175691283857 1.48014827234175e-09 miRNAWalker2_validate -0.163439972898065 2.05534635731132e-06 NA NA NA hsa-miR-491-5p RAC2 -1.04307210952796 1.14586501470398e-15 0.739175691283857 1.48014827234175e-09 miRanda -0.170510866222564 9.84222871672058e-08 NA NA NA hsa-miR-125a-5p RAC3 -0.635694700253268 3.6703235721638e-11 1.34875128530309 1.88353993751843e-24 PITA -0.214154670070607 8.31103753734932e-06 NA NA NA hsa-miR-139-5p RACGAP1 -3.25846663863766 2.62018989415003e-112 1.66861356419623 7.72216670898327e-51 miRanda -0.351550744719996 2.07359261434761e-53 NA NA NA hsa-miR-139-5p RAD21 -3.25846663863766 2.62018989415003e-112 0.640163471263341 1.00173451347388e-10 miRanda -0.181519146531913 2.19972816533815e-19 NA NA NA hsa-miR-452-5p RAD50 -2.48486455572568 1.24430987974325e-33 -0.135555077373277 0.0888619388234284 MirTarget -0.113016272564666 1.04401408908458e-19 NA NA NA hsa-miR-486-5p RAD51AP1 -3.87258704301474 1.22658629378451e-80 2.02748456333948 8.85223367729415e-50 miRanda -0.218471737723355 2.90284713225266e-24 NA NA NA hsa-miR-99a-5p RAD51C -2.25079447371102 1.14086813185885e-54 0.342584537310918 0.000107956717117322 miRNAWalker2_validate -0.14787936980669 2.20708387090126e-14 NA NA NA hsa-miR-141-3p RAD54L2 2.99777540204168 1.26370498493024e-78 -0.957945852257672 1.5527860874268e-11 TargetScan -0.135848834638527 1.05295111710358e-06 NA NA NA hsa-miR-141-3p RAG1 2.99777540204168 1.26370498493024e-78 -1.39090074941032 2.39566741675824e-25 TargetScan -0.221347757180805 3.95274659637967e-17 NA NA NA hsa-miR-200b-3p RAG1 2.11744072703209 1.66710572104191e-43 -1.39090074941032 2.39566741675824e-25 MirTarget -0.168266344426961 6.6970077945692e-09 NA NA NA hsa-miR-200c-3p RAG1 2.07038651806183 6.84613386286599e-51 -1.39090074941032 2.39566741675824e-25 MirTarget -0.220512181672642 3.92886762076485e-12 NA NA NA hsa-miR-429 RAG1 2.84108892259147 3.88520896426515e-64 -1.39090074941032 2.39566741675824e-25 MirTarget;miRanda;miRNATAP -0.188893800865913 2.25810338412698e-13 NA NA NA hsa-miR-452-5p RAI1 -2.48486455572568 1.24430987974325e-33 0.558918533569503 3.32293842326678e-13 MirTarget;miRNATAP -0.100425840321699 2.03747700357122e-16 NA NA NA hsa-miR-139-5p RAI14 -3.25846663863766 2.62018989415003e-112 0.695118045350182 3.61907682886332e-14 miRanda -0.161619308622037 8.68338567827269e-18 NA NA NA hsa-miR-429 RAI2 2.84108892259147 3.88520896426515e-64 -1.47256517322369 2.60789671978509e-16 miRNATAP -0.286652808265756 3.97603929875799e-17 NA NA NA hsa-miR-429 RALGAPA2 2.84108892259147 3.88520896426515e-64 -1.2413029823528 2.85199338717754e-12 miRNATAP -0.217070862688823 1.32090430067325e-10 NA NA NA hsa-miR-452-5p RALGAPB -2.48486455572568 1.24430987974325e-33 0.114339916324857 0.110018355395065 mirMAP -0.105247687804124 3.60765029941074e-21 NA NA NA hsa-miR-224-5p RALGPS1 -2.22249420723892 1.07787949391113e-18 0.320371955401898 0.000743623076739109 MirTarget -0.153608281754376 6.53878909680175e-37 NA NA NA hsa-miR-144-5p RALGPS2 -2.75914786146772 1.55794225315972e-50 0.889426971470516 5.63881052160942e-09 mirMAP -0.125212256511643 2.79437117087911e-06 NA NA NA hsa-miR-378a-5p RALGPS2 -2.43173551693523 1.44932837789175e-68 0.889426971470516 5.63881052160942e-09 MirTarget -0.486974863244595 6.91893003258321e-50 NA NA NA hsa-miR-486-5p RALGPS2 -3.87258704301474 1.22658629378451e-80 0.889426971470516 5.63881052160942e-09 miRanda -0.141043112830669 1.20732440806109e-09 NA NA NA hsa-miR-200b-3p RAPGEF1 2.11744072703209 1.66710572104191e-43 -0.577309067105408 2.14055895898889e-26 TargetScan -0.115991922575951 9.13877211713485e-24 NA NA NA hsa-miR-21-5p RAPGEF1 2.32007501846389 3.08394781855554e-137 -0.577309067105408 2.14055895898889e-26 mirMAP -0.137769492193029 9.12627757448983e-16 NA NA NA hsa-miR-429 RAPGEF1 2.84108892259147 3.88520896426515e-64 -0.577309067105408 2.14055895898889e-26 miRanda;miRNATAP -0.107099534738026 2.12340378849762e-25 NA NA NA hsa-miR-141-3p RAPGEF2 2.99777540204168 1.26370498493024e-78 -1.07954431946973 1.09869317643974e-45 MirTarget;TargetScan;miRNATAP -0.190427522928983 4.04692361635089e-37 NA NA NA hsa-miR-200a-3p RAPGEF2 2.55218480823434 2.96135446816238e-51 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.167119036962075 1.78754985294303e-29 NA NA NA hsa-miR-200b-3p RAPGEF2 2.11744072703209 1.66710572104191e-43 -1.07954431946973 1.09869317643974e-45 MirTarget;TargetScan -0.179237551056118 2.21593713134509e-27 NA NA NA hsa-miR-200c-3p RAPGEF2 2.07038651806183 6.84613386286599e-51 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.202553658903887 6.1626718024825e-29 NA NA NA hsa-miR-429 RAPGEF2 2.84108892259147 3.88520896426515e-64 -1.07954431946973 1.09869317643974e-45 MirTarget;PITA;miRanda;miRNATAP -0.17437988631643 1.29609092060223e-32 NA NA NA hsa-miR-429 RAPGEF4 2.84108892259147 3.88520896426515e-64 -0.614113009957709 1.45825091828705e-06 miRanda;miRNATAP -0.161412066708766 1.82744800936032e-11 NA NA NA hsa-miR-21-5p RAPGEF6 2.32007501846389 3.08394781855554e-137 -0.634373510285263 0.000139010469658275 miRNAWalker2_validate -0.264839527208078 3.17267996573965e-07 NA NA NA hsa-miR-96-5p RAPGEF6 3.24596558166606 1.92296159041707e-98 -0.634373510285263 0.000139010469658275 miRNATAP -0.110888414758641 0.00077893930022188 NA NA NA hsa-miR-21-5p RAPH1 2.32007501846389 3.08394781855554e-137 -0.29515042585972 0.000790740625597494 miRNAWalker2_validate;mirMAP -0.118213062647856 1.56328984637089e-05 NA NA NA hsa-miR-141-3p RARB 2.99777540204168 1.26370498493024e-78 -1.28928084445976 3.54851642399018e-22 TargetScan;miRNATAP -0.152445904660738 7.47123153584678e-09 NA NA NA hsa-miR-200a-3p RARB 2.55218480823434 2.96135446816238e-51 -1.28928084445976 3.54851642399018e-22 miRNATAP -0.105743334819733 4.77795115323628e-05 NA NA NA hsa-miR-21-5p RASA1 2.32007501846389 3.08394781855554e-137 -0.294730586920749 0.000766494242183886 miRNATAP -0.149767999849588 3.5184635352839e-08 25663768;27101583 RKO cells were transfected with vectors overexpressing or down-regulating either miR-21 or RASA1; Furthermore a luciferase reporter assay was used to determine whether RASA1 is a gene target of miR-21; RASA1 protein levels were significantly decreased in RKO cells compared with the other 5 colon cancer cell lines and RASA1 was confirmed as a target gene of miR-21; Interestingly RASA1 mRNA and protein levels in pre-miR-21-LV up-regulation of miR-21 cells were lower than those in anti-miR-21-LV down-regulation of miR-21 cells P < 0.05; RASA1 is a target gene of miR-21 which promotes malignant behaviors of RKO cells through regulation of RASA1 expression;Circulating MicroRNA 21 Is Involved in Lymph Node Metastasis in Cervical Cancer by Targeting RASA1; Then cervical cancer cell lines HeLa HPV-18 DNA E6/E7RNA and HT-3 HPV DNA E6/E7RNA were used to confirm the interaction between miR-21 and RASA1; MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1 malignant trasformation;metastasis;cell migration colon cancer;cervical and endocervical cancer hsa-miR-141-3p RASA2 2.99777540204168 1.26370498493024e-78 -0.987338236523419 4.85695047036301e-10 TargetScan -0.114558440879572 0.000231326184807738 NA NA NA hsa-miR-200b-3p RASA2 2.11744072703209 1.66710572104191e-43 -0.987338236523419 4.85695047036301e-10 TargetScan -0.116042713824606 0.000635084861671019 NA NA NA hsa-miR-141-3p RASA4 2.99777540204168 1.26370498493024e-78 -0.759819487285073 1.42668565311618e-13 mirMAP -0.161911829090065 4.4653227116395e-16 NA NA NA hsa-miR-200a-3p RASA4 2.55218480823434 2.96135446816238e-51 -0.759819487285073 1.42668565311618e-13 mirMAP -0.113592876991353 8.69071762139026e-09 NA NA NA hsa-miR-200c-3p RASAL2 2.07038651806183 6.84613386286599e-51 -0.566349890853123 1.84617719047055e-11 mirMAP -0.113399606662439 9.2548700645001e-09 NA NA NA hsa-miR-375 RASD1 2.09893673049766 1.68351780396203e-16 -1.95553230360219 3.4725544484432e-22 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.130277507987086 1.71447338617167e-06 20978187 A combination of expression profiling from tumor samples and miRNA target prediction identified RASD1 as a potential miR-375 target; Mechanistic investigations revealed that miR-375 regulates RASD1 by targeting the 3' untranslated region in RASD1 mRNA breast cancer hsa-miR-429 RASD1 2.84108892259147 3.88520896426515e-64 -1.95553230360219 3.4725544484432e-22 miRNATAP -0.349330607802026 9.83314694876973e-20 NA NA NA hsa-miR-224-5p RASEF -2.22249420723892 1.07787949391113e-18 0.754159608276906 0.00222565595269572 MirTarget -0.260730969089573 7.17620023934144e-16 NA NA NA hsa-miR-200b-3p RASGEF1B 2.11744072703209 1.66710572104191e-43 -1.24434781637468 2.49466982652341e-23 mirMAP -0.173110614504983 1.45918717867934e-10 NA NA NA hsa-miR-429 RASGEF1B 2.84108892259147 3.88520896426515e-64 -1.24434781637468 2.49466982652341e-23 miRanda;miRNATAP -0.152846983576336 2.36026101816459e-10 NA NA NA hsa-miR-139-5p RASGRF1 -3.25846663863766 2.62018989415003e-112 0.743117588404357 0.000669318514784322 MirTarget;miRanda -0.135490498006884 0.00264937757767138 NA NA NA hsa-miR-182-5p RASGRF2 2.36408084103818 2.60011457600281e-72 -1.50231288432749 1.31976412389238e-25 mirMAP -0.332608173999958 4.42625198160884e-22 NA NA NA hsa-miR-429 RASGRF2 2.84108892259147 3.88520896426515e-64 -1.50231288432749 1.31976412389238e-25 miRanda -0.374968653023569 2.6237327482128e-45 NA NA NA hsa-miR-486-5p RASGRP1 -3.87258704301474 1.22658629378451e-80 0.973407990771331 1.43757924621451e-07 miRanda -0.106236099814952 0.000171212137177818 NA NA NA hsa-miR-139-5p RASL11B -3.25846663863766 2.62018989415003e-112 1.96084521955866 2.82598534905973e-38 miRanda -0.255438856050174 2.16114737719661e-15 NA NA NA hsa-miR-141-3p RASSF2 2.99777540204168 1.26370498493024e-78 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.135873264046898 1.85145668024501e-11 NA NA NA hsa-miR-141-5p RASSF2 2.38411349683216 4.56310582620282e-58 -0.0757663600101672 0.471968773241686 mirMAP -0.111796020990197 6.60930551110177e-07 NA NA NA hsa-miR-200a-3p RASSF2 2.55218480823434 2.96135446816238e-51 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.122092807456322 8.31045841692893e-10 NA NA NA hsa-miR-200b-3p RASSF2 2.11744072703209 1.66710572104191e-43 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.132962009202936 1.87793486378845e-09 NA NA NA hsa-miR-200c-3p RASSF2 2.07038651806183 6.84613386286599e-51 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.15915180997094 5.64117330111008e-11 NA NA NA hsa-miR-429 RASSF2 2.84108892259147 3.88520896426515e-64 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate;miRNATAP -0.100751584617521 3.71813984922737e-07 NA NA NA hsa-miR-141-3p RASSF8 2.99777540204168 1.26370498493024e-78 -1.0150883507772 8.73226382591887e-14 TargetScan -0.192508382074018 3.83103579263277e-13 NA NA NA hsa-miR-200b-3p RASSF8 2.11744072703209 1.66710572104191e-43 -1.0150883507772 8.73226382591887e-14 TargetScan -0.184036405558272 2.3235209242109e-10 NA NA NA hsa-miR-200c-3p RASSF8 2.07038651806183 6.84613386286599e-51 -1.0150883507772 8.73226382591887e-14 miRNATAP -0.1890325037856 3.39391770795434e-09 NA NA NA hsa-miR-429 RASSF8 2.84108892259147 3.88520896426515e-64 -1.0150883507772 8.73226382591887e-14 miRanda;miRNATAP -0.182936610016986 1.48312153730781e-12 NA NA NA hsa-miR-96-5p RASSF8 3.24596558166606 1.92296159041707e-98 -1.0150883507772 8.73226382591887e-14 TargetScan;miRNATAP -0.212398303027158 2.80688398095932e-15 NA NA NA hsa-miR-429 RASSF9 2.84108892259147 3.88520896426515e-64 -2.69679495222506 3.93526865032685e-54 miRanda -0.391536509091729 1.32943110039994e-30 NA NA NA hsa-miR-196a-5p RAVER2 2.33423717464504 3.646557504928e-18 -0.804875245771148 5.08150420740063e-12 MirTarget -0.10432931325377 7.27934231131274e-13 NA NA NA hsa-miR-21-5p RB1 2.32007501846389 3.08394781855554e-137 -0.4298757717294 2.2641632984077e-06 miRNAWalker2_validate -0.178426586251413 2.52614483801181e-10 NA NA NA hsa-miR-139-5p RBBP7 -3.25846663863766 2.62018989415003e-112 0.724911495696889 5.97007522531942e-23 miRanda -0.174279508919095 2.32780329777545e-31 NA NA NA hsa-miR-511-5p RBKS -2.27545475897362 3.84085514050558e-36 0.731011877992525 1.21879695257732e-15 MirTarget -0.170743827299677 2.67463608605901e-25 NA NA NA hsa-miR-429 RBL2 2.84108892259147 3.88520896426515e-64 -0.777587758921412 2.2971094499013e-22 miRanda -0.114178875200587 9.05972696116893e-14 NA NA NA hsa-miR-10b-5p RBM17 -2.10996264627796 7.36811595736367e-72 0.142034545213337 0.0138226342542149 miRNAWalker2_validate -0.140289795778743 8.20071613971732e-21 NA NA NA hsa-miR-141-3p RBM20 2.99777540204168 1.26370498493024e-78 -1.04515069057265 1.01196665241559e-06 TargetScan -0.16345447334023 8.95290713776299e-05 NA NA NA hsa-miR-200b-3p RBM20 2.11744072703209 1.66710572104191e-43 -1.04515069057265 1.01196665241559e-06 MirTarget;TargetScan -0.150142477675714 0.000990554418747619 NA NA NA hsa-miR-200c-3p RBM20 2.07038651806183 6.84613386286599e-51 -1.04515069057265 1.01196665241559e-06 MirTarget -0.206131312038423 3.80541476757091e-05 NA NA NA hsa-miR-429 RBM20 2.84108892259147 3.88520896426515e-64 -1.04515069057265 1.01196665241559e-06 MirTarget;miRanda;miRNATAP -0.139550778522956 0.000606552379024185 NA NA NA hsa-miR-96-5p RBM20 3.24596558166606 1.92296159041707e-98 -1.04515069057265 1.01196665241559e-06 MirTarget;TargetScan;miRNATAP -0.176318323898911 3.22549076027586e-05 NA NA NA hsa-miR-141-3p RBM24 2.99777540204168 1.26370498493024e-78 -0.541667628704172 0.0692752095429657 TargetScan -0.137297704759525 0.0179697400157415 NA NA NA hsa-miR-139-5p RBM4 -3.25846663863766 2.62018989415003e-112 0.603924937485314 7.49605210703476e-30 miRanda -0.116522690459309 2.83447882341232e-26 NA NA NA hsa-miR-429 RBM43 2.84108892259147 3.88520896426515e-64 -0.710800046172253 3.94875576039551e-13 miRanda -0.134916448150649 3.66977382615654e-13 NA NA NA hsa-miR-141-3p RBM7 2.99777540204168 1.26370498493024e-78 -0.767424967277282 2.65334420291825e-24 MirTarget;TargetScan;miRNATAP -0.127521563165136 6.62209385971035e-18 NA NA NA hsa-miR-200a-3p RBM7 2.55218480823434 2.96135446816238e-51 -0.767424967277282 2.65334420291825e-24 MirTarget;miRNATAP -0.105220098862972 5.88235418010415e-13 NA NA NA hsa-miR-139-5p RBM8A -3.25846663863766 2.62018989415003e-112 0.624226706559294 1.62238873421736e-30 MirTarget;miRanda -0.133757909031142 3.03144864382884e-33 NA NA NA hsa-miR-141-3p RBMS1 2.99777540204168 1.26370498493024e-78 -1.10714556910667 3.80866209473109e-33 TargetScan;miRNATAP -0.21805819822546 5.13405207364821e-34 NA NA NA hsa-miR-141-5p RBMS1 2.38411349683216 4.56310582620282e-58 -1.10714556910667 3.80866209473109e-33 miRNATAP -0.215983676297123 3.33227863057729e-27 NA NA NA hsa-miR-183-5p RBMS1 2.95681814393872 1.09965777344285e-92 -1.10714556910667 3.80866209473109e-33 miRNATAP -0.190397610414456 5.4948291108745e-22 NA NA NA hsa-miR-200a-3p RBMS1 2.55218480823434 2.96135446816238e-51 -1.10714556910667 3.80866209473109e-33 miRNATAP -0.202929363327035 1.65635665551302e-30 NA NA NA hsa-miR-429 RBMS1 2.84108892259147 3.88520896426515e-64 -1.10714556910667 3.80866209473109e-33 miRNATAP -0.186675271548279 4.02268910412264e-26 NA NA NA hsa-miR-21-3p RBMS3 2.17476065946878 5.15299442583591e-75 -2.7715850255715 3.12754586243535e-63 MirTarget -0.428417566882113 1.27575249630753e-20 NA NA NA hsa-miR-200b-3p RBPJ 2.11744072703209 1.66710572104191e-43 -0.571459795835992 3.29001860179327e-24 mirMAP -0.107010469526237 5.01921033029508e-19 NA NA NA hsa-miR-200c-3p RBPJ 2.07038651806183 6.84613386286599e-51 -0.571459795835992 3.29001860179327e-24 mirMAP -0.111669221035834 3.26109227120596e-17 NA NA NA hsa-miR-21-5p RBPJ 2.32007501846389 3.08394781855554e-137 -0.571459795835992 3.29001860179327e-24 MirTarget;miRNATAP -0.18411640822153 6.25474791035248e-26 NA NA NA hsa-miR-182-5p RBPMS 2.36408084103818 2.60011457600281e-72 -1.08707167780304 1.78713086074911e-24 mirMAP -0.110105193468787 2.35997292967443e-05 NA NA NA hsa-miR-429 RBPMS 2.84108892259147 3.88520896426515e-64 -1.08707167780304 1.78713086074911e-24 miRanda -0.141282911569271 5.81196094506663e-12 NA NA NA hsa-miR-139-5p RBX1 -3.25846663863766 2.62018989415003e-112 0.647024426818053 3.59244462846658e-20 miRanda -0.138659130309957 7.99349725093936e-22 NA NA NA hsa-miR-200b-3p RC3H2 2.11744072703209 1.66710572104191e-43 -0.61834807347816 5.44570104079728e-08 mirMAP -0.129617960026112 8.08181996594934e-08 NA NA NA hsa-miR-200c-3p RC3H2 2.07038651806183 6.84613386286599e-51 -0.61834807347816 5.44570104079728e-08 mirMAP -0.101924113480864 0.000133105502626976 NA NA NA hsa-miR-429 RC3H2 2.84108892259147 3.88520896426515e-64 -0.61834807347816 5.44570104079728e-08 mirMAP -0.112175756346755 2.02404735559084e-07 NA NA NA hsa-miR-429 RCAN2 2.84108892259147 3.88520896426515e-64 -1.1736080925394 8.63928499401297e-31 miRNATAP -0.267822463132988 1.66395834671213e-45 NA NA NA hsa-miR-335-5p RCC2 -2.61355235628987 2.6462884165886e-51 1.09460053647386 4.62157678801416e-59 mirMAP -0.12403964903227 5.045090471297e-21 NA NA NA hsa-miR-99a-5p RCN2 -2.25079447371102 1.14086813185885e-54 0.359940474542713 2.91248106459011e-08 miRNAWalker2_validate -0.105029317870414 1.81972231944879e-13 NA NA NA hsa-miR-429 RCSD1 2.84108892259147 3.88520896426515e-64 -0.999313314075075 1.44421881626424e-17 miRNATAP -0.14453385255959 1.13071828384415e-10 NA NA NA hsa-miR-182-5p RDX 2.36408084103818 2.60011457600281e-72 -0.777241607854884 9.59924790525334e-16 MirTarget;miRNATAP -0.203341151293633 8.9609381999616e-19 NA NA NA hsa-miR-429 RDX 2.84108892259147 3.88520896426515e-64 -0.777241607854884 9.59924790525334e-16 PITA;miRanda -0.127512416579758 4.58879276869427e-12 NA NA NA hsa-miR-96-5p RDX 3.24596558166606 1.92296159041707e-98 -0.777241607854884 9.59924790525334e-16 TargetScan;miRNATAP -0.15663140331956 2.68797579336513e-16 NA NA NA hsa-miR-182-5p RECK 2.36408084103818 2.60011457600281e-72 -1.97765597525965 6.86857718929118e-55 miRNAWalker2_validate;miRNATAP -0.419040603016858 2.46535939427529e-42 27648365;23333633;23226455 In our previous results we demonstrated that miR-182 was over-expressed in breast cancer cell lines and clinical tumor tissues and its up-regulation increased tumorigenicity and invasiveness by repressing a tumor suppressor RECK;Up regulation of miR 182 by β catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK; The correlation between miR-182 and RECK was analyzed by Western blotting real-time RT-PCR and 3'-untranslated region reporter assay; Ectopic expression of miR-182 inhibited restoration of RECK protein by β-catenin inhibitor indicating miR-182 is important for β-catenin-induced down-regulation of RECK; An inverse association between miR-182 and RECK was demonstrated in breast tumor tissues; We provide evidence that miR-182 is up-regulated by β-catenin signaling pathway in breast cancer and its up-regulation increases tumorigenicity and invasiveness by repressing RECK; In addition we identify a new miR-182 target RECK which is important for miR-182-induced tumorigenesis;We also identified Smad4 and RECK as potential target genes of miR-182-5p using several algorithms; In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer ;tumorigenesis; breast cancer;breast cancer;bladder cancer hsa-miR-200b-3p RECK 2.11744072703209 1.66710572104191e-43 -1.97765597525965 6.86857718929118e-55 TargetScan -0.404451670676086 1.75438865191091e-50 NA NA NA hsa-miR-200c-3p RECK 2.07038651806183 6.84613386286599e-51 -1.97765597525965 6.86857718929118e-55 miRNATAP -0.482693977896726 1.13593688800954e-60 27574450;24647918 MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression cell migration; bladder cancer;lung cancer hsa-miR-21-5p RECK 2.32007501846389 3.08394781855554e-137 -1.97765597525965 6.86857718929118e-55 miRNAWalker2_validate;miRTarBase;miRNATAP -0.34438163056236 1.21607205369305e-16 19730150;20480266;22642976;18794849;25720799 Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression ;;staging;progression;progression;metastasis;progression pancreatic cancer;sarcoma;prostate cancer;gastric cancer;liver cancer hsa-miR-429 RECK 2.84108892259147 3.88520896426515e-64 -1.97765597525965 6.86857718929118e-55 PITA;miRanda;miRNATAP -0.376886287234823 1.65371973632574e-55 NA NA NA hsa-miR-96-5p RECK 3.24596558166606 1.92296159041707e-98 -1.97765597525965 6.86857718929118e-55 miRNATAP -0.420674564797926 1.12587332760724e-64 24366472;25465153;24469470 miR 96 promotes tumor proliferation and invasion by targeting RECK in breast cancer; Luciferase assays revealed that miR-96 directly bound to the 3'-untranslated region 3'-UTR of RECK qRT-PCR and western blot analysis confirmed that miR-96 regulated the expression of RECK both at the mRNA and protein levels;MiR 96 promotes proliferation and chemo or radioresistance by down regulating RECK in esophageal cancer; MiR-96 up-regulation was demonstrated in 145 EC samples and RECK down-regulation was validated in EC cell lines; RECK was identified as a target of miR-96 and RECK overexpressing could abrogate the growth of EC cells induced by miR-96; Taken together miR-96 serves as an oncogene role in EC cells through downregulating RECK;MiR 96 downregulates RECK to promote growth and motility of non small cell lung cancer cells; Reversion-inducing-cysteine-rich protein with kazal motifs RECK was identified as a target of miR-96 in NSCLC cells; In addition the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues; Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK ;drug resistance;motility breast cancer;esophageal cancer;lung squamous cell cancer hsa-miR-10b-5p RECQL5 -2.10996264627796 7.36811595736367e-72 0.522135641373015 1.32978229750359e-13 mirMAP -0.164514998320668 1.21418053192943e-18 NA NA NA hsa-miR-145-5p REEP1 -2.62703571936687 7.64402900188551e-88 0.546339756833729 0.0100889448892189 MirTarget -0.13001848885332 0.00849903489836659 NA NA NA hsa-miR-21-3p REEP1 2.17476065946878 5.15299442583591e-75 0.546339756833729 0.0100889448892189 MirTarget -0.209513900330708 0.000176847464488414 NA NA NA hsa-miR-511-5p REEP1 -2.27545475897362 3.84085514050558e-36 0.546339756833729 0.0100889448892189 MirTarget -0.299949884720987 3.46573249264286e-15 NA NA NA hsa-miR-200b-3p RELN 2.11744072703209 1.66710572104191e-43 -4.67087443281158 1.50848083381937e-55 MirTarget;TargetScan -0.657437580196194 1.99168662140682e-23 NA NA NA hsa-miR-200c-3p RELN 2.07038651806183 6.84613386286599e-51 -4.67087443281158 1.50848083381937e-55 MirTarget -0.830139052765864 6.0952837560973e-31 NA NA NA hsa-miR-429 RELN 2.84108892259147 3.88520896426515e-64 -4.67087443281158 1.50848083381937e-55 MirTarget;PITA;miRanda;miRNATAP -0.68086775368573 1.39890314174555e-31 NA NA NA hsa-miR-486-5p RELT -3.87258704301474 1.22658629378451e-80 1.70045791894704 7.42909511768129e-58 MirTarget;miRanda;miRNATAP -0.113176060519958 4.09107757523557e-11 NA NA NA hsa-miR-21-5p REST 2.32007501846389 3.08394781855554e-137 -0.529102545454462 0.00122391255708562 miRNAWalker2_validate;miRTarBase;mirMAP -0.234347286034385 4.181202706174e-06 NA NA NA hsa-miR-139-5p RET -3.25846663863766 2.62018989415003e-112 2.02749578906976 3.79233910696282e-13 miRanda -0.199832291035681 0.000604193603938145 NA NA NA hsa-miR-21-5p REV1 2.32007501846389 3.08394781855554e-137 -0.528969934645906 2.80157213580184e-33 miRNAWalker2_validate -0.169125772204719 2.51649067413995e-35 NA NA NA hsa-miR-183-5p REV3L 2.95681814393872 1.09965777344285e-92 -1.3253111779694 1.09960253991236e-38 miRNAWalker2_validate -0.163760220665286 1.68660707662328e-13 NA NA NA hsa-miR-21-5p REV3L 2.32007501846389 3.08394781855554e-137 -1.3253111779694 1.09960253991236e-38 miRNAWalker2_validate -0.395951006339526 2.50387473559502e-35 NA NA NA hsa-miR-429 REV3L 2.84108892259147 3.88520896426515e-64 -1.3253111779694 1.09960253991236e-38 miRanda -0.163233556575513 2.28003543721231e-16 NA NA NA hsa-miR-486-5p RFC2 -3.87258704301474 1.22658629378451e-80 1.04542977800845 8.3138937850249e-47 miRanda -0.103733232936342 1.37351489674298e-19 NA NA NA hsa-miR-139-5p RFC3 -3.25846663863766 2.62018989415003e-112 0.602782307825782 1.3786137574457e-12 miRanda -0.163755343479572 3.23132722056619e-21 NA NA NA hsa-miR-141-3p RFTN1 2.99777540204168 1.26370498493024e-78 -0.774029173591961 3.1218096841595e-14 MirTarget -0.269587408122593 1.48591241297219e-45 NA NA NA hsa-miR-182-5p RFTN1 2.36408084103818 2.60011457600281e-72 -0.774029173591961 3.1218096841595e-14 miRNATAP -0.260469241571122 1.0680225621901e-27 NA NA NA hsa-miR-200a-3p RFTN1 2.55218480823434 2.96135446816238e-51 -0.774029173591961 3.1218096841595e-14 MirTarget -0.225218984477146 1.97817456374995e-32 NA NA NA hsa-miR-429 RFTN1 2.84108892259147 3.88520896426515e-64 -0.774029173591961 3.1218096841595e-14 miRanda -0.214909222508738 7.11468494767079e-30 NA NA NA hsa-miR-96-5p RFTN1 3.24596558166606 1.92296159041707e-98 -0.774029173591961 3.1218096841595e-14 TargetScan;miRNATAP -0.217495436533256 4.69077558217259e-28 NA NA NA hsa-miR-200a-5p RFTN2 2.58844508672328 1.79650654234569e-56 -1.49900660141076 1.2863678959407e-37 MirTarget -0.308710596914169 5.15794419069813e-42 NA NA NA hsa-miR-200b-3p RFTN2 2.11744072703209 1.66710572104191e-43 -1.49900660141076 1.2863678959407e-37 MirTarget -0.365173933563426 1.38592923875734e-50 NA NA NA hsa-miR-200c-3p RFTN2 2.07038651806183 6.84613386286599e-51 -1.49900660141076 1.2863678959407e-37 MirTarget -0.450382599077655 1.38997568689061e-65 NA NA NA hsa-miR-429 RFTN2 2.84108892259147 3.88520896426515e-64 -1.49900660141076 1.2863678959407e-37 MirTarget;miRanda -0.325587761337787 2.05894098352302e-50 NA NA NA hsa-miR-139-5p RFWD3 -3.25846663863766 2.62018989415003e-112 0.395223169829141 3.66438847248276e-07 miRanda -0.134536445528289 1.53498044788975e-17 NA NA NA hsa-miR-141-3p RGAG1 2.99777540204168 1.26370498493024e-78 -0.770611426630889 1.84724689177991e-05 TargetScan -0.219823292822217 2.70459415665334e-10 NA NA NA hsa-miR-182-5p RGL1 2.36408084103818 2.60011457600281e-72 -1.67022879602185 1.06541172741944e-55 MirTarget -0.36525529228356 5.46943760201942e-46 NA NA NA hsa-miR-200b-3p RGL1 2.11744072703209 1.66710572104191e-43 -1.67022879602185 1.06541172741944e-55 MirTarget;TargetScan -0.323125969624857 2.26307711509585e-45 NA NA NA hsa-miR-200c-3p RGL1 2.07038651806183 6.84613386286599e-51 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.366117487037179 1.97365894301561e-48 NA NA NA hsa-miR-429 RGL1 2.84108892259147 3.88520896426515e-64 -1.67022879602185 1.06541172741944e-55 MirTarget;PITA;miRanda;miRNATAP -0.283616005237317 1.03067253781092e-43 NA NA NA hsa-miR-96-5p RGL1 3.24596558166606 1.92296159041707e-98 -1.67022879602185 1.06541172741944e-55 mirMAP -0.327210854911904 1.85368593228673e-54 NA NA NA hsa-miR-429 RGMA 2.84108892259147 3.88520896426515e-64 -2.14548336318726 3.38009486301913e-29 miRNATAP -0.203062781786981 5.28165477453132e-08 NA NA NA hsa-miR-375 RGN 2.09893673049766 1.68351780396203e-16 -3.24136216767839 1.75542402265639e-44 miRanda -0.25133943522917 2.71206119935792e-15 NA NA NA hsa-miR-139-5p RGS14 -3.25846663863766 2.62018989415003e-112 1.07825540659632 2.86340838605048e-22 miRanda -0.132077670904806 1.4672616986685e-08 NA NA NA hsa-miR-335-5p RGS16 -2.61355235628987 2.6462884165886e-51 0.811112846776397 8.18409403870695e-11 miRNAWalker2_validate -0.135517079755076 5.81255364310026e-09 NA NA NA hsa-miR-96-5p RGS2 3.24596558166606 1.92296159041707e-98 -2.22301490243853 1.94638141880336e-39 MirTarget;TargetScan;miRNATAP -0.447264351151191 8.28181927412815e-41 NA NA NA hsa-miR-486-5p RGS4 -3.87258704301474 1.22658629378451e-80 1.5186584496616 1.05908506042622e-18 PITA;miRanda -0.169974898920676 1.31452936466623e-10 NA NA NA hsa-miR-182-5p RGS5 2.36408084103818 2.60011457600281e-72 -1.26127104615759 8.15092708402597e-17 MirTarget -0.116636809474083 0.00151288205994257 NA NA NA hsa-miR-141-3p RGS7BP 2.99777540204168 1.26370498493024e-78 -3.08832484723279 1.36129686977447e-41 TargetScan;miRNATAP -0.526828492924082 1.566674089427e-31 NA NA NA hsa-miR-200a-3p RGS7BP 2.55218480823434 2.96135446816238e-51 -3.08832484723279 1.36129686977447e-41 miRNATAP -0.442831721651278 4.23883264781572e-23 NA NA NA hsa-miR-200a-5p RGS7BP 2.58844508672328 1.79650654234569e-56 -3.08832484723279 1.36129686977447e-41 MirTarget -0.415404379962564 1.81954986601427e-19 NA NA NA hsa-miR-429 RGS7BP 2.84108892259147 3.88520896426515e-64 -3.08832484723279 1.36129686977447e-41 miRanda -0.435701246413006 1.124212715865e-22 NA NA NA hsa-miR-335-5p RHBDF2 -2.61355235628987 2.6462884165886e-51 0.964981690155754 1.01925296223659e-25 miRNAWalker2_validate -0.127657842244014 2.12749301576645e-13 NA NA NA hsa-miR-139-5p RHBDL2 -3.25846663863766 2.62018989415003e-112 0.93429459716128 1.36626346276989e-11 miRanda -0.191913283107925 1.61460410421217e-11 NA NA NA hsa-miR-183-5p RHBDL3 2.95681814393872 1.09965777344285e-92 -0.900845711813341 4.8566155212511e-05 mirMAP -0.258408225807529 2.96222854324929e-08 NA NA NA hsa-miR-224-5p RHBDL3 -2.22249420723892 1.07787949391113e-18 -0.900845711813341 4.8566155212511e-05 mirMAP -0.122096438660271 3.56923152669604e-05 NA NA NA hsa-miR-429 RHBDL3 2.84108892259147 3.88520896426515e-64 -0.900845711813341 4.8566155212511e-05 miRNATAP -0.143448319038748 0.000662474375339106 NA NA NA hsa-miR-141-5p RHOBTB2 2.38411349683216 4.56310582620282e-58 -0.153829701163943 0.0709958502726741 mirMAP -0.100263235342085 3.36783904831511e-08 NA NA NA hsa-miR-511-5p RHOH -2.27545475897362 3.84085514050558e-36 0.95449646771927 1.46489117348312e-07 MirTarget -0.108704460273487 0.00108685469853726 NA NA NA hsa-miR-96-5p RHOJ 3.24596558166606 1.92296159041707e-98 -1.78538331819415 1.0089537162633e-56 TargetScan -0.363914502770735 1.18083787751048e-60 NA NA NA hsa-miR-21-5p RHOQ 2.32007501846389 3.08394781855554e-137 -1.35438478184297 3.37585411116795e-60 miRNAWalker2_validate -0.331156761026688 1.86377123477213e-35 NA NA NA hsa-miR-375 RHOQ 2.09893673049766 1.68351780396203e-16 -1.35438478184297 3.37585411116795e-60 miRNAWalker2_validate;miRanda -0.125276909188229 3.64884172005162e-28 NA NA NA hsa-miR-96-5p RHOQ 3.24596558166606 1.92296159041707e-98 -1.35438478184297 3.37585411116795e-60 TargetScan -0.213861197929473 8.17543759369673e-37 NA NA NA hsa-miR-10b-5p RHOT2 -2.10996264627796 7.36811595736367e-72 1.05028137655666 4.12350175107646e-28 mirMAP -0.215060776500948 9.18869289559276e-17 NA NA NA hsa-miR-429 RIC3 2.84108892259147 3.88520896426515e-64 -2.77409874549096 7.75015062849707e-27 miRNATAP -0.262047063717341 1.9431557522699e-07 NA NA NA hsa-miR-141-3p RIMBP2 2.99777540204168 1.26370498493024e-78 -2.66086302484182 1.10626009172396e-31 mirMAP -0.497128596846083 4.02879899288475e-29 NA NA NA hsa-miR-182-5p RIMBP2 2.36408084103818 2.60011457600281e-72 -2.66086302484182 1.10626009172396e-31 mirMAP;miRNATAP -0.462301491076435 6.19382713819109e-17 NA NA NA hsa-miR-183-5p RIMBP2 2.95681814393872 1.09965777344285e-92 -2.66086302484182 1.10626009172396e-31 MirTarget;miRNATAP -0.492731460317749 2.5447325452954e-24 NA NA NA hsa-miR-200a-3p RIMBP2 2.55218480823434 2.96135446816238e-51 -2.66086302484182 1.10626009172396e-31 mirMAP -0.424239841228376 4.81108335516607e-22 NA NA NA hsa-miR-429 RIMBP2 2.84108892259147 3.88520896426515e-64 -2.66086302484182 1.10626009172396e-31 miRNATAP -0.448483162894796 6.13968378063099e-25 NA NA NA hsa-miR-96-5p RIMBP2 3.24596558166606 1.92296159041707e-98 -2.66086302484182 1.10626009172396e-31 miRNATAP -0.49144522538938 1.7235353154647e-27 NA NA NA hsa-miR-200a-5p RIMKLB 2.58844508672328 1.79650654234569e-56 -0.826556118490011 4.58785373746228e-25 MirTarget -0.104337755615509 5.41403901334543e-11 NA NA NA hsa-miR-200b-3p RIMKLB 2.11744072703209 1.66710572104191e-43 -0.826556118490011 4.58785373746228e-25 MirTarget;TargetScan -0.124605782720432 4.76653153226331e-13 NA NA NA hsa-miR-429 RIMKLB 2.84108892259147 3.88520896426515e-64 -0.826556118490011 4.58785373746228e-25 MirTarget;miRanda;miRNATAP -0.117857520735019 1.65672965011281e-14 NA NA NA hsa-miR-200a-3p RIMS1 2.55218480823434 2.96135446816238e-51 -0.116643787448406 0.690079336554856 MirTarget -0.12601082422311 0.0239415058767093 NA NA NA hsa-miR-141-3p RIMS3 2.99777540204168 1.26370498493024e-78 -1.82635174452916 4.12617185172086e-37 mirMAP -0.196008779545818 1.15086723746033e-11 NA NA NA hsa-miR-182-5p RIMS3 2.36408084103818 2.60011457600281e-72 -1.82635174452916 4.12617185172086e-37 MirTarget;miRNATAP -0.307047730454269 2.1337625509872e-18 NA NA NA hsa-miR-183-5p RIMS3 2.95681814393872 1.09965777344285e-92 -1.82635174452916 4.12617185172086e-37 mirMAP -0.243389458690778 5.86825057113223e-15 NA NA NA hsa-miR-200a-3p RIMS3 2.55218480823434 2.96135446816238e-51 -1.82635174452916 4.12617185172086e-37 mirMAP -0.147132525285807 2.43452935051596e-07 NA NA NA hsa-miR-200b-3p RIMS3 2.11744072703209 1.66710572104191e-43 -1.82635174452916 4.12617185172086e-37 TargetScan -0.127360290157873 6.19043103475256e-05 NA NA NA hsa-miR-375 RIMS3 2.09893673049766 1.68351780396203e-16 -1.82635174452916 4.12617185172086e-37 miRNAWalker2_validate -0.193510645628903 1.08932944474403e-23 NA NA NA hsa-miR-429 RIMS3 2.84108892259147 3.88520896426515e-64 -1.82635174452916 4.12617185172086e-37 PITA;miRNATAP -0.138932151027579 9.36026960081076e-07 NA NA NA hsa-miR-96-5p RIMS3 3.24596558166606 1.92296159041707e-98 -1.82635174452916 4.12617185172086e-37 TargetScan -0.2744244321946 3.05998197498331e-21 NA NA NA hsa-miR-335-5p RIMS4 -2.61355235628987 2.6462884165886e-51 1.93936813754878 1.60005847788467e-09 mirMAP -0.129594287417175 0.0318413362025168 NA NA NA hsa-miR-200c-3p RIN2 2.07038651806183 6.84613386286599e-51 -0.13319809102269 0.125216128478784 miRNAWalker2_validate -0.107502630238496 9.09693498682217e-08 NA NA NA hsa-miR-182-5p RIN3 2.36408084103818 2.60011457600281e-72 -0.239519718607973 0.00440102571815542 mirMAP -0.199818707902056 1.13622292451699e-24 NA NA NA hsa-miR-21-5p RMND5A 2.32007501846389 3.08394781855554e-137 -0.325563309762363 5.38664625762123e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.230725919786101 4.5541830124258e-32 NA NA NA hsa-miR-429 RMST 2.84108892259147 3.88520896426515e-64 -2.44382192551357 5.91433025323596e-08 miRanda -0.156652593369361 0.0239887216162191 NA NA NA hsa-miR-335-5p RNASE2 -2.61355235628987 2.6462884165886e-51 1.15701811944708 2.76406180897657e-16 miRNAWalker2_validate -0.12382814075781 3.38740302909616e-06 NA NA NA hsa-miR-200c-3p RNASEL 2.07038651806183 6.84613386286599e-51 -0.213544684568127 0.00459443349667082 MirTarget -0.110324450999897 2.34215535535053e-10 NA NA NA hsa-miR-200b-3p RND3 2.11744072703209 1.66710572104191e-43 -1.70606216262212 4.40038671490463e-36 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.198068196895994 3.25777991523227e-11 26935796 MicroRNA 200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE cervical and endocervical cancer hsa-miR-200c-3p RND3 2.07038651806183 6.84613386286599e-51 -1.70606216262212 4.40038671490463e-36 MirTarget;miRNATAP -0.267277520719072 2.46841389713331e-16 23821457 MicroRNA 200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE gastric cancer hsa-miR-429 RND3 2.84108892259147 3.88520896426515e-64 -1.70606216262212 4.40038671490463e-36 MirTarget;PITA;miRanda;miRNATAP -0.208480464114138 3.81057770723433e-15 NA NA NA hsa-miR-96-5p RND3 3.24596558166606 1.92296159041707e-98 -1.70606216262212 4.40038671490463e-36 TargetScan -0.318842557821535 5.0912947356405e-32 NA NA NA hsa-miR-21-5p RNF11 2.32007501846389 3.08394781855554e-137 -0.514510399894388 4.16557739659009e-17 miRNAWalker2_validate -0.207707905814412 1.86121810116098e-28 NA NA NA hsa-miR-21-5p RNF111 2.32007501846389 3.08394781855554e-137 -0.373520088810509 3.83879874193643e-08 miRNATAP -0.149067914864918 1.40190259258715e-12 NA NA NA hsa-miR-21-3p RNF128 2.17476065946878 5.15299442583591e-75 -1.38675760515491 1.39751475946132e-11 MirTarget -0.239020232675442 1.16762632242078e-05 NA NA NA hsa-miR-429 RNF128 2.84108892259147 3.88520896426515e-64 -1.38675760515491 1.39751475946132e-11 miRanda -0.114520123073205 0.00361770789523049 NA NA NA hsa-miR-429 RNF144A 2.84108892259147 3.88520896426515e-64 -0.638478312619122 9.22524840231119e-09 miRanda -0.172008572566887 1.63514115898349e-16 NA NA NA hsa-miR-141-3p RNF145 2.99777540204168 1.26370498493024e-78 -1.20951940062058 4.13842717523461e-27 MirTarget;TargetScan;miRNATAP -0.198722332291963 2.009833708129e-19 NA NA NA hsa-miR-200a-3p RNF145 2.55218480823434 2.96135446816238e-51 -1.20951940062058 4.13842717523461e-27 MirTarget;miRNATAP -0.205749004274111 1.45296311190587e-21 NA NA NA hsa-miR-429 RNF145 2.84108892259147 3.88520896426515e-64 -1.20951940062058 4.13842717523461e-27 miRanda;miRNATAP -0.183110350225735 1.88757116880177e-17 NA NA NA hsa-miR-21-3p RNF146 2.17476065946878 5.15299442583591e-75 -0.397746120464754 8.21485889424071e-16 MirTarget -0.10009346316642 1.33934063036706e-14 NA NA NA hsa-miR-182-5p RNF157 2.36408084103818 2.60011457600281e-72 -2.00541806985687 4.60846624301632e-31 mirMAP -0.296310643377824 2.54516014986454e-12 NA NA NA hsa-miR-200a-3p RNF168 2.55218480823434 2.96135446816238e-51 -0.508709890368149 4.19269847678057e-05 MirTarget -0.114227451053639 1.38720936170538e-06 NA NA NA hsa-miR-200b-3p RNF168 2.11744072703209 1.66710572104191e-43 -0.508709890368149 4.19269847678057e-05 MirTarget -0.119947320510893 5.2715655177743e-06 NA NA NA hsa-miR-429 RNF168 2.84108892259147 3.88520896426515e-64 -0.508709890368149 4.19269847678057e-05 MirTarget -0.101500182801453 1.61433311571773e-05 NA NA NA hsa-miR-429 RNF180 2.84108892259147 3.88520896426515e-64 -1.82675056040498 1.17639502328219e-42 miRanda;miRNATAP -0.290934903408219 1.29002775763103e-29 NA NA NA hsa-miR-21-5p RNF182 2.32007501846389 3.08394781855554e-137 -1.30295817553077 1.81742800137884e-09 MirTarget -0.305573934243 6.92453690347356e-06 NA NA NA hsa-miR-429 RNF186 2.84108892259147 3.88520896426515e-64 -4.05601090899449 1.18356274126591e-50 miRanda -0.38552988684743 9.69375617384976e-13 NA NA NA hsa-miR-335-5p RNF187 -2.61355235628987 2.6462884165886e-51 1.01633369097037 2.51780917868843e-52 mirMAP -0.130254834489929 4.32715475493157e-24 NA NA NA hsa-miR-99a-5p RNF187 -2.25079447371102 1.14086813185885e-54 1.01633369097037 2.51780917868843e-52 miRNAWalker2_validate -0.1865156533329 6.00000687641238e-35 NA NA NA hsa-miR-182-5p RNF212 2.36408084103818 2.60011457600281e-72 -1.59289337322393 1.21594108260693e-10 MirTarget -0.421944387499785 7.78290177157833e-13 NA NA NA hsa-miR-141-3p RNF217 2.99777540204168 1.26370498493024e-78 -1.36758471161392 1.37533511512395e-21 mirMAP -0.241595829055983 6.70385753017944e-18 NA NA NA hsa-miR-182-5p RNF217 2.36408084103818 2.60011457600281e-72 -1.36758471161392 1.37533511512395e-21 mirMAP -0.319733065659236 9.5111443064145e-21 NA NA NA hsa-miR-200a-3p RNF217 2.55218480823434 2.96135446816238e-51 -1.36758471161392 1.37533511512395e-21 mirMAP -0.237702839406249 5.35819185620001e-18 NA NA NA hsa-miR-200a-5p RNF217 2.58844508672328 1.79650654234569e-56 -1.36758471161392 1.37533511512395e-21 mirMAP -0.185089139965653 7.41984813073598e-11 NA NA NA hsa-miR-429 RNF217 2.84108892259147 3.88520896426515e-64 -1.36758471161392 1.37533511512395e-21 miRanda -0.220086843221332 9.29680373918769e-16 NA NA NA hsa-miR-96-5p RNF217 3.24596558166606 1.92296159041707e-98 -1.36758471161392 1.37533511512395e-21 TargetScan -0.288156553443513 2.07258254819299e-24 NA NA NA hsa-miR-139-5p RNF7 -3.25846663863766 2.62018989415003e-112 0.472914316532076 2.93498430690553e-17 miRanda -0.106231950631734 1.82752405286069e-20 NA NA NA hsa-miR-429 ROBO1 2.84108892259147 3.88520896426515e-64 -0.712537667984659 2.40417465472548e-08 miRanda;miRNATAP -0.21875107378067 4.5339353293762e-20 NA NA NA hsa-miR-107 ROCK1 0.678998026350662 2.56224148930538e-16 -0.577010438503248 1.15807774989766e-11 miRanda -0.214652817656713 7.4445514442289e-10 NA NA NA hsa-miR-429 ROCK1 2.84108892259147 3.88520896426515e-64 -0.577010438503248 1.15807774989766e-11 miRanda -0.107368538530982 2.74283719948915e-11 NA NA NA hsa-miR-200b-3p ROCK2 2.11744072703209 1.66710572104191e-43 -1.42053003829191 2.83260805693116e-25 TargetScan -0.238045362418837 5.70621727270586e-16 NA NA NA hsa-miR-340-5p ROCK2 1.0857159627596 4.94471062546756e-24 -1.42053003829191 2.83260805693116e-25 mirMAP -0.395127263389571 3.35868529258436e-20 NA NA NA hsa-miR-429 ROCK2 2.84108892259147 3.88520896426515e-64 -1.42053003829191 2.83260805693116e-25 PITA;miRanda;miRNATAP -0.205818358236693 4.93110698663187e-15 NA NA NA hsa-miR-21-5p ROR1 2.32007501846389 3.08394781855554e-137 -1.92875116490072 3.80085449134659e-21 miRNATAP -0.434393200893694 1.79063796146941e-11 NA NA NA hsa-miR-429 ROR1 2.84108892259147 3.88520896426515e-64 -1.92875116490072 3.80085449134659e-21 miRanda -0.358487191658964 2.54470445344887e-20 NA NA NA hsa-miR-335-5p ROR2 -2.61355235628987 2.6462884165886e-51 0.842642951628805 6.67569203229852e-10 miRNAWalker2_validate -0.16899767129334 2.58146686050354e-11 NA NA NA hsa-miR-486-5p ROR2 -3.87258704301474 1.22658629378451e-80 0.842642951628805 6.67569203229852e-10 miRanda -0.164748821586023 1.29503377838308e-15 NA NA NA hsa-miR-141-3p RORA 2.99777540204168 1.26370498493024e-78 -1.02145593857356 1.72079387585623e-26 MirTarget;TargetScan;miRNATAP -0.199558706164586 1.01161812914389e-26 NA NA NA hsa-miR-183-5p RORA 2.95681814393872 1.09965777344285e-92 -1.02145593857356 1.72079387585623e-26 miRNATAP -0.202379214105436 2.15240043070406e-23 NA NA NA hsa-miR-200a-3p RORA 2.55218480823434 2.96135446816238e-51 -1.02145593857356 1.72079387585623e-26 MirTarget;miRNATAP -0.150615063120472 4.81150009032588e-16 NA NA NA hsa-miR-200a-5p RORA 2.58844508672328 1.79650654234569e-56 -1.02145593857356 1.72079387585623e-26 MirTarget;miRNATAP -0.134724763863688 1.71156454893748e-12 NA NA NA hsa-miR-21-3p RORA 2.17476065946878 5.15299442583591e-75 -1.02145593857356 1.72079387585623e-26 mirMAP -0.173683734277545 1.58425065828725e-11 NA NA NA hsa-miR-429 RORA 2.84108892259147 3.88520896426515e-64 -1.02145593857356 1.72079387585623e-26 miRNATAP -0.178291111297733 1.73102629046183e-22 NA NA NA hsa-miR-429 RORB 2.84108892259147 3.88520896426515e-64 -1.45513468316292 1.72903316036044e-10 miRanda -0.343337917590084 1.3172628911866e-15 NA NA NA hsa-miR-141-3p RPH3AL 2.99777540204168 1.26370498493024e-78 -0.532864021447757 0.000141948146978237 TargetScan;miRNATAP -0.111449073586394 4.29528394957143e-05 NA NA NA hsa-miR-139-5p RPL22L1 -3.25846663863766 2.62018989415003e-112 0.468140615717082 7.55344996792651e-06 miRanda -0.102169660725594 2.07484517306164e-06 NA NA NA hsa-miR-182-5p RPL5 2.36408084103818 2.60011457600281e-72 -0.579090460888972 5.56068651339036e-17 miRNAWalker2_validate -0.116405321607349 2.1620553244855e-12 NA NA NA hsa-miR-375 RPRM 2.09893673049766 1.68351780396203e-16 -0.339849576303362 0.160381920538011 miRanda -0.126176516126823 7.46235837107678e-05 NA NA NA hsa-miR-99a-5p RPS26 -2.25079447371102 1.14086813185885e-54 0.488265192748664 5.56805151166031e-06 miRNAWalker2_validate -0.102143155433892 1.84721772336762e-05 NA NA NA hsa-miR-139-5p RPS6KA1 -3.25846663863766 2.62018989415003e-112 1.00256510904029 1.46599111482776e-34 miRanda -0.156690112707771 7.04064981880923e-20 NA NA NA hsa-miR-200b-3p RPS6KA2 2.11744072703209 1.66710572104191e-43 -1.06112701609507 1.34339346025472e-29 TargetScan -0.19593222828491 2.13416782438513e-22 NA NA NA hsa-miR-200c-3p RPS6KA2 2.07038651806183 6.84613386286599e-51 -1.06112701609507 1.34339346025472e-29 miRNATAP -0.281022132531582 1.82177016356237e-38 NA NA NA hsa-miR-21-3p RPS6KA2 2.17476065946878 5.15299442583591e-75 -1.06112701609507 1.34339346025472e-29 MirTarget -0.24334264336363 1.98040233570223e-22 NA NA NA hsa-miR-429 RPS6KA2 2.84108892259147 3.88520896426515e-64 -1.06112701609507 1.34339346025472e-29 miRanda;miRNATAP -0.191117874968675 1.07705854301622e-26 NA NA NA hsa-miR-183-5p RPS6KA3 2.95681814393872 1.09965777344285e-92 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.221655186837094 1.11615961728505e-20 NA NA NA hsa-miR-200b-3p RPS6KA3 2.11744072703209 1.66710572104191e-43 -1.37237205082117 2.11044411412942e-35 MirTarget;TargetScan -0.241869137597393 3.09939082839428e-24 NA NA NA hsa-miR-200c-3p RPS6KA3 2.07038651806183 6.84613386286599e-51 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.26058220909184 2.84165141998717e-23 NA NA NA hsa-miR-21-5p RPS6KA3 2.32007501846389 3.08394781855554e-137 -1.37237205082117 2.11044411412942e-35 miRNAWalker2_validate;mirMAP;miRNATAP -0.318123624363205 1.65398865078165e-19 NA NA NA hsa-miR-429 RPS6KA3 2.84108892259147 3.88520896426515e-64 -1.37237205082117 2.11044411412942e-35 MirTarget;PITA;miRanda;miRNATAP -0.220289857421514 3.31100891599358e-25 NA NA NA hsa-miR-335-5p RPUSD1 -2.61355235628987 2.6462884165886e-51 1.45430691999879 2.92528090344684e-53 mirMAP -0.187727947285327 8.96108144051898e-25 NA NA NA hsa-miR-21-3p RRAGB 2.17476065946878 5.15299442583591e-75 -0.181168480036266 0.00531281477590442 MirTarget -0.101264984318921 2.35670171309444e-09 NA NA NA hsa-miR-21-5p RRAGC 2.32007501846389 3.08394781855554e-137 -0.755786416142128 6.43029191974687e-15 miRNAWalker2_validate -0.260892436864086 4.61156448903526e-18 NA NA NA hsa-miR-182-5p RRAGD 2.36408084103818 2.60011457600281e-72 -1.55431301476693 3.93587241444543e-32 mirMAP -0.405336305444052 1.08174418348156e-38 NA NA NA hsa-miR-429 RRAGD 2.84108892259147 3.88520896426515e-64 -1.55431301476693 3.93587241444543e-32 miRNATAP -0.218679806782559 8.75244960682989e-18 NA NA NA hsa-miR-429 RRAS2 2.84108892259147 3.88520896426515e-64 -1.34328469535129 7.92387097337765e-28 PITA;miRanda -0.157362353521412 3.91853907751419e-11 NA NA NA hsa-miR-335-5p RRBP1 -2.61355235628987 2.6462884165886e-51 0.770656716424769 3.70077378186423e-19 miRNAWalker2_validate -0.145311954931141 1.06720602364095e-19 NA NA NA hsa-miR-375 RRN3P2 2.09893673049766 1.68351780396203e-16 -0.257078799540809 0.0170125916082822 miRanda -0.117847042100417 2.96346601745251e-17 NA NA NA hsa-miR-145-5p RRP7A -2.62703571936687 7.64402900188551e-88 0.515771943484365 2.10349283417685e-08 MirTarget -0.128643745400855 1.7340160303388e-09 NA NA NA hsa-miR-21-5p RSBN1 2.32007501846389 3.08394781855554e-137 -0.46855948964557 5.08459791485839e-13 miRNATAP -0.210119054420049 3.66501148874656e-26 NA NA NA hsa-miR-21-5p RSF1 2.32007501846389 3.08394781855554e-137 -0.208076499612155 0.0317730155068098 miRNAWalker2_validate -0.16893371246655 1.7636669179261e-08 NA NA NA hsa-miR-141-3p RSPO3 2.99777540204168 1.26370498493024e-78 -2.999908875854 9.15620294188119e-63 TargetScan -0.522397745128962 7.15675508960835e-49 NA NA NA hsa-miR-375 RSU1 2.09893673049766 1.68351780396203e-16 -0.387064764730159 4.65594507170923e-06 miRanda -0.151351458433912 1.77092495673847e-46 NA NA NA hsa-miR-335-5p RTBDN -2.61355235628987 2.6462884165886e-51 3.27135689987135 2.87510975137428e-22 miRNAWalker2_validate -0.246958131443889 0.000119853273909884 NA NA NA hsa-miR-145-5p RTKN -2.62703571936687 7.64402900188551e-88 1.29492093513268 4.15162188834918e-51 miRNAWalker2_validate;MirTarget;miRNATAP -0.2656003480696 5.30374903814574e-39 19360360 miR 145 inhibits breast cancer cell growth through RTKN; Subsequently RTKN is identified as a potential miR-145 target by bioinformatics; Using reporter constructs we show that the RTKN 3' untranslated region 3'UTR carries the directly binding site of miR-145; Additionally overexpression of miR-145 in MCF-7 reduces RTKN protein expression as well as mRNA level; Taken together we propose that loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN breast cancer hsa-miR-10b-5p RTKN2 -2.10996264627796 7.36811595736367e-72 2.0067852030241 8.87487047857275e-51 miRNAWalker2_validate -0.440489946878946 1.84994697124521e-33 NA NA NA hsa-miR-139-5p RTKN2 -3.25846663863766 2.62018989415003e-112 2.0067852030241 8.87487047857275e-51 miRanda -0.398710079994439 7.52332694429049e-47 NA NA NA hsa-miR-429 RTN1 2.84108892259147 3.88520896426515e-64 -1.24297776796299 6.9409530106916e-11 miRNATAP -0.180633130011006 6.69974539621116e-07 NA NA NA hsa-miR-21-5p RTN4 2.32007501846389 3.08394781855554e-137 -0.601034406966253 3.97552525003937e-25 miRNAWalker2_validate;miRTarBase -0.190348578635845 5.32438743284111e-26 NA NA NA hsa-miR-139-5p RTN4IP1 -3.25846663863766 2.62018989415003e-112 0.262629336071902 0.001321929629982 miRanda -0.111273554487385 2.48936216176595e-11 NA NA NA hsa-miR-182-5p RUNDC3B 2.36408084103818 2.60011457600281e-72 -2.07495773232627 9.0745448708427e-48 miRNATAP -0.22940331081109 1.48825310460547e-10 NA NA NA hsa-miR-429 RUNDC3B 2.84108892259147 3.88520896426515e-64 -2.07495773232627 9.0745448708427e-48 miRanda -0.319288446616292 1.03660759606566e-30 NA NA NA hsa-miR-96-5p RUNDC3B 3.24596558166606 1.92296159041707e-98 -2.07495773232627 9.0745448708427e-48 MirTarget;TargetScan;miRNATAP -0.320510284278996 2.3151659743412e-28 NA NA NA hsa-miR-182-5p RUNX1T1 2.36408084103818 2.60011457600281e-72 -2.57048990739789 4.6896723401076e-41 mirMAP -0.45367987162484 3.63838290946969e-22 NA NA NA hsa-miR-183-5p RUNX1T1 2.95681814393872 1.09965777344285e-92 -2.57048990739789 4.6896723401076e-41 miRNATAP -0.474974376790519 4.32813984121944e-31 NA NA NA hsa-miR-200b-3p RUNX1T1 2.11744072703209 1.66710572104191e-43 -2.57048990739789 4.6896723401076e-41 TargetScan -0.525102670723429 8.69731410815183e-38 NA NA NA hsa-miR-429 RUNX1T1 2.84108892259147 3.88520896426515e-64 -2.57048990739789 4.6896723401076e-41 miRNATAP -0.508770880173075 5.53023503447058e-45 NA NA NA hsa-miR-139-5p RUNX2 -3.25846663863766 2.62018989415003e-112 1.19201647967447 5.60453881730697e-20 miRanda -0.238369454543818 7.59740624272695e-19 NA NA NA hsa-miR-335-5p RUNX2 -2.61355235628987 2.6462884165886e-51 1.19201647967447 5.60453881730697e-20 miRNAWalker2_validate;miRTarBase -0.170393498029752 3.3756096636227e-12 NA NA NA hsa-miR-486-5p RUNX2 -3.87258704301474 1.22658629378451e-80 1.19201647967447 5.60453881730697e-20 miRanda -0.18404642960456 1.44561100215654e-20 NA NA NA hsa-miR-200b-3p RUSC2 2.11744072703209 1.66710572104191e-43 -0.604983797869647 5.6219766920266e-16 TargetScan -0.107269201640875 1.71502756104415e-11 NA NA NA hsa-miR-200c-3p RUSC2 2.07038651806183 6.84613386286599e-51 -0.604983797869647 5.6219766920266e-16 miRNATAP -0.173276147457491 9.6051615693087e-24 NA NA NA hsa-miR-429 RUSC2 2.84108892259147 3.88520896426515e-64 -0.604983797869647 5.6219766920266e-16 PITA;miRanda;miRNATAP -0.108346503683347 2.17547080356327e-14 NA NA NA hsa-miR-140-5p RUVBL1 -0.755971041589807 9.68060922934542e-14 1.08405592163913 6.7091844654157e-50 miRanda -0.115192679042016 8.12213333695103e-06 NA NA NA hsa-miR-34c-5p RUVBL1 -0.0896438810345765 0.557016551646841 1.08405592163913 6.7091844654157e-50 miRanda -0.100087979601338 8.64529686751099e-09 NA NA NA hsa-miR-141-5p RYR2 2.38411349683216 4.56310582620282e-58 -0.895189916284699 1.42900516050702e-05 miRNATAP -0.271587485853281 7.54110243331901e-10 NA NA NA hsa-miR-375 RYR2 2.09893673049766 1.68351780396203e-16 -0.895189916284699 1.42900516050702e-05 miRanda -0.122559203532273 6.82386248367019e-06 NA NA NA hsa-miR-429 S1PR1 2.84108892259147 3.88520896426515e-64 -2.1497007752679 6.02363932653677e-64 miRanda;miRNATAP -0.376045985244141 2.95807890553499e-53 NA NA NA hsa-miR-96-5p S1PR1 3.24596558166606 1.92296159041707e-98 -2.1497007752679 6.02363932653677e-64 TargetScan -0.403332331520889 1.33963091184999e-56 NA NA NA hsa-miR-21-5p SACM1L 2.32007501846389 3.08394781855554e-137 -0.332441093472275 9.3174647468081e-09 miRNAWalker2_validate -0.212024177398943 4.75997508608528e-34 NA NA NA hsa-miR-183-5p SACS 2.95681814393872 1.09965777344285e-92 -1.56917141333942 3.22635024794334e-37 MirTarget;miRNATAP -0.255694719613879 4.89585397747982e-22 NA NA NA hsa-miR-486-5p SALL1 -3.87258704301474 1.22658629378451e-80 -0.348151775813103 0.0746323035364776 miRanda -0.120588959731648 4.61937739034066e-05 NA NA NA hsa-miR-335-5p SALL4 -2.61355235628987 2.6462884165886e-51 2.64528493469248 8.56351214441136e-51 miRNAWalker2_validate -0.305774420946792 4.09499580527559e-19 NA NA NA hsa-miR-145-5p SAMD12 -2.62703571936687 7.64402900188551e-88 0.749718148942251 7.14387599251026e-08 miRNATAP -0.148442909122046 4.76308905195642e-06 NA NA NA hsa-miR-486-5p SAMD12 -3.87258704301474 1.22658629378451e-80 0.749718148942251 7.14387599251026e-08 miRanda -0.162850656385091 8.24466061567922e-15 NA NA NA hsa-miR-141-5p SAMD4A 2.38411349683216 4.56310582620282e-58 -1.7968635515046 2.10294718067867e-53 mirMAP -0.394392130602174 6.09796518541311e-56 NA NA NA hsa-miR-182-5p SAMD4A 2.36408084103818 2.60011457600281e-72 -1.7968635515046 2.10294718067867e-53 MirTarget;miRNATAP -0.416228617761056 4.79618425070516e-50 NA NA NA hsa-miR-183-5p SAMD4A 2.95681814393872 1.09965777344285e-92 -1.7968635515046 2.10294718067867e-53 MirTarget;miRNATAP -0.373407673821346 1.1919527350263e-51 NA NA NA hsa-miR-200a-3p SAMD4A 2.55218480823434 2.96135446816238e-51 -1.7968635515046 2.10294718067867e-53 miRNATAP -0.300117305654887 6.27824661583868e-40 NA NA NA hsa-miR-375 SAMD4A 2.09893673049766 1.68351780396203e-16 -1.7968635515046 2.10294718067867e-53 miRNAWalker2_validate;miRanda -0.170903928596782 9.87858622535318e-27 NA NA NA hsa-miR-429 SAMD4A 2.84108892259147 3.88520896426515e-64 -1.7968635515046 2.10294718067867e-53 miRNATAP -0.283035146821723 8.4399794993147e-36 NA NA NA hsa-miR-182-5p SAMD5 2.36408084103818 2.60011457600281e-72 -3.39073020822628 1.45517228933151e-64 MirTarget -0.550138235750542 3.73777276965171e-28 NA NA NA hsa-miR-21-5p SAMD5 2.32007501846389 3.08394781855554e-137 -3.39073020822628 1.45517228933151e-64 miRNAWalker2_validate -0.716846378058606 6.19437362584202e-28 NA NA NA hsa-miR-429 SAMD5 2.84108892259147 3.88520896426515e-64 -3.39073020822628 1.45517228933151e-64 miRanda -0.390634434878663 1.76756044374427e-22 NA NA NA hsa-miR-141-3p SAMD8 2.99777540204168 1.26370498493024e-78 -1.02596634412093 2.61875625350706e-22 MirTarget;TargetScan;miRNATAP -0.182160884804826 1.12052684348881e-18 NA NA NA hsa-miR-200a-3p SAMD8 2.55218480823434 2.96135446816238e-51 -1.02596634412093 2.61875625350706e-22 MirTarget;miRNATAP -0.171297758446296 3.17805349020134e-17 NA NA NA hsa-miR-200b-3p SAMD8 2.11744072703209 1.66710572104191e-43 -1.02596634412093 2.61875625350706e-22 TargetScan -0.197565264113326 1.84773250583766e-18 NA NA NA hsa-miR-21-3p SAMD8 2.17476065946878 5.15299442583591e-75 -1.02596634412093 2.61875625350706e-22 MirTarget -0.143995925934936 3.9429930706078e-07 NA NA NA hsa-miR-21-5p SAMD8 2.32007501846389 3.08394781855554e-137 -1.02596634412093 2.61875625350706e-22 mirMAP -0.358979847151263 4.88149297609557e-28 NA NA NA hsa-miR-429 SAMD8 2.84108892259147 3.88520896426515e-64 -1.02596634412093 2.61875625350706e-22 miRNATAP -0.183931632553076 5.27790356169024e-20 NA NA NA hsa-miR-141-5p SAMHD1 2.38411349683216 4.56310582620282e-58 -0.608489761651589 7.00009784878489e-07 mirMAP -0.105808286448792 6.27893578793495e-05 NA NA NA hsa-miR-10b-5p SAP30BP -2.10996264627796 7.36811595736367e-72 0.307041253778928 7.48116734658736e-07 MirTarget -0.144285776467964 7.11998261731468e-19 NA NA NA hsa-miR-96-5p SAP30L 3.24596558166606 1.92296159041707e-98 -0.735333113512773 7.21756711523264e-35 TargetScan -0.107939125739045 3.03555335362719e-19 NA NA NA hsa-miR-21-5p SAR1A 2.32007501846389 3.08394781855554e-137 -0.18285075854808 0.000167851775759444 miRNAWalker2_validate -0.100987634950651 1.50952128914346e-11 NA NA NA hsa-miR-182-5p SARM1 2.36408084103818 2.60011457600281e-72 -0.621717049421425 7.36140580232588e-06 mirMAP -0.114629575511754 0.000548562372493025 NA NA NA hsa-miR-96-5p SARM1 3.24596558166606 1.92296159041707e-98 -0.621717049421425 7.36140580232588e-06 mirMAP -0.12175903933298 9.24417621564873e-06 NA NA NA hsa-miR-139-5p SARNP -3.25846663863766 2.62018989415003e-112 0.485222442801035 1.16299844706443e-17 miRanda -0.110132324643119 2.23902445062223e-21 NA NA NA hsa-miR-200b-3p SASH1 2.11744072703209 1.66710572104191e-43 -1.69232748002298 1.81957068409705e-39 MirTarget -0.254770467298297 1.09943557277983e-19 NA NA NA hsa-miR-200c-3p SASH1 2.07038651806183 6.84613386286599e-51 -1.69232748002298 1.81957068409705e-39 MirTarget -0.288172511480447 8.59289682608382e-21 NA NA NA hsa-miR-21-5p SASH1 2.32007501846389 3.08394781855554e-137 -1.69232748002298 1.81957068409705e-39 miRNAWalker2_validate;MirTarget -0.459482061655079 1.48929633699321e-29 NA NA NA hsa-miR-429 SASH1 2.84108892259147 3.88520896426515e-64 -1.69232748002298 1.81957068409705e-39 MirTarget;miRanda;miRNATAP -0.227754149040707 9.97959539751018e-20 NA NA NA hsa-miR-21-5p SATB1 2.32007501846389 3.08394781855554e-137 -1.56127568524025 3.5724533657613e-30 MirTarget;miRNATAP -0.367776335653766 2.454140715956e-17 27107063 SATB1 is Down regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR 21 5p Overexpression and Poor Prognosis; This study aimed to determine the expression levels of SATB1 as well as miR-21-5p -the post-transcriptional repressor of SATB1 expression- in clear cell renal cell carcinoma ccRCC and to investigate their association with the progression of ccRCC; Immunohistochemistry and quantitative polymerase chain reaction were used to assess the expression of SATB1 protein and mRNA as well as miR-21-5p in tumor and matched normal kidney tissues collected from 56 ccRCC patients; SATB1 mRNA level was down-regulated in ccRCC tissue and inversely correlated with the content of miR-21-5p; Down-regulation of SATB1 mRNA and up-regulation of miR-21-5p were associated with shorter patient survival; Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p worse prognosis;progression;poor survival kidney renal cell cancer hsa-miR-182-5p SATB2 2.36408084103818 2.60011457600281e-72 -0.316308874394203 0.0233581925812678 miRNATAP -0.14194048364683 1.85906745660064e-05 24884732 Restoring SATB2 expression could reverse the effects of miR-182 on CRC cell proliferation and migration colorectal cancer hsa-miR-429 SATB2 2.84108892259147 3.88520896426515e-64 -0.316308874394203 0.0233581925812678 PITA;miRanda;miRNATAP -0.153562124447805 4.79345747155442e-09 NA NA NA hsa-miR-182-5p SBF2 2.36408084103818 2.60011457600281e-72 -1.15927913915641 8.05869400781941e-29 miRNATAP -0.162727760812065 1.55826399927169e-10 NA NA NA hsa-miR-429 SBF2 2.84108892259147 3.88520896426515e-64 -1.15927913915641 8.05869400781941e-29 miRanda;miRNATAP -0.194910997146675 1.13334052783229e-22 NA NA NA hsa-miR-96-5p SBF2 3.24596558166606 1.92296159041707e-98 -1.15927913915641 8.05869400781941e-29 miRNATAP -0.192261817984066 2.67402665795932e-20 NA NA NA hsa-miR-10b-5p SBK1 -2.10996264627796 7.36811595736367e-72 2.5929852346295 1.58376748573955e-74 mirMAP -0.520257749209387 2.35453560735087e-39 NA NA NA hsa-miR-139-5p SBK1 -3.25846663863766 2.62018989415003e-112 2.5929852346295 1.58376748573955e-74 PITA;miRanda -0.513859776869886 6.38927383537412e-68 NA NA NA hsa-miR-452-5p SBK1 -2.48486455572568 1.24430987974325e-33 2.5929852346295 1.58376748573955e-74 mirMAP -0.257312863885347 1.87628706310842e-26 NA NA NA hsa-miR-21-5p SBNO1 2.32007501846389 3.08394781855554e-137 -0.415971320705136 0.00712969390279438 mirMAP -0.247201602083685 2.57673313176957e-07 NA NA NA hsa-miR-21-3p SCAI 2.17476065946878 5.15299442583591e-75 -0.563760142630529 5.97756546904554e-15 MirTarget -0.144849677821488 2.7072166550293e-14 NA NA NA hsa-miR-145-5p SCAMP3 -2.62703571936687 7.64402900188551e-88 1.06092398239759 1.16725287486899e-53 MirTarget;miRNATAP -0.211323432014676 1.86893411797385e-38 NA NA NA hsa-miR-429 SCARA3 2.84108892259147 3.88520896426515e-64 -0.76592406230271 5.63837855830428e-09 miRNATAP -0.142543950395926 1.08978075727569e-08 NA NA NA hsa-miR-200b-3p SCD 2.11744072703209 1.66710572104191e-43 -0.986156765000191 5.50753282750432e-07 MirTarget;TargetScan -0.265877662991528 1.72102243290333e-10 NA NA NA hsa-miR-200c-3p SCD 2.07038651806183 6.84613386286599e-51 -0.986156765000191 5.50753282750432e-07 MirTarget;miRNATAP -0.190601860961146 3.57781186937903e-05 NA NA NA hsa-miR-429 SCD 2.84108892259147 3.88520896426515e-64 -0.986156765000191 5.50753282750432e-07 MirTarget;PITA;miRanda;miRNATAP -0.170998038611195 4.84422714712325e-06 NA NA NA hsa-miR-141-3p SCD5 2.99777540204168 1.26370498493024e-78 -0.626458922510552 2.15853670174057e-05 TargetScan -0.105227095511234 0.000251746117462131 NA NA NA hsa-miR-141-3p SCEL 2.99777540204168 1.26370498493024e-78 -1.41198681453485 5.03237774100658e-05 TargetScan -0.210301952939984 0.00197151358120157 NA NA NA hsa-miR-139-5p SCG2 -3.25846663863766 2.62018989415003e-112 1.91907745779374 2.47137768211596e-21 miRanda -0.134674702058716 0.00161679062975327 NA NA NA hsa-miR-486-5p SCG2 -3.87258704301474 1.22658629378451e-80 1.91907745779374 2.47137768211596e-21 miRanda;miRNATAP -0.117519522758293 0.000189612052071907 NA NA NA hsa-miR-429 SCG3 2.84108892259147 3.88520896426515e-64 -2.10145796531759 3.43292601513307e-13 miRNATAP -0.181434777250095 0.00107527054906144 NA NA NA hsa-miR-141-3p SCHIP1 2.99777540204168 1.26370498493024e-78 -1.03889489471923 7.51698487725528e-22 MirTarget;TargetScan -0.164884646086568 8.29040323820517e-15 NA NA NA hsa-miR-200a-3p SCHIP1 2.55218480823434 2.96135446816238e-51 -1.03889489471923 7.51698487725528e-22 MirTarget -0.133997805850028 1.61625334224757e-10 NA NA NA hsa-miR-200b-3p SCHIP1 2.11744072703209 1.66710572104191e-43 -1.03889489471923 7.51698487725528e-22 TargetScan -0.149438142582153 1.43924162350809e-10 NA NA NA hsa-miR-200c-3p SCHIP1 2.07038651806183 6.84613386286599e-51 -1.03889489471923 7.51698487725528e-22 miRNATAP -0.195608295610641 1.69420834697768e-14 NA NA NA hsa-miR-429 SCHIP1 2.84108892259147 3.88520896426515e-64 -1.03889489471923 7.51698487725528e-22 PITA;miRanda;miRNATAP -0.12246549552733 4.28623266994182e-09 NA NA NA hsa-miR-429 SCML1 2.84108892259147 3.88520896426515e-64 -1.00340292240876 1.55223826304722e-13 miRanda -0.185333589038496 6.77978816449102e-13 NA NA NA hsa-miR-21-5p SCML2 2.32007501846389 3.08394781855554e-137 -0.158331495689161 0.325217635043326 MirTarget;miRNATAP -0.181409503310777 0.000290066888741199 NA NA NA hsa-miR-429 SCML4 2.84108892259147 3.88520896426515e-64 -0.483390635241206 0.0205218901192533 miRanda -0.110079707612141 0.00539163281607954 NA NA NA hsa-miR-96-5p SCML4 3.24596558166606 1.92296159041707e-98 -0.483390635241206 0.0205218901192533 TargetScan -0.24074865042398 4.18981622011364e-09 NA NA NA hsa-miR-139-5p SCN1A -3.25846663863766 2.62018989415003e-112 0.743694894902573 0.0150562525914744 PITA;miRanda -0.190788648159018 0.00246914199276776 NA NA NA hsa-miR-210-3p SCN1B 2.38367203491819 3.73261999106754e-22 -0.291812974047642 0.0186274135718898 miRNAWalker2_validate -0.176564637122389 1.86991226089235e-27 NA NA NA hsa-miR-429 SCN1B 2.84108892259147 3.88520896426515e-64 -0.291812974047642 0.0186274135718898 miRNATAP -0.108562700769791 3.52322885112413e-06 NA NA NA hsa-miR-182-5p SCN2A 2.36408084103818 2.60011457600281e-72 -3.32315290330292 2.78847355111384e-40 miRNATAP -0.565948072791109 2.59592906450711e-20 NA NA NA hsa-miR-200b-3p SCN2A 2.11744072703209 1.66710572104191e-43 -3.32315290330292 2.78847355111384e-40 MirTarget;TargetScan -0.351310752333557 2.07724084947455e-10 NA NA NA hsa-miR-200c-3p SCN2A 2.07038651806183 6.84613386286599e-51 -3.32315290330292 2.78847355111384e-40 MirTarget;miRNATAP -0.418155386863787 5.43509582986909e-12 NA NA NA hsa-miR-429 SCN2A 2.84108892259147 3.88520896426515e-64 -3.32315290330292 2.78847355111384e-40 MirTarget;miRanda;miRNATAP -0.414018197403135 2.56614249672458e-17 NA NA NA hsa-miR-96-5p SCN2A 3.24596558166606 1.92296159041707e-98 -3.32315290330292 2.78847355111384e-40 TargetScan;miRNATAP -0.564727041850482 2.64592690604943e-29 NA NA NA hsa-miR-141-3p SCN2B 2.99777540204168 1.26370498493024e-78 -3.86249794050417 7.57828818937623e-49 MirTarget;miRNATAP -0.801685871012867 2.57898454076002e-56 NA NA NA hsa-miR-200a-3p SCN2B 2.55218480823434 2.96135446816238e-51 -3.86249794050417 7.57828818937623e-49 MirTarget;miRNATAP -0.626929465635717 1.67758276020873e-34 NA NA NA hsa-miR-375 SCN2B 2.09893673049766 1.68351780396203e-16 -3.86249794050417 7.57828818937623e-49 miRNATAP -0.157270695989515 1.89932729075785e-05 NA NA NA hsa-miR-182-5p SCN3A 2.36408084103818 2.60011457600281e-72 -4.0564772332002 1.56940161813981e-68 miRNATAP -0.623697116597284 1.35000686720418e-26 NA NA NA hsa-miR-183-5p SCN3A 2.95681814393872 1.09965777344285e-92 -4.0564772332002 1.56940161813981e-68 miRNATAP -0.700379559306922 1.10106690147629e-43 NA NA NA hsa-miR-200b-3p SCN3A 2.11744072703209 1.66710572104191e-43 -4.0564772332002 1.56940161813981e-68 mirMAP -0.558060398300087 7.14821215686193e-27 NA NA NA hsa-miR-200c-3p SCN3A 2.07038651806183 6.84613386286599e-51 -4.0564772332002 1.56940161813981e-68 mirMAP -0.676853275901311 8.17048883620064e-33 NA NA NA hsa-miR-429 SCN3A 2.84108892259147 3.88520896426515e-64 -4.0564772332002 1.56940161813981e-68 PITA;miRanda;mirMAP;miRNATAP -0.600080777813446 1.95653358490526e-39 NA NA NA hsa-miR-96-5p SCN3A 3.24596558166606 1.92296159041707e-98 -4.0564772332002 1.56940161813981e-68 TargetScan;miRNATAP -0.695367483988279 2.03683592427476e-49 NA NA NA hsa-miR-200b-3p SCN3B 2.11744072703209 1.66710572104191e-43 -2.98039696453848 3.54121421070465e-48 TargetScan -0.479929246186831 5.79685044862697e-27 NA NA NA hsa-miR-429 SCN3B 2.84108892259147 3.88520896426515e-64 -2.98039696453848 3.54121421070465e-48 miRanda;miRNATAP -0.505205412711015 7.80106365079512e-38 NA NA NA hsa-miR-200a-3p SCN4A 2.55218480823434 2.96135446816238e-51 -3.7981711228472 7.73867930185606e-74 mirMAP -0.496333797561284 4.78412337852023e-32 NA NA NA hsa-miR-182-5p SCN4B 2.36408084103818 2.60011457600281e-72 -2.97001073145817 8.79751950234415e-72 mirMAP -0.480029380345412 1.22813139135357e-30 NA NA NA hsa-miR-429 SCN4B 2.84108892259147 3.88520896426515e-64 -2.97001073145817 8.79751950234415e-72 miRNATAP -0.487407847560577 1.50388662304222e-51 NA NA NA hsa-miR-96-5p SCN4B 3.24596558166606 1.92296159041707e-98 -2.97001073145817 8.79751950234415e-72 mirMAP -0.518301804112021 1.00707239563883e-53 NA NA NA hsa-miR-200b-3p SCN5A 2.11744072703209 1.66710572104191e-43 -2.93221816182415 3.66462165195964e-47 TargetScan -0.336770374015752 8.44594615745251e-14 NA NA NA hsa-miR-200c-3p SCN5A 2.07038651806183 6.84613386286599e-51 -2.93221816182415 3.66462165195964e-47 miRNATAP -0.404999469957045 2.63224293572836e-16 NA NA NA hsa-miR-429 SCN5A 2.84108892259147 3.88520896426515e-64 -2.93221816182415 3.66462165195964e-47 miRNATAP -0.369452764957324 2.2658772351993e-20 NA NA NA hsa-miR-141-3p SCN7A 2.99777540204168 1.26370498493024e-78 -3.29515354020856 9.67337839110962e-28 TargetScan -0.735813563614467 8.83134502916712e-37 NA NA NA hsa-miR-200b-3p SCN8A 2.11744072703209 1.66710572104191e-43 -0.61871917362853 0.00211208282168513 MirTarget;TargetScan -0.115241654201241 0.00707728700154836 NA NA NA hsa-miR-429 SCN8A 2.84108892259147 3.88520896426515e-64 -0.61871917362853 0.00211208282168513 MirTarget;miRanda -0.125759000815854 0.000985145887832867 NA NA NA hsa-miR-141-3p SCN9A 2.99777540204168 1.26370498493024e-78 -2.67160575217133 3.66657527528624e-58 TargetScan -0.568609440263294 1.59170297499728e-71 NA NA NA hsa-miR-182-5p SCN9A 2.36408084103818 2.60011457600281e-72 -2.67160575217133 3.66657527528624e-58 mirMAP;miRNATAP -0.538944872201914 3.01214195235408e-40 NA NA NA hsa-miR-429 SCN9A 2.84108892259147 3.88520896426515e-64 -2.67160575217133 3.66657527528624e-58 miRanda;miRNATAP -0.481230199533603 8.29720608781309e-52 NA NA NA hsa-miR-96-5p SCN9A 3.24596558166606 1.92296159041707e-98 -2.67160575217133 3.66657527528624e-58 TargetScan;miRNATAP -0.514919919726624 9.46882440759304e-55 NA NA NA hsa-miR-10b-5p SDC1 -2.10996264627796 7.36811595736367e-72 2.40368042487631 4.37964429167287e-49 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.400756246291133 9.49557290109306e-19 22573479 In breast cancer overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1 a predicted target of the oncomiR miR-10b correlates with poor clinical outcome; To investigate the potential functional relationship of miR-10b and syndecan-1 MDA-MB-231 and MCF-7 breast cancer cells were transiently transfected with pre-miR-10b syndecan-1 siRNA or control reagents respectively; miR-10b overexpression induced post-transcriptional downregulation of syndecan-1 as demonstrated by quantitative real-time PCR qPCR flow cytometry and 3'UTR luciferase assays resulting in increased cancer cell migration and matrigel invasiveness; We conclude that syndecan-1 is a novel target of the oncomiR miR-10b cell migration breast cancer hsa-miR-486-5p SDC1 -3.87258704301474 1.22658629378451e-80 2.40368042487631 4.37964429167287e-49 miRanda -0.368421700706251 6.65137792846804e-50 NA NA NA hsa-miR-141-3p SDC2 2.99777540204168 1.26370498493024e-78 -0.778768700466077 1.75535307602845e-09 MirTarget;TargetScan -0.232334358466436 7.51714963303503e-21 NA NA NA hsa-miR-182-5p SDC2 2.36408084103818 2.60011457600281e-72 -0.778768700466077 1.75535307602845e-09 miRNATAP -0.27436560707356 2.14380769627039e-19 NA NA NA hsa-miR-200a-3p SDC2 2.55218480823434 2.96135446816238e-51 -0.778768700466077 1.75535307602845e-09 MirTarget -0.21141258163233 4.94594068047527e-18 NA NA NA hsa-miR-200b-3p SDC2 2.11744072703209 1.66710572104191e-43 -0.778768700466077 1.75535307602845e-09 TargetScan -0.226356595204484 8.98383680168078e-17 NA NA NA hsa-miR-200c-3p SDC2 2.07038651806183 6.84613386286599e-51 -0.778768700466077 1.75535307602845e-09 miRNATAP -0.285794830279355 6.91675858487873e-22 NA NA NA hsa-miR-375 SDC2 2.09893673049766 1.68351780396203e-16 -0.778768700466077 1.75535307602845e-09 miRanda -0.135574098406759 1.24555079165715e-15 NA NA NA hsa-miR-429 SDC2 2.84108892259147 3.88520896426515e-64 -0.778768700466077 1.75535307602845e-09 PITA;miRanda;miRNATAP -0.173920040486896 1.09489329809862e-12 NA NA NA hsa-miR-96-5p SDC2 3.24596558166606 1.92296159041707e-98 -0.778768700466077 1.75535307602845e-09 MirTarget;TargetScan;miRNATAP -0.20885282217362 1.87430852279644e-16 NA NA NA hsa-miR-224-5p SDC4 -2.22249420723892 1.07787949391113e-18 0.338332926801772 0.000350382576050452 MirTarget -0.100112838718792 6.96775647086021e-16 NA NA NA hsa-miR-335-5p SDF2L1 -2.61355235628987 2.6462884165886e-51 1.64547098198535 2.23576891552711e-43 miRNAWalker2_validate -0.246177962229233 1.41644945776204e-27 NA NA NA hsa-miR-183-5p SDK1 2.95681814393872 1.09965777344285e-92 -1.45784340345531 2.42585694660776e-18 mirMAP -0.214051743900904 1.89907851687473e-09 NA NA NA hsa-miR-141-3p SDK2 2.99777540204168 1.26370498493024e-78 -1.46435315270485 4.01650020293667e-10 mirMAP -0.205731240942938 7.22302381743489e-06 NA NA NA hsa-miR-141-5p SDK2 2.38411349683216 4.56310582620282e-58 -1.46435315270485 4.01650020293667e-10 mirMAP -0.118881468658948 0.0194604777319352 NA NA NA hsa-miR-200a-3p SDK2 2.55218480823434 2.96135446816238e-51 -1.46435315270485 4.01650020293667e-10 mirMAP -0.185757275590572 3.69700258536715e-05 NA NA NA hsa-miR-200b-3p SDK2 2.11744072703209 1.66710572104191e-43 -1.46435315270485 4.01650020293667e-10 TargetScan -0.139164140373925 0.00558333828053964 NA NA NA hsa-miR-200c-3p SDK2 2.07038651806183 6.84613386286599e-51 -1.46435315270485 4.01650020293667e-10 miRNATAP -0.14298077964209 0.0096383002785103 NA NA NA hsa-miR-429 SDK2 2.84108892259147 3.88520896426515e-64 -1.46435315270485 4.01650020293667e-10 miRanda;miRNATAP -0.161500063041255 0.00030947192139034 NA NA NA hsa-miR-335-5p SDR16C5 -2.61355235628987 2.6462884165886e-51 0.829669443748783 0.022381062464082 miRNAWalker2_validate -0.235869058211473 0.000472370606195809 NA NA NA hsa-miR-99a-5p SEC13 -2.25079447371102 1.14086813185885e-54 0.766760505041367 3.43844655110198e-33 miRNAWalker2_validate -0.155122732003643 1.30644988149558e-27 NA NA NA hsa-miR-182-5p SEC14L1 2.36408084103818 2.60011457600281e-72 -0.846318322327092 1.35612166023159e-39 miRNATAP -0.187971510621653 3.36428940235999e-34 NA NA NA hsa-miR-429 SEC14L1 2.84108892259147 3.88520896426515e-64 -0.846318322327092 1.35612166023159e-39 miRNATAP -0.145298805206043 2.81873776372044e-32 NA NA NA hsa-miR-96-5p SEC14L1 3.24596558166606 1.92296159041707e-98 -0.846318322327092 1.35612166023159e-39 miRNATAP -0.161579349631791 8.03955895503462e-37 NA NA NA hsa-miR-21-5p SEC14L5 2.32007501846389 3.08394781855554e-137 -1.61597585641235 2.84815826146403e-17 mirMAP -0.65488986326132 7.81502049229416e-29 NA NA NA hsa-miR-224-5p SEC16A -2.22249420723892 1.07787949391113e-18 0.705401856519326 1.92241123956851e-20 MirTarget -0.118941357270567 7.19055076379025e-33 NA NA NA hsa-miR-429 SEC16B 2.84108892259147 3.88520896426515e-64 -0.971049273716321 4.2626260311213e-15 miRanda -0.14761907492594 4.12703528865075e-10 NA NA NA hsa-miR-21-5p SEC22C 2.32007501846389 3.08394781855554e-137 -0.236793837000936 1.17569240674601e-05 mirMAP -0.137892439272061 8.62760683515707e-17 NA NA NA hsa-miR-200b-3p SEC23A 2.11744072703209 1.66710572104191e-43 -0.589349034697416 5.8665748547607e-12 MirTarget;TargetScan -0.236686644918355 7.98169651428987e-42 NA NA NA hsa-miR-200c-3p SEC23A 2.07038651806183 6.84613386286599e-51 -0.589349034697416 5.8665748547607e-12 MirTarget;miRNATAP -0.26275671311765 1.09889084915032e-42 21593139 A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c prostate cancer hsa-miR-429 SEC23A 2.84108892259147 3.88520896426515e-64 -0.589349034697416 5.8665748547607e-12 MirTarget;PITA;miRanda;miRNATAP -0.186136757461251 4.91859078278661e-32 NA NA NA hsa-miR-139-5p SEC24D -3.25846663863766 2.62018989415003e-112 0.686775136417508 4.04907675359352e-14 miRanda -0.129391858406205 5.39125560075522e-12 NA NA NA hsa-miR-21-5p SEC62 2.32007501846389 3.08394781855554e-137 -0.312290891804568 3.86333659992841e-07 mirMAP -0.172609777894466 5.03430786796368e-20 NA NA NA hsa-miR-141-3p SECISBP2L 2.99777540204168 1.26370498493024e-78 -0.969077352009328 5.10594248247564e-24 MirTarget -0.140825618191598 9.41420798004517e-14 NA NA NA hsa-miR-200a-3p SECISBP2L 2.55218480823434 2.96135446816238e-51 -0.969077352009328 5.10594248247564e-24 MirTarget -0.119292496904454 1.51131405229961e-10 NA NA NA hsa-miR-200b-3p SECISBP2L 2.11744072703209 1.66710572104191e-43 -0.969077352009328 5.10594248247564e-24 TargetScan -0.129011002253049 4.87882265619091e-10 NA NA NA hsa-miR-200c-3p SECISBP2L 2.07038651806183 6.84613386286599e-51 -0.969077352009328 5.10594248247564e-24 miRNATAP -0.13748818928854 1.67393652551634e-09 NA NA NA hsa-miR-429 SECISBP2L 2.84108892259147 3.88520896426515e-64 -0.969077352009328 5.10594248247564e-24 miRanda;miRNATAP -0.143929802759749 5.0288057702335e-15 NA NA NA hsa-miR-141-5p SELE 2.38411349683216 4.56310582620282e-58 -1.18468266204269 1.82039473351418e-07 MirTarget -0.237122487468952 1.24392311360703e-06 NA NA NA hsa-miR-429 SELE 2.84108892259147 3.88520896426515e-64 -1.18468266204269 1.82039473351418e-07 miRanda -0.24212242180011 1.83356887786726e-08 NA NA NA hsa-miR-141-5p SEMA3C 2.38411349683216 4.56310582620282e-58 -1.35009172416276 8.68199868856107e-17 MirTarget -0.155989676502547 1.05580785734135e-05 NA NA NA hsa-miR-429 SEMA3D 2.84108892259147 3.88520896426515e-64 -3.16212031632672 6.11103983092798e-45 miRNATAP -0.516154151851582 1.03594920857854e-32 NA NA NA hsa-miR-200a-5p SEMA3E 2.58844508672328 1.79650654234569e-56 -1.79999771156859 1.67219077463382e-10 MirTarget -0.16524802820672 0.00297861623335339 NA NA NA hsa-miR-21-5p SEMA5A 2.32007501846389 3.08394781855554e-137 -1.71262315110065 2.1761661277251e-29 miRNAWalker2_validate -0.339179931026802 2.91371817319389e-12 NA NA NA hsa-miR-429 SEMA5A 2.84108892259147 3.88520896426515e-64 -1.71262315110065 2.1761661277251e-29 miRNATAP -0.310015822308791 9.68030940012383e-27 NA NA NA hsa-miR-96-5p SEMA5A 3.24596558166606 1.92296159041707e-98 -1.71262315110065 2.1761661277251e-29 TargetScan -0.33535979385832 9.70133738731201e-29 NA NA NA hsa-miR-141-3p SEMA6A 2.99777540204168 1.26370498493024e-78 -1.93003615875352 3.37145321593363e-36 MirTarget;TargetScan;miRNATAP -0.295017142668584 3.49342225673855e-22 20420713 The regulation of SEMA6A by miR-141 was verified by a transfection assay kidney renal cell cancer hsa-miR-200a-3p SEMA6A 2.55218480823434 2.96135446816238e-51 -1.93003615875352 3.37145321593363e-36 MirTarget;miRNATAP -0.236193356813241 4.9290635740973e-15 NA NA NA hsa-miR-21-3p SEMA6A 2.17476065946878 5.15299442583591e-75 -1.93003615875352 3.37145321593363e-36 MirTarget -0.401922578408117 1.90978917642418e-22 NA NA NA hsa-miR-429 SEMA6A 2.84108892259147 3.88520896426515e-64 -1.93003615875352 3.37145321593363e-36 miRNATAP -0.257292183135927 6.74008392956309e-18 NA NA NA hsa-miR-96-5p SEMA6A 3.24596558166606 1.92296159041707e-98 -1.93003615875352 3.37145321593363e-36 TargetScan;miRNATAP -0.32115703081542 2.24079458151648e-25 NA NA NA hsa-miR-183-5p SEMA6D 2.95681814393872 1.09965777344285e-92 -2.4984078728242 1.82880787308589e-46 miRNATAP -0.458952234828329 1.37383004116251e-34 NA NA NA hsa-miR-200b-3p SEMA6D 2.11744072703209 1.66710572104191e-43 -2.4984078728242 1.82880787308589e-46 TargetScan -0.341880354897196 5.97236394597264e-19 NA NA NA hsa-miR-200c-3p SEMA6D 2.07038651806183 6.84613386286599e-51 -2.4984078728242 1.82880787308589e-46 miRNATAP -0.470218612178688 1.67032308177785e-29 NA NA NA hsa-miR-429 SEMA6D 2.84108892259147 3.88520896426515e-64 -2.4984078728242 1.82880787308589e-46 PITA;miRanda;miRNATAP -0.387629696843849 2.0098951923677e-30 NA NA NA hsa-miR-140-3p SENP2 -1.25844395244141 5.29222651039892e-33 -0.169364483657246 0.00193921718376543 mirMAP -0.111140304488665 5.70505657181129e-11 NA NA NA hsa-miR-369-3p SENP2 0.0880848299432269 0.48519534195924 -0.169364483657246 0.00193921718376543 mirMAP -0.111437274643639 3.8132936287651e-14 NA NA NA hsa-miR-429 SEPT10 2.84108892259147 3.88520896426515e-64 -1.12117337972445 5.30222334404791e-44 miRanda -0.139612566239335 9.1369551523076e-19 NA NA NA hsa-miR-429 SEPT11 2.84108892259147 3.88520896426515e-64 -0.39136220184827 1.05228164879661e-05 miRanda;miRNATAP -0.149656023417945 1.36382878256409e-19 NA NA NA hsa-miR-96-5p SEPT11 3.24596558166606 1.92296159041707e-98 -0.39136220184827 1.05228164879661e-05 MirTarget;TargetScan;miRNATAP -0.144649444974635 6.54105690641521e-17 NA NA NA hsa-miR-139-5p SEPT3 -3.25846663863766 2.62018989415003e-112 0.851299362800325 2.82552298499929e-05 PITA;miRanda -0.297518099266587 7.61476873056745e-13 NA NA NA hsa-miR-429 SEPT4 2.84108892259147 3.88520896426515e-64 -0.918768149340309 7.74536252142025e-20 miRNATAP -0.160307098869875 6.33894999328333e-17 NA NA NA hsa-miR-21-5p SERAC1 2.32007501846389 3.08394781855554e-137 -0.1762288515488 0.0139627528255168 miRNAWalker2_validate -0.120613392995982 5.44233291790678e-08 NA NA NA hsa-miR-141-3p SERINC1 2.99777540204168 1.26370498493024e-78 -0.865844406740205 3.00220226649236e-27 TargetScan -0.146938409064883 8.17826052881244e-21 NA NA NA hsa-miR-200b-3p SERINC1 2.11744072703209 1.66710572104191e-43 -0.865844406740205 3.00220226649236e-27 MirTarget;TargetScan -0.13406574474583 8.36479476805704e-15 NA NA NA hsa-miR-200c-3p SERINC1 2.07038651806183 6.84613386286599e-51 -0.865844406740205 3.00220226649236e-27 MirTarget;miRNATAP -0.154630523331077 3.45526894382926e-16 NA NA NA hsa-miR-429 SERINC1 2.84108892259147 3.88520896426515e-64 -0.865844406740205 3.00220226649236e-27 MirTarget;miRanda;miRNATAP -0.144854605957283 2.72249719153519e-21 NA NA NA hsa-miR-335-5p SERINC2 -2.61355235628987 2.6462884165886e-51 1.67568921246841 6.9964180560446e-39 miRNAWalker2_validate -0.216245652653479 1.23885768888514e-18 NA NA NA hsa-miR-96-5p SERINC5 3.24596558166606 1.92296159041707e-98 -0.707062598763725 0.000263760108319229 TargetScan -0.183459576633898 1.63357732489875e-06 NA NA NA hsa-miR-335-5p SERPINA1 -2.61355235628987 2.6462884165886e-51 0.396626436447673 0.0640799863509273 miRNAWalker2_validate -0.110638857114166 0.00544821384087872 NA NA NA hsa-miR-182-5p SERPINB2 2.36408084103818 2.60011457600281e-72 -1.0102951555165 0.00201212997963092 MirTarget -0.426776106407512 3.82165057841532e-08 NA NA NA hsa-miR-96-5p SERPINB2 3.24596558166606 1.92296159041707e-98 -1.0102951555165 0.00201212997963092 miRNATAP -0.288633476850508 7.87423251755574e-06 NA NA NA hsa-miR-21-5p SERPINI1 2.32007501846389 3.08394781855554e-137 -0.430852960122019 0.00919576442229265 miRNAWalker2_validate -0.267869656654958 1.79799152826543e-07 22464652 MicroRNA 21 inhibits Serpini1 a gene with novel tumour suppressive effects in gastric cancer; Molecular techniques include microRNA microarrays cDNA microarrays qRT-PCR for miR and mRNA expression transfection of MKN28 with miR-21 inhibitor or Serpini1 followed by Western blotting cell cycle analysis by flow cytometry and luciferase reporter assay; This search identified Serpini1 as a putative miR-21 target; Luciferase assays demonstrated direct interaction between miR-21 and Serpini1 3'UTR miR-21 and Serpini1 expression levels were inversely correlated in a subgroup of gastric cancers suggesting a regulatory mechanism that included both of these molecules; Taken together these data suggest that in a subgroup of gastric cancers miR-21 is upregulated inducing downregulation of Serpini1 which in turn releases the G1-S transition checkpoint with the end result being increased tumour growth gastric cancer hsa-miR-429 SERPINI1 2.84108892259147 3.88520896426515e-64 -0.430852960122019 0.00919576442229265 miRanda;miRNATAP -0.124032151920872 7.3941652873906e-05 NA NA NA hsa-miR-183-5p SESN1 2.95681814393872 1.09965777344285e-92 -0.952506930201764 9.2781623761265e-26 MirTarget -0.161098381239242 9.03230688259721e-17 NA NA NA hsa-miR-200b-3p SESN1 2.11744072703209 1.66710572104191e-43 -0.952506930201764 9.2781623761265e-26 MirTarget;TargetScan -0.15680863005288 9.5895183779347e-16 NA NA NA hsa-miR-200c-3p SESN1 2.07038651806183 6.84613386286599e-51 -0.952506930201764 9.2781623761265e-26 MirTarget;miRNATAP -0.201332360113161 3.52294439599536e-21 24791940 We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2 GAPB/Nrf2 and SESN1 in ways that inhibits DNA double-strand breaks repair increase levels of reactive oxygen species and upregulate p21 drug resistance lung cancer hsa-miR-21-5p SESN1 2.32007501846389 3.08394781855554e-137 -0.952506930201764 9.2781623761265e-26 miRNAWalker2_validate -0.28257542976425 2.54012028934313e-23 NA NA NA hsa-miR-429 SESN1 2.84108892259147 3.88520896426515e-64 -0.952506930201764 9.2781623761265e-26 MirTarget;PITA;miRanda;miRNATAP -0.171716505184115 2.54156813302447e-23 NA NA NA hsa-miR-182-5p SESN3 2.36408084103818 2.60011457600281e-72 -1.56636935086919 2.7817870595808e-14 mirMAP -0.294879951435881 2.49105093025748e-09 NA NA NA hsa-miR-200a-5p SESN3 2.58844508672328 1.79650654234569e-56 -1.56636935086919 2.7817870595808e-14 mirMAP -0.123238417965444 0.00255673729040383 NA NA NA hsa-miR-200b-3p SESN3 2.11744072703209 1.66710572104191e-43 -1.56636935086919 2.7817870595808e-14 MirTarget;TargetScan -0.212089757301576 1.5907832953698e-06 NA NA NA hsa-miR-200c-3p SESN3 2.07038651806183 6.84613386286599e-51 -1.56636935086919 2.7817870595808e-14 MirTarget -0.280493924637921 7.03401362281759e-09 NA NA NA hsa-miR-429 SESN3 2.84108892259147 3.88520896426515e-64 -1.56636935086919 2.7817870595808e-14 MirTarget -0.21526281577192 4.59928855164874e-08 NA NA NA hsa-miR-96-5p SESN3 3.24596558166606 1.92296159041707e-98 -1.56636935086919 2.7817870595808e-14 MirTarget;TargetScan -0.289391385796295 1.42047141837302e-12 NA NA NA hsa-miR-21-5p SESTD1 2.32007501846389 3.08394781855554e-137 -0.827342931728161 2.16755903388799e-18 miRNAWalker2_validate;mirMAP -0.305477983994508 1.39045415565243e-25 NA NA NA hsa-miR-429 SESTD1 2.84108892259147 3.88520896426515e-64 -0.827342931728161 2.16755903388799e-18 miRNATAP -0.109307489012722 1.67579807345603e-09 NA NA NA hsa-miR-141-3p SETBP1 2.99777540204168 1.26370498493024e-78 -1.18671410483241 6.28416400335858e-18 miRNATAP -0.200964641932276 8.31017491919566e-14 NA NA NA hsa-miR-200a-3p SETBP1 2.55218480823434 2.96135446816238e-51 -1.18671410483241 6.28416400335858e-18 miRNATAP -0.137920302985048 2.24359593235803e-07 NA NA NA hsa-miR-429 SETBP1 2.84108892259147 3.88520896426515e-64 -1.18671410483241 6.28416400335858e-18 miRanda -0.196583412294006 6.61330156493316e-14 NA NA NA hsa-miR-96-5p SETBP1 3.24596558166606 1.92296159041707e-98 -1.18671410483241 6.28416400335858e-18 mirMAP -0.143936858049947 1.85767594054796e-07 NA NA NA hsa-miR-182-5p SETD7 2.36408084103818 2.60011457600281e-72 -1.05533462896746 5.56168604809659e-30 MirTarget;miRNATAP -0.120384309836651 1.26758305087528e-07 NA NA NA hsa-miR-200b-3p SETD7 2.11744072703209 1.66710572104191e-43 -1.05533462896746 5.56168604809659e-30 TargetScan -0.193672197594332 2.09038302499674e-22 NA NA NA hsa-miR-200c-3p SETD7 2.07038651806183 6.84613386286599e-51 -1.05533462896746 5.56168604809659e-30 miRNATAP -0.225849798047109 3.61659692419147e-25 NA NA NA hsa-miR-429 SETD7 2.84108892259147 3.88520896426515e-64 -1.05533462896746 5.56168604809659e-30 miRNATAP -0.187334814914865 2.93367558608303e-26 NA NA NA hsa-miR-96-5p SETD7 3.24596558166606 1.92296159041707e-98 -1.05533462896746 5.56168604809659e-30 TargetScan;miRNATAP -0.153889749371132 1.7843926550794e-16 NA NA NA hsa-miR-429 SETX 2.84108892259147 3.88520896426515e-64 -0.529021109108933 6.61363530360323e-16 miRanda -0.109474371946649 7.71932297139492e-19 NA NA NA hsa-miR-200b-3p SFMBT2 2.11744072703209 1.66710572104191e-43 -0.841672830700126 6.22220480584314e-07 mirMAP -0.152183088144857 2.29963196691709e-05 NA NA NA hsa-miR-200c-3p SFMBT2 2.07038651806183 6.84613386286599e-51 -0.841672830700126 6.22220480584314e-07 mirMAP -0.116173455070134 0.00337968975690968 NA NA NA hsa-miR-429 SFMBT2 2.84108892259147 3.88520896426515e-64 -0.841672830700126 6.22220480584314e-07 mirMAP -0.161317281713237 4.73761675979713e-07 NA NA NA hsa-miR-139-5p SFPQ -3.25846663863766 2.62018989415003e-112 0.612974005792418 1.21173953487845e-46 miRanda -0.142826980108947 5.47456545687954e-62 NA NA NA hsa-miR-1301-3p SFRP1 1.80754972811286 2.96809840886499e-36 -4.57542964080819 4.43759637848337e-44 MirTarget -0.627568666111828 8.02299635565225e-16 NA NA NA hsa-miR-16-1-3p SFRP1 1.30142784811196 2.53343713753744e-29 -4.57542964080819 4.43759637848337e-44 MirTarget -0.711103027959144 8.81693153322732e-12 NA NA NA hsa-miR-182-5p SFRP1 2.36408084103818 2.60011457600281e-72 -4.57542964080819 4.43759637848337e-44 mirMAP -0.967266087949178 4.26592739938163e-34 NA NA NA hsa-miR-429 SFRP1 2.84108892259147 3.88520896426515e-64 -4.57542964080819 4.43759637848337e-44 miRNATAP -0.482539995817486 1.02848505471575e-13 NA NA NA hsa-miR-484 SFRP1 0.349444060004737 0.00154491249625173 -4.57542964080819 4.43759637848337e-44 MirTarget -0.736652971526416 5.14194951874832e-12 NA NA NA hsa-miR-625-5p SFRP1 0.728939236913178 5.97591217674307e-08 -4.57542964080819 4.43759637848337e-44 MirTarget -0.628996046116407 2.3830320131247e-12 NA NA NA hsa-miR-7-1-3p SFRP1 0.686579567507582 1.20731554448806e-07 -4.57542964080819 4.43759637848337e-44 MirTarget;mirMAP -0.630150561051086 2.75485010272039e-12 NA NA NA hsa-miR-96-5p SFRP1 3.24596558166606 1.92296159041707e-98 -4.57542964080819 4.43759637848337e-44 mirMAP -0.844516363711542 6.21667681893678e-38 NA NA NA hsa-let-7a-3p SFRP2 0.466622567891891 3.70886257943079e-07 0.628681716609233 0.00130373866009022 miRNATAP -0.332636167789599 4.93713573566124e-06 NA NA NA hsa-miR-29a-3p SFRP2 -0.699539666833076 1.13935003139957e-13 0.628681716609233 0.00130373866009022 miRNAWalker2_validate;miRTarBase -0.155587096466859 0.0276230069718623 NA NA NA hsa-miR-455-5p SFRP2 0.284641224662773 0.0357572339594277 0.628681716609233 0.00130373866009022 miRanda -0.2181929694718 1.02630459230339e-05 NA NA NA hsa-miR-582-5p SFRP2 0.201134299470983 0.149482495292227 0.628681716609233 0.00130373866009022 miRNATAP -0.11158761801029 0.0221651196488598 NA NA NA hsa-miR-590-3p SFRP2 1.27438512890514 1.03164723481469e-23 0.628681716609233 0.00130373866009022 miRanda -0.307596222223987 8.75286794331675e-09 NA NA NA hsa-miR-3607-3p SFRP4 0.00697875745616461 0.972073275173643 -0.600105446413612 0.00305552026524159 MirTarget -0.118981576120521 0.000643377135339091 NA NA NA hsa-miR-429 SFRP4 2.84108892259147 3.88520896426515e-64 -0.600105446413612 0.00305552026524159 miRanda -0.313049201490686 1.13859376562001e-16 NA NA NA hsa-miR-532-5p SFRP4 0.0386976222860582 0.682018574136515 -0.600105446413612 0.00305552026524159 MirTarget -0.348327615827745 2.35831438297707e-06 NA NA NA hsa-miR-375 SFT2D2 2.09893673049766 1.68351780396203e-16 0.18179745523463 0.0592682623590624 miRNAWalker2_validate -0.112846977384227 1.10111461408231e-19 NA NA NA hsa-miR-182-5p SGCB 2.36408084103818 2.60011457600281e-72 -1.13558235438512 3.11926576951198e-34 mirMAP -0.213074481062613 3.87855822890513e-21 NA NA NA hsa-miR-21-5p SGCB 2.32007501846389 3.08394781855554e-137 -1.13558235438512 3.11926576951198e-34 miRNAWalker2_validate -0.380361072104493 9.14013099981249e-40 NA NA NA hsa-miR-429 SGCB 2.84108892259147 3.88520896426515e-64 -1.13558235438512 3.11926576951198e-34 miRanda;miRNATAP -0.166562587898924 1.84530161414e-20 NA NA NA hsa-miR-200b-3p SGCD 2.11744072703209 1.66710572104191e-43 -1.03490447383629 2.87494382883947e-10 mirMAP -0.34826142665604 2.52588558152801e-24 NA NA NA hsa-miR-200c-3p SGCD 2.07038651806183 6.84613386286599e-51 -1.03490447383629 2.87494382883947e-10 mirMAP -0.428620938419301 1.60025150088249e-30 NA NA NA hsa-miR-21-3p SGCD 2.17476065946878 5.15299442583591e-75 -1.03490447383629 2.87494382883947e-10 mirMAP -0.124901327450751 0.00423892545819726 NA NA NA hsa-miR-429 SGCD 2.84108892259147 3.88520896426515e-64 -1.03490447383629 2.87494382883947e-10 mirMAP -0.318206488597772 1.84039361156199e-25 NA NA NA hsa-miR-200b-3p SGCE 2.11744072703209 1.66710572104191e-43 -1.49325860771838 2.1221860637679e-26 TargetScan -0.244300370365085 6.66444856326283e-16 NA NA NA hsa-miR-429 SGCE 2.84108892259147 3.88520896426515e-64 -1.49325860771838 2.1221860637679e-26 PITA;miRanda -0.224806258834833 7.87779422444489e-17 NA NA NA hsa-miR-21-5p SGK3 2.32007501846389 3.08394781855554e-137 -0.122969610682381 0.394389715112252 miRNAWalker2_validate -0.123722166946783 0.00594242169029888 NA NA NA hsa-miR-182-5p SGMS2 2.36408084103818 2.60011457600281e-72 -0.807789774355594 4.88817522977496e-09 MirTarget;miRNATAP -0.249548388481804 2.3644745238478e-14 NA NA NA hsa-miR-96-5p SGMS2 3.24596558166606 1.92296159041707e-98 -0.807789774355594 4.88817522977496e-09 TargetScan -0.222438602091129 2.06701000490017e-16 NA NA NA hsa-miR-200b-3p SGPP1 2.11744072703209 1.66710572104191e-43 -0.63642359336911 7.43044452572603e-09 MirTarget -0.170604440401858 2.09572553299774e-13 NA NA NA hsa-miR-200c-3p SGPP1 2.07038651806183 6.84613386286599e-51 -0.63642359336911 7.43044452572603e-09 MirTarget -0.174220948989911 1.02095538658238e-11 NA NA NA hsa-miR-429 SGPP1 2.84108892259147 3.88520896426515e-64 -0.63642359336911 7.43044452572603e-09 MirTarget;miRanda -0.149335785110452 6.34168252232746e-13 NA NA NA hsa-miR-429 SGSM1 2.84108892259147 3.88520896426515e-64 -1.49611607777144 1.28769127035401e-16 mirMAP -0.150906780930683 1.45034274739832e-05 NA NA NA hsa-miR-21-5p SGTB 2.32007501846389 3.08394781855554e-137 -0.640414986045701 1.46919614901498e-18 mirMAP -0.144408981565387 3.14985679730937e-10 NA NA NA hsa-miR-429 SGTB 2.84108892259147 3.88520896426515e-64 -0.640414986045701 1.46919614901498e-18 miRanda -0.124060080025628 2.20743315277089e-19 NA NA NA hsa-miR-141-3p SH2B3 2.99777540204168 1.26370498493024e-78 -0.499438088124607 1.87467089235755e-11 MirTarget -0.166743496313069 1.93686167146146e-32 NA NA NA hsa-miR-200a-3p SH2B3 2.55218480823434 2.96135446816238e-51 -0.499438088124607 1.87467089235755e-11 MirTarget -0.153246443865064 2.20024168845711e-28 NA NA NA hsa-miR-429 SH2B3 2.84108892259147 3.88520896426515e-64 -0.499438088124607 1.87467089235755e-11 miRNATAP -0.15230395654988 2.01319043618893e-28 NA NA NA hsa-miR-182-5p SH2D1A 2.36408084103818 2.60011457600281e-72 0.161407085200837 0.460950916464362 MirTarget;miRNATAP -0.194030829188213 0.000192975725720925 NA NA NA hsa-miR-96-5p SH2D1A 3.24596558166606 1.92296159041707e-98 0.161407085200837 0.460950916464362 miRNATAP -0.17859239932629 3.48060879568677e-05 NA NA NA hsa-miR-429 SH2D1B 2.84108892259147 3.88520896426515e-64 -1.32904134561359 1.80952386333017e-15 miRanda -0.208520133376284 6.18227136446046e-11 NA NA NA hsa-miR-335-5p SH2D3A -2.61355235628987 2.6462884165886e-51 1.01111700163415 2.52283390807173e-17 miRNAWalker2_validate -0.174126775688854 5.46441937598391e-15 NA NA NA hsa-miR-21-5p SH3BGRL2 2.32007501846389 3.08394781855554e-137 -2.29494540930947 1.42986023431337e-66 mirMAP -0.589580081826542 4.07541127538102e-43 NA NA NA hsa-miR-429 SH3BGRL2 2.84108892259147 3.88520896426515e-64 -2.29494540930947 1.42986023431337e-66 miRanda;miRNATAP -0.293450404645081 1.96348399064529e-28 NA NA NA hsa-miR-145-5p SH3BP1 -2.62703571936687 7.64402900188551e-88 1.05052173414921 7.27611902114297e-26 MirTarget -0.225525243715051 4.36224673034849e-22 NA NA NA hsa-miR-335-5p SH3BP1 -2.61355235628987 2.6462884165886e-51 1.05052173414921 7.27611902114297e-26 miRNAWalker2_validate -0.1494390495276 2.09834692994755e-15 NA NA NA hsa-miR-429 SH3BP5 2.84108892259147 3.88520896426515e-64 -1.03710428776296 2.536245368188e-34 miRanda -0.149485472508183 7.75946497145142e-20 NA NA NA hsa-miR-96-5p SH3BP5 3.24596558166606 1.92296159041707e-98 -1.03710428776296 2.536245368188e-34 MirTarget;TargetScan;miRNATAP -0.194206409936622 1.17321666642137e-30 NA NA NA hsa-miR-183-5p SH3D19 2.95681814393872 1.09965777344285e-92 -2.02411926896903 2.64584695193641e-89 miRNAWalker2_validate;MirTarget -0.34423816558612 8.35841247025044e-54 NA NA NA hsa-miR-429 SH3D19 2.84108892259147 3.88520896426515e-64 -2.02411926896903 2.64584695193641e-89 miRNATAP -0.338709355475664 3.97661520930169e-66 NA NA NA hsa-miR-429 SH3GL2 2.84108892259147 3.88520896426515e-64 -0.185011358610066 0.485371047150377 miRNATAP -0.125678868088545 0.0123451950545172 NA NA NA hsa-miR-375 SH3GL3 2.09893673049766 1.68351780396203e-16 -0.777875637175819 0.00225496391436024 miRanda -0.235975723124802 1.25850187508117e-12 NA NA NA hsa-miR-96-5p SH3KBP1 3.24596558166606 1.92296159041707e-98 -0.731189495588003 3.71923505778463e-15 MirTarget;TargetScan -0.205810756428685 3.60530755015875e-30 NA NA NA hsa-miR-200b-3p SH3PXD2A 2.11744072703209 1.66710572104191e-43 -0.038658231698439 0.664094392746129 TargetScan -0.106571656091514 1.23508204056981e-08 NA NA NA hsa-miR-200c-3p SH3PXD2A 2.07038651806183 6.84613386286599e-51 -0.038658231698439 0.664094392746129 miRNATAP -0.127105807825875 6.12223479557215e-10 NA NA NA hsa-miR-182-5p SH3PXD2B 2.36408084103818 2.60011457600281e-72 -0.0918386938074187 0.323272517454298 miRNATAP -0.127565377343084 6.2478767330807e-09 NA NA NA hsa-miR-200a-3p SH3PXD2B 2.55218480823434 2.96135446816238e-51 -0.0918386938074187 0.323272517454298 mirMAP -0.101771780917378 6.99474559400164e-09 NA NA NA hsa-miR-96-5p SH3PXD2B 3.24596558166606 1.92296159041707e-98 -0.0918386938074187 0.323272517454298 TargetScan;miRNATAP -0.112238783689941 6.88507172396699e-10 NA NA NA hsa-miR-429 SH3RF2 2.84108892259147 3.88520896426515e-64 -2.10632422116193 1.61519082148695e-22 miRanda -0.243644971353763 4.98638685342252e-09 NA NA NA hsa-miR-96-5p SH3RF2 3.24596558166606 1.92296159041707e-98 -2.10632422116193 1.61519082148695e-22 TargetScan -0.31167421008442 5.86160238093446e-13 NA NA NA hsa-miR-182-5p SH3RF3 2.36408084103818 2.60011457600281e-72 -0.799062132372461 2.74467513168241e-14 MirTarget -0.284974224952005 2.63134937548426e-31 NA NA NA hsa-miR-335-5p SHANK1 -2.61355235628987 2.6462884165886e-51 0.840213438854124 9.75084574678448e-06 miRNAWalker2_validate -0.159363569923544 6.50386802893753e-06 NA NA NA hsa-miR-224-5p SHANK2 -2.22249420723892 1.07787949391113e-18 0.177001714184462 0.2071677875336 mirMAP -0.107562648607512 6.2253289306017e-09 NA NA NA hsa-miR-452-5p SHANK2 -2.48486455572568 1.24430987974325e-33 0.177001714184462 0.2071677875336 mirMAP -0.15121502961319 8.86101838000207e-12 NA NA NA hsa-miR-375 SHANK3 2.09893673049766 1.68351780396203e-16 -1.33183457706851 3.20517661766363e-41 miRanda -0.124834500619257 1.5030788773527e-20 NA NA NA hsa-miR-21-3p SHC3 2.17476065946878 5.15299442583591e-75 -0.964249961362021 6.05525618490845e-10 MirTarget -0.152288264960436 0.000232456177581898 NA NA NA hsa-miR-182-5p SHC4 2.36408084103818 2.60011457600281e-72 -1.36431335418988 1.20803075809528e-06 MirTarget;miRNATAP -0.455690420006772 7.96697878633079e-12 NA NA NA hsa-miR-96-5p SHC4 3.24596558166606 1.92296159041707e-98 -1.36431335418988 1.20803075809528e-06 TargetScan;miRNATAP -0.301827532688072 5.57748009287207e-08 NA NA NA hsa-miR-141-3p SHE 2.99777540204168 1.26370498493024e-78 -2.33195369157373 5.84599306122113e-72 mirMAP -0.486915548811075 2.44790653441642e-85 NA NA NA hsa-miR-141-5p SHE 2.38411349683216 4.56310582620282e-58 -2.33195369157373 5.84599306122113e-72 mirMAP -0.426054679397306 1.21660805472833e-49 NA NA NA hsa-miR-200a-3p SHE 2.55218480823434 2.96135446816238e-51 -2.33195369157373 5.84599306122113e-72 mirMAP -0.398343171433042 1.13265061497131e-55 NA NA NA hsa-miR-200b-3p SHE 2.11744072703209 1.66710572104191e-43 -2.33195369157373 5.84599306122113e-72 mirMAP -0.408001908358227 2.12715262180061e-46 NA NA NA hsa-miR-200c-3p SHE 2.07038651806183 6.84613386286599e-51 -2.33195369157373 5.84599306122113e-72 mirMAP -0.497551185952991 2.21664107166307e-58 NA NA NA hsa-miR-429 SHE 2.84108892259147 3.88520896426515e-64 -2.33195369157373 5.84599306122113e-72 miRanda;mirMAP -0.408874211909371 5.55181916063278e-60 NA NA NA hsa-miR-429 SHISA2 2.84108892259147 3.88520896426515e-64 -0.0881092399519519 0.754073621031887 miRanda -0.109987125224245 0.0390626982135486 NA NA NA hsa-miR-200a-5p SHISA6 2.58844508672328 1.79650654234569e-56 -1.68226082206879 2.45685318014832e-13 miRNATAP -0.28720210706331 1.95196574702801e-10 NA NA NA hsa-miR-429 SHISA6 2.84108892259147 3.88520896426515e-64 -1.68226082206879 2.45685318014832e-13 miRanda -0.369645670398648 1.50576937031221e-17 NA NA NA hsa-miR-224-5p SHISA9 -2.22249420723892 1.07787949391113e-18 0.951576190951404 0.00379808291856681 MirTarget -0.156485774336624 0.000347300328186189 NA NA NA hsa-miR-452-5p SHISA9 -2.48486455572568 1.24430987974325e-33 0.951576190951404 0.00379808291856681 mirMAP -0.174415216371001 0.000911859347080672 NA NA NA hsa-miR-375 SHOX2 2.09893673049766 1.68351780396203e-16 -0.717729047322027 6.5727195471221e-09 PITA;miRanda;miRNATAP -0.14931751902148 1.66303863155422e-20 24746361 SHOX2 is a direct miR 375 target and a novel epithelial to mesenchymal transition inducer in breast cancer cells breast cancer hsa-miR-429 SHOX2 2.84108892259147 3.88520896426515e-64 -0.717729047322027 6.5727195471221e-09 miRanda;miRNATAP -0.246957195453251 4.13325130380049e-27 NA NA NA hsa-miR-96-5p SHOX2 3.24596558166606 1.92296159041707e-98 -0.717729047322027 6.5727195471221e-09 TargetScan;miRNATAP -0.244991210639847 1.73826292589705e-24 NA NA NA hsa-miR-21-3p SHPRH 2.17476065946878 5.15299442583591e-75 -1.26386235272984 1.35579422106635e-18 MirTarget -0.183135111407905 1.92721187932987e-06 NA NA NA hsa-miR-429 SHPRH 2.84108892259147 3.88520896426515e-64 -1.26386235272984 1.35579422106635e-18 miRanda -0.160519568239392 5.92791867215886e-09 NA NA NA hsa-miR-145-5p SHROOM3 -2.62703571936687 7.64402900188551e-88 0.488940714880925 0.000112620796190186 mirMAP -0.110021382390292 0.000187719847175075 NA NA NA hsa-miR-511-5p SHROOM3 -2.27545475897362 3.84085514050558e-36 0.488940714880925 0.000112620796190186 MirTarget -0.161974908391736 1.32527296441518e-12 NA NA NA hsa-miR-141-3p SHROOM4 2.99777540204168 1.26370498493024e-78 -1.4723405869569 4.07370031193927e-41 TargetScan;mirMAP -0.321914577096056 5.10763512087704e-53 NA NA NA hsa-miR-141-5p SHROOM4 2.38411349683216 4.56310582620282e-58 -1.4723405869569 4.07370031193927e-41 mirMAP -0.282700247446131 1.93535605341347e-32 NA NA NA hsa-miR-200a-3p SHROOM4 2.55218480823434 2.96135446816238e-51 -1.4723405869569 4.07370031193927e-41 mirMAP -0.266689248398693 8.59079524569429e-37 NA NA NA hsa-miR-200b-3p SHROOM4 2.11744072703209 1.66710572104191e-43 -1.4723405869569 4.07370031193927e-41 TargetScan;mirMAP -0.284732211007227 8.79595118235852e-34 NA NA NA hsa-miR-200c-3p SHROOM4 2.07038651806183 6.84613386286599e-51 -1.4723405869569 4.07370031193927e-41 mirMAP -0.346006755351506 1.07255488368534e-41 NA NA NA hsa-miR-429 SHROOM4 2.84108892259147 3.88520896426515e-64 -1.4723405869569 4.07370031193927e-41 miRanda;mirMAP;miRNATAP -0.276474944891916 2.77423424138085e-40 NA NA NA hsa-miR-15a-5p SIAH1 0.812445324157528 4.50263417099822e-20 -0.165120120542028 0.00588542147742729 miRNATAP -0.119160033954367 1.42207849374965e-07 NA NA NA hsa-miR-141-3p SIDT2 2.99777540204168 1.26370498493024e-78 -0.851193559016696 4.65419283102878e-33 TargetScan -0.171199217283826 1.69081656394692e-35 NA NA NA hsa-miR-183-5p SIDT2 2.95681814393872 1.09965777344285e-92 -0.851193559016696 4.65419283102878e-33 miRNATAP -0.155232330545048 1.15098927970065e-24 NA NA NA hsa-miR-335-5p SIGIRR -2.61355235628987 2.6462884165886e-51 1.20603210103584 2.08603217550485e-24 miRNAWalker2_validate -0.134331573465158 2.1542457954866e-09 NA NA NA hsa-miR-141-3p SIGLEC1 2.99777540204168 1.26370498493024e-78 -0.0595021033403764 0.696119447357449 mirMAP -0.106623293268124 0.000307461298551919 NA NA NA hsa-miR-200a-3p SIGLEC1 2.55218480823434 2.96135446816238e-51 -0.0595021033403764 0.696119447357449 mirMAP -0.100825468497495 0.000506142903565051 NA NA NA hsa-miR-486-5p SIGLEC10 -3.87258704301474 1.22658629378451e-80 0.658953664971289 1.23230469818355e-07 miRanda -0.100822752979934 1.03446143800348e-07 NA NA NA hsa-miR-335-5p SIGLEC5 -2.61355235628987 2.6462884165886e-51 0.807620400202214 5.27381292459028e-09 miRNAWalker2_validate -0.119537931326669 3.68887526622189e-06 NA NA NA hsa-miR-141-3p SIK1 2.99777540204168 1.26370498493024e-78 -0.660834516074939 8.03803537618752e-07 MirTarget;TargetScan;miRNATAP -0.120407310261369 3.92832534879647e-06 27081781 Suppression of SIK1 by miR 141 in human ovarian cancer cell lines and tissues; All three algorithms predicted that miR-141 targets the 3'UTR of SIK1 ovarian cancer hsa-miR-182-5p SIK1 2.36408084103818 2.60011457600281e-72 -0.660834516074939 8.03803537618752e-07 miRNATAP -0.198976697769263 3.99129838232668e-10 NA NA NA hsa-miR-429 SIK1 2.84108892259147 3.88520896426515e-64 -0.660834516074939 8.03803537618752e-07 miRNATAP -0.118252269224713 3.28666986492499e-06 NA NA NA hsa-miR-96-5p SIK1 3.24596558166606 1.92296159041707e-98 -0.660834516074939 8.03803537618752e-07 TargetScan;miRNATAP -0.191585087660408 3.1546362743282e-13 NA NA NA hsa-miR-182-5p SIK2 2.36408084103818 2.60011457600281e-72 -2.29859523998516 3.63982740667992e-106 mirMAP -0.367269671399156 1.40360569387252e-41 NA NA NA hsa-miR-200a-3p SIK2 2.55218480823434 2.96135446816238e-51 -2.29859523998516 3.63982740667992e-106 MirTarget -0.300184866290929 1.69914350725146e-43 NA NA NA hsa-miR-200b-3p SIK2 2.11744072703209 1.66710572104191e-43 -2.29859523998516 3.63982740667992e-106 TargetScan -0.338542850238282 8.04919830600078e-45 NA NA NA hsa-miR-96-5p SIK2 3.24596558166606 1.92296159041707e-98 -2.29859523998516 3.63982740667992e-106 TargetScan;mirMAP -0.346125551374951 6.08284453040503e-55 NA NA NA hsa-miR-183-5p SIK3 2.95681814393872 1.09965777344285e-92 -0.681001325300318 8.40973896430972e-16 miRNATAP -0.128521999204185 7.15324665268704e-13 NA NA NA hsa-miR-141-3p SIM1 2.99777540204168 1.26370498493024e-78 -3.0298739046154 2.66788857367664e-25 MirTarget -0.449250767916397 5.87636851280913e-15 NA NA NA hsa-miR-200a-3p SIM1 2.55218480823434 2.96135446816238e-51 -3.0298739046154 2.66788857367664e-25 MirTarget -0.341583072487637 1.9010074141214e-09 NA NA NA hsa-miR-21-5p SIM1 2.32007501846389 3.08394781855554e-137 -3.0298739046154 2.66788857367664e-25 mirMAP -0.750621803033214 3.71689711035348e-16 NA NA NA hsa-miR-96-5p SIM1 3.24596558166606 1.92296159041707e-98 -3.0298739046154 2.66788857367664e-25 MirTarget -0.485333846107247 9.45278804381957e-17 NA NA NA hsa-miR-200b-3p SIRPA 2.11744072703209 1.66710572104191e-43 -1.34210437000021 8.07228675543371e-43 MirTarget -0.217997017483508 1.20741262880431e-24 NA NA NA hsa-miR-200c-3p SIRPA 2.07038651806183 6.84613386286599e-51 -1.34210437000021 8.07228675543371e-43 MirTarget -0.269951000011422 2.49781797486613e-31 NA NA NA hsa-miR-429 SIRPA 2.84108892259147 3.88520896426515e-64 -1.34210437000021 8.07228675543371e-43 MirTarget;miRanda;miRNATAP -0.192199619993541 4.98740979875358e-24 NA NA NA hsa-miR-429 SIRPB1 2.84108892259147 3.88520896426515e-64 -1.13663411851132 6.3803940411075e-18 miRanda -0.185989281348796 1.36513575413573e-13 NA NA NA hsa-miR-335-5p SIRT7 -2.61355235628987 2.6462884165886e-51 1.08383105862547 2.36777309777559e-35 miRNAWalker2_validate -0.144359701171692 3.55253060455975e-18 NA NA NA hsa-miR-10b-5p SIX4 -2.10996264627796 7.36811595736367e-72 1.40713523170565 1.66102541379513e-29 miRNATAP -0.234688141361746 5.61231837326084e-12 NA NA NA hsa-miR-139-5p SIX4 -3.25846663863766 2.62018989415003e-112 1.40713523170565 1.66102541379513e-29 miRanda -0.274816346346194 1.82596124430678e-26 NA NA NA hsa-miR-10b-5p SKA2 -2.10996264627796 7.36811595736367e-72 0.707113487676799 3.05828295037254e-14 MirTarget -0.186557127761786 5.82108404812222e-14 NA NA NA hsa-miR-511-5p SKA3 -2.27545475897362 3.84085514050558e-36 3.19614484681097 1.51699709515064e-83 MirTarget -0.163971553695523 8.10861284328641e-07 NA NA NA hsa-miR-182-5p SKAP2 2.36408084103818 2.60011457600281e-72 -1.40094392320459 6.79212188545333e-42 miRNATAP -0.266931414550228 2.53131139007191e-26 NA NA NA hsa-miR-429 SKAP2 2.84108892259147 3.88520896426515e-64 -1.40094392320459 6.79212188545333e-42 miRanda -0.262459669392773 7.53118514543224e-41 NA NA NA hsa-miR-21-5p SKI 2.32007501846389 3.08394781855554e-137 -0.728452117640105 6.78846109698789e-33 MirTarget;miRNATAP -0.187847853952807 1.72284744033067e-22 NA NA NA hsa-miR-21-5p SKIV2L2 2.32007501846389 3.08394781855554e-137 -0.173863736689151 0.00278236512532617 mirMAP -0.115753722183293 1.05918585352273e-10 NA NA NA hsa-miR-130a-3p SKP1 -1.15024914519431 6.51290317952496e-19 0.0738382124630679 0.231791018805648 MirTarget -0.139641825685064 4.17514374271046e-19 NA NA NA hsa-miR-130b-3p SKP1 1.38122163823846 1.00932179737836e-26 0.0738382124630679 0.231791018805648 MirTarget -0.106102178127117 1.72601795720608e-11 NA NA NA hsa-miR-222-3p SKP1 -0.429279381480379 0.00103945569781115 0.0738382124630679 0.231791018805648 MirTarget -0.10501825880122 4.51166430229641e-11 NA NA NA hsa-miR-183-5p SLAIN1 2.95681814393872 1.09965777344285e-92 -2.0290956913259 2.56704037099149e-19 MirTarget;miRNATAP -0.367519899685276 1.84303644276683e-14 NA NA NA hsa-miR-375 SLAIN1 2.09893673049766 1.68351780396203e-16 -2.0290956913259 2.56704037099149e-19 miRanda -0.156226540934221 2.53900044786838e-07 NA NA NA hsa-miR-429 SLAIN1 2.84108892259147 3.88520896426515e-64 -2.0290956913259 2.56704037099149e-19 miRanda;miRNATAP -0.235305580802781 6.2868236092218e-08 NA NA NA hsa-miR-96-5p SLAIN1 3.24596558166606 1.92296159041707e-98 -2.0290956913259 2.56704037099149e-19 miRNAWalker2_validate -0.370296953936244 1.5811384201074e-16 NA NA NA hsa-miR-21-5p SLAIN2 2.32007501846389 3.08394781855554e-137 -0.243398220814224 3.55807577292244e-05 miRNAWalker2_validate -0.155076505137744 7.73778851496149e-18 NA NA NA hsa-miR-486-5p SLC12A1 -3.87258704301474 1.22658629378451e-80 -0.247889415814543 0.412678712721866 miRanda -0.116559339350549 0.0112350829227381 NA NA NA hsa-miR-429 SLC12A6 2.84108892259147 3.88520896426515e-64 -1.06836794682769 1.31891162117757e-37 miRanda;miRNATAP -0.1584527399827 7.66121375081935e-23 NA NA NA hsa-miR-96-5p SLC12A6 3.24596558166606 1.92296159041707e-98 -1.06836794682769 1.31891162117757e-37 MirTarget;TargetScan -0.178883279727291 1.06830894015488e-26 NA NA NA hsa-miR-141-3p SLC14A1 2.99777540204168 1.26370498493024e-78 -1.8296766628693 9.14954794554873e-24 TargetScan -0.324237091875429 9.00417486903223e-20 NA NA NA hsa-miR-200b-3p SLC14A1 2.11744072703209 1.66710572104191e-43 -1.8296766628693 9.14954794554873e-24 TargetScan -0.311176163082337 1.74189306346151e-15 NA NA NA hsa-miR-200c-3p SLC14A1 2.07038651806183 6.84613386286599e-51 -1.8296766628693 9.14954794554873e-24 miRNATAP -0.347223954857555 6.45997490756871e-16 NA NA NA hsa-miR-429 SLC14A1 2.84108892259147 3.88520896426515e-64 -1.8296766628693 9.14954794554873e-24 miRanda;miRNATAP -0.314295047111621 1.42196628559147e-19 NA NA NA hsa-miR-141-5p SLC16A1 2.38411349683216 4.56310582620282e-58 -0.264334727802715 0.0699179242466657 MirTarget -0.113129474500069 0.000297834434084182 NA NA NA hsa-miR-139-5p SLC16A10 -3.25846663863766 2.62018989415003e-112 0.0791934977495485 0.682670800754027 miRanda -0.139642594590718 0.000450190308805977 NA NA NA hsa-miR-200b-3p SLC16A10 2.11744072703209 1.66710572104191e-43 0.0791934977495485 0.682670800754027 TargetScan -0.114913640195792 0.00513309596711548 NA NA NA hsa-miR-200b-3p SLC16A12 2.11744072703209 1.66710572104191e-43 -3.39848844749063 9.41892581477195e-45 mirMAP -0.456144054108391 1.16013629771253e-17 NA NA NA hsa-miR-200c-3p SLC16A12 2.07038651806183 6.84613386286599e-51 -3.39848844749063 9.41892581477195e-45 mirMAP;miRNATAP -0.561685545355292 5.5854224423554e-22 NA NA NA hsa-miR-429 SLC16A12 2.84108892259147 3.88520896426515e-64 -3.39848844749063 9.41892581477195e-45 PITA;mirMAP;miRNATAP -0.529959336762374 1.15364825326493e-29 NA NA NA hsa-miR-200b-3p SLC16A2 2.11744072703209 1.66710572104191e-43 -0.95630968138008 1.13011064231398e-14 TargetScan -0.243509194495021 1.00286443031056e-20 NA NA NA hsa-miR-200c-3p SLC16A2 2.07038651806183 6.84613386286599e-51 -0.95630968138008 1.13011064231398e-14 miRNATAP -0.227815573584986 3.14634930478917e-15 NA NA NA hsa-miR-429 SLC16A2 2.84108892259147 3.88520896426515e-64 -0.95630968138008 1.13011064231398e-14 PITA;miRanda;miRNATAP -0.220385160229797 2.83123018181345e-21 NA NA NA hsa-miR-10b-5p SLC16A3 -2.10996264627796 7.36811595736367e-72 2.45447199270102 5.09719322612286e-56 mirMAP -0.566554988811786 8.70801288451453e-41 NA NA NA hsa-miR-139-5p SLC16A6 -3.25846663863766 2.62018989415003e-112 1.58051174117426 2.78683595021654e-10 PITA;miRanda -0.150929626252266 0.00378794878362354 NA NA NA hsa-miR-486-5p SLC16A6 -3.87258704301474 1.22658629378451e-80 1.58051174117426 2.78683595021654e-10 miRanda -0.17476533231183 5.12666251006391e-06 NA NA NA hsa-miR-141-3p SLC16A7 2.99777540204168 1.26370498493024e-78 -3.49994018987621 1.09074280789303e-67 MirTarget;TargetScan;miRNATAP -0.672247379575729 1.31094948652569e-65 NA NA NA hsa-miR-200a-3p SLC16A7 2.55218480823434 2.96135446816238e-51 -3.49994018987621 1.09074280789303e-67 MirTarget;miRNATAP -0.576868164998192 1.64573525873859e-48 NA NA NA hsa-miR-96-5p SLC16A7 3.24596558166606 1.92296159041707e-98 -3.49994018987621 1.09074280789303e-67 TargetScan;miRNATAP -0.660232374980251 1.58352378234477e-60 NA NA NA hsa-miR-21-5p SLC17A5 2.32007501846389 3.08394781855554e-137 -0.25995750361683 0.000551791743076125 miRNAWalker2_validate -0.141717076512453 1.15572536843549e-09 NA NA NA hsa-miR-429 SLC17A7 2.84108892259147 3.88520896426515e-64 -3.17699922580636 2.40871494566018e-76 miRNATAP -0.517866207265146 8.82342864838244e-54 NA NA NA hsa-miR-141-3p SLC18A2 2.99777540204168 1.26370498493024e-78 -0.432909078275727 0.0823913549987578 TargetScan -0.432720969950804 6.8958260273963e-20 NA NA NA hsa-miR-145-5p SLC19A1 -2.62703571936687 7.64402900188551e-88 1.16604634033933 5.44851189110219e-30 mirMAP -0.263706295907264 2.3806645193202e-28 NA NA NA hsa-miR-429 SLC19A3 2.84108892259147 3.88520896426515e-64 -5.70986170826113 7.89669400953176e-68 miRanda -0.7675414675966 5.53361778570221e-32 NA NA NA hsa-miR-145-5p SLC1A2 -2.62703571936687 7.64402900188551e-88 0.459709222651274 0.0428564210643349 miRNATAP -0.112629559267915 0.032963469463296 NA NA NA hsa-miR-224-5p SLC1A2 -2.22249420723892 1.07787949391113e-18 0.459709222651274 0.0428564210643349 mirMAP -0.25440787900545 8.99142905055228e-18 NA NA NA hsa-miR-511-5p SLC1A2 -2.27545475897362 3.84085514050558e-36 0.459709222651274 0.0428564210643349 MirTarget -0.180452233552669 1.19507222523122e-05 NA NA NA hsa-miR-145-5p SLC1A4 -2.62703571936687 7.64402900188551e-88 0.992481327676417 1.78777880902533e-17 MirTarget -0.171130691142078 4.20774536235485e-10 NA NA NA hsa-miR-335-5p SLC1A4 -2.61355235628987 2.6462884165886e-51 0.992481327676417 1.78777880902533e-17 miRNAWalker2_validate -0.110812509061541 4.72163565483372e-07 NA NA NA hsa-miR-139-5p SLC1A6 -3.25846663863766 2.62018989415003e-112 0.00718042576873668 0.98151393687217 miRanda -0.186208707730148 0.0034878746033499 NA NA NA hsa-miR-141-3p SLC1A7 2.99777540204168 1.26370498493024e-78 -1.89898960979584 3.58937473841316e-24 MirTarget -0.543968074363888 2.36542113295882e-54 NA NA NA hsa-miR-200a-3p SLC1A7 2.55218480823434 2.96135446816238e-51 -1.89898960979584 3.58937473841316e-24 MirTarget -0.410477326911047 5.07202701771004e-31 NA NA NA hsa-miR-335-5p SLC22A15 -2.61355235628987 2.6462884165886e-51 0.770140030987174 1.27030257384228e-09 miRNAWalker2_validate -0.112084311073242 2.24263222545743e-06 NA NA NA hsa-miR-452-5p SLC22A15 -2.48486455572568 1.24430987974325e-33 0.770140030987174 1.27030257384228e-09 MirTarget -0.171865485367672 1.14639917801994e-17 NA NA NA hsa-miR-511-5p SLC22A17 -2.27545475897362 3.84085514050558e-36 -0.21174084728872 0.130280695362021 MirTarget -0.123623411745937 1.08049771933726e-06 NA NA NA hsa-miR-335-5p SLC22A18 -2.61355235628987 2.6462884165886e-51 1.25260276601379 1.23743215904556e-21 miRNAWalker2_validate -0.148922410925239 1.85908191429336e-09 NA NA NA hsa-miR-141-3p SLC23A2 2.99777540204168 1.26370498493024e-78 -0.863704929171444 4.7965754192839e-26 TargetScan;miRNATAP -0.121431806885343 5.87856476077752e-14 NA NA NA hsa-miR-200a-3p SLC23A2 2.55218480823434 2.96135446816238e-51 -0.863704929171444 4.7965754192839e-26 miRNATAP -0.124355379652701 4.1008352288661e-15 NA NA NA hsa-miR-200b-3p SLC23A2 2.11744072703209 1.66710572104191e-43 -0.863704929171444 4.7965754192839e-26 TargetScan -0.12919286969364 2.53988985643544e-13 NA NA NA hsa-miR-200c-3p SLC23A2 2.07038651806183 6.84613386286599e-51 -0.863704929171444 4.7965754192839e-26 miRNATAP -0.137994810466558 1.24212912554401e-12 NA NA NA hsa-miR-429 SLC23A2 2.84108892259147 3.88520896426515e-64 -0.863704929171444 4.7965754192839e-26 PITA;miRanda;miRNATAP -0.12725253062303 5.53150140945027e-16 NA NA NA hsa-miR-511-5p SLC24A2 -2.27545475897362 3.84085514050558e-36 4.28884058406051 8.68537645612283e-51 MirTarget -0.437435619726759 1.19023429522825e-15 NA NA NA hsa-miR-429 SLC24A3 2.84108892259147 3.88520896426515e-64 -0.636305851321917 0.000123032945895802 miRNATAP -0.124395616872075 7.54108179731004e-05 NA NA NA hsa-miR-183-5p SLC25A20 2.95681814393872 1.09965777344285e-92 -0.711288170121051 1.33620441335039e-21 MirTarget -0.145729159549069 1.91011884756397e-20 NA NA NA hsa-miR-335-5p SLC25A22 -2.61355235628987 2.6462884165886e-51 1.58690352640779 1.42340750706587e-60 mirMAP -0.208365983426791 9.50839137146776e-29 NA NA NA hsa-miR-429 SLC25A25 2.84108892259147 3.88520896426515e-64 -0.835572585237981 4.15643017002412e-20 miRNATAP -0.11819961760061 1.21627985272498e-11 NA NA NA hsa-miR-96-5p SLC25A25 3.24596558166606 1.92296159041707e-98 -0.835572585237981 4.15643017002412e-20 MirTarget;TargetScan;miRNATAP -0.152807735612757 2.71680073430966e-17 NA NA NA hsa-miR-429 SLC25A27 2.84108892259147 3.88520896426515e-64 -2.61338542336168 2.5890385711066e-47 PITA;miRanda -0.267705987708534 8.28713187273529e-14 NA NA NA hsa-miR-429 SLC25A30 2.84108892259147 3.88520896426515e-64 -0.866582635204202 1.6087013078525e-27 miRanda -0.118797086502622 1.05321826757249e-14 NA NA NA hsa-miR-182-5p SLC25A34 2.36408084103818 2.60011457600281e-72 -1.37175640553191 6.4905054963131e-29 mirMAP -0.220131357395243 1.91993229103044e-13 NA NA NA hsa-miR-141-3p SLC25A46 2.99777540204168 1.26370498493024e-78 -0.513843125053454 3.35662306138939e-12 MirTarget -0.100806025704897 2.08947325152253e-12 NA NA NA hsa-miR-200a-3p SLC25A46 2.55218480823434 2.96135446816238e-51 -0.513843125053454 3.35662306138939e-12 MirTarget -0.108934274784796 8.08657424954748e-15 NA NA NA hsa-miR-10b-5p SLC25A5 -2.10996264627796 7.36811595736367e-72 0.591608852874755 3.99942351799164e-19 miRNAWalker2_validate -0.195072790160239 3.60469652579299e-29 NA NA NA hsa-miR-21-5p SLC26A2 2.32007501846389 3.08394781855554e-137 -0.674297968214367 6.14915549790934e-09 miRNAWalker2_validate;mirMAP -0.230833931172102 1.65545587085468e-10 NA NA NA hsa-miR-429 SLC26A3 2.84108892259147 3.88520896426515e-64 -2.81725286544275 7.31729718395371e-13 miRanda -0.420666006270455 2.00094659041392e-08 NA NA NA hsa-miR-429 SLC26A4 2.84108892259147 3.88520896426515e-64 -2.0558733252402 3.24917848532999e-28 miRanda -0.222225688392312 9.07205485299536e-10 NA NA NA hsa-miR-96-5p SLC26A4 3.24596558166606 1.92296159041707e-98 -2.0558733252402 3.24917848532999e-28 TargetScan -0.271873249000871 5.62579459528648e-13 NA NA NA hsa-miR-141-3p SLC26A7 2.99777540204168 1.26370498493024e-78 -1.96069655415711 3.3510326452543e-20 miRNATAP -0.319706155473982 1.97656751822853e-14 NA NA NA hsa-miR-200a-3p SLC26A7 2.55218480823434 2.96135446816238e-51 -1.96069655415711 3.3510326452543e-20 miRNATAP -0.274025498134873 2.78872693365199e-11 NA NA NA hsa-miR-429 SLC26A7 2.84108892259147 3.88520896426515e-64 -1.96069655415711 3.3510326452543e-20 miRanda -0.2173960376193 1.20759354553436e-07 NA NA NA hsa-miR-429 SLC28A3 2.84108892259147 3.88520896426515e-64 -3.09072509899831 4.2682077886545e-18 miRNATAP -0.229390051865923 0.000872708398094434 NA NA NA hsa-miR-375 SLC2A12 2.09893673049766 1.68351780396203e-16 -1.40463552306912 2.97069732350071e-24 miRanda -0.154861735545829 4.36420514041692e-17 NA NA NA hsa-miR-429 SLC2A13 2.84108892259147 3.88520896426515e-64 -0.422835174294749 0.000265130322874232 miRanda -0.111359228765302 3.68840458692214e-07 NA NA NA hsa-miR-200b-3p SLC2A14 2.11744072703209 1.66710572104191e-43 -0.369226184374921 0.0199885519923262 TargetScan -0.20428957691275 9.51537026310353e-10 NA NA NA hsa-miR-182-5p SLC2A3 2.36408084103818 2.60011457600281e-72 -0.73181329100781 1.70465019063554e-09 MirTarget -0.247582450899895 5.66868226129936e-18 NA NA NA hsa-miR-183-5p SLC2A3 2.95681814393872 1.09965777344285e-92 -0.73181329100781 1.70465019063554e-09 miRNAWalker2_validate -0.181776725858749 1.06459586304762e-12 NA NA NA hsa-miR-200b-3p SLC2A3 2.11744072703209 1.66710572104191e-43 -0.73181329100781 1.70465019063554e-09 TargetScan -0.246919672638004 2.12061845210017e-22 NA NA NA hsa-miR-429 SLC2A3 2.84108892259147 3.88520896426515e-64 -0.73181329100781 1.70465019063554e-09 miRanda -0.200055324710204 1.51649482765766e-18 NA NA NA hsa-miR-200b-3p SLC30A4 2.11744072703209 1.66710572104191e-43 -1.00448774952403 3.52868937206263e-14 mirMAP -0.200097064595424 1.31859002033996e-12 NA NA NA hsa-miR-200c-3p SLC30A4 2.07038651806183 6.84613386286599e-51 -1.00448774952403 3.52868937206263e-14 mirMAP -0.212818921568938 7.23074054227763e-12 NA NA NA hsa-miR-429 SLC30A4 2.84108892259147 3.88520896426515e-64 -1.00448774952403 3.52868937206263e-14 mirMAP -0.201717681531683 8.95256309772324e-16 NA NA NA hsa-miR-139-5p SLC30A8 -3.25846663863766 2.62018989415003e-112 2.07757230125667 1.63191940569709e-05 miRanda -0.22813779665676 0.022261851184069 NA NA NA hsa-miR-139-5p SLC35A2 -3.25846663863766 2.62018989415003e-112 1.37558630624444 1.43951398992392e-91 miRanda -0.247629660098914 3.06180187188839e-66 NA NA NA hsa-miR-182-5p SLC35B4 2.36408084103818 2.60011457600281e-72 -0.555899913231548 3.16789637131235e-18 miRNATAP -0.125063826227916 2.32165309602919e-16 NA NA NA hsa-miR-200b-3p SLC35B4 2.11744072703209 1.66710572104191e-43 -0.555899913231548 3.16789637131235e-18 MirTarget -0.161992299664321 2.27816701383122e-34 NA NA NA hsa-miR-200c-3p SLC35B4 2.07038651806183 6.84613386286599e-51 -0.555899913231548 3.16789637131235e-18 MirTarget -0.175344958332148 2.91548046690508e-33 NA NA NA hsa-miR-429 SLC35B4 2.84108892259147 3.88520896426515e-64 -0.555899913231548 3.16789637131235e-18 MirTarget;miRanda -0.117281732034517 1.70864455734796e-22 NA NA NA hsa-miR-96-5p SLC35B4 3.24596558166606 1.92296159041707e-98 -0.555899913231548 3.16789637131235e-18 TargetScan -0.102253469005703 6.50328815067112e-16 NA NA NA hsa-miR-429 SLC35F1 2.84108892259147 3.88520896426515e-64 -1.56128451162718 3.51037175111893e-26 miRanda;miRNATAP -0.279186055863556 2.75526790374699e-23 NA NA NA hsa-miR-139-5p SLC35F2 -3.25846663863766 2.62018989415003e-112 0.878268448289617 1.09766152320747e-12 miRanda -0.184640360717491 3.73386600291341e-13 NA NA NA hsa-miR-429 SLC35F3 2.84108892259147 3.88520896426515e-64 -2.21095167498508 5.51776497402454e-15 miRNATAP -0.157468980122841 0.00387374276487078 NA NA NA hsa-miR-335-5p SLC37A1 -2.61355235628987 2.6462884165886e-51 1.34571546841472 5.70326099177598e-57 miRNAWalker2_validate -0.146679266085791 7.00213401174656e-19 NA NA NA hsa-miR-486-5p SLC38A1 -3.87258704301474 1.22658629378451e-80 0.674531310081938 3.46663107125937e-06 miRanda -0.1456867175427 3.29623758015021e-11 NA NA NA hsa-miR-200b-3p SLC38A2 2.11744072703209 1.66710572104191e-43 -0.364510037668315 1.63048534493323e-06 TargetScan -0.102576990287577 1.61535790466886e-10 NA NA NA hsa-miR-182-5p SLC38A4 2.36408084103818 2.60011457600281e-72 -1.2347561385374 5.74044454848711e-08 miRNATAP -0.262123253891967 1.4515076680888e-06 NA NA NA hsa-miR-200b-3p SLC38A4 2.11744072703209 1.66710572104191e-43 -1.2347561385374 5.74044454848711e-08 TargetScan -0.412658111018875 5.13750242493235e-18 NA NA NA hsa-miR-200c-3p SLC38A4 2.07038651806183 6.84613386286599e-51 -1.2347561385374 5.74044454848711e-08 miRNATAP -0.438978338568797 6.49074569786995e-17 NA NA NA hsa-miR-429 SLC38A4 2.84108892259147 3.88520896426515e-64 -1.2347561385374 5.74044454848711e-08 PITA;miRanda;miRNATAP -0.343484540610116 9.03847734042981e-16 NA NA NA hsa-miR-96-5p SLC38A4 3.24596558166606 1.92296159041707e-98 -1.2347561385374 5.74044454848711e-08 TargetScan;miRNATAP -0.350617464785373 3.99868735240555e-15 NA NA NA hsa-miR-139-5p SLC39A1 -3.25846663863766 2.62018989415003e-112 0.808771764479105 1.67271591807527e-42 miRanda -0.139514137710105 1.93436960097116e-29 NA NA NA hsa-miR-139-5p SLC39A11 -3.25846663863766 2.62018989415003e-112 1.34576774324297 3.67536017511431e-35 miRanda -0.245115536816348 2.64983707320767e-27 NA NA NA hsa-miR-200b-3p SLC39A14 2.11744072703209 1.66710572104191e-43 -0.293760372853095 0.000951980302976168 TargetScan -0.114029097070864 1.12589864919249e-09 NA NA NA hsa-miR-139-5p SLC39A7 -3.25846663863766 2.62018989415003e-112 1.07429403422188 9.02532975876471e-44 miRanda -0.191550054036837 2.5244714582043e-32 NA NA NA hsa-miR-429 SLC40A1 2.84108892259147 3.88520896426515e-64 -0.590550152905235 0.00639671366873554 miRanda -0.253326116192498 4.90317491628866e-10 NA NA NA hsa-miR-452-5p SLC44A1 -2.48486455572568 1.24430987974325e-33 0.356538876894333 8.49617554267559e-07 mirMAP -0.111348040705478 8.46407895569039e-23 NA NA NA hsa-miR-224-5p SLC4A10 -2.22249420723892 1.07787949391113e-18 -0.508336460093803 0.0887268131029271 MirTarget -0.141934732191965 0.00034677614157337 NA NA NA hsa-miR-182-5p SLC4A4 2.36408084103818 2.60011457600281e-72 -3.22244872974772 4.4074843483247e-37 mirMAP -0.502337307801548 6.41775650845729e-16 NA NA NA hsa-miR-200b-3p SLC4A4 2.11744072703209 1.66710572104191e-43 -3.22244872974772 4.4074843483247e-37 TargetScan;mirMAP -0.449960835100903 4.16743191764243e-16 NA NA NA hsa-miR-200c-3p SLC4A4 2.07038651806183 6.84613386286599e-51 -3.22244872974772 4.4074843483247e-37 mirMAP -0.625325407454527 2.32713383697721e-25 NA NA NA hsa-miR-429 SLC4A4 2.84108892259147 3.88520896426515e-64 -3.22244872974772 4.4074843483247e-37 PITA;miRanda;mirMAP;miRNATAP -0.421949715989673 1.1368272005056e-17 NA NA NA hsa-miR-139-5p SLC4A8 -3.25846663863766 2.62018989415003e-112 1.27143188110937 7.46578845328289e-09 miRanda -0.108001058158629 0.0181922967717444 NA NA NA hsa-miR-486-5p SLC4A8 -3.87258704301474 1.22658629378451e-80 1.27143188110937 7.46578845328289e-09 miRanda;miRNATAP -0.180006995191307 7.84936085374344e-08 NA NA NA hsa-miR-182-5p SLC5A12 2.36408084103818 2.60011457600281e-72 -0.621646477055828 0.0122063232888974 mirMAP -0.271464870903015 4.12008029970935e-06 NA NA NA hsa-miR-429 SLC5A12 2.84108892259147 3.88520896426515e-64 -0.621646477055828 0.0122063232888974 miRanda -0.157417518998651 0.000809191842829048 NA NA NA hsa-miR-96-5p SLC5A12 3.24596558166606 1.92296159041707e-98 -0.621646477055828 0.0122063232888974 mirMAP -0.183110761576983 0.000187123821696754 NA NA NA hsa-miR-141-3p SLC5A3 2.99777540204168 1.26370498493024e-78 -0.728564527931595 1.72377411389955e-12 TargetScan -0.13477828857689 2.10360180609674e-11 NA NA NA hsa-miR-200b-3p SLC5A3 2.11744072703209 1.66710572104191e-43 -0.728564527931595 1.72377411389955e-12 TargetScan -0.170267039473142 6.6340782575264e-15 NA NA NA hsa-miR-21-5p SLC5A3 2.32007501846389 3.08394781855554e-137 -0.728564527931595 1.72377411389955e-12 miRNAWalker2_validate -0.159656869345367 8.71109577015147e-07 NA NA NA hsa-miR-429 SLC5A3 2.84108892259147 3.88520896426515e-64 -0.728564527931595 1.72377411389955e-12 miRNATAP -0.124069310592054 2.62976690710842e-10 NA NA NA hsa-miR-200c-3p SLC6A1 2.07038651806183 6.84613386286599e-51 0.695876879485252 2.15002129204297e-07 MirTarget;miRNATAP -0.107537028534499 0.000635484155424555 NA NA NA hsa-miR-335-5p SLC6A12 -2.61355235628987 2.6462884165886e-51 0.463211150795502 0.00286108782471287 miRNAWalker2_validate -0.119350226183298 3.46711824612165e-05 NA NA NA hsa-miR-429 SLC6A15 2.84108892259147 3.88520896426515e-64 -2.64559326226847 2.18980588731198e-14 miRanda;miRNATAP -0.26843024223584 5.46844402003655e-05 NA NA NA hsa-miR-182-5p SLC6A17 2.36408084103818 2.60011457600281e-72 0.516244189333382 0.0254872450633986 mirMAP -0.124441862072127 0.0240603730951284 NA NA NA hsa-miR-486-5p SLC6A4 -3.87258704301474 1.22658629378451e-80 0.832715997717498 0.0306047620635539 miRanda -0.156408862585518 0.0075770352686516 NA NA NA hsa-miR-335-5p SLC6A9 -2.61355235628987 2.6462884165886e-51 1.430284713828 3.22138443819342e-24 miRNAWalker2_validate -0.231374424141028 1.9165126499056e-18 NA NA NA hsa-miR-10b-5p SLC7A5 -2.10996264627796 7.36811595736367e-72 2.14974765643279 1.74270629714836e-31 mirMAP -0.688264141683385 3.06418095761599e-46 NA NA NA hsa-miR-141-5p SLC7A6 2.38411349683216 4.56310582620282e-58 -0.384247758575761 9.6427629734149e-10 mirMAP -0.116110270336542 3.09340664311902e-18 NA NA NA hsa-miR-21-5p SLC7A6 2.32007501846389 3.08394781855554e-137 -0.384247758575761 9.6427629734149e-10 miRNATAP -0.127162122697708 7.65678085510232e-11 NA NA NA hsa-miR-96-5p SLC8A1 3.24596558166606 1.92296159041707e-98 -0.707245058238919 1.30040005188852e-10 TargetScan -0.184792723833741 1.07848863179816e-17 NA NA NA hsa-miR-335-5p SLC9A3R1 -2.61355235628987 2.6462884165886e-51 1.87573987319657 1.0023464468029e-38 miRNAWalker2_validate -0.188959857561066 1.03444380124704e-11 NA NA NA hsa-miR-141-3p SLC9A6 2.99777540204168 1.26370498493024e-78 -1.03941495653485 7.45048393740663e-22 mirMAP -0.185428095619169 1.79953429672627e-18 NA NA NA hsa-miR-196a-5p SLC9A6 2.33423717464504 3.646557504928e-18 -1.03941495653485 7.45048393740663e-22 MirTarget;miRNATAP -0.106072670287888 7.23329786294574e-15 NA NA NA hsa-miR-200a-3p SLC9A6 2.55218480823434 2.96135446816238e-51 -1.03941495653485 7.45048393740663e-22 mirMAP -0.163168904804147 4.90022989227962e-15 NA NA NA hsa-miR-21-5p SLC9A6 2.32007501846389 3.08394781855554e-137 -1.03941495653485 7.45048393740663e-22 miRNAWalker2_validate;miRNATAP -0.27005054250097 2.15261298062036e-15 NA NA NA hsa-miR-429 SLC9A6 2.84108892259147 3.88520896426515e-64 -1.03941495653485 7.45048393740663e-22 PITA;miRanda;miRNATAP -0.154897114285611 7.92483828251631e-14 NA NA NA hsa-miR-141-5p SLCO1A2 2.38411349683216 4.56310582620282e-58 -4.24863756283348 9.152442420102e-44 mirMAP -0.294817207417724 2.0940356055674e-05 NA NA NA hsa-miR-182-5p SLCO1A2 2.36408084103818 2.60011457600281e-72 -4.24863756283348 9.152442420102e-44 mirMAP -0.69049950221301 5.37430566167515e-20 NA NA NA hsa-miR-200a-5p SLCO1A2 2.58844508672328 1.79650654234569e-56 -4.24863756283348 9.152442420102e-44 MirTarget -0.341072450294319 5.59972982036332e-08 NA NA NA hsa-miR-429 SLCO2A1 2.84108892259147 3.88520896426515e-64 -0.279862140595032 0.0197651891799429 miRNATAP -0.144123452594475 1.59244040191729e-10 NA NA NA hsa-miR-182-5p SLCO2B1 2.36408084103818 2.60011457600281e-72 -0.401022972274025 0.000275796248609183 MirTarget -0.206472037124816 1.62002267547241e-15 NA NA NA hsa-miR-182-5p SLCO3A1 2.36408084103818 2.60011457600281e-72 -0.914954954815147 1.13272167018896e-14 MirTarget;miRNATAP -0.223160949477889 2.71594028421374e-15 NA NA NA hsa-miR-429 SLCO3A1 2.84108892259147 3.88520896426515e-64 -0.914954954815147 1.13272167018896e-14 miRNATAP -0.159580883564309 1.39744391444532e-12 NA NA NA hsa-miR-96-5p SLCO3A1 3.24596558166606 1.92296159041707e-98 -0.914954954815147 1.13272167018896e-14 TargetScan;miRNATAP -0.217864372179916 7.39992122956799e-21 NA NA NA hsa-miR-486-5p SLCO5A1 -3.87258704301474 1.22658629378451e-80 1.52741878516811 8.47804781115758e-13 miRanda -0.141283901733144 1.65653000081142e-05 NA NA NA hsa-miR-429 SLFN12 2.84108892259147 3.88520896426515e-64 -0.69287126512263 1.34042933944534e-09 miRanda -0.144099514592959 2.65546982095814e-11 NA NA NA hsa-miR-96-5p SLFN12 3.24596558166606 1.92296159041707e-98 -0.69287126512263 1.34042933944534e-09 TargetScan -0.180722722035509 7.90982571481985e-16 NA NA NA hsa-miR-141-5p SLFN5 2.38411349683216 4.56310582620282e-58 -1.27805096676886 2.39933329023955e-18 mirMAP -0.193060913935447 1.31026787197162e-09 NA NA NA hsa-miR-200b-3p SLFN5 2.11744072703209 1.66710572104191e-43 -1.27805096676886 2.39933329023955e-18 mirMAP -0.248980820279927 1.4176589281827e-15 NA NA NA hsa-miR-200c-3p SLFN5 2.07038651806183 6.84613386286599e-51 -1.27805096676886 2.39933329023955e-18 mirMAP -0.287583073935163 4.35379942889239e-17 NA NA NA hsa-miR-21-5p SLFN5 2.32007501846389 3.08394781855554e-137 -1.27805096676886 2.39933329023955e-18 mirMAP -0.270331943733987 4.96688585043486e-09 NA NA NA hsa-miR-429 SLFN5 2.84108892259147 3.88520896426515e-64 -1.27805096676886 2.39933329023955e-18 mirMAP -0.236237057414537 1.82371056985733e-17 NA NA NA hsa-miR-429 SLIT1 2.84108892259147 3.88520896426515e-64 -0.429876941630699 0.0690557317419597 miRanda -0.100475984706962 0.0250390169870855 NA NA NA hsa-miR-200b-3p SLIT2 2.11744072703209 1.66710572104191e-43 -1.96479460453985 2.09695722427889e-22 TargetScan -0.431271705406123 6.75929574300841e-24 NA NA NA hsa-miR-429 SLIT3 2.84108892259147 3.88520896426515e-64 -2.26432098697292 2.92136586837965e-51 miRNATAP -0.412659633647214 5.82358018683184e-47 NA NA NA hsa-miR-96-5p SLIT3 3.24596558166606 1.92296159041707e-98 -2.26432098697292 2.92136586837965e-51 TargetScan -0.441828765991714 1.19052500151293e-49 NA NA NA hsa-miR-182-5p SLITRK4 2.36408084103818 2.60011457600281e-72 -1.25800996515142 4.786961418459e-12 MirTarget;miRNATAP -0.344905354088246 1.49432246167871e-15 NA NA NA hsa-miR-200a-5p SLITRK4 2.58844508672328 1.79650654234569e-56 -1.25800996515142 4.786961418459e-12 miRNATAP -0.230026239370276 1.12130433617893e-10 NA NA NA hsa-miR-429 SLITRK4 2.84108892259147 3.88520896426515e-64 -1.25800996515142 4.786961418459e-12 miRNATAP -0.25885418076617 5.64114475916965e-14 NA NA NA hsa-miR-96-5p SLITRK4 3.24596558166606 1.92296159041707e-98 -1.25800996515142 4.786961418459e-12 TargetScan;miRNATAP -0.321555091648165 2.07026295047038e-19 NA NA NA hsa-miR-429 SLITRK5 2.84108892259147 3.88520896426515e-64 -1.84511085900968 9.39081253158965e-11 miRanda -0.156650654061851 0.00411359129926043 NA NA NA hsa-miR-486-5p SLITRK6 -3.87258704301474 1.22658629378451e-80 0.369044274947357 0.302005321896914 miRanda -0.215062895305043 7.20808165267197e-05 NA NA NA hsa-miR-21-5p SLK 2.32007501846389 3.08394781855554e-137 -0.57237953827141 7.90930897832754e-14 miRNAWalker2_validate -0.209515781521834 1.03916806668674e-18 NA NA NA hsa-miR-21-5p SLMAP 2.32007501846389 3.08394781855554e-137 -0.488101371423336 8.62299343397482e-13 miRNAWalker2_validate;MirTarget -0.194986340943015 2.01853738483389e-20 NA NA NA hsa-miR-181a-5p SMAD2 0.635863607630183 6.72486918157744e-11 -0.328226721195286 1.10147955577876e-10 mirMAP -0.115122429788219 8.47012412856965e-11 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.22749257795094 1.21998198830919e-27 -0.328226721195286 1.10147955577876e-10 mirMAP -0.112879931507918 3.62142519922135e-14 NA NA NA hsa-miR-340-5p SMAD2 1.0857159627596 4.94471062546756e-24 -0.328226721195286 1.10147955577876e-10 MirTarget -0.145840275032375 8.51041709723394e-21 NA NA NA hsa-miR-361-3p SMAD2 -0.0370446538644886 0.624902392829872 -0.328226721195286 1.10147955577876e-10 miRNATAP -0.128521633108847 3.38235989722682e-08 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 -0.0996867547900457 0.095428250126326 -0.328226721195286 1.10147955577876e-10 MirTarget -0.168440579811925 1.40285064429544e-08 NA NA NA hsa-miR-542-3p SMAD2 0.568822103820889 8.5699075257651e-07 -0.328226721195286 1.10147955577876e-10 PITA -0.104251622984305 3.31535587210055e-12 NA NA NA hsa-miR-155-5p SMAD3 1.09766314984151 4.55650930885814e-15 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-15a-5p SMAD3 0.812445324157528 4.50263417099822e-20 -0.590930154862025 2.18041656438712e-13 MirTarget -0.127238885845652 3.99211956272264e-05 NA NA NA hsa-miR-15b-5p SMAD3 0.788659356634696 1.13678211092534e-11 -0.590930154862025 2.18041656438712e-13 MirTarget -0.103829420518863 1.25324379645245e-05 NA NA NA hsa-miR-17-5p SMAD3 0.599531757298529 1.07318660415906e-05 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 NA NA NA hsa-miR-185-5p SMAD3 0.482334746589337 3.68475879959415e-09 -0.590930154862025 2.18041656438712e-13 MirTarget -0.139641114876277 4.17733017511663e-05 NA NA NA hsa-miR-18a-5p SMAD3 0.969066793715868 1.69069796425892e-08 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-1976 SMAD3 0.289190368864725 0.00167092758216584 -0.590930154862025 2.18041656438712e-13 MirTarget -0.121630671332983 6.52049342337766e-05 NA NA NA hsa-miR-28-5p SMAD3 -0.14267073663385 0.0497619246260571 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.120097254990824 0.00200641803458376 NA NA NA hsa-miR-330-5p SMAD3 0.626063225953928 3.42215028606779e-09 -0.590930154862025 2.18041656438712e-13 miRanda -0.106180722787539 5.07248451793749e-05 NA NA NA hsa-miR-429 SMAD3 2.84108892259147 3.88520896426515e-64 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.102063359852527 2.55000912428033e-11 NA NA NA hsa-miR-590-3p SMAD3 1.27438512890514 1.03164723481469e-23 -0.590930154862025 2.18041656438712e-13 miRanda -0.163099760014662 1.73477690677951e-13 NA NA NA hsa-miR-671-5p SMAD3 1.55248047544015 7.7377784125886e-33 -0.590930154862025 2.18041656438712e-13 MirTarget -0.132445297015047 2.33568059728177e-10 NA NA NA hsa-miR-769-5p SMAD3 0.564871766265874 8.16695101656941e-10 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.121091427985316 6.14487597806327e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.22477789913175 2.31787213143326e-32 -0.624967182926059 1.70248077700642e-24 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 NA NA NA hsa-miR-146b-5p SMAD4 0.631041661167954 6.20366593452965e-08 -0.624967182926059 1.70248077700642e-24 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 1.09766314984151 4.55650930885814e-15 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-21-3p SMAD4 2.17476065946878 5.15299442583591e-75 -0.624967182926059 1.70248077700642e-24 mirMAP -0.142251679213528 1.79438322002583e-18 NA NA NA hsa-miR-27a-3p SMAD4 0.388496361379095 1.42373532086331e-05 -0.624967182926059 1.70248077700642e-24 MirTarget -0.107318887613883 7.95509636261065e-06 NA NA NA hsa-miR-32-5p SMAD4 1.38676603945192 2.29428299685976e-34 -0.624967182926059 1.70248077700642e-24 mirMAP -0.104053876543456 9.38449586813502e-09 NA NA NA hsa-miR-361-5p SMAD4 -0.0996867547900457 0.095428250126326 -0.624967182926059 1.70248077700642e-24 mirMAP -0.13420862344236 0.000247319809078657 NA NA NA hsa-miR-589-5p SMAD4 0.367182541239722 1.67804815542873e-05 -0.624967182926059 1.70248077700642e-24 miRNATAP -0.184456440754787 1.53364140974385e-13 NA NA NA hsa-miR-93-5p SMAD4 1.01788600209314 1.24312921618126e-21 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 NA NA NA hsa-miR-429 SMAD6 2.84108892259147 3.88520896426515e-64 -0.553769610178168 7.58185937032009e-08 miRanda -0.1319320154552 1.11141762738611e-11 NA NA NA hsa-miR-200b-3p SMAD9 2.11744072703209 1.66710572104191e-43 -2.31742580561337 5.2619763732892e-36 TargetScan -0.433450642046697 1.02300809234532e-27 NA NA NA hsa-miR-429 SMAD9 2.84108892259147 3.88520896426515e-64 -2.31742580561337 5.2619763732892e-36 miRanda;miRNATAP -0.411129629446905 2.43654737649883e-31 NA NA NA hsa-miR-429 SMARCA1 2.84108892259147 3.88520896426515e-64 -0.771129677596766 4.22068394136165e-09 miRanda -0.168552931477383 1.085078885511e-11 NA NA NA hsa-miR-139-5p SMARCA4 -3.25846663863766 2.62018989415003e-112 1.06059180222474 7.20878696633532e-56 PITA;miRanda;miRNATAP -0.210088258862057 2.62276153887102e-51 NA NA NA hsa-miR-337-3p SMARCB1 -2.14274617598363 2.70942896809734e-43 0.612318654674613 1.63590438363354e-23 PITA -0.103352291059688 1.36875970478513e-15 NA NA NA hsa-miR-139-5p SMC4 -3.25846663863766 2.62018989415003e-112 1.30814050314395 5.90073370034915e-40 miRanda -0.285782530205798 2.5598429827376e-45 NA NA NA hsa-miR-486-5p SMC4 -3.87258704301474 1.22658629378451e-80 1.30814050314395 5.90073370034915e-40 miRanda -0.128531286512109 1.11979717399706e-16 NA NA NA hsa-miR-429 SMOC1 2.84108892259147 3.88520896426515e-64 -2.47292986848555 8.15998061815026e-19 miRNATAP -0.211505076631664 8.8644679132827e-05 NA NA NA hsa-miR-429 SMOC2 2.84108892259147 3.88520896426515e-64 -0.818777323409662 1.04293178790671e-07 miRNATAP -0.167654977037311 8.92152379034773e-09 NA NA NA hsa-miR-139-5p SMOX -3.25846663863766 2.62018989415003e-112 0.597385833771584 3.59825744635494e-06 miRNATAP -0.147279813244526 2.73711661124356e-08 NA NA NA hsa-miR-378a-5p SMPD3 -2.43173551693523 1.44932837789175e-68 0.615367305705764 0.000207141465036637 mirMAP -0.39706509069733 1.34225514122545e-27 NA NA NA hsa-miR-429 SMTNL2 2.84108892259147 3.88520896426515e-64 -1.64622395499438 3.71266524218448e-13 miRanda -0.2417532127333 2.29148049922538e-08 NA NA NA hsa-miR-375 SMYD1 2.09893673049766 1.68351780396203e-16 -5.59423095315222 4.87566775628026e-53 miRanda -0.339711636402984 2.54805404463676e-11 NA NA NA hsa-miR-182-5p SNAI2 2.36408084103818 2.60011457600281e-72 -0.929098872578741 6.81961748391463e-14 miRNAWalker2_validate;miRNATAP -0.310945077672776 1.14998297831868e-26 NA NA NA hsa-miR-200b-3p SNAI2 2.11744072703209 1.66710572104191e-43 -0.929098872578741 6.81961748391463e-14 TargetScan -0.244585452671317 7.0648050194561e-21 NA NA NA hsa-miR-200c-3p SNAI2 2.07038651806183 6.84613386286599e-51 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.286974732040298 1.03468820627389e-23 NA NA NA hsa-miR-375 SNAI2 2.09893673049766 1.68351780396203e-16 -0.929098872578741 6.81961748391463e-14 miRanda -0.147761834840226 9.62714562907298e-20 NA NA NA hsa-miR-429 SNAI2 2.84108892259147 3.88520896426515e-64 -0.929098872578741 6.81961748391463e-14 PITA;miRanda;miRNATAP -0.220374529254888 3.02724246604925e-21 NA NA NA hsa-miR-96-5p SNAI2 3.24596558166606 1.92296159041707e-98 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.280366193015972 1.4231591750163e-31 NA NA NA hsa-miR-141-3p SNAP91 2.99777540204168 1.26370498493024e-78 -0.916150785435058 0.000141100985259601 TargetScan;miRNATAP -0.180870642349008 0.000113546085491439 NA NA NA hsa-miR-200a-3p SNAP91 2.55218480823434 2.96135446816238e-51 -0.916150785435058 0.000141100985259601 miRNATAP -0.127118850477594 0.00579873268401079 NA NA NA hsa-miR-375 SNAP91 2.09893673049766 1.68351780396203e-16 -0.916150785435058 0.000141100985259601 miRanda -0.170345638080221 7.45496425624345e-08 NA NA NA hsa-miR-429 SNCA 2.84108892259147 3.88520896426515e-64 -1.99935505210561 3.8641383240741e-51 miRanda;miRNATAP -0.304683508078937 4.34704074376293e-32 NA NA NA hsa-miR-429 SNCAIP 2.84108892259147 3.88520896426515e-64 -1.75834987549192 8.02242075190131e-26 miRNATAP -0.345536359156039 1.00411146745706e-27 NA NA NA hsa-miR-21-5p SNED1 2.32007501846389 3.08394781855554e-137 -0.896350462657402 2.77604345772578e-14 miRNATAP -0.154303618359808 3.36056645429983e-05 NA NA NA hsa-miR-141-3p SNRK 2.99777540204168 1.26370498493024e-78 -0.9398548825191 1.18370519007903e-44 TargetScan -0.194155270998728 4.73516499977359e-51 NA NA NA hsa-miR-21-3p SNRK 2.17476065946878 5.15299442583591e-75 -0.9398548825191 1.18370519007903e-44 MirTarget -0.161056829046255 1.11705844406669e-18 NA NA NA hsa-miR-21-5p SNRK 2.32007501846389 3.08394781855554e-137 -0.9398548825191 1.18370519007903e-44 miRNAWalker2_validate -0.28713135980416 8.46878458998811e-43 NA NA NA hsa-miR-429 SNRK 2.84108892259147 3.88520896426515e-64 -0.9398548825191 1.18370519007903e-44 miRanda -0.16796884118099 1.85652070579679e-39 NA NA NA hsa-miR-486-5p SNRNP25 -3.87258704301474 1.22658629378451e-80 1.38680565834755 3.63473860587539e-53 miRanda -0.123695739054844 8.12252855848419e-18 NA NA NA hsa-miR-21-5p SNRNP48 2.32007501846389 3.08394781855554e-137 -0.194172245337089 0.00117253990961745 miRNAWalker2_validate -0.12263221492908 2.95778121000395e-11 NA NA NA hsa-miR-139-5p SNRPB -3.25846663863766 2.62018989415003e-112 1.33157051171149 2.63433844475182e-53 miRanda -0.249919112437962 1.71731218095656e-43 NA NA NA hsa-miR-139-5p SNRPE -3.25846663863766 2.62018989415003e-112 1.05197039403056 9.03730425534986e-42 miRanda -0.226658110488826 4.52956568579454e-46 NA NA NA hsa-miR-200b-3p SNTB2 2.11744072703209 1.66710572104191e-43 -1.09399922860579 1.22882299797836e-47 TargetScan -0.215770115836527 1.04389500756081e-40 NA NA NA hsa-miR-429 SNTB2 2.84108892259147 3.88520896426515e-64 -1.09399922860579 1.22882299797836e-47 PITA;miRNATAP -0.19448980676552 1.57145832739986e-41 NA NA NA hsa-miR-429 SNURF 2.84108892259147 3.88520896426515e-64 -0.252827386272411 0.262774886061011 PITA;miRanda -0.10845475040122 0.0112187516180514 NA NA NA hsa-miR-183-5p SNX1 2.95681814393872 1.09965777344285e-92 -0.710861147287206 2.25228785596299e-30 MirTarget -0.12068427679955 8.55396074513851e-20 NA NA NA hsa-miR-21-5p SNX1 2.32007501846389 3.08394781855554e-137 -0.710861147287206 2.25228785596299e-30 mirMAP -0.238721111526076 1.72689774002533e-35 NA NA NA hsa-miR-141-3p SNX18 2.99777540204168 1.26370498493024e-78 -0.742505550345305 2.89782251442901e-29 TargetScan -0.142719409232118 1.24677957306499e-28 NA NA NA hsa-miR-141-5p SNX18 2.38411349683216 4.56310582620282e-58 -0.742505550345305 2.89782251442901e-29 miRNATAP -0.118290040388227 2.55500650603338e-16 NA NA NA hsa-miR-200b-3p SNX18 2.11744072703209 1.66710572104191e-43 -0.742505550345305 2.89782251442901e-29 mirMAP -0.140858096153939 2.03794537861157e-23 NA NA NA hsa-miR-429 SNX18 2.84108892259147 3.88520896426515e-64 -0.742505550345305 2.89782251442901e-29 miRNATAP -0.133067999846333 3.40341290372561e-26 NA NA NA hsa-miR-486-5p SNX22 -3.87258704301474 1.22658629378451e-80 0.997879913452147 3.03547427870964e-18 miRanda -0.103197708904925 4.87860700317588e-09 NA NA NA hsa-miR-182-5p SNX29 2.36408084103818 2.60011457600281e-72 -0.597111512317845 3.97672045101413e-19 mirMAP -0.119215362249693 1.01889470076622e-13 NA NA NA hsa-miR-21-5p SNX29 2.32007501846389 3.08394781855554e-137 -0.597111512317845 3.97672045101413e-19 miRNATAP -0.137993773168834 5.43402751369132e-11 NA NA NA hsa-miR-96-5p SNX29 3.24596558166606 1.92296159041707e-98 -0.597111512317845 3.97672045101413e-19 TargetScan -0.146975832858507 1.53315227845282e-29 NA NA NA hsa-miR-21-5p SNX30 2.32007501846389 3.08394781855554e-137 -0.178160894505158 0.0159555391470535 miRNAWalker2_validate -0.103936225222875 5.88654906513536e-06 NA NA NA hsa-miR-141-3p SOBP 2.99777540204168 1.26370498493024e-78 -1.92250565079978 3.14084346276233e-47 MirTarget;TargetScan -0.419182697707988 7.15340806178977e-61 NA NA NA hsa-miR-200a-3p SOBP 2.55218480823434 2.96135446816238e-51 -1.92250565079978 3.14084346276233e-47 MirTarget -0.357577180834894 1.2988364897917e-44 NA NA NA hsa-miR-429 SOCS2 2.84108892259147 3.88520896426515e-64 -1.85803882323019 1.27461377734762e-27 miRNATAP -0.310745479572776 1.65061889897108e-21 NA NA NA hsa-miR-141-3p SOCS5 2.99777540204168 1.26370498493024e-78 -0.851523736382883 3.15353102501472e-34 TargetScan -0.114841074509222 1.33359357804587e-16 NA NA NA hsa-miR-21-5p SOCS5 2.32007501846389 3.08394781855554e-137 -0.851523736382883 3.15353102501472e-34 miRNAWalker2_validate -0.252298585835556 7.63709510228412e-31 NA NA NA hsa-miR-429 SOCS5 2.84108892259147 3.88520896426515e-64 -0.851523736382883 3.15353102501472e-34 miRanda -0.105156285793856 8.96506825888405e-15 NA NA NA hsa-miR-96-5p SOCS7 3.24596558166606 1.92296159041707e-98 -0.880052915807183 2.43072924055549e-10 TargetScan -0.115765157011558 2.92871573800537e-05 NA NA NA hsa-miR-139-5p SOD1 -3.25846663863766 2.62018989415003e-112 0.439566107804334 4.81947664789987e-09 miRanda -0.108063868303499 2.20441092679253e-12 NA NA NA hsa-miR-429 SOD2 2.84108892259147 3.88520896426515e-64 -0.966994178278512 3.78628627013238e-19 miRanda -0.109727127681173 1.35501580568662e-07 NA NA NA hsa-miR-21-5p SOD3 2.32007501846389 3.08394781855554e-137 -2.658433816252 9.8267493618625e-47 miRNAWalker2_validate;miRTarBase -0.541158204506034 1.67623518096689e-19 NA NA NA hsa-miR-429 SORBS1 2.84108892259147 3.88520896426515e-64 -3.50225138578409 2.05072701787994e-102 miRNATAP -0.488530405747879 2.05274370345178e-49 NA NA NA hsa-miR-141-3p SORBS2 2.99777540204168 1.26370498493024e-78 -1.55748312245062 1.12771049723563e-18 MirTarget;TargetScan -0.14745082012242 2.49637988980632e-05 NA NA NA hsa-miR-21-3p SORCS1 2.17476065946878 5.15299442583591e-75 -1.17464209650385 0.00185228663810649 MirTarget -0.520310399266077 1.46958453787038e-07 NA NA NA hsa-miR-429 SORCS1 2.84108892259147 3.88520896426515e-64 -1.17464209650385 0.00185228663810649 miRNATAP -0.265994896748772 0.000199638790861031 NA NA NA hsa-miR-182-5p SOS1 2.36408084103818 2.60011457600281e-72 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.133258609259375 1.37594627633909e-13 NA NA NA hsa-miR-429 SOS1 2.84108892259147 3.88520896426515e-64 -0.877855751541721 1.03695500778597e-32 miRanda;miRNATAP -0.114619423820961 9.86568637608249e-16 NA NA NA hsa-miR-96-5p SOS1 3.24596558166606 1.92296159041707e-98 -0.877855751541721 1.03695500778597e-32 TargetScan;miRNATAP -0.114957974727393 1.33288008849377e-14 NA NA NA hsa-miR-21-5p SOS2 2.32007501846389 3.08394781855554e-137 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.267389788495656 7.45996997519246e-36 NA NA NA hsa-miR-139-3p SOX11 -3.44089023199323 1.67292890850702e-91 1.93898957713241 1.05695558642746e-11 miRNATAP -0.557412197435151 2.05927477781067e-28 NA NA NA hsa-miR-145-5p SOX11 -2.62703571936687 7.64402900188551e-88 1.93898957713241 1.05695558642746e-11 miRNATAP -0.317617135772699 2.00863161539626e-06 NA NA NA hsa-miR-486-5p SOX12 -3.87258704301474 1.22658629378451e-80 1.83982761471753 2.43659100122989e-67 miRNATAP -0.224165655073855 4.03733887739653e-41 NA NA NA hsa-miR-511-5p SOX12 -2.27545475897362 3.84085514050558e-36 1.83982761471753 2.43659100122989e-67 MirTarget -0.282231056845905 9.856206680707e-46 NA NA NA hsa-miR-141-3p SOX17 2.99777540204168 1.26370498493024e-78 -2.06470834363699 3.08106763405428e-53 TargetScan -0.426856956954328 5.06746881736312e-61 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-330-5p SOX17 0.626063225953928 3.42215028606779e-09 -2.06470834363699 3.08106763405428e-53 miRanda -0.461434964169255 9.94438298481541e-25 NA NA NA hsa-miR-590-3p SOX17 1.27438512890514 1.03164723481469e-23 -2.06470834363699 3.08106763405428e-53 miRanda;miRNATAP -0.437832269833539 1.45583399447421e-30 NA NA NA hsa-miR-590-5p SOX17 0.746515607868274 8.51300479640125e-09 -2.06470834363699 3.08106763405428e-53 miRanda -0.386693548488825 4.68900931678905e-26 NA NA NA hsa-miR-139-5p SOX2 -3.25846663863766 2.62018989415003e-112 1.62824878642595 1.83270623627945e-06 miRanda -0.218839977585125 0.00195260988534193 NA NA NA hsa-miR-145-5p SOX2 -2.62703571936687 7.64402900188551e-88 1.62824878642595 1.83270623627945e-06 miRNAWalker2_validate;miRTarBase -0.406343012519686 3.02930538603098e-07 20382729;21211035;22098779;25951106;22835608 Finally we provide evidence that EWS-FLI-1 and miRNA-145 function in a mutually repressive feedback loop and identify their common target gene SOX2 in addition to miRNA145 itself as key players in ESFT cell differentiation and tumorigenicity;We also show that miR-145 and SOX2 form a double negative feedback loop in GBM cells potentially creating a bistable system in GBM cells;In this study our miRNA/mRNA-microarray and RT-PCR analysis showed that the expression of miR145 a tumor-suppressive miRNA is inversely correlated with the levels of Oct4 and Sox2 in GBM-CD133+ cells and malignant glioma specimens; We demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133+;Overexpression of miR 145 5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression; We proposed that miR-145-5p being an important regulator of SOX2 carries a crucial role in PCa tumorigenesis;miR-145 regulates SOX2 and OCT4 translation and p53 regulates miR-145 expression differentiation;;malignant trasformation;tumorigenesis;tumorigenesis; sarcoma;glioblastoma;glioblastoma;prostate cancer;lung squamous cell cancer hsa-miR-486-5p SOX2 -3.87258704301474 1.22658629378451e-80 1.62824878642595 1.83270623627945e-06 miRanda -0.165278281469295 0.00152309022494884 NA NA NA hsa-miR-139-3p SOX4 -3.44089023199323 1.67292890850702e-91 0.859130686453574 1.16702184409823e-20 miRNATAP -0.175209369874522 2.78943871692074e-26 NA NA NA hsa-miR-145-5p SOX4 -2.62703571936687 7.64402900188551e-88 0.859130686453574 1.16702184409823e-20 mirMAP -0.123552117862411 1.39171106844286e-08 NA NA NA hsa-miR-335-5p SOX4 -2.61355235628987 2.6462884165886e-51 0.859130686453574 1.16702184409823e-20 miRNAWalker2_validate;miRTarBase -0.10159640696189 5.28590619061679e-09 22034498 Both TCDD and MCDF induced miR-335 in MDA-MB-231 and BT474 cells and this was accompanied by downregulation of SOX4 a miR-335-regulated inhibited gene breast cancer hsa-miR-141-3p SOX5 2.99777540204168 1.26370498493024e-78 -2.72079957365634 5.8401556767149e-39 TargetScan;miRNATAP -0.430365301520418 1.99260254061188e-25 NA NA NA hsa-miR-182-5p SOX5 2.36408084103818 2.60011457600281e-72 -2.72079957365634 5.8401556767149e-39 miRNATAP -0.442440850447799 4.95482795722056e-18 NA NA NA hsa-miR-200a-3p SOX5 2.55218480823434 2.96135446816238e-51 -2.72079957365634 5.8401556767149e-39 miRNATAP -0.351484208239173 8.90274583859572e-18 NA NA NA hsa-miR-200b-3p SOX5 2.11744072703209 1.66710572104191e-43 -2.72079957365634 5.8401556767149e-39 TargetScan -0.364876125408741 1.32814580150601e-15 NA NA NA hsa-miR-21-5p SOX5 2.32007501846389 3.08394781855554e-137 -2.72079957365634 5.8401556767149e-39 miRNAWalker2_validate;miRTarBase;miRNATAP -0.756030812927406 1.40346547972103e-30 NA NA NA hsa-miR-429 SOX5 2.84108892259147 3.88520896426515e-64 -2.72079957365634 5.8401556767149e-39 miRNATAP -0.400671125228919 3.1560801985958e-23 NA NA NA hsa-miR-96-5p SOX5 3.24596558166606 1.92296159041707e-98 -2.72079957365634 5.8401556767149e-39 TargetScan;miRNATAP -0.485248857647561 2.50818465597841e-31 NA NA NA hsa-miR-141-3p SOX6 2.99777540204168 1.26370498493024e-78 -2.37114135592246 4.35252660248189e-25 TargetScan;mirMAP -0.382619685003343 2.10089851129293e-17 NA NA NA hsa-miR-182-5p SOX6 2.36408084103818 2.60011457600281e-72 -2.37114135592246 4.35252660248189e-25 miRNATAP -0.472570897443951 1.17756599469332e-17 NA NA NA hsa-miR-183-5p SOX6 2.95681814393872 1.09965777344285e-92 -2.37114135592246 4.35252660248189e-25 miRNATAP -0.405718930546266 1.09324874890248e-16 NA NA NA hsa-miR-200a-3p SOX6 2.55218480823434 2.96135446816238e-51 -2.37114135592246 4.35252660248189e-25 mirMAP -0.307739545490966 4.87593377452818e-12 NA NA NA hsa-miR-200b-3p SOX6 2.11744072703209 1.66710572104191e-43 -2.37114135592246 4.35252660248189e-25 TargetScan;mirMAP -0.317329860053222 1.6298235759825e-10 NA NA NA hsa-miR-200c-3p SOX6 2.07038651806183 6.84613386286599e-51 -2.37114135592246 4.35252660248189e-25 mirMAP;miRNATAP -0.413608366364795 2.62937915332749e-14 NA NA NA hsa-miR-21-5p SOX6 2.32007501846389 3.08394781855554e-137 -2.37114135592246 4.35252660248189e-25 MirTarget;miRNATAP -0.614523344099219 1.85455711268023e-17 NA NA NA hsa-miR-375 SOX6 2.09893673049766 1.68351780396203e-16 -2.37114135592246 4.35252660248189e-25 miRNATAP -0.364631576525398 3.54004658715036e-34 NA NA NA hsa-miR-429 SOX6 2.84108892259147 3.88520896426515e-64 -2.37114135592246 4.35252660248189e-25 miRNATAP -0.273837104367138 6.71329659949733e-10 NA NA NA hsa-miR-96-5p SOX6 3.24596558166606 1.92296159041707e-98 -2.37114135592246 4.35252660248189e-25 MirTarget;TargetScan;miRNATAP -0.381806192555579 8.74349870131693e-17 NA NA NA hsa-miR-21-5p SOX7 2.32007501846389 3.08394781855554e-137 -2.03763714116017 7.48936355365806e-59 miRNATAP -0.469582240491516 1.09791134352581e-30 NA NA NA hsa-miR-21-5p SP1 2.32007501846389 3.08394781855554e-137 -0.354351925158745 1.46585727332836e-11 miRNAWalker2_validate;miRTarBase -0.155768447861795 3.88544448292272e-22 NA NA NA hsa-miR-21-3p SP4 2.17476065946878 5.15299442583591e-75 -0.714864283151224 1.86226309006362e-13 MirTarget -0.104840195287448 5.09720858623432e-05 NA NA NA hsa-miR-139-5p SPA17 -3.25846663863766 2.62018989415003e-112 0.704893498640069 1.61635861775731e-09 mirMAP -0.140347602051501 5.75466485484652e-09 NA NA NA hsa-miR-139-5p SPAG1 -3.25846663863766 2.62018989415003e-112 1.21536502852341 1.21867718052225e-27 miRanda -0.220857616903787 1.5645118124661e-21 NA NA NA hsa-miR-511-5p SPAG17 -2.27545475897362 3.84085514050558e-36 -0.488219136381446 0.125930233007451 MirTarget -0.1374923345888 0.0180140468722284 NA NA NA hsa-miR-141-3p SPAG9 2.99777540204168 1.26370498493024e-78 -0.551286921853523 5.94847160665692e-12 MirTarget;TargetScan;miRNATAP -0.124232034172895 1.10613748412868e-15 26790956 SPAG9 and miR-141 expression were detected in HCC tissues and cell lines by Western blot and real-time PCR; Dual-luciferase reporter assay was utilized to validate SPAG9 as a direct target gene of miR-141; An inverse correlation was observed between SPAG9 and miR-141 expression in HCC tissues and cell lines; Dual-luciferase reporter assay further showed that SPAG9 was a direct target gene of miR-141; The ectopic expression of miR-141 could markedly suppress SPAG9 expression in HCC cells; MiR-141 overexpression also resulted in significantly reduced cell proliferation invasion and migration and imitation of the SPAG9 knockdown effects on HCC cells; Furthermore SPAG9 restoration in miR-141-expressing cells sufficiently attenuated the tumor-suppressive effects of miR-141; Finally JNK activity was found to be reduced by miR-141 overexpression the same way as by SPAG9 silencing; MiR-141 suppression may cause aberrant expression of SPAG9 and promote HCC tumorigenesis via JNK pathway tumorigenesis liver cancer hsa-miR-182-5p SPAG9 2.36408084103818 2.60011457600281e-72 -0.551286921853523 5.94847160665692e-12 MirTarget -0.122708896147576 1.41441508013536e-10 NA NA NA hsa-miR-200a-3p SPAG9 2.55218480823434 2.96135446816238e-51 -0.551286921853523 5.94847160665692e-12 MirTarget;miRNATAP -0.133325885170975 1.35903070345216e-18 26797273 MicroRNA 200a 3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma; Our study tried to explore the mediator of miR-200a-3p a tumor suppressing miRNA on SPAG9 expression and renal cell proliferation and apoptosis; In addition our study uncovered that miR-200a-3p directly regulates oncogenic SPAG9 in 786-O and ACHN cells; Understanding of oncogenic SPAG9 regulated by miR-200a-3p might be beneficial to reveal new therapeutic targets for RCC kidney renal cell cancer hsa-miR-200b-3p SPAG9 2.11744072703209 1.66710572104191e-43 -0.551286921853523 5.94847160665692e-12 MirTarget;TargetScan -0.146710934379247 3.23809849372727e-18 NA NA NA hsa-miR-200c-3p SPAG9 2.07038651806183 6.84613386286599e-51 -0.551286921853523 5.94847160665692e-12 MirTarget;miRNATAP -0.146454226449591 3.58899801462239e-15 NA NA NA hsa-miR-429 SPAG9 2.84108892259147 3.88520896426515e-64 -0.551286921853523 5.94847160665692e-12 MirTarget;miRanda;miRNATAP -0.127515666952229 2.66274280371012e-17 NA NA NA hsa-miR-139-5p SPATA17 -3.25846663863766 2.62018989415003e-112 2.04327922802146 6.488357648884e-39 miRanda -0.346313758285166 5.19570164166908e-26 NA NA NA hsa-miR-21-5p SPATA18 2.32007501846389 3.08394781855554e-137 -1.44815003497786 1.71037750364847e-15 mirMAP -0.509548577055583 1.87759596675863e-19 NA NA NA hsa-miR-145-5p SPATS2 -2.62703571936687 7.64402900188551e-88 0.846399001925744 1.6430729270988e-46 MirTarget -0.158918942612411 8.89890005924841e-30 NA NA NA hsa-miR-139-5p SPCS2 -3.25846663863766 2.62018989415003e-112 0.635242061441303 9.86404468355585e-18 miRanda -0.109674123440059 8.99425714555509e-13 NA NA NA hsa-miR-335-5p SPDEF -2.61355235628987 2.6462884165886e-51 2.00809080308135 2.85061195349609e-11 miRNAWalker2_validate -0.150110305577441 0.00820090396719723 NA NA NA hsa-miR-21-5p SPG11 2.32007501846389 3.08394781855554e-137 -0.238158321041959 0.00209839306668128 miRNAWalker2_validate -0.146560576949795 9.20747133839781e-10 NA NA NA hsa-miR-200b-3p SPG20 2.11744072703209 1.66710572104191e-43 -1.1412579469464 6.97839818554614e-36 TargetScan -0.155589883361788 5.54240779007804e-15 NA NA NA hsa-miR-21-5p SPG20 2.32007501846389 3.08394781855554e-137 -1.1412579469464 6.97839818554614e-36 miRNATAP -0.373777345855725 8.83147806164101e-40 NA NA NA hsa-miR-429 SPG20 2.84108892259147 3.88520896426515e-64 -1.1412579469464 6.97839818554614e-36 miRanda;miRNATAP -0.161648851416547 5.6058851136867e-20 NA NA NA hsa-miR-183-5p SPN 2.95681814393872 1.09965777344285e-92 0.0101792377906609 0.943004960884371 mirMAP -0.111107228534746 0.000204815571567989 NA NA NA hsa-miR-429 SPOCK1 2.84108892259147 3.88520896426515e-64 0.314214907825931 0.0640142664939813 miRNATAP -0.172376870667441 6.78229635149319e-08 NA NA NA hsa-miR-375 SPOCK3 2.09893673049766 1.68351780396203e-16 -2.9791873535921 4.19634385238139e-30 miRanda -0.15981451400541 7.35569684192794e-06 NA NA NA hsa-miR-224-5p SPOPL -2.22249420723892 1.07787949391113e-18 0.220138177694735 0.0251836057993066 MirTarget -0.122502702086306 7.89758233400106e-22 NA NA NA hsa-miR-452-5p SPOPL -2.48486455572568 1.24430987974325e-33 0.220138177694735 0.0251836057993066 mirMAP -0.173385622119362 2.74524545779626e-30 NA NA NA hsa-miR-139-5p SPP1 -3.25846663863766 2.62018989415003e-112 2.26670631164277 1.22530665713086e-25 miRanda -0.500352860676903 2.02284408020613e-29 NA NA NA hsa-miR-335-5p SPP1 -2.61355235628987 2.6462884165886e-51 2.26670631164277 1.22530665713086e-25 miRNAWalker2_validate -0.324190847145869 2.06671050183243e-15 NA NA NA hsa-miR-141-3p SPRED1 2.99777540204168 1.26370498493024e-78 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.161162915971162 2.35918858864777e-19 NA NA NA hsa-miR-183-5p SPRED1 2.95681814393872 1.09965777344285e-92 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.175824540066669 1.36831923795005e-19 NA NA NA hsa-miR-200a-3p SPRED1 2.55218480823434 2.96135446816238e-51 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.131532261379301 1.11338813569557e-13 NA NA NA hsa-miR-200b-3p SPRED1 2.11744072703209 1.66710572104191e-43 -0.73987992932487 1.32055673934219e-15 TargetScan -0.142284251884432 5.32725114828085e-13 NA NA NA hsa-miR-200c-3p SPRED1 2.07038651806183 6.84613386286599e-51 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.191613645318991 5.16049176566749e-19 NA NA NA hsa-miR-429 SPRED1 2.84108892259147 3.88520896426515e-64 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.134717920033516 1.76188718637229e-14 NA NA NA hsa-miR-335-5p SPRR3 -2.61355235628987 2.6462884165886e-51 1.42893383780681 1.61881911188858e-06 miRNAWalker2_validate -0.197071497312506 0.000395143621808804 NA NA NA hsa-miR-21-5p SPRY1 2.32007501846389 3.08394781855554e-137 -2.02456512680151 4.17071179941854e-56 miRNATAP -0.446564917887034 6.78372597097293e-27 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-21-5p SPRY2 2.32007501846389 3.08394781855554e-137 -2.72906279183225 4.36360171627142e-90 miRNAWalker2_validate;miRTarBase;miRNATAP -0.684722889689909 7.12948810098069e-54 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-429 SPRY2 2.84108892259147 3.88520896426515e-64 -2.72906279183225 4.36360171627142e-90 miRanda -0.370395879934324 8.88044596656627e-42 NA NA NA hsa-miR-141-3p SPRY3 2.99777540204168 1.26370498493024e-78 -0.743897577510337 8.22794586143845e-18 mirMAP -0.108375435062231 1.80222465712053e-10 NA NA NA hsa-miR-182-5p SPRY3 2.36408084103818 2.60011457600281e-72 -0.743897577510337 8.22794586143845e-18 mirMAP -0.139048934279916 2.34503167156917e-11 NA NA NA hsa-miR-200a-3p SPRY3 2.55218480823434 2.96135446816238e-51 -0.743897577510337 8.22794586143845e-18 mirMAP -0.106245731360012 1.86180122777501e-10 NA NA NA hsa-miR-200b-3p SPRY3 2.11744072703209 1.66710572104191e-43 -0.743897577510337 8.22794586143845e-18 mirMAP -0.116765535305546 3.07731809687366e-10 NA NA NA hsa-miR-200c-3p SPRY3 2.07038651806183 6.84613386286599e-51 -0.743897577510337 8.22794586143845e-18 mirMAP -0.127854270188269 3.67091697628272e-10 NA NA NA hsa-miR-21-3p SPRY3 2.17476065946878 5.15299442583591e-75 -0.743897577510337 8.22794586143845e-18 mirMAP -0.102159363784401 1.02696914909014e-05 NA NA NA hsa-miR-96-5p SPRY3 3.24596558166606 1.92296159041707e-98 -0.743897577510337 8.22794586143845e-18 MirTarget;TargetScan -0.112857949131037 6.43649140897643e-11 NA NA NA hsa-miR-141-3p SPRY4 2.99777540204168 1.26370498493024e-78 -0.269797609928706 0.00344671028336406 TargetScan;miRNATAP -0.136262756960658 1.26981399486428e-14 NA NA NA hsa-miR-200a-3p SPRY4 2.55218480823434 2.96135446816238e-51 -0.269797609928706 0.00344671028336406 mirMAP;miRNATAP -0.135104834299242 6.51393438180949e-15 NA NA NA hsa-miR-429 SPRY4 2.84108892259147 3.88520896426515e-64 -0.269797609928706 0.00344671028336406 miRanda -0.124670922388077 5.08890882170263e-13 NA NA NA hsa-miR-96-5p SPSB1 3.24596558166606 1.92296159041707e-98 -0.153869799846705 0.120022872984067 MirTarget;TargetScan -0.126668505360087 5.92723261737777e-11 NA NA NA hsa-miR-429 SPTB 2.84108892259147 3.88520896426515e-64 -1.47814591803123 1.64186103159542e-30 miRNATAP -0.170829994743712 8.75386755497543e-12 NA NA NA hsa-miR-183-5p SPTBN1 2.95681814393872 1.09965777344285e-92 -1.9362598712969 2.27075223607576e-99 miRNATAP -0.285471665332673 3.72555313873663e-43 NA NA NA hsa-miR-429 SPTBN1 2.84108892259147 3.88520896426515e-64 -1.9362598712969 2.27075223607576e-99 PITA;miRanda -0.255244390904648 1.12964494747244e-42 NA NA NA hsa-miR-335-5p SPTBN2 -2.61355235628987 2.6462884165886e-51 1.00565971553753 9.5999344694223e-09 miRNAWalker2_validate -0.179475574013128 3.81421594704398e-08 NA NA NA hsa-miR-21-5p SPTLC3 2.32007501846389 3.08394781855554e-137 -0.682667190462722 7.9335195772047e-07 miRNAWalker2_validate -0.14825479670126 0.000620543662309423 NA NA NA hsa-miR-335-5p SQLE -2.61355235628987 2.6462884165886e-51 2.16459715549362 9.10365087048885e-58 miRNAWalker2_validate -0.227532899232031 8.50677062478867e-18 NA NA NA hsa-miR-378a-5p SRCIN1 -2.43173551693523 1.44932837789175e-68 1.01769401933761 6.04876320869876e-10 mirMAP -0.489406504260048 9.14064151944639e-43 NA NA NA hsa-miR-452-5p SRCIN1 -2.48486455572568 1.24430987974325e-33 1.01769401933761 6.04876320869876e-10 MirTarget -0.246740769466645 1.72555021557871e-21 NA NA NA hsa-miR-145-5p SRD5A2 -2.62703571936687 7.64402900188551e-88 1.69756588590754 3.36235577298704e-15 MirTarget -0.159499147767344 0.00173482769317921 NA NA NA hsa-miR-139-5p SRD5A3 -3.25846663863766 2.62018989415003e-112 0.831169173355671 1.91696796772583e-18 miRanda -0.155479001372582 2.30102097695458e-15 NA NA NA hsa-miR-335-5p SREBF1 -2.61355235628987 2.6462884165886e-51 1.02256857004088 9.67426146601142e-16 miRNAWalker2_validate -0.143120209649718 2.06262254602238e-09 NA NA NA hsa-miR-486-5p SREBF1 -3.87258704301474 1.22658629378451e-80 1.02256857004088 9.67426146601142e-16 miRanda -0.108514136292454 2.89159676933741e-08 NA NA NA hsa-miR-10b-5p SREBF2 -2.10996264627796 7.36811595736367e-72 0.216271075133831 0.00628282508680627 mirMAP -0.108528405958555 2.29204978843082e-07 NA NA NA hsa-miR-452-5p SRP54 -2.48486455572568 1.24430987974325e-33 0.593964192103022 6.0275181510281e-22 MirTarget;miRNATAP -0.1046370750481 1.13419406235669e-26 NA NA NA hsa-miR-99a-5p SRPK1 -2.25079447371102 1.14086813185885e-54 0.760652428998505 3.02753320158355e-19 miRNAWalker2_validate -0.143765011413637 3.00997519936841e-14 NA NA NA hsa-miR-335-5p SRPK3 -2.61355235628987 2.6462884165886e-51 1.22686922041476 3.63810428736009e-07 miRNAWalker2_validate -0.196682196161323 1.22159259217455e-05 NA NA NA hsa-miR-139-5p SRPRB -3.25846663863766 2.62018989415003e-112 0.770164102521342 3.65282649964317e-33 miRanda -0.166807464119499 6.4847489921515e-37 NA NA NA hsa-miR-486-5p SRRM5 -3.87258704301474 1.22658629378451e-80 0.872097982628275 7.91385022152637e-25 miRanda -0.117275288833502 1.56782017155067e-19 NA NA NA hsa-miR-21-5p SSFA2 2.32007501846389 3.08394781855554e-137 -0.561420910048069 2.15417805533345e-05 miRNAWalker2_validate;miRNATAP -0.297126225518918 3.37386167687646e-13 NA NA NA hsa-miR-200c-3p SSH2 2.07038651806183 6.84613386286599e-51 -0.339977737557532 0.000104804788074283 miRNATAP -0.14112426863106 3.20663257982363e-12 NA NA NA hsa-miR-429 SSH2 2.84108892259147 3.88520896426515e-64 -0.339977737557532 0.000104804788074283 PITA;miRanda;miRNATAP -0.106730802692908 9.33996009452441e-11 NA NA NA hsa-miR-21-3p SSPN 2.17476065946878 5.15299442583591e-75 -1.93670652602899 2.44085534149322e-61 MirTarget -0.289034730901701 8.58071455852396e-19 NA NA NA hsa-miR-141-3p SSTR1 2.99777540204168 1.26370498493024e-78 -3.37367224819205 2.06078044997098e-50 mirMAP -0.622198652649971 8.64842741773479e-45 NA NA NA hsa-miR-200a-3p SSTR1 2.55218480823434 2.96135446816238e-51 -3.37367224819205 2.06078044997098e-50 mirMAP -0.500478170759875 1.56875067366482e-29 NA NA NA hsa-miR-139-5p SSX2IP -3.25846663863766 2.62018989415003e-112 1.30480322687109 2.1974657915531e-49 MirTarget;PITA;miRanda;miRNATAP -0.268765793299292 2.15368950690273e-49 NA NA NA hsa-miR-337-3p SSX2IP -2.14274617598363 2.70942896809734e-43 1.30480322687109 2.1974657915531e-49 mirMAP -0.121413303246376 4.41359246940611e-10 NA NA NA hsa-miR-335-5p ST14 -2.61355235628987 2.6462884165886e-51 1.47304094992251 1.76339819345695e-33 miRNAWalker2_validate -0.260017128167008 4.52901013488531e-30 NA NA NA hsa-miR-200b-3p ST3GAL2 2.11744072703209 1.66710572104191e-43 -0.172671109983257 0.0320901924647913 MirTarget;TargetScan -0.153045431167801 4.96856440917504e-20 NA NA NA hsa-miR-200c-3p ST3GAL2 2.07038651806183 6.84613386286599e-51 -0.172671109983257 0.0320901924647913 MirTarget;miRNATAP -0.205857076845866 6.8218272605097e-30 NA NA NA hsa-miR-429 ST3GAL2 2.84108892259147 3.88520896426515e-64 -0.172671109983257 0.0320901924647913 MirTarget;PITA;miRanda;miRNATAP -0.121852860201579 4.33552586959599e-16 NA NA NA hsa-miR-96-5p ST3GAL2 3.24596558166606 1.92296159041707e-98 -0.172671109983257 0.0320901924647913 TargetScan -0.139159586154687 4.29450200811173e-19 NA NA NA hsa-miR-141-3p ST3GAL3 2.99777540204168 1.26370498493024e-78 -0.858146158856265 5.25971005002269e-27 MirTarget;TargetScan;miRNATAP -0.17540419708461 6.94968958273019e-30 NA NA NA hsa-miR-182-5p ST3GAL3 2.36408084103818 2.60011457600281e-72 -0.858146158856265 5.25971005002269e-27 mirMAP -0.15776129457362 2.76115109081008e-16 NA NA NA hsa-miR-200a-3p ST3GAL3 2.55218480823434 2.96135446816238e-51 -0.858146158856265 5.25971005002269e-27 MirTarget;miRNATAP -0.106516924911605 6.72426266181531e-12 NA NA NA hsa-miR-96-5p ST3GAL3 3.24596558166606 1.92296159041707e-98 -0.858146158856265 5.25971005002269e-27 TargetScan;miRNATAP -0.13348016318175 6.74608122710787e-17 NA NA NA hsa-miR-141-3p ST3GAL5 2.99777540204168 1.26370498493024e-78 -0.518926657940599 1.34427760582184e-06 MirTarget;TargetScan -0.164414450467899 1.67797024775632e-15 NA NA NA hsa-miR-200a-3p ST3GAL5 2.55218480823434 2.96135446816238e-51 -0.518926657940599 1.34427760582184e-06 MirTarget -0.15050353403089 1.25005298897729e-13 NA NA NA hsa-miR-429 ST3GAL5 2.84108892259147 3.88520896426515e-64 -0.518926657940599 1.34427760582184e-06 miRanda -0.135934878989975 1.80937864852586e-11 NA NA NA hsa-miR-139-5p ST6GAL2 -3.25846663863766 2.62018989415003e-112 1.15906949574813 1.52522181723685e-09 miRanda -0.246739863648195 4.31052251405714e-10 NA NA NA hsa-miR-141-3p ST6GALNAC3 2.99777540204168 1.26370498493024e-78 -2.13511757496546 6.942886718098e-66 mirMAP -0.389752882216162 6.53349343476067e-57 NA NA NA hsa-miR-182-5p ST6GALNAC3 2.36408084103818 2.60011457600281e-72 -2.13511757496546 6.942886718098e-66 mirMAP -0.370520305587386 6.52482244481251e-33 NA NA NA hsa-miR-183-5p ST6GALNAC3 2.95681814393872 1.09965777344285e-92 -2.13511757496546 6.942886718098e-66 MirTarget -0.382073055635778 1.50462276761619e-45 NA NA NA hsa-miR-200a-3p ST6GALNAC3 2.55218480823434 2.96135446816238e-51 -2.13511757496546 6.942886718098e-66 mirMAP -0.326445365529675 2.95714418473664e-40 NA NA NA hsa-miR-200a-5p ST6GALNAC3 2.58844508672328 1.79650654234569e-56 -2.13511757496546 6.942886718098e-66 MirTarget -0.332564435346887 8.16981374041641e-40 NA NA NA hsa-miR-429 ST6GALNAC3 2.84108892259147 3.88520896426515e-64 -2.13511757496546 6.942886718098e-66 miRanda -0.323590047326446 4.33683479957085e-40 NA NA NA hsa-miR-96-5p ST6GALNAC3 3.24596558166606 1.92296159041707e-98 -2.13511757496546 6.942886718098e-66 MirTarget;TargetScan -0.35370428761221 2.97948792496211e-44 NA NA NA hsa-miR-486-5p ST6GALNAC5 -3.87258704301474 1.22658629378451e-80 0.178416237137439 0.43313173881762 miRanda -0.116846660946116 0.00071381051175041 NA NA NA hsa-miR-429 ST8SIA1 2.84108892259147 3.88520896426515e-64 -1.64415684248008 1.27923231642437e-18 miRNATAP -0.175312735651238 1.09883388814777e-06 NA NA NA hsa-miR-200b-3p ST8SIA2 2.11744072703209 1.66710572104191e-43 -1.82054064267358 1.68353865315065e-12 mirMAP -0.244977760956555 9.38991697162383e-06 NA NA NA hsa-miR-200c-3p ST8SIA2 2.07038651806183 6.84613386286599e-51 -1.82054064267358 1.68353865315065e-12 mirMAP -0.281252408542962 3.68609966901047e-06 NA NA NA hsa-miR-429 ST8SIA2 2.84108892259147 3.88520896426515e-64 -1.82054064267358 1.68353865315065e-12 mirMAP;miRNATAP -0.254728019490482 2.33958691803179e-07 NA NA NA hsa-miR-96-5p ST8SIA2 3.24596558166606 1.92296159041707e-98 -1.82054064267358 1.68353865315065e-12 mirMAP -0.438430998461854 5.33751943467375e-18 NA NA NA hsa-miR-429 STAC 2.84108892259147 3.88520896426515e-64 -2.27936273445557 1.30140970804564e-24 miRanda -0.243849183670341 1.5750212724275e-08 NA NA NA hsa-miR-429 STAC2 2.84108892259147 3.88520896426515e-64 -3.92462248766626 1.69039671507241e-20 miRNATAP -0.380321952194628 3.30424858053874e-06 NA NA NA hsa-miR-96-5p STAG1 3.24596558166606 1.92296159041707e-98 -0.619829084277215 3.83376771553184e-11 TargetScan;miRNATAP -0.10025084146953 7.42338601520624e-08 NA NA NA hsa-miR-21-5p STAG2 2.32007501846389 3.08394781855554e-137 -0.45824296739927 2.14317343940316e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.238585426475483 1.76104366677348e-30 NA NA NA hsa-miR-182-5p STARD13 2.36408084103818 2.60011457600281e-72 -0.854533102709033 1.74673553708564e-17 miRNATAP -0.159470238863479 4.02848221642012e-11 NA NA NA hsa-miR-200b-3p STARD13 2.11744072703209 1.66710572104191e-43 -0.854533102709033 1.74673553708564e-17 TargetScan -0.165110996329142 1.20047359568824e-14 NA NA NA hsa-miR-429 STARD13 2.84108892259147 3.88520896426515e-64 -0.854533102709033 1.74673553708564e-17 PITA;miRanda;miRNATAP -0.185701017828746 8.9073565025986e-23 NA NA NA hsa-miR-200b-3p STARD8 2.11744072703209 1.66710572104191e-43 -1.14973449373513 2.16206820659553e-34 mirMAP -0.269052095440804 2.92934549316219e-42 NA NA NA hsa-miR-200c-3p STARD8 2.07038651806183 6.84613386286599e-51 -1.14973449373513 2.16206820659553e-34 mirMAP -0.340394258716721 1.57053362762849e-57 NA NA NA hsa-miR-429 STARD8 2.84108892259147 3.88520896426515e-64 -1.14973449373513 2.16206820659553e-34 miRanda;mirMAP -0.261679088367001 6.77579616187582e-51 NA NA NA hsa-miR-145-5p STAT1 -2.62703571936687 7.64402900188551e-88 0.84704946611897 1.52503088632031e-12 miRNAWalker2_validate;miRTarBase -0.190431855359047 8.49731192294897e-12 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-141-3p STAT4 2.99777540204168 1.26370498493024e-78 -0.980704169210314 7.75895883125847e-09 MirTarget;TargetScan -0.240950533860277 2.29630203380521e-13 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 2.55218480823434 2.96135446816238e-51 -0.980704169210314 7.75895883125847e-09 MirTarget -0.213924427791527 3.73823510549369e-11 NA NA NA hsa-miR-141-3p STAT5A 2.99777540204168 1.26370498493024e-78 -1.42714993428393 2.70689276768275e-43 MirTarget;TargetScan;miRNATAP -0.249467858863614 1.60720902974445e-34 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-141-5p STAT5A 2.38411349683216 4.56310582620282e-58 -1.42714993428393 2.70689276768275e-43 MirTarget -0.274131311316507 3.92901446864404e-34 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-200a-3p STAT5A 2.55218480823434 2.96135446816238e-51 -1.42714993428393 2.70689276768275e-43 MirTarget;miRNATAP -0.17649399523056 5.36082676998248e-18 NA NA NA hsa-miR-141-3p STAT5B 2.99777540204168 1.26370498493024e-78 -1.26603570026736 3.18742679965819e-62 MirTarget;TargetScan;miRNATAP -0.210194932545999 8.1601418441609e-44 NA NA NA hsa-miR-200a-3p STAT5B 2.55218480823434 2.96135446816238e-51 -1.26603570026736 3.18742679965819e-62 MirTarget;miRNATAP -0.166364658066859 5.40700398258099e-28 NA NA NA hsa-miR-21-3p STAT5B 2.17476065946878 5.15299442583591e-75 -1.26603570026736 3.18742679965819e-62 MirTarget -0.265425490688425 9.56942391027435e-38 NA NA NA hsa-miR-139-5p STAU2 -3.25846663863766 2.62018989415003e-112 0.340524412819404 1.99532757393887e-05 miRanda -0.115132957737541 1.55271272877322e-12 NA NA NA hsa-miR-452-5p STC1 -2.48486455572568 1.24430987974325e-33 0.0174437759200483 0.927534883709258 miRNATAP -0.133915237267937 1.15039796540307e-05 NA NA NA hsa-miR-141-3p STEAP2 2.99777540204168 1.26370498493024e-78 -1.11890369934626 3.76224373550894e-10 MirTarget;miRNATAP -0.205997200933082 3.30030033233962e-09 NA NA NA hsa-miR-200a-3p STEAP2 2.55218480823434 2.96135446816238e-51 -1.11890369934626 3.76224373550894e-10 MirTarget;miRNATAP -0.159119364463283 3.49657847105165e-06 NA NA NA hsa-miR-429 STEAP4 2.84108892259147 3.88520896426515e-64 -2.11022162821069 4.55525859088871e-19 miRanda -0.339511680597531 5.66370941658154e-14 NA NA NA hsa-miR-139-5p STIL -3.25846663863766 2.62018989415003e-112 1.89146551845257 3.01205290341801e-46 miRanda -0.41751502206563 8.54103084670571e-54 NA NA NA hsa-miR-183-5p STIM2 2.95681814393872 1.09965777344285e-92 -0.534429431625996 2.55260850026432e-21 miRNATAP -0.101836706693309 1.33216680920822e-17 NA NA NA hsa-miR-182-5p STK17A 2.36408084103818 2.60011457600281e-72 -0.265091362289759 0.000363583881688797 miRNATAP -0.105671373926308 1.90739438031831e-09 NA NA NA hsa-miR-182-5p STK17B 2.36408084103818 2.60011457600281e-72 -0.486632796300338 3.89752901656069e-07 miRNATAP -0.192102382916102 1.65695237852444e-17 NA NA NA hsa-miR-429 STK17B 2.84108892259147 3.88520896426515e-64 -0.486632796300338 3.89752901656069e-07 miRanda -0.116063503318712 1.42488532920969e-10 NA NA NA hsa-miR-96-5p STK17B 3.24596558166606 1.92296159041707e-98 -0.486632796300338 3.89752901656069e-07 TargetScan;miRNATAP -0.16246512242442 3.71584662574467e-18 NA NA NA hsa-miR-183-5p STK33 2.95681814393872 1.09965777344285e-92 -0.370617566180984 0.088698248281685 miRNAWalker2_validate -0.191443453328337 2.86816460455611e-05 NA NA NA hsa-miR-21-5p STK40 2.32007501846389 3.08394781855554e-137 -0.360125735975328 5.45036023427364e-09 MirTarget;miRNATAP -0.124884333810775 7.46670904029131e-11 NA NA NA hsa-miR-139-5p STMN1 -3.25846663863766 2.62018989415003e-112 1.51200856817845 5.00282620356561e-37 miRanda -0.33498087386875 3.46506333135609e-43 NA NA NA hsa-miR-96-5p STMN2 3.24596558166606 1.92296159041707e-98 -0.205299959363472 0.320362262576957 MirTarget;TargetScan -0.110765498870763 0.00668006494149603 NA NA NA hsa-miR-375 STON1 2.09893673049766 1.68351780396203e-16 -1.5979483127904 5.46305194597446e-37 miRanda -0.190618004671118 5.64382290590757e-30 NA NA NA hsa-miR-182-5p STOX2 2.36408084103818 2.60011457600281e-72 -2.17785813438514 8.62614488923023e-30 MirTarget -0.46300166859947 1.27922911619505e-23 NA NA NA hsa-miR-429 STOX2 2.84108892259147 3.88520896426515e-64 -2.17785813438514 8.62614488923023e-30 miRanda -0.259929583103679 3.19925343765822e-12 NA NA NA hsa-miR-96-5p STOX2 3.24596558166606 1.92296159041707e-98 -2.17785813438514 8.62614488923023e-30 TargetScan -0.38488812036155 1.04557222996217e-23 NA NA NA hsa-miR-486-5p STRA6 -3.87258704301474 1.22658629378451e-80 2.47262448354135 1.33729074383153e-44 miRanda -0.338525801137414 1.20796643477966e-35 NA NA NA hsa-miR-429 STRADB 2.84108892259147 3.88520896426515e-64 -0.643341720695693 4.11123485334864e-15 miRanda -0.122365922894823 3.19732126795465e-15 NA NA NA hsa-miR-139-5p STRBP -3.25846663863766 2.62018989415003e-112 1.15940175513552 1.69414117013682e-52 miRanda;mirMAP -0.221569702333243 1.36777172118168e-44 NA NA NA hsa-miR-375 STX11 2.09893673049766 1.68351780396203e-16 -1.90080834713827 1.4956408342951e-50 miRanda -0.193274839875399 4.26229203092568e-29 NA NA NA hsa-miR-335-5p STX1A -2.61355235628987 2.6462884165886e-51 1.57261944326317 3.66317167496333e-44 miRNAWalker2_validate -0.168241731601848 1.22666522883261e-14 NA NA NA hsa-miR-182-5p STX1B 2.36408084103818 2.60011457600281e-72 -0.750600392365291 3.51549659031347e-07 mirMAP -0.113811491397658 0.00127371794226222 NA NA NA hsa-miR-183-5p STX1B 2.95681814393872 1.09965777344285e-92 -0.750600392365291 3.51549659031347e-07 mirMAP -0.234818328886263 2.49016095387062e-14 NA NA NA hsa-miR-21-3p STX1B 2.17476065946878 5.15299442583591e-75 -0.750600392365291 3.51549659031347e-07 mirMAP -0.291194903185799 3.87452925825006e-14 NA NA NA hsa-miR-429 STX1B 2.84108892259147 3.88520896426515e-64 -0.750600392365291 3.51549659031347e-07 miRNATAP -0.140199040963008 5.31298093259012e-07 NA NA NA hsa-miR-141-3p STX2 2.99777540204168 1.26370498493024e-78 -0.477957124111536 3.91337532111255e-12 MirTarget;TargetScan;miRNATAP -0.1518300843814 2.67844057033477e-31 NA NA NA hsa-miR-200a-3p STX2 2.55218480823434 2.96135446816238e-51 -0.477957124111536 3.91337532111255e-12 MirTarget;miRNATAP -0.126548625374411 1.47734745929069e-22 NA NA NA hsa-miR-200a-5p STX2 2.58844508672328 1.79650654234569e-56 -0.477957124111536 3.91337532111255e-12 MirTarget -0.12410669000589 9.9752621827854e-21 NA NA NA hsa-miR-141-3p STX7 2.99777540204168 1.26370498493024e-78 -0.743223991128262 2.73753963588225e-35 TargetScan -0.126828124594219 4.50943871008587e-27 NA NA NA hsa-miR-429 STX7 2.84108892259147 3.88520896426515e-64 -0.743223991128262 2.73753963588225e-35 miRNATAP -0.110638806871916 9.82568356731731e-22 NA NA NA hsa-miR-141-3p STXBP1 2.99777540204168 1.26370498493024e-78 -1.33274174366283 2.07488419131401e-34 MirTarget;TargetScan;miRNATAP -0.248937943669874 1.26671983744587e-31 NA NA NA hsa-miR-200a-3p STXBP1 2.55218480823434 2.96135446816238e-51 -1.33274174366283 2.07488419131401e-34 MirTarget;miRNATAP -0.168343665572698 2.97110746534341e-15 NA NA NA hsa-miR-486-5p STXBP2 -3.87258704301474 1.22658629378451e-80 1.76291557476322 3.31620403093896e-64 miRanda -0.184735114496681 8.51324424425792e-29 NA NA NA hsa-miR-141-3p STXBP5 2.99777540204168 1.26370498493024e-78 -0.532336390386523 4.81218144261821e-08 TargetScan -0.110366755333999 5.74502684955627e-09 NA NA NA hsa-miR-21-5p STXBP5 2.32007501846389 3.08394781855554e-137 -0.532336390386523 4.81218144261821e-08 miRNAWalker2_validate -0.166193373708881 4.68683052604661e-08 NA NA NA hsa-miR-429 STXBP5 2.84108892259147 3.88520896426515e-64 -0.532336390386523 4.81218144261821e-08 miRanda -0.105504828372533 1.11994582548926e-08 NA NA NA hsa-miR-139-5p STXBP5L -3.25846663863766 2.62018989415003e-112 0.899525965907459 0.000425870656798328 miRanda;miRNATAP -0.283306449286081 6.36327454648724e-08 NA NA NA hsa-miR-145-5p STXBP5L -2.62703571936687 7.64402900188551e-88 0.899525965907459 0.000425870656798328 mirMAP -0.129274080853634 0.0299200533429409 NA NA NA hsa-miR-182-5p STXBP6 2.36408084103818 2.60011457600281e-72 -2.77290323792718 2.07722835803603e-35 mirMAP -0.612132040360229 3.83248322113182e-30 NA NA NA hsa-miR-200b-3p STXBP6 2.11744072703209 1.66710572104191e-43 -2.77290323792718 2.07722835803603e-35 TargetScan -0.481521083520953 1.64050653217567e-23 NA NA NA hsa-miR-429 SUCLA2 2.84108892259147 3.88520896426515e-64 -0.874849383134524 1.02013067046394e-39 miRanda -0.141019728439441 1.88616901173346e-28 NA NA NA hsa-miR-141-5p SUCNR1 2.38411349683216 4.56310582620282e-58 -1.6059959103694 1.5083053867126e-14 MirTarget -0.232446806427593 3.01713298059801e-07 NA NA NA hsa-miR-452-5p SULF1 -2.48486455572568 1.24430987974325e-33 1.4639961641687 4.60250282175774e-22 MirTarget -0.108461489183832 1.21638148843222e-05 NA NA NA hsa-miR-139-5p SULF2 -3.25846663863766 2.62018989415003e-112 0.870626617925511 4.85264275723055e-12 miRanda -0.139495679650338 9.2248388859226e-08 NA NA NA hsa-miR-452-5p SULF2 -2.48486455572568 1.24430987974325e-33 0.870626617925511 4.85264275723055e-12 mirMAP -0.101698984951153 5.41090333120449e-07 NA NA NA hsa-miR-139-5p SUMO3 -3.25846663863766 2.62018989415003e-112 0.391476532158168 4.7641137524592e-12 miRanda -0.10419848009012 1.58383657589852e-19 NA NA NA hsa-miR-10b-5p SURF6 -2.10996264627796 7.36811595736367e-72 0.430673706269963 2.38668215493021e-09 miRNAWalker2_validate -0.171538601679568 1.51403203123579e-19 NA NA NA hsa-miR-335-5p SUSD3 -2.61355235628987 2.6462884165886e-51 1.6591493875823 1.52993112632002e-10 miRNAWalker2_validate -0.106091446606184 0.0295117365161614 NA NA NA hsa-miR-429 SUSD5 2.84108892259147 3.88520896426515e-64 -0.30666217728129 0.0600042056037108 miRanda -0.186310431968161 1.17674366509268e-09 NA NA NA hsa-miR-141-3p SV2B 2.99777540204168 1.26370498493024e-78 -2.64738575414116 9.73898135717167e-43 MirTarget -0.49105538801218 1.48594053422606e-38 NA NA NA hsa-miR-182-5p SV2B 2.36408084103818 2.60011457600281e-72 -2.64738575414116 9.73898135717167e-43 mirMAP -0.493997204533828 1.09682534285038e-25 NA NA NA hsa-miR-200a-3p SV2B 2.55218480823434 2.96135446816238e-51 -2.64738575414116 9.73898135717167e-43 MirTarget -0.395015308653402 1.22114875893223e-25 NA NA NA hsa-miR-200b-3p SV2B 2.11744072703209 1.66710572104191e-43 -2.64738575414116 9.73898135717167e-43 mirMAP -0.402524915095762 1.4496305523351e-21 NA NA NA hsa-miR-200c-3p SV2B 2.07038651806183 6.84613386286599e-51 -2.64738575414116 9.73898135717167e-43 mirMAP -0.487872675991375 3.79946115212636e-26 NA NA NA hsa-miR-21-3p SV2B 2.17476065946878 5.15299442583591e-75 -2.64738575414116 9.73898135717167e-43 mirMAP -0.433297609415981 2.08763026041045e-16 NA NA NA hsa-miR-21-5p SV2B 2.32007501846389 3.08394781855554e-137 -2.64738575414116 9.73898135717167e-43 mirMAP -0.63070002075403 1.78985966619396e-24 NA NA NA hsa-miR-429 SV2B 2.84108892259147 3.88520896426515e-64 -2.64738575414116 9.73898135717167e-43 miRanda;mirMAP;miRNATAP -0.419390999357696 2.47424772374819e-29 NA NA NA hsa-miR-96-5p SV2B 3.24596558166606 1.92296159041707e-98 -2.64738575414116 9.73898135717167e-43 mirMAP -0.501346248395647 7.29077096427969e-39 NA NA NA hsa-miR-429 SVEP1 2.84108892259147 3.88520896426515e-64 -3.50443766246167 5.19163462333551e-73 miRanda -0.611225859237053 4.65352280676688e-60 NA NA NA hsa-miR-141-3p SVIL 2.99777540204168 1.26370498493024e-78 -1.02042711975721 4.10242843113864e-27 miRNATAP -0.187216915966905 4.02090130596551e-24 NA NA NA hsa-miR-200a-3p SVIL 2.55218480823434 2.96135446816238e-51 -1.02042711975721 4.10242843113864e-27 miRNATAP -0.150481698888998 2.11066073818249e-16 NA NA NA hsa-miR-375 SVIL 2.09893673049766 1.68351780396203e-16 -1.02042711975721 4.10242843113864e-27 miRNATAP -0.129173490849739 6.10930465127844e-25 NA NA NA hsa-miR-182-5p SWAP70 2.36408084103818 2.60011457600281e-72 -0.706858976777302 7.40269447194177e-24 MirTarget -0.122988393268622 4.11968050936252e-13 NA NA NA hsa-miR-200c-3p SWAP70 2.07038651806183 6.84613386286599e-51 -0.706858976777302 7.40269447194177e-24 MirTarget -0.109524232507323 4.73367128652567e-11 NA NA NA hsa-miR-429 SWAP70 2.84108892259147 3.88520896426515e-64 -0.706858976777302 7.40269447194177e-24 MirTarget;miRanda -0.107031577741251 1.66239349607725e-15 NA NA NA hsa-miR-145-5p SYAP1 -2.62703571936687 7.64402900188551e-88 0.828697534956492 3.30677430453784e-28 mirMAP -0.143769801168884 5.86228044774905e-16 NA NA NA hsa-miR-337-3p SYCP2 -2.14274617598363 2.70942896809734e-43 1.05161487459865 2.402892169769e-08 MirTarget -0.188656447932687 1.86328365047145e-06 NA NA NA hsa-miR-429 SYCP2L 2.84108892259147 3.88520896426515e-64 -0.898000038617994 0.000110342586515607 miRanda;miRNATAP -0.106126002719874 0.0163074397480424 NA NA NA hsa-miR-200b-3p SYDE1 2.11744072703209 1.66710572104191e-43 -0.59031661571319 1.56581328075237e-10 MirTarget;TargetScan -0.200677938410172 1.38895949195538e-25 NA NA NA hsa-miR-200c-3p SYDE1 2.07038651806183 6.84613386286599e-51 -0.59031661571319 1.56581328075237e-10 MirTarget;miRNATAP -0.260351825688736 7.16529254274237e-36 NA NA NA hsa-miR-429 SYDE1 2.84108892259147 3.88520896426515e-64 -0.59031661571319 1.56581328075237e-10 MirTarget;PITA;miRanda;miRNATAP -0.16766287949659 2.01275154469656e-22 NA NA NA hsa-miR-200c-3p SYNC 2.07038651806183 6.84613386286599e-51 -0.153981352248731 0.325479128978546 MirTarget -0.200356002288168 3.29332931696018e-08 NA NA NA hsa-miR-429 SYNE1 2.84108892259147 3.88520896426515e-64 -1.74324720013841 5.15222618343327e-53 miRanda -0.32331099804805 1.74250553803564e-50 NA NA NA hsa-miR-182-5p SYNE2 2.36408084103818 2.60011457600281e-72 -1.12890914158067 5.29295402528251e-34 miRNATAP -0.130089898104567 1.33783966183616e-08 NA NA NA hsa-miR-21-5p SYNE2 2.32007501846389 3.08394781855554e-137 -1.12890914158067 5.29295402528251e-34 miRNAWalker2_validate -0.314978762049673 4.46077566676347e-27 NA NA NA hsa-miR-429 SYNE2 2.84108892259147 3.88520896426515e-64 -1.12890914158067 5.29295402528251e-34 miRanda -0.111965568635118 7.20316334856976e-10 NA NA NA hsa-miR-96-5p SYNE2 3.24596558166606 1.92296159041707e-98 -1.12890914158067 5.29295402528251e-34 TargetScan;miRNATAP -0.152964465538199 4.25144445923095e-16 NA NA NA hsa-miR-335-5p SYNGR2 -2.61355235628987 2.6462884165886e-51 1.190743394294 4.95248235267062e-48 mirMAP -0.132417176575459 6.0294911287198e-17 NA NA NA hsa-miR-10b-5p SYNGR3 -2.10996264627796 7.36811595736367e-72 2.60416156250802 2.6068599752738e-42 mirMAP -0.487918316714139 1.41164281019307e-20 NA NA NA hsa-miR-335-5p SYNGR3 -2.61355235628987 2.6462884165886e-51 2.60416156250802 2.6068599752738e-42 miRNAWalker2_validate -0.293298750154205 1.64563247477269e-15 NA NA NA hsa-miR-429 SYNM 2.84108892259147 3.88520896426515e-64 -4.06797156584945 1.15604058141547e-76 MirTarget;miRanda -0.427877610486626 1.08961756323251e-21 NA NA NA hsa-miR-141-3p SYNPO2 2.99777540204168 1.26370498493024e-78 -2.92464505004565 6.88376936514486e-65 TargetScan;miRNATAP -0.527133057978033 1.82869178124705e-54 NA NA NA hsa-miR-200a-3p SYNPO2 2.55218480823434 2.96135446816238e-51 -2.92464505004565 6.88376936514486e-65 miRNATAP -0.445183095064665 2.64885409598501e-39 NA NA NA hsa-miR-200a-5p SYNPO2 2.58844508672328 1.79650654234569e-56 -2.92464505004565 6.88376936514486e-65 mirMAP -0.391428204516311 1.18096476383494e-28 NA NA NA hsa-miR-200b-3p SYNPO2 2.11744072703209 1.66710572104191e-43 -2.92464505004565 6.88376936514486e-65 mirMAP -0.468932116133846 4.68425320878927e-35 NA NA NA hsa-miR-21-5p SYNRG 2.32007501846389 3.08394781855554e-137 -0.319218610884267 1.14188296169254e-06 mirMAP -0.128433486101485 2.72109305887873e-10 NA NA NA hsa-miR-96-5p SYPL2 3.24596558166606 1.92296159041707e-98 -1.36373412197088 3.87503948814925e-27 miRNATAP -0.295004017762859 1.60024635469911e-32 NA NA NA hsa-miR-452-5p SYT1 -2.48486455572568 1.24430987974325e-33 0.523451617487376 0.0893148223385868 mirMAP;miRNATAP -0.418845673195687 4.16129562687673e-18 NA NA NA hsa-miR-200b-3p SYT11 2.11744072703209 1.66710572104191e-43 -0.486909650674836 1.01969242501068e-07 mirMAP -0.208477723087087 2.58516888064497e-28 NA NA NA hsa-miR-200c-3p SYT11 2.07038651806183 6.84613386286599e-51 -0.486909650674836 1.01969242501068e-07 mirMAP -0.244170422411085 3.31298673937728e-32 NA NA NA hsa-miR-429 SYT11 2.84108892259147 3.88520896426515e-64 -0.486909650674836 1.01969242501068e-07 mirMAP;miRNATAP -0.178339602148915 5.73254451858012e-26 NA NA NA hsa-miR-335-5p SYT12 -2.61355235628987 2.6462884165886e-51 0.517806379475144 0.0108597326312102 miRNAWalker2_validate -0.151637160017583 5.81422640906038e-05 NA NA NA hsa-miR-139-5p SYT13 -3.25846663863766 2.62018989415003e-112 2.91774638341289 1.4380254498439e-12 miRanda -0.570806452047958 1.99379034035948e-11 NA NA NA hsa-miR-21-5p SYT15 2.32007501846389 3.08394781855554e-137 -2.18139908762213 3.24969084514856e-44 MirTarget -0.475462414278198 3.39520711442358e-21 NA NA NA hsa-miR-375 SYT15 2.09893673049766 1.68351780396203e-16 -2.18139908762213 3.24969084514856e-44 miRNAWalker2_validate -0.158078795060436 1.99708304308751e-13 NA NA NA hsa-miR-141-3p SYT2 2.99777540204168 1.26370498493024e-78 -1.13874869529916 2.05373997501291e-19 mirMAP -0.197988556417279 1.1500448885582e-15 NA NA NA hsa-miR-182-5p SYT2 2.36408084103818 2.60011457600281e-72 -1.13874869529916 2.05373997501291e-19 mirMAP -0.21521586869179 1.51220048414849e-12 NA NA NA hsa-miR-200a-3p SYT2 2.55218480823434 2.96135446816238e-51 -1.13874869529916 2.05373997501291e-19 mirMAP -0.165133080686438 1.26263835227673e-11 NA NA NA hsa-miR-429 SYT2 2.84108892259147 3.88520896426515e-64 -1.13874869529916 2.05373997501291e-19 miRNATAP -0.140460403631012 7.50369950586682e-09 NA NA NA hsa-miR-96-5p SYT2 3.24596558166606 1.92296159041707e-98 -1.13874869529916 2.05373997501291e-19 mirMAP -0.190892846407414 3.51512470626769e-14 NA NA NA hsa-miR-335-5p SYT5 -2.61355235628987 2.6462884165886e-51 2.49606235343255 2.46726672276463e-16 miRNAWalker2_validate -0.337859297609328 3.50700480979251e-09 NA NA NA hsa-miR-141-3p SYT6 2.99777540204168 1.26370498493024e-78 -0.478835360484974 0.00434900423818834 MirTarget;TargetScan -0.102595700017579 0.00168883200818246 NA NA NA hsa-miR-429 SYT6 2.84108892259147 3.88520896426515e-64 -0.478835360484974 0.00434900423818834 miRNATAP -0.113484803065169 0.000360223938452081 NA NA NA hsa-miR-335-5p SYTL1 -2.61355235628987 2.6462884165886e-51 1.17475092026643 1.08163181277493e-15 miRNAWalker2_validate -0.137774909876992 5.83802391317227e-07 NA NA NA hsa-miR-144-5p SYTL5 -2.75914786146772 1.55794225315972e-50 0.431577313362793 0.208573060304143 mirMAP -0.118734860672777 0.0473012773649839 NA NA NA hsa-miR-141-3p TAC1 2.99777540204168 1.26370498493024e-78 -2.51990451890503 7.35598887494912e-17 MirTarget -0.510515327861923 3.50948483640586e-18 NA NA NA hsa-miR-200a-3p TAC1 2.55218480823434 2.96135446816238e-51 -2.51990451890503 7.35598887494912e-17 MirTarget -0.352757652820407 1.41720573149812e-09 NA NA NA hsa-miR-96-5p TAC1 3.24596558166606 1.92296159041707e-98 -2.51990451890503 7.35598887494912e-17 MirTarget;miRNATAP -0.50036880823693 6.07317834843784e-17 NA NA NA hsa-miR-141-5p TACC1 2.38411349683216 4.56310582620282e-58 -2.06208371139115 7.60562503452835e-59 MirTarget -0.375492952455609 7.69228466834534e-41 NA NA NA hsa-miR-182-5p TACC1 2.36408084103818 2.60011457600281e-72 -2.06208371139115 7.60562503452835e-59 MirTarget;miRNATAP -0.38520153963586 1.26529959956324e-34 NA NA NA hsa-miR-375 TACC1 2.09893673049766 1.68351780396203e-16 -2.06208371139115 7.60562503452835e-59 miRanda -0.137180959256047 1.47198134391006e-14 NA NA NA hsa-miR-429 TACC1 2.84108892259147 3.88520896426515e-64 -2.06208371139115 7.60562503452835e-59 miRanda;miRNATAP -0.369009390617666 1.13457465964035e-51 NA NA NA hsa-miR-96-5p TACC1 3.24596558166606 1.92296159041707e-98 -2.06208371139115 7.60562503452835e-59 MirTarget;TargetScan;miRNATAP -0.392143089149842 8.9723442864865e-54 NA NA NA hsa-miR-429 TACR1 2.84108892259147 3.88520896426515e-64 -3.80761123581243 8.98164119883573e-52 miRanda -0.516999251348983 1.17279302410745e-25 NA NA NA hsa-miR-335-5p TACSTD2 -2.61355235628987 2.6462884165886e-51 0.51453437422991 0.00271602577764519 miRNAWalker2_validate -0.103274228955513 0.00121304004564775 NA NA NA hsa-miR-21-5p TAF1 2.32007501846389 3.08394781855554e-137 -0.47789712927125 7.38157146680849e-11 miRNAWalker2_validate -0.198143508696272 2.11873995485272e-18 NA NA NA hsa-miR-139-5p TAF4 -3.25846663863766 2.62018989415003e-112 0.481700813822256 2.51287221593361e-14 miRanda -0.109600513035206 2.60789634005052e-17 NA NA NA hsa-miR-182-5p TAF4B 2.36408084103818 2.60011457600281e-72 -1.04392753121047 2.11654634898376e-13 MirTarget;miRNATAP -0.282478665902922 6.02453983158777e-17 NA NA NA hsa-miR-96-5p TAF4B 3.24596558166606 1.92296159041707e-98 -1.04392753121047 2.11654634898376e-13 TargetScan;miRNATAP -0.192134001626469 9.77528457450853e-12 NA NA NA hsa-miR-145-5p TAGLN2 -2.62703571936687 7.64402900188551e-88 0.920994827466144 3.75682216697375e-27 MirTarget;miRNATAP -0.144596671924885 8.47351125918979e-13 NA NA NA hsa-miR-141-5p TAL1 2.38411349683216 4.56310582620282e-58 -2.08023241347639 5.43559685808018e-64 MirTarget -0.395926607335071 1.20319219078832e-48 NA NA NA hsa-miR-429 TAL1 2.84108892259147 3.88520896426515e-64 -2.08023241347639 5.43559685808018e-64 miRanda -0.353740403493208 4.69993507297928e-50 NA NA NA hsa-miR-139-5p TANC2 -3.25846663863766 2.62018989415003e-112 0.645784897636979 5.11106873490809e-07 miRanda -0.111789666454162 2.57039221725262e-05 NA NA NA hsa-miR-182-5p TAOK1 2.36408084103818 2.60011457600281e-72 -1.02699433731773 5.06740042441332e-08 miRNATAP -0.115316228638248 0.0108914565818466 NA NA NA hsa-miR-200b-3p TAOK1 2.11744072703209 1.66710572104191e-43 -1.02699433731773 5.06740042441332e-08 MirTarget;TargetScan;mirMAP -0.220708220833645 3.52423430114308e-08 NA NA NA hsa-miR-200c-3p TAOK1 2.07038651806183 6.84613386286599e-51 -1.02699433731773 5.06740042441332e-08 MirTarget;mirMAP;miRNATAP -0.172415220398364 9.65606194605702e-05 NA NA NA hsa-miR-429 TAOK1 2.84108892259147 3.88520896426515e-64 -1.02699433731773 5.06740042441332e-08 MirTarget;mirMAP;miRNATAP -0.210385158373156 3.79964347855044e-09 NA NA NA hsa-miR-96-5p TAOK1 3.24596558166606 1.92296159041707e-98 -1.02699433731773 5.06740042441332e-08 miRNAWalker2_validate;TargetScan;miRNATAP -0.170489830318717 5.21335545807262e-06 NA NA NA hsa-miR-139-5p TAPBP -3.25846663863766 2.62018989415003e-112 0.939800770572923 5.15767613798376e-36 miRanda -0.154312174912311 9.23102506913239e-23 NA NA NA hsa-miR-452-5p TAPT1 -2.48486455572568 1.24430987974325e-33 -0.213679740968705 0.0107511697993454 MirTarget -0.140556201580506 2.19856978923992e-27 NA NA NA hsa-miR-145-5p TARS2 -2.62703571936687 7.64402900188551e-88 1.02415963397561 8.39575134988038e-47 MirTarget -0.216106062510888 4.29051016682803e-38 NA NA NA hsa-miR-429 TAT 2.84108892259147 3.88520896426515e-64 -4.1700211703831 1.44104525158907e-18 miRanda -0.311204622949121 0.000692270824935237 NA NA NA hsa-miR-21-3p TBC1D2B 2.17476065946878 5.15299442583591e-75 -0.710483100609729 1.38018429843516e-25 MirTarget -0.111121101693227 1.16865658016764e-09 NA NA NA hsa-miR-21-3p TBC1D4 2.17476065946878 5.15299442583591e-75 -1.3993249457625 1.48751427409567e-44 MirTarget -0.26065841716574 7.25295099689781e-22 NA NA NA hsa-miR-96-5p TBC1D4 3.24596558166606 1.92296159041707e-98 -1.3993249457625 1.48751427409567e-44 TargetScan -0.199633774486439 1.01089494199297e-22 NA NA NA hsa-miR-183-5p TBKBP1 2.95681814393872 1.09965777344285e-92 -0.482118461177772 5.12237283306555e-06 MirTarget -0.168092992611523 2.54330225033995e-14 NA NA NA hsa-miR-429 TBKBP1 2.84108892259147 3.88520896426515e-64 -0.482118461177772 5.12237283306555e-06 miRNATAP -0.103579506735717 2.264299157414e-07 NA NA NA hsa-miR-22-5p TBL1X 0.238328801322329 0.0377496760295305 0.0015032386389997 0.98628595429336 mirMAP -0.113674770615703 1.28737390658952e-05 NA NA NA hsa-miR-140-3p TBL1XR1 -1.25844395244141 5.29222651039892e-33 0.310361217922944 6.38304378176549e-06 PITA -0.222142997474086 4.16347181412021e-26 NA NA NA hsa-miR-542-3p TBL1XR1 0.568822103820889 8.5699075257651e-07 0.310361217922944 6.38304378176549e-06 MirTarget;PITA;miRanda -0.113018558915214 2.3915716506794e-08 NA NA NA hsa-miR-889-3p TBL1XR1 -0.377352927733213 0.00501260024755438 0.310361217922944 6.38304378176549e-06 MirTarget -0.136425907469045 3.79884694261387e-15 NA NA NA hsa-miR-96-5p TBX15 3.24596558166606 1.92296159041707e-98 -2.13092594868136 3.77907996713978e-53 MirTarget;TargetScan;miRNATAP -0.426112608325604 2.30334700479119e-54 NA NA NA hsa-miR-141-5p TBX18 2.38411349683216 4.56310582620282e-58 -1.63497901262982 4.33685552288116e-24 MirTarget;miRNATAP -0.351596963438141 4.39697970441048e-24 NA NA NA hsa-miR-200b-3p TBX18 2.11744072703209 1.66710572104191e-43 -1.63497901262982 4.33685552288116e-24 MirTarget -0.356983239935636 1.90998627232965e-25 NA NA NA hsa-miR-200c-3p TBX18 2.07038651806183 6.84613386286599e-51 -1.63497901262982 4.33685552288116e-24 MirTarget -0.455031771225271 2.22536796217204e-34 NA NA NA hsa-miR-429 TBX18 2.84108892259147 3.88520896426515e-64 -1.63497901262982 4.33685552288116e-24 MirTarget;PITA;miRanda -0.355247883712634 1.08417058442493e-31 NA NA NA hsa-miR-375 TBX19 2.09893673049766 1.68351780396203e-16 -0.383621002938068 0.00042122430408558 miRNAWalker2_validate -0.150005975753571 5.00204976701804e-27 NA NA NA hsa-miR-429 TBX2 2.84108892259147 3.88520896426515e-64 0.129922787207087 0.243301824733681 miRanda;miRNATAP -0.106112897598742 4.14813243204578e-07 NA NA NA hsa-miR-429 TBX4 2.84108892259147 3.88520896426515e-64 -1.38805371381094 6.12033897870948e-10 miRanda;miRNATAP -0.156581540036457 0.000260281035188404 NA NA NA hsa-miR-200b-3p TBX5 2.11744072703209 1.66710572104191e-43 -0.839510042139524 1.30543205804252e-07 TargetScan -0.315819038113751 1.72067633890594e-21 NA NA NA hsa-miR-429 TBX5 2.84108892259147 3.88520896426515e-64 -0.839510042139524 1.30543205804252e-07 PITA;miRanda;miRNATAP -0.279436733205694 4.14929690648315e-21 NA NA NA hsa-miR-96-5p TBX5 3.24596558166606 1.92296159041707e-98 -0.839510042139524 1.30543205804252e-07 MirTarget;TargetScan -0.262216651889181 3.38490995492502e-17 NA NA NA hsa-miR-182-5p TCEAL7 2.36408084103818 2.60011457600281e-72 -2.46928207205491 2.39891406469052e-61 MirTarget -0.425052678063089 2.3094919165496e-30 24021963 The purpose of this study was to examine the role of microRNA-182 and its target gene transcription elongation factor A-like 7 TCEAL7 in EC; The expression of miR-182 in human normal endometrial epithelial cells NEEC and in three human endometrial carcinoma cell lines HEC-1B RL95-2 and AN3CA was measured by qRT-PCR and the mRNA and protein expression of TCEAL7 were assessed in the same three endometrial carcinoma cell lines and NEEC by qRT-PCR and western blotting respectively; MiR-182 was significantly upregulated and TCEAL7 was downregulated in EC cell lines compared to NEEC endometrial cancer hsa-miR-429 TCEAL7 2.84108892259147 3.88520896426515e-64 -2.46928207205491 2.39891406469052e-61 miRanda -0.385638389275964 5.37628609930288e-40 NA NA NA hsa-miR-139-5p TCF19 -3.25846663863766 2.62018989415003e-112 1.00491571523943 2.08836698243406e-22 miRanda -0.233576816580608 1.68234863101844e-28 NA NA NA hsa-miR-139-5p TCF3 -3.25846663863766 2.62018989415003e-112 0.956078144144414 4.0063119417161e-35 PITA;miRanda -0.184610997268881 9.23397475608754e-31 NA NA NA hsa-miR-141-3p TCF4 2.99777540204168 1.26370498493024e-78 -1.10005019362634 5.35039549171217e-24 MirTarget;TargetScan;miRNATAP -0.337314487736614 5.38689179335519e-63 NA NA NA hsa-miR-183-5p TCF4 2.95681814393872 1.09965777344285e-92 -1.10005019362634 5.35039549171217e-24 miRNATAP -0.242631491471495 3.13638587631579e-26 NA NA NA hsa-miR-200a-3p TCF4 2.55218480823434 2.96135446816238e-51 -1.10005019362634 5.35039549171217e-24 MirTarget;miRNATAP -0.294925507037607 1.242682437187e-48 NA NA NA hsa-miR-200a-5p TCF4 2.58844508672328 1.79650654234569e-56 -1.10005019362634 5.35039549171217e-24 mirMAP;miRNATAP -0.228159452232684 5.19200125480376e-27 NA NA NA hsa-miR-200b-3p TCF4 2.11744072703209 1.66710572104191e-43 -1.10005019362634 5.35039549171217e-24 TargetScan;mirMAP -0.313264475548158 5.36537052084636e-44 NA NA NA hsa-miR-200c-3p TCF4 2.07038651806183 6.84613386286599e-51 -1.10005019362634 5.35039549171217e-24 mirMAP;miRNATAP -0.373371468855674 1.75142955154369e-52 NA NA NA hsa-miR-429 TCF4 2.84108892259147 3.88520896426515e-64 -1.10005019362634 5.35039549171217e-24 PITA;mirMAP;miRNATAP -0.283911519994361 1.97890475984256e-45 NA NA NA hsa-miR-96-5p TCF4 3.24596558166606 1.92296159041707e-98 -1.10005019362634 5.35039549171217e-24 TargetScan -0.27870591344585 8.05096829532336e-40 NA NA NA hsa-miR-107 TCF7 0.678998026350662 2.56224148930538e-16 -0.912929918624152 7.6350583246167e-11 miRanda -0.117353523993891 0.0433465482308839 NA NA NA hsa-miR-331-3p TCF7 0.74441480542886 1.17071235477799e-07 -0.912929918624152 7.6350583246167e-11 MirTarget;miRNATAP -0.153308578278305 7.71083941170175e-06 NA NA NA hsa-miR-141-3p TCF7L1 2.99777540204168 1.26370498493024e-78 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.199972471420516 6.28430074006789e-11 NA NA NA hsa-miR-200a-3p TCF7L1 2.55218480823434 2.96135446816238e-51 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.150558299078396 6.03400969336786e-07 NA NA NA hsa-miR-200b-3p TCF7L1 2.11744072703209 1.66710572104191e-43 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.168143697293025 5.41553060367198e-07 NA NA NA hsa-miR-200c-3p TCF7L1 2.07038651806183 6.84613386286599e-51 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.229533628135833 4.20710186780113e-10 NA NA NA hsa-miR-330-5p TCF7L1 0.626063225953928 3.42215028606779e-09 -1.43757533529955 1.98162937384072e-20 miRanda -0.102635088903389 0.0450445939950442 NA NA NA hsa-miR-429 TCF7L1 2.84108892259147 3.88520896426515e-64 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.134496234177534 7.39492362051745e-06 NA NA NA hsa-miR-107 TCF7L2 0.678998026350662 2.56224148930538e-16 -1.35100342592875 2.87469707303853e-37 miRanda -0.247661729975441 3.82905437520373e-08 NA NA NA hsa-miR-148b-3p TCF7L2 1.0552576751879 1.6679285705231e-29 -1.35100342592875 2.87469707303853e-37 miRNAWalker2_validate -0.36003166883339 8.1210275031183e-21 NA NA NA hsa-miR-15b-3p TCF7L2 1.12898579025388 1.18050912917317e-14 -1.35100342592875 2.87469707303853e-37 miRNATAP -0.105562680055541 3.49079711601082e-05 NA NA NA hsa-miR-182-5p TCF7L2 2.36408084103818 2.60011457600281e-72 -1.35100342592875 2.87469707303853e-37 miRNATAP -0.285458372953323 5.15013518210834e-29 NA NA NA hsa-miR-183-5p TCF7L2 2.95681814393872 1.09965777344285e-92 -1.35100342592875 2.87469707303853e-37 MirTarget;miRNATAP -0.256342247617245 6.25752369970953e-30 NA NA NA hsa-miR-193a-3p TCF7L2 0.310617999804917 0.00477640270974957 -1.35100342592875 2.87469707303853e-37 miRanda -0.13669345972878 7.45997149176231e-05 NA NA NA hsa-miR-338-3p TCF7L2 0.0799903526884966 0.575137668326679 -1.35100342592875 2.87469707303853e-37 miRanda -0.164700048645429 4.65832433017924e-10 NA NA NA hsa-miR-342-3p TCF7L2 1.21944481975657 6.81914373001202e-19 -1.35100342592875 2.87469707303853e-37 miRanda -0.233358442684096 1.49785192802606e-18 NA NA NA hsa-miR-429 TCF7L2 2.84108892259147 3.88520896426515e-64 -1.35100342592875 2.87469707303853e-37 miRNATAP -0.171121027184894 1.09303298527548e-16 NA NA NA hsa-miR-590-3p TCF7L2 1.27438512890514 1.03164723481469e-23 -1.35100342592875 2.87469707303853e-37 miRanda -0.121584977112315 6.35614091956812e-05 NA NA NA hsa-miR-625-5p TCF7L2 0.728939236913178 5.97591217674307e-08 -1.35100342592875 2.87469707303853e-37 MirTarget -0.196349842308205 7.37475139500119e-12 NA NA NA hsa-miR-96-5p TCF7L2 3.24596558166606 1.92296159041707e-98 -1.35100342592875 2.87469707303853e-37 MirTarget;TargetScan;miRNATAP -0.237827941772781 2.94405056699388e-29 NA NA NA hsa-miR-99b-3p TCF7L2 0.617175730947012 6.04327581183627e-09 -1.35100342592875 2.87469707303853e-37 MirTarget;miRNATAP -0.144432671942689 4.79981484254922e-05 NA NA NA hsa-miR-486-5p TCL6 -3.87258704301474 1.22658629378451e-80 1.21648657456971 1.74894940164056e-06 miRanda -0.104271918087871 0.00735803421527184 NA NA NA hsa-miR-429 TCP11L2 2.84108892259147 3.88520896426515e-64 -1.57929540668763 3.23397848777103e-36 miRanda -0.222238772804394 7.08888392478791e-20 NA NA NA hsa-miR-429 TCTEX1D1 2.84108892259147 3.88520896426515e-64 -0.671867265238395 3.63812704468826e-09 miRNATAP -0.148260778453754 5.50701796894445e-12 NA NA NA hsa-miR-429 TDRD10 2.84108892259147 3.88520896426515e-64 -2.55203366983314 5.16316335400428e-51 miRanda -0.373050556866392 2.18373228129544e-29 NA NA NA hsa-miR-141-3p TEAD1 2.99777540204168 1.26370498493024e-78 -1.39931853829988 3.11111186209198e-44 mirMAP -0.263313439559027 3.49779352863607e-41 NA NA NA hsa-miR-182-5p TEAD1 2.36408084103818 2.60011457600281e-72 -1.39931853829988 3.11111186209198e-44 mirMAP;miRNATAP -0.212255128480128 1.04317587028191e-17 NA NA NA hsa-miR-200a-3p TEAD1 2.55218480823434 2.96135446816238e-51 -1.39931853829988 3.11111186209198e-44 mirMAP -0.223034041783001 2.66140349888619e-30 NA NA NA hsa-miR-200a-5p TEAD1 2.58844508672328 1.79650654234569e-56 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.175995453381413 4.18244793430942e-18 NA NA NA hsa-miR-200b-3p TEAD1 2.11744072703209 1.66710572104191e-43 -1.39931853829988 3.11111186209198e-44 TargetScan -0.246914111025017 5.14311134476288e-30 NA NA NA hsa-miR-200c-3p TEAD1 2.07038651806183 6.84613386286599e-51 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.302039970867764 1.97528873326621e-37 NA NA NA hsa-miR-21-3p TEAD1 2.17476065946878 5.15299442583591e-75 -1.39931853829988 3.11111186209198e-44 mirMAP -0.203015123838267 1.60980082892842e-13 NA NA NA hsa-miR-429 TEAD1 2.84108892259147 3.88520896426515e-64 -1.39931853829988 3.11111186209198e-44 PITA;miRNATAP -0.223254951104642 8.62521560232663e-31 NA NA NA hsa-miR-96-5p TEAD1 3.24596558166606 1.92296159041707e-98 -1.39931853829988 3.11111186209198e-44 TargetScan;miRNATAP -0.228540035306696 1.37292843795799e-29 NA NA NA hsa-miR-21-3p TEF 2.17476065946878 5.15299442583591e-75 -1.42277931084315 1.72041150195617e-52 MirTarget -0.377598280489134 2.24982305514832e-53 NA NA NA hsa-miR-335-5p TERT -2.61355235628987 2.6462884165886e-51 2.18435908369283 1.94870803302696e-21 miRNAWalker2_validate -0.288284413581683 2.86646747178753e-11 NA NA NA hsa-miR-21-5p TET1 2.32007501846389 3.08394781855554e-137 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate -0.219366694016521 3.08336716646783e-09 NA NA NA hsa-miR-139-5p TET3 -3.25846663863766 2.62018989415003e-112 0.667896834715368 1.68552708580427e-14 miRanda -0.156108284825354 2.08942379158764e-18 NA NA NA hsa-miR-375 TF 2.09893673049766 1.68351780396203e-16 -4.45842792468487 7.01043250085875e-45 miRanda -0.446184309819529 3.13958326432815e-25 NA NA NA hsa-miR-139-3p TFAP2A -3.44089023199323 1.67292890850702e-91 1.56008287592438 1.43068387139102e-26 miRNATAP -0.265937441036601 1.15526550626606e-23 NA NA NA hsa-miR-486-5p TFAP2A -3.87258704301474 1.22658629378451e-80 1.56008287592438 1.43068387139102e-26 miRanda -0.234580020039319 5.85971037873064e-26 NA NA NA hsa-miR-144-5p TFAP2B -2.75914786146772 1.55794225315972e-50 -0.997243233314241 0.0332611844367993 miRNATAP -0.169108498728028 0.0386196203732917 NA NA NA hsa-miR-96-5p TFAP2B 3.24596558166606 1.92296159041707e-98 -0.997243233314241 0.0332611844367993 TargetScan -0.200126645620072 0.0310060298224952 NA NA NA hsa-miR-486-5p TFAP2C -3.87258704301474 1.22658629378451e-80 -0.119702802451508 0.438475124818021 miRanda -0.125813832536471 6.74762672229992e-08 NA NA NA hsa-miR-139-5p TFB2M -3.25846663863766 2.62018989415003e-112 0.779568357318669 3.52175999295873e-31 miRanda -0.166289996731883 1.4042235534992e-33 NA NA NA hsa-miR-21-3p TFCP2L1 2.17476065946878 5.15299442583591e-75 -1.04857248296961 7.45112968563675e-06 mirMAP -0.179811428577046 0.00368788072139506 NA NA NA hsa-miR-21-5p TFCP2L1 2.32007501846389 3.08394781855554e-137 -1.04857248296961 7.45112968563675e-06 mirMAP -0.240788917483754 0.00101509498232268 NA NA NA hsa-miR-200b-3p TFE3 2.11744072703209 1.66710572104191e-43 -0.446367250657458 1.19299069465675e-20 MirTarget -0.111070475427735 1.7031702324767e-28 NA NA NA hsa-miR-200b-3p TFPI 2.11744072703209 1.66710572104191e-43 -2.24834899858951 2.16889870319697e-54 MirTarget -0.448339699307029 2.56263287697859e-47 NA NA NA hsa-miR-200c-3p TFPI 2.07038651806183 6.84613386286599e-51 -2.24834899858951 2.16889870319697e-54 MirTarget -0.505609612406096 5.19553073856163e-50 NA NA NA hsa-miR-429 TFPI 2.84108892259147 3.88520896426515e-64 -2.24834899858951 2.16889870319697e-54 MirTarget;miRanda -0.39870208866977 6.82178608380597e-47 NA NA NA hsa-miR-141-3p TGFB2 2.99777540204168 1.26370498493024e-78 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 NA NA NA hsa-miR-200a-3p TGFB2 2.55218480823434 2.96135446816238e-51 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-375 TGFB2 2.09893673049766 1.68351780396203e-16 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate -0.118032596246175 1.14664596099986e-06 NA NA NA hsa-miR-429 TGFB2 2.84108892259147 3.88520896426515e-64 -0.568239705690126 0.00206510120463672 miRNATAP -0.113931562701627 0.00112595441618086 NA NA NA hsa-miR-511-5p TGFB3 -2.27545475897362 3.84085514050558e-36 0.82398957056453 1.83180841509129e-11 MirTarget -0.161630488068991 4.28099557548626e-13 NA NA NA hsa-miR-200b-3p TGFBR1 2.11744072703209 1.66710572104191e-43 -0.276773756857041 0.00374479166499862 mirMAP -0.133382190063293 2.90573705377005e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-429 TGFBR1 2.84108892259147 3.88520896426515e-64 -0.276773756857041 0.00374479166499862 miRanda;miRNATAP -0.101210444459427 1.79034747294782e-08 NA NA NA hsa-miR-21-5p TGFBR2 2.32007501846389 3.08394781855554e-137 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.537594809270263 3.47307989185754e-40 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-429 TGFBR2 2.84108892259147 3.88520896426515e-64 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.404995702801572 1.14853648012577e-64 NA NA NA hsa-miR-182-5p TGFBR3 2.36408084103818 2.60011457600281e-72 -3.32389218515653 1.82193869897655e-62 miRNATAP -0.483801057258478 4.85727221592697e-22 NA NA NA hsa-miR-21-5p TGFBR3 2.32007501846389 3.08394781855554e-137 -3.32389218515653 1.82193869897655e-62 miRNAWalker2_validate -0.991051228961082 2.79000222280721e-56 NA NA NA hsa-miR-429 TGFBR3 2.84108892259147 3.88520896426515e-64 -3.32389218515653 1.82193869897655e-62 miRanda -0.442656446217992 3.4698799235337e-29 NA NA NA hsa-miR-139-5p TGIF2 -3.25846663863766 2.62018989415003e-112 0.381752628831196 2.37116884002192e-05 miRanda -0.119636486727811 9.39109121090686e-11 NA NA NA hsa-miR-429 TGM5 2.84108892259147 3.88520896426515e-64 -1.98128363960087 4.43400613151183e-12 miRNATAP -0.161062952828944 0.00336983949122139 NA NA NA hsa-miR-139-5p THBS2 -3.25846663863766 2.62018989415003e-112 0.769808163205687 9.78636441866493e-07 miRanda -0.18351393710485 1.38608699702018e-08 NA NA NA hsa-miR-200b-3p THEMIS 2.11744072703209 1.66710572104191e-43 -0.694831838764676 0.000974328878154886 mirMAP -0.134705394978116 0.00263329809583339 NA NA NA hsa-miR-200c-3p THEMIS 2.07038651806183 6.84613386286599e-51 -0.694831838764676 0.000974328878154886 mirMAP -0.106515438271245 0.0307814013429153 NA NA NA hsa-miR-375 THEMIS 2.09893673049766 1.68351780396203e-16 -0.694831838764676 0.000974328878154886 miRanda -0.10340398887163 0.000200544360169319 NA NA NA hsa-miR-429 THEMIS 2.84108892259147 3.88520896426515e-64 -0.694831838764676 0.000974328878154886 mirMAP -0.172469190781125 1.52812682256405e-05 NA NA NA hsa-miR-139-5p THOC3 -3.25846663863766 2.62018989415003e-112 0.913981446303981 1.50329044322309e-34 miRanda -0.207083194419027 2.65621854962966e-42 NA NA NA hsa-miR-141-5p THRA 2.38411349683216 4.56310582620282e-58 -1.02955320595519 1.31044247003034e-25 mirMAP -0.151604501001454 1.8850439035373e-12 NA NA NA hsa-miR-183-5p THRA 2.95681814393872 1.09965777344285e-92 -1.02955320595519 1.31044247003034e-25 mirMAP -0.18085610364795 6.43545001960361e-18 NA NA NA hsa-miR-200b-3p THRA 2.11744072703209 1.66710572104191e-43 -1.02955320595519 1.31044247003034e-25 TargetScan;mirMAP -0.111191523388094 2.04291348368424e-07 NA NA NA hsa-miR-200c-3p THRA 2.07038651806183 6.84613386286599e-51 -1.02955320595519 1.31044247003034e-25 mirMAP -0.164553566630917 1.94353061935044e-12 NA NA NA hsa-miR-429 THRA 2.84108892259147 3.88520896426515e-64 -1.02955320595519 1.31044247003034e-25 mirMAP -0.131033993613158 5.27548858296852e-12 NA NA NA hsa-miR-141-3p THRB 2.99777540204168 1.26370498493024e-78 -1.90956725674414 3.33207199356048e-40 MirTarget;TargetScan;miRNATAP -0.281746020368853 8.05412831431655e-23 NA NA NA hsa-miR-141-5p THRB 2.38411349683216 4.56310582620282e-58 -1.90956725674414 3.33207199356048e-40 MirTarget -0.214304593668378 2.60184957749581e-11 NA NA NA hsa-miR-200a-3p THRB 2.55218480823434 2.96135446816238e-51 -1.90956725674414 3.33207199356048e-40 MirTarget;miRNATAP -0.216248963256199 2.81569538365581e-14 NA NA NA hsa-miR-200b-3p THRB 2.11744072703209 1.66710572104191e-43 -1.90956725674414 3.33207199356048e-40 TargetScan;mirMAP -0.197678692990186 5.08028621353357e-10 NA NA NA hsa-miR-21-5p THRB 2.32007501846389 3.08394781855554e-137 -1.90956725674414 3.33207199356048e-40 MirTarget;miRNATAP -0.535675702705463 3.68641251340418e-32 21159845 Direct interaction with THRB was shown for miR-21 and miR-146a; We observed lower levels of THRB transcripts in cell lines transfected with miR-21 -146a and -221 down-regulation of 37-48%; P < 0.0001 but not with miR-181a; The analysis of tumor/normal tissue pairs revealed down-regulation of THRB in 11 of 13 pairs 1.3- to 9.1-fold and up-regulation of miR-21 -146a -181a and -221 in almost all pairs thyroid cancer hsa-miR-429 THRB 2.84108892259147 3.88520896426515e-64 -1.90956725674414 3.33207199356048e-40 miRNATAP -0.265570428969653 2.21232587015552e-21 NA NA NA hsa-miR-141-5p THRSP 2.38411349683216 4.56310582620282e-58 -4.09570284668685 1.28939309794088e-35 MirTarget -0.515569351910813 1.55133212814538e-12 NA NA NA hsa-miR-141-3p THSD7A 2.99777540204168 1.26370498493024e-78 -1.80803008417679 7.98411384414828e-26 TargetScan -0.470041136915774 3.27174264298659e-47 NA NA NA hsa-miR-200b-3p THSD7A 2.11744072703209 1.66710572104191e-43 -1.80803008417679 7.98411384414828e-26 TargetScan -0.401053024783458 3.56656415289921e-28 NA NA NA hsa-miR-429 THSD7A 2.84108892259147 3.88520896426515e-64 -1.80803008417679 7.98411384414828e-26 PITA;miRanda;miRNATAP -0.382735008388651 2.86102521071726e-32 NA NA NA hsa-miR-183-5p THSD7B 2.95681814393872 1.09965777344285e-92 -2.91449392763338 9.78052029338045e-37 miRNATAP -0.502552741349505 2.56325843710533e-24 NA NA NA hsa-miR-375 TIFAB 2.09893673049766 1.68351780396203e-16 1.31202661231825 2.66225584391736e-08 miRanda -0.160880984653909 2.52018252269725e-07 NA NA NA hsa-miR-335-5p TIGD3 -2.61355235628987 2.6462884165886e-51 2.00286206658955 2.56094222448724e-47 miRNAWalker2_validate -0.239057315903112 4.10427466134726e-19 NA NA NA hsa-miR-139-5p TIMM8A -3.25846663863766 2.62018989415003e-112 0.397797820142315 1.15183748762533e-08 miRanda -0.128606908470079 9.25387595209036e-20 NA NA NA hsa-miR-182-5p TIMP2 2.36408084103818 2.60011457600281e-72 -0.790977606892998 7.91966411856086e-15 mirMAP -0.272077122513136 2.73429352076683e-30 NA NA NA hsa-miR-200b-3p TIMP2 2.11744072703209 1.66710572104191e-43 -0.790977606892998 7.91966411856086e-15 TargetScan -0.281885890717356 1.36324026240457e-41 23205572 A novel target of miR-200b tissue inhibitor of metalloproteinase 2 TIMP2 was predicted using a bioinformatics approach and was confirmed in human endometrial cancer cell line HEC-1A cells by luciferase assay quantitative real-time polymerase chain reaction western blotting and enzyme-linked immunosorbent assay; We found that miR-200b repressed TIMP2 expression at both the messenger RNA and protein levels although a family member miR-200a had no such effect; Using reverse gelatin zymography we showed that miR-200b enhances matrix metallopeptidase 2 MMP2 activity by downregulating TIMP2 expression in HEC-1A cells endometrial cancer hsa-miR-200c-3p TIMP2 2.07038651806183 6.84613386286599e-51 -0.790977606892998 7.91966411856086e-15 miRTarBase -0.348884866594025 7.49589633579639e-54 NA NA NA hsa-miR-429 TIMP2 2.84108892259147 3.88520896426515e-64 -0.790977606892998 7.91966411856086e-15 PITA;miRanda;miRNATAP -0.230776213209111 1.25436986384176e-34 NA NA NA hsa-miR-96-5p TIMP2 3.24596558166606 1.92296159041707e-98 -0.790977606892998 7.91966411856086e-15 mirMAP -0.261149502830599 4.70871667687375e-41 NA NA NA hsa-miR-21-5p TIMP3 2.32007501846389 3.08394781855554e-137 -1.20767978742507 3.47571209381163e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.194696613681374 9.95965481820086e-06 23936642;20346171;21820586;25720799;25587717 Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;tumorigenesis;tumorigenesis;poor survival;metastasis;progression; breast cancer;breast cancer;kidney renal cell cancer;liver cancer;melanoma hsa-miR-429 TINAGL1 2.84108892259147 3.88520896426515e-64 -2.01320915178555 3.53973880914159e-39 miRanda -0.180605781674723 2.61601946859852e-09 NA NA NA hsa-miR-200b-3p TJP1 2.11744072703209 1.66710572104191e-43 -0.765496503458334 3.43269584339806e-25 TargetScan -0.129222453934998 3.51217254190336e-16 NA NA NA hsa-miR-429 TJP1 2.84108892259147 3.88520896426515e-64 -0.765496503458334 3.43269584339806e-25 miRNATAP -0.120144248580405 1.82223795569378e-17 NA NA NA hsa-miR-335-5p TJP3 -2.61355235628987 2.6462884165886e-51 2.61452451346623 2.74998802724398e-39 miRNAWalker2_validate -0.327181536896693 1.00873700675959e-17 NA NA NA hsa-miR-182-5p TK2 2.36408084103818 2.60011457600281e-72 -0.945845591912347 8.82078867072266e-48 mirMAP -0.144237178967195 3.39111507379188e-19 NA NA NA hsa-miR-429 TK2 2.84108892259147 3.88520896426515e-64 -0.945845591912347 8.82078867072266e-48 miRNATAP -0.170634557630332 4.90947347000328e-43 NA NA NA hsa-miR-96-5p TK2 3.24596558166606 1.92296159041707e-98 -0.945845591912347 8.82078867072266e-48 mirMAP -0.148898148054883 1.37621853226626e-29 NA NA NA hsa-miR-375 TLE4 2.09893673049766 1.68351780396203e-16 -1.51465899922261 3.23215726524777e-37 miRanda -0.18727485562099 1.84260587974749e-32 NA NA NA hsa-miR-429 TLE4 2.84108892259147 3.88520896426515e-64 -1.51465899922261 3.23215726524777e-37 miRNATAP -0.201677034583471 2.52903543486439e-18 NA NA NA hsa-miR-429 TLL1 2.84108892259147 3.88520896426515e-64 -2.00025079989534 1.66738573445116e-27 miRanda -0.442575961323838 8.94408385384592e-38 NA NA NA hsa-miR-96-5p TLL1 3.24596558166606 1.92296159041707e-98 -2.00025079989534 1.66738573445116e-27 TargetScan;miRNATAP -0.476566589683275 2.38879954738524e-40 NA NA NA hsa-miR-182-5p TLN1 2.36408084103818 2.60011457600281e-72 -0.806997562437992 3.90911750864684e-41 miRNATAP -0.191975318864003 4.55718943867516e-41 NA NA NA hsa-miR-200b-3p TLN1 2.11744072703209 1.66710572104191e-43 -0.806997562437992 3.90911750864684e-41 TargetScan -0.16307330532858 3.45299485359747e-37 NA NA NA hsa-miR-200c-3p TLN1 2.07038651806183 6.84613386286599e-51 -0.806997562437992 3.90911750864684e-41 miRNATAP -0.211158596185854 6.01914896728009e-53 NA NA NA hsa-miR-429 TLN1 2.84108892259147 3.88520896426515e-64 -0.806997562437992 3.90911750864684e-41 miRanda;miRNATAP -0.143999025204889 2.52358242915518e-36 NA NA NA hsa-miR-96-5p TLN1 3.24596558166606 1.92296159041707e-98 -0.806997562437992 3.90911750864684e-41 TargetScan;miRNATAP -0.162553094647716 6.83509476584792e-43 NA NA NA hsa-miR-141-3p TLN2 2.99777540204168 1.26370498493024e-78 -1.83784711672792 1.84067578710874e-73 TargetScan -0.364377427050569 7.04292918886026e-77 NA NA NA hsa-miR-182-5p TLN2 2.36408084103818 2.60011457600281e-72 -1.83784711672792 1.84067578710874e-73 mirMAP -0.316075142425221 1.38926726226767e-35 NA NA NA hsa-miR-200a-3p TLN2 2.55218480823434 2.96135446816238e-51 -1.83784711672792 1.84067578710874e-73 mirMAP -0.279655297923562 5.01589411621067e-44 NA NA NA hsa-miR-200b-3p TLN2 2.11744072703209 1.66710572104191e-43 -1.83784711672792 1.84067578710874e-73 TargetScan -0.290211927011083 5.65007406224696e-38 NA NA NA hsa-miR-200c-3p TLN2 2.07038651806183 6.84613386286599e-51 -1.83784711672792 1.84067578710874e-73 miRNATAP -0.398854834101476 5.91754554874285e-62 NA NA NA hsa-miR-429 TLN2 2.84108892259147 3.88520896426515e-64 -1.83784711672792 1.84067578710874e-73 PITA;miRanda;miRNATAP -0.284371176306131 2.4760281521471e-46 NA NA NA hsa-miR-96-5p TLN2 3.24596558166606 1.92296159041707e-98 -1.83784711672792 1.84067578710874e-73 mirMAP -0.329613138870725 1.81292796737155e-58 NA NA NA hsa-miR-21-5p TLR4 2.32007501846389 3.08394781855554e-137 -1.6490372510276 1.59824287329687e-47 miRNAWalker2_validate -0.359793062620959 1.10927793812338e-22 27286259 For in vivo relevance expression of TLR4 was correlated with miR-21 expression and ROS production in freshly isolated untreated primary human lung cancer cells lung cancer hsa-miR-335-5p TLX3 -2.61355235628987 2.6462884165886e-51 0.974256918949946 0.000132329813217466 miRNAWalker2_validate -0.255882244253728 6.03144851584016e-08 NA NA NA hsa-miR-96-5p TM4SF18 3.24596558166606 1.92296159041707e-98 -2.07946485024883 6.63312918032408e-50 TargetScan -0.286718258632666 1.62564933996955e-23 NA NA NA hsa-miR-10b-5p TMC6 -2.10996264627796 7.36811595736367e-72 1.07676628738519 2.99716490986362e-26 mirMAP -0.27028629314411 2.89911488112406e-23 NA NA NA hsa-miR-335-5p TMC6 -2.61355235628987 2.6462884165886e-51 1.07676628738519 2.99716490986362e-26 miRNAWalker2_validate -0.145335605733959 3.66321363504099e-14 NA NA NA hsa-miR-182-5p TMCC3 2.36408084103818 2.60011457600281e-72 -1.30038155800341 9.80183512573792e-29 mirMAP -0.216893713595577 2.34361814593819e-14 NA NA NA hsa-miR-183-5p TMCC3 2.95681814393872 1.09965777344285e-92 -1.30038155800341 9.80183512573792e-29 MirTarget;miRNATAP -0.195634460136581 6.84198742855074e-15 NA NA NA hsa-miR-21-3p TMCC3 2.17476065946878 5.15299442583591e-75 -1.30038155800341 9.80183512573792e-29 MirTarget -0.203409248825222 1.15072275680907e-10 NA NA NA hsa-miR-139-5p TMED2 -3.25846663863766 2.62018989415003e-112 0.493660982843192 4.00513738552719e-15 miRanda -0.125852065630555 7.99996658381305e-23 NA NA NA hsa-miR-378a-5p TMED7 -2.43173551693523 1.44932837789175e-68 0.0657478087693226 0.376561952531058 MirTarget -0.117114463344123 1.6856191291136e-12 NA NA NA hsa-miR-452-5p TMED7 -2.48486455572568 1.24430987974325e-33 0.0657478087693226 0.376561952531058 MirTarget -0.113049523988338 1.3370815950115e-22 NA NA NA hsa-miR-139-5p TMEFF1 -3.25846663863766 2.62018989415003e-112 0.19005141193122 0.108846594958955 miRanda -0.117782982755988 1.22509712404197e-06 NA NA NA hsa-miR-375 TMEFF1 2.09893673049766 1.68351780396203e-16 0.19005141193122 0.108846594958955 miRanda -0.109044320303904 1.6023341187386e-12 NA NA NA hsa-miR-429 TMEM100 2.84108892259147 3.88520896426515e-64 -4.08470298388118 3.41393720549828e-65 miRanda -0.616470398320346 2.56759872985856e-39 NA NA NA hsa-miR-335-5p TMEM105 -2.61355235628987 2.6462884165886e-51 0.602518116533227 0.0158578087438439 mirMAP -0.202096422679671 1.27217175406662e-05 NA NA NA hsa-miR-141-3p TMEM108 2.99777540204168 1.26370498493024e-78 -0.580310191018694 0.00285718388503917 mirMAP -0.132320945372234 0.000471240582415183 NA NA NA hsa-miR-182-5p TMEM108 2.36408084103818 2.60011457600281e-72 -0.580310191018694 0.00285718388503917 mirMAP -0.235353451741092 3.50413685782967e-07 NA NA NA hsa-miR-183-5p TMEM108 2.95681814393872 1.09965777344285e-92 -0.580310191018694 0.00285718388503917 miRNAWalker2_validate -0.188350712075831 4.16217205303975e-06 NA NA NA hsa-miR-200a-3p TMEM108 2.55218480823434 2.96135446816238e-51 -0.580310191018694 0.00285718388503917 mirMAP -0.130766547323886 0.000427848538666159 NA NA NA hsa-miR-96-5p TMEM108 3.24596558166606 1.92296159041707e-98 -0.580310191018694 0.00285718388503917 mirMAP -0.168947895942167 1.08951212385525e-05 NA NA NA hsa-miR-429 TMEM119 2.84108892259147 3.88520896426515e-64 0.292554170269455 0.0310768761172361 miRanda -0.145160844289454 1.29308173195369e-08 NA NA NA hsa-miR-96-5p TMEM119 3.24596558166606 1.92296159041707e-98 0.292554170269455 0.0310768761172361 MirTarget -0.138281590479185 2.19926387389126e-07 NA NA NA hsa-miR-511-5p TMEM129 -2.27545475897362 3.84085514050558e-36 0.198161912017476 0.0206806922600351 MirTarget -0.117519824088176 1.9703321064154e-14 NA NA NA hsa-miR-141-3p TMEM130 2.99777540204168 1.26370498493024e-78 -0.151401709333805 0.433770192378502 MirTarget;TargetScan -0.15529610707997 3.41284676746256e-05 NA NA NA hsa-miR-200a-3p TMEM130 2.55218480823434 2.96135446816238e-51 -0.151401709333805 0.433770192378502 MirTarget -0.141026223203448 0.00012663030238112 NA NA NA hsa-miR-10b-5p TMEM132A -2.10996264627796 7.36811595736367e-72 2.46030796137933 4.01508767373556e-61 mirMAP -0.574851392865519 1.76946476517617e-45 NA NA NA hsa-miR-141-5p TMEM132B 2.38411349683216 4.56310582620282e-58 -1.14588577432282 2.75849828413831e-12 MirTarget;mirMAP -0.249671461357603 1.40757569789863e-12 NA NA NA hsa-miR-429 TMEM132B 2.84108892259147 3.88520896426515e-64 -1.14588577432282 2.75849828413831e-12 miRNATAP -0.233812093436884 4.84639935627513e-14 NA NA NA hsa-miR-141-3p TMEM135 2.99777540204168 1.26370498493024e-78 -0.662276560426261 1.65116614173733e-11 MirTarget;TargetScan -0.121638969831776 2.1777902714527e-10 NA NA NA hsa-miR-200a-3p TMEM135 2.55218480823434 2.96135446816238e-51 -0.662276560426261 1.65116614173733e-11 MirTarget -0.132409119844956 1.62565609138772e-12 NA NA NA hsa-miR-429 TMEM135 2.84108892259147 3.88520896426515e-64 -0.662276560426261 1.65116614173733e-11 miRanda -0.134846459214364 4.21929764744396e-13 NA NA NA hsa-miR-96-5p TMEM163 3.24596558166606 1.92296159041707e-98 -0.786403004382042 2.6866412688771e-07 MirTarget;TargetScan;miRNATAP -0.119361172582251 8.46760734568592e-05 NA NA NA hsa-miR-182-5p TMEM169 2.36408084103818 2.60011457600281e-72 -0.531107010831258 1.82080982256731e-06 miRNATAP -0.190425511547741 4.61250115152559e-13 NA NA NA hsa-miR-429 TMEM169 2.84108892259147 3.88520896426515e-64 -0.531107010831258 1.82080982256731e-06 miRNATAP -0.135929088366455 9.27416390202286e-11 NA NA NA hsa-miR-96-5p TMEM169 3.24596558166606 1.92296159041707e-98 -0.531107010831258 1.82080982256731e-06 MirTarget;TargetScan;miRNATAP -0.144978208563358 3.51436017590936e-11 NA NA NA hsa-miR-141-3p TMEM170B 2.99777540204168 1.26370498493024e-78 -1.50335449366583 7.54725989395169e-43 MirTarget;TargetScan;miRNATAP -0.262820919850681 3.52801180749301e-34 NA NA NA hsa-miR-182-5p TMEM170B 2.36408084103818 2.60011457600281e-72 -1.50335449366583 7.54725989395169e-43 miRNATAP -0.222600587369143 1.91688092032391e-16 NA NA NA hsa-miR-200a-3p TMEM170B 2.55218480823434 2.96135446816238e-51 -1.50335449366583 7.54725989395169e-43 MirTarget;miRNATAP -0.240821801746225 1.07445943843933e-29 NA NA NA hsa-miR-200b-3p TMEM170B 2.11744072703209 1.66710572104191e-43 -1.50335449366583 7.54725989395169e-43 TargetScan -0.266180835867404 2.54867491574085e-29 NA NA NA hsa-miR-200c-3p TMEM170B 2.07038651806183 6.84613386286599e-51 -1.50335449366583 7.54725989395169e-43 miRNATAP -0.290974485300329 5.72219152421604e-29 NA NA NA hsa-miR-21-5p TMEM170B 2.32007501846389 3.08394781855554e-137 -1.50335449366583 7.54725989395169e-43 mirMAP -0.509535208739174 2.47092730947633e-51 NA NA NA hsa-miR-429 TMEM170B 2.84108892259147 3.88520896426515e-64 -1.50335449366583 7.54725989395169e-43 miRanda;miRNATAP -0.23930748683927 9.97685643979475e-30 NA NA NA hsa-miR-96-5p TMEM170B 3.24596558166606 1.92296159041707e-98 -1.50335449366583 7.54725989395169e-43 MirTarget;TargetScan;miRNATAP -0.23416335789899 4.35023744229459e-26 NA NA NA hsa-miR-10b-5p TMEM183A -2.10996264627796 7.36811595736367e-72 0.810543764087037 1.49789304918469e-41 MirTarget -0.200709800065263 1.21301012539894e-35 NA NA NA hsa-miR-139-5p TMEM183A -3.25846663863766 2.62018989415003e-112 0.810543764087037 1.49789304918469e-41 miRanda -0.177151756388586 2.20998502114522e-47 NA NA NA hsa-miR-139-5p TMEM184A -3.25846663863766 2.62018989415003e-112 1.87482694800895 3.09472109959825e-30 miRNATAP -0.242904354063827 2.33009088207347e-12 NA NA NA hsa-miR-139-5p TMEM198 -3.25846663863766 2.62018989415003e-112 0.850862446059524 9.77984265384163e-11 miRanda -0.120757200035383 9.59709859724438e-06 NA NA NA hsa-miR-335-5p TMEM198 -2.61355235628987 2.6462884165886e-51 0.850862446059524 9.77984265384163e-11 miRNAWalker2_validate -0.101489490656983 3.80758426576173e-05 NA NA NA hsa-miR-429 TMEM2 2.84108892259147 3.88520896426515e-64 -0.227178670395279 0.0272816341402515 miRanda -0.126053606068046 6.43682915472702e-11 NA NA NA hsa-miR-139-5p TMEM215 -3.25846663863766 2.62018989415003e-112 2.65768345418265 2.3521799065528e-20 miRanda -0.244197056545286 5.41912246512995e-05 NA NA NA hsa-miR-452-5p TMEM229B -2.48486455572568 1.24430987974325e-33 0.727265089473085 3.07635214377309e-08 MirTarget -0.215291353803972 1.02842361156985e-25 NA NA NA hsa-miR-429 TMEM232 2.84108892259147 3.88520896426515e-64 -1.06305508246841 6.67585286009058e-07 miRanda -0.14230803924357 0.000475297951501844 NA NA NA hsa-miR-452-5p TMEM232 -2.48486455572568 1.24430987974325e-33 -1.06305508246841 6.67585286009058e-07 MirTarget -0.221650669813412 7.60839038461403e-11 NA NA NA hsa-miR-200b-3p TMEM43 2.11744072703209 1.66710572104191e-43 -0.763185893816313 4.24636950864574e-43 MirTarget -0.130572977271474 1.24927813264347e-27 NA NA NA hsa-miR-200c-3p TMEM43 2.07038651806183 6.84613386286599e-51 -0.763185893816313 4.24636950864574e-43 MirTarget -0.155461686323236 1.7017036656773e-32 NA NA NA hsa-miR-429 TMEM43 2.84108892259147 3.88520896426515e-64 -0.763185893816313 4.24636950864574e-43 MirTarget;miRanda -0.115285102347455 5.25107940533284e-27 NA NA NA hsa-miR-335-5p TMEM45B -2.61355235628987 2.6462884165886e-51 0.690717944732139 0.0138422868082045 miRNAWalker2_validate -0.124213641227868 0.0173980782663154 NA NA NA hsa-miR-182-5p TMEM47 2.36408084103818 2.60011457600281e-72 -2.06485952706021 1.44087411554797e-48 MirTarget;miRNATAP -0.351874736758691 4.04178074135551e-24 NA NA NA hsa-miR-21-3p TMEM47 2.17476065946878 5.15299442583591e-75 -2.06485952706021 1.44087411554797e-48 MirTarget -0.36643712339193 1.79938079159414e-21 NA NA NA hsa-miR-429 TMEM47 2.84108892259147 3.88520896426515e-64 -2.06485952706021 1.44087411554797e-48 miRanda -0.312039690518957 4.65299602755118e-30 NA NA NA hsa-miR-139-5p TMEM51 -3.25846663863766 2.62018989415003e-112 0.866468072942723 1.66233191709787e-25 miRanda -0.159484861176589 1.91035915069465e-20 NA NA NA hsa-miR-429 TMEM55A 2.84108892259147 3.88520896426515e-64 -1.18573123506325 2.12716797539133e-30 miRanda -0.222683209343148 8.04504917324536e-30 NA NA NA hsa-miR-183-5p TMEM56 2.95681814393872 1.09965777344285e-92 -0.879067538548105 5.53435751506619e-08 MirTarget -0.111577658001605 0.0011564864066815 NA NA NA hsa-miR-200b-3p TMEM56 2.11744072703209 1.66710572104191e-43 -0.879067538548105 5.53435751506619e-08 MirTarget -0.115622202652343 0.00081987693642058 NA NA NA hsa-miR-200c-3p TMEM56 2.07038651806183 6.84613386286599e-51 -0.879067538548105 5.53435751506619e-08 MirTarget -0.154954841586415 4.41688879430918e-05 NA NA NA hsa-miR-21-5p TMEM56 2.32007501846389 3.08394781855554e-137 -0.879067538548105 5.53435751506619e-08 miRNAWalker2_validate;mirMAP -0.421346454804842 3.02279529827395e-17 NA NA NA hsa-miR-139-5p TMEM57 -3.25846663863766 2.62018989415003e-112 0.53021164874044 4.20629159316765e-21 miRanda -0.101714892631942 1.84384551562411e-18 NA NA NA hsa-miR-335-5p TMEM63B -2.61355235628987 2.6462884165886e-51 1.29923335702364 1.44363692746293e-68 miRNAWalker2_validate -0.163550952976328 1.83829331321372e-29 NA NA NA hsa-miR-378a-5p TMEM63C -2.43173551693523 1.44932837789175e-68 1.98918881466188 1.66361465757866e-18 mirMAP -0.695249807352976 1.54076244174208e-44 NA NA NA hsa-miR-182-5p TMEM64 2.36408084103818 2.60011457600281e-72 -0.949019260857241 9.10326206641747e-10 MirTarget -0.229311268917849 5.52756309046906e-10 NA NA NA hsa-miR-429 TMEM64 2.84108892259147 3.88520896426515e-64 -0.949019260857241 9.10326206641747e-10 miRanda -0.173752729758828 3.48588505231522e-09 NA NA NA hsa-miR-139-5p TMEM68 -3.25846663863766 2.62018989415003e-112 0.36892452367246 7.2956630805171e-06 miRanda -0.107858454658295 1.48775377268308e-10 NA NA NA hsa-miR-335-5p TMEM8A -2.61355235628987 2.6462884165886e-51 1.38388892402711 2.94245071245139e-66 miRNAWalker2_validate -0.180652510591402 8.84247527424701e-31 NA NA NA hsa-miR-429 TMIE 2.84108892259147 3.88520896426515e-64 -1.64795902692943 4.29302396690581e-23 miRNATAP -0.163624457558635 3.93271965978358e-07 NA NA NA hsa-miR-182-5p TMOD1 2.36408084103818 2.60011457600281e-72 -1.9901091510424 9.95441065749206e-46 miRNATAP -0.349266418794636 3.30260162871974e-24 NA NA NA hsa-miR-429 TMOD1 2.84108892259147 3.88520896426515e-64 -1.9901091510424 9.95441065749206e-46 miRanda;miRNATAP -0.210732803622988 2.87962786729863e-14 NA NA NA hsa-miR-96-5p TMOD1 3.24596558166606 1.92296159041707e-98 -1.9901091510424 9.95441065749206e-46 miRNATAP -0.294587097381624 5.21037055294107e-25 NA NA NA hsa-miR-196a-5p TMOD2 2.33423717464504 3.646557504928e-18 -1.4675887064804 1.39009832495913e-37 miRNATAP -0.102590692513716 4.02999841839128e-12 NA NA NA hsa-miR-200a-5p TMOD2 2.58844508672328 1.79650654234569e-56 -1.4675887064804 1.39009832495913e-37 mirMAP -0.179529951151058 7.219760773566e-15 NA NA NA hsa-miR-429 TMOD2 2.84108892259147 3.88520896426515e-64 -1.4675887064804 1.39009832495913e-37 miRNATAP -0.187305146389783 4.69746629544855e-17 NA NA NA hsa-miR-139-5p TMPO -3.25846663863766 2.62018989415003e-112 0.48390549465565 5.37150125688001e-09 MirTarget;miRNATAP -0.138963110511376 2.07953427590276e-16 NA NA NA hsa-miR-335-5p TMPRSS13 -2.61355235628987 2.6462884165886e-51 0.8299588213164 5.96554849873615e-06 miRNAWalker2_validate -0.147168142167522 1.6146154187608e-05 NA NA NA hsa-miR-429 TMTC1 2.84108892259147 3.88520896426515e-64 -3.02667928145566 8.36117645373136e-53 miRanda -0.508303444481527 1.6389593022179e-40 NA NA NA hsa-miR-21-5p TMX4 2.32007501846389 3.08394781855554e-137 -0.369142115278296 3.2803699360771e-05 miRNAWalker2_validate;mirMAP -0.152867366054518 3.08441420379405e-08 NA NA NA hsa-miR-141-3p TNFAIP3 2.99777540204168 1.26370498493024e-78 -0.384684183147111 0.000748234816409438 TargetScan -0.132297814865696 1.95395162655108e-09 NA NA NA hsa-miR-429 TNFAIP3 2.84108892259147 3.88520896426515e-64 -0.384684183147111 0.000748234816409438 miRanda -0.102281354730575 2.1073153578897e-06 NA NA NA hsa-miR-182-5p TNFAIP8 2.36408084103818 2.60011457600281e-72 -0.686062928050401 7.55721883519595e-12 MirTarget -0.232675374081926 4.9734757415452e-23 NA NA NA hsa-miR-429 TNFAIP8 2.84108892259147 3.88520896426515e-64 -0.686062928050401 7.55721883519595e-12 miRNATAP -0.153860383306994 3.75431480570744e-16 NA NA NA hsa-miR-96-5p TNFAIP8 3.24596558166606 1.92296159041707e-98 -0.686062928050401 7.55721883519595e-12 TargetScan -0.18823734299647 6.51043335274677e-22 NA NA NA hsa-miR-378a-5p TNFAIP8L1 -2.43173551693523 1.44932837789175e-68 0.651953157367667 7.83436905181089e-15 MirTarget -0.111569289355405 5.69203174142421e-09 NA NA NA hsa-miR-183-5p TNFRSF11A 2.95681814393872 1.09965777344285e-92 -0.95226372638446 2.27495339699063e-11 mirMAP -0.213032504128925 1.23679449829412e-12 NA NA NA hsa-miR-200c-3p TNFRSF11B 2.07038651806183 6.84613386286599e-51 -0.837140585338879 5.84752838227966e-05 miRNATAP -0.223884434938994 4.07830474922777e-06 NA NA NA hsa-miR-21-5p TNFRSF11B 2.32007501846389 3.08394781855554e-137 -0.837140585338879 5.84752838227966e-05 miRNAWalker2_validate -0.242363243955373 0.000195848073067522 NA NA NA hsa-miR-429 TNFRSF11B 2.84108892259147 3.88520896426515e-64 -0.837140585338879 5.84752838227966e-05 PITA;miRanda;miRNATAP -0.144379336160906 0.000261883302871321 NA NA NA hsa-miR-429 TNFRSF1B 2.84108892259147 3.88520896426515e-64 -0.843214002710789 3.37305069739693e-14 miRNATAP -0.182346369305341 3.47551423170242e-18 NA NA NA hsa-miR-335-5p TNFRSF9 -2.61355235628987 2.6462884165886e-51 2.44287527835335 3.522510808492e-26 miRNAWalker2_validate -0.314362909267853 6.35644418883498e-13 NA NA NA hsa-miR-486-5p TNFRSF9 -3.87258704301474 1.22658629378451e-80 2.44287527835335 3.522510808492e-26 miRanda -0.258212313612783 4.99745410807822e-13 NA NA NA hsa-miR-139-5p TNFSF11 -3.25846663863766 2.62018989415003e-112 1.37069143668504 2.71655150955534e-09 miRanda -0.177045339024419 0.000213869424625636 NA NA NA hsa-miR-486-5p TNFSF11 -3.87258704301474 1.22658629378451e-80 1.37069143668504 2.71655150955534e-09 miRanda -0.227783410198534 7.57661762966584e-11 NA NA NA hsa-miR-429 TNFSF12 2.84108892259147 3.88520896426515e-64 -0.787013786687049 1.10280190891372e-22 miRanda -0.145922992262021 9.63314963359471e-22 NA NA NA hsa-miR-486-5p TNFSF4 -3.87258704301474 1.22658629378451e-80 1.69735293773867 1.98110676503508e-35 miRanda -0.196981084744437 1.49661139375515e-20 NA NA NA hsa-miR-375 TNIP3 2.09893673049766 1.68351780396203e-16 1.17140652530055 6.72791405262974e-07 miRanda -0.182148083397167 4.48000217714373e-09 NA NA NA hsa-miR-429 TNNI3K 2.84108892259147 3.88520896426515e-64 -2.14482499016799 3.58154065818387e-25 miRanda -0.268512466669934 1.85812301547719e-11 NA NA NA hsa-miR-335-5p TNNT2 -2.61355235628987 2.6462884165886e-51 -0.425745405362432 0.166549416395059 miRNAWalker2_validate -0.130707095258808 0.0223511796370352 NA NA NA hsa-miR-21-5p TNPO1 2.32007501846389 3.08394781855554e-137 -0.160565672363043 0.0117421748332371 miRNAWalker2_validate;mirMAP -0.101894159495048 2.4075932327283e-07 NA NA NA hsa-miR-21-3p TNRC6B 2.17476065946878 5.15299442583591e-75 -0.626372643112132 5.1226714000403e-20 mirMAP -0.105789294888126 6.88601698280536e-09 NA NA NA hsa-miR-21-5p TNRC6B 2.32007501846389 3.08394781855554e-137 -0.626372643112132 5.1226714000403e-20 miRNAWalker2_validate;miRNATAP -0.221568273286781 1.07896083121108e-25 NA NA NA hsa-miR-141-3p TNS1 2.99777540204168 1.26370498493024e-78 -2.87283202537718 5.47225880201927e-123 MirTarget;TargetScan -0.547321395184938 4.63833445319417e-116 NA NA NA hsa-miR-200a-3p TNS1 2.55218480823434 2.96135446816238e-51 -2.87283202537718 5.47225880201927e-123 MirTarget -0.446329981211595 1.07949671448638e-72 NA NA NA hsa-miR-96-5p TNS1 3.24596558166606 1.92296159041707e-98 -2.87283202537718 5.47225880201927e-123 TargetScan -0.504895247710553 6.0748484815984e-90 NA NA NA hsa-miR-141-3p TNS3 2.99777540204168 1.26370498493024e-78 -0.350351470632321 2.83318833184234e-05 MirTarget;TargetScan;miRNATAP -0.154380749259515 2.96503581653606e-22 NA NA NA hsa-miR-182-5p TNS3 2.36408084103818 2.60011457600281e-72 -0.350351470632321 2.83318833184234e-05 miRNATAP -0.142323837174963 5.71658516313222e-13 NA NA NA hsa-miR-200a-3p TNS3 2.55218480823434 2.96135446816238e-51 -0.350351470632321 2.83318833184234e-05 MirTarget;miRNATAP -0.146180367593977 9.19956142945461e-21 NA NA NA hsa-miR-96-5p TNS3 3.24596558166606 1.92296159041707e-98 -0.350351470632321 2.83318833184234e-05 MirTarget;TargetScan;miRNATAP -0.139001409645278 1.39848097206928e-17 NA NA NA hsa-miR-182-5p TNS4 2.36408084103818 2.60011457600281e-72 -1.4419293548893 3.52777304201814e-07 mirMAP -0.194063409667663 0.00428341416254633 NA NA NA hsa-miR-139-5p TOM1L1 -3.25846663863766 2.62018989415003e-112 0.704932194727521 7.70954564884351e-09 miRanda -0.117921496271111 2.99506242952792e-06 NA NA NA hsa-miR-141-3p TOM1L2 2.99777540204168 1.26370498493024e-78 -0.520667499227671 1.47555060196936e-09 TargetScan;miRNATAP -0.102869378558876 7.97330711179155e-10 NA NA NA hsa-miR-139-5p TOP1 -3.25846663863766 2.62018989415003e-112 0.466374239175647 1.59945021349553e-13 PITA;miRanda;miRNATAP -0.112601171612823 2.91401230934602e-18 NA NA NA hsa-miR-139-5p TOP1P1 -3.25846663863766 2.62018989415003e-112 0.5140589438737 2.23747104948617e-29 miRanda -0.106326855586635 7.70767169865707e-30 NA NA NA hsa-miR-139-5p TOP2A -3.25846663863766 2.62018989415003e-112 3.69231689105757 1.10945514814013e-83 miRanda -0.674640636377882 8.00111376870418e-63 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139 breast cancer hsa-miR-139-5p TOPBP1 -3.25846663863766 2.62018989415003e-112 0.319997750040363 6.70550969854157e-06 miRanda -0.104393110755358 5.85548873139202e-13 NA NA NA hsa-miR-21-5p TOPORS 2.32007501846389 3.08394781855554e-137 -0.40306059090145 7.76010916373138e-11 miRNAWalker2_validate -0.213687255984307 6.8590292232134e-30 NA NA NA hsa-miR-21-5p TOR1AIP2 2.32007501846389 3.08394781855554e-137 -0.000727158277626927 0.994480581747636 mirMAP -0.102442673178048 0.00173123353353528 NA NA NA hsa-miR-486-5p TOR2A -3.87258704301474 1.22658629378451e-80 1.23710419305096 1.78961795509186e-50 miRanda -0.115391085347618 1.4480414602867e-18 NA NA NA hsa-miR-182-5p TOX 2.36408084103818 2.60011457600281e-72 -0.769269609379691 5.3354162411304e-05 miRNATAP -0.364416239109958 4.01080336145008e-16 NA NA NA hsa-miR-429 TOX 2.84108892259147 3.88520896426515e-64 -0.769269609379691 5.3354162411304e-05 miRanda -0.161713195812124 7.39103268870096e-06 NA NA NA hsa-miR-96-5p TOX 3.24596558166606 1.92296159041707e-98 -0.769269609379691 5.3354162411304e-05 TargetScan;miRNATAP -0.31590661670591 1.61866323182775e-17 NA NA NA hsa-miR-429 TOX2 2.84108892259147 3.88520896426515e-64 -0.525954857899088 0.000241959441192088 miRNATAP -0.161383412568239 2.26992372758559e-09 NA NA NA hsa-miR-96-5p TOX2 3.24596558166606 1.92296159041707e-98 -0.525954857899088 0.000241959441192088 TargetScan -0.203123966997214 4.3946172269819e-13 NA NA NA hsa-miR-429 TP53AIP1 2.84108892259147 3.88520896426515e-64 -2.2838388592022 1.51820453099326e-24 miRNATAP -0.147733185224398 0.000691294477859294 NA NA NA hsa-miR-486-5p TP53INP1 -3.87258704301474 1.22658629378451e-80 0.722610414665271 5.79158974462484e-11 miRanda -0.109843791387951 5.90039121353124e-11 NA NA NA hsa-miR-141-3p TP63 2.99777540204168 1.26370498493024e-78 -3.22723602151797 5.78415028904247e-31 MirTarget -0.491288946265715 5.34967525764489e-19 NA NA NA hsa-miR-200a-3p TP63 2.55218480823434 2.96135446816238e-51 -3.22723602151797 5.78415028904247e-31 MirTarget -0.353907219678474 9.99717457803129e-11 NA NA NA hsa-miR-21-5p TP63 2.32007501846389 3.08394781855554e-137 -3.22723602151797 5.78415028904247e-31 miRNAWalker2_validate -0.557133918156164 4.86451790960546e-10 NA NA NA hsa-miR-429 TP63 2.84108892259147 3.88520896426515e-64 -3.22723602151797 5.78415028904247e-31 miRNATAP -0.415091558929633 1.64860778238223e-14 NA NA NA hsa-miR-335-5p TP73 -2.61355235628987 2.6462884165886e-51 0.496595627051834 0.00711519755707105 mirMAP -0.10921364812323 0.00145304472317377 NA NA NA hsa-miR-139-5p TPD52 -3.25846663863766 2.62018989415003e-112 1.84654087912303 6.8815294303493e-47 MirTarget;miRanda;miRNATAP -0.390299784717814 1.47795266359467e-49 NA NA NA hsa-miR-139-5p TPI1P2 -3.25846663863766 2.62018989415003e-112 0.768168141845771 2.23003738073663e-16 miRanda -0.154620949491066 1.11197276078715e-15 NA NA NA hsa-miR-96-5p TPM2 3.24596558166606 1.92296159041707e-98 -0.936136387975656 8.20735781654983e-11 TargetScan -0.246143596727655 2.93702965075941e-18 NA NA NA hsa-miR-139-5p TPM3 -3.25846663863766 2.62018989415003e-112 1.20094351262857 1.52351376875333e-75 PITA -0.206979683374448 2.70057175840023e-50 NA NA NA hsa-miR-145-5p TPM3 -2.62703571936687 7.64402900188551e-88 1.20094351262857 1.52351376875333e-75 miRNAWalker2_validate -0.199366546874454 8.34701725003177e-36 NA NA NA hsa-miR-21-5p TPRG1L 2.32007501846389 3.08394781855554e-137 -0.468556774717745 1.35411218900825e-16 miRNAWalker2_validate;MirTarget -0.18209864158624 1.51513313134975e-25 NA NA NA hsa-miR-429 TPST1 2.84108892259147 3.88520896426515e-64 -0.544616776174601 1.7358030432985e-09 miRanda -0.17363415436838 4.68270337179579e-25 NA NA NA hsa-miR-375 TPTE2P1 2.09893673049766 1.68351780396203e-16 -1.65341936749609 2.47777472989518e-23 miRanda -0.118231768261213 1.3137217747722e-07 NA NA NA hsa-miR-429 TPTE2P1 2.84108892259147 3.88520896426515e-64 -1.65341936749609 2.47777472989518e-23 miRanda -0.219757687444976 6.49250231269785e-12 NA NA NA hsa-miR-139-5p TRAF3IP3 -3.25846663863766 2.62018989415003e-112 0.852693142711364 1.86815535480314e-09 miRanda -0.104494249792378 0.000388817472844611 NA NA NA hsa-miR-429 TRAF6 2.84108892259147 3.88520896426515e-64 -0.693006487455714 8.36029646109838e-25 miRanda -0.100224938591585 9.10568402232155e-15 NA NA NA hsa-miR-139-5p TRAFD1 -3.25846663863766 2.62018989415003e-112 0.552591850965433 3.2105285287642e-23 miRanda -0.109163069597379 1.78885505210075e-21 NA NA NA hsa-miR-139-5p TRAIP -3.25846663863766 2.62018989415003e-112 1.35126176746698 1.2160427850013e-45 miRanda -0.282318829222666 4.57745620543231e-47 NA NA NA hsa-miR-429 TRAK2 2.84108892259147 3.88520896426515e-64 -0.490502072212601 5.41716712948401e-09 miRNATAP -0.107638583645917 1.20237886087141e-11 NA NA NA hsa-miR-511-5p TRAM1L1 -2.27545475897362 3.84085514050558e-36 0.238455332093468 0.0323872036595285 MirTarget -0.137339857358189 7.56194215374029e-12 NA NA NA hsa-miR-141-3p TRAM2 2.99777540204168 1.26370498493024e-78 -0.321344955137462 8.52325476310052e-06 MirTarget;TargetScan -0.138490815513452 4.89595532123783e-24 NA NA NA hsa-miR-200a-3p TRAM2 2.55218480823434 2.96135446816238e-51 -0.321344955137462 8.52325476310052e-06 MirTarget -0.136256145024944 3.59086277571307e-24 NA NA NA hsa-miR-96-5p TRAM2 3.24596558166606 1.92296159041707e-98 -0.321344955137462 8.52325476310052e-06 TargetScan -0.114576957754922 3.97592883151338e-16 NA NA NA hsa-miR-141-3p TRHDE 2.99777540204168 1.26370498493024e-78 -4.5651188211774 8.96847933550376e-61 MirTarget;TargetScan -0.882210380275507 9.37283822162336e-60 NA NA NA hsa-miR-200a-3p TRHDE 2.55218480823434 2.96135446816238e-51 -4.5651188211774 8.96847933550376e-61 MirTarget -0.72223464669766 3.84608591210662e-40 NA NA NA hsa-miR-200b-3p TRHDE 2.11744072703209 1.66710572104191e-43 -4.5651188211774 8.96847933550376e-61 MirTarget;TargetScan -0.765884739281711 2.68804356035911e-36 NA NA NA hsa-miR-200c-3p TRHDE 2.07038651806183 6.84613386286599e-51 -4.5651188211774 8.96847933550376e-61 MirTarget -0.969820580794507 4.01275370688948e-49 NA NA NA hsa-miR-429 TRHDE 2.84108892259147 3.88520896426515e-64 -4.5651188211774 8.96847933550376e-61 MirTarget;PITA;miRanda -0.717313984873633 3.84372204152205e-40 NA NA NA hsa-miR-335-5p TRIB3 -2.61355235628987 2.6462884165886e-51 1.77905762277412 1.6812095246445e-55 miRNAWalker2_validate -0.206424217119701 8.19244457509968e-21 NA NA NA hsa-miR-183-5p TRIM2 2.95681814393872 1.09965777344285e-92 -1.82935991153139 3.44821085419053e-31 miRNATAP -0.303495996544962 2.4868266718936e-19 NA NA NA hsa-miR-200b-3p TRIM2 2.11744072703209 1.66710572104191e-43 -1.82935991153139 3.44821085419053e-31 TargetScan -0.104488794967568 0.00260578116286237 NA NA NA hsa-miR-200c-3p TRIM2 2.07038651806183 6.84613386286599e-51 -1.82935991153139 3.44821085419053e-31 miRNATAP -0.160922462014355 2.36103337148741e-05 NA NA NA hsa-miR-21-5p TRIM2 2.32007501846389 3.08394781855554e-137 -1.82935991153139 3.44821085419053e-31 miRNAWalker2_validate;mirMAP;miRNATAP -0.506416520204349 1.77271267675961e-24 NA NA NA hsa-miR-429 TRIM2 2.84108892259147 3.88520896426515e-64 -1.82935991153139 3.44821085419053e-31 PITA;miRanda;miRNATAP -0.133604737628444 1.53626208370636e-05 NA NA NA hsa-miR-429 TRIM22 2.84108892259147 3.88520896426515e-64 -0.788115719208082 3.02429181164749e-12 miRanda -0.147479579487946 5.87171492826108e-12 NA NA NA hsa-miR-141-3p TRIM23 2.99777540204168 1.26370498493024e-78 -0.683201005926275 2.66644008303317e-19 MirTarget;TargetScan -0.12175947507209 2.3657294160518e-16 NA NA NA hsa-miR-200a-3p TRIM23 2.55218480823434 2.96135446816238e-51 -0.683201005926275 2.66644008303317e-19 MirTarget -0.107190333023802 2.29198715725505e-13 NA NA NA hsa-miR-200b-3p TRIM23 2.11744072703209 1.66710572104191e-43 -0.683201005926275 2.66644008303317e-19 MirTarget -0.111884543453949 6.590547797904e-12 NA NA NA hsa-miR-200c-3p TRIM23 2.07038651806183 6.84613386286599e-51 -0.683201005926275 2.66644008303317e-19 MirTarget -0.132015163835771 1.54228785996194e-13 NA NA NA hsa-miR-429 TRIM23 2.84108892259147 3.88520896426515e-64 -0.683201005926275 2.66644008303317e-19 MirTarget;miRanda -0.128080784030098 6.42077864565071e-19 NA NA NA hsa-miR-139-5p TRIM24 -3.25846663863766 2.62018989415003e-112 0.371282469688734 5.64451651956643e-08 miRanda -0.102676337280217 1.98986466198622e-13 NA NA NA hsa-miR-21-5p TRIM33 2.32007501846389 3.08394781855554e-137 -0.128540278966426 0.0625307965599013 miRNAWalker2_validate;miRNATAP -0.119721587344264 1.98149738948897e-08 NA NA NA hsa-miR-139-5p TRIM37 -3.25846663863766 2.62018989415003e-112 0.498886634388186 4.85987448515037e-09 miRanda -0.116843533951283 2.47096553345229e-11 NA NA NA hsa-miR-335-5p TRIM46 -2.61355235628987 2.6462884165886e-51 1.57091946369499 4.52325822001178e-23 mirMAP -0.195402738618061 7.63982390731787e-11 NA NA NA hsa-miR-429 TRIM6 2.84108892259147 3.88520896426515e-64 -0.612556163627504 1.55268066697575e-06 miRanda -0.176447045375383 1.77942210271003e-13 NA NA NA hsa-miR-139-5p TRIM62 -3.25846663863766 2.62018989415003e-112 0.791279709813191 8.0489791940078e-26 miRanda -0.104468670779656 3.89118955261525e-11 NA NA NA hsa-miR-21-3p TRIM66 2.17476065946878 5.15299442583591e-75 -0.663874615372167 4.04664998143094e-12 mirMAP -0.221282814675062 8.48837256285836e-19 NA NA NA hsa-miR-429 TRIM9 2.84108892259147 3.88520896426515e-64 -1.06054559711552 1.03435405953731e-08 PITA;miRanda;miRNATAP -0.135621407987902 0.000123692432581749 NA NA NA hsa-miR-96-5p TRIM9 3.24596558166606 1.92296159041707e-98 -1.06054559711552 1.03435405953731e-08 MirTarget;TargetScan -0.150861011220377 4.2542928831769e-05 NA NA NA hsa-miR-10b-5p TRMT61A -2.10996264627796 7.36811595736367e-72 0.594339068878865 9.08864945937052e-10 mirMAP -0.242910219212646 1.52247732388448e-21 NA NA NA hsa-miR-183-5p TRO 2.95681814393872 1.09965777344285e-92 -1.06494758479308 4.79421389704437e-17 miRNAWalker2_validate -0.293135150098507 1.02474634924926e-28 NA NA NA hsa-miR-429 TRO 2.84108892259147 3.88520896426515e-64 -1.06494758479308 4.79421389704437e-17 miRanda -0.222282981460835 1.71742810309871e-20 NA NA NA hsa-miR-183-5p TRPC6 2.95681814393872 1.09965777344285e-92 -1.69822837481065 2.3185333980348e-46 MirTarget -0.299351198803696 1.02727913334312e-31 NA NA NA hsa-miR-335-5p TRPM4 -2.61355235628987 2.6462884165886e-51 0.864835503554668 1.9869245681941e-14 miRNAWalker2_validate -0.101884201214736 1.61213263455531e-06 NA NA NA hsa-miR-182-5p TRPM6 2.36408084103818 2.60011457600281e-72 -3.03043627803069 1.81297760239146e-38 MirTarget -0.665019787703611 2.7494198012197e-32 NA NA NA hsa-miR-21-5p TRPM7 2.32007501846389 3.08394781855554e-137 -0.468634485811275 1.82192137886456e-10 miRNAWalker2_validate;miRNATAP -0.199895215552816 1.13560815427112e-18 NA NA NA hsa-miR-139-5p TRPS1 -3.25846663863766 2.62018989415003e-112 0.975779250773293 1.00018911688075e-11 miRanda -0.231534299412524 3.52435934805753e-15 NA NA NA hsa-miR-200b-3p TRPV3 2.11744072703209 1.66710572104191e-43 -1.18143944497478 1.90717583464061e-06 TargetScan -0.183113194318092 0.000533202771102452 NA NA NA hsa-miR-200c-3p TRPV3 2.07038651806183 6.84613386286599e-51 -1.18143944497478 1.90717583464061e-06 miRNATAP -0.161039585811955 0.00566754695485503 NA NA NA hsa-miR-429 TRPV3 2.84108892259147 3.88520896426515e-64 -1.18143944497478 1.90717583464061e-06 miRNATAP -0.110033189273818 0.0200110601269489 NA NA NA hsa-miR-200b-3p TSC22D1 2.11744072703209 1.66710572104191e-43 -0.769265226283634 1.08321730787095e-26 MirTarget;TargetScan -0.102611273301241 4.4511352619003e-11 NA NA NA hsa-miR-200c-3p TSC22D1 2.07038651806183 6.84613386286599e-51 -0.769265226283634 1.08321730787095e-26 MirTarget;miRNATAP -0.116865872245542 8.49008322011176e-12 NA NA NA hsa-miR-429 TSC22D1 2.84108892259147 3.88520896426515e-64 -0.769265226283634 1.08321730787095e-26 MirTarget;miRanda;miRNATAP -0.118921597109595 6.20879905061963e-18 NA NA NA hsa-miR-429 TSC22D3 2.84108892259147 3.88520896426515e-64 -0.54824265518886 3.00229686619098e-07 miRNATAP -0.172203264461262 7.45378992158275e-18 NA NA NA hsa-miR-96-5p TSC22D3 3.24596558166606 1.92296159041707e-98 -0.54824265518886 3.00229686619098e-07 TargetScan;miRNATAP -0.107392878955631 3.9713802021883e-07 NA NA NA hsa-miR-429 TSHR 2.84108892259147 3.88520896426515e-64 -1.8260290902974 2.30866772957347e-23 miRanda -0.241513367510784 8.02421549453637e-12 NA NA NA hsa-miR-21-5p TSHZ1 2.32007501846389 3.08394781855554e-137 -0.753487540537039 2.05836484515641e-20 miRNATAP -0.293670436231765 6.94877226450165e-32 NA NA NA hsa-miR-429 TSHZ1 2.84108892259147 3.88520896426515e-64 -0.753487540537039 2.05836484515641e-20 miRNATAP -0.107755967995349 4.78657323787575e-12 NA NA NA hsa-miR-182-5p TSHZ2 2.36408084103818 2.60011457600281e-72 -3.17391923475675 1.40654093537148e-60 miRNATAP -0.5645837331925 4.19593918784118e-32 NA NA NA hsa-miR-200a-5p TSHZ2 2.58844508672328 1.79650654234569e-56 -3.17391923475675 1.40654093537148e-60 mirMAP -0.405646098492993 1.35395085689322e-24 NA NA NA hsa-miR-429 TSHZ2 2.84108892259147 3.88520896426515e-64 -3.17391923475675 1.40654093537148e-60 miRanda -0.495748083299908 1.58033466138213e-39 NA NA NA hsa-miR-96-5p TSHZ2 3.24596558166606 1.92296159041707e-98 -3.17391923475675 1.40654093537148e-60 miRNATAP -0.610298069851615 1.09821640272076e-56 NA NA NA hsa-miR-141-3p TSHZ3 2.99777540204168 1.26370498493024e-78 -0.73282959487018 6.60562399903423e-11 MirTarget;TargetScan;miRNATAP -0.283434224716805 1.27966555313161e-41 NA NA NA hsa-miR-200a-3p TSHZ3 2.55218480823434 2.96135446816238e-51 -0.73282959487018 6.60562399903423e-11 MirTarget;miRNATAP -0.241748570999405 4.78092529696568e-31 NA NA NA hsa-miR-429 TSKU 2.84108892259147 3.88520896426515e-64 -0.38927561093109 0.0042375232744141 miRNATAP -0.112281704741328 1.2807857947815e-05 NA NA NA hsa-miR-511-5p TSPAN10 -2.27545475897362 3.84085514050558e-36 1.30958837495072 8.09034608716205e-13 MirTarget -0.219774821135261 4.89616735498579e-11 NA NA NA hsa-miR-182-5p TSPAN11 2.36408084103818 2.60011457600281e-72 -1.45285413814232 3.99090114003723e-22 mirMAP -0.420357427193568 1.32246126522149e-32 NA NA NA hsa-miR-183-5p TSPAN11 2.95681814393872 1.09965777344285e-92 -1.45285413814232 3.99090114003723e-22 mirMAP -0.377821733984323 1.03053650846492e-33 NA NA NA hsa-miR-429 TSPAN12 2.84108892259147 3.88520896426515e-64 -1.07983792156747 1.30501769088655e-13 miRanda -0.121119031817967 1.46902220764515e-05 NA NA NA hsa-miR-429 TSPAN18 2.84108892259147 3.88520896426515e-64 -0.820950989991295 4.77973952782263e-16 miRNATAP -0.214008805773193 5.95452873989423e-30 NA NA NA hsa-miR-21-3p TSPAN3 2.17476065946878 5.15299442583591e-75 -0.742644221409189 8.30301924177388e-17 MirTarget -0.164226831757255 3.70267569641525e-12 NA NA NA hsa-miR-10b-5p TSPAN33 -2.10996264627796 7.36811595736367e-72 0.479703406409117 3.46209253745526e-05 miRNAWalker2_validate -0.221743256394295 4.18271697507027e-13 NA NA NA hsa-miR-141-3p TSPAN4 2.99777540204168 1.26370498493024e-78 -0.587112707496993 4.37105941580206e-09 TargetScan -0.190772972993814 1.64489959254982e-23 NA NA NA hsa-miR-96-5p TSPAN4 3.24596558166606 1.92296159041707e-98 -0.587112707496993 4.37105941580206e-09 TargetScan -0.172127694409179 1.28675025410318e-18 NA NA NA hsa-miR-429 TSPYL2 2.84108892259147 3.88520896426515e-64 -0.764731419155719 8.75882137476231e-22 miRNATAP -0.108331132805466 1.40000278450203e-12 NA NA NA hsa-miR-335-5p TSTD1 -2.61355235628987 2.6462884165886e-51 1.33913071609597 1.08432207928285e-29 miRNAWalker2_validate -0.142588373302081 2.69998307651598e-10 NA NA NA hsa-miR-141-3p TTBK2 2.99777540204168 1.26370498493024e-78 -1.51507396028917 3.2070875074631e-25 MirTarget -0.266335225275997 1.2345387718611e-20 NA NA NA hsa-miR-141-5p TTBK2 2.38411349683216 4.56310582620282e-58 -1.51507396028917 3.2070875074631e-25 MirTarget -0.166419060498175 2.27077944662639e-07 NA NA NA hsa-miR-182-5p TTBK2 2.36408084103818 2.60011457600281e-72 -1.51507396028917 3.2070875074631e-25 mirMAP -0.214459319723564 1.65496650520796e-09 NA NA NA hsa-miR-200a-3p TTBK2 2.55218480823434 2.96135446816238e-51 -1.51507396028917 3.2070875074631e-25 MirTarget -0.238406608015847 2.66957487030803e-17 NA NA NA hsa-miR-429 TTBK2 2.84108892259147 3.88520896426515e-64 -1.51507396028917 3.2070875074631e-25 miRanda -0.266287458500978 1.06855679397361e-21 NA NA NA hsa-miR-337-3p TTC13 -2.14274617598363 2.70942896809734e-43 0.624036300063673 8.31485511427046e-18 MirTarget;PITA -0.129916298339762 1.1692010809474e-17 NA NA NA hsa-miR-429 TTC23 2.84108892259147 3.88520896426515e-64 -1.00832044250676 1.00048267323217e-32 miRanda -0.149375285938293 5.23137474612925e-20 NA NA NA hsa-miR-486-5p TTC23L -3.87258704301474 1.22658629378451e-80 0.270118991431474 0.130649122178966 miRanda -0.113551751980894 2.72824940811877e-05 NA NA NA hsa-miR-511-5p TTC23L -2.27545475897362 3.84085514050558e-36 0.270118991431474 0.130649122178966 MirTarget -0.237159981905848 1.45448774589674e-13 NA NA NA hsa-miR-141-3p TTC28 2.99777540204168 1.26370498493024e-78 -1.65844116125173 3.58098324297455e-63 TargetScan -0.340842707295731 7.89989938927947e-72 NA NA NA hsa-miR-182-5p TTC28 2.36408084103818 2.60011457600281e-72 -1.65844116125173 3.58098324297455e-63 miRNAWalker2_validate -0.264714634524528 9.1643614989e-27 NA NA NA hsa-miR-429 TTC28 2.84108892259147 3.88520896426515e-64 -1.65844116125173 3.58098324297455e-63 miRNATAP -0.293888291176763 3.22200280126303e-54 NA NA NA hsa-miR-141-5p TTC33 2.38411349683216 4.56310582620282e-58 -0.816894102497242 8.42479956181868e-34 MirTarget -0.121831828528512 1.91071408552355e-16 NA NA NA hsa-miR-200b-3p TTC33 2.11744072703209 1.66710572104191e-43 -0.816894102497242 8.42479956181868e-34 TargetScan -0.111694926392745 2.62082778940452e-14 NA NA NA hsa-miR-21-5p TTC33 2.32007501846389 3.08394781855554e-137 -0.816894102497242 8.42479956181868e-34 miRNAWalker2_validate -0.282581742421259 3.88747839795257e-42 NA NA NA hsa-miR-429 TTC33 2.84108892259147 3.88520896426515e-64 -0.816894102497242 8.42479956181868e-34 miRanda;miRNATAP -0.11302756869291 4.17501546544938e-18 NA NA NA hsa-miR-139-5p TTC39A -3.25846663863766 2.62018989415003e-112 1.75127730029576 1.95458566556964e-23 miRanda -0.227804884969181 6.31774338739892e-10 NA NA NA hsa-miR-224-5p TTC39A -2.22249420723892 1.07787949391113e-18 1.75127730029576 1.95458566556964e-23 mirMAP -0.276154991997567 5.82926518213187e-33 NA NA NA hsa-miR-10b-5p TTC7A -2.10996264627796 7.36811595736367e-72 -0.119849229102816 0.124913719301297 mirMAP -0.103947924831383 4.97936899327796e-07 NA NA NA hsa-miR-378a-5p TTC9 -2.43173551693523 1.44932837789175e-68 0.764111644650402 5.8015518873312e-11 mirMAP -0.258089039115036 3.46036313334219e-23 NA NA NA hsa-miR-139-5p TTK -3.25846663863766 2.62018989415003e-112 2.89352341653616 8.36295862849794e-61 miRanda -0.617617104777334 6.89212472369163e-66 NA NA NA hsa-miR-141-3p TTLL7 2.99777540204168 1.26370498493024e-78 -1.14660093900781 4.12921497375204e-09 MirTarget;TargetScan -0.239965832625743 2.45594828259806e-10 NA NA NA hsa-miR-200a-3p TTLL7 2.55218480823434 2.96135446816238e-51 -1.14660093900781 4.12921497375204e-09 MirTarget -0.219896502995049 3.56866012725551e-09 NA NA NA hsa-miR-200a-5p TTLL7 2.58844508672328 1.79650654234569e-56 -1.14660093900781 4.12921497375204e-09 mirMAP -0.159979131442142 3.01566807201269e-05 NA NA NA hsa-miR-429 TTLL7 2.84108892259147 3.88520896426515e-64 -1.14660093900781 4.12921497375204e-09 miRanda -0.166873556345357 7.09059134505212e-06 NA NA NA hsa-miR-429 TTN 2.84108892259147 3.88520896426515e-64 -1.41593689755034 1.26361922023455e-29 miRanda -0.215596599927772 3.50663480822275e-19 NA NA NA hsa-miR-141-3p TTYH2 2.99777540204168 1.26370498493024e-78 -0.651069390632769 1.95664259540559e-09 TargetScan;miRNATAP -0.161556429800192 1.29736653314157e-14 NA NA NA hsa-miR-200a-3p TTYH2 2.55218480823434 2.96135446816238e-51 -0.651069390632769 1.95664259540559e-09 miRNATAP -0.164568131662886 1.12630590978141e-15 NA NA NA hsa-miR-141-5p TUB 2.38411349683216 4.56310582620282e-58 -1.37752229275216 1.66737985030413e-20 mirMAP -0.21059041712337 7.30950357361172e-11 NA NA NA hsa-miR-183-5p TUB 2.95681814393872 1.09965777344285e-92 -1.37752229275216 1.66737985030413e-20 MirTarget -0.289215158616154 2.65379884306093e-20 NA NA NA hsa-miR-96-5p TUB 3.24596558166606 1.92296159041707e-98 -1.37752229275216 1.66737985030413e-20 mirMAP -0.269104963382851 5.57540552669908e-20 NA NA NA hsa-miR-10b-5p TUBA1B -2.10996264627796 7.36811595736367e-72 0.818097125882405 2.66331986637191e-34 miRNAWalker2_validate -0.239386681697875 8.20139329673188e-42 NA NA NA hsa-miR-200c-3p TUBB2A 2.07038651806183 6.84613386286599e-51 -0.593966447842469 2.37131788141525e-07 MirTarget;miRNATAP -0.162306818074891 1.3159105360671e-09 NA NA NA hsa-miR-99a-5p TUBG1 -2.25079447371102 1.14086813185885e-54 1.0169669508041 1.28273014244032e-36 miRNAWalker2_validate -0.265958573161758 2.31791491097151e-52 NA NA NA hsa-miR-378a-5p TUSC2 -2.43173551693523 1.44932837789175e-68 0.304681584414283 8.800050287598e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.126892578672219 3.12769788594813e-20 NA NA NA hsa-miR-96-5p TWIST1 3.24596558166606 1.92296159041707e-98 -1.33829446184742 4.11586388271804e-17 TargetScan -0.359569754082565 2.99943599811125e-31 NA NA NA hsa-miR-139-5p TXNDC17 -3.25846663863766 2.62018989415003e-112 1.03223729641314 1.50245845188525e-40 miRanda -0.20133810351741 3.59018068445859e-36 NA NA NA hsa-miR-378a-5p TXNDC17 -2.43173551693523 1.44932837789175e-68 1.03223729641314 1.50245845188525e-40 MirTarget -0.129055187149129 1.29653678246465e-12 NA NA NA hsa-miR-141-3p TXNIP 2.99777540204168 1.26370498493024e-78 -2.1278383158488 8.14661112419651e-76 MirTarget -0.370028098915553 2.38007344541804e-58 NA NA NA hsa-miR-183-5p TXNIP 2.95681814393872 1.09965777344285e-92 -2.1278383158488 8.14661112419651e-76 miRNAWalker2_validate -0.397158945889229 4.8382182119328e-57 NA NA NA hsa-miR-200a-3p TXNIP 2.55218480823434 2.96135446816238e-51 -2.1278383158488 8.14661112419651e-76 MirTarget -0.277572731123545 1.06886008509125e-32 NA NA NA hsa-miR-99a-5p TYMS -2.25079447371102 1.14086813185885e-54 2.11597627848989 5.39403616421542e-55 miRNAWalker2_validate -0.401033410918093 4.6336327053165e-39 NA NA NA hsa-miR-141-3p UACA 2.99777540204168 1.26370498493024e-78 -0.950369501657328 4.25857257062218e-39 TargetScan -0.185553686719098 1.80726170106575e-39 NA NA NA hsa-miR-429 UACA 2.84108892259147 3.88520896426515e-64 -0.950369501657328 4.25857257062218e-39 miRanda -0.167748362332289 9.98832344348932e-34 NA NA NA hsa-miR-139-5p UBAP2L -3.25846663863766 2.62018989415003e-112 0.753459645403653 4.94834101779593e-42 miRanda -0.154380432214732 9.86430170019082e-42 NA NA NA hsa-miR-182-5p UBASH3B 2.36408084103818 2.60011457600281e-72 -0.136167524835324 0.319547711244032 MirTarget -0.220165634854557 8.09505889299283e-12 NA NA NA hsa-miR-99a-5p UBB -2.25079447371102 1.14086813185885e-54 0.326642508491664 1.55963501168835e-07 miRNAWalker2_validate -0.110117421999037 6.55893953014141e-16 NA NA NA hsa-miR-335-5p UBD -2.61355235628987 2.6462884165886e-51 0.862748226865875 0.00110339433470396 miRNAWalker2_validate -0.124932915391245 0.0112214464423294 NA NA NA hsa-miR-375 UBD 2.09893673049766 1.68351780396203e-16 0.862748226865875 0.00110339433470396 miRanda -0.207354049769643 2.23717504127829e-09 NA NA NA hsa-miR-375 UBE2E2 2.09893673049766 1.68351780396203e-16 -0.604529909585251 4.8825731116358e-09 miRanda -0.141119619746878 3.51026407192711e-26 NA NA NA hsa-miR-139-5p UBE2F -3.25846663863766 2.62018989415003e-112 0.66240452664349 1.31245686804503e-22 MirTarget;miRanda;miRNATAP -0.113299035342375 7.62479343859542e-16 NA NA NA hsa-miR-10b-5p UBE2I -2.10996264627796 7.36811595736367e-72 0.706188831113255 2.34638986365957e-41 MirTarget -0.153529180600688 3.26076836832234e-27 NA NA NA hsa-miR-486-5p UBE2S -3.87258704301474 1.22658629378451e-80 2.47687215721584 4.89818021457459e-69 miRanda -0.209978944831566 4.1833836366834e-20 NA NA NA hsa-miR-139-5p UBE2Z -3.25846663863766 2.62018989415003e-112 0.531416701885103 1.79902342102429e-16 miRanda -0.111303974163804 4.87309219890486e-17 NA NA NA hsa-miR-452-5p UBE3A -2.48486455572568 1.24430987974325e-33 -0.0419304645075087 0.546406918419685 MirTarget -0.103625192387646 9.34123415564561e-22 NA NA NA hsa-miR-21-5p UBE4A 2.32007501846389 3.08394781855554e-137 -0.397329554153248 7.36997071616709e-11 MirTarget;miRNATAP -0.168760265780093 2.63068843528021e-19 NA NA NA hsa-miR-429 UBR1 2.84108892259147 3.88520896426515e-64 -0.49013901909578 2.9703988578154e-08 miRanda;miRNATAP -0.121882993069234 2.43298455500529e-13 NA NA NA hsa-miR-21-5p UBR3 2.32007501846389 3.08394781855554e-137 -0.682148115948996 9.46916242897379e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.294363758773514 5.80124674467305e-36 NA NA NA hsa-miR-452-5p UBXN10 -2.48486455572568 1.24430987974325e-33 0.120437741779328 0.568915664613989 mirMAP -0.385881289717446 1.49659221274655e-32 NA NA NA hsa-miR-200b-3p UBXN7 2.11744072703209 1.66710572104191e-43 -0.613443672996766 2.02580451264322e-07 TargetScan;mirMAP -0.103286193982759 3.98531227124601e-05 NA NA NA hsa-miR-139-5p UCK2 -3.25846663863766 2.62018989415003e-112 0.914143618494481 3.49042417870193e-24 miRanda -0.228128999762966 9.60124854358488e-36 NA NA NA hsa-miR-139-5p UGT3A2 -3.25846663863766 2.62018989415003e-112 0.35864839842133 0.180555666925076 miRanda -0.184323192311511 0.000818409498833829 NA NA NA hsa-miR-21-5p UHMK1 2.32007501846389 3.08394781855554e-137 -0.304671278307886 0.114156168998821 mirMAP -0.222415346334735 0.000210223419522674 NA NA NA hsa-miR-429 UHMK1 2.84108892259147 3.88520896426515e-64 -0.304671278307886 0.114156168998821 miRNATAP -0.102915988723903 0.00484159825153219 NA NA NA hsa-miR-10b-5p UHRF1 -2.10996264627796 7.36811595736367e-72 3.81726615419535 1.18929553786585e-111 miRNAWalker2_validate -0.845410272713726 4.86422021748605e-70 NA NA NA hsa-miR-139-5p UHRF1 -3.25846663863766 2.62018989415003e-112 3.81726615419535 1.18929553786585e-111 miRanda -0.709783984950951 1.21465648728942e-85 NA NA NA hsa-miR-486-5p UMODL1 -3.87258704301474 1.22658629378451e-80 2.20953817598023 1.66540540122307e-16 miRanda -0.357383190380749 1.54918790618221e-18 NA NA NA hsa-miR-145-5p UNC13A -2.62703571936687 7.64402900188551e-88 1.98359819710959 1.82329897801348e-18 mirMAP -0.251467798441492 2.58963752109121e-06 NA NA NA hsa-miR-378a-5p UNC13A -2.43173551693523 1.44932837789175e-68 1.98359819710959 1.82329897801348e-18 mirMAP -0.140402866630944 0.00733571740279198 NA NA NA hsa-miR-335-5p UNC13D -2.61355235628987 2.6462884165886e-51 0.858600956034577 4.22232526499263e-08 miRNAWalker2_validate -0.168526106438831 7.08562791156285e-09 NA NA NA hsa-miR-144-5p UNC5B -2.75914786146772 1.55794225315972e-50 1.77795969869856 2.08395890257159e-54 mirMAP -0.178520477825364 1.58708225310143e-17 NA NA NA hsa-miR-335-5p UNC5B -2.61355235628987 2.6462884165886e-51 1.77795969869856 2.08395890257159e-54 mirMAP -0.260133598776787 1.55579069033265e-32 NA NA NA hsa-miR-378a-5p UNC5B -2.43173551693523 1.44932837789175e-68 1.77795969869856 2.08395890257159e-54 mirMAP -0.295017542134178 4.37375926100328e-28 NA NA NA hsa-miR-141-3p UNC5C 2.99777540204168 1.26370498493024e-78 -1.39702927654382 2.18325905910281e-12 MirTarget;TargetScan -0.303226133260993 3.93037191707908e-15 NA NA NA hsa-miR-182-5p UNC5C 2.36408084103818 2.60011457600281e-72 -1.39702927654382 2.18325905910281e-12 mirMAP -0.225437735162613 2.4729291492571e-06 NA NA NA hsa-miR-200a-3p UNC5C 2.55218480823434 2.96135446816238e-51 -1.39702927654382 2.18325905910281e-12 MirTarget -0.246863233283842 9.03019066185357e-11 NA NA NA hsa-miR-429 UNC5C 2.84108892259147 3.88520896426515e-64 -1.39702927654382 2.18325905910281e-12 miRNATAP -0.271359267389839 6.24428446577313e-13 NA NA NA hsa-miR-96-5p UNC5C 3.24596558166606 1.92296159041707e-98 -1.39702927654382 2.18325905910281e-12 mirMAP -0.304930206688324 8.15751291648178e-15 NA NA NA hsa-miR-21-5p UNC80 2.32007501846389 3.08394781855554e-137 -0.66942265044781 0.00637448012523831 MirTarget -0.363774902177116 1.84904351115534e-06 NA NA NA hsa-miR-335-5p UNC93B1 -2.61355235628987 2.6462884165886e-51 1.05757898374824 9.82616769882934e-29 miRNAWalker2_validate -0.146611043449202 3.43327726054313e-16 NA NA NA hsa-miR-99a-5p UQCR10 -2.25079447371102 1.14086813185885e-54 0.594769039167331 6.68943533588634e-14 miRNAWalker2_validate -0.155939644953526 4.29122635856206e-19 NA NA NA hsa-miR-10b-5p USF2 -2.10996264627796 7.36811595736367e-72 0.554382599687189 4.21037165132301e-14 miRNATAP -0.18646936506526 5.68215811879695e-22 NA NA NA hsa-miR-429 USP12 2.84108892259147 3.88520896426515e-64 -0.852124745832273 3.09341844333372e-10 miRanda;miRNATAP -0.143502066606246 2.47865272426449e-08 NA NA NA hsa-miR-139-5p USP14 -3.25846663863766 2.62018989415003e-112 0.458422037196657 6.51375740017917e-09 miRanda -0.107386203914547 3.54818841558527e-11 NA NA NA hsa-miR-21-5p USP34 2.32007501846389 3.08394781855554e-137 -0.472959984938134 3.83583824677013e-13 miRNAWalker2_validate -0.196058475100826 1.31129212224992e-22 NA NA NA hsa-miR-21-3p USP44 2.17476065946878 5.15299442583591e-75 -3.27162340833679 1.27337367856023e-62 MirTarget -0.495846852348094 1.1047057848864e-19 NA NA NA hsa-miR-21-5p USP47 2.32007501846389 3.08394781855554e-137 -0.372974919273745 5.54498664879749e-11 miRNAWalker2_validate -0.169271433383096 2.9631118519651e-22 NA NA NA hsa-miR-21-3p USP51 2.17476065946878 5.15299442583591e-75 -0.932919794110664 3.33060498274186e-14 MirTarget -0.15724719757217 1.57121240454448e-06 NA NA NA hsa-miR-141-3p USP53 2.99777540204168 1.26370498493024e-78 -1.49116967272135 3.36605167840143e-42 TargetScan -0.211991882585796 3.39646673159852e-22 NA NA NA hsa-miR-429 USP53 2.84108892259147 3.88520896426515e-64 -1.49116967272135 3.36605167840143e-42 miRanda -0.183087441882495 1.41049967456404e-17 NA NA NA hsa-miR-375 UST 2.09893673049766 1.68351780396203e-16 -1.71001908778866 1.23028866163774e-33 miRNATAP -0.125447918823378 7.23795781717571e-11 NA NA NA hsa-miR-21-5p UTRN 2.32007501846389 3.08394781855554e-137 -1.76529417295337 2.72322350747854e-55 miRNAWalker2_validate -0.470139987933755 3.6427348192286e-39 NA NA NA hsa-miR-182-5p VAMP3 2.36408084103818 2.60011457600281e-72 -0.736995083003446 1.00030025393281e-51 MirTarget;miRNATAP -0.113396468140509 5.17073244414246e-21 NA NA NA hsa-miR-96-5p VAMP3 3.24596558166606 1.92296159041707e-98 -0.736995083003446 1.00030025393281e-51 TargetScan;miRNATAP -0.118076182064917 3.8105370111567e-33 NA NA NA hsa-miR-130a-3p VANGL1 -1.15024914519431 6.51290317952496e-19 0.830758894468949 1.66153518153183e-24 mirMAP -0.13320016720032 5.81451951775816e-10 NA NA NA hsa-miR-139-5p VANGL1 -3.25846663863766 2.62018989415003e-112 0.830758894468949 1.66153518153183e-24 miRanda -0.161777639176173 6.00227916383558e-22 NA NA NA hsa-miR-195-5p VANGL1 -1.47508108420708 2.20685847368258e-38 0.830758894468949 1.66153518153183e-24 mirMAP -0.234198291882211 1.61785278026182e-23 NA NA NA hsa-miR-214-3p VANGL1 -0.523705501275844 0.000211299789901139 0.830758894468949 1.66153518153183e-24 mirMAP -0.137565470387465 8.31314037723104e-12 NA NA NA hsa-miR-218-5p VANGL1 -1.02621788318234 2.9221925445771e-23 0.830758894468949 1.66153518153183e-24 mirMAP -0.227997550601069 9.78752605670574e-18 NA NA NA hsa-miR-26a-5p VANGL1 -0.481180084102235 1.82368246174758e-10 0.830758894468949 1.66153518153183e-24 mirMAP -0.376690599739968 1.73365456652659e-24 NA NA NA hsa-miR-320a VANGL1 -0.287921276129346 0.00141693637596294 0.830758894468949 1.66153518153183e-24 mirMAP -0.136314967525611 1.82491693402936e-05 NA NA NA hsa-miR-378c VANGL1 -1.79697571999492 1.07363220292403e-41 0.830758894468949 1.66153518153183e-24 miRNATAP -0.13496008439357 3.32243434568058e-11 NA NA NA hsa-miR-485-3p VANGL1 -0.866822427729628 4.5194665263492e-11 0.830758894468949 1.66153518153183e-24 mirMAP -0.112215433433973 2.23086646351406e-07 NA NA NA hsa-miR-185-5p VANGL2 0.482334746589337 3.68475879959415e-09 0.213526720331232 0.294980987619079 MirTarget -0.18480243983042 0.0304060015816039 NA NA NA hsa-miR-30d-5p VANGL2 -0.247082219011045 0.00406717930063148 0.213526720331232 0.294980987619079 mirMAP -0.180745549789828 0.0270109717918775 NA NA NA hsa-miR-589-5p VANGL2 0.367182541239722 1.67804815542873e-05 0.213526720331232 0.294980987619079 mirMAP -0.202426378713681 0.0137114280708807 NA NA NA hsa-miR-7-1-3p VANGL2 0.686579567507582 1.20731554448806e-07 0.213526720331232 0.294980987619079 mirMAP -0.142492068299119 0.00779650628148012 NA NA NA hsa-miR-183-5p VASH1 2.95681814393872 1.09965777344285e-92 -0.0383472405570258 0.657089178226667 mirMAP -0.112198340900979 4.62952530075591e-10 NA NA NA hsa-miR-200c-3p VASH1 2.07038651806183 6.84613386286599e-51 -0.0383472405570258 0.657089178226667 MirTarget;miRNATAP -0.144847192398297 2.90101239756295e-13 NA NA NA hsa-miR-182-5p VAT1L 2.36408084103818 2.60011457600281e-72 -1.42983088580135 2.75386157340812e-14 miRNATAP -0.429641609292392 3.61229948842033e-22 NA NA NA hsa-miR-200b-3p VAT1L 2.11744072703209 1.66710572104191e-43 -1.42983088580135 2.75386157340812e-14 MirTarget;TargetScan -0.303491736681768 2.90408835363678e-14 NA NA NA hsa-miR-200c-3p VAT1L 2.07038651806183 6.84613386286599e-51 -1.42983088580135 2.75386157340812e-14 MirTarget;miRNATAP -0.399013122726224 5.23239500429498e-20 NA NA NA hsa-miR-375 VAT1L 2.09893673049766 1.68351780396203e-16 -1.42983088580135 2.75386157340812e-14 miRNATAP -0.191580517630145 1.14036359433398e-14 NA NA NA hsa-miR-429 VAT1L 2.84108892259147 3.88520896426515e-64 -1.42983088580135 2.75386157340812e-14 MirTarget;miRanda;miRNATAP -0.231693034439561 9.84706397273985e-11 NA NA NA hsa-miR-96-5p VAT1L 3.24596558166606 1.92296159041707e-98 -1.42983088580135 2.75386157340812e-14 TargetScan;miRNATAP -0.341925138931076 1.9559223422504e-20 NA NA NA hsa-miR-335-5p VAV2 -2.61355235628987 2.6462884165886e-51 1.1965966856055 8.41260380777138e-67 mirMAP;miRNATAP -0.150104572745055 1.30269206535334e-28 NA NA NA hsa-miR-511-5p VAV3 -2.27545475897362 3.84085514050558e-36 1.34411719441904 1.087241773222e-13 MirTarget -0.280152249700283 1.3763003979029e-17 NA NA NA hsa-miR-200a-3p VCAM1 2.55218480823434 2.96135446816238e-51 -0.422080444805657 0.00361929851720551 miRNAWalker2_validate -0.192217611764734 2.18432689837879e-12 NA NA NA hsa-miR-200a-3p VCAN 2.55218480823434 2.96135446816238e-51 1.40978286772495 4.56459858126373e-18 MirTarget;miRNATAP -0.114795253898198 0.000286385738872126 NA NA NA hsa-miR-182-5p VCL 2.36408084103818 2.60011457600281e-72 -0.799778526692819 2.643223126547e-23 miRNATAP -0.176593003893063 4.56278352245587e-20 NA NA NA hsa-miR-429 VCL 2.84108892259147 3.88520896426515e-64 -0.799778526692819 2.643223126547e-23 miRNATAP -0.132211809985351 6.96553207154536e-18 NA NA NA hsa-miR-96-5p VCL 3.24596558166606 1.92296159041707e-98 -0.799778526692819 2.643223126547e-23 TargetScan;miRNATAP -0.165238662954859 2.02919680988792e-25 NA NA NA hsa-miR-139-5p VDAC1 -3.25846663863766 2.62018989415003e-112 0.63186596773093 1.93253018062742e-23 miRanda -0.144240388007721 7.14711593808498e-29 NA NA NA hsa-miR-335-5p VEGFA -2.61355235628987 2.6462884165886e-51 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.103950468396491 4.59347799365143e-08 NA NA NA hsa-miR-452-5p VEZT -2.48486455572568 1.24430987974325e-33 0.181406259391838 0.0056683713856385 MirTarget -0.108713887257831 9.1553293093637e-27 NA NA NA hsa-miR-182-5p VGLL3 2.36408084103818 2.60011457600281e-72 -2.09691663808755 1.44457964531322e-38 miRNATAP -0.433851817304504 1.04673252316086e-28 NA NA NA hsa-miR-200b-3p VGLL3 2.11744072703209 1.66710572104191e-43 -2.09691663808755 1.44457964531322e-38 mirMAP -0.405161046893378 1.16996761884778e-31 NA NA NA hsa-miR-200c-3p VGLL3 2.07038651806183 6.84613386286599e-51 -2.09691663808755 1.44457964531322e-38 mirMAP -0.489399000934698 1.6719482694344e-38 NA NA NA hsa-miR-429 VGLL3 2.84108892259147 3.88520896426515e-64 -2.09691663808755 1.44457964531322e-38 PITA;mirMAP;miRNATAP -0.34667849904768 5.1675564815212e-29 NA NA NA hsa-miR-96-5p VGLL3 3.24596558166606 1.92296159041707e-98 -2.09691663808755 1.44457964531322e-38 TargetScan;miRNATAP -0.425462292324359 1.25627259749834e-40 NA NA NA hsa-miR-182-5p VLDLR 2.36408084103818 2.60011457600281e-72 -1.77227581372422 1.67512075345855e-32 MirTarget;miRNATAP -0.313303185028531 6.27510775834438e-18 NA NA NA hsa-miR-200b-3p VLDLR 2.11744072703209 1.66710572104191e-43 -1.77227581372422 1.67512075345855e-32 TargetScan -0.314691879127484 1.17172322744022e-22 NA NA NA hsa-miR-200c-3p VLDLR 2.07038651806183 6.84613386286599e-51 -1.77227581372422 1.67512075345855e-32 miRNATAP -0.363293932443391 6.00658962928933e-25 NA NA NA hsa-miR-429 VLDLR 2.84108892259147 3.88520896426515e-64 -1.77227581372422 1.67512075345855e-32 PITA;miRanda;miRNATAP -0.264105744382496 4.50828353864825e-20 NA NA NA hsa-miR-96-5p VLDLR 3.24596558166606 1.92296159041707e-98 -1.77227581372422 1.67512075345855e-32 TargetScan;miRNATAP -0.252204940481474 6.32737179830321e-17 NA NA NA hsa-miR-335-5p VMO1 -2.61355235628987 2.6462884165886e-51 1.2656717513236 1.23254810801143e-12 miRNAWalker2_validate -0.254667455360358 1.35950509100943e-14 NA NA NA hsa-miR-21-5p VPS13A 2.32007501846389 3.08394781855554e-137 -0.753944090237763 2.81980541318011e-14 miRNAWalker2_validate -0.284157950575656 1.94094414412145e-20 NA NA NA hsa-miR-21-5p VPS13B 2.32007501846389 3.08394781855554e-137 -0.128944693117492 0.174938119035302 mirMAP -0.119463943041318 5.19837809674789e-05 NA NA NA hsa-miR-429 VPS13C 2.84108892259147 3.88520896426515e-64 -0.978759850191012 3.06785962593614e-20 miRanda -0.183663583701603 7.68426162397301e-20 NA NA NA hsa-miR-21-3p VPS13D 2.17476065946878 5.15299442583591e-75 -0.804733095475749 3.50669376394381e-28 MirTarget -0.140897430091744 7.24628435835847e-13 NA NA NA hsa-miR-21-5p VPS26A 2.32007501846389 3.08394781855554e-137 -0.165878219636764 0.00113445798041237 miRNAWalker2_validate -0.102820257316725 5.79628755566504e-11 NA NA NA hsa-miR-21-5p VPS36 2.32007501846389 3.08394781855554e-137 -0.747412798487835 1.29870355006609e-30 miRNAWalker2_validate -0.254135515722118 1.05894378025598e-36 NA NA NA hsa-miR-21-5p VPS53 2.32007501846389 3.08394781855554e-137 -0.230090323305044 3.78550564592848e-06 mirMAP -0.115212328214368 5.42397385050431e-14 NA NA NA hsa-miR-21-5p VPS54 2.32007501846389 3.08394781855554e-137 -0.252252567780012 0.000115071144123165 miRNAWalker2_validate -0.17377178401262 3.93322016702974e-18 NA NA NA hsa-miR-144-5p VSIG1 -2.75914786146772 1.55794225315972e-50 1.1967074018817 9.12332292001901e-12 MirTarget -0.133626978503687 1.49915712901318e-05 NA NA NA hsa-miR-486-5p VSIG1 -3.87258704301474 1.22658629378451e-80 1.1967074018817 9.12332292001901e-12 miRanda -0.128562875999891 1.73632784609199e-06 NA NA NA hsa-miR-429 VSNL1 2.84108892259147 3.88520896426515e-64 -1.16811921852226 1.22536881204956e-07 miRanda;miRNATAP -0.110275285623293 0.00890441724236124 NA NA NA hsa-miR-335-5p VSTM2L -2.61355235628987 2.6462884165886e-51 1.7944874677422 9.81742886674026e-12 miRNAWalker2_validate;mirMAP -0.267589545286262 5.65637679733169e-08 NA NA NA hsa-miR-486-5p VTCN1 -3.87258704301474 1.22658629378451e-80 -0.378114638741501 0.264299272622426 MirTarget;miRanda -0.195516750902276 0.000140356437335746 NA NA NA hsa-miR-486-5p VWA2 -3.87258704301474 1.22658629378451e-80 0.190066945085011 0.480530968376211 miRanda -0.152259103891575 0.000192895736398849 NA NA NA hsa-miR-429 VWF 2.84108892259147 3.88520896426515e-64 -2.03096525307727 9.93612805244949e-62 miRNATAP -0.368905568901854 5.44840907856256e-56 NA NA NA hsa-miR-200b-3p WASF1 2.11744072703209 1.66710572104191e-43 -0.678475233936717 7.60607099773565e-07 TargetScan -0.154713851640072 1.06487816140692e-07 NA NA NA hsa-miR-200c-3p WASF1 2.07038651806183 6.84613386286599e-51 -0.678475233936717 7.60607099773565e-07 miRNATAP -0.128457054878815 6.36546774218895e-05 NA NA NA hsa-miR-182-5p WASF2 2.36408084103818 2.60011457600281e-72 -0.82560441586991 1.0108866366432e-37 mirMAP;miRNATAP -0.13857816052844 1.10827519647818e-18 NA NA NA hsa-miR-96-5p WASF2 3.24596558166606 1.92296159041707e-98 -0.82560441586991 1.0108866366432e-37 TargetScan;miRNATAP -0.123472094738435 1.91025513007377e-21 NA NA NA hsa-miR-200a-3p WASF3 2.55218480823434 2.96135446816238e-51 -2.52846175739233 2.89361416346383e-58 miRNAWalker2_validate;miRTarBase -0.405908608720436 7.8748305448137e-40 NA NA NA hsa-miR-200b-3p WASF3 2.11744072703209 1.66710572104191e-43 -2.52846175739233 2.89361416346383e-58 miRNAWalker2_validate;miRTarBase;TargetScan -0.426347852136764 2.62441563344211e-35 NA NA NA hsa-miR-200c-3p WASF3 2.07038651806183 6.84613386286599e-51 -2.52846175739233 2.89361416346383e-58 miRNATAP -0.459350727713875 7.74115548172737e-34 NA NA NA hsa-miR-21-3p WASF3 2.17476065946878 5.15299442583591e-75 -2.52846175739233 2.89361416346383e-58 mirMAP -0.354865069189806 5.20238773950118e-16 NA NA NA hsa-miR-429 WASF3 2.84108892259147 3.88520896426515e-64 -2.52846175739233 2.89361416346383e-58 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.383670076769724 6.98450757369644e-36 NA NA NA hsa-miR-429 WBP2NL 2.84108892259147 3.88520896426515e-64 -0.965377735308097 1.34439382004263e-09 miRanda -0.107178306494458 0.000427168725491381 NA NA NA hsa-miR-429 WBSCR17 2.84108892259147 3.88520896426515e-64 -1.7234543507131 2.57167397084188e-17 miRNATAP -0.236689844738892 1.31669235039137e-09 NA NA NA hsa-miR-141-3p WDFY4 2.99777540204168 1.26370498493024e-78 0.363624047287499 0.0168187084939681 mirMAP -0.107769926345185 0.000264327137473322 NA NA NA hsa-miR-182-5p WDFY4 2.36408084103818 2.60011457600281e-72 0.363624047287499 0.0168187084939681 mirMAP -0.149543587249161 3.56398069270414e-05 NA NA NA hsa-miR-429 WDR17 2.84108892259147 3.88520896426515e-64 -1.83689863449786 1.91918439203299e-11 miRanda -0.251219660141955 1.53236009968371e-06 NA NA NA hsa-miR-452-5p WDR35 -2.48486455572568 1.24430987974325e-33 -0.383314507255633 4.60264874844637e-06 MirTarget -0.105150698402895 1.70887302861035e-15 NA NA NA hsa-miR-21-3p WDR37 2.17476065946878 5.15299442583591e-75 -0.313239163519098 9.67902626406522e-08 MirTarget -0.106306984359839 4.44246767435175e-12 NA NA NA hsa-miR-21-5p WDR7 2.32007501846389 3.08394781855554e-137 -0.389052890445945 5.42666951665451e-09 miRNAWalker2_validate -0.180698862319217 1.27006834936194e-18 NA NA NA hsa-miR-335-5p WFDC3 -2.61355235628987 2.6462884165886e-51 0.863467198832495 2.98283598168343e-06 miRNAWalker2_validate -0.151129211063764 1.12540166038692e-05 NA NA NA hsa-miR-335-5p WFIKKN1 -2.61355235628987 2.6462884165886e-51 1.21945982350394 8.27972234236372e-13 miRNAWalker2_validate -0.110057916896282 0.000600288179667408 NA NA NA hsa-miR-107 WIF1 0.678998026350662 2.56224148930538e-16 -5.2938799615046 1.46131868175141e-36 miRanda -0.805243011250718 6.66023850485786e-06 NA NA NA hsa-miR-320b WIF1 0.412787504747938 0.00113457276903985 -5.2938799615046 1.46131868175141e-36 miRanda -0.250626959028316 0.0356605312110271 NA NA NA hsa-miR-330-3p WIF1 0.432728362037032 0.00041335506960812 -5.2938799615046 1.46131868175141e-36 PITA;miRNATAP -0.303568377711378 0.0147013444545922 NA NA NA hsa-miR-330-5p WIF1 0.626063225953928 3.42215028606779e-09 -5.2938799615046 1.46131868175141e-36 miRanda -0.660990097984299 2.58056748637709e-06 NA NA NA hsa-miR-342-3p WIF1 1.21944481975657 6.81914373001202e-19 -5.2938799615046 1.46131868175141e-36 miRanda -0.900150959597263 1.15455195350394e-17 NA NA NA hsa-miR-429 WIF1 2.84108892259147 3.88520896426515e-64 -5.2938799615046 1.46131868175141e-36 miRanda -0.57801116079909 1.92906319858818e-12 NA NA NA hsa-miR-590-3p WIF1 1.27438512890514 1.03164723481469e-23 -5.2938799615046 1.46131868175141e-36 PITA;miRanda;mirMAP -0.639334008119333 9.64663705878253e-08 NA NA NA hsa-miR-141-3p WIPF1 2.99777540204168 1.26370498493024e-78 -0.259862115966063 0.00927399244683076 MirTarget;TargetScan;miRNATAP -0.182826846335189 4.90344827226961e-22 NA NA NA hsa-miR-182-5p WIPF1 2.36408084103818 2.60011457600281e-72 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.204600499940618 1.81098457609361e-18 NA NA NA hsa-miR-200a-3p WIPF1 2.55218480823434 2.96135446816238e-51 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.168234298344575 1.8780051849382e-19 NA NA NA hsa-miR-200b-3p WIPF1 2.11744072703209 1.66710572104191e-43 -0.259862115966063 0.00927399244683076 MirTarget;TargetScan -0.191286536551454 2.66416174733952e-20 NA NA NA hsa-miR-200c-3p WIPF1 2.07038651806183 6.84613386286599e-51 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.214983608550577 3.51466280882004e-21 NA NA NA hsa-miR-429 WIPF1 2.84108892259147 3.88520896426515e-64 -0.259862115966063 0.00927399244683076 MirTarget;PITA;miRanda;miRNATAP -0.149155676053519 1.12977711919918e-15 NA NA NA hsa-miR-96-5p WIPF1 3.24596558166606 1.92296159041707e-98 -0.259862115966063 0.00927399244683076 miRNATAP -0.17727693941722 4.4720669610493e-20 NA NA NA hsa-miR-375 WIPF3 2.09893673049766 1.68351780396203e-16 -0.995051311631194 1.88559735333109e-09 miRanda -0.142538214430048 6.68222215853349e-11 NA NA NA hsa-miR-335-5p WISP1 -2.61355235628987 2.6462884165886e-51 3.51580490215732 2.69373047170497e-80 miRNAWalker2_validate -0.391157938601224 3.63325504484974e-26 NA NA NA hsa-miR-429 WLS 2.84108892259147 3.88520896426515e-64 -1.69282853366533 3.60290250907942e-28 miRanda -0.29602731579252 6.11617215054703e-24 NA NA NA hsa-miR-21-5p WNK1 2.32007501846389 3.08394781855554e-137 -0.169704660612449 0.0326458451353318 miRNAWalker2_validate -0.126676800755744 2.62566085278265e-07 NA NA NA hsa-miR-200a-3p WNK3 2.55218480823434 2.96135446816238e-51 -1.22066858615062 3.01056061938594e-09 mirMAP -0.106464900309189 0.00723468109119119 NA NA NA hsa-miR-21-5p WNK3 2.32007501846389 3.08394781855554e-137 -1.22066858615062 3.01056061938594e-09 miRNAWalker2_validate -0.387261682088303 1.64774796083302e-09 NA NA NA hsa-miR-664a-3p WNT10A -0.237699857923843 0.0197071390183375 0.117967940665565 0.575368915720145 mirMAP -0.421214281367344 2.22889192706043e-09 NA NA NA hsa-miR-148a-3p WNT10B 0.706969798912638 5.52538085480485e-09 -1.41823796113152 2.7990884610486e-14 MirTarget -0.225697074269929 2.08337307308921e-05 NA NA NA hsa-miR-148b-3p WNT10B 1.0552576751879 1.6679285705231e-29 -1.41823796113152 2.7990884610486e-14 MirTarget -0.328579720045847 9.29413365918993e-07 NA NA NA hsa-miR-342-3p WNT10B 1.21944481975657 6.81914373001202e-19 -1.41823796113152 2.7990884610486e-14 miRanda -0.184377326541959 6.55689831892104e-05 NA NA NA hsa-miR-429 WNT11 2.84108892259147 3.88520896426515e-64 -2.30325701780235 1.00447815143943e-22 miRNATAP -0.283953214425953 3.59806376562941e-10 NA NA NA hsa-miR-590-3p WNT11 1.27438512890514 1.03164723481469e-23 -2.30325701780235 1.00447815143943e-22 miRanda -0.293944853552164 8.66172138800842e-06 NA NA NA hsa-miR-139-5p WNT2 -3.25846663863766 2.62018989415003e-112 0.997314912839432 9.86785362783619e-08 miRanda -0.250813000106968 6.69310140321002e-11 NA NA NA hsa-miR-335-3p WNT2 -1.88448538773649 2.09538234398335e-32 0.997314912839432 9.86785362783619e-08 mirMAP -0.124921231734074 0.0013759064532322 NA NA NA hsa-miR-361-3p WNT2 -0.0370446538644886 0.624902392829872 0.997314912839432 9.86785362783619e-08 MirTarget -0.266339316841169 0.00199408748413513 NA NA NA hsa-miR-130b-3p WNT2B 1.38122163823846 1.00932179737836e-26 -0.785015258390785 3.85219049480573e-09 MirTarget -0.16709837520953 1.43976112122382e-06 NA NA NA hsa-miR-301a-3p WNT2B 1.32170168375632 2.12280368957514e-15 -0.785015258390785 3.85219049480573e-09 MirTarget -0.104564831857354 0.000130211401798741 NA NA NA hsa-miR-429 WNT2B 2.84108892259147 3.88520896426515e-64 -0.785015258390785 3.85219049480573e-09 miRNATAP -0.137551404474967 5.5132158702989e-08 NA NA NA hsa-miR-454-3p WNT2B 1.28177672191095 6.84024979484587e-21 -0.785015258390785 3.85219049480573e-09 MirTarget -0.174716398885358 1.14167579103774e-07 NA NA NA hsa-miR-146a-5p WNT3 0.102405752365098 0.486975378688068 0.707252279816307 1.60330481675813e-05 MirTarget -0.201603839063412 1.26011961583069e-07 NA NA NA hsa-miR-146b-5p WNT3 0.631041661167954 6.20366593452965e-08 0.707252279816307 1.60330481675813e-05 MirTarget;PITA;miRanda;miRNATAP -0.19864051897856 3.55693736099291e-05 NA NA NA hsa-miR-214-3p WNT3 -0.523705501275844 0.000211299789901139 0.707252279816307 1.60330481675813e-05 MirTarget -0.217458243957451 4.77314673966333e-08 NA NA NA hsa-miR-215-5p WNT3 -1.35643065897947 2.3180023440257e-20 0.707252279816307 1.60330481675813e-05 miRNAWalker2_validate -0.202617944190342 6.29886106348422e-08 NA NA NA hsa-miR-374a-3p WNT3 0.34122393953022 2.28714105382856e-05 0.707252279816307 1.60330481675813e-05 MirTarget -0.289753487107474 3.61014430173007e-05 NA NA NA hsa-miR-374a-5p WNT3 -0.239709888246804 0.00309819667153627 0.707252279816307 1.60330481675813e-05 MirTarget -0.450647176110379 8.40472532505734e-11 NA NA NA hsa-miR-374b-5p WNT3 -0.466781429946153 1.17238311619116e-08 0.707252279816307 1.60330481675813e-05 MirTarget -0.339662315482385 7.32586953128491e-07 NA NA NA hsa-miR-376c-3p WNT3 -1.23221625820254 6.08631316990405e-17 0.707252279816307 1.60330481675813e-05 MirTarget -0.209776014145028 2.6988219390376e-08 NA NA NA hsa-miR-576-5p WNT3 0.0649387707567879 0.588791966096287 0.707252279816307 1.60330481675813e-05 mirMAP -0.138865149881875 0.0032152515286964 NA NA NA hsa-miR-589-3p WNT3 0.0263457630961427 0.866577983997705 0.707252279816307 1.60330481675813e-05 mirMAP -0.105204288945704 0.00433518385741643 NA NA NA hsa-miR-16-5p WNT3A 0.46835991343556 1.91125356547776e-06 0.138281478831945 0.560611727974706 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.223562434556754 0.00686252591255575 NA NA NA hsa-miR-331-3p WNT3A 0.74441480542886 1.17071235477799e-07 0.138281478831945 0.560611727974706 mirMAP -0.186748490696253 0.00116808678187749 NA NA NA hsa-miR-335-5p WNT3A -2.61355235628987 2.6462884165886e-51 0.138281478831945 0.560611727974706 mirMAP -0.144104496367168 0.00107984254818266 NA NA NA hsa-let-7a-3p WNT5A 0.466622567891891 3.70886257943079e-07 -0.0987969676790623 0.559050375624812 miRNATAP -0.22117753231769 0.000441970481202632 NA NA NA hsa-miR-126-5p WNT5A -1.27745588751177 2.96000918537631e-30 -0.0987969676790623 0.559050375624812 mirMAP -0.121538798785954 0.015283230436261 NA NA NA hsa-miR-140-3p WNT5A -1.25844395244141 5.29222651039892e-33 -0.0987969676790623 0.559050375624812 MirTarget;miRNATAP -0.114362373598219 0.0313125845610264 NA NA NA hsa-miR-141-3p WNT5A 2.99777540204168 1.26370498493024e-78 -0.0987969676790623 0.559050375624812 TargetScan -0.139214845204003 2.12785375749739e-05 NA NA NA hsa-miR-144-5p WNT5A -2.75914786146772 1.55794225315972e-50 -0.0987969676790623 0.559050375624812 mirMAP -0.108189974261664 0.000232182868580216 NA NA NA hsa-miR-155-5p WNT5A 1.09766314984151 4.55650930885814e-15 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate;mirMAP -0.104443534618959 0.0103110503358659 NA NA NA hsa-miR-15b-3p WNT5A 1.12898579025388 1.18050912917317e-14 -0.0987969676790623 0.559050375624812 mirMAP -0.282465371884018 2.03011972026487e-13 NA NA NA hsa-miR-16-2-3p WNT5A 0.286355254959005 0.0256946046884474 -0.0987969676790623 0.559050375624812 MirTarget;mirMAP -0.339885804294178 3.30301649240528e-14 NA NA NA hsa-miR-16-5p WNT5A 0.46835991343556 1.91125356547776e-06 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate -0.443371863255678 2.01154967356747e-14 NA NA NA hsa-miR-186-5p WNT5A -0.426987301460247 1.04129380549315e-05 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate;mirMAP;miRNATAP -0.302944959464288 3.52342706593741e-07 NA NA NA hsa-miR-26b-5p WNT5A -0.331527896896866 0.000551258576575092 -0.0987969676790623 0.559050375624812 mirMAP;miRNATAP -0.128410741477027 0.0339630309215917 NA NA NA hsa-miR-29a-5p WNT5A 0.334183773952055 0.00445137265870197 -0.0987969676790623 0.559050375624812 mirMAP -0.173390051712273 0.000449511750498096 NA NA NA hsa-miR-30b-5p WNT5A -0.46540603860146 2.4709940429591e-05 -0.0987969676790623 0.559050375624812 mirMAP -0.221268990849156 2.30222342732902e-05 NA NA NA hsa-miR-30c-5p WNT5A -0.393222674580066 8.06961465717306e-05 -0.0987969676790623 0.559050375624812 mirMAP -0.153444255475845 0.00829557687465555 NA NA NA hsa-miR-30d-3p WNT5A 0.264544633563642 0.00755023189129747 -0.0987969676790623 0.559050375624812 mirMAP -0.328486161205366 1.77036516167105e-08 NA NA NA hsa-miR-30d-5p WNT5A -0.247082219011045 0.00406717930063148 -0.0987969676790623 0.559050375624812 mirMAP -0.395918928140374 3.76530346593888e-09 NA NA NA hsa-miR-30e-5p WNT5A 0.293491764699475 0.000372291967271834 -0.0987969676790623 0.559050375624812 mirMAP -0.355937424695316 3.98104999357833e-07 NA NA NA hsa-miR-330-5p WNT5A 0.626063225953928 3.42215028606779e-09 -0.0987969676790623 0.559050375624812 miRanda -0.254694138871707 2.53849290717674e-06 NA NA NA hsa-miR-340-5p WNT5A 1.0857159627596 4.94471062546756e-24 -0.0987969676790623 0.559050375624812 miRNATAP -0.151352324882194 0.00401003633166406 NA NA NA hsa-miR-374b-5p WNT5A -0.466781429946153 1.17238311619116e-08 -0.0987969676790623 0.559050375624812 MirTarget;miRNATAP -0.20398183143879 0.00391173355873326 NA NA NA hsa-miR-576-5p WNT5A 0.0649387707567879 0.588791966096287 -0.0987969676790623 0.559050375624812 mirMAP -0.219900857430154 5.01514505641987e-06 NA NA NA hsa-miR-590-3p WNT5A 1.27438512890514 1.03164723481469e-23 -0.0987969676790623 0.559050375624812 miRanda;mirMAP;miRNATAP -0.276206250056969 2.00878373474974e-09 NA NA NA hsa-miR-7-1-3p WNT5A 0.686579567507582 1.20731554448806e-07 -0.0987969676790623 0.559050375624812 mirMAP -0.228321533184529 2.31205663077237e-07 NA NA NA hsa-miR-92a-3p WNT5A -0.342420481092807 0.000732275969501111 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate -0.456191278985706 5.11502285589708e-16 NA NA NA hsa-miR-339-5p WNT5B -0.211548290465418 0.0685885445822389 -0.676281807762083 1.11957729947182e-05 miRanda -0.185095344713092 5.01294231609421e-05 NA NA NA hsa-miR-10b-5p WNT7B -2.10996264627796 7.36811595736367e-72 2.29617242327329 2.05565381147612e-26 mirMAP -0.19739104901179 0.00088619253374349 NA NA NA hsa-miR-30a-5p WNT7B -0.392489994825279 0.00954894667761676 2.29617242327329 2.05565381147612e-26 miRNATAP -0.244710473588963 1.09537488646518e-06 NA NA NA hsa-miR-30b-3p WNT7B -0.536462824497982 2.41814659272548e-05 2.29617242327329 2.05565381147612e-26 MirTarget;mirMAP -0.199927265231065 0.000916083804937799 NA NA NA hsa-miR-30c-5p WNT7B -0.393222674580066 8.06961465717306e-05 2.29617242327329 2.05565381147612e-26 miRNATAP -0.455544291260138 2.11209121770824e-09 NA NA NA hsa-miR-326 WNT7B -1.54449030848141 1.04703417845594e-17 2.29617242327329 2.05565381147612e-26 MirTarget;miRanda -0.161789035877396 9.64577721935033e-05 NA NA NA hsa-miR-335-5p WNT7B -2.61355235628987 2.6462884165886e-51 2.29617242327329 2.05565381147612e-26 miRNAWalker2_validate -0.23895557225465 6.17708068119425e-09 NA NA NA hsa-miR-491-5p WNT7B -1.04307210952796 1.14586501470398e-15 2.29617242327329 2.05565381147612e-26 mirMAP -0.270664526249752 2.96434624276917e-06 NA NA NA hsa-miR-505-3p WNT7B -0.530462599544864 7.71645736541597e-05 2.29617242327329 2.05565381147612e-26 miRNATAP -0.25367826265264 7.46180280225906e-06 NA NA NA hsa-let-7a-3p WNT9A 0.466622567891891 3.70886257943079e-07 0.447765230183606 0.0124427267373267 mirMAP -0.134171267872056 0.0451424441710751 NA NA NA hsa-miR-1271-5p WNT9A -1.08290983583835 3.85149976357318e-12 0.447765230183606 0.0124427267373267 mirMAP -0.151077426632908 0.000116310190119482 NA NA NA hsa-miR-148a-3p WNT9A 0.706969798912638 5.52538085480485e-09 0.447765230183606 0.0124427267373267 mirMAP -0.298084226700717 2.38424942045375e-09 NA NA NA hsa-miR-148b-3p WNT9A 1.0552576751879 1.6679285705231e-29 0.447765230183606 0.0124427267373267 mirMAP -0.216690484061052 0.000659770444792974 NA NA NA hsa-miR-15b-5p WNT9A 0.788659356634696 1.13678211092534e-11 0.447765230183606 0.0124427267373267 mirMAP -0.160780744423949 0.00213391068310254 NA NA NA hsa-miR-16-5p WNT9A 0.46835991343556 1.91125356547776e-06 0.447765230183606 0.0124427267373267 mirMAP -0.294351524109689 2.19404233093207e-06 NA NA NA hsa-miR-181a-2-3p WNT9A -0.0718643470098321 0.422077954889554 0.447765230183606 0.0124427267373267 mirMAP -0.200099377422022 0.00380063581033883 NA NA NA hsa-miR-193a-3p WNT9A 0.310617999804917 0.00477640270974957 0.447765230183606 0.0124427267373267 mirMAP -0.305391600401298 3.90157370096497e-08 NA NA NA hsa-miR-195-5p WNT9A -1.47508108420708 2.20685847368258e-38 0.447765230183606 0.0124427267373267 mirMAP -0.196363300820022 0.000137496059895827 NA NA NA hsa-miR-28-5p WNT9A -0.14267073663385 0.0497619246260571 0.447765230183606 0.0124427267373267 mirMAP -0.292797790744078 0.000600350405048975 NA NA NA hsa-miR-32-5p WNT9A 1.38676603945192 2.29428299685976e-34 0.447765230183606 0.0124427267373267 mirMAP -0.216445530743276 3.06978747423399e-05 NA NA NA hsa-miR-331-3p WNT9A 0.74441480542886 1.17071235477799e-07 0.447765230183606 0.0124427267373267 mirMAP -0.137832471681534 0.00151040501960236 NA NA NA hsa-miR-335-5p WNT9A -2.61355235628987 2.6462884165886e-51 0.447765230183606 0.0124427267373267 miRNAWalker2_validate -0.146714794864289 9.92998698360538e-06 NA NA NA hsa-miR-363-3p WNT9A -0.0402062060863897 0.833024617256265 0.447765230183606 0.0124427267373267 mirMAP -0.126772985407334 8.48022074883423e-05 NA NA NA hsa-miR-424-5p WNT9A 0.420789584199235 0.00480101660479489 0.447765230183606 0.0124427267373267 mirMAP -0.203387678407749 6.84865574984046e-07 NA NA NA hsa-miR-497-5p WNT9A -1.4667331575679 5.49909921822638e-36 0.447765230183606 0.0124427267373267 mirMAP -0.228181412286226 5.31377710156938e-06 NA NA NA hsa-miR-532-3p WNT9A -0.395473145042459 0.00686714288452761 0.447765230183606 0.0124427267373267 mirMAP -0.144881932218838 0.000552241596034881 NA NA NA hsa-miR-708-5p WNT9A 0.638386255192461 1.19735143565146e-06 0.447765230183606 0.0124427267373267 mirMAP -0.12045189873946 0.00968711444884768 NA NA NA hsa-miR-139-5p WRNIP1 -3.25846663863766 2.62018989415003e-112 0.625065490911775 3.10746321499976e-26 miRanda -0.142608572256843 2.10548479916237e-32 NA NA NA hsa-miR-141-3p WTIP 2.99777540204168 1.26370498493024e-78 -0.673697271502645 8.0399213972999e-08 mirMAP -0.225708945128347 5.44689065635373e-21 NA NA NA hsa-miR-183-5p WTIP 2.95681814393872 1.09965777344285e-92 -0.673697271502645 8.0399213972999e-08 mirMAP -0.233303798414219 3.87335814437078e-19 NA NA NA hsa-miR-200a-3p WTIP 2.55218480823434 2.96135446816238e-51 -0.673697271502645 8.0399213972999e-08 mirMAP -0.153578019023446 1.2728190646307e-10 NA NA NA hsa-miR-141-3p WWC2 2.99777540204168 1.26370498493024e-78 -0.909757247991017 3.54549072341367e-12 mirMAP -0.227020947819862 2.22048189774092e-19 NA NA NA hsa-miR-182-5p WWC2 2.36408084103818 2.60011457600281e-72 -0.909757247991017 3.54549072341367e-12 MirTarget -0.121276057482618 0.000119343429038959 NA NA NA hsa-miR-200a-3p WWC2 2.55218480823434 2.96135446816238e-51 -0.909757247991017 3.54549072341367e-12 mirMAP -0.196388107244229 2.92794464455906e-15 NA NA NA hsa-miR-21-5p WWC2 2.32007501846389 3.08394781855554e-137 -0.909757247991017 3.54549072341367e-12 miRNAWalker2_validate -0.198974767729545 1.3114686290144e-06 NA NA NA hsa-miR-429 WWC2 2.84108892259147 3.88520896426515e-64 -0.909757247991017 3.54549072341367e-12 miRanda;miRNATAP -0.194673204523923 3.32299470755331e-15 NA NA NA hsa-miR-141-3p WWTR1 2.99777540204168 1.26370498493024e-78 -0.946157092633412 9.0126903364314e-15 MirTarget;TargetScan;miRNATAP -0.183547997043091 1.1010774322509e-14 NA NA NA hsa-miR-200a-3p WWTR1 2.55218480823434 2.96135446816238e-51 -0.946157092633412 9.0126903364314e-15 MirTarget;miRNATAP -0.182565021897447 4.59067387987806e-15 NA NA NA hsa-miR-200b-3p XG 2.11744072703209 1.66710572104191e-43 -1.55383315404176 7.05287200308045e-18 MirTarget -0.355395373239176 1.30097802792361e-20 NA NA NA hsa-miR-200c-3p XG 2.07038651806183 6.84613386286599e-51 -1.55383315404176 7.05287200308045e-18 MirTarget -0.42057390275489 8.34040723588348e-24 NA NA NA hsa-miR-429 XG 2.84108892259147 3.88520896426515e-64 -1.55383315404176 7.05287200308045e-18 MirTarget;miRanda -0.318686006845656 8.83414272837737e-21 NA NA NA hsa-miR-139-5p XIRP1 -3.25846663863766 2.62018989415003e-112 2.19891384053617 1.07774521981711e-17 miRanda -0.409039677112826 1.41477181712819e-14 NA NA NA hsa-miR-335-5p XIRP1 -2.61355235628987 2.6462884165886e-51 2.19891384053617 1.07774521981711e-17 miRNAWalker2_validate -0.311747621525831 1.00795476629158e-10 NA NA NA hsa-miR-210-3p XIST 2.38367203491819 3.73261999106754e-22 -1.16469794619773 8.95349913827841e-07 miRTarBase -0.164142594925795 3.22084256847945e-07 NA NA NA hsa-miR-139-5p XKRX -3.25846663863766 2.62018989415003e-112 1.31316296433694 3.71037037004171e-20 miRanda -0.275921042129998 6.37859141233537e-21 NA NA NA hsa-miR-335-5p XKRX -2.61355235628987 2.6462884165886e-51 1.31316296433694 3.71037037004171e-20 miRNAWalker2_validate -0.140860863351896 1.84171449312339e-07 NA NA NA hsa-miR-21-5p XPO4 2.32007501846389 3.08394781855554e-137 -0.380056801369188 1.48808995244813e-07 mirMAP -0.16262087766467 3.67257985410033e-13 NA NA NA hsa-miR-10b-5p XRCC3 -2.10996264627796 7.36811595736367e-72 0.734264365065646 9.3532318956229e-17 mirMAP -0.259539097842263 4.00310926260914e-29 NA NA NA hsa-miR-141-5p XYLT1 2.38411349683216 4.56310582620282e-58 -0.871966257661826 2.6739267034943e-11 mirMAP -0.18945060027909 1.64474851219039e-11 NA NA NA hsa-miR-429 XYLT1 2.84108892259147 3.88520896426515e-64 -0.871966257661826 2.6739267034943e-11 miRNATAP -0.201211521553782 3.32998990217326e-16 NA NA NA hsa-miR-141-3p YAP1 2.99777540204168 1.26370498493024e-78 -1.31738265371239 9.58372053397518e-43 MirTarget;TargetScan -0.224844503629252 1.84225185456191e-32 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-141-5p YAP1 2.38411349683216 4.56310582620282e-58 -1.31738265371239 9.58372053397518e-43 miRNATAP -0.208516538810642 8.25160642292028e-23 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-200a-3p YAP1 2.55218480823434 2.96135446816238e-51 -1.31738265371239 9.58372053397518e-43 miRNAWalker2_validate;MirTarget -0.179180498954883 2.18192480130206e-21 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 2.11744072703209 1.66710572104191e-43 -1.31738265371239 9.58372053397518e-43 MirTarget -0.192196263932001 6.22401511406624e-20 NA NA NA hsa-miR-200c-3p YAP1 2.07038651806183 6.84613386286599e-51 -1.31738265371239 9.58372053397518e-43 MirTarget -0.246914816784172 4.26453849203752e-27 NA NA NA hsa-miR-21-5p YAP1 2.32007501846389 3.08394781855554e-137 -1.31738265371239 9.58372053397518e-43 MirTarget;miRNATAP -0.325756536921103 2.08121491758625e-26 NA NA NA hsa-miR-375 YAP1 2.09893673049766 1.68351780396203e-16 -1.31738265371239 9.58372053397518e-43 miRNAWalker2_validate;miRTarBase;miRNATAP -0.120107822997014 3.96634849887855e-20 27270433;23685355;20226166;21856745 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer; Knockdown of YAP1 phenocopied miR-375 overexpression and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375;Overexpression of miR 10a and miR 375 and downregulation of YAP1 in medullary thyroid carcinoma; Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes; Furthermore the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375;MicroRNA 375 targets Hippo signaling effector YAP in liver cancer and inhibits tumor properties; The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA miRNA miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients n=48; As determined by luciferase reporter assay we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP; Furthermore immunoblotting revealed miR-375 suppressed endogenous YAP protein level; miR-375 is an important regulator of YAP oncogene implicating a potential therapeutic role in HCC treatment;miR 375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer; The transcriptional coactivator YAP1 was determined to be a direct target of miR-375; YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells ;;; prostate cancer;thyroid cancer;liver cancer;lung cancer hsa-miR-429 YAP1 2.84108892259147 3.88520896426515e-64 -1.31738265371239 9.58372053397518e-43 MirTarget;miRanda -0.173689900979646 2.12181225777702e-20 NA NA NA hsa-miR-375 YBX1 2.09893673049766 1.68351780396203e-16 -0.123236840794476 0.149132087520584 miRanda;miRNATAP -0.12967207547794 4.02018460903968e-33 27466996 MiR 375 is epigenetically downregulated due to promoter methylation and modulates multi drug resistance in breast cancer cells via targeting YBX1; In this study we firstly verified how miR-375 is downregulated in breast cancer cells with multi-drug resistance MDR and further investigated the regulative effect of miR-375 on Ybx1 expression; The binding between miR-375 and YBX1 gene was predicted using Targetscan 7.1 and verified using western blot and dual luciferase assay; MiR-375 can directly target 3'UTR of YBX1 and thereby decrease its expression in MCF-7/ADM and MCF-7/PTX cells; Both miR-375 overexpression and YBX1 knockdown significantly decreased P-gp expression and increased chemosensitivity of the cancer cells; MiR-375 can directly target 3'UTR of YBX1 and thereby decrease its expression which might be an important mechanism of MDR in breast cancer cells drug resistance breast cancer hsa-miR-200b-3p YPEL2 2.11744072703209 1.66710572104191e-43 -0.531843694095341 3.20174565714011e-08 TargetScan -0.112985153524515 3.12055418281865e-08 NA NA NA hsa-miR-200c-3p YPEL2 2.07038651806183 6.84613386286599e-51 -0.531843694095341 3.20174565714011e-08 miRNATAP -0.147767221733321 3.90405614738872e-11 NA NA NA hsa-miR-21-5p YPEL2 2.32007501846389 3.08394781855554e-137 -0.531843694095341 3.20174565714011e-08 mirMAP -0.191453030914219 1.53802406846675e-10 NA NA NA hsa-miR-429 YPEL2 2.84108892259147 3.88520896426515e-64 -0.531843694095341 3.20174565714011e-08 PITA;miRanda;miRNATAP -0.129965506518504 7.33287963026229e-13 NA NA NA hsa-miR-139-5p YTHDF1 -3.25846663863766 2.62018989415003e-112 0.562340410960841 2.94451260080466e-28 miRanda -0.116383985207253 1.10880840702798e-28 NA NA NA hsa-miR-200b-3p YWHAG 2.11744072703209 1.66710572104191e-43 -0.30496627096666 3.16855379814272e-06 MirTarget;TargetScan -0.11952750278469 2.04909339347489e-18 NA NA NA hsa-miR-200c-3p YWHAG 2.07038651806183 6.84613386286599e-51 -0.30496627096666 3.16855379814272e-06 MirTarget;miRNATAP -0.115098762293347 2.44122702999837e-14 NA NA NA hsa-miR-21-5p ZADH2 2.32007501846389 3.08394781855554e-137 -0.367424027171902 2.87936046802471e-07 miRNAWalker2_validate;mirMAP -0.236140452123295 1.61465154504701e-27 NA NA NA hsa-miR-335-5p ZBED2 -2.61355235628987 2.6462884165886e-51 1.74191041977964 5.64980884398407e-12 miRNAWalker2_validate -0.237159800408 5.53745975030105e-07 NA NA NA hsa-miR-141-3p ZBED3 2.99777540204168 1.26370498493024e-78 -1.03544978166773 5.82584960514108e-21 mirMAP -0.171544846006012 2.03628726726465e-15 NA NA NA hsa-miR-200a-3p ZBED3 2.55218480823434 2.96135446816238e-51 -1.03544978166773 5.82584960514108e-21 mirMAP -0.163383673828219 1.3753615171095e-14 NA NA NA hsa-miR-139-5p ZBED4 -3.25846663863766 2.62018989415003e-112 0.510499432695762 7.42146069255746e-13 miRanda -0.139763579815229 4.62136592699504e-22 NA NA NA hsa-miR-200a-3p ZBTB10 2.55218480823434 2.96135446816238e-51 -0.611029416368402 8.44024410685276e-06 mirMAP -0.134738385366774 2.56320263015494e-07 NA NA NA hsa-miR-200b-3p ZBTB10 2.11744072703209 1.66710572104191e-43 -0.611029416368402 8.44024410685276e-06 MirTarget -0.124716276670106 1.88539267361412e-05 NA NA NA hsa-miR-429 ZBTB10 2.84108892259147 3.88520896426515e-64 -0.611029416368402 8.44024410685276e-06 MirTarget;miRanda;miRNATAP -0.111775650519019 1.75581336839058e-05 NA NA NA hsa-miR-141-3p ZBTB16 2.99777540204168 1.26370498493024e-78 -4.63985301217587 2.47816545143769e-48 TargetScan -0.858851285229463 2.62803662236148e-43 NA NA NA hsa-miR-200b-3p ZBTB16 2.11744072703209 1.66710572104191e-43 -4.63985301217587 2.47816545143769e-48 TargetScan -0.662341942072399 2.71948254848324e-21 NA NA NA hsa-miR-141-3p ZBTB20 2.99777540204168 1.26370498493024e-78 -1.72085519412909 2.5148540758039e-32 MirTarget;TargetScan -0.289077227294819 5.29009513839861e-24 NA NA NA hsa-miR-200a-3p ZBTB20 2.55218480823434 2.96135446816238e-51 -1.72085519412909 2.5148540758039e-32 MirTarget -0.241363570116639 1.51792306924559e-17 NA NA NA hsa-miR-200b-3p ZBTB20 2.11744072703209 1.66710572104191e-43 -1.72085519412909 2.5148540758039e-32 TargetScan -0.244254584375419 1.092445337669e-14 NA NA NA hsa-miR-21-5p ZBTB20 2.32007501846389 3.08394781855554e-137 -1.72085519412909 2.5148540758039e-32 miRNAWalker2_validate -0.512160134920868 2.50160661161994e-29 NA NA NA hsa-miR-96-5p ZBTB20 3.24596558166606 1.92296159041707e-98 -1.72085519412909 2.5148540758039e-32 TargetScan -0.316443301493847 8.32772323226157e-28 NA NA NA hsa-miR-335-5p ZBTB32 -2.61355235628987 2.6462884165886e-51 1.18838647883975 2.36756498071984e-13 miRNAWalker2_validate -0.167043972908233 3.85668809675164e-08 NA NA NA hsa-miR-200b-3p ZBTB38 2.11744072703209 1.66710572104191e-43 -0.896891924711862 1.92458588029593e-26 TargetScan -0.122629940797949 1.7968915362846e-11 NA NA NA hsa-miR-21-5p ZBTB38 2.32007501846389 3.08394781855554e-137 -0.896891924711862 1.92458588029593e-26 miRNAWalker2_validate -0.292897687469219 4.97513187822961e-29 NA NA NA hsa-miR-429 ZBTB38 2.84108892259147 3.88520896426515e-64 -0.896891924711862 1.92458588029593e-26 PITA;miRanda -0.138832479241027 8.42862776901346e-18 NA NA NA hsa-miR-429 ZBTB4 2.84108892259147 3.88520896426515e-64 -0.898210741493696 2.5617186204132e-41 miRNATAP -0.129886703411911 9.38412500342728e-24 NA NA NA hsa-miR-21-5p ZBTB47 2.32007501846389 3.08394781855554e-137 -0.773093000610286 2.43222968030568e-25 miRNAWalker2_validate -0.168184830331374 9.33581199668469e-13 NA NA NA hsa-miR-96-5p ZBTB47 3.24596558166606 1.92296159041707e-98 -0.773093000610286 2.43222968030568e-25 mirMAP -0.159797057556593 1.04800332947165e-27 NA NA NA hsa-miR-335-5p ZBTB7B -2.61355235628987 2.6462884165886e-51 0.715693870145667 7.68515690735954e-18 miRNAWalker2_validate -0.112596511270438 4.55288303042053e-13 NA NA NA hsa-miR-200b-3p ZC3H12B 2.11744072703209 1.66710572104191e-43 -1.71800694666271 1.87602247508669e-49 mirMAP -0.240916484226689 5.1761566883771e-21 NA NA NA hsa-miR-200c-3p ZC3H12B 2.07038651806183 6.84613386286599e-51 -1.71800694666271 1.87602247508669e-49 mirMAP -0.261786630015696 1.56794712673725e-20 NA NA NA hsa-miR-429 ZC3H12B 2.84108892259147 3.88520896426515e-64 -1.71800694666271 1.87602247508669e-49 PITA;mirMAP -0.256195649932829 9.19358246721795e-30 NA NA NA hsa-miR-141-3p ZC3H12C 2.99777540204168 1.26370498493024e-78 -1.86703657263613 2.43378212227188e-45 MirTarget -0.282180972071193 9.13175461753934e-27 NA NA NA hsa-miR-182-5p ZC3H12C 2.36408084103818 2.60011457600281e-72 -1.86703657263613 2.43378212227188e-45 MirTarget -0.410991550265276 3.57097230231445e-38 NA NA NA hsa-miR-200a-3p ZC3H12C 2.55218480823434 2.96135446816238e-51 -1.86703657263613 2.43378212227188e-45 MirTarget -0.250416624606868 6.22098001861092e-22 NA NA NA hsa-miR-200a-5p ZC3H12C 2.58844508672328 1.79650654234569e-56 -1.86703657263613 2.43378212227188e-45 MirTarget;miRNATAP -0.238070334838196 5.50570767232636e-19 NA NA NA hsa-miR-200b-3p ZC3H12C 2.11744072703209 1.66710572104191e-43 -1.86703657263613 2.43378212227188e-45 TargetScan -0.283620764916226 9.95006759158569e-23 NA NA NA hsa-miR-200c-3p ZC3H12C 2.07038651806183 6.84613386286599e-51 -1.86703657263613 2.43378212227188e-45 miRNATAP -0.313872433644132 5.14238456112056e-23 NA NA NA hsa-miR-21-3p ZC3H12C 2.17476065946878 5.15299442583591e-75 -1.86703657263613 2.43378212227188e-45 MirTarget -0.191683950891034 1.63144010893901e-07 NA NA NA hsa-miR-429 ZC3H12C 2.84108892259147 3.88520896426515e-64 -1.86703657263613 2.43378212227188e-45 miRNATAP -0.24905154717158 5.42924215908374e-22 NA NA NA hsa-miR-96-5p ZC3H12C 3.24596558166606 1.92296159041707e-98 -1.86703657263613 2.43378212227188e-45 TargetScan -0.340382865547396 5.03274022315254e-38 NA NA NA hsa-miR-10b-5p ZC3H18 -2.10996264627796 7.36811595736367e-72 0.219991585208681 0.000571505054114802 miRNAWalker2_validate -0.17999497753484 9.16098691441862e-28 NA NA NA hsa-miR-145-5p ZC3H3 -2.62703571936687 7.64402900188551e-88 1.00966545791486 6.06487089619898e-39 MirTarget -0.247741544891831 9.23230639398146e-44 NA NA NA hsa-miR-141-3p ZC3H6 2.99777540204168 1.26370498493024e-78 -0.90118202780819 2.98269815664226e-29 mirMAP -0.114199857389598 8.06442824583304e-13 NA NA NA hsa-miR-200c-3p ZC3H6 2.07038651806183 6.84613386286599e-51 -0.90118202780819 2.98269815664226e-29 MirTarget;miRNATAP -0.111431462921858 6.9471410147556e-09 NA NA NA hsa-miR-429 ZC3H6 2.84108892259147 3.88520896426515e-64 -0.90118202780819 2.98269815664226e-29 MirTarget;PITA;miRanda;miRNATAP -0.104621764350867 1.82042015525915e-11 NA NA NA hsa-miR-429 ZC4H2 2.84108892259147 3.88520896426515e-64 -0.942409271091603 1.06114938304041e-11 miRanda -0.119609596339673 6.34066666327461e-06 NA NA NA hsa-miR-429 ZCCHC11 2.84108892259147 3.88520896426515e-64 -1.06355464707862 2.05848432401578e-17 miRanda -0.144800441230388 1.61681318451883e-09 NA NA NA hsa-miR-96-5p ZCCHC11 3.24596558166606 1.92296159041707e-98 -1.06355464707862 2.05848432401578e-17 TargetScan -0.204823340903985 1.57334855688199e-16 NA NA NA hsa-miR-141-3p ZCCHC24 2.99777540204168 1.26370498493024e-78 -1.58022302811898 5.17246192367e-42 MirTarget;TargetScan;miRNATAP -0.436172356007355 3.12974751241543e-94 NA NA NA hsa-miR-200a-3p ZCCHC24 2.55218480823434 2.96135446816238e-51 -1.58022302811898 5.17246192367e-42 MirTarget;miRNATAP -0.347079779358163 3.57314427974497e-57 NA NA NA hsa-miR-200b-3p ZCCHC24 2.11744072703209 1.66710572104191e-43 -1.58022302811898 5.17246192367e-42 MirTarget;TargetScan -0.357208016330032 4.11174945271936e-48 NA NA NA hsa-miR-200c-3p ZCCHC24 2.07038651806183 6.84613386286599e-51 -1.58022302811898 5.17246192367e-42 MirTarget;miRNATAP -0.467865610861613 1.37250115673723e-71 NA NA NA hsa-miR-429 ZCCHC24 2.84108892259147 3.88520896426515e-64 -1.58022302811898 5.17246192367e-42 MirTarget;miRanda;miRNATAP -0.347391216299411 3.49315660695196e-58 NA NA NA hsa-miR-429 ZDBF2 2.84108892259147 3.88520896426515e-64 -1.8979314282396 3.38671269808546e-29 PITA;miRanda -0.313015583865123 4.41364776479361e-22 NA NA NA hsa-miR-511-5p ZDHHC12 -2.27545475897362 3.84085514050558e-36 1.23782039592962 1.07214664940674e-44 MirTarget -0.138650010796645 9.26338822836329e-17 NA NA NA hsa-miR-182-5p ZDHHC14 2.36408084103818 2.60011457600281e-72 -0.389248814782605 4.64396996435094e-05 mirMAP -0.101809308714509 7.75460907081163e-06 NA NA NA hsa-miR-141-3p ZDHHC15 2.99777540204168 1.26370498493024e-78 -1.79355508284452 1.31588141500882e-28 MirTarget -0.249774889627413 6.41631415358165e-15 NA NA NA hsa-miR-183-5p ZDHHC15 2.95681814393872 1.09965777344285e-92 -1.79355508284452 1.31588141500882e-28 miRNATAP -0.303065953956547 1.85542128413411e-18 NA NA NA hsa-miR-200a-3p ZDHHC15 2.55218480823434 2.96135446816238e-51 -1.79355508284452 1.31588141500882e-28 MirTarget -0.165458951873093 1.87004378841089e-07 NA NA NA hsa-miR-200b-3p ZDHHC15 2.11744072703209 1.66710572104191e-43 -1.79355508284452 1.31588141500882e-28 MirTarget -0.16405872791292 3.5084105128664e-06 NA NA NA hsa-miR-200c-3p ZDHHC15 2.07038651806183 6.84613386286599e-51 -1.79355508284452 1.31588141500882e-28 MirTarget -0.236251197111668 1.04347195201818e-09 NA NA NA hsa-miR-429 ZDHHC15 2.84108892259147 3.88520896426515e-64 -1.79355508284452 1.31588141500882e-28 MirTarget;miRanda -0.214111271089349 8.51548430341575e-12 NA NA NA hsa-miR-200b-3p ZDHHC17 2.11744072703209 1.66710572104191e-43 -0.866022836216911 6.86139577858733e-36 MirTarget;TargetScan -0.107261278905147 1.41104537315877e-12 NA NA NA hsa-miR-200c-3p ZDHHC17 2.07038651806183 6.84613386286599e-51 -0.866022836216911 6.86139577858733e-36 MirTarget;miRNATAP -0.119261676412732 7.82406651936371e-13 NA NA NA hsa-miR-21-5p ZDHHC17 2.32007501846389 3.08394781855554e-137 -0.866022836216911 6.86139577858733e-36 miRNATAP -0.288627519195431 2.26497977409304e-41 NA NA NA hsa-miR-429 ZDHHC17 2.84108892259147 3.88520896426515e-64 -0.866022836216911 6.86139577858733e-36 MirTarget;PITA;miRanda;miRNATAP -0.121952391398073 8.63002404589141e-20 NA NA NA hsa-miR-96-5p ZDHHC17 3.24596558166606 1.92296159041707e-98 -0.866022836216911 6.86139577858733e-36 MirTarget;TargetScan;miRNATAP -0.110582119199941 3.81421255471712e-15 NA NA NA hsa-miR-182-5p ZDHHC8 2.36408084103818 2.60011457600281e-72 -0.267015726051314 0.00285683394442492 mirMAP -0.111801750499608 1.38320377902246e-07 NA NA NA hsa-miR-141-3p ZEB1 2.99777540204168 1.26370498493024e-78 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.372196262043322 7.31339268489263e-60 24424572;24307282;26783187 Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;drug resistance head and neck cancer;sarcoma;lung squamous cell cancer hsa-miR-183-5p ZEB1 2.95681814393872 1.09965777344285e-92 -1.20177694006781 1.58231961737395e-22 MirTarget;miRNATAP -0.260380892235961 9.69597046307861e-24 NA NA NA hsa-miR-200a-3p ZEB1 2.55218480823434 2.96135446816238e-51 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.319622679415122 1.50005867526347e-44 27402080;23626803;24037528;27402864;23743934;24815002;24424572;20473948;19854497;26887977;24390222;26242262;19544444 Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;;metastasis;;;;tumorigenesis;;;;;metastasis; breast cancer;breast cancer;breast cancer;sarcoma;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;colorectal cancer;prostate cancer hsa-miR-200b-3p ZEB1 2.11744072703209 1.66710572104191e-43 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.340144365122761 1.59273196940771e-40 27402080;26011542;23626803;24037528;24352645;27402864;23743934;24815002;24424572;20473948;19854497;26887977;24390222;27307751;26242262;19544444;26783187 Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways;Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;;metastasis;cell migration;;;;tumorigenesis;;;;;;metastasis;;drug resistance breast cancer;breast cancer;breast cancer;breast cancer;gastric cancer;sarcoma;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;lung squamous cell cancer hsa-miR-200c-3p ZEB1 2.07038651806183 6.84613386286599e-51 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.419256244047077 6.2413741334997e-52 24710933;24615544;21682933;27717206;23626803;27666124;23754305;24424572;24186205;22407310 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer metastasis;metastasis;drug resistance;;;;;;;;metastasis breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;lung cancer;kidney renal cell cancer;head and neck cancer;prostate cancer;colon cancer hsa-miR-429 ZEB1 2.84108892259147 3.88520896426515e-64 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.317045126675159 1.98180816866894e-44 26011542;27058893;26472725;24633485 Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;MiR-429 downstream target ZEB1 was decreased E-cadherin was restored and β-catenin was contrarily decreased by exogenous mimic of miR-429 treatment in T24 cells;Here we showed that miR-429 levels were significantly decreased and ZEB1 and ZEB2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and ZEB1 or ZEB2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-untranslated region of both ZEB1 and ZEB2 mRNA to inhibit their translation which was confirmed by luciferase reporter assay;In conclusion miR-429 serves as a tumor suppressor via interaction with ZEB1 ;;; breast cancer;bladder cancer;gastric cancer;sarcoma hsa-miR-96-5p ZEB1 3.24596558166606 1.92296159041707e-98 -1.20177694006781 1.58231961737395e-22 MirTarget;TargetScan;miRNATAP -0.278398602390555 6.88444571966269e-31 NA NA NA hsa-miR-141-3p ZEB2 2.99777540204168 1.26370498493024e-78 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.414576149422103 1.12624955121735e-83 25975736;18925646;24307282 These results suggest that miR‑141 may be involved in the inhibition of gastric cancer cell migration and that ZEB2 is a target gene of miR-141;TargetScan algorithm revealed that ZFHX1B mRNA is a hypothetical target of both miR-141 and -200c; We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2 cell migration;; gastric cancer;kidney renal cell cancer;sarcoma hsa-miR-183-5p ZEB2 2.95681814393872 1.09965777344285e-92 -1.60369039498659 1.13296131497065e-43 MirTarget;miRNATAP -0.3409157613271 2.10816971660002e-44 NA NA NA hsa-miR-200a-3p ZEB2 2.55218480823434 2.96135446816238e-51 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.34961751703046 1.4672767099241e-58 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200a-5p ZEB2 2.58844508672328 1.79650654234569e-56 -1.60369039498659 1.13296131497065e-43 miRNATAP -0.306453052202489 1.37797716580376e-41 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200b-3p ZEB2 2.11744072703209 1.66710572104191e-43 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget -0.387016799530245 6.18770056114522e-58 24518294;19787069;24815002;24424572;24769353;19854497;22311119;19544444 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Zinc finger E box binding homeobox 2 ZEB2 regulated by miR 200b contributes to multi drug resistance of small cell lung cancer; In silico analysis demonstrated that there are complementary binding sites between miR-200b and ZEB2 3'-UTR and identified miR-200b as a potential regulator of ZEB2; Overexpression of miR-200b led to the downregulation of ZEB2 at protein level; Luciferase reporter gene assay showed that 3'UTR ZEB2 activity was regulated by miR-200b; Our results suggest that ZEB2 modulates drug resistance and is regulated by miR-200b;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200b regulates cell proliferation invasion and migration by directly targeting ZEB2 in gastric carcinoma; There was a strong correlation between the levels of miR-200b and ZEB2 and E-cadherin mRNAs in gastric cancer patients; miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;metastasis;;tumorigenesis;drug resistance;;metastasis; breast cancer;breast cancer;sarcoma;head and neck cancer;lung squamous cell cancer;ovarian cancer;gastric cancer;prostate cancer hsa-miR-200c-3p ZEB2 2.07038651806183 6.84613386286599e-51 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.472673002772748 6.29752478367514e-74 24710933;21682933;26935975;25052237;18925646;24885194 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT metastasis;;metastasis;metastasis;; breast cancer;breast cancer;lung squamous cell cancer;ovarian cancer;kidney renal cell cancer;gastric cancer hsa-miR-375 ZEB2 2.09893673049766 1.68351780396203e-16 -1.60369039498659 1.13296131497065e-43 miRanda -0.141650858820113 2.73776967382215e-19 NA NA NA hsa-miR-429 ZEB2 2.84108892259147 3.88520896426515e-64 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.34052674454868 4.92266469556256e-56 26472725 Here we showed that miR-429 levels were significantly decreased and ZEB1 and ZEB2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and ZEB1 or ZEB2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-untranslated region of both ZEB1 and ZEB2 mRNA to inhibit their translation which was confirmed by luciferase reporter assay gastric cancer hsa-miR-141-3p ZFAND5 2.99777540204168 1.26370498493024e-78 -0.766253985974807 3.5779186180608e-35 TargetScan -0.116168365027361 2.44865271331215e-21 NA NA NA hsa-miR-200a-5p ZFAND5 2.58844508672328 1.79650654234569e-56 -0.766253985974807 3.5779186180608e-35 mirMAP -0.113184704576029 4.22258326442107e-20 NA NA NA hsa-miR-200b-3p ZFAND5 2.11744072703209 1.66710572104191e-43 -0.766253985974807 3.5779186180608e-35 TargetScan;mirMAP -0.129350741948338 3.37113357844796e-22 NA NA NA hsa-miR-200c-3p ZFAND5 2.07038651806183 6.84613386286599e-51 -0.766253985974807 3.5779186180608e-35 mirMAP -0.151662102554221 3.34088379228113e-25 NA NA NA hsa-miR-429 ZFAND5 2.84108892259147 3.88520896426515e-64 -0.766253985974807 3.5779186180608e-35 PITA;mirMAP -0.10505768213566 1.80716095728657e-18 NA NA NA hsa-miR-96-5p ZFAND5 3.24596558166606 1.92296159041707e-98 -0.766253985974807 3.5779186180608e-35 TargetScan -0.10548861551929 3.75420944922904e-17 NA NA NA hsa-miR-141-3p ZFHX3 2.99777540204168 1.26370498493024e-78 -0.348999974902257 0.000181853915066663 miRNATAP -0.105617559526677 4.67669171720679e-09 NA NA NA hsa-miR-200a-3p ZFHX3 2.55218480823434 2.96135446816238e-51 -0.348999974902257 0.000181853915066663 miRNATAP -0.1268923645581 5.54301903305533e-13 NA NA NA hsa-miR-429 ZFHX3 2.84108892259147 3.88520896426515e-64 -0.348999974902257 0.000181853915066663 miRNATAP -0.116537126417593 2.86932489905777e-11 NA NA NA hsa-miR-183-5p ZFHX4 2.95681814393872 1.09965777344285e-92 -1.53229883683245 2.36314851813226e-21 miRNAWalker2_validate -0.33932827783889 1.79758532833339e-23 NA NA NA hsa-miR-200b-3p ZFHX4 2.11744072703209 1.66710572104191e-43 -1.53229883683245 2.36314851813226e-21 TargetScan -0.426760636969311 6.05019178192894e-37 NA NA NA hsa-miR-200c-3p ZFHX4 2.07038651806183 6.84613386286599e-51 -1.53229883683245 2.36314851813226e-21 miRNATAP -0.513283024255035 1.0110518194279e-44 NA NA NA hsa-miR-429 ZFHX4 2.84108892259147 3.88520896426515e-64 -1.53229883683245 2.36314851813226e-21 miRanda;miRNATAP -0.393795217705459 1.35199072602587e-39 NA NA NA hsa-miR-96-5p ZFHX4 3.24596558166606 1.92296159041707e-98 -1.53229883683245 2.36314851813226e-21 MirTarget;TargetScan;miRNATAP -0.365703231501742 4.98854285765332e-31 NA NA NA hsa-miR-452-5p ZFP30 -2.48486455572568 1.24430987974325e-33 0.221643474558477 0.0088929656439856 mirMAP -0.123668857632649 8.89039560789889e-21 NA NA NA hsa-miR-429 ZFP36 2.84108892259147 3.88520896426515e-64 -2.06391193424656 7.68177594121862e-47 miRanda -0.293648778562571 9.81577157928667e-26 NA NA NA hsa-miR-96-5p ZFP36 3.24596558166606 1.92296159041707e-98 -2.06391193424656 7.68177594121862e-47 miRNATAP -0.361544558927893 4.4817429048694e-36 NA NA NA hsa-miR-182-5p ZFP36L1 2.36408084103818 2.60011457600281e-72 -0.771288555846175 3.32327974284759e-18 miRNATAP -0.15647823692806 1.88471400718534e-13 NA NA NA hsa-miR-429 ZFP36L1 2.84108892259147 3.88520896426515e-64 -0.771288555846175 3.32327974284759e-18 miRanda;miRNATAP -0.14238087065864 2.57569717136841e-17 NA NA NA hsa-miR-96-5p ZFP36L1 3.24596558166606 1.92296159041707e-98 -0.771288555846175 3.32327974284759e-18 TargetScan;miRNATAP -0.165333680115223 2.91802626124595e-21 NA NA NA hsa-miR-21-5p ZFP36L2 2.32007501846389 3.08394781855554e-137 -1.20951272849442 2.78264800572534e-33 MirTarget -0.198642857440537 8.52276974415143e-10 NA NA NA hsa-miR-375 ZFP36L2 2.09893673049766 1.68351780396203e-16 -1.20951272849442 2.78264800572534e-33 miRNAWalker2_validate;miRanda -0.138680538757387 5.26048421392882e-25 NA NA NA hsa-miR-429 ZFP36L2 2.84108892259147 3.88520896426515e-64 -1.20951272849442 2.78264800572534e-33 miRanda;miRNATAP -0.192945124448946 1.76858096632484e-23 NA NA NA hsa-miR-96-5p ZFP36L2 3.24596558166606 1.92296159041707e-98 -1.20951272849442 2.78264800572534e-33 TargetScan -0.230129258082881 1.0583889565726e-30 NA NA NA hsa-miR-141-3p ZFP37 2.99777540204168 1.26370498493024e-78 -1.14029646756092 1.53251959177574e-19 mirMAP -0.162671206194914 5.62333946855471e-11 NA NA NA hsa-miR-200a-3p ZFP37 2.55218480823434 2.96135446816238e-51 -1.14029646756092 1.53251959177574e-19 mirMAP -0.140752734851935 8.25573831207691e-09 NA NA NA hsa-miR-200b-3p ZFP37 2.11744072703209 1.66710572104191e-43 -1.14029646756092 1.53251959177574e-19 mirMAP -0.121061802933701 9.03543574277254e-06 NA NA NA hsa-miR-200c-3p ZFP37 2.07038651806183 6.84613386286599e-51 -1.14029646756092 1.53251959177574e-19 mirMAP -0.15694530363449 1.55941572383231e-07 NA NA NA hsa-miR-429 ZFP37 2.84108892259147 3.88520896426515e-64 -1.14029646756092 1.53251959177574e-19 mirMAP -0.142451836116676 4.2284187298495e-09 NA NA NA hsa-miR-10b-5p ZFP41 -2.10996264627796 7.36811595736367e-72 0.64904010516701 1.98440355952371e-16 mirMAP -0.13707740289248 1.0034563944312e-10 NA NA NA hsa-miR-141-3p ZFPM2 2.99777540204168 1.26370498493024e-78 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase -0.42417105347186 3.00194018110561e-51 NA NA NA hsa-miR-183-5p ZFPM2 2.95681814393872 1.09965777344285e-92 -1.48309651759718 5.26430774358294e-23 miRNATAP -0.318025439787394 9.58894483742208e-24 NA NA NA hsa-miR-200a-3p ZFPM2 2.55218480823434 2.96135446816238e-51 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase -0.372246535238814 3.0832686353886e-40 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 2.11744072703209 1.66710572104191e-43 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase;TargetScan -0.40035042800184 1.77712326643107e-37 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200c-3p ZFPM2 2.07038651806183 6.84613386286599e-51 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.48840691534348 8.2725500362134e-47 NA NA NA hsa-miR-429 ZFPM2 2.84108892259147 3.88520896426515e-64 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.361689306845656 2.07789158653576e-38 NA NA NA hsa-miR-141-5p ZFYVE9 2.38411349683216 4.56310582620282e-58 -0.939573500122968 2.06592186129356e-21 MirTarget;miRNATAP -0.10090128380654 3.27275738623532e-06 NA NA NA hsa-miR-429 ZFYVE9 2.84108892259147 3.88520896426515e-64 -0.939573500122968 2.06592186129356e-21 miRNATAP -0.138287827425906 2.91796972669215e-13 NA NA NA hsa-miR-335-5p ZG16B -2.61355235628987 2.6462884165886e-51 2.10131079516227 4.43238183687088e-17 miRNAWalker2_validate -0.141252410582781 0.00288006095785189 NA NA NA hsa-miR-182-5p ZHX1 2.36408084103818 2.60011457600281e-72 -0.650033710943124 8.31707042418316e-15 miRNATAP -0.134950548371161 1.68357505979918e-11 NA NA NA hsa-miR-96-5p ZHX1 3.24596558166606 1.92296159041707e-98 -0.650033710943124 8.31707042418316e-15 TargetScan;miRNATAP -0.114137296904562 6.65492476379398e-12 NA NA NA hsa-miR-21-3p ZHX3 2.17476065946878 5.15299442583591e-75 -1.02353107616406 7.94422939009349e-43 mirMAP -0.212445116038627 3.63143325319024e-26 NA NA NA hsa-miR-96-5p ZHX3 3.24596558166606 1.92296159041707e-98 -1.02353107616406 7.94422939009349e-43 mirMAP -0.158988394894896 5.58294513115594e-26 NA NA NA hsa-miR-375 ZIC1 2.09893673049766 1.68351780396203e-16 0.188842363843119 0.617056839930357 MirTarget;miRanda -0.418569057856771 1.02917524809615e-17 NA NA NA hsa-miR-375 ZIC5 2.09893673049766 1.68351780396203e-16 -0.155330414624192 0.63062439709307 miRanda -0.194325505793052 4.62657032376942e-06 NA NA NA hsa-miR-200a-3p ZIK1 2.55218480823434 2.96135446816238e-51 -1.18368348590858 8.05676664177545e-12 mirMAP -0.154657116864388 3.43609818333755e-06 NA NA NA hsa-miR-429 ZIK1 2.84108892259147 3.88520896426515e-64 -1.18368348590858 8.05676664177545e-12 mirMAP -0.168336444214272 3.49092391630787e-07 NA NA NA hsa-miR-452-5p ZKSCAN1 -2.48486455572568 1.24430987974325e-33 -0.295524595321098 0.0174764449978345 MirTarget -0.106852170549426 6.37632669942877e-08 NA NA NA hsa-miR-182-5p ZMAT3 2.36408084103818 2.60011457600281e-72 -0.969402662641862 2.08248828196627e-18 mirMAP -0.210572682512156 2.02994355290918e-15 NA NA NA hsa-miR-200b-3p ZMAT3 2.11744072703209 1.66710572104191e-43 -0.969402662641862 2.08248828196627e-18 MirTarget;TargetScan -0.199434002125701 2.48176000863477e-17 NA NA NA hsa-miR-200c-3p ZMAT3 2.07038651806183 6.84613386286599e-51 -0.969402662641862 2.08248828196627e-18 MirTarget -0.202683466626764 6.09304654624938e-15 NA NA NA hsa-miR-429 ZMAT3 2.84108892259147 3.88520896426515e-64 -0.969402662641862 2.08248828196627e-18 MirTarget;miRNATAP -0.189721172084985 1.44816040795263e-19 NA NA NA hsa-miR-452-5p ZMAT4 -2.48486455572568 1.24430987974325e-33 0.495898806265274 0.0940540099725488 MirTarget -0.235747026550811 5.59038861592137e-07 NA NA NA hsa-miR-21-5p ZMYM2 2.32007501846389 3.08394781855554e-137 -0.100771952932536 0.181356345393863 miRNAWalker2_validate -0.127847914107643 4.1156900196522e-08 NA NA NA hsa-miR-486-5p ZMYND19 -3.87258704301474 1.22658629378451e-80 1.16735293189122 1.15467709764915e-43 miRanda -0.1007943745225 3.66857684881897e-14 NA NA NA hsa-miR-183-5p ZNF154 2.95681814393872 1.09965777344285e-92 -1.49953992809858 2.51335795582447e-25 mirMAP -0.260857468186725 2.19903606221318e-17 NA NA NA hsa-miR-96-5p ZNF175 3.24596558166606 1.92296159041707e-98 -0.85159954018995 3.00650550160035e-15 MirTarget -0.125569693239766 5.52336540787525e-09 NA NA NA hsa-miR-21-5p ZNF208 2.32007501846389 3.08394781855554e-137 -1.63678555623493 1.18452180708522e-13 mirMAP -0.292098132572268 2.73952563823386e-05 NA NA NA hsa-miR-486-5p ZNF213 -3.87258704301474 1.22658629378451e-80 0.815173882617804 1.0312379018424e-32 miRanda -0.112201326754086 9.04112215533386e-27 NA NA NA hsa-miR-429 ZNF215 2.84108892259147 3.88520896426515e-64 -0.744517524217747 1.87261161891389e-06 miRanda -0.172276624503324 5.40332049691381e-09 NA NA NA hsa-miR-21-5p ZNF24 2.32007501846389 3.08394781855554e-137 0.0144322494310973 0.852805094597304 mirMAP -0.125588812465726 1.77902479130186e-07 NA NA NA hsa-miR-21-3p ZNF248 2.17476065946878 5.15299442583591e-75 -0.425319508659094 9.08677372822487e-15 MirTarget -0.10407642507565 6.0581310040587e-13 NA NA NA hsa-miR-139-5p ZNF260 -3.25846663863766 2.62018989415003e-112 0.271206070052603 4.80334533332787e-05 miRanda -0.104700845235579 1.12569951244763e-14 NA NA NA hsa-miR-182-5p ZNF280B 2.36408084103818 2.60011457600281e-72 -0.633283900187614 0.00108318841614157 MirTarget -0.275432763731457 1.97333887833538e-09 NA NA NA hsa-miR-96-5p ZNF280B 3.24596558166606 1.92296159041707e-98 -0.633283900187614 0.00108318841614157 TargetScan -0.162025450080152 2.32444235344236e-05 NA NA NA hsa-miR-21-5p ZNF280D 2.32007501846389 3.08394781855554e-137 -0.748812538080762 2.04661149010264e-30 mirMAP -0.274915560298223 6.6200396195592e-43 NA NA NA hsa-miR-21-5p ZNF292 2.32007501846389 3.08394781855554e-137 -0.652785758798692 1.63789336790459e-12 miRNAWalker2_validate -0.228561666670143 1.72761239251222e-15 NA NA NA hsa-miR-429 ZNF300 2.84108892259147 3.88520896426515e-64 -0.96454485350025 8.88887075701663e-11 miRanda -0.112405936465943 7.70421544505266e-05 NA NA NA hsa-miR-429 ZNF366 2.84108892259147 3.88520896426515e-64 -2.19272644755872 1.25764325204059e-34 miRanda -0.420564520081623 1.95338787872031e-35 NA NA NA hsa-miR-10b-5p ZNF367 -2.10996264627796 7.36811595736367e-72 1.39387374680686 2.2981931720078e-32 miRNATAP -0.401539113502437 5.49259957659867e-38 NA NA NA hsa-miR-139-5p ZNF367 -3.25846663863766 2.62018989415003e-112 1.39387374680686 2.2981931720078e-32 miRanda -0.290922008232318 3.16455299106655e-33 NA NA NA hsa-miR-486-5p ZNF367 -3.87258704301474 1.22658629378451e-80 1.39387374680686 2.2981931720078e-32 PITA;miRanda;miRNATAP -0.122315584151241 3.01108011155627e-11 NA NA NA hsa-miR-99a-5p ZNF367 -2.25079447371102 1.14086813185885e-54 1.39387374680686 2.2981931720078e-32 miRNAWalker2_validate -0.336786645816699 1.01782776703903e-38 NA NA NA hsa-miR-141-3p ZNF385D 2.99777540204168 1.26370498493024e-78 -1.58947730363585 5.76650731569701e-16 MirTarget;TargetScan -0.360073937754939 2.41239444277846e-21 NA NA NA hsa-miR-200a-3p ZNF385D 2.55218480823434 2.96135446816238e-51 -1.58947730363585 5.76650731569701e-16 MirTarget -0.246039133337274 7.25814323833198e-11 NA NA NA hsa-miR-183-5p ZNF395 2.95681814393872 1.09965777344285e-92 -0.837643450913783 2.35009090977746e-22 mirMAP -0.141451088778156 1.2573196088466e-14 NA NA NA hsa-miR-141-3p ZNF423 2.99777540204168 1.26370498493024e-78 -1.54184148419144 6.10940404866175e-27 mirMAP -0.443714575964303 3.80042072328937e-62 NA NA NA hsa-miR-182-5p ZNF423 2.36408084103818 2.60011457600281e-72 -1.54184148419144 6.10940404866175e-27 mirMAP -0.247664264056272 1.25275151350125e-12 NA NA NA hsa-miR-200a-3p ZNF423 2.55218480823434 2.96135446816238e-51 -1.54184148419144 6.10940404866175e-27 mirMAP -0.372654728096588 5.47923871796623e-44 NA NA NA hsa-miR-200b-3p ZNF423 2.11744072703209 1.66710572104191e-43 -1.54184148419144 6.10940404866175e-27 MirTarget;TargetScan -0.383229276436197 3.18182871747426e-37 NA NA NA hsa-miR-200c-3p ZNF423 2.07038651806183 6.84613386286599e-51 -1.54184148419144 6.10940404866175e-27 MirTarget -0.474923989134754 4.18879723474327e-48 NA NA NA hsa-miR-429 ZNF423 2.84108892259147 3.88520896426515e-64 -1.54184148419144 6.10940404866175e-27 MirTarget;PITA;miRanda;miRNATAP -0.36116711475755 9.82443020425765e-42 NA NA NA hsa-miR-141-3p ZNF436 2.99777540204168 1.26370498493024e-78 -0.664338506334725 2.34102543837604e-20 TargetScan -0.109198783723963 8.38416009631772e-15 NA NA NA hsa-miR-21-5p ZNF449 2.32007501846389 3.08394781855554e-137 -0.510562727174373 6.01736777734132e-16 MirTarget -0.155315166183741 2.94822810873481e-15 NA NA NA hsa-miR-21-5p ZNF451 2.32007501846389 3.08394781855554e-137 -0.40457873774092 1.57817261720625e-12 mirMAP -0.198706768089808 3.54655918991468e-30 NA NA NA hsa-miR-375 ZNF462 2.09893673049766 1.68351780396203e-16 -1.85020093931925 1.93274868933039e-26 miRanda;miRNATAP -0.233090473292586 4.63942888439584e-24 NA NA NA hsa-miR-429 ZNF462 2.84108892259147 3.88520896426515e-64 -1.85020093931925 1.93274868933039e-26 miRNATAP -0.220591922126621 5.66878238800345e-11 NA NA NA hsa-miR-200a-5p ZNF471 2.58844508672328 1.79650654234569e-56 -1.56014712277337 1.10808522377177e-22 mirMAP -0.152920259954642 1.51972080050681e-06 NA NA NA hsa-miR-429 ZNF483 2.84108892259147 3.88520896426515e-64 -1.79302155637936 8.09598164766452e-31 miRanda -0.200461650574733 3.37920489612634e-11 NA NA NA hsa-miR-378a-5p ZNF500 -2.43173551693523 1.44932837789175e-68 0.371749530394336 1.31282654910857e-08 mirMAP -0.198458012798935 5.86650398379399e-45 NA NA NA hsa-miR-224-5p ZNF516 -2.22249420723892 1.07787949391113e-18 -0.250262030400588 0.0726799158721395 mirMAP -0.158601315685328 2.64263009341449e-18 NA NA NA hsa-miR-452-5p ZNF516 -2.48486455572568 1.24430987974325e-33 -0.250262030400588 0.0726799158721395 MirTarget -0.1807599861786 1.4900101495342e-16 NA NA NA hsa-miR-429 ZNF521 2.84108892259147 3.88520896426515e-64 -1.40343600241071 4.10945056576502e-23 miRanda;miRNATAP -0.238369215628916 1.20058169058493e-18 NA NA NA hsa-miR-452-5p ZNF525 -2.48486455572568 1.24430987974325e-33 0.585986404904445 3.32272758342467e-13 mirMAP -0.131502479503424 2.87908101419079e-25 NA NA NA hsa-miR-21-5p ZNF527 2.32007501846389 3.08394781855554e-137 -0.380241997939519 1.10441083440784e-10 MirTarget -0.182678619109294 3.86904549803528e-24 NA NA NA hsa-miR-224-5p ZNF528 -2.22249420723892 1.07787949391113e-18 -0.24351660653811 0.0311054836929072 MirTarget -0.125952746282243 1.29139431800102e-17 NA NA NA hsa-miR-182-5p ZNF532 2.36408084103818 2.60011457600281e-72 -0.486598759081946 3.90195954090326e-08 miRNATAP -0.133236311984478 2.45929499825963e-10 NA NA NA hsa-miR-200b-3p ZNF532 2.11744072703209 1.66710572104191e-43 -0.486598759081946 3.90195954090326e-08 MirTarget;TargetScan -0.117205676654703 4.02285501003701e-10 NA NA NA hsa-miR-200c-3p ZNF532 2.07038651806183 6.84613386286599e-51 -0.486598759081946 3.90195954090326e-08 MirTarget;miRNATAP -0.123884613316905 1.91112549184569e-09 NA NA NA hsa-miR-96-5p ZNF532 3.24596558166606 1.92296159041707e-98 -0.486598759081946 3.90195954090326e-08 TargetScan;miRNATAP -0.103829170487711 2.91614132448668e-09 NA NA NA hsa-miR-335-5p ZNF579 -2.61355235628987 2.6462884165886e-51 1.13007812371013 1.54230491659638e-21 miRNAWalker2_validate -0.164731543143827 1.43822358580675e-13 NA NA NA hsa-miR-145-5p ZNF593 -2.62703571936687 7.64402900188551e-88 1.03258130709114 2.89883174627819e-20 MirTarget -0.265023606855147 1.3390858228511e-24 NA NA NA hsa-miR-335-5p ZNF598 -2.61355235628987 2.6462884165886e-51 1.00027066660524 1.50842371987224e-37 miRNAWalker2_validate -0.155922882741624 3.52532332306544e-26 NA NA NA hsa-miR-141-3p ZNF608 2.99777540204168 1.26370498493024e-78 -1.41003746006724 7.06391794802511e-20 miRNATAP -0.245314872877093 4.82942927594483e-16 NA NA NA hsa-miR-200a-3p ZNF608 2.55218480823434 2.96135446816238e-51 -1.41003746006724 7.06391794802511e-20 miRNATAP -0.170130673047596 1.34209802137876e-08 NA NA NA hsa-miR-429 ZNF608 2.84108892259147 3.88520896426515e-64 -1.41003746006724 7.06391794802511e-20 miRanda;miRNATAP -0.18222607943884 8.46593680002027e-10 NA NA NA hsa-miR-378a-5p ZNF629 -2.43173551693523 1.44932837789175e-68 0.466210287318572 5.01414419404844e-13 mirMAP -0.196344235385039 1.17157789296531e-44 NA NA NA hsa-miR-141-3p ZNF641 2.99777540204168 1.26370498493024e-78 -0.634238399739506 4.03050324313056e-09 TargetScan -0.105985314592127 4.68550155783422e-07 NA NA NA hsa-miR-429 ZNF641 2.84108892259147 3.88520896426515e-64 -0.634238399739506 4.03050324313056e-09 miRanda;miRNATAP -0.118503914945752 6.79725392975827e-09 NA NA NA hsa-miR-378a-5p ZNF646 -2.43173551693523 1.44932837789175e-68 0.504111978333149 1.71759628287416e-15 miRNAWalker2_validate -0.1730033894957 2.80140079056999e-35 NA NA NA hsa-miR-21-5p ZNF654 2.32007501846389 3.08394781855554e-137 -0.390659492780361 7.53372567548898e-09 miRNATAP -0.173363422506433 8.99558510587105e-17 NA NA NA hsa-miR-141-3p ZNF660 2.99777540204168 1.26370498493024e-78 -1.67734593603041 3.35110996992824e-30 TargetScan -0.32129698453234 3.12847376313803e-29 NA NA NA hsa-miR-429 ZNF660 2.84108892259147 3.88520896426515e-64 -1.67734593603041 3.35110996992824e-30 miRanda -0.263956701150393 8.1350019523833e-21 NA NA NA hsa-miR-183-5p ZNF662 2.95681814393872 1.09965777344285e-92 -1.6024130657216 1.19420572254461e-23 MirTarget -0.236497468755054 5.08683697808401e-12 NA NA NA hsa-miR-200b-3p ZNF662 2.11744072703209 1.66710572104191e-43 -1.6024130657216 1.19420572254461e-23 TargetScan -0.117742703739421 0.000729368283773752 NA NA NA hsa-miR-429 ZNF662 2.84108892259147 3.88520896426515e-64 -1.6024130657216 1.19420572254461e-23 miRanda -0.157836160523574 3.52010635547502e-07 NA NA NA hsa-miR-21-5p ZNF667 2.32007501846389 3.08394781855554e-137 -1.60334457442293 8.82568093980352e-19 miRNAWalker2_validate -0.428272360487598 5.30837794649517e-14 NA NA NA hsa-miR-429 ZNF667 2.84108892259147 3.88520896426515e-64 -1.60334457442293 8.82568093980352e-19 miRanda -0.149436820997987 1.93857564677424e-05 NA NA NA hsa-miR-96-5p ZNF667 3.24596558166606 1.92296159041707e-98 -1.60334457442293 8.82568093980352e-19 MirTarget -0.246740847573935 9.52207850545525e-12 NA NA NA hsa-miR-200a-5p ZNF677 2.58844508672328 1.79650654234569e-56 -1.96909501423383 5.5558801962152e-38 mirMAP -0.260021283332409 2.54450301739864e-17 NA NA NA hsa-miR-21-5p ZNF680 2.32007501846389 3.08394781855554e-137 -0.0871829114633575 0.348284394813858 MirTarget -0.13816350545046 1.61216030110629e-06 NA NA NA hsa-miR-452-5p ZNF681 -2.48486455572568 1.24430987974325e-33 0.93981109297173 4.50084443455848e-19 mirMAP -0.16205399881066 4.53527617414641e-22 NA NA NA hsa-miR-141-3p ZNF704 2.99777540204168 1.26370498493024e-78 -1.29804603210391 1.17161901097451e-16 TargetScan -0.255024301253743 5.95460445406741e-17 NA NA NA hsa-miR-182-5p ZNF704 2.36408084103818 2.60011457600281e-72 -1.29804603210391 1.17161901097451e-16 mirMAP;miRNATAP -0.214555495591602 1.35710139847728e-08 NA NA NA hsa-miR-200b-3p ZNF704 2.11744072703209 1.66710572104191e-43 -1.29804603210391 1.17161901097451e-16 mirMAP -0.268391382229473 7.83167159621181e-16 NA NA NA hsa-miR-200c-3p ZNF704 2.07038651806183 6.84613386286599e-51 -1.29804603210391 1.17161901097451e-16 mirMAP -0.24177900119246 5.45204870284249e-11 NA NA NA hsa-miR-21-5p ZNF704 2.32007501846389 3.08394781855554e-137 -1.29804603210391 1.17161901097451e-16 MirTarget;miRNATAP -0.383066314653317 5.420261673963e-15 NA NA NA hsa-miR-429 ZNF704 2.84108892259147 3.88520896426515e-64 -1.29804603210391 1.17161901097451e-16 mirMAP;miRNATAP -0.26145555918126 1.11911391671217e-18 NA NA NA hsa-miR-96-5p ZNF704 3.24596558166606 1.92296159041707e-98 -1.29804603210391 1.17161901097451e-16 TargetScan;miRNATAP -0.256549256596724 1.33126434894355e-16 NA NA NA hsa-miR-429 ZNF711 2.84108892259147 3.88520896426515e-64 -1.11353126597736 6.502944431144e-09 MirTarget;miRanda;miRNATAP -0.101433483384047 0.00568862487172157 NA NA NA hsa-miR-335-5p ZNF771 -2.61355235628987 2.6462884165886e-51 1.11279786014984 2.33772331433205e-26 miRNAWalker2_validate -0.174385131477596 7.71304411190346e-19 NA NA NA hsa-miR-21-3p ZNF772 2.17476065946878 5.15299442583591e-75 -0.233166635600139 0.049687043136847 mirMAP -0.151278974064101 1.17396431020688e-06 NA NA NA hsa-miR-21-3p ZNF780B 2.17476065946878 5.15299442583591e-75 -0.534440131714969 4.26505882432315e-11 mirMAP -0.155217935019644 3.0025217762592e-13 NA NA NA hsa-miR-224-5p ZNF785 -2.22249420723892 1.07787949391113e-18 0.367549846675363 8.2446831867917e-07 mirMAP -0.112145556590676 1.52405234176756e-31 NA NA NA hsa-miR-429 ZNF831 2.84108892259147 3.88520896426515e-64 -0.717347768992676 0.00103573267029792 miRanda -0.188554007710065 5.15206128234797e-06 NA NA NA hsa-miR-139-5p ZNF93 -3.25846663863766 2.62018989415003e-112 0.787583139734471 1.86222654115515e-14 miRanda -0.200429421025694 1.28228654788267e-21 NA NA NA hsa-miR-335-5p ZPLD1 -2.61355235628987 2.6462884165886e-51 0.924336510646481 0.000590121243414734 miRNAWalker2_validate -0.188299280985195 0.000167185875015343 NA NA NA hsa-miR-21-5p ZRANB1 2.32007501846389 3.08394781855554e-137 -0.497806163532093 9.97509660833851e-21 miRNAWalker2_validate -0.202730374513769 1.19486880747037e-35 NA NA NA hsa-miR-141-3p ZSCAN23 2.99777540204168 1.26370498493024e-78 -2.20639914562817 4.5304461048684e-22 miRNATAP -0.367100379744908 2.59638181469388e-16 NA NA NA hsa-miR-200a-3p ZSCAN23 2.55218480823434 2.96135446816238e-51 -2.20639914562817 4.5304461048684e-22 miRNATAP -0.279333873604319 2.9414977183278e-10 NA NA NA hsa-miR-224-5p ZSWIM5 -2.22249420723892 1.07787949391113e-18 -0.451593352623076 0.00950484344118356 mirMAP -0.232256946419488 6.4071630082942e-25 NA NA NA hsa-miR-21-5p ZSWIM6 2.32007501846389 3.08394781855554e-137 -0.112225093273613 0.194358643248745 MirTarget;miRNATAP -0.134737304178267 4.86561659146438e-07 NA NA NA hsa-miR-141-3p ZYG11B 2.99777540204168 1.26370498493024e-78 -0.676145891271205 1.48820420419549e-24 MirTarget -0.118086071735268 6.40322611989954e-20 NA NA NA hsa-miR-200a-3p ZYG11B 2.55218480823434 2.96135446816238e-51 -0.676145891271205 1.48820420419549e-24 MirTarget -0.11545389241864 8.69498098202584e-20 NA NA NA hsa-miR-200b-3p ZYG11B 2.11744072703209 1.66710572104191e-43 -0.676145891271205 1.48820420419549e-24 TargetScan -0.136849496014765 2.11476478030754e-22 NA NA NA hsa-miR-21-5p ZYG11B 2.32007501846389 3.08394781855554e-137 -0.676145891271205 1.48820420419549e-24 miRNAWalker2_validate;mirMAP -0.237515753823477 2.72630953319275e-31 NA NA NA hsa-miR-429 ZYG11B 2.84108892259147 3.88520896426515e-64 -0.676145891271205 1.48820420419549e-24 miRanda;miRNATAP -0.108841265855288 6.69420348108621e-18 NA NA NA