miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-105-5p AKT2 -0.567459149851677 8.20858944634795e-06 0.139361896216647 0.0151763675439579 mirMAP -0.11517777162873 2.5456118337521e-14 NA NA NA hsa-miR-146b-5p AKT3 0.441078059667297 0.000237619929889385 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate -0.14853390000962 1.54850741316524e-10 NA NA NA hsa-miR-15a-5p AKT3 0.142658985373611 0.0536219185009004 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171093255137198 0.000104922528677221 NA NA NA hsa-miR-15b-5p AKT3 0.592863156692837 1.41971517354055e-10 -0.235109681312394 0.000861339724103604 miRNATAP -0.149023414077877 1.00397425898265e-06 NA NA NA hsa-miR-28-3p AKT3 0.139444423971018 0.0811187936164314 -0.235109681312394 0.000861339724103604 miRNATAP -0.281326919526608 6.94030005162363e-11 NA NA NA hsa-miR-320a AKT3 0.092135599636725 0.243028758989929 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.162091233103736 0.000150010109497495 NA NA NA hsa-miR-320c AKT3 0.343259124189966 0.000248338401291051 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.11345587888064 0.000121683825333423 NA NA NA hsa-miR-362-3p AKT3 0.032375035235532 0.736465332563774 -0.235109681312394 0.000861339724103604 miRanda -0.133145359057788 1.93504628679194e-06 NA NA NA hsa-miR-362-5p AKT3 -0.0730185557229279 0.425572997292224 -0.235109681312394 0.000861339724103604 PITA;TargetScan;miRNATAP -0.12269062278053 4.12753291036148e-05 NA NA NA hsa-miR-501-3p AKT3 0.0726267165568464 0.382729320534971 -0.235109681312394 0.000861339724103604 miRNATAP -0.230986821283872 3.52473505159126e-12 NA NA NA hsa-miR-502-3p AKT3 0.0276791089364088 0.697605011368848 -0.235109681312394 0.000861339724103604 miRNATAP -0.217874003496912 1.14360007951059e-08 NA NA NA hsa-miR-93-5p AKT3 0.139766237971122 0.101057320076629 -0.235109681312394 0.000861339724103604 miRNATAP -0.208262975522215 1.91431764461584e-05 NA NA NA hsa-miR-155-5p CAB39L 0.969837380981085 5.86551495710056e-15 -0.400174945409539 3.47308140137677e-07 miRNAWalker2_validate -0.107737398698819 1.40658190947599e-05 NA NA NA hsa-miR-542-3p CAB39L 0.0835995677900829 0.403838744494071 -0.400174945409539 3.47308140137677e-07 miRanda -0.324112955013057 9.86194767099553e-22 NA NA NA hsa-miR-582-5p CAB39L -0.215764335500665 0.0760892640434509 -0.400174945409539 3.47308140137677e-07 miRNATAP -0.114011221632209 9.95289397677541e-06 NA NA NA hsa-miR-199a-3p DDIT4 0.41226331871076 0.000497136154474528 -0.340397632296293 0.000585933470156393 MirTarget;PITA;miRNATAP -0.111921365809488 0.000693312425856822 NA NA NA hsa-miR-199b-3p DDIT4 0.411848361704393 0.000517815011892379 -0.340397632296293 0.000585933470156393 MirTarget;PITA;miRNATAP -0.11139228035532 0.000715052576128095 NA NA NA hsa-miR-200b-3p DDIT4 0.245768526504511 0.0580744465744737 -0.340397632296293 0.000585933470156393 TargetScan -0.153499343055954 3.41119820060798e-07 NA NA NA hsa-miR-22-3p DDIT4 0.0277287593466351 0.809325106832648 -0.340397632296293 0.000585933470156393 MirTarget -0.171981785044227 0.000216459041504238 NA NA NA hsa-miR-221-3p DDIT4 -0.0109507285071775 0.936440693394519 -0.340397632296293 0.000585933470156393 miRNAWalker2_validate;miRTarBase -0.145187258070452 2.6360324492418e-07 NA NA NA hsa-miR-30e-5p DDIT4 0.0764521828640934 0.41904991629622 -0.340397632296293 0.000585933470156393 MirTarget -0.272101656619712 1.98107108612766e-06 NA NA NA hsa-miR-32-5p DDIT4 0.130313603388223 0.177843055266148 -0.340397632296293 0.000585933470156393 miRNATAP -0.10594411203117 0.00931945355896724 NA NA NA hsa-miR-103a-3p EIF4B -0.147443193527362 0.128400914654149 -0.152061905713888 0.0271875624306495 MirTarget;miRNATAP -0.283333004226312 3.03876316241244e-14 NA NA NA hsa-miR-107 EIF4B -0.121070851008387 0.198381281894242 -0.152061905713888 0.0271875624306495 MirTarget;PITA;miRanda;miRNATAP -0.129970286069417 1.54239548429985e-07 NA NA NA hsa-miR-149-5p EIF4B -0.0535821592029952 0.657713892012548 -0.152061905713888 0.0271875624306495 miRNAWalker2_validate;miRNATAP -0.165366935947129 6.22748422667344e-20 NA NA NA hsa-miR-15a-5p EIF4B 0.142658985373611 0.0536219185009004 -0.152061905713888 0.0271875624306495 miRNATAP -0.162339529170139 7.00813946895071e-06 NA NA NA hsa-miR-15b-5p EIF4B 0.592863156692837 1.41971517354055e-10 -0.152061905713888 0.0271875624306495 miRNATAP -0.169525586751993 7.37762490301615e-12 NA NA NA hsa-miR-185-5p EIF4B -0.0767432095218297 0.404113540276816 -0.152061905713888 0.0271875624306495 MirTarget -0.148325648817469 3.9428302535025e-09 NA NA NA hsa-miR-193a-3p EIF4B 0.395602305834739 0.00182611787714301 -0.152061905713888 0.0271875624306495 miRanda -0.12214409249832 2.91315524752069e-12 NA NA NA hsa-miR-193b-3p EIF4B 0.0766333116224072 0.324723824453143 -0.152061905713888 0.0271875624306495 miRNAWalker2_validate -0.156269361900307 1.53717834593784e-07 NA NA NA hsa-miR-25-3p EIF4B 0.316649850160985 0.000777982468387578 -0.152061905713888 0.0271875624306495 miRNAWalker2_validate -0.108167672109265 0.000434907765781561 NA NA NA hsa-miR-30a-3p EIF4B 0.0655410309550977 0.509541256241954 -0.152061905713888 0.0271875624306495 mirMAP -0.235668851050448 8.2988039215685e-17 NA NA NA hsa-miR-30d-3p EIF4B 0.0854049347792898 0.20691254801121 -0.152061905713888 0.0271875624306495 mirMAP -0.136809577532992 3.34445240765013e-05 NA NA NA hsa-miR-30e-3p EIF4B 0.00173769765874887 0.984965501547409 -0.152061905713888 0.0271875624306495 mirMAP -0.23335200823596 4.6813466979733e-13 NA NA NA hsa-miR-335-3p EIF4B 0.34540584335595 0.00043848660222294 -0.152061905713888 0.0271875624306495 MirTarget -0.18184925891213 1.44566813952808e-15 NA NA NA hsa-miR-339-5p EIF4B 0.273253751377152 0.0185300170790638 -0.152061905713888 0.0271875624306495 miRanda -0.154794899218979 7.83659370470759e-17 NA NA NA hsa-miR-342-3p EIF4B -0.125683829770877 0.105810751640137 -0.152061905713888 0.0271875624306495 miRanda -0.150797834917468 2.18363233869528e-06 NA NA NA hsa-miR-3682-3p EIF4B 0.113471485204649 0.266481019608971 -0.152061905713888 0.0271875624306495 MirTarget -0.146814150671814 2.6059439985854e-11 NA NA NA hsa-miR-423-3p EIF4B 0.192317829125882 0.00125622290742326 -0.152061905713888 0.0271875624306495 miRNAWalker2_validate -0.157453294180685 0.000538085259664607 NA NA NA hsa-miR-484 EIF4B -0.0190828819137732 0.802298900989652 -0.152061905713888 0.0271875624306495 miRNAWalker2_validate -0.214661788802198 2.64263949840685e-12 NA NA NA hsa-miR-532-3p EIF4B 0.150624483952741 0.0599635132177191 -0.152061905713888 0.0271875624306495 miRNATAP -0.142880972254531 5.48046209246052e-07 NA NA NA hsa-miR-590-3p EIF4B 0.312951515438396 0.000480455423843996 -0.152061905713888 0.0271875624306495 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.146889392616318 1.76276693391346e-09 NA NA NA hsa-miR-9-5p EIF4E -0.125377971246422 0.269896477802284 0.000521917441616004 0.989561920017793 MirTarget -0.206255846192919 7.77430182765833e-13 NA NA NA hsa-miR-124-3p EIF4EBP1 -0.506026514549291 0.0078056370358648 0.345125060464968 2.64227717558959e-05 miRNAWalker2_validate -0.188966455099013 9.80111350430274e-28 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.0833349424517387 0.325440200253607 0.345125060464968 2.64227717558959e-05 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.46148529037995 1.70110184729277e-21 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125b-5p EIF4EBP1 -0.0119698382910496 0.890233923197358 0.345125060464968 2.64227717558959e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.308146170722745 2.72904310773947e-07 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-138-5p EIF4EBP1 -0.616087649920851 1.35200027885729e-05 0.345125060464968 2.64227717558959e-05 MirTarget;miRNATAP -0.193406903930313 4.6473196917631e-16 NA NA NA hsa-miR-146b-3p EIF4EBP1 0.283486177568242 0.0118918188864879 0.345125060464968 2.64227717558959e-05 miRNATAP -0.209872381456042 7.96296709524663e-12 NA NA NA hsa-miR-328-3p EIF4EBP1 -0.27021372890849 0.00243992234645524 0.345125060464968 2.64227717558959e-05 MirTarget -0.534447190350655 1.29869249787005e-40 NA NA NA hsa-miR-874-3p EIF4EBP1 -0.342846516198707 0.00227406462925841 0.345125060464968 2.64227717558959e-05 MirTarget -0.403175411742658 2.94827948965856e-44 NA NA NA hsa-miR-106a-5p HIF1A 0.110074064773897 0.13045815990621 -0.00484625688143137 0.948287190529417 MirTarget -0.101846451398848 0.00786647918909839 NA NA NA hsa-miR-107 HIF1A -0.121070851008387 0.198381281894242 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;miRTarBase;miRanda -0.132322237829831 7.00061612742853e-06 NA NA NA hsa-miR-138-5p HIF1A -0.616087649920851 1.35200027885729e-05 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;miRTarBase -0.165502020945438 2.83284283527236e-20 21875287 Western blot and reporter assays were used to assess HIF-1a as a direct target of miR-138; The data showed HIF-1a to be one target of miR-138; Futhermore inhibition of the expression of HIF-1a with specific siRNA or miR-138 could increase apoptosis and reduce the migration of 786-O cells; miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of ccRCC cells kidney renal cell cancer hsa-miR-139-5p HIF1A -0.647754756897633 2.15378307237163e-06 -0.00484625688143137 0.948287190529417 miRanda -0.15297457161476 2.12780776743694e-15 NA NA NA hsa-miR-18a-5p HIF1A 0.175320895022849 0.0732549187136286 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;MirTarget -0.129916223031346 1.01926663208999e-06 25069832 Last clinically relevant correlations between miR-18a HIF1A hypoxia-responsive gene expression and distant metastasis-free survival DMFS were assessed using published expression array breast tumors data sets; We identified HIF1A as a direct target of miR-18a; Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors and that within this subtype miR-18a expression is inversely correlated with hypoxic gene expression; The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors metastasis;poor survival breast cancer hsa-miR-20a-5p HIF1A -0.0115865752288853 0.887069448776018 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;miRTarBase;MirTarget -0.112673000912119 0.00365252545629883 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-330-3p HIF1A -0.427388106938151 0.00300489284414266 -0.00484625688143137 0.948287190529417 MirTarget;PITA -0.116720940808285 6.02712620528516e-11 NA NA NA hsa-miR-338-3p HIF1A -0.39963704679384 0.0034410643220691 -0.00484625688143137 0.948287190529417 MirTarget;PITA;miRanda -0.168505832987204 2.19429877940535e-16 NA NA NA hsa-miR-338-5p HIF1A -0.424003687569629 0.00246415720301323 -0.00484625688143137 0.948287190529417 MirTarget;PITA;miRNATAP -0.11983832401039 1.29865674406497e-10 NA NA NA hsa-miR-33a-5p HIF1A 0.0197996465877179 0.86830656038963 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate -0.102950741341759 2.74195519214452e-06 NA NA NA hsa-miR-346 HIF1A -0.577786425963268 2.10883270131593e-09 -0.00484625688143137 0.948287190529417 miRanda -0.147315192018374 3.61376868607022e-08 NA NA NA hsa-miR-361-5p HIF1A 0.0107519600643302 0.882230614095565 -0.00484625688143137 0.948287190529417 miRanda -0.258505450799868 6.22305933429022e-09 NA NA NA hsa-miR-433-3p HIF1A -0.584416505057956 0.00091765848343232 -0.00484625688143137 0.948287190529417 MirTarget -0.112298468414992 7.58027288480129e-15 NA NA NA hsa-miR-543 HIF1A -0.347737549779625 0.0157394585079683 -0.00484625688143137 0.948287190529417 miRanda -0.106805373479425 6.61274439561097e-09 NA NA NA hsa-miR-582-3p HIF1A -0.11807589183011 0.304077332003677 -0.00484625688143137 0.948287190529417 PITA -0.15709347676521 8.94306398856027e-12 NA NA NA hsa-miR-582-5p HIF1A -0.215764335500665 0.0760892640434509 -0.00484625688143137 0.948287190529417 MirTarget;PITA;miRNATAP -0.149685053695624 1.07373090822328e-12 NA NA NA hsa-miR-889-3p HIF1A -0.380772047661407 0.0172235256323877 -0.00484625688143137 0.948287190529417 MirTarget -0.104858814783013 9.61920147963016e-11 NA NA NA hsa-miR-935 HIF1A -0.277848050075718 0.02166231531395 -0.00484625688143137 0.948287190529417 MirTarget;PITA -0.15182237312319 2.87889204454712e-12 NA NA NA hsa-miR-320a IGF1 0.092135599636725 0.243028758989929 -0.203195580339987 0.029670632911231 miRNATAP -0.272065311188534 2.24035754570114e-05 NA NA NA hsa-miR-592 IGF1 0.0170005651576508 0.876633091134809 -0.203195580339987 0.029670632911231 mirMAP -0.113833175952146 0.00219422982453576 NA NA NA hsa-miR-9-3p IGF1 -0.184945845984695 0.0290051908009009 -0.203195580339987 0.029670632911231 MirTarget -0.387265166384702 1.83580721842057e-09 NA NA NA hsa-let-7a-3p MAPK1 0.0530563276543763 0.370749834463566 -0.213353498035088 0.000389157534366882 mirMAP -0.101943093753909 0.00192343923976389 NA NA NA hsa-miR-15b-5p MAPK1 0.592863156692837 1.41971517354055e-10 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate -0.146191950491781 3.61739654178022e-14 NA NA NA hsa-miR-17-5p MAPK1 0.0975751369167082 0.20621110214601 -0.213353498035088 0.000389157534366882 TargetScan -0.110084866776271 7.91694183424384e-05 NA NA NA hsa-miR-19a-3p MAPK1 0.0466707843731911 0.576818938277755 -0.213353498035088 0.000389157534366882 mirMAP -0.128018489349713 2.73892272625697e-09 NA NA NA hsa-miR-19b-3p MAPK1 -0.0138427450847924 0.856506310673067 -0.213353498035088 0.000389157534366882 mirMAP -0.176138435921289 5.03823623056019e-12 NA NA NA hsa-miR-320a MAPK1 0.092135599636725 0.243028758989929 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.152520075612356 2.3025642938828e-08 NA NA NA hsa-miR-454-3p MAPK1 0.177318549827649 0.0120865170334418 -0.213353498035088 0.000389157534366882 mirMAP -0.118488517070993 3.52065356643667e-06 NA NA NA hsa-miR-500a-3p MAPK1 0.0479457078972052 0.49420307623914 -0.213353498035088 0.000389157534366882 mirMAP -0.108343486711378 0.000199332911985672 NA NA NA hsa-miR-320b MAPK3 0.283477746304177 0.0005953763020907 -0.216288134544279 3.58169845564714e-05 miRNAWalker2_validate -0.103417988183093 3.03681040754152e-07 NA NA NA hsa-miR-542-3p MAPK3 0.0835995677900829 0.403838744494071 -0.216288134544279 3.58169845564714e-05 miRanda -0.133723416342879 2.41125253328141e-13 NA NA NA hsa-miR-320a PDPK1 0.092135599636725 0.243028758989929 -0.124922548123071 0.0272075929298163 miRanda -0.122231777017362 8.84868459069661e-05 NA NA NA hsa-miR-374a-3p PDPK1 0.176226170437625 0.0343958848425446 -0.124922548123071 0.0272075929298163 mirMAP -0.151634704051745 2.27533108343501e-07 NA NA NA hsa-miR-423-5p PDPK1 0.0965587900813789 0.148039180704338 -0.124922548123071 0.0272075929298163 miRNAWalker2_validate -0.124647638553822 0.000175919526142779 NA NA NA hsa-miR-93-5p PDPK1 0.139766237971122 0.101057320076629 -0.124922548123071 0.0272075929298163 mirMAP -0.199867731891363 1.51820751789459e-08 NA NA NA hsa-miR-124-3p PGF -0.506026514549291 0.0078056370358648 -0.341184446598072 0.02198133567065 MirTarget;miRNATAP -0.12378981779743 0.000279266195514154 NA NA NA hsa-miR-142-3p PGF 0.558908907203977 1.37828834702416e-05 -0.341184446598072 0.02198133567065 miRanda -0.209524698619111 4.8489187207237e-05 NA NA NA hsa-miR-146b-5p PGF 0.441078059667297 0.000237619929889385 -0.341184446598072 0.02198133567065 miRanda -0.219423284623696 9.73569588345958e-05 NA NA NA hsa-miR-149-5p PGF -0.0535821592029952 0.657713892012548 -0.341184446598072 0.02198133567065 miRNATAP -0.335460001684344 4.97608776107746e-10 NA NA NA hsa-miR-184 PGF -0.842534984406592 6.08844932016991e-08 -0.341184446598072 0.02198133567065 miRanda -0.136337291100717 0.000950149149887701 NA NA NA hsa-miR-199b-5p PGF 0.436298593972862 0.00200225454383871 -0.341184446598072 0.02198133567065 miRanda -0.150774194706357 0.000927470972217645 NA NA NA hsa-miR-335-5p PGF 0.0938511632756978 0.336889056387694 -0.341184446598072 0.02198133567065 miRNATAP -0.314497501310152 2.85681687322176e-06 NA NA NA hsa-miR-34a-5p PGF 0.143472919835524 0.211283228567057 -0.341184446598072 0.02198133567065 miRNATAP -0.279835357608525 1.1066200175762e-06 NA NA NA hsa-miR-766-3p PGF -0.147747825439875 0.266658981351507 -0.341184446598072 0.02198133567065 MirTarget -0.244529156614663 3.20505159007913e-07 NA NA NA hsa-miR-146b-5p PIK3CA 0.441078059667297 0.000237619929889385 0.037489443318349 0.579330715365297 mirMAP -0.131612247931155 2.37773318343185e-08 NA NA NA hsa-miR-339-5p PIK3CA 0.273253751377152 0.0185300170790638 0.037489443318349 0.579330715365297 miRanda -0.104034425659594 8.90794530378182e-06 NA NA NA hsa-miR-361-5p PIK3CA 0.0107519600643302 0.882230614095565 0.037489443318349 0.579330715365297 mirMAP -0.180837597518142 0.000106487510577531 NA NA NA hsa-miR-501-5p PIK3CA 0.0878951859817452 0.309663377222443 0.037489443318349 0.579330715365297 mirMAP -0.121849868853655 0.000118457183740553 NA NA NA hsa-miR-130b-3p PIK3CB 0.503911467685709 9.46590588950823e-08 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.103286697323809 1.47078743054601e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.0466707843731911 0.576818938277755 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.106776286308973 5.5364329421429e-07 NA NA NA hsa-miR-19b-3p PIK3CB -0.0138427450847924 0.856506310673067 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.144620281397534 1.13083007810642e-08 NA NA NA hsa-miR-25-3p PIK3CB 0.316649850160985 0.000777982468387578 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.107740273525281 5.28619562870356e-06 NA NA NA hsa-miR-126-3p PIK3CG 0.283844173647452 0.0045313860754322 0.426342297358177 0.000910429107358105 miRTarBase -0.253640716789511 9.06991114742445e-05 NA NA NA hsa-miR-137 PIK3CG -0.924849266740909 1.546832202049e-06 0.426342297358177 0.000910429107358105 miRanda -0.150716294097788 1.51412490486832e-07 NA NA NA hsa-miR-139-5p PIK3CG -0.647754756897633 2.15378307237163e-06 0.426342297358177 0.000910429107358105 miRanda -0.231442980598987 3.92120693342636e-08 NA NA NA hsa-miR-103a-3p PIK3R1 -0.147443193527362 0.128400914654149 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.281302889120328 4.63842851180526e-09 NA NA NA hsa-miR-106a-5p PIK3R1 0.110074064773897 0.13045815990621 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.141577511066847 0.000568718663709082 NA NA NA hsa-miR-106b-5p PIK3R1 0.167096183547615 0.0497544396383451 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.114620357579885 0.00229922204074265 NA NA NA hsa-miR-1301-3p PIK3R1 -0.105695714210758 0.152249184194132 -0.259275224308753 0.00106935451973482 MirTarget -0.230097168026832 5.13675721710063e-09 NA NA NA hsa-miR-150-5p PIK3R1 0.0645271721519611 0.513295658828718 -0.259275224308753 0.00106935451973482 MirTarget -0.105207403299517 0.000393418533820088 NA NA NA hsa-miR-15a-5p PIK3R1 0.142658985373611 0.0536219185009004 -0.259275224308753 0.00106935451973482 MirTarget -0.230258286136212 5.21596791619245e-07 NA NA NA hsa-miR-15b-5p PIK3R1 0.592863156692837 1.41971517354055e-10 -0.259275224308753 0.00106935451973482 MirTarget -0.235643490684548 5.7801231863435e-14 NA NA NA hsa-miR-16-2-3p PIK3R1 0.468816222075619 7.04377763166292e-05 -0.259275224308753 0.00106935451973482 MirTarget -0.139286207343494 2.58317956279833e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.246024668671282 0.00346042804503716 -0.259275224308753 0.00106935451973482 MirTarget -0.121551450392141 0.00217223263389569 NA NA NA hsa-miR-185-5p PIK3R1 -0.0767432095218297 0.404113540276816 -0.259275224308753 0.00106935451973482 miRNATAP -0.168972197052794 1.52142067802957e-07 NA NA NA hsa-miR-186-5p PIK3R1 0.0606381894130505 0.514217717592464 -0.259275224308753 0.00106935451973482 mirMAP -0.273384834286173 4.58184035796298e-17 NA NA NA hsa-miR-199a-3p PIK3R1 0.41226331871076 0.000497136154474528 -0.259275224308753 0.00106935451973482 miRNATAP -0.150441413618647 2.58272678316472e-10 NA NA NA hsa-miR-199a-5p PIK3R1 0.174889610847968 0.0900027418912454 -0.259275224308753 0.00106935451973482 miRanda -0.169409376623758 6.00323276983558e-10 NA NA NA hsa-miR-199b-3p PIK3R1 0.411848361704393 0.000517815011892379 -0.259275224308753 0.00106935451973482 miRNATAP -0.149610269102807 2.9670988718931e-10 NA NA NA hsa-miR-199b-5p PIK3R1 0.436298593972862 0.00200225454383871 -0.259275224308753 0.00106935451973482 miRanda -0.158988773915679 1.96615064731078e-16 NA NA NA hsa-miR-200b-3p PIK3R1 0.245768526504511 0.0580744465744737 -0.259275224308753 0.00106935451973482 mirMAP -0.203398688722103 1.6080278648636e-21 NA NA NA hsa-miR-200c-3p PIK3R1 0.413752622631695 8.6936333715621e-06 -0.259275224308753 0.00106935451973482 mirMAP -0.313372851003899 1.11853298374691e-27 NA NA NA hsa-miR-21-5p PIK3R1 1.0504925175311 2.58081295984106e-11 -0.259275224308753 0.00106935451973482 miRNAWalker2_validate;MirTarget;miRNATAP -0.192193122796698 2.35557430088274e-23 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.0437233965539527 0.639996108995995 -0.259275224308753 0.00106935451973482 mirMAP -0.26421716056902 5.35024336821731e-19 NA NA NA hsa-miR-221-3p PIK3R1 -0.0109507285071775 0.936440693394519 -0.259275224308753 0.00106935451973482 MirTarget -0.125242954911868 1.02528886125279e-09 NA NA NA hsa-miR-222-3p PIK3R1 0.107117065575197 0.423818119725697 -0.259275224308753 0.00106935451973482 MirTarget -0.132930686168698 1.29543187744781e-10 NA NA NA hsa-miR-28-5p PIK3R1 0.104003572105781 0.153594705579534 -0.259275224308753 0.00106935451973482 miRanda -0.263804174247158 1.47407900801522e-10 NA NA NA hsa-miR-29b-3p PIK3R1 -0.178522712044497 0.0856106432165465 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.145678229090259 1.47483484512088e-06 NA NA NA hsa-miR-320a PIK3R1 0.092135599636725 0.243028758989929 -0.259275224308753 0.00106935451973482 miRNATAP -0.135112165926423 0.00256497204146449 NA NA NA hsa-miR-320c PIK3R1 0.343259124189966 0.000248338401291051 -0.259275224308753 0.00106935451973482 miRNATAP -0.100797336995439 0.0011155444118643 NA NA NA hsa-miR-361-5p PIK3R1 0.0107519600643302 0.882230614095565 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.28102979614435 4.07903189307061e-09 NA NA NA hsa-miR-374a-3p PIK3R1 0.176226170437625 0.0343958848425446 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.321250741910251 7.52372972851822e-15 NA NA NA hsa-miR-424-5p PIK3R1 0.25140374049676 0.00709934939774983 -0.259275224308753 0.00106935451973482 MirTarget -0.179589895147171 9.52256678975884e-09 NA NA NA hsa-miR-455-3p PIK3R1 0.512701816402104 0.000459755983280155 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRNATAP -0.161697245880861 9.23450362337655e-18 NA NA NA hsa-miR-532-3p PIK3R1 0.150624483952741 0.0599635132177191 -0.259275224308753 0.00106935451973482 MirTarget -0.152797062588971 2.75979429090484e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.0835995677900829 0.403838744494071 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda -0.126538995109648 4.83333922747737e-05 NA NA NA hsa-miR-548b-3p PIK3R1 0.340474544210108 0.00224491592019745 -0.259275224308753 0.00106935451973482 mirMAP -0.215757322792441 3.83990685247808e-18 NA NA NA hsa-miR-589-3p PIK3R1 0.00739371736361305 0.927768051649329 -0.259275224308753 0.00106935451973482 mirMAP -0.128475712773886 0.000234342022369328 NA NA NA hsa-miR-590-3p PIK3R1 0.312951515438396 0.000480455423843996 -0.259275224308753 0.00106935451973482 miRanda;mirMAP -0.281948259643294 1.55243456524174e-20 NA NA NA hsa-miR-590-5p PIK3R1 0.16946027035949 0.0386004382081678 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;miRNATAP -0.237039982006307 4.44595475697952e-12 NA NA NA hsa-miR-93-5p PIK3R1 0.139766237971122 0.101057320076629 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.261542441732551 2.52352152477154e-07 NA NA NA hsa-miR-125a-3p PIK3R2 0.183834985432376 0.106230647107917 0.0588428389717066 0.330993461191286 miRanda -0.129596879826368 7.29774749644301e-14 NA NA NA hsa-miR-135a-5p PIK3R2 -0.122734612943241 0.196985964641886 0.0588428389717066 0.330993461191286 MirTarget;miRNATAP -0.131986778854444 6.81341317924018e-10 NA NA NA hsa-miR-28-5p PIK3R2 0.104003572105781 0.153594705579534 0.0588428389717066 0.330993461191286 miRanda -0.220439409614541 1.97006000122873e-14 NA NA NA hsa-miR-30a-5p PIK3R2 -0.062942936611238 0.513851954700252 0.0588428389717066 0.330993461191286 miRNATAP -0.422270293356803 9.55851299393926e-41 NA NA NA hsa-miR-30b-5p PIK3R2 -0.0858101016322106 0.263243418521854 0.0588428389717066 0.330993461191286 miRNATAP -0.124149959343624 7.09161751121272e-05 NA NA NA hsa-miR-30c-5p PIK3R2 -0.0469114469943097 0.565934557464627 0.0588428389717066 0.330993461191286 miRNAWalker2_validate;miRNATAP -0.240340425585456 4.99963373312426e-15 NA NA NA hsa-miR-30d-5p PIK3R2 -0.0607010868720046 0.471410043548794 0.0588428389717066 0.330993461191286 miRNATAP -0.157898559984916 9.76384983421278e-06 NA NA NA hsa-miR-30e-5p PIK3R2 0.0764521828640934 0.41904991629622 0.0588428389717066 0.330993461191286 miRNATAP -0.28288573453624 2.98060149038092e-23 NA NA NA hsa-miR-331-3p PIK3R2 0.0126984726684189 0.905175053956974 0.0588428389717066 0.330993461191286 MirTarget -0.109375813751675 5.11486213404741e-09 NA NA NA hsa-miR-339-5p PIK3R2 0.273253751377152 0.0185300170790638 0.0588428389717066 0.330993461191286 miRanda -0.141580109769359 1.93632849649246e-17 NA NA NA hsa-miR-34a-5p PIK3R2 0.143472919835524 0.211283228567057 0.0588428389717066 0.330993461191286 MirTarget -0.127777793508925 2.24958566486742e-13 NA NA NA hsa-miR-9-3p PIK3R3 -0.184945845984695 0.0290051908009009 0.266207970572364 5.77735138484935e-05 mirMAP -0.147414732691119 0.000303043365501486 NA NA NA hsa-miR-9-5p PIK3R3 -0.125377971246422 0.269896477802284 0.266207970572364 5.77735138484935e-05 miRNATAP -0.234645741849474 2.452186835562e-05 NA NA NA hsa-miR-146a-5p PRKAA2 0.148942451196282 0.114229072828724 -0.153760632830788 0.0160802531184971 MirTarget -0.136216138680821 1.5698093569435e-06 NA NA NA hsa-miR-195-3p PRKAA2 0.100105455903079 0.133362389112338 -0.153760632830788 0.0160802531184971 mirMAP -0.111515203087672 0.00669731329074443 NA NA NA hsa-miR-92a-3p RHEB 0.0407239381334659 0.643983393805961 -0.0055020873063043 0.913980293216823 miRNAWalker2_validate -0.163147163919047 1.47617791483702e-08 NA NA NA hsa-let-7d-5p RICTOR 0.111345229817909 0.0872634398336815 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.366185012216506 5.69848512950854e-13 NA NA NA hsa-let-7e-5p RICTOR 0.0471189209570344 0.657255455444655 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.219844631645267 9.34431457732824e-14 NA NA NA hsa-let-7f-1-3p RICTOR 0.110713086694053 0.21484524300518 -0.340817529238947 9.72373497856702e-07 MirTarget -0.18551704770112 6.29069484832912e-10 NA NA NA hsa-let-7f-5p RICTOR 0.0508269185845673 0.62677515045793 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.128396059260989 0.000181315224300277 NA NA NA hsa-let-7g-5p RICTOR -0.0253396334608382 0.742556489443668 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.168335879823563 0.000259122914146362 NA NA NA hsa-let-7i-5p RICTOR 0.0952853587923244 0.192120688957249 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.236335804494887 5.14669081578208e-07 NA NA NA hsa-miR-1301-3p RICTOR -0.105695714210758 0.152249184194132 -0.340817529238947 9.72373497856702e-07 MirTarget -0.230426812841658 1.15566895307326e-09 NA NA NA hsa-miR-141-3p RICTOR 0.41120561991992 0.000393344390969055 -0.340817529238947 9.72373497856702e-07 MirTarget -0.171392968001866 1.95588251346862e-13 NA NA NA hsa-miR-142-3p RICTOR 0.558908907203977 1.37828834702416e-05 -0.340817529238947 9.72373497856702e-07 MirTarget;PITA;miRanda;miRNATAP -0.184109249383188 2.19602910499462e-18 NA NA NA hsa-miR-142-5p RICTOR 0.434884875454107 0.000575570345702788 -0.340817529238947 9.72373497856702e-07 PITA;mirMAP -0.190450284071925 2.58036051523203e-20 NA NA NA hsa-miR-148a-3p RICTOR 0.306821592493439 0.0392356958885949 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.225144093233634 5.13508442140085e-36 NA NA NA hsa-miR-148b-3p RICTOR 0.0710353380371513 0.322794068460232 -0.340817529238947 9.72373497856702e-07 MirTarget -0.296261168065746 4.98470682637344e-12 NA NA NA hsa-miR-155-5p RICTOR 0.969837380981085 5.86551495710056e-15 -0.340817529238947 9.72373497856702e-07 miRNAWalker2_validate;miRNATAP -0.291238178583799 1.32438389659014e-51 NA NA NA hsa-miR-15a-5p RICTOR 0.142658985373611 0.0536219185009004 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.298045123440301 9.39387440736874e-12 NA NA NA hsa-miR-15b-3p RICTOR 0.690804403863844 8.48784755123775e-09 -0.340817529238947 9.72373497856702e-07 mirMAP -0.217466201885051 1.58849324219008e-24 NA NA NA hsa-miR-15b-5p RICTOR 0.592863156692837 1.41971517354055e-10 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.337396339070396 4.97239627439238e-31 NA NA NA hsa-miR-16-1-3p RICTOR 0.346674816118499 1.86447850167636e-05 -0.340817529238947 9.72373497856702e-07 MirTarget -0.18608896869609 2.50675945169486e-08 NA NA NA hsa-miR-16-5p RICTOR 0.246024668671282 0.00346042804503716 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.221070179523461 4.60948390047702e-09 NA NA NA hsa-miR-185-5p RICTOR -0.0767432095218297 0.404113540276816 -0.340817529238947 9.72373497856702e-07 MirTarget -0.170704638663266 3.44966160760204e-08 NA NA NA hsa-miR-186-5p RICTOR 0.0606381894130505 0.514217717592464 -0.340817529238947 9.72373497856702e-07 mirMAP -0.166057942291897 2.09413091268972e-07 NA NA NA hsa-miR-18a-5p RICTOR 0.175320895022849 0.0732549187136286 -0.340817529238947 9.72373497856702e-07 miRNAWalker2_validate -0.13919802152168 4.04129549096482e-07 NA NA NA hsa-miR-204-5p RICTOR -0.288588537398065 0.113371226435822 -0.340817529238947 9.72373497856702e-07 MirTarget -0.145826898817978 2.11241791153632e-24 NA NA NA hsa-miR-27a-3p RICTOR 0.303760032895792 0.00457375391189806 -0.340817529238947 9.72373497856702e-07 miRNATAP -0.21959127497515 1.91381984711079e-16 NA NA NA hsa-miR-27b-3p RICTOR -0.0599187745243146 0.58208143475992 -0.340817529238947 9.72373497856702e-07 miRNATAP -0.177158253165587 7.12809938693104e-11 NA NA NA hsa-miR-30a-3p RICTOR 0.0655410309550977 0.509541256241954 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.308551330177004 3.90261073731891e-19 NA NA NA hsa-miR-30d-3p RICTOR 0.0854049347792898 0.20691254801121 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.235159544146309 4.45676376769869e-09 NA NA NA hsa-miR-30e-3p RICTOR 0.00173769765874887 0.984965501547409 -0.340817529238947 9.72373497856702e-07 MirTarget -0.232388809445674 5.61390782290066e-09 NA NA NA hsa-miR-324-3p RICTOR -0.0103367134443655 0.904494071318044 -0.340817529238947 9.72373497856702e-07 MirTarget;PITA -0.1294765445569 7.61328463367635e-05 NA NA NA hsa-miR-331-5p RICTOR 0.00538076980695534 0.942833685963252 -0.340817529238947 9.72373497856702e-07 PITA -0.213999650151533 2.71520590109557e-09 NA NA NA hsa-miR-335-5p RICTOR 0.0938511632756978 0.336889056387694 -0.340817529238947 9.72373497856702e-07 miRNAWalker2_validate -0.11553010021071 4.39787377600229e-05 NA NA NA hsa-miR-342-3p RICTOR -0.125683829770877 0.105810751640137 -0.340817529238947 9.72373497856702e-07 MirTarget;PITA;miRanda;miRNATAP -0.137942536903342 0.000435023034377486 NA NA NA hsa-miR-365a-3p RICTOR -0.184222766207919 0.0292663235724171 -0.340817529238947 9.72373497856702e-07 MirTarget -0.23825980761403 1.64609178740656e-13 NA NA NA hsa-miR-424-5p RICTOR 0.25140374049676 0.00709934939774983 -0.340817529238947 9.72373497856702e-07 MirTarget;miRNATAP -0.117291798451838 0.00011319803960031 NA NA NA hsa-miR-452-5p RICTOR 0.599327068454211 1.02031931068531e-05 -0.340817529238947 9.72373497856702e-07 mirMAP -0.145719448866168 5.39481311969316e-14 NA NA NA hsa-miR-455-3p RICTOR 0.512701816402104 0.000459755983280155 -0.340817529238947 9.72373497856702e-07 MirTarget;PITA;miRNATAP -0.156921582712592 4.80985313217028e-18 NA NA NA hsa-miR-500a-5p RICTOR 0.0634452729978863 0.396072382601677 -0.340817529238947 9.72373497856702e-07 MirTarget;mirMAP -0.267950227114605 6.95606635539543e-14 NA NA NA hsa-miR-501-5p RICTOR 0.0878951859817452 0.309663377222443 -0.340817529238947 9.72373497856702e-07 PITA -0.221938409661523 7.54513025040338e-13 NA NA NA hsa-miR-576-5p RICTOR 0.106482276040047 0.194379152564166 -0.340817529238947 9.72373497856702e-07 PITA;mirMAP -0.17634170781602 1.19078498816092e-07 NA NA NA hsa-miR-590-3p RICTOR 0.312951515438396 0.000480455423843996 -0.340817529238947 9.72373497856702e-07 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.210172011491685 1.52564599443315e-12 NA NA NA hsa-miR-654-3p RICTOR -0.00355488592826836 0.97967144096285 -0.340817529238947 9.72373497856702e-07 MirTarget;PITA;miRNATAP -0.104790123738468 6.86372679519284e-08 NA NA NA hsa-miR-660-5p RICTOR -0.138989893523975 0.0945491063873448 -0.340817529238947 9.72373497856702e-07 MirTarget -0.112113292712561 0.00156330481036737 NA NA NA hsa-miR-760 RICTOR -0.137843834465109 0.26672647203378 -0.340817529238947 9.72373497856702e-07 miRNATAP -0.102716018404033 2.1323779256292e-06 NA NA NA hsa-miR-98-5p RICTOR -0.0806971683871618 0.251777941211683 -0.340817529238947 9.72373497856702e-07 MirTarget -0.224688427746988 2.37944610696123e-07 NA NA NA hsa-let-7d-5p RPS6 0.111345229817909 0.0872634398336815 -0.104558379713959 0.190176886993187 miRNAWalker2_validate -0.29256917297677 8.13900552454981e-09 NA NA NA hsa-miR-15b-5p RPS6 0.592863156692837 1.41971517354055e-10 -0.104558379713959 0.190176886993187 miRNAWalker2_validate -0.165622735662723 4.45449155751687e-08 NA NA NA hsa-miR-16-5p RPS6 0.246024668671282 0.00346042804503716 -0.104558379713959 0.190176886993187 miRNAWalker2_validate -0.124575650458185 0.000970490092358014 NA NA NA hsa-miR-652-3p RPS6 -0.127169279300343 0.101103251579954 -0.104558379713959 0.190176886993187 miRNAWalker2_validate -0.142807153225984 8.67104597386709e-05 NA NA NA hsa-miR-744-5p RPS6 -0.31868579180387 0.000969037378618306 -0.104558379713959 0.190176886993187 miRNAWalker2_validate -0.167109496744133 8.46766748095566e-09 NA NA NA hsa-miR-138-5p RPS6KA1 -0.616087649920851 1.35200027885729e-05 0.288456681586978 0.00241163224126765 MirTarget;miRNATAP -0.100557924867178 0.000472980824832504 NA NA NA hsa-miR-139-5p RPS6KA1 -0.647754756897633 2.15378307237163e-06 0.288456681586978 0.00241163224126765 miRanda -0.19069984741317 2.71535166303043e-10 NA NA NA hsa-miR-130b-5p RPS6KA2 0.413070888963592 1.98866876365509e-06 -0.102818285282692 0.115646038229735 mirMAP -0.126225685400395 1.01803565890354e-05 NA NA NA hsa-miR-135a-5p RPS6KA2 -0.122734612943241 0.196985964641886 -0.102818285282692 0.115646038229735 mirMAP -0.112854841699271 1.73566937878491e-05 NA NA NA hsa-miR-17-5p RPS6KA2 0.0975751369167082 0.20621110214601 -0.102818285282692 0.115646038229735 TargetScan -0.145470968862276 0.000185392599632191 NA NA NA hsa-miR-19a-3p RPS6KA2 0.0466707843731911 0.576818938277755 -0.102818285282692 0.115646038229735 MirTarget -0.109941345317371 0.000289424672612532 NA NA NA hsa-miR-19b-3p RPS6KA2 -0.0138427450847924 0.856506310673067 -0.102818285282692 0.115646038229735 MirTarget -0.107557462706343 0.0029876111469591 NA NA NA hsa-miR-3065-5p RPS6KA2 -0.262608140481507 0.0414570974148034 -0.102818285282692 0.115646038229735 mirMAP -0.118319723599353 1.9718404443808e-10 NA NA NA hsa-miR-9-3p RPS6KA2 -0.184945845984695 0.0290051908009009 -0.102818285282692 0.115646038229735 MirTarget -0.121837913254802 0.00174743974134048 NA NA NA hsa-miR-93-3p RPS6KA2 0.0778767956494004 0.272224943247293 -0.102818285282692 0.115646038229735 MirTarget -0.16728139818124 2.55778263620957e-06 NA NA NA hsa-miR-9-3p RPS6KA3 -0.184945845984695 0.0290051908009009 0.212289618101534 0.000229066563238062 mirMAP -0.321436413771326 6.97903321582923e-20 NA NA NA hsa-miR-141-3p RPS6KA6 0.41120561991992 0.000393344390969055 -0.559322866661561 0.000339724482369036 MirTarget -0.271512659861477 5.92306630978806e-06 NA NA NA hsa-miR-15a-5p RPS6KA6 0.142658985373611 0.0536219185009004 -0.559322866661561 0.000339724482369036 MirTarget -0.556901205812393 6.3498971643411e-07 NA NA NA hsa-miR-15b-5p RPS6KA6 0.592863156692837 1.41971517354055e-10 -0.559322866661561 0.000339724482369036 MirTarget -0.551470461414379 6.00052291617387e-13 NA NA NA hsa-miR-217 RPS6KA6 0.540279882451941 0.00312206944061206 -0.559322866661561 0.000339724482369036 miRanda -0.220993695538304 2.36918823439635e-09 NA NA NA hsa-miR-26a-5p RPS6KA6 0.033823776747294 0.726610414342369 -0.559322866661561 0.000339724482369036 MirTarget -0.280985599048212 0.00112588897034342 NA NA NA hsa-miR-26b-5p RPS6KA6 -0.0984536538762768 0.231803769574623 -0.559322866661561 0.000339724482369036 miRNAWalker2_validate;MirTarget -0.311579663875516 0.00185786580921919 NA NA NA hsa-miR-335-3p RPS6KA6 0.34540584335595 0.00043848660222294 -0.559322866661561 0.000339724482369036 MirTarget -0.266298020642061 0.000233350834312626 NA NA NA hsa-miR-424-5p RPS6KA6 0.25140374049676 0.00709934939774983 -0.559322866661561 0.000339724482369036 MirTarget -0.232068332229862 0.00261816668347094 NA NA NA hsa-miR-590-3p RPS6KA6 0.312951515438396 0.000480455423843996 -0.559322866661561 0.000339724482369036 MirTarget;miRanda;mirMAP;miRNATAP -0.492427473097832 6.86073047407605e-11 NA NA NA hsa-miR-103a-3p RPS6KB1 -0.147443193527362 0.128400914654149 0.0307883693941573 0.477549325099404 miRNAWalker2_validate -0.184910276785145 6.35307901545141e-17 NA NA NA hsa-miR-30a-5p RPS6KB1 -0.062942936611238 0.513851954700252 0.0307883693941573 0.477549325099404 mirMAP;miRNATAP -0.205770844947332 4.93072538380941e-21 NA NA NA hsa-miR-30b-5p RPS6KB1 -0.0858101016322106 0.263243418521854 0.0307883693941573 0.477549325099404 mirMAP -0.123678081322919 1.77291313740392e-09 NA NA NA hsa-miR-30c-5p RPS6KB1 -0.0469114469943097 0.565934557464627 0.0307883693941573 0.477549325099404 mirMAP;miRNATAP -0.167666457775001 1.62284709251961e-16 NA NA NA hsa-miR-342-3p RPS6KB1 -0.125683829770877 0.105810751640137 0.0307883693941573 0.477549325099404 miRanda -0.104465615578186 3.37906515464407e-08 NA NA NA hsa-miR-361-5p RPS6KB1 0.0107519600643302 0.882230614095565 0.0307883693941573 0.477549325099404 miRanda -0.127227133278008 1.38227078328191e-08 NA NA NA hsa-miR-500a-5p RPS6KB1 0.0634452729978863 0.396072382601677 0.0307883693941573 0.477549325099404 MirTarget -0.125164970220538 7.44035968565634e-13 NA NA NA hsa-miR-500b-5p RPS6KB1 0.0632030165009851 0.39791248661688 0.0307883693941573 0.477549325099404 MirTarget -0.124909608536446 8.29092310388171e-13 NA NA NA hsa-miR-664a-3p RPS6KB1 0.0413918462467198 0.611334357897022 0.0307883693941573 0.477549325099404 MirTarget -0.137323042284789 2.51680554045394e-17 NA NA NA hsa-miR-98-5p RPS6KB1 -0.0806971683871618 0.251777941211683 0.0307883693941573 0.477549325099404 miRNAWalker2_validate -0.119576545684213 1.48092849970582e-08 NA NA NA hsa-miR-331-3p RPS6KB2 0.0126984726684189 0.905175053956974 0.0714790859004983 0.127724239330154 miRNATAP -0.154713525602994 9.99275127049366e-21 NA NA NA hsa-miR-330-5p STK11 -0.262932095995605 0.0465226565966658 0.0323033339043022 0.501366117615011 miRanda -0.102574389360944 2.58965697812856e-19 NA NA NA hsa-miR-142-3p TSC1 0.558908907203977 1.37828834702416e-05 -0.192441231327778 7.40107573947225e-05 miRanda -0.111374073743323 4.64908845227268e-20 NA NA NA hsa-miR-155-5p TSC1 0.969837380981085 5.86551495710056e-15 -0.192441231327778 7.40107573947225e-05 mirMAP -0.164123084015485 2.27180144621668e-48 NA NA NA hsa-miR-186-5p TSC1 0.0606381894130505 0.514217717592464 -0.192441231327778 7.40107573947225e-05 mirMAP -0.108705911736173 3.84055481394815e-09 NA NA NA hsa-miR-193a-5p TSC1 0.183172152450491 0.0749251910521214 -0.192441231327778 7.40107573947225e-05 mirMAP -0.119198790777518 1.04060760014094e-14 NA NA NA hsa-miR-200c-3p TSC1 0.413752622631695 8.6936333715621e-06 -0.192441231327778 7.40107573947225e-05 mirMAP -0.115129703586264 3.51933111264652e-12 NA NA NA hsa-miR-2355-3p TSC1 0.186207523505296 0.0525918026993012 -0.192441231327778 7.40107573947225e-05 mirMAP -0.102591805644991 1.75682794703603e-10 NA NA NA hsa-miR-23a-3p TSC1 0.334693010651106 0.00144448147063433 -0.192441231327778 7.40107573947225e-05 mirMAP -0.140801821334164 1.75892233728941e-17 NA NA NA hsa-miR-28-3p TSC1 0.139444423971018 0.0811187936164314 -0.192441231327778 7.40107573947225e-05 PITA -0.17094524054426 9.41944981479638e-12 NA NA NA hsa-miR-320c TSC1 0.343259124189966 0.000248338401291051 -0.192441231327778 7.40107573947225e-05 miRanda -0.101630640797968 2.41288752485634e-09 NA NA NA hsa-miR-339-5p TSC1 0.273253751377152 0.0185300170790638 -0.192441231327778 7.40107573947225e-05 miRanda -0.123936558418944 2.19962900066711e-21 NA NA NA hsa-miR-500a-5p TSC1 0.0634452729978863 0.396072382601677 -0.192441231327778 7.40107573947225e-05 mirMAP -0.143381569080533 5.42935555808731e-12 NA NA NA hsa-miR-501-5p TSC1 0.0878951859817452 0.309663377222443 -0.192441231327778 7.40107573947225e-05 mirMAP -0.123769893215903 5.45408040105992e-12 NA NA NA hsa-miR-576-5p TSC1 0.106482276040047 0.194379152564166 -0.192441231327778 7.40107573947225e-05 mirMAP -0.118422194307578 6.7824345548354e-10 NA NA NA hsa-miR-590-3p TSC1 0.312951515438396 0.000480455423843996 -0.192441231327778 7.40107573947225e-05 miRanda -0.109468926098831 2.4056830951107e-10 NA NA NA hsa-miR-320c ULK1 0.343259124189966 0.000248338401291051 -0.0743630449148283 0.149718526783703 miRNATAP -0.100526248177877 1.5289530257126e-07 NA NA NA hsa-miR-92b-3p ULK1 -0.213968504161963 0.0523921855715716 -0.0743630449148283 0.149718526783703 miRNATAP -0.123770624143337 1.32154070395505e-11 NA NA NA hsa-miR-101-3p VEGFA -0.132333931567244 0.241891922291381 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.179012476724308 0.000221850261733319 NA NA NA hsa-miR-1224-5p VEGFA -0.53941068839383 0.00201058335769201 0.545202702414815 3.65580722751043e-08 MirTarget -0.12693052777853 1.1909229874546e-07 NA NA NA hsa-miR-129-5p VEGFA -0.567133990117126 0.00116152215679936 0.545202702414815 3.65580722751043e-08 miRanda -0.178350435603243 1.58281485759764e-13 NA NA NA hsa-miR-26b-3p VEGFA -0.0542537787460029 0.4802214385739 0.545202702414815 3.65580722751043e-08 MirTarget -0.151139595719221 0.00815352929658283 NA NA NA hsa-miR-29a-3p VEGFA -0.224140851576083 0.0349516103550236 0.545202702414815 3.65580722751043e-08 MirTarget -0.188400523607611 0.000280773283001581 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.26834261955727 0.00453760540520233 0.545202702414815 3.65580722751043e-08 MirTarget -0.238273224497899 1.35712590368669e-07 NA NA NA hsa-miR-29b-3p VEGFA -0.178522712044497 0.0856106432165465 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.174785884873336 0.000121514677714241 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.372180390387259 0.00202634431973208 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;MirTarget -0.163350888739243 2.07703033697715e-05 NA NA NA hsa-miR-330-3p VEGFA -0.427388106938151 0.00300489284414266 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.14940180557451 2.38610841931945e-07 NA NA NA hsa-miR-342-3p VEGFA -0.125683829770877 0.105810751640137 0.545202702414815 3.65580722751043e-08 miRanda;miRNATAP -0.183375082823802 0.00268020639799555 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA -0.210113949579608 0.0056866083818614 0.545202702414815 3.65580722751043e-08 MirTarget -0.259691752964477 3.6506936798186e-05 NA NA NA hsa-miR-383-5p VEGFA -0.850440167826561 1.6745326125383e-07 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.171548247272876 2.39831482676198e-11 NA NA NA hsa-miR-497-5p VEGFA -0.000783764887886562 0.991703566618871 0.545202702414815 3.65580722751043e-08 MirTarget -0.217975385158274 0.000295143152499975 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-504-5p VEGFA -0.510726779625117 6.12122269907368e-05 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase -0.212758235683993 1.16548576784258e-10 NA NA NA hsa-miR-9-5p VEGFA -0.125377971246422 0.269896477802284 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.372852027573008 5.51606960459938e-05 NA NA NA hsa-miR-140-5p VEGFB 0.065063507103468 0.380452509211773 -0.0480203658065861 0.445525895152113 miRanda -0.100656379111656 0.00277375404658955 NA NA NA